ZNF410

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.61332570
2ribosome assembly (GO:0042255)4.33465818
3cullin deneddylation (GO:0010388)4.18187899
4protein deneddylation (GO:0000338)4.13848341
5negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.93033644
6DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.92795522
7positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.87786601
8intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.83255877
9signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.83255877
10signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.83034257
11signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.83034257
12signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.83034257
13regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.73839824
14regulation of cellular amino acid metabolic process (GO:0006521)3.72185402
15DNA double-strand break processing (GO:0000729)3.71959823
16signal transduction involved in DNA integrity checkpoint (GO:0072401)3.63945588
17signal transduction involved in DNA damage checkpoint (GO:0072422)3.63945588
18signal transduction involved in cell cycle checkpoint (GO:0072395)3.60875702
19negative regulation of ligase activity (GO:0051352)3.56441750
20negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.56441750
21anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.49874900
22protein K6-linked ubiquitination (GO:0085020)3.45813043
23positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.35424423
24positive regulation of ligase activity (GO:0051351)3.31133052
25histone H2A acetylation (GO:0043968)3.11767298
26DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.03961769
27lactate metabolic process (GO:0006089)3.00878122
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.96683805
29piRNA metabolic process (GO:0034587)2.94300486
30response to pheromone (GO:0019236)2.92606498
31DNA catabolic process, exonucleolytic (GO:0000738)2.87419041
32negative regulation of protein ubiquitination (GO:0031397)2.86921716
33non-recombinational repair (GO:0000726)2.86701592
34double-strand break repair via nonhomologous end joining (GO:0006303)2.86701592
35preassembly of GPI anchor in ER membrane (GO:0016254)2.85643986
36rRNA modification (GO:0000154)2.84327748
37regulation of ubiquitin-protein transferase activity (GO:0051438)2.83510520
38regulation of ligase activity (GO:0051340)2.82286732
39antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.82122544
40branched-chain amino acid catabolic process (GO:0009083)2.81896078
41rRNA methylation (GO:0031167)2.81239501
42positive regulation of cell cycle arrest (GO:0071158)2.79021083
43regulation of retinoic acid receptor signaling pathway (GO:0048385)2.78102987
44regulation of translation in response to stress (GO:0043555)2.77247042
45DNA damage response, detection of DNA damage (GO:0042769)2.76907934
46platelet dense granule organization (GO:0060155)2.75300818
47synapsis (GO:0007129)2.74657193
48C-terminal protein lipidation (GO:0006501)2.72802910
49negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.70686653
50peptidyl-histidine modification (GO:0018202)2.68170426
51adenosine metabolic process (GO:0046085)2.63561742
52DNA deamination (GO:0045006)2.61658758
53protein K11-linked ubiquitination (GO:0070979)2.61068802
54antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.59197031
55protein heterotetramerization (GO:0051290)2.58121938
56L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.57347355
57negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.56954382
58regulation of mitotic spindle checkpoint (GO:1903504)2.53621256
59regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.53621256
60negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.52864629
61negative regulation of cell cycle G1/S phase transition (GO:1902807)2.52864629
62signal transduction in response to DNA damage (GO:0042770)2.52472749
63histone mRNA catabolic process (GO:0071044)2.50462154
64GMP metabolic process (GO:0046037)2.49512985
65DNA integration (GO:0015074)2.49462702
66rRNA catabolic process (GO:0016075)2.49003939
67DNA replication-dependent nucleosome organization (GO:0034723)2.45653589
68DNA replication-dependent nucleosome assembly (GO:0006335)2.45653589
69replication fork processing (GO:0031297)2.45431797
70C-terminal protein amino acid modification (GO:0018410)2.45213383
71cell cycle G1/S phase transition (GO:0044843)2.43339314
72G1/S transition of mitotic cell cycle (GO:0000082)2.43339314
73RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.42658293
74attachment of spindle microtubules to kinetochore (GO:0008608)2.42480472
75regulation of cellular amine metabolic process (GO:0033238)2.40305786
76hepatocyte apoptotic process (GO:0097284)2.39453616
77tRNA methylation (GO:0030488)2.36599070
78negative regulation of thymocyte apoptotic process (GO:0070244)2.36310994
79signal peptide processing (GO:0006465)2.36229241
80negative regulation of neurological system process (GO:0031645)2.34886671
81regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.34431179
82positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.34431179
83somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.34129617
84isotype switching (GO:0045190)2.34129617
85somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.34129617
86purine-containing compound salvage (GO:0043101)2.33876450
87intestinal epithelial cell development (GO:0060576)2.33412201
88tRNA aminoacylation for protein translation (GO:0006418)2.32325686
89cell wall macromolecule catabolic process (GO:0016998)2.32257884
90cytochrome complex assembly (GO:0017004)2.32172780
91recombinational repair (GO:0000725)2.32041113
92COPII vesicle coating (GO:0048208)2.30629144
93positive regulation of protein ubiquitination (GO:0031398)2.30400587
94respiratory chain complex IV assembly (GO:0008535)2.29865416
95double-strand break repair via homologous recombination (GO:0000724)2.29701519
96tRNA aminoacylation (GO:0043039)2.29022470
97amino acid activation (GO:0043038)2.29022470
98ER overload response (GO:0006983)2.28905354
99regulation of cell cycle arrest (GO:0071156)2.27624157
100protein-cofactor linkage (GO:0018065)2.27470421

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.14844069
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.89219851
3* GABP_17652178_ChIP-ChIP_JURKAT_Human3.75550817
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.18243154
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.92989397
6ELK1_19687146_ChIP-ChIP_HELA_Human2.89442626
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.88369130
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.87279199
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.78533051
10VDR_23849224_ChIP-Seq_CD4+_Human2.72416568
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.68262080
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.54864758
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.47265346
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.45608365
15ZNF274_21170338_ChIP-Seq_K562_Hela2.40008936
16PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.38344776
17NOTCH1_21737748_ChIP-Seq_TLL_Human2.35085241
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.27420049
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.25376682
20PADI4_21655091_ChIP-ChIP_MCF-7_Human2.13794554
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.04079978
22FOXP3_21729870_ChIP-Seq_TREG_Human2.01385597
23FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.00209804
24SRF_21415370_ChIP-Seq_HL-1_Mouse1.93383997
25HOXB4_20404135_ChIP-ChIP_EML_Mouse1.91970658
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.91944053
27DCP1A_22483619_ChIP-Seq_HELA_Human1.88354408
28IGF1R_20145208_ChIP-Seq_DFB_Human1.80823549
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.78965634
30IRF8_22096565_ChIP-ChIP_GC-B_Human1.78241595
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.68302448
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.68125655
33BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.58890634
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58050395
35IRF8_21731497_ChIP-ChIP_J774_Mouse1.57784721
36CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.52129968
37BP1_19119308_ChIP-ChIP_Hs578T_Human1.49584549
38E2F7_22180533_ChIP-Seq_HELA_Human1.48955643
39VDR_22108803_ChIP-Seq_LS180_Human1.48527756
40* GABP_19822575_ChIP-Seq_HepG2_Human1.47378257
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.43229769
42TFEB_21752829_ChIP-Seq_HELA_Human1.39662593
43EWS_26573619_Chip-Seq_HEK293_Human1.38853422
44IRF1_19129219_ChIP-ChIP_H3396_Human1.38216376
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.34353111
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33330152
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.32857717
48GATA3_26560356_Chip-Seq_TH2_Human1.26605776
49ELK1_22589737_ChIP-Seq_MCF10A_Human1.25660249
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.25545948
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20171247
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17796458
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15950138
54CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15520992
55E2F1_18555785_ChIP-Seq_MESCs_Mouse1.12360122
56SALL4_22934838_ChIP-ChIP_CD34+_Human1.12290927
57KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.12233915
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12144637
59ER_23166858_ChIP-Seq_MCF-7_Human1.11658623
60MYC_18940864_ChIP-ChIP_HL60_Human1.10408697
61MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09225407
62EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07408474
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05813602
64PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05748944
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05219120
66KDM5A_27292631_Chip-Seq_BREAST_Human1.04170555
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04055912
68* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.02279201
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02007477
70HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00928421
71MYC_19030024_ChIP-ChIP_MESCs_Mouse1.00626529
72STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.99339819
73* SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.98994884
74SPI1_23547873_ChIP-Seq_NB4_Human0.98537015
75MYB_26560356_Chip-Seq_TH2_Human0.97972891
76MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.97653373
77ELF5_23300383_ChIP-Seq_T47D_Human0.96103004
78PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94830109
79RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.94683173
80CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94116510
81EZH2_27294783_Chip-Seq_NPCs_Mouse0.93774088
82* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92150945
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90406694
84GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.89770761
85GATA1_22025678_ChIP-Seq_K562_Human0.89310950
86P300_19829295_ChIP-Seq_ESCs_Human0.89196397
87SUZ12_27294783_Chip-Seq_NPCs_Mouse0.87952871
88PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.87754701
89CIITA_25753668_ChIP-Seq_RAJI_Human0.85718689
90NFE2_27457419_Chip-Seq_LIVER_Mouse0.85331862
91STAT4_19710469_ChIP-ChIP_TH1__Mouse0.84221753
92MYC_18358816_ChIP-ChIP_MESCs_Mouse0.83576428
93CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82740340
94SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.81972479
95FUS_26573619_Chip-Seq_HEK293_Human0.81410107
96TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81011591
97MYC_18555785_ChIP-Seq_MESCs_Mouse0.80507136
98ESR1_20079471_ChIP-ChIP_T-47D_Human0.80327594
99TP53_22573176_ChIP-Seq_HFKS_Human0.79428724
100TTF2_22483619_ChIP-Seq_HELA_Human0.79294541

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair3.66508765
2MP0003806_abnormal_nucleotide_metabolis2.87956110
3MP0003786_premature_aging2.77112676
4MP0010094_abnormal_chromosome_stability2.60337090
5MP0006054_spinal_hemorrhage2.54769030
6MP0003950_abnormal_plasma_membrane2.45017296
7MP0000465_gastrointestinal_hemorrhage2.19337944
8MP0002102_abnormal_ear_morphology2.17480242
9MP0002148_abnormal_hypersensitivity_rea2.04999170
10MP0000516_abnormal_urinary_system1.93269221
11MP0005367_renal/urinary_system_phenotyp1.93269221
12MP0003693_abnormal_embryo_hatching1.92529042
13MP0001835_abnormal_antigen_presentation1.92527313
14MP0001873_stomach_inflammation1.89552802
15MP0009697_abnormal_copulation1.87742884
16MP0003186_abnormal_redox_activity1.85427908
17MP0008007_abnormal_cellular_replicative1.84709690
18MP0002166_altered_tumor_susceptibility1.82227114
19MP0003656_abnormal_erythrocyte_physiolo1.81081004
20MP0005671_abnormal_response_to1.80297875
21MP0003724_increased_susceptibility_to1.79712152
22MP0000427_abnormal_hair_cycle1.76024641
23MP0009785_altered_susceptibility_to1.74844264
24MP0002006_tumorigenesis1.68508739
25MP0000372_irregular_coat_pigmentation1.57820769
26MP0005000_abnormal_immune_tolerance1.54074788
27MP0003763_abnormal_thymus_physiology1.49268410
28MP0003077_abnormal_cell_cycle1.48297037
29MP0009764_decreased_sensitivity_to1.48118064
30MP0003718_maternal_effect1.45650344
31MP0006072_abnormal_retinal_apoptosis1.45529613
32MP0004782_abnormal_surfactant_physiolog1.41302822
33MP0005253_abnormal_eye_physiology1.40064799
34MP0005075_abnormal_melanosome_morpholog1.37857770
35MP0010234_abnormal_vibrissa_follicle1.37726201
36MP0010678_abnormal_skin_adnexa1.37528957
37MP0001853_heart_inflammation1.36129350
38MP0008057_abnormal_DNA_replication1.35237929
39MP0004957_abnormal_blastocyst_morpholog1.30844515
40MP0005084_abnormal_gallbladder_morpholo1.29929876
41MP0001764_abnormal_homeostasis1.29538775
42MP0002254_reproductive_system_inflammat1.28203776
43MP0001800_abnormal_humoral_immune1.28199931
44MP0000358_abnormal_cell_content/1.27317645
45MP0002405_respiratory_system_inflammati1.26243748
46MP0003111_abnormal_nucleus_morphology1.26043234
47MP0000383_abnormal_hair_follicle1.24381070
48MP0005410_abnormal_fertilization1.24198182
49MP0008995_early_reproductive_senescence1.23038800
50MP0006036_abnormal_mitochondrial_physio1.21533972
51MP0002452_abnormal_antigen_presenting1.20168918
52MP0002723_abnormal_immune_serum1.18772379
53MP0006082_CNS_inflammation1.15462343
54MP0009333_abnormal_splenocyte_physiolog1.12955606
55MP0002234_abnormal_pharynx_morphology1.11127101
56MP0001845_abnormal_inflammatory_respons1.08446526
57MP0000015_abnormal_ear_pigmentation1.08082525
58MP0005387_immune_system_phenotype1.06350999
59MP0001790_abnormal_immune_system1.06350999
60MP0005248_abnormal_Harderian_gland1.06240584
61MP0005310_abnormal_salivary_gland1.05044200
62MP0002138_abnormal_hepatobiliary_system1.02078953
63MP0002420_abnormal_adaptive_immunity1.01795671
64MP0002837_dystrophic_cardiac_calcinosis1.01409943
65MP0001819_abnormal_immune_cell1.00906421
66MP0000689_abnormal_spleen_morphology1.00755761
67MP0002095_abnormal_skin_pigmentation1.00715654
68MP0000613_abnormal_salivary_gland1.00232056
69MP0001545_abnormal_hematopoietic_system0.98112282
70MP0005397_hematopoietic_system_phenotyp0.98112282
71MP0002163_abnormal_gland_morphology0.96741212
72MP0008961_abnormal_basal_metabolism0.95698703
73MP0004264_abnormal_extraembryonic_tissu0.95239918
74MP0006035_abnormal_mitochondrial_morpho0.92742746
75MP0002722_abnormal_immune_system0.91950631
76MP0001929_abnormal_gametogenesis0.91678745
77MP0000569_abnormal_digit_pigmentation0.90567764
78MP0002332_abnormal_exercise_endurance0.89870158
79MP0008932_abnormal_embryonic_tissue0.89345597
80MP0001243_abnormal_dermal_layer0.88921442
81MP0003868_abnormal_feces_composition0.88893835
82MP0001529_abnormal_vocalization0.88763954
83MP0000538_abnormal_urinary_bladder0.88346751
84MP0008789_abnormal_olfactory_epithelium0.87788826
85MP0010307_abnormal_tumor_latency0.86780276
86MP0010352_gastrointestinal_tract_polyps0.86465023
87MP0008877_abnormal_DNA_methylation0.86449379
88MP0002398_abnormal_bone_marrow0.84723651
89MP0001119_abnormal_female_reproductive0.81779173
90MP0002751_abnormal_autonomic_nervous0.81117179
91MP0002019_abnormal_tumor_incidence0.80501896
92MP0003866_abnormal_defecation0.80488269
93MP0003436_decreased_susceptibility_to0.79211466
94MP0003195_calcinosis0.79086446
95MP0004147_increased_porphyrin_level0.78624486
96MP0002160_abnormal_reproductive_system0.77007991
97MP0000627_abnormal_mammary_gland0.74435732
98MP0005025_abnormal_response_to0.73907142
99MP0003943_abnormal_hepatobiliary_system0.73515165
100MP0000716_abnormal_immune_system0.72950455

Predicted human phenotypes

RankGene SetZ-score
1Abnormal glycosylation (HP:0012345)2.99667984
2Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.99667984
3Abnormal protein N-linked glycosylation (HP:0012347)2.99667984
4Abnormal protein glycosylation (HP:0012346)2.99667984
5Dyschromatopsia (HP:0007641)2.92928027
6Aplasia/hypoplasia of the uterus (HP:0008684)2.90145607
7Hypoplasia of the uterus (HP:0000013)2.89468770
8Type I transferrin isoform profile (HP:0003642)2.87844775
9Microvesicular hepatic steatosis (HP:0001414)2.83118926
10Stomatitis (HP:0010280)2.73936129
11Thyroiditis (HP:0100646)2.70159929
12Abnormality of methionine metabolism (HP:0010901)2.69300371
13Large for gestational age (HP:0001520)2.46650559
14Pancreatic cysts (HP:0001737)2.40448242
15Tubulointerstitial nephritis (HP:0001970)2.38640776
16Renal cortical cysts (HP:0000803)2.35640882
17Autoimmune hemolytic anemia (HP:0001890)2.34656719
18Reduced antithrombin III activity (HP:0001976)2.34634568
19Abnormality of the preputium (HP:0100587)2.33774880
20Chronic diarrhea (HP:0002028)2.33325021
21Amyotrophic lateral sclerosis (HP:0007354)2.31047804
22Breast carcinoma (HP:0003002)2.30434521
23Methylmalonic aciduria (HP:0012120)2.28268049
24Bile duct proliferation (HP:0001408)2.28152514
25Abnormal biliary tract physiology (HP:0012439)2.28152514
26Abnormality of aspartate family amino acid metabolism (HP:0010899)2.27131382
27Albinism (HP:0001022)2.24141240
28True hermaphroditism (HP:0010459)2.23413004
29Hepatocellular necrosis (HP:0001404)2.22172324
30Medial flaring of the eyebrow (HP:0010747)2.21040409
31Hypoproteinemia (HP:0003075)2.19497477
32Methylmalonic acidemia (HP:0002912)2.19383641
33Carpal bone hypoplasia (HP:0001498)2.18954652
34Hepatic necrosis (HP:0002605)2.16695741
35Cutaneous melanoma (HP:0012056)2.15624567
36Pancytopenia (HP:0001876)2.13764579
37Short tibia (HP:0005736)2.13115781
38Atrophy/Degeneration involving motor neurons (HP:0007373)2.11601941
39Increased serum pyruvate (HP:0003542)2.09380259
40Increased CSF lactate (HP:0002490)2.09253337
41Abnormality of chromosome stability (HP:0003220)2.07605088
42Abnormality of the ileum (HP:0001549)2.07464130
43Aplastic anemia (HP:0001915)2.06280515
44Abnormality of the renal cortex (HP:0011035)2.06255535
45Sloping forehead (HP:0000340)2.05454953
46Chromosomal breakage induced by crosslinking agents (HP:0003221)2.04984802
47Meckel diverticulum (HP:0002245)2.04175737
48Abnormality of glycolysis (HP:0004366)2.02166793
49Severe combined immunodeficiency (HP:0004430)2.01880784
50IgG deficiency (HP:0004315)2.01347541
51Nephrogenic diabetes insipidus (HP:0009806)1.99929611
52Aplasia/Hypoplasia of the tibia (HP:0005772)1.99768833
53Retinal dysplasia (HP:0007973)1.98514093
54Aplasia/Hypoplasia of the uvula (HP:0010293)1.98096463
55Constricted visual fields (HP:0001133)1.96991755
56Molar tooth sign on MRI (HP:0002419)1.96807037
57Abnormality of midbrain morphology (HP:0002418)1.96807037
58Attenuation of retinal blood vessels (HP:0007843)1.96015773
59Congenital primary aphakia (HP:0007707)1.95957267
60Prostate neoplasm (HP:0100787)1.95147293
61Neoplasm of the adrenal gland (HP:0100631)1.94861436
62Clubbing of toes (HP:0100760)1.94581307
63Aplasia/Hypoplasia of the tongue (HP:0010295)1.92501827
64Hypokinesia (HP:0002375)1.91296861
65Abnormality of B cell number (HP:0010975)1.90601256
66Increased serum lactate (HP:0002151)1.90556135
67Chronic hepatic failure (HP:0100626)1.89118841
68Pancreatic fibrosis (HP:0100732)1.86879643
69IgM deficiency (HP:0002850)1.86796999
70Hypothermia (HP:0002045)1.85219986
71Absent rod-and cone-mediated responses on ERG (HP:0007688)1.85183459
723-Methylglutaconic aciduria (HP:0003535)1.84605297
73Abolished electroretinogram (ERG) (HP:0000550)1.84452492
74Entropion (HP:0000621)1.83826844
75Median cleft lip (HP:0000161)1.82486622
76Abnormal umbilical cord blood vessels (HP:0011403)1.82365342
77Single umbilical artery (HP:0001195)1.82365342
78Abnormality of the fetal cardiovascular system (HP:0010948)1.82365342
79Ependymoma (HP:0002888)1.81707022
80Small intestinal stenosis (HP:0012848)1.80777149
81Duodenal stenosis (HP:0100867)1.80777149
82Abnormality of eosinophils (HP:0001879)1.79792209
83B lymphocytopenia (HP:0010976)1.78984528
84Mitochondrial inheritance (HP:0001427)1.78227540
85Abnormality of the astrocytes (HP:0100707)1.75542950
86Astrocytoma (HP:0009592)1.75542950
87Autoimmune thrombocytopenia (HP:0001973)1.74862088
88Adrenal hypoplasia (HP:0000835)1.74371306
89Combined immunodeficiency (HP:0005387)1.74284714
90Type II lissencephaly (HP:0007260)1.73877083
91Eosinophilia (HP:0001880)1.73669357
92Neutropenia (HP:0001875)1.73255002
93Acute hepatic failure (HP:0006554)1.72881419
94Thyroid carcinoma (HP:0002890)1.72083773
95Posterior subcapsular cataract (HP:0007787)1.69761837
96Postnatal microcephaly (HP:0005484)1.67273979
97Lactic acidosis (HP:0003128)1.66394520
98Chromsome breakage (HP:0040012)1.65742498
99Abnormality of the metopic suture (HP:0005556)1.65567807
100Abnormality of the anterior horn cell (HP:0006802)1.65482486

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK35.22380752
2TRIM283.76927768
3MST43.31170716
4EIF2AK13.04517035
5FRK2.83568271
6BUB12.77373203
7ZAK2.50854535
8BCKDK2.38267582
9STK162.25939092
10SRPK12.15691359
11PDK22.15336188
12NUAK12.09552321
13ERBB32.04174422
14SIK32.00404817
15TXK1.99255036
16BCR1.76945998
17VRK21.68207354
18BRSK21.63017489
19TAOK31.57704572
20CCNB11.56895650
21MAP4K21.56687848
22TSSK61.53794089
23MAP3K121.52790120
24INSRR1.49489586
25NEK11.46602231
26PINK11.39834366
27PBK1.36111246
28VRK11.36072854
29PLK31.24970755
30FER1.24879872
31BMPR1B1.23822716
32BRD41.19979816
33CSNK1A1L1.17591642
34CSNK1G31.13840418
35RPS6KA41.06486340
36WEE11.05982458
37TIE11.03500145
38GRK11.02191290
39PLK40.98758260
40CSNK1G10.95884064
41TLK10.94300976
42MAP3K30.93436457
43MARK30.87811134
44CDK80.87637384
45IKBKB0.86903035
46PIM20.85118566
47SCYL20.84609810
48EIF2AK20.81645443
49ADRBK20.80107357
50RPS6KA50.78879399
51TESK20.78771935
52NEK60.77965129
53BMPR20.76890262
54FES0.76168735
55MYLK0.73431433
56TBK10.72293960
57STK100.71529246
58MUSK0.70618473
59CSNK1G20.68635989
60STK390.65248932
61WNK30.64553430
62PLK10.64061819
63IKBKE0.63745407
64FLT30.62897077
65IRAK30.56042970
66RAF10.54363147
67MAP2K70.53628828
68OXSR10.52728366
69PRKCE0.51718224
70TGFBR10.51225352
71PLK20.50322675
72TYK20.49943684
73PTK2B0.48296683
74PRKD30.47720175
75ERBB40.47200504
76GRK70.45879219
77MST1R0.44790775
78ATR0.44739180
79PAK30.44331601
80TEC0.44174124
81MAP3K50.43570216
82AURKB0.43009957
83ATM0.42164897
84PRKCQ0.39338952
85MKNK10.38793075
86PIK3CA0.34040415
87CHUK0.33452511
88KDR0.33299082
89TTK0.32222359
90STK38L0.31783814
91ABL10.31591051
92KSR10.30475489
93BRSK10.30267328
94DAPK10.29936109
95CSNK2A10.29770887
96EPHA30.29648771
97EGFR0.29636428
98NME20.27474136
99TGFBR20.27132056
100ILK0.25935518

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.15991196
2Protein export_Homo sapiens_hsa030602.93819324
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.89817044
4Non-homologous end-joining_Homo sapiens_hsa034502.77227786
5Fanconi anemia pathway_Homo sapiens_hsa034602.45723603
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.32794821
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.31272792
8Fatty acid elongation_Homo sapiens_hsa000622.15779664
9Mismatch repair_Homo sapiens_hsa034302.08936653
10Propanoate metabolism_Homo sapiens_hsa006402.06531637
11Homologous recombination_Homo sapiens_hsa034402.02429533
12RNA polymerase_Homo sapiens_hsa030202.00155758
13Sulfur metabolism_Homo sapiens_hsa009201.96833976
14Basal transcription factors_Homo sapiens_hsa030221.91787227
15DNA replication_Homo sapiens_hsa030301.79301726
16Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.78611004
17RNA transport_Homo sapiens_hsa030131.77169519
18Base excision repair_Homo sapiens_hsa034101.74213403
19Regulation of autophagy_Homo sapiens_hsa041401.73680663
20Nucleotide excision repair_Homo sapiens_hsa034201.61771192
21Selenocompound metabolism_Homo sapiens_hsa004501.58138710
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55081135
23Pyrimidine metabolism_Homo sapiens_hsa002401.48572286
24RNA degradation_Homo sapiens_hsa030181.43722532
25Legionellosis_Homo sapiens_hsa051341.42554366
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.37733903
27p53 signaling pathway_Homo sapiens_hsa041151.25966729
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.24827003
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.22120742
30Spliceosome_Homo sapiens_hsa030401.15570516
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.14966048
32Purine metabolism_Homo sapiens_hsa002301.14426934
33Rheumatoid arthritis_Homo sapiens_hsa053231.07207198
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06963717
35Primary immunodeficiency_Homo sapiens_hsa053401.04025702
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.02701965
37Measles_Homo sapiens_hsa051621.01936016
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01747261
39Collecting duct acid secretion_Homo sapiens_hsa049661.00887763
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00806815
41Herpes simplex infection_Homo sapiens_hsa051681.00677867
42Butanoate metabolism_Homo sapiens_hsa006501.00582752
43SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97326549
44Glutathione metabolism_Homo sapiens_hsa004800.93592899
45Type I diabetes mellitus_Homo sapiens_hsa049400.90657970
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88418415
47Cell cycle_Homo sapiens_hsa041100.87960950
48Peroxisome_Homo sapiens_hsa041460.87925840
49Allograft rejection_Homo sapiens_hsa053300.87741544
50Systemic lupus erythematosus_Homo sapiens_hsa053220.87477874
51Circadian rhythm_Homo sapiens_hsa047100.86289188
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85669201
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84592744
54Caffeine metabolism_Homo sapiens_hsa002320.84028828
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81956690
56Hematopoietic cell lineage_Homo sapiens_hsa046400.78790369
57Intestinal immune network for IgA production_Homo sapiens_hsa046720.77797865
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77485323
59Sphingolipid metabolism_Homo sapiens_hsa006000.76562975
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75522152
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.74330960
62N-Glycan biosynthesis_Homo sapiens_hsa005100.73061435
63Apoptosis_Homo sapiens_hsa042100.72590931
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72274722
65Epstein-Barr virus infection_Homo sapiens_hsa051690.70540056
66Autoimmune thyroid disease_Homo sapiens_hsa053200.69952911
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.69625656
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69312224
69Oxidative phosphorylation_Homo sapiens_hsa001900.68135122
70Shigellosis_Homo sapiens_hsa051310.67087356
71Vibrio cholerae infection_Homo sapiens_hsa051100.66039058
72One carbon pool by folate_Homo sapiens_hsa006700.65224106
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64959046
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.63624569
75Parkinsons disease_Homo sapiens_hsa050120.63183483
76Graft-versus-host disease_Homo sapiens_hsa053320.62981180
77Antigen processing and presentation_Homo sapiens_hsa046120.62449055
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62013573
79Steroid biosynthesis_Homo sapiens_hsa001000.61234023
80Viral carcinogenesis_Homo sapiens_hsa052030.58201500
81Hepatitis B_Homo sapiens_hsa051610.55951226
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.55031457
83Lysosome_Homo sapiens_hsa041420.53772587
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.53690741
85Tryptophan metabolism_Homo sapiens_hsa003800.53136493
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53004374
87Folate biosynthesis_Homo sapiens_hsa007900.51579281
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50797537
89TNF signaling pathway_Homo sapiens_hsa046680.49686064
90mRNA surveillance pathway_Homo sapiens_hsa030150.48971784
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47997296
92Oocyte meiosis_Homo sapiens_hsa041140.47698810
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47611990
94Metabolic pathways_Homo sapiens_hsa011000.45987970
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44722349
96Influenza A_Homo sapiens_hsa051640.44316991
97Phagosome_Homo sapiens_hsa041450.44040755
98Alcoholism_Homo sapiens_hsa050340.43805054
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43679390
100Salmonella infection_Homo sapiens_hsa051320.40871289

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