ZNF395

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endothelial cell chemotaxis (GO:0035767)4.81970586
2positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003604.53129580
3venous blood vessel morphogenesis (GO:0048845)3.83816870
4positive regulation of protein kinase C signaling (GO:0090037)3.65090373
5histone H3-K9 demethylation (GO:0033169)3.46320274
6regulation of endothelial cell chemotaxis (GO:2001026)3.42779252
7positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.39244860
8positive regulation of histone deacetylation (GO:0031065)3.38804554
9desmosome organization (GO:0002934)3.32389657
10surfactant homeostasis (GO:0043129)3.30617403
11skin morphogenesis (GO:0043589)3.25579674
12peptidyl-proline hydroxylation (GO:0019511)3.23114905
13regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.20051971
14coronary vasculature morphogenesis (GO:0060977)3.19556009
15negative regulation of bone resorption (GO:0045779)3.16596387
16negative regulation of fatty acid transport (GO:2000192)3.15343849
17vascular endothelial growth factor signaling pathway (GO:0038084)3.14312399
18regulation of extracellular matrix disassembly (GO:0010715)3.10638040
19camera-type eye morphogenesis (GO:0048593)3.08283845
20lung vasculature development (GO:0060426)3.04567028
21negative regulation of erythrocyte differentiation (GO:0045647)3.02064235
22positive regulation of fatty acid beta-oxidation (GO:0032000)2.99935374
23embryonic retina morphogenesis in camera-type eye (GO:0060059)2.99903244
24regulation of p38MAPK cascade (GO:1900744)2.98581475
25cell differentiation involved in metanephros development (GO:0072202)2.92167479
26positive regulation of p38MAPK cascade (GO:1900745)2.87188431
27cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.84649074
28regulation of fatty acid beta-oxidation (GO:0031998)2.79961841
29positive regulation of CREB transcription factor activity (GO:0032793)2.77148129
30protein hydroxylation (GO:0018126)2.75923814
31regulation of cholesterol homeostasis (GO:2000188)2.73139506
32positive regulation of protein deacetylation (GO:0090312)2.68701853
334-hydroxyproline metabolic process (GO:0019471)2.60156875
34mannose metabolic process (GO:0006013)2.59503809
35metanephric mesenchyme development (GO:0072075)2.56934883
36regulation of extracellular matrix organization (GO:1903053)2.54481032
37regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.53631287
38positive regulation of vascular permeability (GO:0043117)2.52996435
39chemical homeostasis within a tissue (GO:0048875)2.51643243
40negative regulation of bone remodeling (GO:0046851)2.49896608
41regulation of protein kinase C signaling (GO:0090036)2.49030382
42glomerular basement membrane development (GO:0032836)2.42813441
43lung epithelium development (GO:0060428)2.39960670
44planar cell polarity pathway involved in neural tube closure (GO:0090179)2.39172787
45myelin maintenance (GO:0043217)2.38409882
46regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.37340771
47mesenchymal cell differentiation involved in renal system development (GO:2001012)2.36171627
48mesenchymal cell differentiation involved in kidney development (GO:0072161)2.36171627
49insulin-like growth factor receptor signaling pathway (GO:0048009)2.35665445
50positive regulation of extracellular matrix organization (GO:1903055)2.34167694
51histone lysine demethylation (GO:0070076)2.32974713
52regulation of apoptotic process involved in morphogenesis (GO:1902337)2.31029060
53cellular response to prostaglandin stimulus (GO:0071379)2.30451722
54negative regulation of tissue remodeling (GO:0034104)2.29971546
55platelet-derived growth factor receptor signaling pathway (GO:0048008)2.29212748
56positive regulation of glycogen biosynthetic process (GO:0045725)2.28889793
57histone H3-K36 demethylation (GO:0070544)2.28470450
58eye morphogenesis (GO:0048592)2.27138425
59regulation of glucose import in response to insulin stimulus (GO:2001273)2.27004962
60positive regulation of blood vessel endothelial cell migration (GO:0043536)2.25844155
61cytoplasmic mRNA processing body assembly (GO:0033962)2.25822012
62vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.24901092
63histone demethylation (GO:0016577)2.23736151
64epithelial cell fate commitment (GO:0072148)2.19561039
65gland morphogenesis (GO:0022612)2.19150971
66ear development (GO:0043583)2.18479258
67regulation of phospholipase A2 activity (GO:0032429)2.17376538
68positive thymic T cell selection (GO:0045059)2.17216876
69negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.16922725
70regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.16136066
71metanephric tubule development (GO:0072170)2.14728982
72metanephric nephron tubule development (GO:0072234)2.14728982
73induction of positive chemotaxis (GO:0050930)2.13518483
74activation of JUN kinase activity (GO:0007257)2.13299988
75white fat cell differentiation (GO:0050872)2.12283077
76pattern specification involved in kidney development (GO:0061004)2.11373646
77kidney mesenchyme development (GO:0072074)2.10814288
78positive regulation of fatty acid oxidation (GO:0046321)2.09957402
79auditory receptor cell differentiation (GO:0042491)2.09884017
80regulation of water loss via skin (GO:0033561)2.08613806
81regulation of histone deacetylation (GO:0031063)2.08314549
82definitive hemopoiesis (GO:0060216)2.07363169
83positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)2.07337109
84smooth muscle tissue development (GO:0048745)2.06271559
85regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.05590059
86keratinization (GO:0031424)2.05283682
87lateral sprouting from an epithelium (GO:0060601)2.05145536
88negative regulation of granulocyte differentiation (GO:0030853)2.03326777
89establishment of skin barrier (GO:0061436)2.01229403
90regulation of mesonephros development (GO:0061217)2.01005772
91regulation of axon extension involved in axon guidance (GO:0048841)1.99896920
92thymic T cell selection (GO:0045061)1.99055932
93dopaminergic neuron differentiation (GO:0071542)1.96975834
94positive regulation of type I interferon-mediated signaling pathway (GO:0060340)1.95520281
95response to prostaglandin (GO:0034694)1.95415055
96nephron tubule development (GO:0072080)1.94686663
97regulation of fatty acid oxidation (GO:0046320)1.94640172
98embryonic process involved in female pregnancy (GO:0060136)1.93863092
99regulation of glycogen (starch) synthase activity (GO:2000465)1.93309189
100embryonic camera-type eye morphogenesis (GO:0048596)1.93096436

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* HIF1A_21447827_ChIP-Seq_MCF-7_Human3.52401963
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.37592188
3* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.37008405
4ESR2_21235772_ChIP-Seq_MCF-7_Human2.21760564
5TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.18541428
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.17203884
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.06325939
8* MYC_22102868_ChIP-Seq_BL_Human2.06311187
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.04237677
10VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.00458744
11TCF7_22412390_ChIP-Seq_EML_Mouse1.91647318
12KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.91035185
13RARG_19884340_ChIP-ChIP_MEFs_Mouse1.90842648
14LXR_22292898_ChIP-Seq_THP-1_Human1.86172078
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.85069980
16STAT6_21828071_ChIP-Seq_BEAS2B_Human1.83993332
17BP1_19119308_ChIP-ChIP_Hs578T_Human1.76574875
18* KDM2B_26808549_Chip-Seq_DND41_Human1.74260494
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.73731673
20ELK3_25401928_ChIP-Seq_HUVEC_Human1.67235154
21VDR_21846776_ChIP-Seq_THP-1_Human1.63976239
22* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.62468736
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61448055
24NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.60295920
25EGR1_19374776_ChIP-ChIP_THP-1_Human1.57684285
26KDM2B_26808549_Chip-Seq_K562_Human1.56285985
27RACK7_27058665_Chip-Seq_MCF-7_Human1.56028068
28WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.55590192
29ESR1_21235772_ChIP-Seq_MCF-7_Human1.54195478
30RXR_22158963_ChIP-Seq_LIVER_Mouse1.51925504
31LXR_22158963_ChIP-Seq_LIVER_Mouse1.49395023
32EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.48817377
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48285520
34TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47230709
35SOX9_24532713_ChIP-Seq_HFSC_Mouse1.46901406
36KDM2B_26808549_Chip-Seq_JURKAT_Human1.46611949
37SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.44500186
38FOXO3_23340844_ChIP-Seq_DLD1_Human1.43907244
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42700182
40DROSHA_22980978_ChIP-Seq_HELA_Human1.42485891
41IRF8_22096565_ChIP-ChIP_GC-B_Human1.41655473
42FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.37543914
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.36834977
44ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35810425
45CLOCK_20551151_ChIP-Seq_293T_Human1.34125680
46FOXA2_19822575_ChIP-Seq_HepG2_Human1.32335703
47PPARA_22158963_ChIP-Seq_LIVER_Mouse1.31876273
48DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.29201297
49RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.27326552
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26171334
51ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.25924499
52SOX2_27498859_Chip-Seq_STOMACH_Mouse1.25889625
53CTNNB1_20460455_ChIP-Seq_HCT116_Human1.23264950
54E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22614146
55AHR_22903824_ChIP-Seq_MCF-7_Human1.21956827
56PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.21747257
57RUNX1_27514584_Chip-Seq_MCF-7_Human1.18859937
58VDR_24763502_ChIP-Seq_THP-1_Human1.18040898
59RUNX_20019798_ChIP-Seq_JUKART_Human1.17757346
60ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.17109123
61WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17050879
62ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15994554
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15408361
64FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.12188887
65EZH2_22144423_ChIP-Seq_EOC_Human1.11875518
66TBX20_22328084_ChIP-Seq_HEART_Mouse1.11012383
67TBX20_22080862_ChIP-Seq_HEART_Mouse1.11012383
68CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10763379
69RNF2_27304074_Chip-Seq_ESCs_Mouse1.10718519
70CREB1_26743006_Chip-Seq_LNCaP_Human1.10693488
71* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08772721
72CDX2_20551321_ChIP-Seq_CACO-2_Human1.08522002
73KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07856116
74P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05991403
75NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05725308
76ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05194674
77CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04991994
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04401711
79JARID2_20075857_ChIP-Seq_MESCs_Mouse1.02156049
80EZH2_18974828_ChIP-Seq_MESCs_Mouse1.01149762
81RNF2_18974828_ChIP-Seq_MESCs_Mouse1.01149762
82TP53_20018659_ChIP-ChIP_R1E_Mouse0.97964867
83MTF2_20144788_ChIP-Seq_MESCs_Mouse0.96418243
84P63_26484246_Chip-Seq_KERATINOCYTES_Human0.95344504
85UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94814651
86SA1_27219007_Chip-Seq_ERYTHROID_Human0.94793357
87SCL_19346495_ChIP-Seq_HPC-7_Human0.94492182
88VDR_24787735_ChIP-Seq_THP-1_Human0.93179081
89EP300_21415370_ChIP-Seq_HL-1_Mouse0.92633446
90PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91420697
91RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.91194450
92ARNT_22903824_ChIP-Seq_MCF-7_Human0.89809265
93ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89562261
94KLF5_25053715_ChIP-Seq_YYC3_Human0.89489412
95RING1B_27294783_Chip-Seq_ESCs_Mouse0.89333490
96TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89243881
97SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89111631
98ERG_21242973_ChIP-ChIP_JURKAT_Human0.87959709
99DNAJC2_21179169_ChIP-ChIP_NT2_Human0.87933921
100MAF_26560356_Chip-Seq_TH1_Human0.87835527

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.91131153
2MP0005275_abnormal_skin_tensile3.37290856
3MP0009379_abnormal_foot_pigmentation3.04098635
4MP0002138_abnormal_hepatobiliary_system2.84290109
5MP0005409_darkened_coat_color2.84079814
6MP0005503_abnormal_tendon_morphology2.72011064
7MP0010234_abnormal_vibrissa_follicle2.55342609
8MP0003705_abnormal_hypodermis_morpholog2.30190348
9MP0005257_abnormal_intraocular_pressure2.29599903
10MP0009780_abnormal_chondrocyte_physiolo2.14660673
11MP0000678_abnormal_parathyroid_gland2.12627391
12MP0003283_abnormal_digestive_organ2.10599097
13MP0000003_abnormal_adipose_tissue2.08396815
14MP0002909_abnormal_adrenal_gland2.07593766
15MP0002009_preneoplasia2.06252046
16MP0000013_abnormal_adipose_tissue2.00404441
17MP0004272_abnormal_basement_membrane1.92272792
18MP0005375_adipose_tissue_phenotype1.91668243
19MP0005666_abnormal_adipose_tissue1.86671061
20MP0001958_emphysema1.85596604
21MP0002139_abnormal_hepatobiliary_system1.84064511
22MP0001879_abnormal_lymphatic_vessel1.67137446
23MP0010678_abnormal_skin_adnexa1.66194794
24MP0005076_abnormal_cell_differentiation1.63858524
25MP0003183_abnormal_peptide_metabolism1.60360169
26MP0000383_abnormal_hair_follicle1.58392134
27MP0002060_abnormal_skin_morphology1.57791150
28MP0003878_abnormal_ear_physiology1.55691883
29MP0005377_hearing/vestibular/ear_phenot1.55691883
30MP0005670_abnormal_white_adipose1.53870678
31MP0010368_abnormal_lymphatic_system1.53126614
32MP0002166_altered_tumor_susceptibility1.41913103
33MP0000566_synostosis1.40475740
34MP0009278_abnormal_bone_marrow1.40397700
35MP0004264_abnormal_extraembryonic_tissu1.39143416
36MP0003091_abnormal_cell_migration1.37341289
37MP0002108_abnormal_muscle_morphology1.36030197
38MP0002876_abnormal_thyroid_physiology1.25451565
39MP0002396_abnormal_hematopoietic_system1.24211911
40MP0005360_urolithiasis1.23280008
41MP0001944_abnormal_pancreas_morphology1.22247109
42MP0002796_impaired_skin_barrier1.22099444
43MP0003045_fibrosis1.21977266
44MP0009053_abnormal_anal_canal1.21729988
45MP0003279_aneurysm1.19605300
46MP0003300_gastrointestinal_ulcer1.19472954
47MP0005023_abnormal_wound_healing1.18855422
48MP0005220_abnormal_exocrine_pancreas1.16349308
49MP0004885_abnormal_endolymph1.15290956
50MP0004185_abnormal_adipocyte_glucose1.13756471
51MP0002933_joint_inflammation1.13100279
52MP0002896_abnormal_bone_mineralization1.12985405
53MP0003453_abnormal_keratinocyte_physiol1.12337930
54MP0003868_abnormal_feces_composition1.12152501
55MP0003763_abnormal_thymus_physiology1.12040692
56MP0010329_abnormal_lipoprotein_level1.09961534
57MP0003115_abnormal_respiratory_system1.08640557
58MP0001666_abnormal_nutrient_absorption1.08088229
59MP0002971_abnormal_brown_adipose1.07621497
60MP0005508_abnormal_skeleton_morphology1.04708133
61MP0009384_cardiac_valve_regurgitation1.04406629
62MP0003942_abnormal_urinary_system1.01833744
63MP0002932_abnormal_joint_morphology1.00898320
64MP0001502_abnormal_circadian_rhythm1.00444277
65MP0002249_abnormal_larynx_morphology0.99534752
66MP0004019_abnormal_vitamin_homeostasis0.99235953
67MP0004947_skin_inflammation0.99105316
68MP0002998_abnormal_bone_remodeling0.98549766
69MP0000685_abnormal_immune_system0.97188475
70MP0003122_maternal_imprinting0.96331060
71MP0008961_abnormal_basal_metabolism0.95746424
72MP0000767_abnormal_smooth_muscle0.92113968
73MP0000681_abnormal_thyroid_gland0.91188538
74MP0009840_abnormal_foam_cell0.89553752
75MP0000613_abnormal_salivary_gland0.88543370
76MP0009115_abnormal_fat_cell0.86644295
77MP0009931_abnormal_skin_appearance0.86206019
78MP0004130_abnormal_muscle_cell0.86162493
79MP0005058_abnormal_lysosome_morphology0.85263537
80MP0002877_abnormal_melanocyte_morpholog0.84945545
81MP0003123_paternal_imprinting0.83799384
82MP0003879_abnormal_hair_cell0.83237514
83MP0001216_abnormal_epidermal_layer0.82385935
84MP0003566_abnormal_cell_adhesion0.81505301
85MP0005365_abnormal_bile_salt0.80853050
86MP0003191_abnormal_cellular_cholesterol0.80625517
87MP0000377_abnormal_hair_follicle0.78686579
88MP0000639_abnormal_adrenal_gland0.77745679
89MP0004808_abnormal_hematopoietic_stem0.76662990
90MP0000537_abnormal_urethra_morphology0.76309304
91MP0000762_abnormal_tongue_morphology0.76091115
92MP0002295_abnormal_pulmonary_circulatio0.74513255
93MP0002089_abnormal_postnatal_growth/wei0.73453546
94MP0002136_abnormal_kidney_physiology0.73366669
95MP0002135_abnormal_kidney_morphology0.72822886
96MP0001756_abnormal_urination0.72462555
97MP0002168_other_aberrant_phenotype0.70761415
98MP0010352_gastrointestinal_tract_polyps0.68490537
99MP0002116_abnormal_craniofacial_bone0.68367611
100MP0004381_abnormal_hair_follicle0.67974895

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.48340068
2Neonatal short-limb short stature (HP:0008921)3.37360270
3Obstructive sleep apnea (HP:0002870)2.94468332
4Increased IgE level (HP:0003212)2.76076616
5Premature rupture of membranes (HP:0001788)2.74032739
6Atrophic scars (HP:0001075)2.71812039
7Vascular tortuosity (HP:0004948)2.71112627
8Arterial tortuosity (HP:0005116)2.64256593
9Biconcave vertebral bodies (HP:0004586)2.55982784
10Segmental peripheral demyelination/remyelination (HP:0003481)2.53707872
11Genu recurvatum (HP:0002816)2.52801138
12Hyperextensible skin (HP:0000974)2.51877052
13Nuclear cataract (HP:0100018)2.49774855
14Soft skin (HP:0000977)2.42766479
15Aortic dissection (HP:0002647)2.41589980
16Bladder diverticulum (HP:0000015)2.37044300
17Shallow orbits (HP:0000586)2.36481220
18Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.29480798
19Asymmetry of the thorax (HP:0001555)2.29167367
20Fragile skin (HP:0001030)2.27541567
21Macroorchidism (HP:0000053)2.26820329
22Wormian bones (HP:0002645)2.26236496
23Morphological abnormality of the middle ear (HP:0008609)2.22909030
24Mitral valve prolapse (HP:0001634)2.21246238
25Abnormality of the nasal septum (HP:0000419)2.17497359
26Emphysema (HP:0002097)2.13311867
27Abnormality of incisor morphology (HP:0011063)2.12632014
28Enlarged penis (HP:0000040)2.09660148
29Flat acetabular roof (HP:0003180)2.08892322
30Natal tooth (HP:0000695)2.04519290
31Persistence of primary teeth (HP:0006335)2.04162304
32Hypoplasia of the iris (HP:0007676)2.02581226
33Striae distensae (HP:0001065)2.02546634
34Cerebral aneurysm (HP:0004944)2.02102411
35Mild short stature (HP:0003502)2.02087852
36Joint laxity (HP:0001388)1.99705648
37Cervical subluxation (HP:0003308)1.98960129
38Wide anterior fontanel (HP:0000260)1.98663687
39Deep palmar crease (HP:0006191)1.97232926
40Gastrointestinal stroma tumor (HP:0100723)1.94877920
41Broad metatarsal (HP:0001783)1.93920124
42Germ cell neoplasia (HP:0100728)1.93170465
43Aortic regurgitation (HP:0001659)1.92851951
44Advanced eruption of teeth (HP:0006288)1.92826935
45Turricephaly (HP:0000262)1.92676437
46Abnormality of the radial head (HP:0003995)1.92028541
47Vertebral compression fractures (HP:0002953)1.91714612
48Deep venous thrombosis (HP:0002625)1.91492233
49Osteoarthritis (HP:0002758)1.91158183
50Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.91021426
51Hypercortisolism (HP:0001578)1.89540549
52Bronchomalacia (HP:0002780)1.88877620
53Hyperacusis (HP:0010780)1.87610572
54Thin bony cortex (HP:0002753)1.87520306
55Abnormality of dentin (HP:0010299)1.84740384
56Aneurysm (HP:0002617)1.83931913
57Agammaglobulinemia (HP:0004432)1.82374059
58Cubitus valgus (HP:0002967)1.81386479
59Spinal canal stenosis (HP:0003416)1.81358100
60Rectal prolapse (HP:0002035)1.80929182
61Dilatation of the ascending aorta (HP:0005111)1.80419990
62Growth hormone excess (HP:0000845)1.78786622
63Dislocated radial head (HP:0003083)1.78404120
64Abnormality of complement system (HP:0005339)1.78276507
65Right ventricular cardiomyopathy (HP:0011663)1.76982250
66Abnormal pancreas size (HP:0012094)1.76928245
67Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.75972601
68Mitral regurgitation (HP:0001653)1.75642943
69Urinary glycosaminoglycan excretion (HP:0003541)1.75273676
70Mucopolysacchariduria (HP:0008155)1.75273676
71Complement deficiency (HP:0004431)1.74855301
72Acanthosis nigricans (HP:0000956)1.74852538
73Lip pit (HP:0100267)1.74736669
74Blue sclerae (HP:0000592)1.73464631
75Facial shape deformation (HP:0011334)1.71689692
76Potter facies (HP:0002009)1.71689692
77Decreased circulating renin level (HP:0003351)1.71494352
78Broad face (HP:0000283)1.70974261
79Testicular neoplasm (HP:0010788)1.69101723
80Abnormality of the fingertips (HP:0001211)1.66505417
81Hyperkalemia (HP:0002153)1.65834352
82Aortic aneurysm (HP:0004942)1.65720022
83Glomerulonephritis (HP:0000099)1.63938000
84Tibial bowing (HP:0002982)1.63350774
85Craniofacial hyperostosis (HP:0004493)1.63201899
86Abnormality of mucopolysaccharide metabolism (HP:0011020)1.59859865
87Abnormality of polysaccharide metabolism (HP:0011012)1.59859865
88Abnormality of glycosaminoglycan metabolism (HP:0004371)1.59859865
89Lymphangioma (HP:0100764)1.59430437
90Alopecia of scalp (HP:0002293)1.59095638
91Cupped ribs (HP:0000887)1.58841103
92Sprengel anomaly (HP:0000912)1.58198885
93Visceral angiomatosis (HP:0100761)1.57319341
94Colitis (HP:0002583)1.55087810
95Nephritis (HP:0000123)1.54900960
96Glucose intolerance (HP:0000833)1.52953256
97Cellulitis (HP:0100658)1.52623243
98Peritonitis (HP:0002586)1.52364241
99Onion bulb formation (HP:0003383)1.52084409
100Menstrual irregularities (HP:0000858)1.51404929

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.70380357
2PKN23.37073982
3ERN12.87804379
4PRPF4B2.73302025
5SIK12.50400205
6EEF2K2.35914571
7MAP3K132.12334354
8CDK122.03913034
9SIK22.01814991
10ICK1.94006189
11FGFR41.93396803
12FGFR31.87418003
13HIPK21.79738182
14RIPK11.73183316
15PRKD21.60075309
16MAP4K11.53446539
17MAP3K91.44948940
18MAP3K71.43887266
19MAP3K101.42493537
20PDGFRA1.42011404
21SMG11.40626829
22STK241.35621807
23FLT31.35262149
24NLK1.35156929
25SGK2231.33086150
26SGK4941.33086150
27MAPK111.27467314
28TRPM71.23014634
29MOS1.22426468
30FGFR21.21586957
31MARK21.20667994
32KIT1.20049723
33MTOR1.16813207
34PASK1.15584381
35MAP3K21.15138323
36CDC42BPA1.14312815
37MAP2K21.14032650
38MAP3K61.11979277
39MAP3K31.10836101
40LATS11.08356683
41MAP2K61.08168547
42RET1.06966217
43EPHA31.05112565
44NTRK11.01786266
45EPHB10.98711463
46SGK30.98329724
47MAPK70.95074923
48SGK20.93077809
49DDR20.91723542
50RPS6KC10.85745502
51RPS6KL10.85745502
52STK380.83575510
53RPS6KA20.80464944
54NEK90.80414790
55LRRK20.80188263
56CSF1R0.77496186
57PTK60.77065378
58MAPK150.76378644
59PDGFRB0.75814473
60CDK90.75804816
61JAK10.74414690
62ARAF0.72618027
63TBK10.72065668
64RPS6KA60.71741835
65ZAP700.69398570
66EPHB20.69128992
67MAPKAPK30.66875996
68MAP3K10.66785374
69MAP3K140.66233253
70MELK0.65153051
71BRD40.63230770
72PDPK10.63224492
73EPHA20.62522413
74AKT30.62098506
75TNK20.61184265
76PDK10.59014493
77PRKD30.57335133
78CHUK0.56670341
79KSR20.54946576
80CAMKK10.54904701
81PTK20.53501986
82TNIK0.52219947
83WNK10.52219300
84MAPK120.51515671
85PRKCH0.51406121
86TYRO30.51194840
87MAPK30.49000172
88IKBKB0.48349981
89TYK20.47855959
90SIK30.46284223
91RPS6KB20.46231425
92IRAK10.43351672
93LMTK20.42331201
94MAP2K30.41985038
95PRKAA10.40719768
96HCK0.40067564
97CDK40.39817980
98MAPK10.39448021
99IKBKE0.38576856
100MAPK40.37760046

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.19457703
2Dorso-ventral axis formation_Homo sapiens_hsa043202.02828190
3Protein digestion and absorption_Homo sapiens_hsa049741.77031677
4B cell receptor signaling pathway_Homo sapiens_hsa046621.74869835
5Notch signaling pathway_Homo sapiens_hsa043301.72737821
6Maturity onset diabetes of the young_Homo sapiens_hsa049501.67881381
7Other glycan degradation_Homo sapiens_hsa005111.62508102
8Renal cell carcinoma_Homo sapiens_hsa052111.61678105
9AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.47708003
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.47577116
11mTOR signaling pathway_Homo sapiens_hsa041501.43615868
12Acute myeloid leukemia_Homo sapiens_hsa052211.32229228
13Cyanoamino acid metabolism_Homo sapiens_hsa004601.30337615
14Chronic myeloid leukemia_Homo sapiens_hsa052201.27989659
15Non-small cell lung cancer_Homo sapiens_hsa052231.24497216
16ECM-receptor interaction_Homo sapiens_hsa045121.22626018
17Insulin resistance_Homo sapiens_hsa049311.17762924
18VEGF signaling pathway_Homo sapiens_hsa043701.17747039
19Carbohydrate digestion and absorption_Homo sapiens_hsa049731.17087814
20Pancreatic cancer_Homo sapiens_hsa052121.15374962
21Circadian rhythm_Homo sapiens_hsa047101.13784203
22Type II diabetes mellitus_Homo sapiens_hsa049301.12977828
23Focal adhesion_Homo sapiens_hsa045101.10941357
24Central carbon metabolism in cancer_Homo sapiens_hsa052301.09451728
25HIF-1 signaling pathway_Homo sapiens_hsa040661.07637841
26Lysine degradation_Homo sapiens_hsa003101.02697156
27Starch and sucrose metabolism_Homo sapiens_hsa005001.02545531
28Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02236147
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01797748
30Prolactin signaling pathway_Homo sapiens_hsa049170.99987713
31Endometrial cancer_Homo sapiens_hsa052130.99082439
32Fructose and mannose metabolism_Homo sapiens_hsa000510.97455388
33Pancreatic secretion_Homo sapiens_hsa049720.97374723
34Phospholipase D signaling pathway_Homo sapiens_hsa040720.96243407
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94165114
36Neurotrophin signaling pathway_Homo sapiens_hsa047220.93579576
37Intestinal immune network for IgA production_Homo sapiens_hsa046720.93106498
38Prostate cancer_Homo sapiens_hsa052150.92275923
39Insulin signaling pathway_Homo sapiens_hsa049100.92171356
40GnRH signaling pathway_Homo sapiens_hsa049120.91680334
41Choline metabolism in cancer_Homo sapiens_hsa052310.90876623
42Glycosaminoglycan degradation_Homo sapiens_hsa005310.90695540
43Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90321914
44MicroRNAs in cancer_Homo sapiens_hsa052060.86862795
45Complement and coagulation cascades_Homo sapiens_hsa046100.84759738
46Amoebiasis_Homo sapiens_hsa051460.82733361
47Small cell lung cancer_Homo sapiens_hsa052220.82058093
48ErbB signaling pathway_Homo sapiens_hsa040120.81920331
49Fat digestion and absorption_Homo sapiens_hsa049750.80335921
50Type I diabetes mellitus_Homo sapiens_hsa049400.80120801
51T cell receptor signaling pathway_Homo sapiens_hsa046600.79679916
52Staphylococcus aureus infection_Homo sapiens_hsa051500.79323105
53Bladder cancer_Homo sapiens_hsa052190.77955086
54Hepatitis C_Homo sapiens_hsa051600.76470690
55Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75865996
56Inositol phosphate metabolism_Homo sapiens_hsa005620.75305382
57Histidine metabolism_Homo sapiens_hsa003400.75104712
58Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74723142
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73349313
60ABC transporters_Homo sapiens_hsa020100.72129292
61AMPK signaling pathway_Homo sapiens_hsa041520.71402776
62Ovarian steroidogenesis_Homo sapiens_hsa049130.71045294
63FoxO signaling pathway_Homo sapiens_hsa040680.70248711
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.70182888
65Proteoglycans in cancer_Homo sapiens_hsa052050.69880384
66Allograft rejection_Homo sapiens_hsa053300.68398385
67Asthma_Homo sapiens_hsa053100.68310668
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67801326
69Bile secretion_Homo sapiens_hsa049760.67454546
70Toxoplasmosis_Homo sapiens_hsa051450.67021854
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66927373
72Autoimmune thyroid disease_Homo sapiens_hsa053200.66501619
73Ras signaling pathway_Homo sapiens_hsa040140.66479990
74Renin-angiotensin system_Homo sapiens_hsa046140.65124936
75Thyroid hormone synthesis_Homo sapiens_hsa049180.64808998
76Insulin secretion_Homo sapiens_hsa049110.64285207
77Glucagon signaling pathway_Homo sapiens_hsa049220.63534809
78Glioma_Homo sapiens_hsa052140.63455051
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62804027
80Pathways in cancer_Homo sapiens_hsa052000.62061285
81PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61566855
82Renin secretion_Homo sapiens_hsa049240.61330370
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.60405329
84Galactose metabolism_Homo sapiens_hsa000520.59705833
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59197175
86PPAR signaling pathway_Homo sapiens_hsa033200.59149210
87Estrogen signaling pathway_Homo sapiens_hsa049150.58289308
88Platelet activation_Homo sapiens_hsa046110.58078938
89Long-term potentiation_Homo sapiens_hsa047200.56163555
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55727556
91Glycerolipid metabolism_Homo sapiens_hsa005610.54852192
92Long-term depression_Homo sapiens_hsa047300.54624169
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54467717
94Vitamin digestion and absorption_Homo sapiens_hsa049770.53737685
95Retinol metabolism_Homo sapiens_hsa008300.53496740
96MAPK signaling pathway_Homo sapiens_hsa040100.53034258
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.53032951
98Linoleic acid metabolism_Homo sapiens_hsa005910.52745803
99Thyroid cancer_Homo sapiens_hsa052160.52180936
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52040200

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