ZNF385C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)4.96430251
2behavioral response to nicotine (GO:0035095)4.74240759
3cellular ketone body metabolic process (GO:0046950)4.50519109
4protein polyglutamylation (GO:0018095)4.17755662
5ketone body metabolic process (GO:1902224)4.04031265
6fucose catabolic process (GO:0019317)4.01402122
7L-fucose metabolic process (GO:0042354)4.01402122
8L-fucose catabolic process (GO:0042355)4.01402122
9tryptophan catabolic process (GO:0006569)3.95358595
10indole-containing compound catabolic process (GO:0042436)3.95358595
11indolalkylamine catabolic process (GO:0046218)3.95358595
12sperm motility (GO:0030317)3.80639764
13indolalkylamine metabolic process (GO:0006586)3.74860402
14kynurenine metabolic process (GO:0070189)3.70237787
15axoneme assembly (GO:0035082)3.69317222
16DNA deamination (GO:0045006)3.62916167
17detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.62253537
18detection of light stimulus involved in sensory perception (GO:0050962)3.60381127
19detection of light stimulus involved in visual perception (GO:0050908)3.60381127
20cilium or flagellum-dependent cell motility (GO:0001539)3.50607555
21regulation of cilium movement (GO:0003352)3.49482179
22piRNA metabolic process (GO:0034587)3.41037451
23tryptophan metabolic process (GO:0006568)3.40564401
24multicellular organism reproduction (GO:0032504)3.31720386
25preassembly of GPI anchor in ER membrane (GO:0016254)3.31466893
26acrosome reaction (GO:0007340)3.31406283
27retinal cone cell development (GO:0046549)3.27284859
28DNA double-strand break processing (GO:0000729)3.25972684
29water-soluble vitamin biosynthetic process (GO:0042364)3.23735661
30platelet dense granule organization (GO:0060155)3.21847738
31epithelial cilium movement (GO:0003351)3.18689093
32protein-cofactor linkage (GO:0018065)3.15821700
33epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.05988131
34DNA methylation involved in gamete generation (GO:0043046)3.04961490
35gamma-aminobutyric acid transport (GO:0015812)3.04622802
36photoreceptor cell maintenance (GO:0045494)3.01647434
37G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.97138056
38nonmotile primary cilium assembly (GO:0035058)2.95902970
39respiratory chain complex IV assembly (GO:0008535)2.93789743
40protein complex biogenesis (GO:0070271)2.90699199
41single strand break repair (GO:0000012)2.88906579
42L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.88218190
43mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.85633934
44mitochondrial respiratory chain complex I assembly (GO:0032981)2.85633934
45NADH dehydrogenase complex assembly (GO:0010257)2.85633934
46indole-containing compound metabolic process (GO:0042430)2.83805822
47cellular biogenic amine catabolic process (GO:0042402)2.79317216
48amine catabolic process (GO:0009310)2.79317216
49spermatid development (GO:0007286)2.77909594
50reciprocal DNA recombination (GO:0035825)2.74696517
51reciprocal meiotic recombination (GO:0007131)2.74696517
52GPI anchor metabolic process (GO:0006505)2.73849641
53neuronal action potential propagation (GO:0019227)2.73172060
54cell wall macromolecule metabolic process (GO:0044036)2.72390546
55negative regulation of cytosolic calcium ion concentration (GO:0051481)2.72310426
56establishment of protein localization to Golgi (GO:0072600)2.71977178
57cilium movement (GO:0003341)2.71940520
58regulation of microtubule-based movement (GO:0060632)2.71519153
59NAD biosynthetic process (GO:0009435)2.71395624
60cytochrome complex assembly (GO:0017004)2.71114938
61auditory receptor cell stereocilium organization (GO:0060088)2.70997459
62mannosylation (GO:0097502)2.69285699
63rhodopsin mediated signaling pathway (GO:0016056)2.67612643
64cilium organization (GO:0044782)2.66140802
65replication fork processing (GO:0031297)2.65914633
66protein K11-linked deubiquitination (GO:0035871)2.65735988
67mitochondrial respiratory chain complex assembly (GO:0033108)2.63530070
68cilium morphogenesis (GO:0060271)2.61993908
69protein localization to cilium (GO:0061512)2.61846726
70C4-dicarboxylate transport (GO:0015740)2.61391283
71reflex (GO:0060004)2.60195519
72cell wall macromolecule catabolic process (GO:0016998)2.59964732
73neuronal action potential (GO:0019228)2.59248366
74cilium assembly (GO:0042384)2.59052630
75negative regulation of telomere maintenance (GO:0032205)2.58570700
76rRNA modification (GO:0000154)2.58353537
77organic cation transport (GO:0015695)2.57233502
78behavioral response to ethanol (GO:0048149)2.56193008
79synaptic transmission, cholinergic (GO:0007271)2.55475488
80regulation of rhodopsin mediated signaling pathway (GO:0022400)2.54019395
81rRNA methylation (GO:0031167)2.53798929
82L-methionine biosynthetic process (GO:0071265)2.50379999
83amino acid salvage (GO:0043102)2.50379999
84L-methionine salvage (GO:0071267)2.50379999
85cornea development in camera-type eye (GO:0061303)2.50358536
86RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.49364707
87tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.49364707
88primary amino compound metabolic process (GO:1901160)2.49125307
89recombinational repair (GO:0000725)2.48041125
90photoreceptor cell development (GO:0042461)2.46359177
91double-strand break repair via homologous recombination (GO:0000724)2.46289665
92proline transport (GO:0015824)2.44437095
93inositol phosphate catabolic process (GO:0071545)2.43200591
94calcium ion-dependent exocytosis (GO:0017156)2.42224768
95sulfation (GO:0051923)2.40967542
96seminiferous tubule development (GO:0072520)2.40722757
97neural tube formation (GO:0001841)2.39825286
98negative regulation of synaptic transmission, GABAergic (GO:0032229)2.39752215
99male meiosis I (GO:0007141)2.39154915
100pyrimidine nucleobase catabolic process (GO:0006208)2.38071324

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.76831960
2VDR_22108803_ChIP-Seq_LS180_Human3.25656562
3GBX2_23144817_ChIP-Seq_PC3_Human2.86071221
4IGF1R_20145208_ChIP-Seq_DFB_Human2.76441965
5EZH2_22144423_ChIP-Seq_EOC_Human2.76021442
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.54872705
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36116010
8FUS_26573619_Chip-Seq_HEK293_Human2.27543642
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.26468903
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.23659172
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.18779410
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.16491246
13EWS_26573619_Chip-Seq_HEK293_Human2.07248516
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.04096555
15P300_19829295_ChIP-Seq_ESCs_Human1.99022236
16TAF15_26573619_Chip-Seq_HEK293_Human1.98393435
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.97919682
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.90361821
19EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.90215559
20ER_23166858_ChIP-Seq_MCF-7_Human1.90176533
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89646184
22IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.76272300
23CBP_20019798_ChIP-Seq_JUKART_Human1.76272300
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.74421097
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60613569
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60038127
27UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57048267
28TP53_22573176_ChIP-Seq_HFKS_Human1.56549525
29IRF1_19129219_ChIP-ChIP_H3396_Human1.55030778
30POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.53782258
31TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53782258
32STAT3_23295773_ChIP-Seq_U87_Human1.51386380
33REST_21632747_ChIP-Seq_MESCs_Mouse1.50501645
34SMAD4_21799915_ChIP-Seq_A2780_Human1.48815113
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46569166
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46119553
37BCAT_22108803_ChIP-Seq_LS180_Human1.43959618
38KLF5_20875108_ChIP-Seq_MESCs_Mouse1.41782086
39SOX2_19829295_ChIP-Seq_ESCs_Human1.41698790
40NANOG_19829295_ChIP-Seq_ESCs_Human1.41698790
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41230592
42ETV2_25802403_ChIP-Seq_MESCs_Mouse1.39745813
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39455466
44AR_25329375_ChIP-Seq_VCAP_Human1.39255297
45TCF4_23295773_ChIP-Seq_U87_Human1.39195067
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34806342
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.33730770
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33730770
49GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.32560443
50TCF4_22108803_ChIP-Seq_LS180_Human1.31912820
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30899139
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29179930
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28711848
54GATA3_21878914_ChIP-Seq_MCF-7_Human1.28330499
55NCOR_22424771_ChIP-Seq_293T_Human1.28097908
56GABP_17652178_ChIP-ChIP_JURKAT_Human1.27422551
57RUNX2_22187159_ChIP-Seq_PCA_Human1.26873722
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26378394
59NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25560336
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.25196668
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23546967
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.23395782
63BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22646370
64FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21196151
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.21187532
66EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21096556
67MYC_18940864_ChIP-ChIP_HL60_Human1.21054967
68SMAD4_21741376_ChIP-Seq_EPCs_Human1.18533840
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18328742
70RNF2_27304074_Chip-Seq_NSC_Mouse1.17037001
71HOXB7_26014856_ChIP-Seq_BT474_Human1.16935693
72MYC_19829295_ChIP-Seq_ESCs_Human1.14858655
73AR_20517297_ChIP-Seq_VCAP_Human1.13023604
74FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12934983
75AUTS2_25519132_ChIP-Seq_293T-REX_Human1.12910384
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11798786
77ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11792098
78ERA_21632823_ChIP-Seq_H3396_Human1.11709989
79RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09101059
80FLI1_21867929_ChIP-Seq_TH2_Mouse1.08552013
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.08533441
82PRDM14_20953172_ChIP-Seq_ESCs_Human1.07040484
83KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.06522350
84REST_18959480_ChIP-ChIP_MESCs_Mouse1.06506450
85NANOG_20526341_ChIP-Seq_ESCs_Human1.06412790
86EZH2_27294783_Chip-Seq_NPCs_Mouse1.05904428
87PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05706264
88AR_21572438_ChIP-Seq_LNCaP_Human1.05397895
89NOTCH1_21737748_ChIP-Seq_TLL_Human1.05086125
90EST1_17652178_ChIP-ChIP_JURKAT_Human1.04558272
91CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03342683
92TAF2_19829295_ChIP-Seq_ESCs_Human1.01459171
93FOXH1_21741376_ChIP-Seq_EPCs_Human1.00704193
94CDX2_22108803_ChIP-Seq_LS180_Human1.00163684
95NANOG_18555785_Chip-Seq_ESCs_Mouse0.99268259
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97161215
97OCT4_20526341_ChIP-Seq_ESCs_Human0.96690386
98OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95291096
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95051928
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95007108

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation2.78592411
2MP0003787_abnormal_imprinting2.62330833
3MP0001968_abnormal_touch/_nociception2.56529303
4MP0005410_abnormal_fertilization2.53615712
5MP0005551_abnormal_eye_electrophysiolog2.50173352
6MP0006292_abnormal_olfactory_placode2.33760814
7MP0003646_muscle_fatigue2.24745805
8MP0009046_muscle_twitch2.15593478
9MP0003880_abnormal_central_pattern2.08533760
10MP0003195_calcinosis2.03162090
11MP0005646_abnormal_pituitary_gland2.03039052
12MP0001986_abnormal_taste_sensitivity1.97458780
13MP0008875_abnormal_xenobiotic_pharmacok1.91160577
14MP0002736_abnormal_nociception_after1.91021939
15MP0005645_abnormal_hypothalamus_physiol1.89606113
16MP0009745_abnormal_behavioral_response1.86835241
17MP0002837_dystrophic_cardiac_calcinosis1.85829530
18MP0005253_abnormal_eye_physiology1.84704619
19MP0006072_abnormal_retinal_apoptosis1.83654632
20MP0004043_abnormal_pH_regulation1.81986493
21MP0008872_abnormal_physiological_respon1.81552458
22MP0002272_abnormal_nervous_system1.78088674
23MP0006276_abnormal_autonomic_nervous1.73811575
24MP0001486_abnormal_startle_reflex1.72993464
25MP0001984_abnormal_olfaction1.71646491
26MP0002638_abnormal_pupillary_reflex1.69891788
27MP0005377_hearing/vestibular/ear_phenot1.67102221
28MP0003878_abnormal_ear_physiology1.67102221
29MP0003011_delayed_dark_adaptation1.67100705
30MP0001501_abnormal_sleep_pattern1.65359261
31MP0002876_abnormal_thyroid_physiology1.60350886
32MP0002102_abnormal_ear_morphology1.55033147
33MP0000372_irregular_coat_pigmentation1.54259005
34MP0001485_abnormal_pinna_reflex1.54240384
35MP0004142_abnormal_muscle_tone1.53863226
36MP0002234_abnormal_pharynx_morphology1.48930077
37MP0004147_increased_porphyrin_level1.48153247
38MP0002163_abnormal_gland_morphology1.45623403
39MP0000427_abnormal_hair_cycle1.43439406
40MP0005174_abnormal_tail_pigmentation1.43294085
41MP0004885_abnormal_endolymph1.41581591
42MP0002735_abnormal_chemical_nociception1.39917734
43MP0003698_abnormal_male_reproductive1.39447350
44MP0002653_abnormal_ependyma_morphology1.38260343
45MP0002572_abnormal_emotion/affect_behav1.37343168
46MP0003121_genomic_imprinting1.36644996
47MP0002138_abnormal_hepatobiliary_system1.35313844
48MP0000631_abnormal_neuroendocrine_gland1.33081003
49MP0002557_abnormal_social/conspecific_i1.32616150
50MP0000569_abnormal_digit_pigmentation1.31890522
51MP0005379_endocrine/exocrine_gland_phen1.30216801
52MP0005423_abnormal_somatic_nervous1.29744366
53MP0004145_abnormal_muscle_electrophysio1.28890413
54MP0002064_seizures1.27129597
55MP0002160_abnormal_reproductive_system1.26253951
56MP0003136_yellow_coat_color1.24476435
57MP0005084_abnormal_gallbladder_morpholo1.23260196
58MP0003635_abnormal_synaptic_transmissio1.23150725
59MP0001970_abnormal_pain_threshold1.22532117
60MP0001929_abnormal_gametogenesis1.21539590
61MP0001529_abnormal_vocalization1.20212131
62MP0003718_maternal_effect1.18139413
63MP0010386_abnormal_urinary_bladder1.17239925
64MP0002733_abnormal_thermal_nociception1.16773630
65MP0001764_abnormal_homeostasis1.14961722
66MP0004742_abnormal_vestibular_system1.12053062
67MP0002938_white_spotting1.12037897
68MP0003122_maternal_imprinting1.11755315
69MP0004133_heterotaxia1.11168357
70MP0002067_abnormal_sensory_capabilities1.10941332
71MP0008789_abnormal_olfactory_epithelium1.07931466
72MP0002063_abnormal_learning/memory/cond1.07362387
73MP0005075_abnormal_melanosome_morpholog1.06298114
74MP0001905_abnormal_dopamine_level1.05640809
75MP0005670_abnormal_white_adipose1.04454328
76MP0005389_reproductive_system_phenotype1.03616541
77MP0008995_early_reproductive_senescence1.02598290
78MP0002229_neurodegeneration1.01625106
79MP0005386_behavior/neurological_phenoty1.01231128
80MP0004924_abnormal_behavior1.01231128
81MP0002734_abnormal_mechanical_nocicepti0.99595469
82MP0005167_abnormal_blood-brain_barrier0.99433603
83MP0001502_abnormal_circadian_rhythm0.98248372
84MP0002822_catalepsy0.93999110
85MP0002928_abnormal_bile_duct0.93869667
86MP0008058_abnormal_DNA_repair0.93603934
87MP0001963_abnormal_hearing_physiology0.92433763
88MP0003137_abnormal_impulse_conducting0.92243438
89MP0002184_abnormal_innervation0.91900077
90MP0002210_abnormal_sex_determination0.91830786
91MP0005195_abnormal_posterior_eye0.90834307
92MP0002752_abnormal_somatic_nervous0.89215152
93MP0000230_abnormal_systemic_arterial0.87121027
94MP0000015_abnormal_ear_pigmentation0.86831943
95MP0002095_abnormal_skin_pigmentation0.86317582
96MP0000653_abnormal_sex_gland0.84071664
97MP0008775_abnormal_heart_ventricle0.83127885
98MP0005394_taste/olfaction_phenotype0.82680890
99MP0005499_abnormal_olfactory_system0.82680890
100MP0004215_abnormal_myocardial_fiber0.82253269

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.27652605
2Pancreatic fibrosis (HP:0100732)3.96460330
3Chronic hepatic failure (HP:0100626)3.89347498
4Congenital stationary night blindness (HP:0007642)3.78889175
5Molar tooth sign on MRI (HP:0002419)3.76794259
6Abnormality of midbrain morphology (HP:0002418)3.76794259
7True hermaphroditism (HP:0010459)3.73036107
8Attenuation of retinal blood vessels (HP:0007843)3.68189803
9Nephronophthisis (HP:0000090)3.62996478
10Abnormality of the renal medulla (HP:0100957)3.22994209
11Abnormal rod and cone electroretinograms (HP:0008323)3.09921674
12Abnormality of the renal cortex (HP:0011035)3.02071677
13Medial flaring of the eyebrow (HP:0010747)3.01264611
14Type II lissencephaly (HP:0007260)2.96205739
15Abolished electroretinogram (ERG) (HP:0000550)2.95025804
16Decreased central vision (HP:0007663)2.74974765
17Cystic liver disease (HP:0006706)2.71751180
18Pendular nystagmus (HP:0012043)2.69113867
19Bony spicule pigmentary retinopathy (HP:0007737)2.67975636
20Gaze-evoked nystagmus (HP:0000640)2.64542697
21Decreased electroretinogram (ERG) amplitude (HP:0000654)2.59096986
22Polydipsia (HP:0001959)2.50872512
23Abnormal drinking behavior (HP:0030082)2.50872512
24Progressive cerebellar ataxia (HP:0002073)2.50330381
25Gait imbalance (HP:0002141)2.45137963
26Tubular atrophy (HP:0000092)2.44786829
27Absent rod-and cone-mediated responses on ERG (HP:0007688)2.44199102
28Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.42989147
29Abnormality of alanine metabolism (HP:0010916)2.42989147
30Hyperalaninemia (HP:0003348)2.42989147
31Hyperventilation (HP:0002883)2.41509900
32Sclerocornea (HP:0000647)2.38278408
33Dynein arm defect of respiratory motile cilia (HP:0012255)2.38274738
34Absent/shortened dynein arms (HP:0200106)2.38274738
35Hyperglycinemia (HP:0002154)2.38050158
36Congenital primary aphakia (HP:0007707)2.36235718
37Methylmalonic acidemia (HP:0002912)2.34451413
38Nephrogenic diabetes insipidus (HP:0009806)2.34330026
39Febrile seizures (HP:0002373)2.28086361
40Lissencephaly (HP:0001339)2.25756584
41Hyperglycinuria (HP:0003108)2.23854994
42Increased corneal curvature (HP:0100692)2.22758430
43Keratoconus (HP:0000563)2.22758430
44Abnormal respiratory epithelium morphology (HP:0012253)2.22436455
45Abnormal respiratory motile cilium morphology (HP:0005938)2.22436455
46Abnormal biliary tract physiology (HP:0012439)2.19306094
47Bile duct proliferation (HP:0001408)2.19306094
48Aplasia/Hypoplasia of the tongue (HP:0010295)2.19241007
49Congenital hepatic fibrosis (HP:0002612)2.18845527
50Cerebellar dysplasia (HP:0007033)2.17790772
51Polyuria (HP:0000103)2.17532569
52Broad-based gait (HP:0002136)2.15715331
53Inability to walk (HP:0002540)2.15131321
54Methylmalonic aciduria (HP:0012120)2.13980816
55Abnormality of macular pigmentation (HP:0008002)2.13387375
56Anencephaly (HP:0002323)2.10915001
57Ketosis (HP:0001946)2.09944514
58Tubulointerstitial nephritis (HP:0001970)2.07682172
593-Methylglutaconic aciduria (HP:0003535)2.04739697
60Abnormality of the labia minora (HP:0012880)2.03801665
61Genital tract atresia (HP:0001827)2.01817530
62Acute necrotizing encephalopathy (HP:0006965)2.00977893
63Decreased circulating renin level (HP:0003351)1.99534912
64Retinal dysplasia (HP:0007973)1.99182405
65Abnormality of glycine metabolism (HP:0010895)1.98679670
66Abnormality of serine family amino acid metabolism (HP:0010894)1.98679670
67Renal cortical cysts (HP:0000803)1.97503975
68Constricted visual fields (HP:0001133)1.97357291
69Genetic anticipation (HP:0003743)1.97280606
70Congenital sensorineural hearing impairment (HP:0008527)1.97165259
71Optic nerve hypoplasia (HP:0000609)1.96202378
72Acute encephalopathy (HP:0006846)1.93103868
73Vaginal atresia (HP:0000148)1.92305493
74Mitochondrial inheritance (HP:0001427)1.92239827
75Male pseudohermaphroditism (HP:0000037)1.91784036
76Chorioretinal atrophy (HP:0000533)1.91592102
77Postaxial foot polydactyly (HP:0001830)1.90463376
78Occipital encephalocele (HP:0002085)1.88434992
79Increased CSF lactate (HP:0002490)1.88247519
80Optic disc pallor (HP:0000543)1.86870134
81Ketoacidosis (HP:0001993)1.86626520
82Colon cancer (HP:0003003)1.86427525
83Large for gestational age (HP:0001520)1.85953859
84Progressive macrocephaly (HP:0004481)1.85453615
85Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.85076761
86Small hand (HP:0200055)1.83963352
87Abnormal ciliary motility (HP:0012262)1.82836414
88Furrowed tongue (HP:0000221)1.82468181
89Retinitis pigmentosa (HP:0000510)1.81605016
90Abnormal urine output (HP:0012590)1.80491822
91Poor coordination (HP:0002370)1.78515026
92Hemiparesis (HP:0001269)1.76850702
93Focal motor seizures (HP:0011153)1.75763443
94Aplasia/Hypoplasia of the tibia (HP:0005772)1.74181345
95Hepatocellular necrosis (HP:0001404)1.74066905
96Progressive inability to walk (HP:0002505)1.73127259
97Hypothermia (HP:0002045)1.72460949
98Thyroid-stimulating hormone excess (HP:0002925)1.71284306
99Hepatic necrosis (HP:0002605)1.68304832
100Aplasia/Hypoplasia of the spleen (HP:0010451)1.67487520

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.11543366
2MAP4K23.66036853
3BMPR1B2.89891260
4ADRBK22.85339075
5NUAK12.67242901
6PINK12.59362739
7WNK32.57281324
8ZAK2.26159627
9WNK42.01928254
10INSRR1.98301608
11GRK11.97890705
12MAPK131.79135460
13ACVR1B1.77681526
14TRIM281.75427189
15TAOK31.72753688
16CASK1.71439780
17OXSR11.68417228
18BCKDK1.63876743
19MAP3K41.62695340
20STK391.56813823
21TLK11.51151825
22STK38L1.47547226
23PLK41.42528596
24DAPK21.35457893
25DYRK21.28307604
26TXK1.28141884
27PLK21.27540242
28PHKG11.26544731
29PHKG21.26544731
30MKNK21.24460089
31MAP2K61.11779412
32TIE11.08978494
33MARK11.04431994
34FGFR21.03928000
35PRKCE0.96709238
36CDK190.96066349
37TAF10.95490577
38PAK30.95420518
39MAP2K70.95020381
40CSNK1G30.94630599
41PRKCG0.94602720
42EPHA40.93435209
43CSNK1G20.92542993
44ADRBK10.91693963
45BCR0.90572231
46STK160.90041353
47CSNK1G10.88834183
48NTRK30.87267101
49VRK10.85228723
50MUSK0.82509127
51TNIK0.80101533
52CSNK1A1L0.78706652
53VRK20.73662154
54MAPK150.72809160
55EIF2AK30.72611011
56OBSCN0.70120825
57ERBB30.66484016
58TEC0.65268893
59CAMKK20.64688483
60NME10.64532120
61MKNK10.63811916
62MINK10.63044314
63TGFBR10.62882370
64KIT0.62819178
65FER0.60533730
66TNK20.59589941
67PTK2B0.57299264
68NTRK20.55810551
69GRK50.52579179
70PKN10.51762732
71PRKCQ0.51477281
72PLK30.51369210
73CSNK1A10.50882801
74FLT30.49141416
75CAMK2A0.48193190
76PRKACA0.47025737
77IKBKB0.46772879
78STK110.46381820
79CAMK10.46073491
80STK30.40774958
81PIK3CA0.40766546
82MST40.40627902
83PRKAA10.39648434
84PRKCI0.39051258
85ITK0.38418980
86RPS6KA50.37597272
87SGK2230.37569471
88SGK4940.37569471
89NEK20.37303461
90PRKAA20.37231023
91IRAK10.37051881
92PIK3CG0.36363436
93PRKG10.35865175
94CDK30.35476417
95PRKCA0.34948087
96ATR0.34804983
97MAPKAPK50.33905656
98CSNK1D0.33742639
99SGK20.33651058
100BRSK20.33566768

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.35641837
2Phototransduction_Homo sapiens_hsa047442.85101145
3Butanoate metabolism_Homo sapiens_hsa006502.69748848
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.67069025
5Linoleic acid metabolism_Homo sapiens_hsa005912.24431837
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.22677254
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.15667523
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.14421441
9Nicotine addiction_Homo sapiens_hsa050332.13332054
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.98973856
11Caffeine metabolism_Homo sapiens_hsa002321.98674348
12Nitrogen metabolism_Homo sapiens_hsa009101.96103201
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.87339280
14Homologous recombination_Homo sapiens_hsa034401.86865139
15Selenocompound metabolism_Homo sapiens_hsa004501.85753569
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.83407621
17Oxidative phosphorylation_Homo sapiens_hsa001901.82088384
18Tryptophan metabolism_Homo sapiens_hsa003801.80275596
19RNA polymerase_Homo sapiens_hsa030201.73588079
20Olfactory transduction_Homo sapiens_hsa047401.72076918
21Propanoate metabolism_Homo sapiens_hsa006401.71527840
22Fanconi anemia pathway_Homo sapiens_hsa034601.65234829
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.64815187
24Taste transduction_Homo sapiens_hsa047421.64469842
25Basal transcription factors_Homo sapiens_hsa030221.55699996
26Ether lipid metabolism_Homo sapiens_hsa005651.54711503
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.49848240
28One carbon pool by folate_Homo sapiens_hsa006701.40182995
29Morphine addiction_Homo sapiens_hsa050321.37511323
30Protein export_Homo sapiens_hsa030601.35678605
31Parkinsons disease_Homo sapiens_hsa050121.32910608
32Peroxisome_Homo sapiens_hsa041461.31695733
33Regulation of autophagy_Homo sapiens_hsa041401.21134312
34GABAergic synapse_Homo sapiens_hsa047271.16668774
35ABC transporters_Homo sapiens_hsa020101.15694845
36RNA degradation_Homo sapiens_hsa030181.14725929
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.13944276
38Circadian entrainment_Homo sapiens_hsa047131.11188768
39Glutamatergic synapse_Homo sapiens_hsa047241.05935516
40Huntingtons disease_Homo sapiens_hsa050161.02880627
41Chemical carcinogenesis_Homo sapiens_hsa052041.01866138
42Insulin secretion_Homo sapiens_hsa049111.01402974
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98337006
44Serotonergic synapse_Homo sapiens_hsa047260.97353993
45Primary bile acid biosynthesis_Homo sapiens_hsa001200.97006318
46Retinol metabolism_Homo sapiens_hsa008300.96948198
47Steroid hormone biosynthesis_Homo sapiens_hsa001400.94614156
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94518337
49Cardiac muscle contraction_Homo sapiens_hsa042600.94462020
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92225861
51Sulfur relay system_Homo sapiens_hsa041220.91768747
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91072750
53beta-Alanine metabolism_Homo sapiens_hsa004100.89769962
54Salivary secretion_Homo sapiens_hsa049700.88803334
55Arachidonic acid metabolism_Homo sapiens_hsa005900.87279073
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.86979045
57Collecting duct acid secretion_Homo sapiens_hsa049660.85492174
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85229836
59Purine metabolism_Homo sapiens_hsa002300.85174535
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84715229
61Fatty acid degradation_Homo sapiens_hsa000710.84011773
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83944196
63Calcium signaling pathway_Homo sapiens_hsa040200.83512697
64Alzheimers disease_Homo sapiens_hsa050100.81286858
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78117457
66Non-homologous end-joining_Homo sapiens_hsa034500.75727173
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.75541442
68Metabolic pathways_Homo sapiens_hsa011000.74110729
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.69390589
70Fatty acid biosynthesis_Homo sapiens_hsa000610.68730551
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68027543
72Glycerolipid metabolism_Homo sapiens_hsa005610.67178854
73Type I diabetes mellitus_Homo sapiens_hsa049400.65050542
74Fatty acid metabolism_Homo sapiens_hsa012120.64165686
75Fat digestion and absorption_Homo sapiens_hsa049750.62942096
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.59190259
77Dopaminergic synapse_Homo sapiens_hsa047280.57793848
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.56727263
79Pyrimidine metabolism_Homo sapiens_hsa002400.54692034
80Arginine and proline metabolism_Homo sapiens_hsa003300.54576152
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53125008
82Ovarian steroidogenesis_Homo sapiens_hsa049130.52584772
83Circadian rhythm_Homo sapiens_hsa047100.51144445
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50431135
85Long-term depression_Homo sapiens_hsa047300.48184546
86RNA transport_Homo sapiens_hsa030130.45261698
87Histidine metabolism_Homo sapiens_hsa003400.43614597
88Mineral absorption_Homo sapiens_hsa049780.43390212
89Asthma_Homo sapiens_hsa053100.42769068
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41097093
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41030070
92Proteasome_Homo sapiens_hsa030500.38871623
93Dorso-ventral axis formation_Homo sapiens_hsa043200.38858875
94Synaptic vesicle cycle_Homo sapiens_hsa047210.36859363
95Lysine degradation_Homo sapiens_hsa003100.35979217
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.35935453
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35358496
98Base excision repair_Homo sapiens_hsa034100.35281119
99Fatty acid elongation_Homo sapiens_hsa000620.34691973
100Oxytocin signaling pathway_Homo sapiens_hsa049210.34389035

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