ZNF37BP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein K11-linked deubiquitination (GO:0035871)4.88493761
2indole-containing compound catabolic process (GO:0042436)4.68442372
3indolalkylamine catabolic process (GO:0046218)4.68442372
4tryptophan catabolic process (GO:0006569)4.68442372
5behavioral response to nicotine (GO:0035095)4.35291215
6kynurenine metabolic process (GO:0070189)4.25310470
7neural tube formation (GO:0001841)4.24556821
8indolalkylamine metabolic process (GO:0006586)4.23883625
9tryptophan metabolic process (GO:0006568)4.01677037
10monoubiquitinated protein deubiquitination (GO:0035520)3.99604890
11detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.97819803
12negative regulation of mast cell activation (GO:0033004)3.86402798
13cilium or flagellum-dependent cell motility (GO:0001539)3.72008205
14protein K48-linked deubiquitination (GO:0071108)3.66876753
15detection of light stimulus involved in visual perception (GO:0050908)3.65238049
16detection of light stimulus involved in sensory perception (GO:0050962)3.65238049
17interkinetic nuclear migration (GO:0022027)3.63954001
18L-fucose metabolic process (GO:0042354)3.61249179
19L-fucose catabolic process (GO:0042355)3.61249179
20fucose catabolic process (GO:0019317)3.61249179
21gamma-aminobutyric acid transport (GO:0015812)3.43005396
22establishment of protein localization to Golgi (GO:0072600)3.39988203
23signal peptide processing (GO:0006465)3.33903070
24reflex (GO:0060004)3.31130755
25regulation of hippo signaling (GO:0035330)3.27852469
26negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.27373506
27negative regulation of translation, ncRNA-mediated (GO:0040033)3.27373506
28regulation of translation, ncRNA-mediated (GO:0045974)3.27373506
29sulfation (GO:0051923)3.24944549
30indole-containing compound metabolic process (GO:0042430)3.24095642
31regulation of establishment of cell polarity (GO:2000114)3.21750260
32protein K63-linked deubiquitination (GO:0070536)3.14300622
33cellular ketone body metabolic process (GO:0046950)3.04516916
34lipid translocation (GO:0034204)3.00345636
35phospholipid translocation (GO:0045332)3.00345636
36DNA double-strand break processing (GO:0000729)2.96779421
37response to pheromone (GO:0019236)2.95765541
38negative regulation of cytosolic calcium ion concentration (GO:0051481)2.95627567
39photoreceptor cell maintenance (GO:0045494)2.95579299
40cellular response to sterol (GO:0036315)2.94328080
41serotonin metabolic process (GO:0042428)2.88250762
42cytoplasmic mRNA processing body assembly (GO:0033962)2.86013618
43activated T cell proliferation (GO:0050798)2.85719779
44neuronal action potential (GO:0019228)2.83194683
45rRNA catabolic process (GO:0016075)2.81831631
46positive regulation of developmental pigmentation (GO:0048087)2.80277650
47detection of mechanical stimulus involved in sensory perception (GO:0050974)2.79706562
48central nervous system neuron axonogenesis (GO:0021955)2.79704689
49retinal cone cell development (GO:0046549)2.79002873
50regulation of sarcomere organization (GO:0060297)2.77156864
51neuronal action potential propagation (GO:0019227)2.76704177
52sex differentiation (GO:0007548)2.76025861
53epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.75632917
54ketone body metabolic process (GO:1902224)2.75388704
55primary amino compound metabolic process (GO:1901160)2.75156388
56regulation of establishment or maintenance of cell polarity (GO:0032878)2.74088054
57startle response (GO:0001964)2.73586668
58NAD biosynthetic process (GO:0009435)2.73365580
59negative regulation of sodium ion transport (GO:0010766)2.73072986
60membrane depolarization during action potential (GO:0086010)2.72130465
61auditory receptor cell stereocilium organization (GO:0060088)2.71740790
62cerebellar Purkinje cell differentiation (GO:0021702)2.71432163
63thyroid hormone metabolic process (GO:0042403)2.71197445
64snRNA transcription (GO:0009301)2.69782545
65amine catabolic process (GO:0009310)2.68754098
66cellular biogenic amine catabolic process (GO:0042402)2.68754098
67axoneme assembly (GO:0035082)2.67680251
68histone H3-K9 methylation (GO:0051567)2.67548437
69central nervous system projection neuron axonogenesis (GO:0021952)2.67350237
70replication fork processing (GO:0031297)2.67282031
71negative regulation of calcium ion transport into cytosol (GO:0010523)2.66889497
72regulation of action potential (GO:0098900)2.65956204
73tachykinin receptor signaling pathway (GO:0007217)2.64784330
74behavioral response to ethanol (GO:0048149)2.63035624
75regulation of pigment cell differentiation (GO:0050932)2.61639489
76cAMP catabolic process (GO:0006198)2.60843679
77regulation of gene silencing by RNA (GO:0060966)2.60797484
78regulation of posttranscriptional gene silencing (GO:0060147)2.60797484
79regulation of gene silencing by miRNA (GO:0060964)2.60797484
80benzene-containing compound metabolic process (GO:0042537)2.60477245
81reciprocal meiotic recombination (GO:0007131)2.59768582
82reciprocal DNA recombination (GO:0035825)2.59768582
83adaptation of signaling pathway (GO:0023058)2.57392306
84regulation of memory T cell differentiation (GO:0043380)2.56602584
85membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.53185445
86phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.51855619
87inner ear receptor stereocilium organization (GO:0060122)2.50557555
88regulation of MHC class I biosynthetic process (GO:0045343)2.50043627
89positive regulation of oligodendrocyte differentiation (GO:0048714)2.48587741
90kidney morphogenesis (GO:0060993)2.48524803
91spinal cord motor neuron differentiation (GO:0021522)2.48376204
92interferon-gamma production (GO:0032609)2.48323238
93proline transport (GO:0015824)2.47492989
94G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.47406985
95transmission of nerve impulse (GO:0019226)2.46837657
96histone H3-K4 trimethylation (GO:0080182)2.45809464
97L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.45610650
98negative regulation of multicellular organism growth (GO:0040015)2.44256395
99protein localization to cilium (GO:0061512)2.44226407
100oxidative demethylation (GO:0070989)2.42760393

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.52162442
2EZH2_22144423_ChIP-Seq_EOC_Human3.22553716
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.04349868
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.01275528
5ZNF274_21170338_ChIP-Seq_K562_Hela2.79587961
6VDR_22108803_ChIP-Seq_LS180_Human2.77069080
7IGF1R_20145208_ChIP-Seq_DFB_Human2.76663463
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.64902416
9TAF15_26573619_Chip-Seq_HEK293_Human2.57120403
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.51100188
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.39235308
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.32111610
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.28133288
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.19430056
15SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.17176828
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.06778866
17FUS_26573619_Chip-Seq_HEK293_Human2.02815407
18AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.00117239
19P300_19829295_ChIP-Seq_ESCs_Human1.96885545
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94623216
21ER_23166858_ChIP-Seq_MCF-7_Human1.93639623
22EWS_26573619_Chip-Seq_HEK293_Human1.92572206
23STAT3_23295773_ChIP-Seq_U87_Human1.89675565
24AR_21572438_ChIP-Seq_LNCaP_Human1.89362881
25SMAD4_21799915_ChIP-Seq_A2780_Human1.76967389
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76879063
27BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.75934764
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72483006
29TCF4_23295773_ChIP-Seq_U87_Human1.68169205
30BCAT_22108803_ChIP-Seq_LS180_Human1.64058510
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.63832179
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.63061136
33MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.58514978
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.58060794
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54956689
36CBP_20019798_ChIP-Seq_JUKART_Human1.54956689
37AR_25329375_ChIP-Seq_VCAP_Human1.53173143
38DROSHA_22980978_ChIP-Seq_HELA_Human1.53159009
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.52164929
40TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52164929
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48527923
42NR3C1_21868756_ChIP-Seq_MCF10A_Human1.47270216
43REST_21632747_ChIP-Seq_MESCs_Mouse1.44333234
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.43272563
45TP53_16413492_ChIP-PET_HCT116_Human1.40823998
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.36806393
47FLI1_21867929_ChIP-Seq_TH2_Mouse1.34691218
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34007315
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33407719
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33134738
51RUNX2_22187159_ChIP-Seq_PCA_Human1.33030137
52PRDM14_20953172_ChIP-Seq_ESCs_Human1.32195739
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32064656
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30606261
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29695281
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28462575
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.28401541
58CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.28375439
59EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.27646130
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26281578
61TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.26274061
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26160053
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.26095097
64TCF4_22108803_ChIP-Seq_LS180_Human1.25769789
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.25743297
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.25624671
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25244500
68SMAD4_21741376_ChIP-Seq_EPCs_Human1.18648828
69RNF2_27304074_Chip-Seq_NSC_Mouse1.17546311
70TP53_22573176_ChIP-Seq_HFKS_Human1.17511545
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16670396
72CRX_20693478_ChIP-Seq_RETINA_Mouse1.15488237
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13614071
74P53_22387025_ChIP-Seq_ESCs_Mouse1.12064672
75IRF1_19129219_ChIP-ChIP_H3396_Human1.11351417
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.11289658
77TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10967674
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.10780867
79BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10486080
80RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09927296
81TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08622143
82OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08328653
83FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07120456
84E2F1_18555785_Chip-Seq_ESCs_Mouse1.06942540
85KDM2B_26808549_Chip-Seq_REH_Human1.06623266
86SOX2_19829295_ChIP-Seq_ESCs_Human1.04973755
87NANOG_19829295_ChIP-Seq_ESCs_Human1.04973755
88BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04212653
89NOTCH1_21737748_ChIP-Seq_TLL_Human1.02990947
90CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01824194
91SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01210681
92STAT3_18555785_Chip-Seq_ESCs_Mouse0.99860720
93TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99572116
94CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97550155
95JARID2_20064375_ChIP-Seq_MESCs_Mouse0.97031778
96SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95774611
97AHR_22903824_ChIP-Seq_MCF-7_Human0.95743343
98CMYC_18555785_Chip-Seq_ESCs_Mouse0.95720203
99RXR_22108803_ChIP-Seq_LS180_Human0.95633171
100CDX2_22108803_ChIP-Seq_LS180_Human0.95294160

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.40041744
2MP0003787_abnormal_imprinting2.87259419
3MP0008057_abnormal_DNA_replication2.81429608
4MP0008877_abnormal_DNA_methylation2.69736024
5MP0005551_abnormal_eye_electrophysiolog2.61377419
6MP0009046_muscle_twitch2.42309517
7MP0003195_calcinosis2.33227454
8MP0001968_abnormal_touch/_nociception2.27022193
9MP0009745_abnormal_behavioral_response2.19559089
10MP0005174_abnormal_tail_pigmentation2.14677858
11MP0001501_abnormal_sleep_pattern2.12054158
12MP0002837_dystrophic_cardiac_calcinosis2.06411191
13MP0003646_muscle_fatigue2.02851469
14MP0001986_abnormal_taste_sensitivity2.02471222
15MP0004043_abnormal_pH_regulation1.97653146
16MP0003880_abnormal_central_pattern1.93736631
17MP0001486_abnormal_startle_reflex1.90508352
18MP0002736_abnormal_nociception_after1.74890738
19MP0002064_seizures1.74534013
20MP0000427_abnormal_hair_cycle1.72186492
21MP0002272_abnormal_nervous_system1.70319369
22MP0004885_abnormal_endolymph1.67386635
23MP0004142_abnormal_muscle_tone1.64043639
24MP0005646_abnormal_pituitary_gland1.62910700
25MP0005253_abnormal_eye_physiology1.62562940
26MP0003635_abnormal_synaptic_transmissio1.62415913
27MP0006292_abnormal_olfactory_placode1.62355485
28MP0006276_abnormal_autonomic_nervous1.61471149
29MP0002102_abnormal_ear_morphology1.56032994
30MP0002572_abnormal_emotion/affect_behav1.53978688
31MP0001485_abnormal_pinna_reflex1.51524380
32MP0002735_abnormal_chemical_nociception1.51414235
33MP0002638_abnormal_pupillary_reflex1.48317411
34MP0004924_abnormal_behavior1.47774289
35MP0005386_behavior/neurological_phenoty1.47774289
36MP0002876_abnormal_thyroid_physiology1.47098319
37MP0006072_abnormal_retinal_apoptosis1.45744645
38MP0008872_abnormal_physiological_respon1.44049771
39MP0000631_abnormal_neuroendocrine_gland1.43591035
40MP0005645_abnormal_hypothalamus_physiol1.40961008
41MP0002063_abnormal_learning/memory/cond1.40059115
42MP0005310_abnormal_salivary_gland1.39901413
43MP0002067_abnormal_sensory_capabilities1.35692198
44MP0000778_abnormal_nervous_system1.32149062
45MP0001984_abnormal_olfaction1.30055698
46MP0002928_abnormal_bile_duct1.28576425
47MP0004742_abnormal_vestibular_system1.27276682
48MP0002557_abnormal_social/conspecific_i1.24259985
49MP0002938_white_spotting1.22226586
50MP0004130_abnormal_muscle_cell1.21701570
51MP0004145_abnormal_muscle_electrophysio1.20804881
52MP0001970_abnormal_pain_threshold1.20761561
53MP0003252_abnormal_bile_duct1.20091735
54MP0002138_abnormal_hepatobiliary_system1.19890666
55MP0004147_increased_porphyrin_level1.18272212
56MP0000383_abnormal_hair_follicle1.17841752
57MP0000372_irregular_coat_pigmentation1.16941416
58MP0002009_preneoplasia1.15683092
59MP0000371_diluted_coat_color1.15111537
60MP0002733_abnormal_thermal_nociception1.14400177
61MP0002095_abnormal_skin_pigmentation1.10495672
62MP0003121_genomic_imprinting1.09248515
63MP0003890_abnormal_embryonic-extraembry1.06880436
64MP0010386_abnormal_urinary_bladder1.03667398
65MP0005075_abnormal_melanosome_morpholog1.02314894
66MP0003045_fibrosis1.01665418
67MP0003136_yellow_coat_color0.98980186
68MP0005389_reproductive_system_phenotype0.97858162
69MP0005195_abnormal_posterior_eye0.97243207
70MP0002229_neurodegeneration0.96609490
71MP0001919_abnormal_reproductive_system0.94068781
72MP0003633_abnormal_nervous_system0.93184975
73MP0002882_abnormal_neuron_morphology0.91228495
74MP0002163_abnormal_gland_morphology0.90978830
75MP0002234_abnormal_pharynx_morphology0.90365314
76MP0002752_abnormal_somatic_nervous0.89127829
77MP0000955_abnormal_spinal_cord0.88499417
78MP0008875_abnormal_xenobiotic_pharmacok0.87846191
79MP0002653_abnormal_ependyma_morphology0.85622648
80MP0003183_abnormal_peptide_metabolism0.84573342
81MP0004859_abnormal_synaptic_plasticity0.83665648
82MP0003943_abnormal_hepatobiliary_system0.83656415
83MP0005171_absent_coat_pigmentation0.83337949
84MP0002734_abnormal_mechanical_nocicepti0.82206178
85MP0005423_abnormal_somatic_nervous0.81185036
86MP0008961_abnormal_basal_metabolism0.80937211
87MP0001963_abnormal_hearing_physiology0.80524749
88MP0003698_abnormal_male_reproductive0.79273743
89MP0000015_abnormal_ear_pigmentation0.78511521
90MP0002184_abnormal_innervation0.75927305
91MP0003631_nervous_system_phenotype0.75324673
92MP0001440_abnormal_grooming_behavior0.75080504
93MP0002160_abnormal_reproductive_system0.75052837
94MP0002168_other_aberrant_phenotype0.74605371
95MP0000230_abnormal_systemic_arterial0.71954475
96MP0004215_abnormal_myocardial_fiber0.67763308
97MP0002693_abnormal_pancreas_physiology0.67011267
98MP0005266_abnormal_metabolism0.66882518
99MP0003137_abnormal_impulse_conducting0.66510152
100MP0001324_abnormal_eye_pigmentation0.66113889

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)4.94508572
2Progressive cerebellar ataxia (HP:0002073)4.60873961
3Hyperventilation (HP:0002883)4.39236215
4Gaze-evoked nystagmus (HP:0000640)4.38819212
5Pancreatic cysts (HP:0001737)4.31516808
6Pancreatic fibrosis (HP:0100732)3.78058881
7Congenital stationary night blindness (HP:0007642)3.73143025
8True hermaphroditism (HP:0010459)3.62617526
9Molar tooth sign on MRI (HP:0002419)3.52085618
10Abnormality of midbrain morphology (HP:0002418)3.52085618
11Febrile seizures (HP:0002373)3.44537723
12Nephronophthisis (HP:0000090)3.39462186
13Attenuation of retinal blood vessels (HP:0007843)3.36378870
14Chronic hepatic failure (HP:0100626)3.22271626
15Abnormality of the renal cortex (HP:0011035)3.17770586
16Protruding tongue (HP:0010808)3.17757729
17Abnormality of the renal medulla (HP:0100957)3.08902781
18Fair hair (HP:0002286)2.97918059
19Focal seizures (HP:0007359)2.95430634
20Cystic liver disease (HP:0006706)2.84451396
21Absent speech (HP:0001344)2.76958258
22Medial flaring of the eyebrow (HP:0010747)2.66616418
23Dialeptic seizures (HP:0011146)2.65087295
24Clumsiness (HP:0002312)2.55012085
25Aplasia/Hypoplasia of the tibia (HP:0005772)2.50660355
26Broad-based gait (HP:0002136)2.46059230
27Focal motor seizures (HP:0011153)2.45962393
28Absence seizures (HP:0002121)2.45383280
29Bony spicule pigmentary retinopathy (HP:0007737)2.40931239
30Generalized hypopigmentation of hair (HP:0011358)2.39470286
31Abolished electroretinogram (ERG) (HP:0000550)2.28061387
32Keratoconus (HP:0000563)2.24812151
33Increased corneal curvature (HP:0100692)2.24812151
34Congenital sensorineural hearing impairment (HP:0008527)2.24636839
35Atonic seizures (HP:0010819)2.23275274
36Abnormal drinking behavior (HP:0030082)2.17032638
37Polydipsia (HP:0001959)2.17032638
38Decreased circulating renin level (HP:0003351)2.16864737
39Renal cortical cysts (HP:0000803)2.16799701
40Volvulus (HP:0002580)2.16600095
41Tubular atrophy (HP:0000092)2.15677919
42Gait imbalance (HP:0002141)2.15546160
43Congenital hepatic fibrosis (HP:0002612)2.12325006
44Aplasia/Hypoplasia of the tongue (HP:0010295)2.08733329
45Inability to walk (HP:0002540)2.07943245
46Type II lissencephaly (HP:0007260)2.07453740
47Stomach cancer (HP:0012126)2.07158888
48Widely spaced teeth (HP:0000687)2.07157725
49Drooling (HP:0002307)2.07059812
50Patellar aplasia (HP:0006443)2.05633682
51Epileptic encephalopathy (HP:0200134)2.05247789
52Hemiparesis (HP:0001269)2.04816183
53Abnormal rod and cone electroretinograms (HP:0008323)2.03750346
54Bile duct proliferation (HP:0001408)2.03403523
55Abnormal biliary tract physiology (HP:0012439)2.03403523
56Pendular nystagmus (HP:0012043)2.02042568
57Congenital primary aphakia (HP:0007707)2.01937731
58Decreased central vision (HP:0007663)2.00293313
59Genital tract atresia (HP:0001827)2.00115314
60Tented upper lip vermilion (HP:0010804)1.99926758
61Postaxial foot polydactyly (HP:0001830)1.94372226
62Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.91030326
63Abnormality of alanine metabolism (HP:0010916)1.91030326
64Hyperalaninemia (HP:0003348)1.91030326
65Sclerocornea (HP:0000647)1.90545140
66Furrowed tongue (HP:0000221)1.90402717
67Excessive salivation (HP:0003781)1.89391281
68Impaired smooth pursuit (HP:0007772)1.88879897
69Aplasia/Hypoplasia of the patella (HP:0006498)1.88123616
70Vaginal atresia (HP:0000148)1.87534094
71Male pseudohermaphroditism (HP:0000037)1.86693481
72Hypoplasia of the pons (HP:0012110)1.85905433
73Thyroiditis (HP:0100646)1.85084383
74Highly arched eyebrow (HP:0002553)1.84686880
75Abnormality of the pons (HP:0007361)1.84441212
76Poor coordination (HP:0002370)1.83176119
77Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.82983576
78Progressive inability to walk (HP:0002505)1.82307830
79Intestinal atresia (HP:0011100)1.82024451
80Dysmetric saccades (HP:0000641)1.80371484
81Anencephaly (HP:0002323)1.79921193
82Nephrogenic diabetes insipidus (HP:0009806)1.79481985
83Urinary bladder sphincter dysfunction (HP:0002839)1.79464179
84Absent rod-and cone-mediated responses on ERG (HP:0007688)1.79148453
85Hypoproteinemia (HP:0003075)1.78429377
86Hemiplegia (HP:0002301)1.77316390
87Constricted visual fields (HP:0001133)1.74084564
88Small hand (HP:0200055)1.73943051
89Ectopic kidney (HP:0000086)1.73070374
90Lissencephaly (HP:0001339)1.72693130
91Short foot (HP:0001773)1.72550868
92Hypoplastic iliac wings (HP:0002866)1.72228738
93Hypoplastic ischia (HP:0003175)1.71224331
94Birth length less than 3rd percentile (HP:0003561)1.70760611
95Cerebellar dysplasia (HP:0007033)1.70530875
96Abnormality of the ischium (HP:0003174)1.70272149
97Abnormality of ocular smooth pursuit (HP:0000617)1.69809170
98Large for gestational age (HP:0001520)1.68099987
99Absent/shortened dynein arms (HP:0200106)1.68012442
100Dynein arm defect of respiratory motile cilia (HP:0012255)1.68012442

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.52241178
2ACVR1B2.96914938
3BMPR1B2.55471505
4TAOK32.40961029
5MAPK132.35909618
6WNK32.27385786
7ADRBK22.19207363
8MAP4K21.98746858
9GRK11.87788439
10CASK1.74798791
11TXK1.74099500
12OXSR11.69588343
13MAP3K41.64110617
14ZAK1.57440918
15INSRR1.55577782
16NUAK11.53131998
17PINK11.50396595
18NTRK31.48073180
19CAMKK21.44933753
20MKNK21.41649072
21MARK11.34166465
22TNIK1.21670484
23SIK21.21171753
24TEC1.19396550
25PIK3CA1.16555078
26AKT31.16421138
27STK391.13958593
28TNK21.11829157
29DAPK21.10136843
30WNK41.08341763
31PAK31.05667999
32EPHA41.01399846
33ADRBK10.97513396
34EPHA30.94356694
35PIK3CG0.92114299
36FGFR20.91694592
37TLK10.87710451
38PKN10.86834821
39SGK20.86562260
40MAP3K70.84021741
41NTRK20.79347043
42CDK190.76708475
43STK38L0.75739379
44ITK0.73865193
45TGFBR10.73248364
46CAMK10.71480644
47BCR0.70284324
48PTK2B0.70172863
49NLK0.68168496
50TRPM70.64697858
51PRKCE0.64410369
52PLK20.63444635
53PRKCG0.63011367
54STK110.62279596
55ERBB20.61277350
56CAMK40.60937128
57ERBB30.60774824
58KIT0.60272382
59BLK0.59762197
60CAMKK10.58812180
61MKNK10.55801894
62SYK0.55691667
63FER0.55489126
64MAP2K70.55013989
65BTK0.54512336
66IRAK10.53289843
67CSNK1D0.53239060
68PRKAA20.53201540
69SGK4940.53074215
70SGK2230.53074215
71STK30.53053945
72BRSK20.52928102
73CDK30.52256765
74PNCK0.51532303
75WNK10.50065465
76TRIM280.49299490
77CAMK2A0.49189173
78CAMK1G0.48804323
79MAPK110.45134176
80ATR0.44732879
81SGK10.44554163
82CAMK1D0.41889040
83MAP4K10.41517857
84MAPKAPK50.40697150
85IKBKB0.40672310
86DYRK20.40415245
87BRD40.39246219
88PRKCH0.38663779
89PRKAA10.38657444
90DYRK1A0.37669305
91PRKCQ0.37423052
92CSNK1G20.36746740
93FES0.36179550
94PRKCZ0.35377585
95PRKACA0.35331953
96STK380.34217856
97MARK30.33549512
98LCK0.31724190
99BMPR20.31591802
100CHEK20.31484072

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.98708778
2Phototransduction_Homo sapiens_hsa047442.69295672
3Linoleic acid metabolism_Homo sapiens_hsa005912.39480886
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.36123961
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.35421833
6Butanoate metabolism_Homo sapiens_hsa006502.19415443
7Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.17172383
8Ether lipid metabolism_Homo sapiens_hsa005652.06151950
9Nitrogen metabolism_Homo sapiens_hsa009102.06105867
10Morphine addiction_Homo sapiens_hsa050321.98396064
11ABC transporters_Homo sapiens_hsa020101.97309489
12Taste transduction_Homo sapiens_hsa047421.92802480
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.90106660
14Homologous recombination_Homo sapiens_hsa034401.80871760
15Olfactory transduction_Homo sapiens_hsa047401.77662438
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.71141702
17Tryptophan metabolism_Homo sapiens_hsa003801.71091972
18Fanconi anemia pathway_Homo sapiens_hsa034601.69831416
19Glutamatergic synapse_Homo sapiens_hsa047241.63662675
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.59871396
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.55251329
22Circadian entrainment_Homo sapiens_hsa047131.53052916
23Salivary secretion_Homo sapiens_hsa049701.45620463
24GABAergic synapse_Homo sapiens_hsa047271.44317098
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41816749
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.39956098
27Insulin secretion_Homo sapiens_hsa049111.39389797
28Lysine degradation_Homo sapiens_hsa003101.39114649
29Serotonergic synapse_Homo sapiens_hsa047261.38300700
30Calcium signaling pathway_Homo sapiens_hsa040201.36579496
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.35631100
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.34883356
33Dorso-ventral axis formation_Homo sapiens_hsa043201.33010710
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.19205338
35Cholinergic synapse_Homo sapiens_hsa047251.16813161
36Glycerolipid metabolism_Homo sapiens_hsa005611.15121701
37Ovarian steroidogenesis_Homo sapiens_hsa049131.11547568
38Selenocompound metabolism_Homo sapiens_hsa004501.04332755
39Vascular smooth muscle contraction_Homo sapiens_hsa042701.03930106
40Primary immunodeficiency_Homo sapiens_hsa053401.01250463
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00258144
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.00082588
43Gastric acid secretion_Homo sapiens_hsa049710.96041862
44Oxytocin signaling pathway_Homo sapiens_hsa049210.92696610
45cAMP signaling pathway_Homo sapiens_hsa040240.92000694
46Long-term depression_Homo sapiens_hsa047300.87159962
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87135248
48Non-homologous end-joining_Homo sapiens_hsa034500.86148980
49Propanoate metabolism_Homo sapiens_hsa006400.85101542
50Basal transcription factors_Homo sapiens_hsa030220.85000985
51Dopaminergic synapse_Homo sapiens_hsa047280.84468737
52Caffeine metabolism_Homo sapiens_hsa002320.84287087
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83700329
54Histidine metabolism_Homo sapiens_hsa003400.82926226
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82726131
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81970732
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81101055
58Glycerophospholipid metabolism_Homo sapiens_hsa005640.80845193
59Retinol metabolism_Homo sapiens_hsa008300.80790745
60Aldosterone synthesis and secretion_Homo sapiens_hsa049250.79870494
61Arachidonic acid metabolism_Homo sapiens_hsa005900.79258153
62Amphetamine addiction_Homo sapiens_hsa050310.78731882
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74497968
64Regulation of autophagy_Homo sapiens_hsa041400.70285938
65Renin secretion_Homo sapiens_hsa049240.68339351
66Chemical carcinogenesis_Homo sapiens_hsa052040.67849759
67Graft-versus-host disease_Homo sapiens_hsa053320.65003492
68RNA polymerase_Homo sapiens_hsa030200.64079596
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63738795
70Circadian rhythm_Homo sapiens_hsa047100.61042839
71Fatty acid biosynthesis_Homo sapiens_hsa000610.60216063
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58546145
73Type II diabetes mellitus_Homo sapiens_hsa049300.58524412
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57737947
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57172166
76Pancreatic secretion_Homo sapiens_hsa049720.55871596
77RNA degradation_Homo sapiens_hsa030180.54432482
78Cocaine addiction_Homo sapiens_hsa050300.54314691
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.53086644
80Peroxisome_Homo sapiens_hsa041460.51394605
81beta-Alanine metabolism_Homo sapiens_hsa004100.51190660
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.46733665
83Asthma_Homo sapiens_hsa053100.46498889
84Platelet activation_Homo sapiens_hsa046110.45948687
85Ras signaling pathway_Homo sapiens_hsa040140.44976774
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43522326
87Choline metabolism in cancer_Homo sapiens_hsa052310.42759701
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41259299
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39299090
90Type I diabetes mellitus_Homo sapiens_hsa049400.38760126
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38017778
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37850917
93Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.36781428
94T cell receptor signaling pathway_Homo sapiens_hsa046600.34692448
95MAPK signaling pathway_Homo sapiens_hsa040100.33875746
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33441266
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32967088
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30771189
99Sphingolipid metabolism_Homo sapiens_hsa006000.30687745
100One carbon pool by folate_Homo sapiens_hsa006700.30602739

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