ZNF37A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1indole-containing compound catabolic process (GO:0042436)4.81266191
2indolalkylamine catabolic process (GO:0046218)4.81266191
3tryptophan catabolic process (GO:0006569)4.81266191
4indolalkylamine metabolic process (GO:0006586)4.55644773
5monoubiquitinated protein deubiquitination (GO:0035520)4.54543702
6kynurenine metabolic process (GO:0070189)4.49900726
7detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.19546628
8signal peptide processing (GO:0006465)4.14640685
9tryptophan metabolic process (GO:0006568)4.08491901
10protein K11-linked deubiquitination (GO:0035871)4.04473601
11positive regulation of developmental pigmentation (GO:0048087)4.01192934
12regulation of establishment of cell polarity (GO:2000114)3.98247883
13regulation of hippo signaling (GO:0035330)3.93287803
14neural tube formation (GO:0001841)3.83807950
15regulation of pigment cell differentiation (GO:0050932)3.82644025
16establishment of protein localization to Golgi (GO:0072600)3.66544830
17behavioral response to ethanol (GO:0048149)3.63718224
18interkinetic nuclear migration (GO:0022027)3.60536752
19cytoplasmic mRNA processing body assembly (GO:0033962)3.50658717
20detection of light stimulus involved in sensory perception (GO:0050962)3.47743983
21detection of light stimulus involved in visual perception (GO:0050908)3.47743983
22behavioral response to nicotine (GO:0035095)3.45346740
23regulation of establishment or maintenance of cell polarity (GO:0032878)3.39756722
24reflex (GO:0060004)3.39539796
25negative regulation of cytosolic calcium ion concentration (GO:0051481)3.38927287
26indole-containing compound metabolic process (GO:0042430)3.38340370
27cellular ketone body metabolic process (GO:0046950)3.36529395
28snRNA transcription (GO:0009301)3.35420125
29regulation of sarcomere organization (GO:0060297)3.33883787
30photoreceptor cell maintenance (GO:0045494)3.32369157
31fucose catabolic process (GO:0019317)3.30881908
32L-fucose metabolic process (GO:0042354)3.30881908
33L-fucose catabolic process (GO:0042355)3.30881908
34UDP-N-acetylglucosamine metabolic process (GO:0006047)3.30702720
35cilium or flagellum-dependent cell motility (GO:0001539)3.27473668
36gamma-aminobutyric acid transport (GO:0015812)3.17437988
37protein K48-linked deubiquitination (GO:0071108)3.10514209
38protein prenylation (GO:0018342)3.07805028
39prenylation (GO:0097354)3.07805028
40phospholipid translocation (GO:0045332)3.06935138
41lipid translocation (GO:0034204)3.06935138
42negative regulation of translation, ncRNA-mediated (GO:0040033)3.06700531
43regulation of translation, ncRNA-mediated (GO:0045974)3.06700531
44negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.06700531
45ketone body metabolic process (GO:1902224)3.05336407
46detection of mechanical stimulus involved in sensory perception (GO:0050974)3.02115574
47serotonin metabolic process (GO:0042428)2.99177117
48cellular response to sterol (GO:0036315)2.96019321
49tachykinin receptor signaling pathway (GO:0007217)2.88235076
50protein K63-linked deubiquitination (GO:0070536)2.87307135
51auditory receptor cell stereocilium organization (GO:0060088)2.86254113
52replication fork processing (GO:0031297)2.86053135
53thyroid hormone metabolic process (GO:0042403)2.82525630
54negative regulation of sodium ion transport (GO:0010766)2.81786573
55response to pheromone (GO:0019236)2.80381023
56primary amino compound metabolic process (GO:1901160)2.78513830
57cellular response to ethanol (GO:0071361)2.75527607
58central nervous system neuron axonogenesis (GO:0021955)2.75319687
59recombinational repair (GO:0000725)2.74330389
60double-strand break repair via homologous recombination (GO:0000724)2.73618571
61rRNA catabolic process (GO:0016075)2.73057460
62righting reflex (GO:0060013)2.72902419
63oxidative demethylation (GO:0070989)2.71273481
64benzene-containing compound metabolic process (GO:0042537)2.71185208
65negative regulation of mast cell activation (GO:0033004)2.70638151
66regulation of gene silencing by RNA (GO:0060966)2.68268321
67regulation of posttranscriptional gene silencing (GO:0060147)2.68268321
68regulation of gene silencing by miRNA (GO:0060964)2.68268321
69inner ear receptor stereocilium organization (GO:0060122)2.67069541
70cellular biogenic amine catabolic process (GO:0042402)2.66602736
71amine catabolic process (GO:0009310)2.66602736
72retinal cone cell development (GO:0046549)2.64333133
73neuronal action potential (GO:0019228)2.64288158
74epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.63958185
75protein targeting to Golgi (GO:0000042)2.63226453
76aromatic amino acid family catabolic process (GO:0009074)2.61676392
77microtubule anchoring (GO:0034453)2.57597685
78histone H3-K4 trimethylation (GO:0080182)2.57064107
79reciprocal meiotic recombination (GO:0007131)2.55477484
80reciprocal DNA recombination (GO:0035825)2.55477484
81L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.54671727
82regulation of action potential (GO:0098900)2.53579600
83proline transport (GO:0015824)2.49867358
84negative regulation of systemic arterial blood pressure (GO:0003085)2.49334290
85cilium organization (GO:0044782)2.49049112
86sex differentiation (GO:0007548)2.47932954
87cilium morphogenesis (GO:0060271)2.47918711
88retrograde transport, vesicle recycling within Golgi (GO:0000301)2.47799409
89G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.47083419
90regulation of memory T cell differentiation (GO:0043380)2.47057375
91cilium assembly (GO:0042384)2.46019785
92methionine biosynthetic process (GO:0009086)2.45351074
93NAD biosynthetic process (GO:0009435)2.44083950
94centrosome duplication (GO:0051298)2.43511834
95cAMP catabolic process (GO:0006198)2.43322704
96sulfation (GO:0051923)2.43106923
97negative regulation of keratinocyte proliferation (GO:0010839)2.41619174
98adaptation of signaling pathway (GO:0023058)2.40763809
99axoneme assembly (GO:0035082)2.40621425
100pericardium development (GO:0060039)2.40005514

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.51865209
2VDR_22108803_ChIP-Seq_LS180_Human2.87961233
3CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.83114986
4POU3F2_20337985_ChIP-ChIP_501MEL_Human2.79018498
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.78606437
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.77699670
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.77073994
8ZNF274_21170338_ChIP-Seq_K562_Hela2.69816522
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.60413909
10IGF1R_20145208_ChIP-Seq_DFB_Human2.53580139
11TAF15_26573619_Chip-Seq_HEK293_Human2.41150198
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.32560732
13FUS_26573619_Chip-Seq_HEK293_Human2.28777002
14SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.28473825
15AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.27222647
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.19601128
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.13649042
18EWS_26573619_Chip-Seq_HEK293_Human2.11284467
19P300_19829295_ChIP-Seq_ESCs_Human2.06790468
20STAT3_23295773_ChIP-Seq_U87_Human2.00756003
21ER_23166858_ChIP-Seq_MCF-7_Human1.97156858
22PIAS1_25552417_ChIP-Seq_VCAP_Human1.96965739
23SMAD4_21799915_ChIP-Seq_A2780_Human1.93267906
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89941758
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.86932145
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.76290833
27TCF4_23295773_ChIP-Seq_U87_Human1.75063662
28EZH2_22144423_ChIP-Seq_EOC_Human1.72523296
29UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.72355454
30AR_21572438_ChIP-Seq_LNCaP_Human1.71700405
31BCAT_22108803_ChIP-Seq_LS180_Human1.70184963
32MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.69817718
33NR3C1_21868756_ChIP-Seq_MCF10A_Human1.66947788
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.65722989
35CBP_20019798_ChIP-Seq_JUKART_Human1.65722989
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.64661277
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.64590081
38AR_25329375_ChIP-Seq_VCAP_Human1.57167180
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.56927679
40SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.56812949
41TP53_16413492_ChIP-PET_HCT116_Human1.56676909
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53067309
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.53067309
44EZH2_27294783_Chip-Seq_NPCs_Mouse1.49113581
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46915051
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46050828
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45435346
48TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.43985018
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.42186019
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41813786
51RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41219664
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.40902210
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.39781149
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38087758
55TCF4_22108803_ChIP-Seq_LS180_Human1.37471078
56CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.36017317
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.34051172
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.33185008
59FLI1_21867929_ChIP-Seq_TH2_Mouse1.31269702
60ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30570425
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30130784
62RUNX2_22187159_ChIP-Seq_PCA_Human1.30113095
63KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29774937
64ARNT_22903824_ChIP-Seq_MCF-7_Human1.29154123
65AHR_22903824_ChIP-Seq_MCF-7_Human1.28069595
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27657186
67EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25594502
68PRDM14_20953172_ChIP-Seq_ESCs_Human1.24622714
69CDX2_22108803_ChIP-Seq_LS180_Human1.24091969
70FOXM1_26456572_ChIP-Seq_MCF-7_Human1.23839479
71SMAD4_21741376_ChIP-Seq_EPCs_Human1.23126455
72CRX_20693478_ChIP-Seq_RETINA_Mouse1.22395517
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21768660
74EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19350074
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.19290129
76P53_22387025_ChIP-Seq_ESCs_Mouse1.17824197
77E2F1_18555785_Chip-Seq_ESCs_Mouse1.17507395
78EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17399652
79MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16752694
80SOX2_21211035_ChIP-Seq_LN229_Gbm1.16536354
81OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12219080
82KDM2B_26808549_Chip-Seq_REH_Human1.12008460
83TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10998226
84TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09494070
85CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08859288
86TP53_18474530_ChIP-ChIP_U2OS_Human1.08741405
87SOX2_19829295_ChIP-Seq_ESCs_Human1.07500734
88NANOG_19829295_ChIP-Seq_ESCs_Human1.07500734
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07187959
90CMYC_18555785_Chip-Seq_ESCs_Mouse1.07161034
91SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07116902
92BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05903824
93NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05732488
94NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05732488
95SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05142674
96STAT3_18555785_Chip-Seq_ESCs_Mouse1.05039715
97IRF1_19129219_ChIP-ChIP_H3396_Human1.04975052
98P300_18555785_Chip-Seq_ESCs_Mouse1.04028246
99CBX2_27304074_Chip-Seq_ESCs_Mouse1.02610056
100TBL1_22424771_ChIP-Seq_293T_Human1.01743006

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.34317063
2MP0008057_abnormal_DNA_replication3.88724327
3MP0003195_calcinosis3.80074974
4MP0005551_abnormal_eye_electrophysiolog2.56014648
5MP0009046_muscle_twitch2.37421579
6MP0000427_abnormal_hair_cycle2.35365293
7MP0001501_abnormal_sleep_pattern2.14933955
8MP0000383_abnormal_hair_follicle2.11796728
9MP0005174_abnormal_tail_pigmentation2.09699780
10MP0001968_abnormal_touch/_nociception2.08561894
11MP0003950_abnormal_plasma_membrane2.02733359
12MP0008877_abnormal_DNA_methylation2.02281964
13MP0003646_muscle_fatigue1.89547965
14MP0005253_abnormal_eye_physiology1.87231978
15MP0005646_abnormal_pituitary_gland1.86777972
16MP0004043_abnormal_pH_regulation1.83885226
17MP0009745_abnormal_behavioral_response1.79164378
18MP0000372_irregular_coat_pigmentation1.66941942
19MP0002938_white_spotting1.62525272
20MP0003045_fibrosis1.60070197
21MP0002736_abnormal_nociception_after1.59705338
22MP0001986_abnormal_taste_sensitivity1.58377629
23MP0002876_abnormal_thyroid_physiology1.57282751
24MP0002102_abnormal_ear_morphology1.57114823
25MP0005645_abnormal_hypothalamus_physiol1.56793919
26MP0006072_abnormal_retinal_apoptosis1.46257629
27MP0003252_abnormal_bile_duct1.44764260
28MP0001486_abnormal_startle_reflex1.44297123
29MP0002837_dystrophic_cardiac_calcinosis1.43851322
30MP0000371_diluted_coat_color1.43193481
31MP0003787_abnormal_imprinting1.39840397
32MP0002638_abnormal_pupillary_reflex1.36453358
33MP0010386_abnormal_urinary_bladder1.35811484
34MP0002272_abnormal_nervous_system1.34650085
35MP0004924_abnormal_behavior1.33504357
36MP0005386_behavior/neurological_phenoty1.33504357
37MP0003136_yellow_coat_color1.32441510
38MP0003890_abnormal_embryonic-extraembry1.31632120
39MP0010678_abnormal_skin_adnexa1.31611466
40MP0002064_seizures1.31514345
41MP0003880_abnormal_central_pattern1.30751158
42MP0002168_other_aberrant_phenotype1.30036142
43MP0000631_abnormal_neuroendocrine_gland1.28700767
44MP0000015_abnormal_ear_pigmentation1.28321413
45MP0005171_absent_coat_pigmentation1.28320574
46MP0004215_abnormal_myocardial_fiber1.24522839
47MP0001485_abnormal_pinna_reflex1.22273199
48MP0002095_abnormal_skin_pigmentation1.20522829
49MP0006276_abnormal_autonomic_nervous1.19818431
50MP0002928_abnormal_bile_duct1.18905492
51MP0004145_abnormal_muscle_electrophysio1.18076978
52MP0003718_maternal_effect1.18024760
53MP0004142_abnormal_muscle_tone1.16881990
54MP0002572_abnormal_emotion/affect_behav1.15503577
55MP0009697_abnormal_copulation1.13598665
56MP0008872_abnormal_physiological_respon1.12172745
57MP0004147_increased_porphyrin_level1.12036145
58MP0009780_abnormal_chondrocyte_physiolo1.11545755
59MP0005310_abnormal_salivary_gland1.10272471
60MP0005395_other_phenotype1.09345057
61MP0002735_abnormal_chemical_nociception1.08668051
62MP0001984_abnormal_olfaction1.06113189
63MP0003635_abnormal_synaptic_transmissio1.03961860
64MP0002067_abnormal_sensory_capabilities1.03856738
65MP0008961_abnormal_basal_metabolism1.03365738
66MP0006054_spinal_hemorrhage1.01660421
67MP0010094_abnormal_chromosome_stability1.01660082
68MP0002557_abnormal_social/conspecific_i1.00648196
69MP0003943_abnormal_hepatobiliary_system0.96699652
70MP0002234_abnormal_pharynx_morphology0.96567758
71MP0005075_abnormal_melanosome_morpholog0.96430832
72MP0005187_abnormal_penis_morphology0.96364713
73MP0008058_abnormal_DNA_repair0.94023766
74MP0002138_abnormal_hepatobiliary_system0.93614758
75MP0003633_abnormal_nervous_system0.90378854
76MP0005647_abnormal_sex_gland0.90237234
77MP0003937_abnormal_limbs/digits/tail_de0.89568099
78MP0004130_abnormal_muscle_cell0.88097289
79MP0006292_abnormal_olfactory_placode0.87831832
80MP0000647_abnormal_sebaceous_gland0.87286201
81MP0002063_abnormal_learning/memory/cond0.87193098
82MP0004742_abnormal_vestibular_system0.86470991
83MP0000538_abnormal_urinary_bladder0.85676428
84MP0005195_abnormal_posterior_eye0.85200480
85MP0001970_abnormal_pain_threshold0.84783410
86MP0005085_abnormal_gallbladder_physiolo0.84117363
87MP0003121_genomic_imprinting0.83100018
88MP0002229_neurodegeneration0.81636338
89MP0003868_abnormal_feces_composition0.81410286
90MP0002009_preneoplasia0.81332962
91MP0004885_abnormal_endolymph0.79774409
92MP0004134_abnormal_chest_morphology0.76778627
93MP0002751_abnormal_autonomic_nervous0.74955705
94MP0002160_abnormal_reproductive_system0.74027246
95MP0000230_abnormal_systemic_arterial0.73689721
96MP0002075_abnormal_coat/hair_pigmentati0.73025757
97MP0001324_abnormal_eye_pigmentation0.71978927
98MP0005220_abnormal_exocrine_pancreas0.71694505
99MP0005266_abnormal_metabolism0.71628368
100MP0002734_abnormal_mechanical_nocicepti0.71457166

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)4.96231187
2Gaze-evoked nystagmus (HP:0000640)4.52507972
3Genetic anticipation (HP:0003743)4.37452100
4Pancreatic cysts (HP:0001737)4.33668981
5Progressive cerebellar ataxia (HP:0002073)3.88240478
6Pancreatic fibrosis (HP:0100732)3.81942884
7True hermaphroditism (HP:0010459)3.62905112
8Attenuation of retinal blood vessels (HP:0007843)3.59106897
9Abnormality of the renal cortex (HP:0011035)3.44203966
10Abnormality of midbrain morphology (HP:0002418)3.44181237
11Molar tooth sign on MRI (HP:0002419)3.44181237
12Fair hair (HP:0002286)3.21021431
13Protruding tongue (HP:0010808)3.18537450
14Chronic hepatic failure (HP:0100626)3.12761384
15Nephronophthisis (HP:0000090)3.08123192
16Febrile seizures (HP:0002373)3.02190680
17Absent speech (HP:0001344)2.99854252
18Abnormality of the renal medulla (HP:0100957)2.95781532
19Congenital stationary night blindness (HP:0007642)2.94273916
20Cystic liver disease (HP:0006706)2.85631655
21Clumsiness (HP:0002312)2.81002787
22Volvulus (HP:0002580)2.80429491
23Dialeptic seizures (HP:0011146)2.67340003
24Renal cortical cysts (HP:0000803)2.66348887
25Focal seizures (HP:0007359)2.65241718
26Aplasia/Hypoplasia of the tibia (HP:0005772)2.62200766
27Congenital sensorineural hearing impairment (HP:0008527)2.61802131
28Abnormality of macular pigmentation (HP:0008002)2.61127574
29Type II lissencephaly (HP:0007260)2.60885885
30Medial flaring of the eyebrow (HP:0010747)2.57652426
31Absence seizures (HP:0002121)2.56442307
32Broad-based gait (HP:0002136)2.54157253
33Generalized hypopigmentation of hair (HP:0011358)2.52178636
34Bony spicule pigmentary retinopathy (HP:0007737)2.51604239
35Widely spaced teeth (HP:0000687)2.50539186
36Cerebellar dysplasia (HP:0007033)2.45764017
37Increased corneal curvature (HP:0100692)2.45403380
38Keratoconus (HP:0000563)2.45403380
39Tubular atrophy (HP:0000092)2.41153212
40Progressive inability to walk (HP:0002505)2.38637622
41Abolished electroretinogram (ERG) (HP:0000550)2.32106839
42Aplasia/Hypoplasia of the tongue (HP:0010295)2.27714910
43Furrowed tongue (HP:0000221)2.26581536
44Inability to walk (HP:0002540)2.26339157
45Small hand (HP:0200055)2.25328419
46Focal motor seizures (HP:0011153)2.22944925
47Dysmetric saccades (HP:0000641)2.22573966
48Hypothermia (HP:0002045)2.13226559
49Chromsome breakage (HP:0040012)2.11251997
50Large for gestational age (HP:0001520)2.09377963
51Polydipsia (HP:0001959)2.06713274
52Abnormal drinking behavior (HP:0030082)2.06713274
53Congenital hepatic fibrosis (HP:0002612)2.06398774
54Abnormality of alanine metabolism (HP:0010916)2.05866622
55Hyperalaninemia (HP:0003348)2.05866622
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.05866622
57Stomach cancer (HP:0012126)2.04553468
58Constricted visual fields (HP:0001133)2.04536169
59Hypoplastic labia majora (HP:0000059)2.03788269
60Patellar aplasia (HP:0006443)2.02095806
61Hypoplastic ischia (HP:0003175)2.02003785
62Aplasia/Hypoplasia of the uvula (HP:0010293)2.01763418
63Postaxial foot polydactyly (HP:0001830)2.01346180
64Abnormality of the ischium (HP:0003174)2.00802075
65Gait imbalance (HP:0002141)2.00474947
66Hypoplasia of the pons (HP:0012110)1.99642128
67Congenital primary aphakia (HP:0007707)1.98407728
68Central scotoma (HP:0000603)1.96281129
69Abnormality of the pons (HP:0007361)1.96159250
70Highly arched eyebrow (HP:0002553)1.95394627
71Sclerocornea (HP:0000647)1.90863451
72Hemiparesis (HP:0001269)1.89877664
73Pendular nystagmus (HP:0012043)1.89855538
74Abnormality of the labia majora (HP:0012881)1.89322668
75Atonic seizures (HP:0010819)1.88234717
76Abnormality of chromosome stability (HP:0003220)1.87946537
77Astigmatism (HP:0000483)1.86917411
78Chromosomal breakage induced by crosslinking agents (HP:0003221)1.86194937
79Short foot (HP:0001773)1.86148639
80Preaxial foot polydactyly (HP:0001841)1.85554024
81Decreased circulating renin level (HP:0003351)1.84061009
82Genital tract atresia (HP:0001827)1.83422508
83Thyroiditis (HP:0100646)1.82993706
84Aplasia/Hypoplasia of the patella (HP:0006498)1.81385894
85Sloping forehead (HP:0000340)1.80670025
86Intestinal atresia (HP:0011100)1.80531419
87Bile duct proliferation (HP:0001408)1.80377171
88Abnormal biliary tract physiology (HP:0012439)1.80377171
89Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.80317363
90Prostate neoplasm (HP:0100787)1.80259349
91Drooling (HP:0002307)1.80191749
92Birth length less than 3rd percentile (HP:0003561)1.80175723
93Oligodactyly (hands) (HP:0001180)1.80137628
94Clubbing of toes (HP:0100760)1.79908312
95Tented upper lip vermilion (HP:0010804)1.79244707
96Facial diplegia (HP:0001349)1.78875478
97Poor coordination (HP:0002370)1.76240112
98Anencephaly (HP:0002323)1.75883064
99Chorioretinal atrophy (HP:0000533)1.74877487
100Decreased central vision (HP:0007663)1.74199781

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK9.70959958
2BMPR1B3.44240973
3ACVR1B3.33426880
4ADRBK22.10235804
5MKNK22.04575138
6CASK2.02208091
7INSRR1.85657182
8NUAK11.80220482
9STK38L1.75879012
10MAPK131.75849609
11WNK31.68053573
12GRK11.65690349
13OXSR11.65622993
14MAP4K21.59272608
15AKT31.58874289
16NTRK31.49513849
17TAOK31.40447701
18ZAK1.39628268
19STK391.34335898
20MAP3K41.26530484
21PINK11.26414598
22TGFBR11.20914653
23BRSK21.16005448
24PAK31.08812813
25TNIK1.08725969
26PNCK1.05913186
27LATS11.03666107
28TEC1.03419823
29ADRBK11.01196951
30STK31.00180275
31MKNK10.98299628
32FGFR20.97456874
33KIT0.90232734
34PRKCE0.85750881
35PIK3CG0.85326817
36DAPK20.85322213
37TRPM70.82753513
38FER0.81294356
39BRD40.81092400
40CAMKK20.80902505
41WNK40.79199400
42NLK0.79140111
43PIK3CA0.76777922
44PTK2B0.76740232
45MELK0.75416040
46SGK20.73949424
47WEE10.73339523
48STK380.73299527
49PRKAA20.71785038
50CAMK1G0.69320519
51MAP3K70.68294196
52EIF2AK30.67703331
53PRKCG0.65548809
54TXK0.65235753
55PLK20.63485262
56MARK10.60844997
57PRKAA10.56467668
58ERBB30.55514893
59CSNK1D0.54819890
60CAMK1D0.54613995
61TNK20.53352135
62ATM0.52988164
63BCR0.51637731
64EPHA40.51204905
65MAPKAPK50.50915575
66STK110.48953081
67IRAK10.48858539
68CAMK2A0.48649049
69CHEK20.48003400
70PKN10.47892685
71TLK10.45542338
72ATR0.43764270
73CDK30.43693133
74OBSCN0.42361594
75CSNK1A1L0.42013369
76EPHA30.41311273
77MAP2K60.41306042
78WNK10.40443558
79CSNK1G10.39789459
80CDK120.38714576
81MUSK0.38547325
82MAPKAPK30.38507627
83SGK10.38498754
84CCNB10.38023496
85NEK20.37623689
86PRKACB0.36178155
87ERBB20.35261040
88MST40.35073471
89EIF2AK20.34776070
90IKBKB0.33566162
91CHUK0.32705109
92CAMK10.32425126
93PRKG10.32365227
94CSNK1G20.32205811
95PRKACA0.31990607
96CAMK40.31628702
97MAPK110.31600687
98PLK30.28521341
99CSNK1A10.28346309
100PRKCB0.27836202

Predicted pathways (KEGG)

RankGene SetZ-score
1Butanoate metabolism_Homo sapiens_hsa006502.61509218
2Phototransduction_Homo sapiens_hsa047442.44142201
3Nicotine addiction_Homo sapiens_hsa050332.30112518
4ABC transporters_Homo sapiens_hsa020102.28695413
5Tryptophan metabolism_Homo sapiens_hsa003802.26939692
6Homologous recombination_Homo sapiens_hsa034402.22195393
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.16950782
8Nitrogen metabolism_Homo sapiens_hsa009102.16629591
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.09572068
10Fanconi anemia pathway_Homo sapiens_hsa034601.93082622
11Linoleic acid metabolism_Homo sapiens_hsa005911.92343904
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.92193468
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.91425026
14Selenocompound metabolism_Homo sapiens_hsa004501.91231908
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.82010098
16Non-homologous end-joining_Homo sapiens_hsa034501.80133154
17Taste transduction_Homo sapiens_hsa047421.76366852
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.73674347
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70267932
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.68303663
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.64016685
22Propanoate metabolism_Homo sapiens_hsa006401.59309654
23Olfactory transduction_Homo sapiens_hsa047401.58472728
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57927194
25Lysine degradation_Homo sapiens_hsa003101.55949324
26Morphine addiction_Homo sapiens_hsa050321.52267517
27Ether lipid metabolism_Homo sapiens_hsa005651.51253976
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.46849939
29Dorso-ventral axis formation_Homo sapiens_hsa043201.45115135
30Glutamatergic synapse_Homo sapiens_hsa047241.42784191
31Circadian entrainment_Homo sapiens_hsa047131.34148280
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.34123273
33Circadian rhythm_Homo sapiens_hsa047101.32351670
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.30443832
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28786184
36Salivary secretion_Homo sapiens_hsa049701.24616568
37Insulin secretion_Homo sapiens_hsa049111.23802371
38Histidine metabolism_Homo sapiens_hsa003401.23406026
39Glycerolipid metabolism_Homo sapiens_hsa005611.20871685
40Retinol metabolism_Homo sapiens_hsa008301.19928965
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.19335440
42Calcium signaling pathway_Homo sapiens_hsa040201.19070191
43Serotonergic synapse_Homo sapiens_hsa047261.15688548
44GABAergic synapse_Homo sapiens_hsa047271.14968420
45Basal transcription factors_Homo sapiens_hsa030221.08285855
46Fatty acid biosynthesis_Homo sapiens_hsa000611.05845579
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02677010
48Vascular smooth muscle contraction_Homo sapiens_hsa042701.01647844
49RNA polymerase_Homo sapiens_hsa030200.99308318
50Chemical carcinogenesis_Homo sapiens_hsa052040.98464606
51Ovarian steroidogenesis_Homo sapiens_hsa049130.97206511
52beta-Alanine metabolism_Homo sapiens_hsa004100.95039778
53Caffeine metabolism_Homo sapiens_hsa002320.90361383
54One carbon pool by folate_Homo sapiens_hsa006700.89832699
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87581688
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83764000
57Long-term depression_Homo sapiens_hsa047300.82156978
58Dopaminergic synapse_Homo sapiens_hsa047280.78651785
59Renin secretion_Homo sapiens_hsa049240.76375932
60Cholinergic synapse_Homo sapiens_hsa047250.74164535
61Gastric acid secretion_Homo sapiens_hsa049710.73582511
62cAMP signaling pathway_Homo sapiens_hsa040240.73193982
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72191482
64Oxytocin signaling pathway_Homo sapiens_hsa049210.71986985
65Fatty acid degradation_Homo sapiens_hsa000710.71958125
66Sphingolipid metabolism_Homo sapiens_hsa006000.71616332
67Amphetamine addiction_Homo sapiens_hsa050310.70880129
68Peroxisome_Homo sapiens_hsa041460.64861288
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63265342
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62932688
71Cocaine addiction_Homo sapiens_hsa050300.62482178
72RNA degradation_Homo sapiens_hsa030180.62306620
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61468343
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55792277
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55430416
76Protein export_Homo sapiens_hsa030600.55376798
77Pancreatic secretion_Homo sapiens_hsa049720.51544317
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.51020183
79Type II diabetes mellitus_Homo sapiens_hsa049300.50177329
80Arachidonic acid metabolism_Homo sapiens_hsa005900.48777384
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48767840
82Fatty acid metabolism_Homo sapiens_hsa012120.47865744
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46641395
84TGF-beta signaling pathway_Homo sapiens_hsa043500.46303653
85Regulation of autophagy_Homo sapiens_hsa041400.45878470
86Purine metabolism_Homo sapiens_hsa002300.44351452
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43850289
88Melanoma_Homo sapiens_hsa052180.38801035
89Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.38592060
90Mineral absorption_Homo sapiens_hsa049780.37415230
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36109631
92FoxO signaling pathway_Homo sapiens_hsa040680.33531042
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32305831
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32290732
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.31446190
96Thyroid hormone synthesis_Homo sapiens_hsa049180.29018082
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.28867243
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.27297010
99Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.25644974
100Bile secretion_Homo sapiens_hsa049760.23505709

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