ZNF358

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)5.07112307
2glutamate secretion (GO:0014047)4.14696935
3positive regulation of synapse maturation (GO:0090129)3.76888835
4synaptic vesicle maturation (GO:0016188)3.75805649
5sodium ion export (GO:0071436)3.74052708
6cellular potassium ion homeostasis (GO:0030007)3.72914904
7synaptic vesicle exocytosis (GO:0016079)3.70486674
8locomotory exploration behavior (GO:0035641)3.52429506
9regulation of short-term neuronal synaptic plasticity (GO:0048172)3.38609443
10regulation of synaptic vesicle exocytosis (GO:2000300)3.37524267
11membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.35858193
12cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.29273683
13regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.28515148
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.28382102
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.18684413
16neuronal ion channel clustering (GO:0045161)3.17140898
17cell communication by electrical coupling (GO:0010644)3.15627624
18creatine metabolic process (GO:0006600)3.15209457
19positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.12288162
20cerebellar granule cell differentiation (GO:0021707)3.09675943
21regulation of synapse maturation (GO:0090128)3.09130273
22postsynaptic membrane organization (GO:0001941)3.08024689
23dendritic spine morphogenesis (GO:0060997)3.06638025
24cell migration in hindbrain (GO:0021535)3.01234159
25cytoskeletal anchoring at plasma membrane (GO:0007016)3.00108509
26regulation of synapse structural plasticity (GO:0051823)2.95106691
27negative regulation of catenin import into nucleus (GO:0035414)2.92481418
28positive regulation of dendritic spine development (GO:0060999)2.89179765
29protein retention in ER lumen (GO:0006621)2.87881356
30regulation of neuronal synaptic plasticity (GO:0048168)2.86738945
31neuromuscular process controlling balance (GO:0050885)2.84696573
32regulation of synaptic vesicle transport (GO:1902803)2.82982805
33planar cell polarity pathway involved in neural tube closure (GO:0090179)2.82909606
34cell-cell junction maintenance (GO:0045217)2.79378203
35dendritic spine organization (GO:0097061)2.78971983
36cardiac myofibril assembly (GO:0055003)2.75996825
37central nervous system myelination (GO:0022010)2.74033441
38axon ensheathment in central nervous system (GO:0032291)2.74033441
39cerebellar Purkinje cell layer development (GO:0021680)2.72212397
40vocalization behavior (GO:0071625)2.69967775
41regulation of early endosome to late endosome transport (GO:2000641)2.68774022
42sarcoplasmic reticulum calcium ion transport (GO:0070296)2.66392885
43actin-myosin filament sliding (GO:0033275)2.64962437
44muscle filament sliding (GO:0030049)2.64962437
45neurotransmitter secretion (GO:0007269)2.63820687
46exploration behavior (GO:0035640)2.62299187
47positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.62096059
48cardiac muscle contraction (GO:0060048)2.59075471
49regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.56601825
50regulation of glutamate receptor signaling pathway (GO:1900449)2.54062878
51synaptic vesicle endocytosis (GO:0048488)2.53413995
52layer formation in cerebral cortex (GO:0021819)2.53340574
53activation of protein kinase A activity (GO:0034199)2.52086514
54myofibril assembly (GO:0030239)2.51257214
55potassium ion homeostasis (GO:0055075)2.50164026
56adherens junction assembly (GO:0034333)2.49346847
57dopamine receptor signaling pathway (GO:0007212)2.48777052
58neuronal action potential propagation (GO:0019227)2.47666949
59maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.44528091
60potassium ion import (GO:0010107)2.43951774
61regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.43504543
62protein targeting to plasma membrane (GO:0072661)2.42247583
63regulation of voltage-gated calcium channel activity (GO:1901385)2.42003483
64peripheral nervous system axon ensheathment (GO:0032292)2.41969035
65myelination in peripheral nervous system (GO:0022011)2.41969035
66positive regulation of dendrite development (GO:1900006)2.40132845
67negative regulation of cell size (GO:0045792)2.36490584
68establishment of mitochondrion localization (GO:0051654)2.36383609
69regulation of long-term neuronal synaptic plasticity (GO:0048169)2.36039852
70regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.35617936
71axon extension (GO:0048675)2.33962550
72amino acid import (GO:0043090)2.33320106
73cellular response to monoamine stimulus (GO:0071868)2.32992624
74cellular response to catecholamine stimulus (GO:0071870)2.32992624
75tooth mineralization (GO:0034505)2.32910657
76G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.32217487
77response to parathyroid hormone (GO:0071107)2.30942406
78respiratory system process (GO:0003016)2.30291080
79mitochondrion transport along microtubule (GO:0047497)2.29532335
80establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.29532335
81cochlea morphogenesis (GO:0090103)2.29474339
82regulation of synaptic plasticity (GO:0048167)2.29303423
83skeletal muscle fiber development (GO:0048741)2.28578954
84barbed-end actin filament capping (GO:0051016)2.28280357
85L-amino acid import (GO:0043092)2.27426455
86semaphorin-plexin signaling pathway (GO:0071526)2.26102171
87striated muscle contraction (GO:0006941)2.25551061
88regulation of ARF protein signal transduction (GO:0032012)2.25372286
89positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.25282172
90protein heterotrimerization (GO:0070208)2.25073907
91neurotransmitter-gated ion channel clustering (GO:0072578)2.22939693
92regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.22124001
93cellular sodium ion homeostasis (GO:0006883)2.21003753
94NADH metabolic process (GO:0006734)2.20671720
95endothelial cell chemotaxis (GO:0035767)2.18377443
96regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.18374075
97adhesion of symbiont to host cell (GO:0044650)2.18310357
98virion attachment to host cell (GO:0019062)2.18310357
99focal adhesion assembly (GO:0048041)2.17710280
100cell-substrate adherens junction assembly (GO:0007045)2.17710280

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.52401606
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.90658940
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.87547181
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.80529307
5LXR_22292898_ChIP-Seq_THP-1_Human2.77945698
6EZH2_22144423_ChIP-Seq_EOC_Human2.70687866
7ERG_21242973_ChIP-ChIP_JURKAT_Human2.52604047
8MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.30155589
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.29745526
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.29745526
11ZFP281_18757296_ChIP-ChIP_E14_Mouse2.28183510
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.25245529
13KDM2B_26808549_Chip-Seq_K562_Human2.24089363
14KDM2B_26808549_Chip-Seq_SUP-B15_Human2.16705485
15EZH2_27294783_Chip-Seq_ESCs_Mouse2.10744508
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.09228321
17SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08680539
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.05892101
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.00228506
20TRIM28_21343339_ChIP-Seq_HEK293_Human1.99930858
21JARID2_20064375_ChIP-Seq_MESCs_Mouse1.99304874
22RNF2_27304074_Chip-Seq_ESCs_Mouse1.97672648
23CTCF_27219007_Chip-Seq_Bcells_Human1.97094395
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.95135123
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.94674709
26DNAJC2_21179169_ChIP-ChIP_NT2_Human1.94326174
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.93767469
28SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.93044095
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.90487861
30* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.90285711
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.89039773
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88705193
33SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.87612379
34DROSHA_22980978_ChIP-Seq_HELA_Human1.86633854
35WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.83684355
36RARB_27405468_Chip-Seq_BRAIN_Mouse1.82092830
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.79599341
38RACK7_27058665_Chip-Seq_MCF-7_Human1.78653025
39ELK3_25401928_ChIP-Seq_HUVEC_Human1.77571813
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.72049357
41TP53_20018659_ChIP-ChIP_R1E_Mouse1.69179413
42SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.67776530
43TET1_21451524_ChIP-Seq_MESCs_Mouse1.67156417
44KDM2B_26808549_Chip-Seq_DND41_Human1.66866222
45UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.64965063
46TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.64100051
47PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.59924842
48P68_20966046_ChIP-Seq_HELA_Human1.57870394
49ZFP281_27345836_Chip-Seq_ESCs_Mouse1.57741508
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56637450
51SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.55004475
52SRY_22984422_ChIP-ChIP_TESTIS_Rat1.48959187
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.46788242
54SMC4_20622854_ChIP-Seq_HELA_Human1.46693065
55SA1_27219007_Chip-Seq_ERYTHROID_Human1.45624464
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44267774
57CREB1_26743006_Chip-Seq_LNCaP_Human1.42976549
58EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.42102507
59CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.41386943
60OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.41246063
61RING1B_27294783_Chip-Seq_ESCs_Mouse1.40976115
62SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.37074921
63ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.36908945
64TET1_21490601_ChIP-Seq_MESCs_Mouse1.35951170
65RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.35171354
66CTCF_27219007_Chip-Seq_ERYTHROID_Human1.34858422
67CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.33354380
68NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.32572683
69CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.31492783
70KDM2B_26808549_Chip-Seq_JURKAT_Human1.26288745
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.23366200
72VDR_21846776_ChIP-Seq_THP-1_Human1.22719587
73TP63_17297297_ChIP-ChIP_HaCaT_Human1.22682432
74RING1B_27294783_Chip-Seq_NPCs_Mouse1.21570101
75SMC3_22415368_ChIP-Seq_MEFs_Mouse1.21146189
76MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.20710676
77RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.18267622
78REST_18959480_ChIP-ChIP_MESCs_Mouse1.17645004
79ZNF263_19887448_ChIP-Seq_K562_Human1.16094883
80STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.14162542
81CLOCK_20551151_ChIP-Seq_293T_Human1.13494844
82TCF7_22412390_ChIP-Seq_EML_Mouse1.12963201
83ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.12872678
84PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.12835615
85STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12485857
86REST_21632747_ChIP-Seq_MESCs_Mouse1.12101693
87SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.11245340
88P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08484162
89SMC1_22415368_ChIP-Seq_MEFs_Mouse1.07948942
90SA1_27219007_Chip-Seq_Bcells_Human1.06435729
91NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03714354
92TP53_23651856_ChIP-Seq_MEFs_Mouse1.02577780
93TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01341219
94RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99031826
95TBX20_22328084_ChIP-Seq_HEART_Mouse0.97940921
96TBX20_22080862_ChIP-Seq_HEART_Mouse0.97940921
97TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97806356
98OCT4_19829295_ChIP-Seq_ESCs_Human0.97078155
99ELF1_20517297_ChIP-Seq_JURKAT_Human0.96816614
100MYC_27129775_Chip-Seq_CORNEA_Mouse0.96648697

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.23149247
2MP0000751_myopathy3.43282494
3MP0003705_abnormal_hypodermis_morpholog3.09561722
4MP0004270_analgesia2.76378984
5MP0004858_abnormal_nervous_system2.32650608
6MP0005670_abnormal_white_adipose2.17552160
7MP0002249_abnormal_larynx_morphology2.16931598
8MP0003635_abnormal_synaptic_transmissio2.16908991
9MP0008438_abnormal_cutaneous_collagen2.13958883
10MP0003283_abnormal_digestive_organ2.12746452
11MP0004145_abnormal_muscle_electrophysio2.05855978
12MP0005423_abnormal_somatic_nervous2.01696070
13MP0003329_amyloid_beta_deposits1.99118942
14MP0003880_abnormal_central_pattern1.99073355
15MP0003879_abnormal_hair_cell1.97935980
16MP0003279_aneurysm1.85823878
17MP0010030_abnormal_orbit_morphology1.82067617
18MP0009780_abnormal_chondrocyte_physiolo1.79805324
19MP0004130_abnormal_muscle_cell1.76894448
20MP0002064_seizures1.76198012
21MP0000749_muscle_degeneration1.75519213
22MP0002063_abnormal_learning/memory/cond1.75386547
23MP0005623_abnormal_meninges_morphology1.71725127
24MP0000747_muscle_weakness1.61594645
25MP0009379_abnormal_foot_pigmentation1.61400287
26MP0000759_abnormal_skeletal_muscle1.60767657
27MP0002734_abnormal_mechanical_nocicepti1.54653142
28MP0005409_darkened_coat_color1.54022497
29MP0008569_lethality_at_weaning1.53536190
30MP0003123_paternal_imprinting1.47957981
31MP0005503_abnormal_tendon_morphology1.46938507
32MP0002822_catalepsy1.46581312
33MP0004087_abnormal_muscle_fiber1.44078623
34MP0001958_emphysema1.43720608
35MP0010368_abnormal_lymphatic_system1.33107831
36MP0002572_abnormal_emotion/affect_behav1.31421168
37MP0000003_abnormal_adipose_tissue1.30793772
38MP0009745_abnormal_behavioral_response1.29661231
39MP0000733_abnormal_muscle_development1.27596901
40MP0000778_abnormal_nervous_system1.27566878
41MP0005257_abnormal_intraocular_pressure1.27163390
42MP0000678_abnormal_parathyroid_gland1.25608377
43MP0003634_abnormal_glial_cell1.25158035
44MP0000750_abnormal_muscle_regeneration1.24914073
45MP0002272_abnormal_nervous_system1.24335579
46MP0001486_abnormal_startle_reflex1.23537203
47MP0005375_adipose_tissue_phenotype1.23392191
48MP0005666_abnormal_adipose_tissue1.22809945
49MP0004036_abnormal_muscle_relaxation1.21801286
50MP0001502_abnormal_circadian_rhythm1.21161298
51MP0002106_abnormal_muscle_physiology1.20172204
52MP0005058_abnormal_lysosome_morphology1.17390421
53MP0000566_synostosis1.14621878
54MP0000013_abnormal_adipose_tissue1.14113697
55MP0002108_abnormal_muscle_morphology1.13329430
56MP0005369_muscle_phenotype1.13007997
57MP0004510_myositis1.12635984
58MP0006138_congestive_heart_failure1.12418998
59MP0001849_ear_inflammation1.11772655
60MP0004272_abnormal_basement_membrane1.10464157
61MP0002089_abnormal_postnatal_growth/wei1.08954808
62MP0000049_abnormal_middle_ear1.08807067
63MP0002733_abnormal_thermal_nociception1.08734387
64MP0001970_abnormal_pain_threshold1.07478902
65MP0000534_abnormal_ureter_morphology1.05976641
66MP0001348_abnormal_lacrimal_gland1.04990782
67MP0005620_abnormal_muscle_contractility1.04561811
68MP0000955_abnormal_spinal_cord1.03935953
69MP0003646_muscle_fatigue1.03793631
70MP0005330_cardiomyopathy1.03199153
71MP0005508_abnormal_skeleton_morphology1.01304148
72MP0003690_abnormal_glial_cell1.00936262
73MP0003137_abnormal_impulse_conducting1.00897657
74MP0001440_abnormal_grooming_behavior0.98367729
75MP0001299_abnormal_eye_distance/0.97936770
76MP0004811_abnormal_neuron_physiology0.94639367
77MP0009250_abnormal_appendicular_skeleto0.93253015
78MP0004233_abnormal_muscle_weight0.93123067
79MP0000462_abnormal_digestive_system0.92806366
80MP0002066_abnormal_motor_capabilities/c0.92420955
81MP0004185_abnormal_adipocyte_glucose0.92414692
82MP0000681_abnormal_thyroid_gland0.92382800
83MP0000920_abnormal_myelination0.91339870
84MP0001346_abnormal_lacrimal_gland0.91047073
85MP0002882_abnormal_neuron_morphology0.87827530
86MP0003075_altered_response_to0.87582340
87MP0002896_abnormal_bone_mineralization0.87435619
88MP0002557_abnormal_social/conspecific_i0.87417162
89MP0003942_abnormal_urinary_system0.85816060
90MP0004885_abnormal_endolymph0.85042192
91MP0005451_abnormal_body_composition0.82517384
92MP0009840_abnormal_foam_cell0.81400299
93MP0002269_muscular_atrophy0.81060247
94MP0006276_abnormal_autonomic_nervous0.80352360
95MP0003633_abnormal_nervous_system0.79549680
96MP0009384_cardiac_valve_regurgitation0.79537949
97MP0010630_abnormal_cardiac_muscle0.79465120
98MP0005167_abnormal_blood-brain_barrier0.78201696
99MP0002932_abnormal_joint_morphology0.77760211
100MP0005595_abnormal_vascular_smooth0.77573491

Predicted human phenotypes

RankGene SetZ-score
1Type 1 muscle fiber predominance (HP:0003803)4.49939143
2Protrusio acetabuli (HP:0003179)3.80900468
3Obstructive sleep apnea (HP:0002870)3.61854301
4Myokymia (HP:0002411)3.56405597
5Increased variability in muscle fiber diameter (HP:0003557)3.35612967
6Exercise-induced myalgia (HP:0003738)3.33097247
7Muscle fiber inclusion bodies (HP:0100299)3.30262931
8Myopathic facies (HP:0002058)3.29191793
9Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.20435954
10Nemaline bodies (HP:0003798)3.19077535
11Abnormality of skeletal muscle fiber size (HP:0012084)3.10793290
12Shallow orbits (HP:0000586)2.96425317
13Round ear (HP:0100830)2.91416353
14Turricephaly (HP:0000262)2.85281043
15Distal lower limb muscle weakness (HP:0009053)2.79805093
16Spinal rigidity (HP:0003306)2.79724645
17Increased connective tissue (HP:0009025)2.79668246
18Centrally nucleated skeletal muscle fibers (HP:0003687)2.74674446
19Neurofibrillary tangles (HP:0002185)2.70946901
20Premature rupture of membranes (HP:0001788)2.69703104
21Muscle fiber splitting (HP:0003555)2.65146499
22Hyporeflexia of lower limbs (HP:0002600)2.64896961
23Cerebral aneurysm (HP:0004944)2.63055339
24Hyperacusis (HP:0010780)2.63035148
25Mildly elevated creatine phosphokinase (HP:0008180)2.62358243
26Ankle clonus (HP:0011448)2.59633834
27Supranuclear gaze palsy (HP:0000605)2.54672179
28Stridor (HP:0010307)2.53981675
29Broad metatarsal (HP:0001783)2.41150214
30Asymmetric septal hypertrophy (HP:0001670)2.37262106
31Lower limb amyotrophy (HP:0007210)2.36270435
32Cerebral inclusion bodies (HP:0100314)2.35370013
33Distal lower limb amyotrophy (HP:0008944)2.30687455
34Bundle branch block (HP:0011710)2.28495807
35Achilles tendon contracture (HP:0001771)2.25417198
36Bulbar palsy (HP:0001283)2.23760728
37Insomnia (HP:0100785)2.21184152
38Bladder diverticulum (HP:0000015)2.15803191
39Mitral regurgitation (HP:0001653)2.14163962
40Distal upper limb amyotrophy (HP:0007149)2.13832641
41Upper limb amyotrophy (HP:0009129)2.13832641
42Annular pancreas (HP:0001734)2.13257889
43Slender build (HP:0001533)2.12422714
44Torticollis (HP:0000473)2.08617969
45EMG: myopathic abnormalities (HP:0003458)2.08561006
46Ulnar bowing (HP:0003031)2.07270231
47Distal arthrogryposis (HP:0005684)2.07119741
48Lymphangioma (HP:0100764)2.06431103
49Myotonia (HP:0002486)2.06285999
50Abnormal atrioventricular conduction (HP:0005150)2.06153734
51Vertebral compression fractures (HP:0002953)2.02862136
52Muscle stiffness (HP:0003552)2.02688805
53Foot dorsiflexor weakness (HP:0009027)2.02517200
54Abnormality of the Achilles tendon (HP:0005109)2.00705185
55Sudden death (HP:0001699)2.00551704
56Calcaneovalgus deformity (HP:0001848)2.00276425
57Ulnar deviation of the wrist (HP:0003049)2.00161175
58Hypoventilation (HP:0002791)1.98929120
59Visual hallucinations (HP:0002367)1.98467208
60Abnormality of the aortic arch (HP:0012303)1.97808056
61Difficulty running (HP:0009046)1.95599253
62Abnormality of the left ventricular outflow tract (HP:0011103)1.94427264
63Subaortic stenosis (HP:0001682)1.94427264
64Aplasia involving bones of the extremities (HP:0009825)1.94275147
65Aplasia involving bones of the upper limbs (HP:0009823)1.94275147
66Aplasia of the phalanges of the hand (HP:0009802)1.94275147
67Heart block (HP:0012722)1.93719343
68Congenital malformation of the right heart (HP:0011723)1.92891767
69Double outlet right ventricle (HP:0001719)1.92891767
70Difficulty climbing stairs (HP:0003551)1.92870558
71Abnormality of the foot musculature (HP:0001436)1.91217093
72Fragile skin (HP:0001030)1.90694685
73Exercise-induced muscle cramps (HP:0003710)1.87964507
74Axonal loss (HP:0003447)1.87217477
75Hypercortisolism (HP:0001578)1.85098280
76Neck muscle weakness (HP:0000467)1.85001783
77Hyperthyroidism (HP:0000836)1.84598071
78Abnormality of the calf musculature (HP:0001430)1.82994322
79Diplopia (HP:0000651)1.79962513
80Abnormality of binocular vision (HP:0011514)1.79962513
81Ankle contracture (HP:0006466)1.79558270
82Sleep apnea (HP:0010535)1.78228453
83Muscle hypertrophy of the lower extremities (HP:0008968)1.77529206
84Action tremor (HP:0002345)1.77448001
85Bronchomalacia (HP:0002780)1.76840018
86Focal dystonia (HP:0004373)1.76726068
87Abnormal eating behavior (HP:0100738)1.76611229
88Deformed tarsal bones (HP:0008119)1.74112240
89Craniofacial dystonia (HP:0012179)1.74041479
90Truncus arteriosus (HP:0001660)1.73977412
91Vascular tortuosity (HP:0004948)1.73704275
92Genu recurvatum (HP:0002816)1.73591366
93Focal motor seizures (HP:0011153)1.72952860
94Hyperparathyroidism (HP:0000843)1.72790440
95Nuclear cataract (HP:0100018)1.72192117
96Coronal craniosynostosis (HP:0004440)1.71910455
97EMG: neuropathic changes (HP:0003445)1.71525703
98Focal seizures (HP:0007359)1.70615215
99Bowel diverticulosis (HP:0005222)1.68427721
100Partial duplication of the phalanx of hand (HP:0009999)1.65581438

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.53665140
2PRKD33.07909502
3RIPK12.75531816
4TTN2.58016929
5EPHA42.36449992
6MARK12.35229695
7PHKG12.26806065
8PHKG22.26806065
9PRPF4B2.17276235
10PAK62.17190610
11ICK2.12439816
12SIK12.03106077
13NTRK32.00064053
14NTRK11.99874796
15ARAF1.82697666
16EPHB21.81797463
17TESK11.76641264
18OBSCN1.66541670
19EEF2K1.64893459
20SMG11.59120809
21LATS21.55034068
22UHMK11.50143456
23DDR21.49706037
24MAP3K111.47948837
25DAPK21.46714751
26PDGFRA1.46599026
27TYRO31.45120426
28MARK21.41115342
29LIMK11.39959949
30NTRK21.35999604
31ERN11.33694420
32CAMKK11.27123663
33MAPK121.22991683
34GRK51.19188879
35DMPK1.18124110
36LMTK21.06674004
37PTK21.04889739
38BRAF1.02688979
39CAMK11.00579704
40TAOK20.99867810
41MAP3K90.99755664
42RPS6KA20.99346538
43CAMK2G0.97737965
44PRKD20.90605301
45CDC42BPA0.87154390
46MINK10.86201124
47CDK50.85690154
48CAMK2B0.85337710
49CDK11A0.83906553
50DAPK30.83458832
51CDK150.81754127
52PDPK10.81336191
53SIK20.80697377
54MOS0.79483497
55KSR20.77292187
56ABL20.76063381
57MAP3K70.75914829
58SGK4940.75134846
59SGK2230.75134846
60PRKG20.74808464
61PKN10.74548883
62CDK180.72628897
63PRKCH0.70443128
64DYRK1B0.70307321
65STK380.69839060
66NME20.69811613
67MTOR0.69442613
68IRAK30.68337125
69PKN20.67147494
70MYLK0.63882809
71CDK140.63801790
72CAMK2D0.63679463
73ROCK20.63616748
74MAPK40.63325832
75ROCK10.62910295
76FGFR40.60470255
77PINK10.60442129
78MAP2K40.59544143
79RPS6KL10.59525884
80RPS6KC10.59525884
81MAP3K60.58913231
82ILK0.58038774
83CAMK40.57679623
84TIE10.57353777
85MAP3K10.57212862
86STK110.56558446
87SGK30.55083780
88TAOK10.51876293
89IRAK20.51867883
90FGFR20.51694402
91HIPK20.51640186
92AKT20.51126247
93CDK190.50999320
94EPHA20.50763101
95PAK20.50713140
96BMX0.50691181
97MUSK0.50033673
98MAPK70.49899515
99MAPK100.49718696
100PRKD10.49374618

Predicted pathways (KEGG)

RankGene SetZ-score
1Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.35940015
2Synaptic vesicle cycle_Homo sapiens_hsa047212.32828553
3Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.97230175
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.82631694
5Dilated cardiomyopathy_Homo sapiens_hsa054141.81986892
6Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.78183368
7Long-term potentiation_Homo sapiens_hsa047201.74785458
8Insulin secretion_Homo sapiens_hsa049111.73363905
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.71313600
10Aldosterone synthesis and secretion_Homo sapiens_hsa049251.57856521
11Prion diseases_Homo sapiens_hsa050201.54897087
12Gastric acid secretion_Homo sapiens_hsa049711.51378967
13Cardiac muscle contraction_Homo sapiens_hsa042601.50877395
14Cocaine addiction_Homo sapiens_hsa050301.50637064
15Circadian entrainment_Homo sapiens_hsa047131.49946937
16Amphetamine addiction_Homo sapiens_hsa050311.47710186
17Sulfur relay system_Homo sapiens_hsa041221.44293771
18Notch signaling pathway_Homo sapiens_hsa043301.41560343
19Cyanoamino acid metabolism_Homo sapiens_hsa004601.41201351
20Arginine and proline metabolism_Homo sapiens_hsa003301.39685430
21Vitamin B6 metabolism_Homo sapiens_hsa007501.39566406
22Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.38890905
23Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.34339151
24Dopaminergic synapse_Homo sapiens_hsa047281.33102372
25Oxytocin signaling pathway_Homo sapiens_hsa049211.30053782
26GnRH signaling pathway_Homo sapiens_hsa049121.28014327
27Glutamatergic synapse_Homo sapiens_hsa047241.27188555
28Cholinergic synapse_Homo sapiens_hsa047251.25356718
29Melanogenesis_Homo sapiens_hsa049161.24947422
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.22719955
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.22394622
32Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.22290096
33GABAergic synapse_Homo sapiens_hsa047271.21718442
34Glioma_Homo sapiens_hsa052141.20808973
35Nicotine addiction_Homo sapiens_hsa050331.20158161
36Arginine biosynthesis_Homo sapiens_hsa002201.14740274
37VEGF signaling pathway_Homo sapiens_hsa043701.13993635
38Morphine addiction_Homo sapiens_hsa050321.13219765
39Axon guidance_Homo sapiens_hsa043601.13059388
40Insulin signaling pathway_Homo sapiens_hsa049101.11572477
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09850311
42AMPK signaling pathway_Homo sapiens_hsa041521.09055679
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08439586
44Calcium signaling pathway_Homo sapiens_hsa040201.05923369
45Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.05276469
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03458438
47Renin secretion_Homo sapiens_hsa049241.02743947
48Glucagon signaling pathway_Homo sapiens_hsa049221.02522269
49Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.01739393
50cAMP signaling pathway_Homo sapiens_hsa040241.00778850
51Phospholipase D signaling pathway_Homo sapiens_hsa040721.00293784
52Estrogen signaling pathway_Homo sapiens_hsa049150.99873420
53Focal adhesion_Homo sapiens_hsa045100.99473467
54ECM-receptor interaction_Homo sapiens_hsa045120.98131150
55Bile secretion_Homo sapiens_hsa049760.96672534
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.96546277
57Gap junction_Homo sapiens_hsa045400.96541924
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93635039
59Vibrio cholerae infection_Homo sapiens_hsa051100.92676810
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.92416039
61Phenylalanine metabolism_Homo sapiens_hsa003600.90826101
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89834581
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.89116446
64Salivary secretion_Homo sapiens_hsa049700.88166142
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82959093
66ErbB signaling pathway_Homo sapiens_hsa040120.82282171
67Fructose and mannose metabolism_Homo sapiens_hsa000510.79835628
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77028912
69PPAR signaling pathway_Homo sapiens_hsa033200.75296496
70Basal cell carcinoma_Homo sapiens_hsa052170.74850631
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74002409
72Galactose metabolism_Homo sapiens_hsa000520.73313842
73Biosynthesis of amino acids_Homo sapiens_hsa012300.73189600
74Protein digestion and absorption_Homo sapiens_hsa049740.71609920
75Long-term depression_Homo sapiens_hsa047300.69141047
76Tight junction_Homo sapiens_hsa045300.68880857
77Thyroid hormone synthesis_Homo sapiens_hsa049180.68538886
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.64789484
79mTOR signaling pathway_Homo sapiens_hsa041500.64406303
80Pentose phosphate pathway_Homo sapiens_hsa000300.64148070
81Rap1 signaling pathway_Homo sapiens_hsa040150.63876691
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.63832105
83Bladder cancer_Homo sapiens_hsa052190.63048292
84Histidine metabolism_Homo sapiens_hsa003400.62167479
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.62097473
86Amoebiasis_Homo sapiens_hsa051460.62081857
87MAPK signaling pathway_Homo sapiens_hsa040100.61402773
88Hippo signaling pathway_Homo sapiens_hsa043900.60916726
89Other glycan degradation_Homo sapiens_hsa005110.60362452
90Hedgehog signaling pathway_Homo sapiens_hsa043400.56883336
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56745460
92Endocytosis_Homo sapiens_hsa041440.55965666
93Endometrial cancer_Homo sapiens_hsa052130.54983912
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54887156
95Wnt signaling pathway_Homo sapiens_hsa043100.53784960
96Carbon metabolism_Homo sapiens_hsa012000.53307714
97Proteoglycans in cancer_Homo sapiens_hsa052050.50885734
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49844376
99Pancreatic secretion_Homo sapiens_hsa049720.48340455
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48042081

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