ZNF354B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.72173333
2monoubiquitinated protein deubiquitination (GO:0035520)5.25976911
3nuclear pore organization (GO:0006999)5.01613808
4negative regulation of DNA repair (GO:0045738)4.77169441
5interkinetic nuclear migration (GO:0022027)4.66701758
6lipid translocation (GO:0034204)4.34688527
7phospholipid translocation (GO:0045332)4.34688527
8regulation of pigment cell differentiation (GO:0050932)4.12145389
9pore complex assembly (GO:0046931)4.08967026
10innate immune response in mucosa (GO:0002227)3.99658303
11positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.94318886
12negative regulation of translation, ncRNA-mediated (GO:0040033)3.78516253
13regulation of translation, ncRNA-mediated (GO:0045974)3.78516253
14negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.78516253
15cytoplasmic mRNA processing body assembly (GO:0033962)3.74787566
16histone H3-K36 demethylation (GO:0070544)3.73899432
17pre-miRNA processing (GO:0031054)3.72543928
18cellular response to ethanol (GO:0071361)3.70039209
19positive regulation of developmental pigmentation (GO:0048087)3.68813236
20protein K48-linked deubiquitination (GO:0071108)3.57942389
21histone lysine demethylation (GO:0070076)3.56963898
22nucleus localization (GO:0051647)3.45332765
23cerebellar Purkinje cell differentiation (GO:0021702)3.44559344
24dosage compensation (GO:0007549)3.44104174
25histone demethylation (GO:0016577)3.38996655
26definitive hemopoiesis (GO:0060216)3.38118736
27regulation of establishment of cell polarity (GO:2000114)3.35611521
28coronary vasculature morphogenesis (GO:0060977)3.27338477
29mucosal immune response (GO:0002385)3.21226832
30labyrinthine layer development (GO:0060711)3.21097777
31mature B cell differentiation involved in immune response (GO:0002313)3.20540547
32phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.18416603
33mature B cell differentiation (GO:0002335)3.17871240
34embryonic camera-type eye morphogenesis (GO:0048596)3.15189542
35antibacterial humoral response (GO:0019731)3.09090582
36peptidyl-lysine dimethylation (GO:0018027)3.06396229
37spleen development (GO:0048536)3.02333831
38replicative senescence (GO:0090399)3.01534168
39histone H3-K9 demethylation (GO:0033169)3.01279375
40negative regulation of fatty acid transport (GO:2000192)3.01032295
41organ or tissue specific immune response (GO:0002251)2.99771548
42protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.92967995
43positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.90440969
44dorsal/ventral axis specification (GO:0009950)2.89974664
45negative regulation of myotube differentiation (GO:0010832)2.87616953
46DNA replication-dependent nucleosome assembly (GO:0006335)2.87376379
47DNA replication-dependent nucleosome organization (GO:0034723)2.87376379
48histone H3-K9 methylation (GO:0051567)2.86207955
49snRNA transcription (GO:0009301)2.85438605
50protein dealkylation (GO:0008214)2.84437756
51protein demethylation (GO:0006482)2.84437756
52fibroblast migration (GO:0010761)2.82134451
53embryonic process involved in female pregnancy (GO:0060136)2.81997399
54antimicrobial humoral response (GO:0019730)2.81786655
55regulation of establishment or maintenance of cell polarity (GO:0032878)2.80575828
56pericardium development (GO:0060039)2.78699972
57regulation of membrane lipid distribution (GO:0097035)2.76567479
58histone H3-K4 trimethylation (GO:0080182)2.75099729
59mesenchyme morphogenesis (GO:0072132)2.73855789
60establishment of nucleus localization (GO:0040023)2.73479515
61establishment of protein localization to Golgi (GO:0072600)2.73133443
62positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.72974213
63positive regulation of cation channel activity (GO:2001259)2.72930970
64peptidyl-lysine trimethylation (GO:0018023)2.71179396
65cartilage morphogenesis (GO:0060536)2.68933080
66positive regulation of DNA-templated transcription, initiation (GO:2000144)2.68541922
67morphogenesis of an epithelial sheet (GO:0002011)2.66956078
68insulin-like growth factor receptor signaling pathway (GO:0048009)2.66726265
69regulation of somitogenesis (GO:0014807)2.66617120
70molting cycle (GO:0042303)2.65961577
71hair cycle (GO:0042633)2.65961577
72peptidyl-lysine methylation (GO:0018022)2.65476626
73protein prenylation (GO:0018342)2.63433747
74prenylation (GO:0097354)2.63433747
75embryonic eye morphogenesis (GO:0048048)2.61321229
76centrosome duplication (GO:0051298)2.60782812
77regulation of RNA export from nucleus (GO:0046831)2.59081221
78positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.55996325
79heart morphogenesis (GO:0003007)2.55295941
80negative regulation of neurotransmitter secretion (GO:0046929)2.53849029
81central nervous system neuron axonogenesis (GO:0021955)2.53299940
82regulation of interleukin-12 biosynthetic process (GO:0045075)2.52952066
83histone lysine methylation (GO:0034968)2.51667445
84negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.48077014
85positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.46561171
86negative regulation of dendrite morphogenesis (GO:0050774)2.45229576
87embryonic retina morphogenesis in camera-type eye (GO:0060059)2.45017393
88T cell mediated immunity (GO:0002456)2.44543423
89positive regulation of cardiac muscle cell differentiation (GO:2000727)2.43300414
90regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.40598994
91glucocorticoid receptor signaling pathway (GO:0042921)2.39599054
92embryonic digit morphogenesis (GO:0042733)2.39130096
93histone H3-K9 modification (GO:0061647)2.38120485
94regulation of transforming growth factor beta2 production (GO:0032909)2.37239548
95SMAD protein complex assembly (GO:0007183)2.36722057
96regulation of fatty acid beta-oxidation (GO:0031998)2.36236731
97neural tube formation (GO:0001841)2.33814108
98Golgi to endosome transport (GO:0006895)2.32646552
99positive regulation of cell cycle checkpoint (GO:1901978)2.29504884
100regulation of DNA damage checkpoint (GO:2000001)2.28868308

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse6.02906045
2CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.00346033
3SMAD_19615063_ChIP-ChIP_OVARY_Human2.48213389
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.45502404
5GATA1_22025678_ChIP-Seq_K562_Human2.41841244
6STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.39056201
7TP53_16413492_ChIP-PET_HCT116_Human2.11026175
8ZNF217_24962896_ChIP-Seq_MCF-7_Human2.09692836
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse12.5838530
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99890826
11AHR_22903824_ChIP-Seq_MCF-7_Human1.94877814
12SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.94563862
13AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.89332871
14GBX2_23144817_ChIP-Seq_PC3_Human1.82844127
15RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.68383224
16SALL1_21062744_ChIP-ChIP_HESCs_Human1.65384076
17CDX2_19796622_ChIP-Seq_MESCs_Mouse1.64283024
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59994331
19AR_21572438_ChIP-Seq_LNCaP_Human1.58286767
20ARNT_22903824_ChIP-Seq_MCF-7_Human1.57009821
21CTNNB1_20460455_ChIP-Seq_HCT116_Human1.52787047
22RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50934695
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.49695244
24HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.44827150
25E2F4_17652178_ChIP-ChIP_JURKAT_Human1.44101823
26CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.42686926
27* STAT3_23295773_ChIP-Seq_U87_Human1.39413473
28EGR1_23403033_ChIP-Seq_LIVER_Mouse1.39257869
29FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.36840651
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33011105
31TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.32756027
32* SMAD4_21799915_ChIP-Seq_A2780_Human1.31027863
33SCL_19346495_ChIP-Seq_HPC-7_Human1.30396656
34PKCTHETA_26484144_Chip-Seq_BREAST_Human1.29028196
35E2F7_22180533_ChIP-Seq_HELA_Human1.22147224
36ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21958264
37TAF15_26573619_Chip-Seq_HEK293_Human1.19711014
38MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19671390
39FUS_26573619_Chip-Seq_HEK293_Human1.17559535
40EWS_26573619_Chip-Seq_HEK293_Human1.17099905
41SOX9_24532713_ChIP-Seq_HFSC_Mouse1.16662974
42FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.15945816
43FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15868362
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15837563
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13414298
46EZH2_22144423_ChIP-Seq_EOC_Human1.13354745
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13070971
48NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11426747
49NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11426747
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11245519
51NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.10377028
52ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09242311
53KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.08812695
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.08461161
55IGF1R_20145208_ChIP-Seq_DFB_Human1.08154100
56FOXO3_23340844_ChIP-Seq_DLD1_Human1.06342320
57SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.04654642
58BRD4_25478319_ChIP-Seq_HGPS_Human1.04465256
59* TCF4_23295773_ChIP-Seq_U87_Human1.03897658
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03518509
61FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03251366
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00976105
63SOX9_26525672_Chip-Seq_HEART_Mouse0.99951579
64TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99486138
65EP300_21415370_ChIP-Seq_HL-1_Mouse0.98846829
66SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95232287
67SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95232287
68STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.94563898
69FOXA2_19822575_ChIP-Seq_HepG2_Human0.94537860
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94319259
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94319259
72YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93594783
73ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93588442
74DROSHA_22980978_ChIP-Seq_HELA_Human0.92512224
75E2F1_21310950_ChIP-Seq_MCF-7_Human0.92455399
76BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91701079
77CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.89383590
78DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88967289
79NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87659541
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87471611
81CJUN_26792858_Chip-Seq_BT549_Human0.86834306
82P300_19829295_ChIP-Seq_ESCs_Human0.86421003
83SMAD3_21741376_ChIP-Seq_HESCs_Human0.86151010
84PPAR_26484153_Chip-Seq_NCI-H1993_Human0.84781362
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84325415
86ER_23166858_ChIP-Seq_MCF-7_Human0.82443450
87ESR1_20079471_ChIP-ChIP_T-47D_Human0.81660941
88TP53_18474530_ChIP-ChIP_U2OS_Human0.80936367
89SOX2_21211035_ChIP-Seq_LN229_Gbm0.79694259
90VDR_24787735_ChIP-Seq_THP-1_Human0.78905681
91VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.78343139
92SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.77801377
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.77570120
94FLI1_21867929_ChIP-Seq_TH2_Mouse0.76479121
95ISL1_27105846_Chip-Seq_CPCs_Mouse0.75777719
96WT1_25993318_ChIP-Seq_PODOCYTE_Human0.75512955
97IRF1_19129219_ChIP-ChIP_H3396_Human0.75472811
98TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.75268628
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.75190931
100CBP_20019798_ChIP-Seq_JUKART_Human0.75190931

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.30628456
2MP0008057_abnormal_DNA_replication5.81316699
3MP0002009_preneoplasia3.82179098
4MP0010352_gastrointestinal_tract_polyps3.64521901
5MP0005076_abnormal_cell_differentiation2.72343170
6MP0003705_abnormal_hypodermis_morpholog2.40534748
7MP0002396_abnormal_hematopoietic_system2.26697158
8MP0010307_abnormal_tumor_latency2.22725311
9MP0001879_abnormal_lymphatic_vessel2.21024348
10MP0003045_fibrosis2.17201451
11MP0002166_altered_tumor_susceptibility2.00178301
12MP0005409_darkened_coat_color1.93075406
13MP0000383_abnormal_hair_follicle1.86670206
14MP0000733_abnormal_muscle_development1.71371242
15MP0003890_abnormal_embryonic-extraembry1.57783697
16MP0010386_abnormal_urinary_bladder1.55653998
17MP0000003_abnormal_adipose_tissue1.54878413
18MP0002638_abnormal_pupillary_reflex1.54219163
19MP0004808_abnormal_hematopoietic_stem1.50733820
20MP0004185_abnormal_adipocyte_glucose1.50566965
21MP0003937_abnormal_limbs/digits/tail_de1.48871257
22MP0005275_abnormal_skin_tensile1.48598964
23MP0010678_abnormal_skin_adnexa1.47135125
24MP0002006_tumorigenesis1.46616002
25MP0003091_abnormal_cell_migration1.43865635
26MP0000537_abnormal_urethra_morphology1.41877458
27MP0000538_abnormal_urinary_bladder1.39813782
28MP0003868_abnormal_feces_composition1.26202127
29MP0000428_abnormal_craniofacial_morphol1.26188045
30MP0004130_abnormal_muscle_cell1.26029258
31MP0002168_other_aberrant_phenotype1.25336393
32MP0003935_abnormal_craniofacial_develop1.22752965
33MP0008961_abnormal_basal_metabolism1.19038893
34MP0008438_abnormal_cutaneous_collagen1.18876200
35MP0003077_abnormal_cell_cycle1.18426190
36MP0003252_abnormal_bile_duct1.16483661
37MP0005220_abnormal_exocrine_pancreas1.16182525
38MP0005187_abnormal_penis_morphology1.13718696
39MP0004134_abnormal_chest_morphology1.13172984
40MP0002086_abnormal_extraembryonic_tissu1.11894311
41MP0000371_diluted_coat_color1.10182648
42MP0003632_abnormal_nervous_system1.09658479
43MP0001958_emphysema1.03497205
44MP0009115_abnormal_fat_cell1.03004808
45MP0008770_decreased_survivor_rate1.01446249
46MP0004145_abnormal_muscle_electrophysio0.98912077
47MP0003385_abnormal_body_wall0.97625651
48MP0001661_extended_life_span0.97409282
49MP0003221_abnormal_cardiomyocyte_apopto0.97059291
50MP0002697_abnormal_eye_size0.95502996
51MP0003984_embryonic_growth_retardation0.95212640
52MP0002928_abnormal_bile_duct0.94875810
53MP0002088_abnormal_embryonic_growth/wei0.94618829
54MP0005375_adipose_tissue_phenotype0.94260148
55MP0004264_abnormal_extraembryonic_tissu0.92059501
56MP0003115_abnormal_respiratory_system0.90316434
57MP0002925_abnormal_cardiovascular_devel0.88683710
58MP0002109_abnormal_limb_morphology0.88267509
59MP0002114_abnormal_axial_skeleton0.87475685
60MP0001440_abnormal_grooming_behavior0.87104884
61MP0004197_abnormal_fetal_growth/weight/0.86785205
62MP0005645_abnormal_hypothalamus_physiol0.86745285
63MP0002735_abnormal_chemical_nociception0.86103047
64MP0002160_abnormal_reproductive_system0.85709808
65MP0000432_abnormal_head_morphology0.85240852
66MP0002933_joint_inflammation0.84136473
67MP0003942_abnormal_urinary_system0.82817050
68MP0002108_abnormal_muscle_morphology0.82612396
69MP0000013_abnormal_adipose_tissue0.81843557
70MP0002084_abnormal_developmental_patter0.80692695
71MP0005666_abnormal_adipose_tissue0.80447328
72MP0001915_intracranial_hemorrhage0.79810296
73MP0001177_atelectasis0.76937638
74MP0004036_abnormal_muscle_relaxation0.76587186
75MP0005174_abnormal_tail_pigmentation0.74926743
76MP0001175_abnormal_lung_morphology0.73960919
77MP0003828_pulmonary_edema0.72186562
78MP0001784_abnormal_fluid_regulation0.71021481
79MP0005380_embryogenesis_phenotype0.70076641
80MP0001672_abnormal_embryogenesis/_devel0.70076641
81MP0005171_absent_coat_pigmentation0.69782406
82MP0004272_abnormal_basement_membrane0.68520070
83MP0005083_abnormal_biliary_tract0.68178643
84MP0005621_abnormal_cell_physiology0.65970473
85MP0005647_abnormal_sex_gland0.65792893
86MP0009697_abnormal_copulation0.65766424
87MP0005310_abnormal_salivary_gland0.64889733
88MP0001270_distended_abdomen0.64819726
89MP0010094_abnormal_chromosome_stability0.63849382
90MP0004084_abnormal_cardiac_muscle0.63821594
91MP0003111_abnormal_nucleus_morphology0.63646456
92MP0009250_abnormal_appendicular_skeleto0.62995611
93MP0006138_congestive_heart_failure0.62180651
94MP0003183_abnormal_peptide_metabolism0.61907841
95MP0002135_abnormal_kidney_morphology0.61827507
96MP0002075_abnormal_coat/hair_pigmentati0.61807114
97MP0003959_abnormal_lean_body0.61048361
98MP0009703_decreased_birth_body0.59984657
99MP0008007_abnormal_cellular_replicative0.58855839
100MP0004233_abnormal_muscle_weight0.58640328

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)5.13833979
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)5.13833979
3Neoplasm of the heart (HP:0100544)4.66884774
4Genetic anticipation (HP:0003743)3.77482464
5Abnormality of the 4th metacarpal (HP:0010012)3.68549975
6Abnormality of the distal phalanx of the thumb (HP:0009617)3.60002265
7Abnormality of the parietal bone (HP:0002696)3.48855257
8Hyperventilation (HP:0002883)3.30688941
9Medulloblastoma (HP:0002885)3.15357347
10Dysmetric saccades (HP:0000641)3.11870581
11Abnormality of the fingertips (HP:0001211)3.02364502
12Colitis (HP:0002583)2.77460876
13Short phalanx of the thumb (HP:0009660)2.70276460
14Subacute progressive viral hepatitis (HP:0006572)2.69024378
15Protruding tongue (HP:0010808)2.64870437
16Down-sloping shoulders (HP:0200021)2.64627343
17Asymmetry of the thorax (HP:0001555)2.61135885
18Abnormality of the renal collecting system (HP:0004742)2.60320476
19Acute myeloid leukemia (HP:0004808)2.57383892
20Supernumerary ribs (HP:0005815)2.56263425
21Spinal cord lesions (HP:0100561)2.51473676
22Syringomyelia (HP:0003396)2.51473676
23Deformed sella turcica (HP:0002681)2.50503102
24Narrow palate (HP:0000189)2.47646381
25Aortic aneurysm (HP:0004942)2.45794029
26Sandal gap (HP:0001852)2.43148154
27Overgrowth (HP:0001548)2.42241438
28Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.41743619
29Neoplasm of the oral cavity (HP:0100649)2.40510201
30Hamartoma (HP:0010566)2.39206158
31Duplicated collecting system (HP:0000081)2.38094789
32Gaze-evoked nystagmus (HP:0000640)2.36588460
33Papillary thyroid carcinoma (HP:0002895)2.31537691
34Abnormality of the sella turcica (HP:0002679)2.31416875
35Neoplasm of striated muscle (HP:0009728)2.30671182
36Persistence of primary teeth (HP:0006335)2.29663348
37Thyroiditis (HP:0100646)2.28932627
38Chromosomal breakage induced by crosslinking agents (HP:0003221)2.28198460
39Short chin (HP:0000331)2.25698146
40Supernumerary bones of the axial skeleton (HP:0009144)2.24308442
41Prominent nose (HP:0000448)2.22872198
42Abnormality of the epiphyses of the hand (HP:0005924)2.20064527
43Abnormality of DNA repair (HP:0003254)2.15590166
44Interstitial pulmonary disease (HP:0006530)2.15151319
45Impaired smooth pursuit (HP:0007772)2.12333659
46Fair hair (HP:0002286)2.11227509
47Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.10586993
48Submucous cleft hard palate (HP:0000176)2.09924020
49Milia (HP:0001056)2.09416603
50Abnormality involving the epiphyses of the upper limbs (HP:0003839)2.06368353
51Broad ribs (HP:0000885)2.06042952
52Progressive cerebellar ataxia (HP:0002073)2.05327624
53IgA deficiency (HP:0002720)2.04825436
54Sparse lateral eyebrow (HP:0005338)2.03141960
55Neonatal hypoglycemia (HP:0001998)2.01079977
56IgM deficiency (HP:0002850)2.00872975
57Long eyelashes (HP:0000527)2.00470315
58Relative macrocephaly (HP:0004482)1.99876959
59Chromsome breakage (HP:0040012)1.99789783
60Fibrous tissue neoplasm (HP:0012316)1.98820136
61Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.97786931
62Hypoplasia of the iris (HP:0007676)1.96879562
63Truncal obesity (HP:0001956)1.95262916
64Fibroma (HP:0010614)1.94577631
65Aortic regurgitation (HP:0001659)1.93374603
66Abnormality of the ischium (HP:0003174)1.87775774
67Aortic dissection (HP:0002647)1.81831547
68Vertebral arch anomaly (HP:0008438)1.81163423
69Abnormal ossification of hand bones (HP:0005921)1.77570944
70Germ cell neoplasia (HP:0100728)1.77112394
71Skin pits (HP:0100276)1.76808455
72Ectopic kidney (HP:0000086)1.76671245
73Decreased lacrimation (HP:0000633)1.76133909
74Abnormal hand bone ossification (HP:0010660)1.76039038
75Abnormality of the nasal septum (HP:0000419)1.73930504
76Urinary bladder sphincter dysfunction (HP:0002839)1.71374655
77Mitral valve prolapse (HP:0001634)1.70439184
78Hypoplasia of the maxilla (HP:0000327)1.69153453
79Lip pit (HP:0100267)1.68525853
80Abnormality of the columella (HP:0009929)1.68356945
81Flat acetabular roof (HP:0003180)1.67647576
82Dislocated radial head (HP:0003083)1.67146161
83Thick eyebrow (HP:0000574)1.66218069
84Acute lymphatic leukemia (HP:0006721)1.66136893
85Curly hair (HP:0002212)1.65972488
86Generalized hypopigmentation of hair (HP:0011358)1.65683435
87Entropion (HP:0000621)1.64526265
88Midline defect of the nose (HP:0004122)1.64516724
89Macroorchidism (HP:0000053)1.64489620
90Deeply set eye (HP:0000490)1.64235787
91Hypoplastic nipples (HP:0002557)1.63981745
92Large earlobe (HP:0009748)1.63767401
93Increased number of teeth (HP:0011069)1.63484259
94Hypoplastic labia majora (HP:0000059)1.63050498
95Malignant neoplasm of the central nervous system (HP:0100836)1.62443868
96Tented upper lip vermilion (HP:0010804)1.61081310
97Abnormality of the labia majora (HP:0012881)1.60426805
98Chronic hepatic failure (HP:0100626)1.60091474
99Astrocytoma (HP:0009592)1.58790960
100Abnormality of the astrocytes (HP:0100707)1.58790960

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.39446794
2ZAK4.37624110
3AKT34.06160123
4FRK3.78868362
5MAP3K43.09463606
6CDK122.76263027
7ACVR1B2.53594360
8MAP2K72.53121740
9PKN22.51232777
10TRIB32.46731367
11CAMK1D2.26233332
12MAP2K41.97520653
13CAMK1G1.96065898
14BRD41.90146025
15SGK21.87781818
16RPS6KA51.66069975
17EPHA31.54340260
18ICK1.52797674
19BLK1.47129321
20RET1.45472791
21EEF2K1.42701491
22SGK31.40986364
23SGK2231.40639384
24SGK4941.40639384
25LATS11.33194893
26BMPR1B1.27411238
27MARK21.22335324
28WNK11.21678527
29NEK91.20941548
30MAP3K61.19228573
31MAP3K21.17401082
32NLK1.15731317
33PDGFRB1.12687670
34MELK1.08813677
35VRK11.01387542
36MKNK20.95363157
37MTOR0.93699356
38MAP3K100.92211795
39TRPM70.91917257
40PDGFRA0.91454300
41RPS6KB20.90531503
42FGFR30.89566956
43CAMK40.86922348
44PIK3CG0.85338959
45MAPK110.83015540
46INSRR0.81862156
47CSNK1A1L0.81088771
48STK38L0.80863047
49FLT30.80661896
50PKN10.80412482
51BTK0.79676363
52CAMKK20.77469106
53IRAK10.76245643
54PRKAA10.74622051
55PIM10.73696194
56MAP3K70.69868844
57PRKAA20.67365888
58CDK80.66347567
59PBK0.64443598
60MAP2K30.64034460
61CAMKK10.63192152
62CCNB10.62792849
63CDK60.62681604
64SGK10.62580590
65DMPK0.59887722
66CASK0.59262803
67SCYL20.58380901
68DAPK30.53046661
69OBSCN0.52596203
70RPS6KA60.50509888
71TTN0.47897239
72CHEK20.47699904
73STK40.47618327
74RPS6KC10.47564116
75RPS6KL10.47564116
76ERBB20.44469551
77STK110.40674278
78HCK0.40647488
79FER0.39640094
80BRSK20.38940103
81CDC70.38868456
82ATM0.37429609
83PIK3CA0.37079638
84RPS6KB10.35698696
85IRAK20.34511876
86CHEK10.34276014
87RPS6KA20.33594137
88NEK60.32084037
89JAK20.31774004
90CHUK0.31689037
91TEC0.31480130
92ATR0.30469889
93MAPK10.30164703
94AKT10.28479207
95MET0.27351369
96MAPK80.26412376
97GSK3B0.26333336
98MAPK100.25223030
99RPS6KA30.24482501
100HIPK20.23959387

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053225.76008841
2Alcoholism_Homo sapiens_hsa050344.38077900
3Viral carcinogenesis_Homo sapiens_hsa052032.14799886
4Non-small cell lung cancer_Homo sapiens_hsa052231.71303274
5Transcriptional misregulation in cancer_Homo sapiens_hsa052021.67030209
6Glioma_Homo sapiens_hsa052141.66071934
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.63617548
8Pancreatic cancer_Homo sapiens_hsa052121.61019600
9mTOR signaling pathway_Homo sapiens_hsa041501.52217326
10MicroRNAs in cancer_Homo sapiens_hsa052061.44889465
11Chronic myeloid leukemia_Homo sapiens_hsa052201.42797510
12Phosphatidylinositol signaling system_Homo sapiens_hsa040701.40787830
13Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.37251934
14ErbB signaling pathway_Homo sapiens_hsa040121.36175808
15Colorectal cancer_Homo sapiens_hsa052101.35756237
16AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.34657711
17Small cell lung cancer_Homo sapiens_hsa052221.33985470
18Prolactin signaling pathway_Homo sapiens_hsa049171.32184097
19Lysine degradation_Homo sapiens_hsa003101.30546282
20Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.24318971
21Type II diabetes mellitus_Homo sapiens_hsa049301.23728550
22Inositol phosphate metabolism_Homo sapiens_hsa005621.23189003
23Prostate cancer_Homo sapiens_hsa052151.20589185
24Dorso-ventral axis formation_Homo sapiens_hsa043201.19934612
25FoxO signaling pathway_Homo sapiens_hsa040681.17555338
26Longevity regulating pathway - mammal_Homo sapiens_hsa042111.10313942
27Choline metabolism in cancer_Homo sapiens_hsa052311.10057991
28Melanoma_Homo sapiens_hsa052181.09850691
29B cell receptor signaling pathway_Homo sapiens_hsa046621.09667636
30Endometrial cancer_Homo sapiens_hsa052131.09283845
31Renal cell carcinoma_Homo sapiens_hsa052111.04752819
32Adherens junction_Homo sapiens_hsa045201.04625105
33Cholinergic synapse_Homo sapiens_hsa047251.02033835
34Neurotrophin signaling pathway_Homo sapiens_hsa047221.01842253
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01331863
36Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.01110804
37Focal adhesion_Homo sapiens_hsa045100.99715494
38Acute myeloid leukemia_Homo sapiens_hsa052210.99478935
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.99160593
40GnRH signaling pathway_Homo sapiens_hsa049120.95769260
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.95268156
42Hedgehog signaling pathway_Homo sapiens_hsa043400.93509214
43VEGF signaling pathway_Homo sapiens_hsa043700.92975971
44Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92592899
45Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91219333
46Phospholipase D signaling pathway_Homo sapiens_hsa040720.90481690
47Proteoglycans in cancer_Homo sapiens_hsa052050.87274154
48Platelet activation_Homo sapiens_hsa046110.86400220
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.84287981
50Fanconi anemia pathway_Homo sapiens_hsa034600.83936654
51TNF signaling pathway_Homo sapiens_hsa046680.83172433
52Fatty acid biosynthesis_Homo sapiens_hsa000610.82839772
53TGF-beta signaling pathway_Homo sapiens_hsa043500.82249917
54Insulin resistance_Homo sapiens_hsa049310.82016896
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81012534
56Pathways in cancer_Homo sapiens_hsa052000.80590130
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79875957
58Hepatitis B_Homo sapiens_hsa051610.78952997
59cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75898624
60ECM-receptor interaction_Homo sapiens_hsa045120.75368102
61MAPK signaling pathway_Homo sapiens_hsa040100.72643319
62Circadian rhythm_Homo sapiens_hsa047100.71694250
63Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71228047
64Basal cell carcinoma_Homo sapiens_hsa052170.69256470
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69096204
66Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67751014
67HIF-1 signaling pathway_Homo sapiens_hsa040660.67383752
68Estrogen signaling pathway_Homo sapiens_hsa049150.67322519
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.66110425
70Long-term potentiation_Homo sapiens_hsa047200.65903308
71Taste transduction_Homo sapiens_hsa047420.64646809
72Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63709684
73T cell receptor signaling pathway_Homo sapiens_hsa046600.62357693
74Renin secretion_Homo sapiens_hsa049240.62344321
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.62057638
76p53 signaling pathway_Homo sapiens_hsa041150.60868500
77Oxytocin signaling pathway_Homo sapiens_hsa049210.60817833
78ABC transporters_Homo sapiens_hsa020100.59367858
79Osteoclast differentiation_Homo sapiens_hsa043800.59160703
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.58338882
81Thyroid cancer_Homo sapiens_hsa052160.56877250
82Gap junction_Homo sapiens_hsa045400.55397674
83cAMP signaling pathway_Homo sapiens_hsa040240.55171882
84Notch signaling pathway_Homo sapiens_hsa043300.54232329
85Glutamatergic synapse_Homo sapiens_hsa047240.53807644
86Protein digestion and absorption_Homo sapiens_hsa049740.51887460
87Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51457430
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.51133355
89Bladder cancer_Homo sapiens_hsa052190.51007279
90Insulin signaling pathway_Homo sapiens_hsa049100.50569601
91Calcium signaling pathway_Homo sapiens_hsa040200.50563664
92Cell cycle_Homo sapiens_hsa041100.50244949
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47954263
94Wnt signaling pathway_Homo sapiens_hsa043100.46773038
95Hepatitis C_Homo sapiens_hsa051600.46531248
96Toxoplasmosis_Homo sapiens_hsa051450.46242416
97HTLV-I infection_Homo sapiens_hsa051660.46089720
98Apoptosis_Homo sapiens_hsa042100.45708291
99Pancreatic secretion_Homo sapiens_hsa049720.45305606
100Long-term depression_Homo sapiens_hsa047300.44780769

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