ZNF354A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1urate metabolic process (GO:0046415)8.55717472
2phosphate ion transmembrane transport (GO:0035435)7.92916616
3negative regulation of cAMP-mediated signaling (GO:0043951)7.18598322
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.17178260
5response to parathyroid hormone (GO:0071107)6.50994089
6aminoglycoside antibiotic metabolic process (GO:0030647)6.38292804
7regulation of RNA export from nucleus (GO:0046831)6.28431890
8tachykinin receptor signaling pathway (GO:0007217)6.14258673
9regulation of hippo signaling (GO:0035330)5.89923390
10positive regulation of uterine smooth muscle contraction (GO:0070474)5.66757711
11regulation of natural killer cell differentiation (GO:0032823)5.24384262
12energy homeostasis (GO:0097009)5.17744770
13histone H4-K12 acetylation (GO:0043983)5.01185571
14detection of bacterium (GO:0016045)4.98989850
15trivalent inorganic anion homeostasis (GO:0072506)4.95799431
16phosphate ion homeostasis (GO:0055062)4.95799431
17transmission of nerve impulse (GO:0019226)4.91139744
18regulation of nucleobase-containing compound transport (GO:0032239)4.86452991
19hyperosmotic salinity response (GO:0042538)4.79909024
20peristalsis (GO:0030432)4.70667942
21response to lead ion (GO:0010288)4.64840497
22response to mercury ion (GO:0046689)4.57099499
23detection of other organism (GO:0098543)4.53362321
24positive regulation of action potential (GO:0045760)4.48428663
25regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.42477702
26regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.42477702
27maternal behavior (GO:0042711)4.41696029
28pyrimidine dimer repair (GO:0006290)4.40146320
29sensory perception of taste (GO:0050909)4.36112083
30negative regulation of heart rate (GO:0010459)4.35824454
31regulation of uterine smooth muscle contraction (GO:0070472)4.33388831
32negative regulation of protein localization to cell surface (GO:2000009)4.30621980
33regulation of dopamine metabolic process (GO:0042053)4.29502931
34regulation of catecholamine metabolic process (GO:0042069)4.29502931
35head development (GO:0060322)4.22039235
36behavioral response to nicotine (GO:0035095)4.18583345
37detection of light stimulus involved in sensory perception (GO:0050962)4.06413978
38detection of light stimulus involved in visual perception (GO:0050908)4.06413978
39parental behavior (GO:0060746)3.97812628
40pentose metabolic process (GO:0019321)3.93869047
41positive regulation of heart rate (GO:0010460)3.86247148
42positive regulation of histone H3-K4 methylation (GO:0051571)3.61421026
43histone H4 acetylation (GO:0043967)3.59645433
44regulation of Golgi to plasma membrane protein transport (GO:0042996)3.59103365
45response to magnesium ion (GO:0032026)3.57671959
46positive regulation of calcium ion import (GO:0090280)3.51270925
47negative regulation of synaptic transmission, GABAergic (GO:0032229)3.49670493
48negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.47767793
49DNA methylation involved in gamete generation (GO:0043046)3.41075057
50positive regulation of CREB transcription factor activity (GO:0032793)3.41013467
51positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)3.38552512
52synapsis (GO:0007129)3.37980306
53glycoside metabolic process (GO:0016137)3.37024587
54regulation of synaptic transmission, dopaminergic (GO:0032225)3.35326032
55regulation of G0 to G1 transition (GO:0070316)3.31266459
56regulation of meiosis I (GO:0060631)3.29351596
57substrate-independent telencephalic tangential migration (GO:0021826)3.28620591
58substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.28620591
59response to growth hormone (GO:0060416)3.25412637
60protein localization to cilium (GO:0061512)3.24684173
61photoreceptor cell maintenance (GO:0045494)3.24613657
62glycoprotein catabolic process (GO:0006516)3.18922048
63cytokine production involved in immune response (GO:0002367)3.18417198
64epoxygenase P450 pathway (GO:0019373)3.18395905
65gene silencing by RNA (GO:0031047)3.17692495
66indole-containing compound metabolic process (GO:0042430)3.16972879
67embryonic digestive tract development (GO:0048566)3.12669026
68opioid receptor signaling pathway (GO:0038003)3.10940295
69chromatin silencing (GO:0006342)3.10735215
70regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.09619252
71negative regulation of JAK-STAT cascade (GO:0046426)3.06481113
72cell redox homeostasis (GO:0045454)3.06223351
73maturation of 5.8S rRNA (GO:0000460)3.05669585
74photoreceptor cell development (GO:0042461)3.00320947
75negative regulation of Rho protein signal transduction (GO:0035024)2.98932463
76response to vitamin A (GO:0033189)2.98326967
77dentate gyrus development (GO:0021542)2.97194777
78piRNA metabolic process (GO:0034587)2.95269647
79regulation of natural killer cell activation (GO:0032814)2.93183503
80regulation of neurotransmitter uptake (GO:0051580)2.93101673
81negative regulation of neurological system process (GO:0031645)2.91538077
82negative regulation of dendrite development (GO:2000171)2.89497399
83nephron epithelium morphogenesis (GO:0072088)2.83717558
84nephron tubule morphogenesis (GO:0072078)2.83717558
85negative regulation of gene expression, epigenetic (GO:0045814)2.83158109
86regulation of feeding behavior (GO:0060259)2.82335710
87protein K48-linked deubiquitination (GO:0071108)2.82006592
88cardiac right ventricle morphogenesis (GO:0003215)2.81946654
89regulation of action potential (GO:0098900)2.80819686
90positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.78843454
91spliceosomal snRNP assembly (GO:0000387)2.78250610
92positive regulation of mitochondrial fission (GO:0090141)2.78126357
93sleep (GO:0030431)2.77128299
94tricarboxylic acid metabolic process (GO:0072350)2.75826435
95gene silencing (GO:0016458)2.75449236
96regulation of mitotic spindle checkpoint (GO:1903504)2.73309705
97regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.73309705
98histone H2A acetylation (GO:0043968)13.1931627
99phosphate ion transport (GO:0006817)10.9100354
100peptidyl-tyrosine autophosphorylation (GO:0038083)10.0898294

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.83231146
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.76362612
3EZH2_22144423_ChIP-Seq_EOC_Human2.95706632
4FUS_26573619_Chip-Seq_HEK293_Human2.67272862
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.61551003
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.29984230
7CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03506282
8GATA1_22025678_ChIP-Seq_K562_Human13.6181481
9GBX2_23144817_ChIP-Seq_PC3_Human1.98585963
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89258371
11ZNF263_19887448_ChIP-Seq_K562_Human1.85711888
12MYC_18940864_ChIP-ChIP_HL60_Human1.83897505
13UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.83427315
14ELF1_17652178_ChIP-ChIP_JURKAT_Human1.82744660
15ER_23166858_ChIP-Seq_MCF-7_Human1.82300500
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81141044
17VDR_22108803_ChIP-Seq_LS180_Human1.66831793
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.63235408
19POU3F2_20337985_ChIP-ChIP_501MEL_Human1.62279286
20ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60637780
21IGF1R_20145208_ChIP-Seq_DFB_Human1.57566101
22ELK1_19687146_ChIP-ChIP_HELA_Human1.54957717
23NR3C1_21868756_ChIP-Seq_MCF10A_Human1.53415318
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.52297106
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51682793
26TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42356718
27IRF8_22096565_ChIP-ChIP_GC-B_Human1.41515020
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39335299
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38786269
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.37781523
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.35548222
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.34325064
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32280747
34* STAT3_23295773_ChIP-Seq_U87_Human1.30977207
35AR_25329375_ChIP-Seq_VCAP_Human1.30524765
36RUNX2_22187159_ChIP-Seq_PCA_Human1.30318388
37EWS_26573619_Chip-Seq_HEK293_Human1.29589435
38KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28194470
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.28106643
40AUTS2_25519132_ChIP-Seq_293T-REX_Human1.27634937
41RXR_22108803_ChIP-Seq_LS180_Human1.23147816
42P300_19829295_ChIP-Seq_ESCs_Human1.22469904
43MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21940059
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21920399
45CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21294742
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.20188440
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.19438457
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18443197
49SMAD4_21741376_ChIP-Seq_EPCs_Human1.17900998
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.13805004
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13209484
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.09032811
53GATA1_26923725_Chip-Seq_HPCs_Mouse1.08885263
54TCF4_22108803_ChIP-Seq_LS180_Human1.05487310
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05088369
56FLI1_21867929_ChIP-Seq_TH2_Mouse1.04990834
57SMAD4_21799915_ChIP-Seq_A2780_Human1.04879393
58CMYC_18555785_Chip-Seq_ESCs_Mouse1.04791830
59PRDM14_20953172_ChIP-Seq_ESCs_Human1.04716030
60NCOR_22424771_ChIP-Seq_293T_Human1.04290377
61P300_18555785_Chip-Seq_ESCs_Mouse1.04173076
62E2F1_18555785_Chip-Seq_ESCs_Mouse0.99677112
63FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99298119
64KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98477702
65NANOG_18555785_Chip-Seq_ESCs_Mouse0.97776422
66CRX_20693478_ChIP-Seq_RETINA_Mouse0.96944681
67* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95493489
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95301687
69E2F4_17652178_ChIP-ChIP_JURKAT_Human0.95198148
70DROSHA_22980978_ChIP-Seq_HELA_Human0.93209190
71SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92463363
72SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.92241133
73IKZF1_21737484_ChIP-ChIP_HCT116_Human0.91536421
74BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91180605
75SOX2_18555785_Chip-Seq_ESCs_Mouse0.90834508
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90614223
77ESET_19884257_ChIP-Seq_ESCs_Mouse0.90441461
78TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88962865
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88846061
80TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.88731400
81STAT3_18555785_Chip-Seq_ESCs_Mouse0.87353978
82BMI1_23680149_ChIP-Seq_NPCS_Mouse0.87041515
83STAT1_17558387_ChIP-Seq_HELA_Human0.86678065
84NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.86628916
85REST_18959480_ChIP-ChIP_MESCs_Mouse0.86510040
86CDX2_22108803_ChIP-Seq_LS180_Human0.84696901
87CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.83458363
88FOXH1_21741376_ChIP-Seq_ESCs_Human0.83396899
89STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.82021240
90TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.81719587
91OCT4_21477851_ChIP-Seq_ESCs_Mouse0.81430113
92P53_22387025_ChIP-Seq_ESCs_Mouse0.80967064
93* VDR_23849224_ChIP-Seq_CD4+_Human0.79797588
94CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79579470
95ELK4_26923725_Chip-Seq_MESODERM_Mouse0.79453426
96GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.78400686
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.78349232
98NMYC_18555785_Chip-Seq_ESCs_Mouse0.78336846
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.77559346
100SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.77488637

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.30941008
2MP0003878_abnormal_ear_physiology5.30941008
3MP0001545_abnormal_hematopoietic_system4.06050003
4MP0005397_hematopoietic_system_phenotyp4.06050003
5MP0004147_increased_porphyrin_level3.21049669
6MP0005645_abnormal_hypothalamus_physiol3.12913227
7MP0004510_myositis2.98526182
8MP0008877_abnormal_DNA_methylation2.90353141
9MP0002138_abnormal_hepatobiliary_system2.62396219
10MP0004808_abnormal_hematopoietic_stem2.48172245
11MP0005367_renal/urinary_system_phenotyp2.47781122
12MP0000516_abnormal_urinary_system2.47781122
13MP0002160_abnormal_reproductive_system2.41342263
14MP0001486_abnormal_startle_reflex2.31515830
15MP0005551_abnormal_eye_electrophysiolog2.10989895
16MP0000427_abnormal_hair_cycle2.06184636
17MP0006072_abnormal_retinal_apoptosis2.03908207
18MP0004019_abnormal_vitamin_homeostasis2.02658925
19MP0002102_abnormal_ear_morphology1.97111879
20MP0001348_abnormal_lacrimal_gland1.93176495
21MP0006276_abnormal_autonomic_nervous1.87434178
22MP0001485_abnormal_pinna_reflex1.79237566
23MP0002332_abnormal_exercise_endurance1.77225448
24MP0002735_abnormal_chemical_nociception1.72873688
25MP0001501_abnormal_sleep_pattern1.69952414
26MP0004215_abnormal_myocardial_fiber1.66758794
27MP0009672_abnormal_birth_weight1.63745699
28MP0005389_reproductive_system_phenotype1.60522018
29MP0001764_abnormal_homeostasis1.58809486
30MP0000383_abnormal_hair_follicle1.58786092
31MP0005319_abnormal_enzyme/_coenzyme1.49059733
32MP0010678_abnormal_skin_adnexa1.46362565
33MP0003045_fibrosis1.43106903
34MP0006035_abnormal_mitochondrial_morpho1.41999189
35MP0004133_heterotaxia1.39161440
36MP0004085_abnormal_heartbeat1.37916511
37MP0003763_abnormal_thymus_physiology1.37553719
38MP0009333_abnormal_splenocyte_physiolog1.34906783
39MP0005647_abnormal_sex_gland1.29756403
40MP0009765_abnormal_xenobiotic_induced1.28098384
41MP0005253_abnormal_eye_physiology1.27677437
42MP0006292_abnormal_olfactory_placode1.24532908
43MP0005220_abnormal_exocrine_pancreas1.24466902
44MP0005195_abnormal_posterior_eye1.19583475
45MP0000538_abnormal_urinary_bladder1.17956203
46MP0003183_abnormal_peptide_metabolism1.15735798
47MP0008775_abnormal_heart_ventricle1.15538600
48MP0000678_abnormal_parathyroid_gland1.12427392
49MP0010386_abnormal_urinary_bladder1.10595209
50MP0003252_abnormal_bile_duct1.07912840
51MP0000749_muscle_degeneration1.05691630
52MP0000372_irregular_coat_pigmentation1.05636452
53MP0004782_abnormal_surfactant_physiolog1.04122836
54MP0002733_abnormal_thermal_nociception1.01201569
55MP0003137_abnormal_impulse_conducting0.97400271
56MP0002184_abnormal_innervation0.96621414
57MP0001986_abnormal_taste_sensitivity0.95183993
58MP0000631_abnormal_neuroendocrine_gland0.94825950
59MP0003786_premature_aging0.94631629
60MP0003136_yellow_coat_color0.93217732
61MP0003195_calcinosis0.93022058
62MP0003890_abnormal_embryonic-extraembry0.92697484
63MP0000358_abnormal_cell_content/0.91301720
64MP0002063_abnormal_learning/memory/cond0.88749172
65MP0006138_congestive_heart_failure0.88204784
66MP0003880_abnormal_central_pattern0.87626669
67MP0003635_abnormal_synaptic_transmissio0.86994535
68MP0001984_abnormal_olfaction0.83128921
69MP0010234_abnormal_vibrissa_follicle0.83031827
70MP0003941_abnormal_skin_development0.82396225
71MP0003693_abnormal_embryo_hatching0.80834669
72MP0001293_anophthalmia0.80541199
73MP0010094_abnormal_chromosome_stability0.79496190
74MP0002837_dystrophic_cardiac_calcinosis0.78112052
75MP0009745_abnormal_behavioral_response0.77336926
76MP0002229_neurodegeneration0.77298180
77MP0001963_abnormal_hearing_physiology0.77253367
78MP0003943_abnormal_hepatobiliary_system0.76717683
79MP0003959_abnormal_lean_body0.76597530
80MP0002752_abnormal_somatic_nervous0.74893918
81MP0002928_abnormal_bile_duct0.74161808
82MP0002098_abnormal_vibrissa_morphology0.73279010
83MP0000465_gastrointestinal_hemorrhage0.72263808
84MP0003698_abnormal_male_reproductive0.71583116
85MP0009046_muscle_twitch0.71301268
86MP0001765_abnormal_ion_homeostasis0.69945775
87MP0001919_abnormal_reproductive_system0.64208412
88MP0000955_abnormal_spinal_cord0.64071027
89MP0002168_other_aberrant_phenotype0.62130648
90MP0002736_abnormal_nociception_after0.61622610
91MP0000049_abnormal_middle_ear0.60706181
92MP0001929_abnormal_gametogenesis0.59938882
93MP0004484_altered_response_of0.59831264
94MP0005379_endocrine/exocrine_gland_phen0.59433012
95MP0001970_abnormal_pain_threshold0.59180765
96MP0002909_abnormal_adrenal_gland0.58145175
97MP0002572_abnormal_emotion/affect_behav0.57147802
98MP0001145_abnormal_male_reproductive0.55977462
99MP0001119_abnormal_female_reproductive0.55408613
100MP0003283_abnormal_digestive_organ0.54834457

Predicted human phenotypes

RankGene SetZ-score
1Generalized aminoaciduria (HP:0002909)9.47670358
2Proximal tubulopathy (HP:0000114)7.71854250
3Pendular nystagmus (HP:0012043)6.85272002
4Severe visual impairment (HP:0001141)6.49118458
5Popliteal pterygium (HP:0009756)4.60681929
6True hermaphroditism (HP:0010459)4.58658193
7Pancreatic fibrosis (HP:0100732)4.58529813
8Absent rod-and cone-mediated responses on ERG (HP:0007688)4.48570915
9Congenital stationary night blindness (HP:0007642)4.47985581
10Pancreatic cysts (HP:0001737)4.30890311
11Abolished electroretinogram (ERG) (HP:0000550)3.80327747
12Attenuation of retinal blood vessels (HP:0007843)3.59536110
13Abnormality of placental membranes (HP:0011409)3.42336423
14Amniotic constriction ring (HP:0009775)3.42336423
15Renal cortical cysts (HP:0000803)3.33502487
16Myokymia (HP:0002411)3.32725259
17Cystic liver disease (HP:0006706)3.27966308
18Genetic anticipation (HP:0003743)3.07481740
19Increased corneal curvature (HP:0100692)2.99901750
20Keratoconus (HP:0000563)2.99901750
21Cystic hygroma (HP:0000476)2.99724893
22Abnormal rod and cone electroretinograms (HP:0008323)2.99067696
23Poikiloderma (HP:0001029)2.93401791
24Aplasia/Hypoplasia of the tongue (HP:0010295)2.89718256
25Acute lymphatic leukemia (HP:0006721)2.87145798
26Abnormality of macular pigmentation (HP:0008002)2.87073381
27Parakeratosis (HP:0001036)2.86539617
28Optic nerve hypoplasia (HP:0000609)2.86344371
29Glycosuria (HP:0003076)2.86207322
30Abnormality of urine glucose concentration (HP:0011016)2.86207322
31Postaxial foot polydactyly (HP:0001830)2.80983221
32Anencephaly (HP:0002323)2.80880400
33Neonatal respiratory distress (HP:0002643)2.78172010
34Sclerocornea (HP:0000647)2.74522229
35Long clavicles (HP:0000890)2.74237277
36Decreased central vision (HP:0007663)2.70140640
37Abnormality of DNA repair (HP:0003254)2.64888661
38Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.58587704
39Congenital hepatic fibrosis (HP:0002612)2.47550459
40Abnormal biliary tract physiology (HP:0012439)2.45415389
41Bile duct proliferation (HP:0001408)2.45415389
42Hypoglycemic coma (HP:0001325)2.45311975
43Agnosia (HP:0010524)2.43492271
44Stenosis of the external auditory canal (HP:0000402)2.42916741
45Fetal akinesia sequence (HP:0001989)2.39965328
46Aplasia of the musculature (HP:0100854)2.34303673
47Chorioretinal atrophy (HP:0000533)2.33727374
48Furrowed tongue (HP:0000221)2.31711285
49Hyperkalemia (HP:0002153)2.30524007
50Abnormality of the renal cortex (HP:0011035)2.29285928
51Nephronophthisis (HP:0000090)2.27828692
52Rib fusion (HP:0000902)2.25765990
53Abnormality of the labia majora (HP:0012881)2.22503345
54Type 2 muscle fiber atrophy (HP:0003554)2.18848945
55Abnormality of homocysteine metabolism (HP:0010919)2.11255173
56Homocystinuria (HP:0002156)2.11255173
57Chronic hepatic failure (HP:0100626)2.11129024
58Abnormality of the renal collecting system (HP:0004742)2.06001020
59Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.05833689
60Preaxial hand polydactyly (HP:0001177)2.05793972
61Entropion (HP:0000621)2.04900447
62Hyperphosphaturia (HP:0003109)2.04703036
63Nausea (HP:0002018)2.01951343
64Degeneration of anterior horn cells (HP:0002398)2.01396395
65Abnormality of the anterior horn cell (HP:0006802)2.01396395
66J-shaped sella turcica (HP:0002680)2.00109870
67Bony spicule pigmentary retinopathy (HP:0007737)2.00039643
68Malignant hyperthermia (HP:0002047)1.99826613
69Decreased circulating renin level (HP:0003351)1.98641969
70Macular degeneration (HP:0000608)1.98244544
71Hypercalciuria (HP:0002150)1.97790547
72Abnormality of the renal medulla (HP:0100957)1.97747127
73Congenital primary aphakia (HP:0007707)1.97612833
74Abnormality of midbrain morphology (HP:0002418)1.96186083
75Molar tooth sign on MRI (HP:0002419)1.96186083
76Gait imbalance (HP:0002141)1.92709571
77Postaxial hand polydactyly (HP:0001162)1.92048529
78Male pseudohermaphroditism (HP:0000037)1.90827563
79Sloping forehead (HP:0000340)1.89731349
80Abnormality of the vitamin B12 metabolism (HP:0004341)1.88293383
81Rickets (HP:0002748)1.85147405
82Nonprogressive disorder (HP:0003680)1.83986817
83Gonadotropin excess (HP:0000837)1.79457036
84Abnormality of vitamin B metabolism (HP:0004340)1.78837799
85Nephrogenic diabetes insipidus (HP:0009806)1.78243847
86Abnormal auditory evoked potentials (HP:0006958)1.78117527
87Median cleft lip (HP:0000161)1.75218397
88Abnormal number of erythroid precursors (HP:0012131)1.72251483
89Muscle fiber atrophy (HP:0100295)1.72109908
90Progressive cerebellar ataxia (HP:0002073)1.71939716
91Constricted visual fields (HP:0001133)1.71581543
92Medial flaring of the eyebrow (HP:0010747)1.71350265
93Vaginal atresia (HP:0000148)1.71130238
943-Methylglutaconic aciduria (HP:0003535)1.67312338
95Genital tract atresia (HP:0001827)1.66535786
96Occipital encephalocele (HP:0002085)1.63617253
97Abnormal urine phosphate concentration (HP:0012599)1.61712783
98Abnormality of methionine metabolism (HP:0010901)1.61346458
99Abnormality of the labia minora (HP:0012880)1.60437053
100Posterior subcapsular cataract (HP:0007787)1.59955145

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.27048486
2CDK195.89678190
3TXK3.51295591
4ADRBK23.20935338
5WNK33.13600494
6FGFR22.69654643
7TRIM282.32920222
8BCKDK2.27562077
9AURKA2.13653211
10MAP4K22.10544725
11BMPR1B1.92063345
12PRKD31.89982809
13RPS6KA41.74628675
14GRK71.69996752
15ACVR1B1.67658238
16BCR1.56277488
17GRK11.54788861
18MAP4K11.41969037
19TNK21.26949541
20MAPK131.20528424
21JAK31.13375662
22MAP3K41.08822916
23PTK2B1.04418112
24CHEK20.99365613
25MKNK20.94941584
26ERBB30.89825939
27STK110.89374513
28MATK0.87880818
29CHEK10.85554365
30MAP2K70.84512638
31NTRK20.83034156
32SIK30.82001767
33PRKACB0.80425662
34TAOK30.79806857
35PLK40.79263087
36TGFBR20.77589034
37TGFBR10.75601643
38CSNK1G30.75387013
39BUB10.73156542
40NUAK10.71630810
41EIF2AK30.71623344
42MAP2K60.70453057
43PRKCG0.69930590
44NTRK30.68413393
45DAPK20.67803577
46CSNK1G10.67608723
47PLK30.67578166
48GRK50.67443057
49INSRR0.67441842
50OXSR10.67299722
51CSNK1G20.66532671
52PLK10.66034560
53KIT0.65108173
54LATS10.64902162
55MAPK80.62876147
56DYRK20.62780684
57PRKCH0.62099042
58MOS0.61391204
59MAPK100.60890133
60CCNB10.60495474
61BTK0.59792138
62SRPK10.59299739
63SYK0.58937205
64PRKG20.57844039
65EGFR0.57428688
66STK30.56997972
67PRKACA0.56812608
68INSR0.54509923
69RPS6KB20.54350358
70PNCK0.52952346
71CSNK1A1L0.52917496
72CSNK1A10.52490315
73LCK0.51539603
74LYN0.51029652
75CDK120.48806376
76PRKCD0.48724748
77PINK10.48298397
78TYRO30.48018120
79STK100.43837268
80MARK10.43158029
81ADRBK10.43111645
82PRKCE0.42999981
83MKNK10.42478665
84CSNK1E0.39000877
85EIF2AK20.38511408
86IGF1R0.38103961
87MAPK40.37908960
88STK390.36476797
89ABL10.36185193
90CAMK2B0.35630957
91OBSCN0.34390321
92CDK10.34006434
93PRKD20.33608974
94RPS6KB10.32924068
95IKBKB0.32832888
96PRKCB0.32699772
97CSNK2A10.32376087
98DYRK1B0.31036942
99NEK60.28640063
100CSNK1D0.28107380

Predicted pathways (KEGG)

RankGene SetZ-score
1Renin-angiotensin system_Homo sapiens_hsa046145.71977053
2Phototransduction_Homo sapiens_hsa047443.92851904
3Taste transduction_Homo sapiens_hsa047423.36197404
4Nicotine addiction_Homo sapiens_hsa050333.04289829
5Pentose and glucuronate interconversions_Homo sapiens_hsa000403.03833561
6Selenocompound metabolism_Homo sapiens_hsa004502.93689019
7Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.45638356
8Homologous recombination_Homo sapiens_hsa034402.35555246
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.35458613
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.15690132
11Retinol metabolism_Homo sapiens_hsa008302.07706518
12Butanoate metabolism_Homo sapiens_hsa006501.97640107
13Steroid hormone biosynthesis_Homo sapiens_hsa001401.94958643
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.76575983
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.74897607
16Starch and sucrose metabolism_Homo sapiens_hsa005001.74141111
17Morphine addiction_Homo sapiens_hsa050321.71004609
18Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.66549038
19Fanconi anemia pathway_Homo sapiens_hsa034601.63417447
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.60764603
21African trypanosomiasis_Homo sapiens_hsa051431.43859056
22Chemical carcinogenesis_Homo sapiens_hsa052041.37802736
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.37016292
24Caffeine metabolism_Homo sapiens_hsa002321.30444640
25GABAergic synapse_Homo sapiens_hsa047271.25608402
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22540817
27Linoleic acid metabolism_Homo sapiens_hsa005911.21649344
28Cocaine addiction_Homo sapiens_hsa050301.17176187
29One carbon pool by folate_Homo sapiens_hsa006701.15871768
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.11185267
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.07066022
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02355688
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.98610532
34Vitamin digestion and absorption_Homo sapiens_hsa049770.97479233
35Circadian rhythm_Homo sapiens_hsa047100.95328011
36Intestinal immune network for IgA production_Homo sapiens_hsa046720.93862715
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93421177
38Calcium signaling pathway_Homo sapiens_hsa040200.92847249
39Glutamatergic synapse_Homo sapiens_hsa047240.92384266
40Circadian entrainment_Homo sapiens_hsa047130.91262722
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90276572
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88936364
43Adipocytokine signaling pathway_Homo sapiens_hsa049200.84485307
44Glycosaminoglycan degradation_Homo sapiens_hsa005310.82659730
45RNA transport_Homo sapiens_hsa030130.82640157
46Serotonergic synapse_Homo sapiens_hsa047260.77948841
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75822138
48Cyanoamino acid metabolism_Homo sapiens_hsa004600.74413165
49Sulfur metabolism_Homo sapiens_hsa009200.74232721
50Asthma_Homo sapiens_hsa053100.73686182
51Ether lipid metabolism_Homo sapiens_hsa005650.70971576
52Propanoate metabolism_Homo sapiens_hsa006400.67394988
53Amphetamine addiction_Homo sapiens_hsa050310.65708441
54Olfactory transduction_Homo sapiens_hsa047400.64718465
55cAMP signaling pathway_Homo sapiens_hsa040240.63102748
56Salivary secretion_Homo sapiens_hsa049700.63055840
57Glycerophospholipid metabolism_Homo sapiens_hsa005640.62670973
58Dopaminergic synapse_Homo sapiens_hsa047280.62204356
59Sphingolipid metabolism_Homo sapiens_hsa006000.61425332
60Basal transcription factors_Homo sapiens_hsa030220.61255941
61ABC transporters_Homo sapiens_hsa020100.60427411
62mRNA surveillance pathway_Homo sapiens_hsa030150.59212339
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58534175
64Arachidonic acid metabolism_Homo sapiens_hsa005900.58401882
65Axon guidance_Homo sapiens_hsa043600.57067339
66Ovarian steroidogenesis_Homo sapiens_hsa049130.56580551
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55637305
68Renin secretion_Homo sapiens_hsa049240.54358539
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51480991
70AMPK signaling pathway_Homo sapiens_hsa041520.51070676
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50936701
72FoxO signaling pathway_Homo sapiens_hsa040680.50230362
73Pyrimidine metabolism_Homo sapiens_hsa002400.49434525
74Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.46076731
75Fatty acid metabolism_Homo sapiens_hsa012120.45645294
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44186039
77Ribosome_Homo sapiens_hsa030100.43520416
78Sulfur relay system_Homo sapiens_hsa041220.43327377
79Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42439984
80Graft-versus-host disease_Homo sapiens_hsa053320.40545415
81Nucleotide excision repair_Homo sapiens_hsa034200.39291693
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39109376
83Nitrogen metabolism_Homo sapiens_hsa009100.39069996
84Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.36871052
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36482221
86Spliceosome_Homo sapiens_hsa030400.35246741
87Type I diabetes mellitus_Homo sapiens_hsa049400.33832829
88Protein digestion and absorption_Homo sapiens_hsa049740.33016805
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.32624836
90Hedgehog signaling pathway_Homo sapiens_hsa043400.30575757
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30326288
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.29687643
93Regulation of autophagy_Homo sapiens_hsa041400.29026054
94Oxytocin signaling pathway_Homo sapiens_hsa049210.28919771
95Autoimmune thyroid disease_Homo sapiens_hsa053200.28917948
96Gap junction_Homo sapiens_hsa045400.28810614
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28424211
98Purine metabolism_Homo sapiens_hsa002300.28125570
99Arginine and proline metabolism_Homo sapiens_hsa003300.27444996
100RNA degradation_Homo sapiens_hsa030180.27198116

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