ZNF345

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.06070151
2fucose catabolic process (GO:0019317)4.54523247
3L-fucose metabolic process (GO:0042354)4.54523247
4L-fucose catabolic process (GO:0042355)4.54523247
5regulation of heat generation (GO:0031650)4.38183802
6cerebral cortex radially oriented cell migration (GO:0021799)3.84196267
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.59411577
8respiratory chain complex IV assembly (GO:0008535)3.57150615
9response to pheromone (GO:0019236)3.54034075
10detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.52392478
11RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.48687942
12response to nerve growth factor (GO:1990089)3.43443010
13cellular response to nerve growth factor stimulus (GO:1990090)3.43443010
14protein localization to endosome (GO:0036010)3.39011173
15preassembly of GPI anchor in ER membrane (GO:0016254)3.35409147
16detection of light stimulus involved in sensory perception (GO:0050962)3.35102448
17detection of light stimulus involved in visual perception (GO:0050908)3.35102448
18regulation of cilium movement (GO:0003352)3.31990534
19regulation of protein glycosylation (GO:0060049)3.31080177
20DNA methylation involved in gamete generation (GO:0043046)3.29002639
21piRNA metabolic process (GO:0034587)3.27539162
22adaptation of signaling pathway (GO:0023058)3.27393629
23positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.25504654
24replication fork processing (GO:0031297)3.22963451
25axoneme assembly (GO:0035082)3.22623938
26protein localization to cilium (GO:0061512)3.22075816
27sphingosine metabolic process (GO:0006670)3.17582913
28indolalkylamine metabolic process (GO:0006586)3.15118088
29cornea development in camera-type eye (GO:0061303)3.12070317
30sphingoid metabolic process (GO:0046519)3.11743098
31protein polyglutamylation (GO:0018095)3.11249641
32establishment of nucleus localization (GO:0040023)3.08468989
33epithelial cilium movement (GO:0003351)3.04689487
34neural tube formation (GO:0001841)3.04252276
35synaptic transmission, cholinergic (GO:0007271)3.02256558
36platelet dense granule organization (GO:0060155)3.00635580
37behavioral response to ethanol (GO:0048149)2.98936678
38cytochrome complex assembly (GO:0017004)2.98556399
39diol metabolic process (GO:0034311)2.98310791
40indole-containing compound catabolic process (GO:0042436)2.98204771
41indolalkylamine catabolic process (GO:0046218)2.98204771
42tryptophan catabolic process (GO:0006569)2.98204771
43head development (GO:0060322)2.93193763
44intracellular lipid transport (GO:0032365)2.92171389
45mannosylation (GO:0097502)2.88579331
46negative regulation of mast cell activation (GO:0033004)2.88566558
47G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.88383082
48nonmotile primary cilium assembly (GO:0035058)2.88148916
49negative regulation of multicellular organism growth (GO:0040015)2.87913944
50photoreceptor cell maintenance (GO:0045494)2.84564754
51establishment of protein localization to Golgi (GO:0072600)2.83240205
52DNA deamination (GO:0045006)2.83196745
53reflex (GO:0060004)2.81876256
54exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.81380252
55nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.78946781
56transmission of nerve impulse (GO:0019226)2.78850000
57kynurenine metabolic process (GO:0070189)2.77418457
58nucleoside diphosphate catabolic process (GO:0009134)2.76506600
59centriole replication (GO:0007099)2.74580844
60gene silencing by RNA (GO:0031047)2.74459065
61positive regulation of cardiac muscle cell differentiation (GO:2000727)2.73630993
62cellular ketone body metabolic process (GO:0046950)2.72904547
63regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.72381699
64negative regulation of DNA-dependent DNA replication (GO:2000104)2.71987716
65atrial cardiac muscle cell action potential (GO:0086014)2.71877074
66cellular response to ATP (GO:0071318)2.68351596
67oxidative phosphorylation (GO:0006119)2.66415807
68microtubule depolymerization (GO:0007019)2.64991125
69C4-dicarboxylate transport (GO:0015740)2.64220670
70cilium morphogenesis (GO:0060271)2.64018349
71negative regulation of telomere maintenance (GO:0032205)2.63433967
72tryptophan metabolic process (GO:0006568)2.62721934
73primary amino compound metabolic process (GO:1901160)2.58583677
74water-soluble vitamin biosynthetic process (GO:0042364)2.56958113
75RNA destabilization (GO:0050779)2.56341419
76presynaptic membrane assembly (GO:0097105)2.56295125
77neuronal action potential (GO:0019228)2.56245916
78sympathetic nervous system development (GO:0048485)2.55856352
79pyrimidine nucleobase catabolic process (GO:0006208)2.55735861
80negative regulation of cytosolic calcium ion concentration (GO:0051481)2.55474025
81regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.55398413
82C-terminal protein amino acid modification (GO:0018410)2.55248242
83C-terminal protein lipidation (GO:0006501)2.53529674
84DNA-dependent DNA replication (GO:0006261)2.53061897
85negative regulation of nucleotide biosynthetic process (GO:0030809)2.51679860
86negative regulation of purine nucleotide biosynthetic process (GO:1900372)2.51679860
87nucleobase catabolic process (GO:0046113)2.50724856
88regulation of action potential (GO:0098900)2.50063596
89cilium movement (GO:0003341)2.49375408
90limb bud formation (GO:0060174)2.49249756
91regulation of energy homeostasis (GO:2000505)2.49180645
92GPI anchor metabolic process (GO:0006505)2.45826582
93protein complex biogenesis (GO:0070271)2.45763174
94mitochondrial respiratory chain complex assembly (GO:0033108)2.45337980
95hindbrain development (GO:0030902)2.45207882
96cilium organization (GO:0044782)2.45029830
97protein import into peroxisome matrix (GO:0016558)2.44537499
98lateral ventricle development (GO:0021670)2.43360570
99mechanosensory behavior (GO:0007638)2.43345429
100NADH dehydrogenase complex assembly (GO:0010257)2.43162421

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.60280651
2ZNF274_21170338_ChIP-Seq_K562_Hela3.23565507
3EZH2_22144423_ChIP-Seq_EOC_Human2.89372278
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.79055325
5VDR_22108803_ChIP-Seq_LS180_Human2.77306696
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.70924635
7IGF1R_20145208_ChIP-Seq_DFB_Human2.61554938
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.59864591
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.54669841
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.49705078
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.40553535
12TAF15_26573619_Chip-Seq_HEK293_Human2.39324611
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.28150098
14EWS_26573619_Chip-Seq_HEK293_Human2.26454203
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.22853012
16P300_19829295_ChIP-Seq_ESCs_Human2.17196606
17FUS_26573619_Chip-Seq_HEK293_Human2.12623356
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.05281353
19ER_23166858_ChIP-Seq_MCF-7_Human2.01734315
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.93994212
21PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.90733199
22PCGF2_27294783_Chip-Seq_NPCs_Mouse1.76027030
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74371985
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.70297219
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.68278573
26STAT3_23295773_ChIP-Seq_U87_Human1.65589351
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64926980
28TP63_19390658_ChIP-ChIP_HaCaT_Human1.64146113
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.63431055
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.62448596
31CBP_20019798_ChIP-Seq_JUKART_Human1.62448596
32MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.62289412
33SUZ12_27294783_Chip-Seq_NPCs_Mouse1.61042922
34BCAT_22108803_ChIP-Seq_LS180_Human1.57978060
35TCF4_23295773_ChIP-Seq_U87_Human1.56383340
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56267572
37SOX2_19829295_ChIP-Seq_ESCs_Human1.54278026
38NANOG_19829295_ChIP-Seq_ESCs_Human1.54278026
39SMAD4_21799915_ChIP-Seq_A2780_Human1.53293174
40NR3C1_21868756_ChIP-Seq_MCF10A_Human1.52145126
41EZH2_27294783_Chip-Seq_NPCs_Mouse1.51582244
42NFE2_27457419_Chip-Seq_LIVER_Mouse1.51349411
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.50771583
44TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50771583
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.49697428
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.45808834
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44098415
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.43436204
49TP53_22573176_ChIP-Seq_HFKS_Human1.40185838
50AR_25329375_ChIP-Seq_VCAP_Human1.39924572
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39814127
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39806536
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37509668
54REST_21632747_ChIP-Seq_MESCs_Mouse1.37197132
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37181880
56PRDM14_20953172_ChIP-Seq_ESCs_Human1.37076430
57CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.36746759
58TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34418509
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.33539872
60TCF4_22108803_ChIP-Seq_LS180_Human1.32736049
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.29458841
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.28596229
63TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.28338231
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.26787825
65NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.25693502
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25064613
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24080511
68P53_22387025_ChIP-Seq_ESCs_Mouse1.23836631
69CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22889395
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22578033
71FLI1_21867929_ChIP-Seq_TH2_Mouse1.21733291
72EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21465613
73ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19062494
74IRF1_19129219_ChIP-ChIP_H3396_Human1.15759770
75CRX_20693478_ChIP-Seq_RETINA_Mouse1.15738109
76RUNX2_22187159_ChIP-Seq_PCA_Human1.14030547
77KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12167716
78MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11709164
79WDR5_24793694_ChIP-Seq_LNCAP_Human1.11470960
80STAT3_18555785_Chip-Seq_ESCs_Mouse1.11454437
81SMAD4_21741376_ChIP-Seq_EPCs_Human1.10782961
82AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10568997
83EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10226983
84AR_21572438_ChIP-Seq_LNCaP_Human1.10060858
85ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09219544
86SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.08366800
87OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08187512
88FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08065736
89MYC_19829295_ChIP-Seq_ESCs_Human1.07112979
90KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05783751
91TP53_16413492_ChIP-PET_HCT116_Human1.05086417
92TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04984399
93E2F1_18555785_Chip-Seq_ESCs_Mouse1.03959824
94RNF2_27304074_Chip-Seq_NSC_Mouse1.03245499
95SOX2_21211035_ChIP-Seq_LN229_Gbm1.02687451
96NCOR_22424771_ChIP-Seq_293T_Human1.02155383
97CMYC_18555785_Chip-Seq_ESCs_Mouse1.02038094
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01532050
99FOXA1_25329375_ChIP-Seq_VCAP_Human1.01295156
100FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01295156

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation3.42108054
2MP0002837_dystrophic_cardiac_calcinosis3.38791485
3MP0002653_abnormal_ependyma_morphology3.03957604
4MP0003195_calcinosis2.94414359
5MP0001984_abnormal_olfaction2.54467693
6MP0001968_abnormal_touch/_nociception2.22573676
7MP0005645_abnormal_hypothalamus_physiol2.22438223
8MP0008877_abnormal_DNA_methylation2.19166887
9MP0000569_abnormal_digit_pigmentation2.18175114
10MP0000427_abnormal_hair_cycle2.12035668
11MP0001986_abnormal_taste_sensitivity2.08942596
12MP0002102_abnormal_ear_morphology2.07549411
13MP0003646_muscle_fatigue2.06073630
14MP0005646_abnormal_pituitary_gland2.03740120
15MP0002876_abnormal_thyroid_physiology1.98939063
16MP0005551_abnormal_eye_electrophysiolog1.93516507
17MP0009745_abnormal_behavioral_response1.92554581
18MP0008875_abnormal_xenobiotic_pharmacok1.90781071
19MP0006292_abnormal_olfactory_placode1.87699906
20MP0009046_muscle_twitch1.80181756
21MP0008872_abnormal_physiological_respon1.79507580
22MP0002272_abnormal_nervous_system1.78031044
23MP0001501_abnormal_sleep_pattern1.75755574
24MP0003136_yellow_coat_color1.74317478
25MP0000631_abnormal_neuroendocrine_gland1.73268960
26MP0002638_abnormal_pupillary_reflex1.69032685
27MP0003880_abnormal_central_pattern1.67766356
28MP0002234_abnormal_pharynx_morphology1.65065773
29MP0001486_abnormal_startle_reflex1.62289960
30MP0002736_abnormal_nociception_after1.61719811
31MP0003787_abnormal_imprinting1.58829420
32MP0005253_abnormal_eye_physiology1.56304033
33MP0006276_abnormal_autonomic_nervous1.54901876
34MP0004885_abnormal_endolymph1.52859724
35MP0001485_abnormal_pinna_reflex1.51532215
36MP0001529_abnormal_vocalization1.43149568
37MP0002064_seizures1.42069961
38MP0002572_abnormal_emotion/affect_behav1.39993831
39MP0006072_abnormal_retinal_apoptosis1.34894848
40MP0004133_heterotaxia1.33294201
41MP0002928_abnormal_bile_duct1.33119873
42MP0005171_absent_coat_pigmentation1.32231093
43MP0002735_abnormal_chemical_nociception1.28386944
44MP0000778_abnormal_nervous_system1.26863251
45MP0002751_abnormal_autonomic_nervous1.26035912
46MP0004924_abnormal_behavior1.23754698
47MP0005386_behavior/neurological_phenoty1.23754698
48MP0002733_abnormal_thermal_nociception1.19743992
49MP0004484_altered_response_of1.18797852
50MP0001970_abnormal_pain_threshold1.17207618
51MP0002822_catalepsy1.16012152
52MP0002063_abnormal_learning/memory/cond1.14083519
53MP0002095_abnormal_skin_pigmentation1.14061203
54MP0008789_abnormal_olfactory_epithelium1.13977326
55MP0002160_abnormal_reproductive_system1.13376247
56MP0004142_abnormal_muscle_tone1.13073342
57MP0005410_abnormal_fertilization1.11985085
58MP0002557_abnormal_social/conspecific_i1.08250239
59MP0000647_abnormal_sebaceous_gland1.08198736
60MP0002734_abnormal_mechanical_nocicepti1.08020853
61MP0010386_abnormal_urinary_bladder1.07769028
62MP0003567_abnormal_fetal_cardiomyocyte1.06678250
63MP0003635_abnormal_synaptic_transmissio1.06288740
64MP0004147_increased_porphyrin_level1.04562481
65MP0003011_delayed_dark_adaptation1.04401119
66MP0002233_abnormal_nose_morphology1.01613156
67MP0003121_genomic_imprinting1.00058345
68MP0002938_white_spotting0.98658359
69MP0002067_abnormal_sensory_capabilities0.98133658
70MP0002184_abnormal_innervation0.96370540
71MP0003890_abnormal_embryonic-extraembry0.95348628
72MP0005389_reproductive_system_phenotype0.93509447
73MP0003045_fibrosis0.92874351
74MP0005187_abnormal_penis_morphology0.91405052
75MP0005084_abnormal_gallbladder_morpholo0.90094770
76MP0003137_abnormal_impulse_conducting0.89606571
77MP0000049_abnormal_middle_ear0.88960169
78MP0008775_abnormal_heart_ventricle0.88478050
79MP0003698_abnormal_male_reproductive0.88304579
80MP0004742_abnormal_vestibular_system0.88251771
81MP0005174_abnormal_tail_pigmentation0.88158929
82MP0000230_abnormal_systemic_arterial0.87439060
83MP0000372_irregular_coat_pigmentation0.86986896
84MP0002138_abnormal_hepatobiliary_system0.83389091
85MP0000613_abnormal_salivary_gland0.82190274
86MP0001929_abnormal_gametogenesis0.81295936
87MP0002168_other_aberrant_phenotype0.77531567
88MP0002693_abnormal_pancreas_physiology0.77522357
89MP0005220_abnormal_exocrine_pancreas0.76849621
90MP0003943_abnormal_hepatobiliary_system0.76809862
91MP0005394_taste/olfaction_phenotype0.75997067
92MP0005499_abnormal_olfactory_system0.75997067
93MP0003718_maternal_effect0.75698186
94MP0004085_abnormal_heartbeat0.74084816
95MP0001905_abnormal_dopamine_level0.73988929
96MP0002909_abnormal_adrenal_gland0.73691760
97MP0005379_endocrine/exocrine_gland_phen0.72880029
98MP0001324_abnormal_eye_pigmentation0.72670341
99MP0002882_abnormal_neuron_morphology0.72514796
100MP0002752_abnormal_somatic_nervous0.71557069

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.40025603
2Broad-based gait (HP:0002136)4.38151980
3Type II lissencephaly (HP:0007260)4.05105831
4Hyperventilation (HP:0002883)3.77429856
5Inability to walk (HP:0002540)3.63424021
6Pancreatic fibrosis (HP:0100732)3.56934034
7Progressive inability to walk (HP:0002505)3.51458701
8True hermaphroditism (HP:0010459)3.40179121
9Molar tooth sign on MRI (HP:0002419)3.32821727
10Abnormality of midbrain morphology (HP:0002418)3.32821727
11Nephronophthisis (HP:0000090)3.31137695
12Abnormality of the renal cortex (HP:0011035)3.25279201
13Focal motor seizures (HP:0011153)3.19240385
14Congenital stationary night blindness (HP:0007642)3.10022124
15Abnormality of the renal medulla (HP:0100957)3.08397779
16Medial flaring of the eyebrow (HP:0010747)3.08221433
17Attenuation of retinal blood vessels (HP:0007843)2.99392359
18Renal cortical cysts (HP:0000803)2.99121777
19Lissencephaly (HP:0001339)2.88636022
20Long nose (HP:0003189)2.87344867
21Conical tooth (HP:0000698)2.83074017
22Fair hair (HP:0002286)2.77546423
23Cystic liver disease (HP:0006706)2.74028642
24Pachygyria (HP:0001302)2.68444527
25Abnormality of the labia minora (HP:0012880)2.61238655
26Abolished electroretinogram (ERG) (HP:0000550)2.55778070
27Calf muscle hypertrophy (HP:0008981)2.54186634
28Retinal dysplasia (HP:0007973)2.52734931
29Gait imbalance (HP:0002141)2.48554406
30Protruding tongue (HP:0010808)2.48478471
31Bulbous nose (HP:0000414)2.47749961
32Widely spaced teeth (HP:0000687)2.44841883
33Pendular nystagmus (HP:0012043)2.43980947
34Chronic hepatic failure (HP:0100626)2.43830782
35Congenital primary aphakia (HP:0007707)2.40743081
36Clumsiness (HP:0002312)2.39722606
37Stomach cancer (HP:0012126)2.38314476
38Dynein arm defect of respiratory motile cilia (HP:0012255)2.38138138
39Absent/shortened dynein arms (HP:0200106)2.38138138
40Reduced antithrombin III activity (HP:0001976)2.36536297
41Absent speech (HP:0001344)2.35075477
42Gaze-evoked nystagmus (HP:0000640)2.33978419
43Neoplasm of the oral cavity (HP:0100649)2.33928110
44Colon cancer (HP:0003003)2.30922704
45Aplasia/Hypoplasia of the uvula (HP:0010293)2.20945010
46Nephrogenic diabetes insipidus (HP:0009806)2.20116528
47Genital tract atresia (HP:0001827)2.19352513
48Muscle hypertrophy of the lower extremities (HP:0008968)2.17914194
49Febrile seizures (HP:0002373)2.16364809
50Abnormality of macular pigmentation (HP:0008002)2.15339211
51Clubbing of toes (HP:0100760)2.14393655
52Amelogenesis imperfecta (HP:0000705)2.12823689
53Exotropia (HP:0000577)2.12643358
54Type I transferrin isoform profile (HP:0003642)2.12583576
55Congenital hepatic fibrosis (HP:0002612)2.12100272
56Vaginal atresia (HP:0000148)2.11934983
57Thyroiditis (HP:0100646)2.07108951
58Neoplasm of the adrenal cortex (HP:0100641)2.04322109
59Focal seizures (HP:0007359)2.00086146
60Sclerocornea (HP:0000647)1.99105933
61Generalized hypopigmentation of hair (HP:0011358)1.98542935
62Polydipsia (HP:0001959)1.97642509
63Abnormal drinking behavior (HP:0030082)1.97642509
64Large for gestational age (HP:0001520)1.97517333
65Abnormal rod and cone electroretinograms (HP:0008323)1.96900166
66Furrowed tongue (HP:0000221)1.96156870
67Dialeptic seizures (HP:0011146)1.93607904
68Abnormal biliary tract physiology (HP:0012439)1.93603384
69Bile duct proliferation (HP:0001408)1.93603384
70Poor coordination (HP:0002370)1.92649335
71Ketoacidosis (HP:0001993)1.92609647
72Decreased electroretinogram (ERG) amplitude (HP:0000654)1.92399204
73Keratoconus (HP:0000563)1.88826575
74Increased corneal curvature (HP:0100692)1.88826575
75Postaxial foot polydactyly (HP:0001830)1.87938322
76Drooling (HP:0002307)1.86333710
77Constricted visual fields (HP:0001133)1.85662750
78Hypothermia (HP:0002045)1.85341780
79Abnormality of the parathyroid morphology (HP:0011766)1.84501218
80Anencephaly (HP:0002323)1.82316882
81Enlarged kidneys (HP:0000105)1.77911406
82Male pseudohermaphroditism (HP:0000037)1.75390805
83Tubular atrophy (HP:0000092)1.74603728
84Polyuria (HP:0000103)1.73998258
85Excessive salivation (HP:0003781)1.73520503
86Abnormal respiratory motile cilium morphology (HP:0005938)1.73050959
87Abnormal respiratory epithelium morphology (HP:0012253)1.73050959
88Postaxial hand polydactyly (HP:0001162)1.72502681
89Small hand (HP:0200055)1.71896048
90Polymicrogyria (HP:0002126)1.71890720
91Abnormal ciliary motility (HP:0012262)1.71479442
92Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.71427955
93Abnormal protein N-linked glycosylation (HP:0012347)1.71427955
94Abnormal protein glycosylation (HP:0012346)1.71427955
95Abnormal glycosylation (HP:0012345)1.71427955
96Severe muscular hypotonia (HP:0006829)1.71160515
97Tubulointerstitial nephritis (HP:0001970)1.71072008
98Decreased central vision (HP:0007663)1.69641726
99Metaphyseal dysplasia (HP:0100255)1.68942875
100Prominent nasal bridge (HP:0000426)1.67943443

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.02120269
2TAOK33.27868977
3ADRBK23.01998567
4PINK12.73327912
5LATS12.67935308
6ZAK2.40351580
7NUAK12.32263172
8BMPR1B2.27407810
9BCR2.25366589
10MAP4K22.11932510
11WNK32.09511583
12GRK12.03607597
13WNK42.02070248
14TNIK1.99785855
15CDK191.95304014
16INSRR1.74665735
17STK38L1.69496887
18CDK31.62764721
19MAPK131.59683904
20CASK1.57021268
21CDC42BPA1.43900557
22ACVR1B1.42560429
23MARK11.41222142
24OXSR11.36308684
25TEC1.29776269
26TXK1.25670399
27DAPK21.23495339
28ADRBK11.22270731
29FGFR21.21466308
30TGFBR21.20836649
31STK31.19625313
32MAP3K41.15508226
33STK391.13571669
34NLK1.11542171
35WNK11.08613928
36SIK21.07327046
37TLK11.03918791
38TRIM280.96193042
39CAMKK20.91633948
40PRKCE0.91081974
41PRKCG0.86117464
42CSNK1A1L0.85819170
43DYRK20.84828945
44NTRK30.84057252
45DYRK30.83718921
46KIT0.81685561
47RPS6KA40.80494244
48PHKG20.75935825
49PHKG10.75935825
50STK380.75876445
51CAMK2A0.75549115
52MAP2K70.74785043
53EIF2AK30.74592557
54TIE10.69989852
55STK110.69856869
56CSNK1G20.67046419
57CSNK1G10.66348038
58ABL10.64242233
59MAP2K60.63857386
60EPHA40.61925352
61HCK0.60574059
62SGK20.60398158
63IKBKB0.60277418
64RPS6KA50.59814235
65CSNK1G30.59683036
66MKNK20.58506769
67PIK3CA0.58121690
68VRK10.58039011
69IKBKE0.57746525
70ITK0.56117050
71PTK2B0.55984838
72NTRK20.54762362
73PRKD30.53663130
74LCK0.53456414
75TGFBR10.52028877
76PAK30.51203901
77MAP2K20.49688248
78PRKAA20.48527881
79ATM0.47457823
80PRKACA0.44948873
81CHUK0.41905310
82BRSK20.41532629
83OBSCN0.40112672
84PRKDC0.39798443
85PLK20.39714641
86MAPK150.39639410
87CAMK40.38784637
88PRKCQ0.37727446
89GRK50.37585313
90CSNK1A10.37067123
91SGK2230.36838237
92SGK4940.36838237
93FLT30.35835140
94PRKCZ0.35781740
95SYK0.34414470
96TNK20.34035866
97MAP3K70.33172115
98CCNB10.32103915
99PLK40.31843669
100PLK30.30940790

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.21342210
2Phototransduction_Homo sapiens_hsa047443.05474678
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.98013072
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.95123737
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.77980686
6Nicotine addiction_Homo sapiens_hsa050332.59494823
7Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.32277235
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.31007289
9Butanoate metabolism_Homo sapiens_hsa006502.27110517
10Regulation of autophagy_Homo sapiens_hsa041402.25015448
11Nitrogen metabolism_Homo sapiens_hsa009102.15670168
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.15581105
13Taste transduction_Homo sapiens_hsa047422.11021977
14Selenocompound metabolism_Homo sapiens_hsa004502.07157688
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.97460016
16Linoleic acid metabolism_Homo sapiens_hsa005911.96799962
17Morphine addiction_Homo sapiens_hsa050321.69477083
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.62859557
19Olfactory transduction_Homo sapiens_hsa047401.59271093
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.59063371
21Fanconi anemia pathway_Homo sapiens_hsa034601.55477964
22Insulin secretion_Homo sapiens_hsa049111.54619592
23Caffeine metabolism_Homo sapiens_hsa002321.54206432
24ABC transporters_Homo sapiens_hsa020101.44582004
25Tryptophan metabolism_Homo sapiens_hsa003801.42858922
26Ether lipid metabolism_Homo sapiens_hsa005651.42373649
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.40541831
28Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.40345870
29Propanoate metabolism_Homo sapiens_hsa006401.37265601
30Glutamatergic synapse_Homo sapiens_hsa047241.33320396
31Non-homologous end-joining_Homo sapiens_hsa034501.32870366
32RNA degradation_Homo sapiens_hsa030181.26704959
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.23295585
34GABAergic synapse_Homo sapiens_hsa047271.21621246
35Homologous recombination_Homo sapiens_hsa034401.21554834
36Circadian entrainment_Homo sapiens_hsa047131.18265653
37Basal transcription factors_Homo sapiens_hsa030221.18254571
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17273505
39Peroxisome_Homo sapiens_hsa041461.16223964
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.11649407
41Protein export_Homo sapiens_hsa030601.10170317
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.06801017
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06168416
44Asthma_Homo sapiens_hsa053101.05852225
45Dorso-ventral axis formation_Homo sapiens_hsa043201.02114979
46Oxidative phosphorylation_Homo sapiens_hsa001901.01082067
47Chemical carcinogenesis_Homo sapiens_hsa052040.99810748
48Type I diabetes mellitus_Homo sapiens_hsa049400.99551745
49Salivary secretion_Homo sapiens_hsa049700.99145469
50RNA polymerase_Homo sapiens_hsa030200.97095932
51Serotonergic synapse_Homo sapiens_hsa047260.92068767
52Calcium signaling pathway_Homo sapiens_hsa040200.89561438
53Retinol metabolism_Homo sapiens_hsa008300.88233339
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88138942
55Dopaminergic synapse_Homo sapiens_hsa047280.82759777
56Ovarian steroidogenesis_Homo sapiens_hsa049130.82516370
57Primary immunodeficiency_Homo sapiens_hsa053400.80460397
58Arachidonic acid metabolism_Homo sapiens_hsa005900.71272553
59beta-Alanine metabolism_Homo sapiens_hsa004100.70352369
60Sphingolipid metabolism_Homo sapiens_hsa006000.70232339
61Purine metabolism_Homo sapiens_hsa002300.70047118
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.68106805
63Renin secretion_Homo sapiens_hsa049240.65608635
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62959496
65Glycerolipid metabolism_Homo sapiens_hsa005610.62658800
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61525589
67Graft-versus-host disease_Homo sapiens_hsa053320.60603785
68Autoimmune thyroid disease_Homo sapiens_hsa053200.58705793
69Parkinsons disease_Homo sapiens_hsa050120.58400180
70N-Glycan biosynthesis_Homo sapiens_hsa005100.57603662
71cAMP signaling pathway_Homo sapiens_hsa040240.55914584
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55041734
73Type II diabetes mellitus_Homo sapiens_hsa049300.54485432
74Allograft rejection_Homo sapiens_hsa053300.53836217
75Fatty acid biosynthesis_Homo sapiens_hsa000610.52344010
76Fat digestion and absorption_Homo sapiens_hsa049750.47229860
77Amphetamine addiction_Homo sapiens_hsa050310.46416103
78One carbon pool by folate_Homo sapiens_hsa006700.45325531
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45002549
80Metabolic pathways_Homo sapiens_hsa011000.43492761
81Histidine metabolism_Homo sapiens_hsa003400.43150238
82Pyrimidine metabolism_Homo sapiens_hsa002400.41543112
83Long-term depression_Homo sapiens_hsa047300.38533763
84Fatty acid degradation_Homo sapiens_hsa000710.38153872
85Cholinergic synapse_Homo sapiens_hsa047250.37743087
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34936404
87Cocaine addiction_Homo sapiens_hsa050300.33526083
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32314862
89Huntingtons disease_Homo sapiens_hsa050160.32000876
90Alzheimers disease_Homo sapiens_hsa050100.31215738
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.30578280
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30137224
93Hematopoietic cell lineage_Homo sapiens_hsa046400.29009599
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.27983553
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.25220971
96Collecting duct acid secretion_Homo sapiens_hsa049660.23355529
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.23106897
98Axon guidance_Homo sapiens_hsa043600.22753500
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.21026215
100Pancreatic secretion_Homo sapiens_hsa049720.20733432

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »