ZNF34

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.41176086
2negative regulation of cytosolic calcium ion concentration (GO:0051481)4.64942475
3nucleobase catabolic process (GO:0046113)4.44409079
4inositol phosphate catabolic process (GO:0071545)4.39530683
5L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.30950102
6phosphorylated carbohydrate dephosphorylation (GO:0046838)4.04615586
7inositol phosphate dephosphorylation (GO:0046855)4.04615586
8behavioral response to ethanol (GO:0048149)4.01532919
9synapsis (GO:0007129)3.90051870
10negative regulation of synaptic transmission, GABAergic (GO:0032229)3.87528398
11nonmotile primary cilium assembly (GO:0035058)3.75579841
12protein complex biogenesis (GO:0070271)3.74882368
13neural tube formation (GO:0001841)3.65339641
14L-methionine salvage (GO:0071267)3.64118772
15L-methionine biosynthetic process (GO:0071265)3.64118772
16amino acid salvage (GO:0043102)3.64118772
17piRNA metabolic process (GO:0034587)3.58433459
18presynaptic membrane organization (GO:0097090)3.46711762
19positive regulation of mitochondrial fission (GO:0090141)3.46570135
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.45550482
21mitochondrial respiratory chain complex I assembly (GO:0032981)3.45550482
22NADH dehydrogenase complex assembly (GO:0010257)3.45550482
23ubiquinone biosynthetic process (GO:0006744)3.41333637
24cytochrome complex assembly (GO:0017004)3.40824411
25regulation of cilium movement (GO:0003352)3.37783948
26adult feeding behavior (GO:0008343)3.37146387
27respiratory chain complex IV assembly (GO:0008535)3.37013578
28presynaptic membrane assembly (GO:0097105)3.35659197
29mitochondrial respiratory chain complex assembly (GO:0033108)3.31312647
30brain morphogenesis (GO:0048854)3.27801393
31cilium morphogenesis (GO:0060271)3.25113024
32cellular ketone body metabolic process (GO:0046950)3.22521670
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.22156146
34retinal cone cell development (GO:0046549)3.14430086
35glycosphingolipid biosynthetic process (GO:0006688)3.13204863
36polyol catabolic process (GO:0046174)3.12994962
37ubiquinone metabolic process (GO:0006743)3.12226666
38proline transport (GO:0015824)3.08972108
39replication fork processing (GO:0031297)3.04165671
40regulation of feeding behavior (GO:0060259)3.02295040
41aggressive behavior (GO:0002118)2.90391383
42resolution of meiotic recombination intermediates (GO:0000712)2.86942533
43neurotransmitter catabolic process (GO:0042135)2.86158841
44ketone body metabolic process (GO:1902224)2.80420560
45gamma-aminobutyric acid transport (GO:0015812)2.76796802
46regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.75057366
47axonal fasciculation (GO:0007413)2.73819699
48regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.71362999
49axoneme assembly (GO:0035082)2.70533272
50protein polyglutamylation (GO:0018095)2.69828252
51DNA methylation involved in gamete generation (GO:0043046)2.69440838
52quinone biosynthetic process (GO:1901663)2.64919794
53acrosome reaction (GO:0007340)2.64571794
54alanine transport (GO:0032328)2.64138808
55water-soluble vitamin biosynthetic process (GO:0042364)2.63716361
56epithelial cilium movement (GO:0003351)2.60801688
57DNA double-strand break processing (GO:0000729)2.59768738
58positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.59115145
59photoreceptor cell maintenance (GO:0045494)2.59078978
60C4-dicarboxylate transport (GO:0015740)2.58959671
61histone H2A acetylation (GO:0043968)2.56014119
62neuron recognition (GO:0008038)2.55756236
63protein-cofactor linkage (GO:0018065)2.55658246
64intraciliary transport (GO:0042073)2.53956373
65negative regulation of cAMP-mediated signaling (GO:0043951)2.53912447
66methionine biosynthetic process (GO:0009086)2.53857667
67somatic diversification of immune receptors via somatic mutation (GO:0002566)2.53792843
68somatic hypermutation of immunoglobulin genes (GO:0016446)2.53792843
69GPI anchor metabolic process (GO:0006505)2.53003944
70C-terminal protein lipidation (GO:0006501)2.52965883
71male meiosis I (GO:0007141)2.50253436
72negative regulation of DNA-dependent DNA replication (GO:2000104)2.48311561
73regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.47934480
74negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.47926856
75glycerophospholipid catabolic process (GO:0046475)2.47631282
76C-terminal protein amino acid modification (GO:0018410)2.46848466
77mannosylation (GO:0097502)2.46699321
78regulation of acyl-CoA biosynthetic process (GO:0050812)2.46667893
79regulation of nuclear cell cycle DNA replication (GO:0033262)2.46195946
80preassembly of GPI anchor in ER membrane (GO:0016254)2.46139602
81neuron cell-cell adhesion (GO:0007158)2.46039885
82regulation of acrosome reaction (GO:0060046)2.41941948
83detection of calcium ion (GO:0005513)2.41712393
84nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.41614281
85establishment of mitochondrion localization (GO:0051654)2.39579625
86inner ear receptor stereocilium organization (GO:0060122)2.39344152
87maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.37083118
88tryptophan catabolic process (GO:0006569)2.36064227
89indole-containing compound catabolic process (GO:0042436)2.36064227
90indolalkylamine catabolic process (GO:0046218)2.36064227
91S-adenosylmethionine metabolic process (GO:0046500)2.34094226
92cilium organization (GO:0044782)2.32852202
93transmission of nerve impulse (GO:0019226)2.32282328
94positive regulation of histone H3-K4 methylation (GO:0051571)2.31051157
95regulation of cofactor metabolic process (GO:0051193)2.30345378
96regulation of coenzyme metabolic process (GO:0051196)2.30345378
97melanosome transport (GO:0032402)2.30034676
98positive regulation of amino acid transport (GO:0051957)2.29510392
99protein localization to cilium (GO:0061512)2.29282558
100glycolipid biosynthetic process (GO:0009247)2.28708037

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.37043195
2ZNF274_21170338_ChIP-Seq_K562_Hela3.62397508
3GBX2_23144817_ChIP-Seq_PC3_Human3.02558679
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.77452623
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.73706338
6TAF15_26573619_Chip-Seq_HEK293_Human2.70757514
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.66695261
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.53058551
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.49494760
10IGF1R_20145208_ChIP-Seq_DFB_Human2.49026054
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.48210403
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.47196961
13FUS_26573619_Chip-Seq_HEK293_Human2.41849717
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.38189129
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.37690040
16EZH2_22144423_ChIP-Seq_EOC_Human2.31333660
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.25301191
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.18812127
19EWS_26573619_Chip-Seq_HEK293_Human2.15629831
20VDR_22108803_ChIP-Seq_LS180_Human2.14541530
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.09007541
22CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03007346
23P300_19829295_ChIP-Seq_ESCs_Human2.02383748
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01598791
25CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00882355
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.76724866
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.70857207
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.59276604
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.58816674
30ELK1_19687146_ChIP-ChIP_HELA_Human1.56586629
31REST_21632747_ChIP-Seq_MESCs_Mouse1.55015615
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53298826
33ER_23166858_ChIP-Seq_MCF-7_Human1.52718507
34MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51483446
35AR_25329375_ChIP-Seq_VCAP_Human1.50397171
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.49704120
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48137809
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47850524
39BCAT_22108803_ChIP-Seq_LS180_Human1.46246938
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45421075
41OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44869012
42VDR_23849224_ChIP-Seq_CD4+_Human1.44350894
43SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43912742
44SMAD4_21799915_ChIP-Seq_A2780_Human1.43601720
45TP53_22573176_ChIP-Seq_HFKS_Human1.43483786
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41608381
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34608377
48RNF2_27304074_Chip-Seq_NSC_Mouse1.34243579
49CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.34193787
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30555892
51CBP_20019798_ChIP-Seq_JUKART_Human1.28734582
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28734582
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.26707315
54ETS1_20019798_ChIP-Seq_JURKAT_Human1.25349665
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25167859
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24058293
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23668257
58TCF4_23295773_ChIP-Seq_U87_Human1.23123849
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.21716105
60* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21330930
61STAT3_23295773_ChIP-Seq_U87_Human1.21108199
62REST_18959480_ChIP-ChIP_MESCs_Mouse1.21106099
63KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20713500
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19487754
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19464227
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18299706
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18299706
68IRF1_19129219_ChIP-ChIP_H3396_Human1.18055958
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17880033
70TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15624083
71HTT_18923047_ChIP-ChIP_STHdh_Human1.14522683
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.14410119
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.13416077
74NANOG_19829295_ChIP-Seq_ESCs_Human1.13368280
75SOX2_19829295_ChIP-Seq_ESCs_Human1.13368280
76* RUNX2_22187159_ChIP-Seq_PCA_Human1.13333007
77FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12997461
78JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.12878376
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.11960001
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09312399
81P53_22387025_ChIP-Seq_ESCs_Mouse1.09214647
82SRF_21415370_ChIP-Seq_HL-1_Mouse1.07964886
83FOXP3_21729870_ChIP-Seq_TREG_Human1.06377852
84NFE2_27457419_Chip-Seq_LIVER_Mouse1.05840020
85BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04101756
86TAL1_26923725_Chip-Seq_HPCs_Mouse1.03044974
87PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02929561
88PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02430223
89PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01422112
90* SOX2_21211035_ChIP-Seq_LN229_Gbm1.01257898
91TCF4_22108803_ChIP-Seq_LS180_Human0.99937485
92EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99400709
93HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98460867
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98329837
95E2F1_18555785_Chip-Seq_ESCs_Mouse0.97273554
96NCOR_22424771_ChIP-Seq_293T_Human0.96698666
97SOX2_16153702_ChIP-ChIP_HESCs_Human0.94858031
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94128132
99TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94062039
100LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93991155

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting3.52656221
2MP0001968_abnormal_touch/_nociception3.23899231
3MP0003880_abnormal_central_pattern2.85093129
4MP0001529_abnormal_vocalization2.77726922
5MP0008877_abnormal_DNA_methylation2.60989906
6MP0002822_catalepsy2.53296614
7MP0002102_abnormal_ear_morphology2.47093022
8MP0001984_abnormal_olfaction2.44535317
9MP0002736_abnormal_nociception_after2.41180091
10MP0005423_abnormal_somatic_nervous2.34079815
11MP0005646_abnormal_pituitary_gland2.23175522
12MP0008789_abnormal_olfactory_epithelium2.19704709
13MP0002735_abnormal_chemical_nociception2.08635901
14MP0004270_analgesia2.02836671
15MP0005645_abnormal_hypothalamus_physiol2.02338008
16MP0009745_abnormal_behavioral_response1.99707945
17MP0005551_abnormal_eye_electrophysiolog1.97582873
18MP0009046_muscle_twitch1.93568672
19MP0002837_dystrophic_cardiac_calcinosis1.91781538
20MP0005499_abnormal_olfactory_system1.88702306
21MP0005394_taste/olfaction_phenotype1.88702306
22MP0006072_abnormal_retinal_apoptosis1.82589478
23MP0006292_abnormal_olfactory_placode1.82451339
24MP0002272_abnormal_nervous_system1.77224975
25MP0006276_abnormal_autonomic_nervous1.75835063
26MP0002572_abnormal_emotion/affect_behav1.73407797
27MP0008058_abnormal_DNA_repair1.72067576
28MP0001986_abnormal_taste_sensitivity1.71845820
29MP0000516_abnormal_urinary_system1.70853427
30MP0005367_renal/urinary_system_phenotyp1.70853427
31MP0002909_abnormal_adrenal_gland1.70615420
32MP0002734_abnormal_mechanical_nocicepti1.67146835
33MP0003635_abnormal_synaptic_transmissio1.65017023
34MP0005253_abnormal_eye_physiology1.58993232
35MP0001905_abnormal_dopamine_level1.58983638
36MP0002733_abnormal_thermal_nociception1.57687750
37MP0002234_abnormal_pharynx_morphology1.57502494
38MP0000778_abnormal_nervous_system1.55461554
39MP0001970_abnormal_pain_threshold1.55185246
40MP0000427_abnormal_hair_cycle1.50901385
41MP0002063_abnormal_learning/memory/cond1.50692595
42MP0002064_seizures1.46901098
43MP0002653_abnormal_ependyma_morphology1.46585165
44MP0002557_abnormal_social/conspecific_i1.46454942
45MP0003718_maternal_effect1.45689477
46MP0001486_abnormal_startle_reflex1.44343528
47MP0004859_abnormal_synaptic_plasticity1.40309891
48MP0006035_abnormal_mitochondrial_morpho1.38949532
49MP0005386_behavior/neurological_phenoty1.38319028
50MP0004924_abnormal_behavior1.38319028
51MP0009780_abnormal_chondrocyte_physiolo1.35957560
52MP0003121_genomic_imprinting1.35602417
53MP0005379_endocrine/exocrine_gland_phen1.34449075
54MP0000631_abnormal_neuroendocrine_gland1.32402650
55MP0002876_abnormal_thyroid_physiology1.28426722
56MP0004142_abnormal_muscle_tone1.25486982
57MP0002067_abnormal_sensory_capabilities1.22125714
58MP0002184_abnormal_innervation1.18942846
59MP0002638_abnormal_pupillary_reflex1.13075641
60MP0005248_abnormal_Harderian_gland1.12400949
61MP0002882_abnormal_neuron_morphology1.09722877
62MP0004147_increased_porphyrin_level1.09369955
63MP0001501_abnormal_sleep_pattern1.07389219
64MP0002069_abnormal_eating/drinking_beha1.06604935
65MP0004811_abnormal_neuron_physiology1.03908401
66MP0004215_abnormal_myocardial_fiber1.00694886
67MP0008872_abnormal_physiological_respon0.99941665
68MP0002752_abnormal_somatic_nervous0.98863880
69MP0002163_abnormal_gland_morphology0.96698090
70MP0000955_abnormal_spinal_cord0.95960454
71MP0004043_abnormal_pH_regulation0.95928047
72MP0003633_abnormal_nervous_system0.94990399
73MP0002229_neurodegeneration0.93167881
74MP0002233_abnormal_nose_morphology0.91922364
75MP0005195_abnormal_posterior_eye0.91837252
76MP0000647_abnormal_sebaceous_gland0.90476569
77MP0001929_abnormal_gametogenesis0.89577490
78MP0004085_abnormal_heartbeat0.88102072
79MP0002751_abnormal_autonomic_nervous0.86835845
80MP0002693_abnormal_pancreas_physiology0.86206820
81MP0003698_abnormal_male_reproductive0.85811067
82MP0003119_abnormal_digestive_system0.84758613
83MP0001299_abnormal_eye_distance/0.84444699
84MP0005410_abnormal_fertilization0.83955422
85MP0003122_maternal_imprinting0.82557005
86MP0003137_abnormal_impulse_conducting0.82340657
87MP0004885_abnormal_endolymph0.81962089
88MP0008875_abnormal_xenobiotic_pharmacok0.81101587
89MP0006036_abnormal_mitochondrial_physio0.80856614
90MP0005174_abnormal_tail_pigmentation0.80692539
91MP0002210_abnormal_sex_determination0.80356207
92MP0002066_abnormal_motor_capabilities/c0.79458243
93MP0001944_abnormal_pancreas_morphology0.77426416
94MP0002928_abnormal_bile_duct0.77160221
95MP0000013_abnormal_adipose_tissue0.75799459
96MP0002152_abnormal_brain_morphology0.73307235
97MP0005084_abnormal_gallbladder_morpholo0.71676690
98MP0001502_abnormal_circadian_rhythm0.71412770
99MP0001919_abnormal_reproductive_system0.70927912
100MP0005389_reproductive_system_phenotype0.70324076

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic fibrosis (HP:0100732)3.66238228
2Intestinal atresia (HP:0011100)3.49684956
3Medial flaring of the eyebrow (HP:0010747)3.46239078
4Colon cancer (HP:0003003)3.41859559
5Pancreatic cysts (HP:0001737)3.39103303
6Gait imbalance (HP:0002141)3.33266504
7Molar tooth sign on MRI (HP:0002419)3.16411870
8Abnormality of midbrain morphology (HP:0002418)3.16411870
9Nephronophthisis (HP:0000090)3.13019902
10Renal cortical cysts (HP:0000803)3.12191291
11Congenital primary aphakia (HP:0007707)3.11191933
12Gaze-evoked nystagmus (HP:0000640)3.09108947
13True hermaphroditism (HP:0010459)3.07065911
14Abnormality of the renal cortex (HP:0011035)3.05672602
15Nephrogenic diabetes insipidus (HP:0009806)2.89409205
16Acute necrotizing encephalopathy (HP:0006965)2.80793214
17Abolished electroretinogram (ERG) (HP:0000550)2.75004890
18Progressive macrocephaly (HP:0004481)2.74491688
19Absent speech (HP:0001344)2.62110694
20Methylmalonic acidemia (HP:0002912)2.61678763
21Abnormality of the renal medulla (HP:0100957)2.57831700
22Hyperventilation (HP:0002883)2.57532561
233-Methylglutaconic aciduria (HP:0003535)2.55513592
24Congenital stationary night blindness (HP:0007642)2.53936605
25Abnormal mitochondria in muscle tissue (HP:0008316)2.50292653
26Thyroid-stimulating hormone excess (HP:0002925)2.48736503
27Hepatic necrosis (HP:0002605)2.48592129
28Pachygyria (HP:0001302)2.47970252
29Mitochondrial inheritance (HP:0001427)2.45697041
30Abnormality of the labia minora (HP:0012880)2.42547400
31Acute encephalopathy (HP:0006846)2.39236832
32Hemiparesis (HP:0001269)2.38962985
33Hypothermia (HP:0002045)2.38457680
34Hepatocellular necrosis (HP:0001404)2.36910382
35Volvulus (HP:0002580)2.36146368
36Attenuation of retinal blood vessels (HP:0007843)2.35473903
37Increased CSF lactate (HP:0002490)2.30901262
38Abnormal biliary tract physiology (HP:0012439)2.30416593
39Bile duct proliferation (HP:0001408)2.30416593
40Pendular nystagmus (HP:0012043)2.29786073
41Lissencephaly (HP:0001339)2.26163505
42Polyphagia (HP:0002591)2.24429378
43Anencephaly (HP:0002323)2.23957795
44Genital tract atresia (HP:0001827)2.22998391
45Ependymoma (HP:0002888)2.22081335
46Type II lissencephaly (HP:0007260)2.20522138
47Tubulointerstitial nephritis (HP:0001970)2.20205175
48Cystic liver disease (HP:0006706)2.17933782
49Decreased testicular size (HP:0008734)2.16179152
50Poor coordination (HP:0002370)2.14290723
51Failure to thrive in infancy (HP:0001531)2.14135211
52Progressive inability to walk (HP:0002505)2.13660008
53Abnormality of the astrocytes (HP:0100707)2.13027073
54Astrocytoma (HP:0009592)2.13027073
55Hypsarrhythmia (HP:0002521)2.11613733
56Aplasia/Hypoplasia of the tongue (HP:0010295)2.10563979
57EEG with generalized epileptiform discharges (HP:0011198)2.06316849
58Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.05452962
59Abnormal protein N-linked glycosylation (HP:0012347)2.05452962
60Abnormal protein glycosylation (HP:0012346)2.05452962
61Abnormal glycosylation (HP:0012345)2.05452962
62Vaginal atresia (HP:0000148)2.03426156
63Generalized aminoaciduria (HP:0002909)2.01546065
64Chorioretinal atrophy (HP:0000533)2.00944896
65Severe muscular hypotonia (HP:0006829)1.99627325
66Methylmalonic aciduria (HP:0012120)1.99424073
67Bony spicule pigmentary retinopathy (HP:0007737)1.99132477
68Cerebral edema (HP:0002181)1.98045356
69Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.97512490
70Decreased activity of mitochondrial respiratory chain (HP:0008972)1.97512490
71Epileptiform EEG discharges (HP:0011182)1.94736493
72Specific learning disability (HP:0001328)1.92513647
73Widely spaced teeth (HP:0000687)1.91690539
74Abnormality of alanine metabolism (HP:0010916)1.90241038
75Hyperalaninemia (HP:0003348)1.90241038
76Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.90241038
77Postaxial hand polydactyly (HP:0001162)1.88906522
78Sclerocornea (HP:0000647)1.88746384
79Broad-based gait (HP:0002136)1.87936769
80Abnormal drinking behavior (HP:0030082)1.87436798
81Polydipsia (HP:0001959)1.87436798
82Hyperglycinemia (HP:0002154)1.86174147
83Focal motor seizures (HP:0011153)1.86096609
84Optic disc pallor (HP:0000543)1.85746744
85Abnormality of vitamin B metabolism (HP:0004340)1.85055793
86Narrow forehead (HP:0000341)1.84325760
87Retinal dysplasia (HP:0007973)1.83612293
88Tongue fasciculations (HP:0001308)1.81608698
89Febrile seizures (HP:0002373)1.80444027
90Inability to walk (HP:0002540)1.79655016
91Furrowed tongue (HP:0000221)1.79539389
92Focal seizures (HP:0007359)1.78731279
93Neoplasm of the adrenal cortex (HP:0100641)1.78413084
94Broad foot (HP:0001769)1.76465875
95Optic nerve hypoplasia (HP:0000609)1.76257973
96Male pseudohermaphroditism (HP:0000037)1.75891272
97Aqueductal stenosis (HP:0002410)1.75737703
98Increased serum lactate (HP:0002151)1.74736146
99Tubular atrophy (HP:0000092)1.74085975
100Large for gestational age (HP:0001520)1.73613723

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.45643885
2CASK4.04892802
3MAP3K43.63537584
4MAP2K73.22765902
5MAP4K23.04896058
6ADRBK22.99956142
7MARK12.93981114
8NUAK12.64926982
9WNK32.43950490
10TRIM282.33509070
11ERBB32.29997825
12BMPR1B2.25597321
13MAPK132.05710474
14INSRR1.66735656
15PNCK1.63353992
16MKNK11.57105341
17CSNK1G31.55448454
18PAK31.51357926
19CSNK1G21.44872332
20CSNK1G11.43646761
21ZAK1.41899466
22BCR1.39978249
23DYRK21.39296345
24PINK11.34530550
25CSNK1A1L1.33007898
26BCKDK1.32416529
27FGFR21.30314429
28PHKG11.29444606
29PHKG21.29444606
30MAP2K41.27640294
31MST41.24421357
32TNK21.21449913
33GRK11.19968226
34MAPKAPK51.17086278
35TAOK31.16323899
36PRKCG1.11574357
37CAMKK21.08555056
38PRKCE1.05685866
39CCNB11.03802279
40DAPK20.97165192
41PTK2B0.94465747
42EPHA40.94457676
43PIM20.93834074
44EPHA30.88400584
45CAMK2A0.82105924
46TAF10.81619899
47MINK10.81556987
48PRKD30.81284897
49ADRBK10.77439521
50PKN10.76899801
51MKNK20.75128624
52OXSR10.74457213
53DYRK30.71834614
54NTRK20.64505805
55DYRK1A0.63959150
56PLK20.63254355
57CDK50.62592391
58EIF2AK20.62148218
59PRKAA10.61613618
60PAK60.61080125
61SIK20.57595954
62CSNK1D0.56644415
63PLK10.52864861
64SRPK10.52105056
65STK30.51679045
66EIF2AK10.51023306
67EIF2AK30.50907072
68PRKCZ0.50715324
69YES10.50572684
70RPS6KA50.50344783
71DAPK10.50043514
72WNK40.49946721
73VRK10.49144121
74STK110.48798572
75UHMK10.48538020
76MAP2K60.48044046
77TSSK60.47020752
78GRK50.46648325
79CAMK2D0.46296006
80TGFBR10.45226696
81BRSK20.44714916
82ROCK10.44379771
83MAP3K120.42315130
84NTRK30.39549820
85PRKACA0.39412526
86BMPR20.39324522
87ATM0.38794660
88PRKG10.38262006
89AKT30.38165443
90CDK90.37142551
91PLK40.36441284
92PRKACB0.36149226
93GRK70.35774947
94TIE10.35266358
95MAP3K50.35118807
96STK390.34983435
97BUB10.34703631
98CSNK1A10.33789527
99PLK30.32763198
100PRKCQ0.32498499

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.33046700
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.07881763
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.92041185
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.71388283
5Protein export_Homo sapiens_hsa030602.65584327
6Butanoate metabolism_Homo sapiens_hsa006502.59473352
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.41554225
8Phototransduction_Homo sapiens_hsa047442.40262556
9Oxidative phosphorylation_Homo sapiens_hsa001902.37262539
10Collecting duct acid secretion_Homo sapiens_hsa049662.27362485
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.13654153
12Nicotine addiction_Homo sapiens_hsa050332.06831935
13RNA polymerase_Homo sapiens_hsa030202.01040803
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.93911627
15Propanoate metabolism_Homo sapiens_hsa006401.90863217
16Parkinsons disease_Homo sapiens_hsa050121.80160168
17Basal transcription factors_Homo sapiens_hsa030221.78605058
18RNA degradation_Homo sapiens_hsa030181.76356567
19Fanconi anemia pathway_Homo sapiens_hsa034601.76066545
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.59111564
21Regulation of autophagy_Homo sapiens_hsa041401.52085428
22Nitrogen metabolism_Homo sapiens_hsa009101.47518962
23Taste transduction_Homo sapiens_hsa047421.47368756
24GABAergic synapse_Homo sapiens_hsa047271.45969509
25Selenocompound metabolism_Homo sapiens_hsa004501.41814838
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.39440917
27Folate biosynthesis_Homo sapiens_hsa007901.37659327
28Fatty acid elongation_Homo sapiens_hsa000621.32027524
29Morphine addiction_Homo sapiens_hsa050321.31560705
30Peroxisome_Homo sapiens_hsa041461.31353477
31Insulin secretion_Homo sapiens_hsa049111.26503196
32Non-homologous end-joining_Homo sapiens_hsa034501.23385533
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.21780242
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21748305
35Synaptic vesicle cycle_Homo sapiens_hsa047211.14400006
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.09532649
37Linoleic acid metabolism_Homo sapiens_hsa005911.08973838
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.07121891
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.04690176
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03570048
41Ether lipid metabolism_Homo sapiens_hsa005651.03052720
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.01996514
43Glutamatergic synapse_Homo sapiens_hsa047241.01895471
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.99942892
45Circadian entrainment_Homo sapiens_hsa047130.99769791
46Dopaminergic synapse_Homo sapiens_hsa047280.98468749
47Sphingolipid metabolism_Homo sapiens_hsa006000.97958845
48Olfactory transduction_Homo sapiens_hsa047400.97788513
49beta-Alanine metabolism_Homo sapiens_hsa004100.95999520
50Huntingtons disease_Homo sapiens_hsa050160.95679238
51Base excision repair_Homo sapiens_hsa034100.95500866
52Circadian rhythm_Homo sapiens_hsa047100.92125657
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.91592597
54Alzheimers disease_Homo sapiens_hsa050100.90757898
55Homologous recombination_Homo sapiens_hsa034400.86017127
56Tryptophan metabolism_Homo sapiens_hsa003800.85817933
57Cardiac muscle contraction_Homo sapiens_hsa042600.83752584
58Sulfur relay system_Homo sapiens_hsa041220.83708389
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.81264793
60Retinol metabolism_Homo sapiens_hsa008300.79430945
61One carbon pool by folate_Homo sapiens_hsa006700.79266707
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76534089
63Serotonergic synapse_Homo sapiens_hsa047260.75862915
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73997974
65Metabolic pathways_Homo sapiens_hsa011000.73858929
66ABC transporters_Homo sapiens_hsa020100.73306049
67Steroid biosynthesis_Homo sapiens_hsa001000.73142765
68Purine metabolism_Homo sapiens_hsa002300.73008933
69Vibrio cholerae infection_Homo sapiens_hsa051100.72436117
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70818820
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70647292
72Long-term depression_Homo sapiens_hsa047300.69992678
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69696777
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69239295
75Proteasome_Homo sapiens_hsa030500.68012007
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67422352
77Cocaine addiction_Homo sapiens_hsa050300.65423849
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62004041
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61983117
80Pyrimidine metabolism_Homo sapiens_hsa002400.59865459
81Amphetamine addiction_Homo sapiens_hsa050310.59839084
82Salivary secretion_Homo sapiens_hsa049700.57002877
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56595774
84Glycerolipid metabolism_Homo sapiens_hsa005610.56552388
85Oocyte meiosis_Homo sapiens_hsa041140.56445921
86Renin secretion_Homo sapiens_hsa049240.53678445
87RNA transport_Homo sapiens_hsa030130.49573236
88Ovarian steroidogenesis_Homo sapiens_hsa049130.46387917
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45953023
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45425533
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45256988
92Calcium signaling pathway_Homo sapiens_hsa040200.44465880
93Fatty acid metabolism_Homo sapiens_hsa012120.40061470
94Caffeine metabolism_Homo sapiens_hsa002320.39922848
95Sulfur metabolism_Homo sapiens_hsa009200.38855183
96Dorso-ventral axis formation_Homo sapiens_hsa043200.37800247
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.36442724
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.34532968
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34112145
100cAMP signaling pathway_Homo sapiens_hsa040240.27766206

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