ZNF337

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a zinc finger domain containing protein. The function of this protein has yet to be determined. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)5.22135454
2postsynaptic membrane organization (GO:0001941)4.58175317
3pyrimidine nucleobase catabolic process (GO:0006208)4.45922171
4neuron cell-cell adhesion (GO:0007158)4.41854989
5neurotransmitter-gated ion channel clustering (GO:0072578)4.35226843
6presynaptic membrane organization (GO:0097090)4.30217327
7neuronal action potential propagation (GO:0019227)3.95573883
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.87551093
9negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.76385383
10negative regulation of translation, ncRNA-mediated (GO:0040033)3.76385383
11regulation of translation, ncRNA-mediated (GO:0045974)3.76385383
12regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.67837848
13phenol-containing compound catabolic process (GO:0019336)3.60298089
14auditory behavior (GO:0031223)3.57576661
15mechanosensory behavior (GO:0007638)3.56764772
16locomotory exploration behavior (GO:0035641)3.52878671
17cell migration in hindbrain (GO:0021535)3.52798379
18ionotropic glutamate receptor signaling pathway (GO:0035235)3.47881061
19histone H3-K4 trimethylation (GO:0080182)3.39568447
20establishment of mitochondrion localization (GO:0051654)3.31364682
21nonmotile primary cilium assembly (GO:0035058)3.31195532
22vocalization behavior (GO:0071625)3.29684730
23nucleobase catabolic process (GO:0046113)3.27225536
24neuronal ion channel clustering (GO:0045161)3.23866975
25regulation of ARF GTPase activity (GO:0032312)3.21670348
26brain morphogenesis (GO:0048854)3.16571472
27positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.16027404
28neuron recognition (GO:0008038)3.13132687
29protein localization to synapse (GO:0035418)3.06589421
30regulation of cilium movement (GO:0003352)3.05932620
31regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.05554912
32glutamate receptor signaling pathway (GO:0007215)3.01091253
33stress granule assembly (GO:0034063)2.96266108
34gamma-aminobutyric acid transport (GO:0015812)2.91623359
35histone H3-K36 demethylation (GO:0070544)2.91618565
36regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.90184929
37L-amino acid import (GO:0043092)2.89566603
38regulation of synaptic vesicle exocytosis (GO:2000300)2.88489489
39fibroblast migration (GO:0010761)2.88483371
40axonal fasciculation (GO:0007413)2.84442376
41epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.83370040
42glutamate secretion (GO:0014047)2.81984180
43positive regulation of dendrite morphogenesis (GO:0050775)2.78521724
44positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.76315251
45regulation of synaptic vesicle transport (GO:1902803)2.76184466
46cerebral cortex radially oriented cell migration (GO:0021799)2.75181833
47exploration behavior (GO:0035640)2.74626865
48negative regulation of neurotransmitter secretion (GO:0046929)2.74414721
49G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.73215359
50positive regulation of dendritic spine morphogenesis (GO:0061003)2.71864419
51synaptic transmission, glutamatergic (GO:0035249)2.70235439
52synapse assembly (GO:0007416)2.69397339
53regulation of glutamate receptor signaling pathway (GO:1900449)2.68499351
54dendrite morphogenesis (GO:0048813)2.66859978
55regulation of microtubule-based movement (GO:0060632)2.66268678
56positive regulation of CREB transcription factor activity (GO:0032793)2.65948189
57central nervous system projection neuron axonogenesis (GO:0021952)2.65712405
58histone H3-K9 demethylation (GO:0033169)2.65349216
59cerebellar Purkinje cell differentiation (GO:0021702)2.64935396
60cilium movement (GO:0003341)2.64576964
61establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.64537636
62mitochondrion transport along microtubule (GO:0047497)2.64537636
63cilium or flagellum-dependent cell motility (GO:0001539)2.63163185
64forebrain neuron differentiation (GO:0021879)2.62454348
65synaptic vesicle maturation (GO:0016188)2.62423613
66synaptic vesicle exocytosis (GO:0016079)2.62286576
67establishment of nucleus localization (GO:0040023)2.59799188
68regulation of respiratory system process (GO:0044065)2.59011330
69regulation of synaptic transmission, glutamatergic (GO:0051966)2.58724961
70histone demethylation (GO:0016577)2.55144507
71epithelial cilium movement (GO:0003351)2.52761748
72regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.51559829
73microtubule nucleation (GO:0007020)2.51454850
74regulation of dendritic spine morphogenesis (GO:0061001)2.50786302
75central nervous system myelination (GO:0022010)2.50346590
76axon ensheathment in central nervous system (GO:0032291)2.50346590
77regulation of short-term neuronal synaptic plasticity (GO:0048172)2.49185852
78histone lysine demethylation (GO:0070076)2.48038240
79peptidyl-lysine trimethylation (GO:0018023)2.45768885
80histone H4-K16 acetylation (GO:0043984)2.45504199
81positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.43652764
82neuromuscular synaptic transmission (GO:0007274)2.43084128
83dendritic spine morphogenesis (GO:0060997)2.42900838
84synaptic vesicle docking involved in exocytosis (GO:0016081)2.42621597
85cerebellar granule cell differentiation (GO:0021707)2.41483756
86response to auditory stimulus (GO:0010996)2.41405689
87negative regulation of adenylate cyclase activity (GO:0007194)2.39734979
88cellular response to leptin stimulus (GO:0044320)2.39561706
89long-term synaptic potentiation (GO:0060291)2.39513482
90hormone catabolic process (GO:0042447)2.39142496
91regulation of collateral sprouting (GO:0048670)2.36838575
92central nervous system neuron axonogenesis (GO:0021955)2.36812353
93protein dealkylation (GO:0008214)2.35159038
94protein demethylation (GO:0006482)2.35159038
95limb bud formation (GO:0060174)2.33525121
96RNA localization (GO:0006403)2.33083790
97dendrite development (GO:0016358)2.30644539
98neuron-neuron synaptic transmission (GO:0007270)2.30498384
99positive regulation of membrane potential (GO:0045838)2.29757287
100heart valve formation (GO:0003188)2.29084450

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.14924531
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.53895940
3AR_21572438_ChIP-Seq_LNCaP_Human3.32957123
4CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.06364164
5GBX2_23144817_ChIP-Seq_PC3_Human2.93485919
6IGF1R_20145208_ChIP-Seq_DFB_Human2.69440584
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.58662641
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.48245721
9SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.21693324
10REST_21632747_ChIP-Seq_MESCs_Mouse1.97402842
11CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96634831
12DROSHA_22980978_ChIP-Seq_HELA_Human1.96583505
13RBPJ_22232070_ChIP-Seq_NCS_Mouse1.95736254
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.90387039
15ZNF274_21170338_ChIP-Seq_K562_Hela1.89699017
16REST_18959480_ChIP-ChIP_MESCs_Mouse1.80075862
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.78439898
18ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73948150
19CBX2_27304074_Chip-Seq_ESCs_Mouse1.73300985
20IKZF1_21737484_ChIP-ChIP_HCT116_Human1.72237790
21PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70654263
22CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.68305578
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.67413168
24JARID2_20064375_ChIP-Seq_MESCs_Mouse1.61586598
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.59470516
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59270210
27SMAD4_21799915_ChIP-Seq_A2780_Human1.58772392
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57471298
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.56885794
30RARB_27405468_Chip-Seq_BRAIN_Mouse1.55296868
31* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54295008
32ER_23166858_ChIP-Seq_MCF-7_Human1.51916748
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.48172234
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.47059384
35AHR_22903824_ChIP-Seq_MCF-7_Human1.47045790
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.45067151
37POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44063992
38TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44063992
39STAT3_23295773_ChIP-Seq_U87_Human1.43097319
40RXR_22108803_ChIP-Seq_LS180_Human1.41976209
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.37669984
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37051591
43SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35867387
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35735271
45EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.35129179
46EZH2_18974828_ChIP-Seq_MESCs_Mouse1.34211662
47RNF2_18974828_ChIP-Seq_MESCs_Mouse1.34211662
48SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.33275627
49ARNT_22903824_ChIP-Seq_MCF-7_Human1.32817477
50TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.31299205
51TP53_16413492_ChIP-PET_HCT116_Human1.31133269
52SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.29493466
53CTNNB1_20460455_ChIP-Seq_HCT116_Human1.29457608
54VDR_22108803_ChIP-Seq_LS180_Human1.25789257
55WDR5_24793694_ChIP-Seq_LNCAP_Human1.24891639
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24161020
57ESR1_20079471_ChIP-ChIP_T-47D_Human1.22576502
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22495735
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21161367
60MTF2_20144788_ChIP-Seq_MESCs_Mouse1.20286919
61CBP_20019798_ChIP-Seq_JUKART_Human1.19623719
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19623719
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.18467230
64TCF4_23295773_ChIP-Seq_U87_Human1.16783578
65* AR_19668381_ChIP-Seq_PC3_Human1.16357256
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15387818
67WT1_19549856_ChIP-ChIP_CCG9911_Human1.14783259
68TAF15_26573619_Chip-Seq_HEK293_Human1.14447536
69SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13649436
70FUS_26573619_Chip-Seq_HEK293_Human1.13068381
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.11115833
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10747927
73RUNX2_22187159_ChIP-Seq_PCA_Human1.10234640
74YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10090174
75SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.09731313
76RNF2_27304074_Chip-Seq_NSC_Mouse1.06514032
77EED_16625203_ChIP-ChIP_MESCs_Mouse1.05935630
78FOXA2_19822575_ChIP-Seq_HepG2_Human1.05424944
79* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04900158
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04875974
81SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04864871
82PKCTHETA_26484144_Chip-Seq_BREAST_Human1.04009665
83PRDM14_20953172_ChIP-Seq_ESCs_Human1.03539568
84WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03392117
85KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03040740
86AR_25329375_ChIP-Seq_VCAP_Human1.02563023
87SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.01963500
88PIAS1_25552417_ChIP-Seq_VCAP_Human1.01809660
89E2F1_17053090_ChIP-ChIP_MCF-7_Human1.00826323
90OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00621770
91RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00145318
92PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99915036
93TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99894993
94BCAT_22108803_ChIP-Seq_LS180_Human0.99892606
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99364314
96STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98985373
97P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96536012
98CIITA_25753668_ChIP-Seq_RAJI_Human0.96411959
99MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.91899207
100STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.91243594

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.16338178
2MP0003880_abnormal_central_pattern3.96280631
3MP0001984_abnormal_olfaction3.83808209
4MP0003635_abnormal_synaptic_transmissio2.67032416
5MP0001968_abnormal_touch/_nociception2.65098186
6MP0001986_abnormal_taste_sensitivity2.65084627
7MP0005499_abnormal_olfactory_system2.60105224
8MP0005394_taste/olfaction_phenotype2.60105224
9MP0002063_abnormal_learning/memory/cond2.51000042
10MP0005423_abnormal_somatic_nervous2.47216117
11MP0004270_analgesia2.33005679
12MP0000778_abnormal_nervous_system2.29688471
13MP0003136_yellow_coat_color2.24611900
14MP0003122_maternal_imprinting2.20342488
15MP0002736_abnormal_nociception_after2.20093187
16MP0002064_seizures2.05387744
17MP0002572_abnormal_emotion/affect_behav1.96973351
18MP0001486_abnormal_startle_reflex1.91332895
19MP0003787_abnormal_imprinting1.90588870
20MP0002272_abnormal_nervous_system1.85076912
21MP0008789_abnormal_olfactory_epithelium1.82829696
22MP0009745_abnormal_behavioral_response1.75535759
23MP0000955_abnormal_spinal_cord1.74679491
24MP0002735_abnormal_chemical_nociception1.66077185
25MP0001502_abnormal_circadian_rhythm1.64826016
26MP0002249_abnormal_larynx_morphology1.63133279
27MP0001501_abnormal_sleep_pattern1.62895328
28MP0001188_hyperpigmentation1.61526492
29MP0006276_abnormal_autonomic_nervous1.58753975
30MP0003868_abnormal_feces_composition1.53209418
31MP0002882_abnormal_neuron_morphology1.51630867
32MP0002184_abnormal_innervation1.51241345
33MP0002653_abnormal_ependyma_morphology1.49050823
34MP0002557_abnormal_social/conspecific_i1.46035517
35MP0003121_genomic_imprinting1.45824898
36MP0002233_abnormal_nose_morphology1.44663152
37MP0004381_abnormal_hair_follicle1.41957409
38MP0004811_abnormal_neuron_physiology1.41954604
39MP0002734_abnormal_mechanical_nocicepti1.40810483
40MP0004924_abnormal_behavior1.39198272
41MP0005386_behavior/neurological_phenoty1.39198272
42MP0003385_abnormal_body_wall1.37592375
43MP0009046_muscle_twitch1.37360239
44MP0005646_abnormal_pituitary_gland1.36988749
45MP0003690_abnormal_glial_cell1.36205016
46MP0002067_abnormal_sensory_capabilities1.35622570
47MP0002638_abnormal_pupillary_reflex1.34552087
48MP0002822_catalepsy1.33653468
49MP0001970_abnormal_pain_threshold1.32244692
50MP0003123_paternal_imprinting1.32214179
51MP0000920_abnormal_myelination1.31661803
52MP0000566_synostosis1.31319776
53MP0002152_abnormal_brain_morphology1.28503899
54MP0001529_abnormal_vocalization1.28178812
55MP0001270_distended_abdomen1.25409469
56MP0003633_abnormal_nervous_system1.25402327
57MP0008569_lethality_at_weaning1.24282349
58MP0005171_absent_coat_pigmentation1.23818452
59MP0001177_atelectasis1.15457949
60MP0000569_abnormal_digit_pigmentation1.13997885
61MP0003631_nervous_system_phenotype1.12413444
62MP0004885_abnormal_endolymph1.09946264
63MP0002752_abnormal_somatic_nervous1.08084152
64MP0002066_abnormal_motor_capabilities/c1.06494359
65MP0003632_abnormal_nervous_system1.05449157
66MP0003861_abnormal_nervous_system1.01908338
67MP0002108_abnormal_muscle_morphology0.99547318
68MP0003755_abnormal_palate_morphology0.99303710
69MP0009780_abnormal_chondrocyte_physiolo0.97903580
70MP0000631_abnormal_neuroendocrine_gland0.97267685
71MP0003634_abnormal_glial_cell0.95781481
72MP0003172_abnormal_lysosome_physiology0.95244523
73MP0003942_abnormal_urinary_system0.94697303
74MP0005551_abnormal_eye_electrophysiolog0.92783616
75MP0003935_abnormal_craniofacial_develop0.92587862
76MP0002733_abnormal_thermal_nociception0.91181492
77MP0002928_abnormal_bile_duct0.91116901
78MP0005248_abnormal_Harderian_gland0.88268234
79MP0005174_abnormal_tail_pigmentation0.87702311
80MP0003890_abnormal_embryonic-extraembry0.86769200
81MP0001299_abnormal_eye_distance/0.86569304
82MP0001943_abnormal_respiration0.85802677
83MP0002229_neurodegeneration0.85412777
84MP0000015_abnormal_ear_pigmentation0.85396005
85MP0000427_abnormal_hair_cycle0.85164413
86MP0001963_abnormal_hearing_physiology0.82857996
87MP0000026_abnormal_inner_ear0.80002616
88MP0002116_abnormal_craniofacial_bone0.79883298
89MP0010770_preweaning_lethality0.79231328
90MP0002082_postnatal_lethality0.79231328
91MP0005409_darkened_coat_color0.78096323
92MP0001849_ear_inflammation0.77423220
93MP0001440_abnormal_grooming_behavior0.76718182
94MP0010769_abnormal_survival0.74713614
95MP0003115_abnormal_respiratory_system0.74017055
96MP0002751_abnormal_autonomic_nervous0.72901823
97MP0010768_mortality/aging0.72176671
98MP0002009_preneoplasia0.70229426
99MP0006072_abnormal_retinal_apoptosis0.69309863
100MP0002127_abnormal_cardiovascular_syste0.69267249

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)4.71511053
2Absent speech (HP:0001344)3.28014832
3Febrile seizures (HP:0002373)3.15543270
4Macroorchidism (HP:0000053)3.08674833
5Hepatoblastoma (HP:0002884)3.04180716
6Chronic hepatic failure (HP:0100626)2.89845270
7Truncal ataxia (HP:0002078)2.83129288
8Atonic seizures (HP:0010819)2.79776297
9Heterotopia (HP:0002282)2.79497512
10Broad-based gait (HP:0002136)2.74897805
11Absent/shortened dynein arms (HP:0200106)2.73113278
12Dynein arm defect of respiratory motile cilia (HP:0012255)2.73113278
13Gait imbalance (HP:0002141)2.70400297
14Vitreoretinal degeneration (HP:0000655)2.61193775
15Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.58282278
16Focal motor seizures (HP:0011153)2.57479580
17Papilledema (HP:0001085)2.52098533
18High anterior hairline (HP:0009890)2.45274771
19Neoplasm of the heart (HP:0100544)2.42278397
20Hemiplegia (HP:0002301)2.40340024
21Tented upper lip vermilion (HP:0010804)2.37159320
22Drooling (HP:0002307)2.37157328
23Abnormal ciliary motility (HP:0012262)2.37074205
24Intellectual disability, severe (HP:0010864)2.36692638
25Alacrima (HP:0000522)2.34768196
26Congenital primary aphakia (HP:0007707)2.34363054
27Focal seizures (HP:0007359)2.33375091
2811 pairs of ribs (HP:0000878)2.32024689
29Excessive salivation (HP:0003781)2.30992261
30Facial hemangioma (HP:0000329)2.30702205
31Epileptic encephalopathy (HP:0200134)2.27938744
32Postural instability (HP:0002172)2.27191325
33Abnormal hair whorl (HP:0010721)2.22018069
34Urinary urgency (HP:0000012)2.19630856
35Poor coordination (HP:0002370)2.16513541
36Ankle clonus (HP:0011448)2.14724128
37Medial flaring of the eyebrow (HP:0010747)2.13653765
38Aplasia/Hypoplasia of the brainstem (HP:0007362)2.12866102
39Hypoplasia of the brainstem (HP:0002365)2.12866102
40Protruding tongue (HP:0010808)2.12238098
41Abnormal respiratory motile cilium morphology (HP:0005938)2.07533170
42Abnormal respiratory epithelium morphology (HP:0012253)2.07533170
43Broad alveolar ridges (HP:0000187)2.06827720
44Nephrogenic diabetes insipidus (HP:0009806)2.05298740
45Abnormal respiratory motile cilium physiology (HP:0012261)2.04950654
46Abnormality of the astrocytes (HP:0100707)2.03935038
47Astrocytoma (HP:0009592)2.03935038
48Megalencephaly (HP:0001355)2.02916623
49Fetal akinesia sequence (HP:0001989)2.00674687
50Decreased lacrimation (HP:0000633)2.00350197
51Blue irides (HP:0000635)1.99389722
52Pachygyria (HP:0001302)1.99351362
53Split foot (HP:0001839)1.98052198
54Oligodactyly (hands) (HP:0001180)1.96183696
55Spastic tetraplegia (HP:0002510)1.94835829
56Retinal dysplasia (HP:0007973)1.94227648
57Asymmetry of the thorax (HP:0001555)1.91471564
58Unsteady gait (HP:0002317)1.91124386
59Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.88859897
60Broad face (HP:0000283)1.87816597
61Polyphagia (HP:0002591)1.86731237
62Cerebral hypomyelination (HP:0006808)1.86358044
63Action tremor (HP:0002345)1.85031202
64Hypoplasia of the corpus callosum (HP:0002079)1.83446763
65Spastic gait (HP:0002064)1.82548242
66Abnormality of the aortic arch (HP:0012303)1.82295633
67Abnormality of the columella (HP:0009929)1.79544596
68Occipital encephalocele (HP:0002085)1.78279066
69Open mouth (HP:0000194)1.78110193
70Absence seizures (HP:0002121)1.77936606
71Vaginal atresia (HP:0000148)1.75110524
72Midline defect of the nose (HP:0004122)1.74741265
73Neonatal respiratory distress (HP:0002643)1.73983216
74Narrow palate (HP:0000189)1.73916250
75Aplasia/Hypoplasia of the lens (HP:0008063)1.73716830
76Genital tract atresia (HP:0001827)1.73704888
77Thick eyebrow (HP:0000574)1.72811335
78Short foot (HP:0001773)1.71639597
79Hypoplastic nipples (HP:0002557)1.71007355
80Hypoplastic iliac wings (HP:0002866)1.70899482
81Supranuclear gaze palsy (HP:0000605)1.70627249
82Hemiparesis (HP:0001269)1.69950889
83Steppage gait (HP:0003376)1.69715224
84Thickened helices (HP:0000391)1.69354619
85Broad palm (HP:0001169)1.68828298
86Progressive cerebellar ataxia (HP:0002073)1.67693910
87Myokymia (HP:0002411)1.66862970
88Bronchomalacia (HP:0002780)1.66729006
89Postaxial hand polydactyly (HP:0001162)1.66482162
90Panhypogammaglobulinemia (HP:0003139)1.66002413
91Exotropia (HP:0000577)1.65775164
92Dialeptic seizures (HP:0011146)1.64638170
93Specific learning disability (HP:0001328)1.64562462
94Abnormality of the pubic bones (HP:0003172)1.64237200
95Neoplasm of the oral cavity (HP:0100649)1.62652043
96Hamartoma (HP:0010566)1.62402501
97Broad nasal tip (HP:0000455)1.61116372
98Lower limb muscle weakness (HP:0007340)1.61051817
99Cutaneous melanoma (HP:0012056)1.59811940
100Capillary hemangiomas (HP:0005306)1.59334685

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.82055499
2PINK12.82106094
3MARK12.73510533
4NTRK22.55879175
5SIK22.51850748
6FRK2.45479244
7WNK32.40690915
8MAP2K72.35976287
9FGFR22.35025394
10EPHA42.00271504
11TNIK1.88633047
12MAPK131.85188893
13MAPK151.84886713
14MAP3K41.79538521
15NTRK31.77587807
16SGK2231.72743425
17SGK4941.72743425
18TYRO31.65762447
19BRD41.59164587
20MARK31.54319597
21SGK21.51826027
22STK381.41507868
23LATS11.29991876
24MAP2K41.28544198
25PAK61.24995375
26CAMK1G1.22196469
27CSNK1A1L1.20443696
28FGFR31.19215006
29CDK31.15957880
30CAMK1D1.15180068
31CAMK41.07807264
32RET1.07237472
33MINK11.07094367
34NLK1.06588872
35SGK31.01922969
36TRIB31.01043639
37AKT30.97734161
38MARK20.97665372
39PKN20.96255882
40CDK50.95592782
41STK38L0.93864667
42MAP3K70.92995618
43MAPK70.90794440
44EPHA30.88556486
45NEK60.86837408
46PAK30.86064626
47ICK0.85953623
48CSNK1G30.81670668
49KSR10.81647118
50RPS6KA20.81581283
51FGFR40.81122550
52PDGFRA0.80903302
53PDGFRB0.80533384
54KSR20.79074439
55MAP2K60.78806253
56NEK20.78261540
57CSNK1G20.78124407
58UHMK10.77679280
59TAOK10.77624864
60PKN10.77586921
61PRKCZ0.76964878
62STK110.76224864
63BCR0.76179222
64CDK120.76056567
65CAMKK10.74937701
66TNK20.74767600
67EEF2K0.73999641
68MAP3K90.72501420
69CSNK1G10.72009480
70PRKD30.70804327
71MAP3K100.70340108
72CAMK10.69617888
73FES0.67664377
74MAP3K60.66567201
75SGK10.66281269
76OBSCN0.61456757
77MAP3K130.60459226
78RPS6KA40.60158839
79MAPK120.59372415
80DYRK20.57672028
81RPS6KB10.55951597
82DYRK1A0.54442352
83MUSK0.52957076
84CDC42BPA0.52490986
85EPHB10.50795439
86ZAP700.50584281
87TAOK30.50422557
88DYRK1B0.48672285
89PRKCG0.47237375
90PRKD10.45603898
91FGR0.45141707
92PRKD20.43671694
93PRKAA10.41598729
94CAMKK20.41411934
95CSNK1D0.41400310
96PNCK0.40419141
97WNK10.40171940
98MAPK80.39418333
99DAPK20.39317618
100MAPKAPK30.38715901

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.47537365
2Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.20426042
3Circadian entrainment_Homo sapiens_hsa047131.99619748
4Glutamatergic synapse_Homo sapiens_hsa047241.92257018
5Amphetamine addiction_Homo sapiens_hsa050311.80926167
6Cocaine addiction_Homo sapiens_hsa050301.75493515
7Dopaminergic synapse_Homo sapiens_hsa047281.69406883
8Endometrial cancer_Homo sapiens_hsa052131.66169628
9GABAergic synapse_Homo sapiens_hsa047271.61075216
10Olfactory transduction_Homo sapiens_hsa047401.60368858
11mTOR signaling pathway_Homo sapiens_hsa041501.59074443
12Circadian rhythm_Homo sapiens_hsa047101.58194489
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.58081232
14Notch signaling pathway_Homo sapiens_hsa043301.57343789
15Long-term potentiation_Homo sapiens_hsa047201.56333982
16Choline metabolism in cancer_Homo sapiens_hsa052311.49383349
17Phosphatidylinositol signaling system_Homo sapiens_hsa040701.46969480
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.37307389
19Estrogen signaling pathway_Homo sapiens_hsa049151.36880047
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.36070145
21Oxytocin signaling pathway_Homo sapiens_hsa049211.35302547
22Gap junction_Homo sapiens_hsa045401.33209735
23Axon guidance_Homo sapiens_hsa043601.32680283
24Renin secretion_Homo sapiens_hsa049241.31246202
25Lysine degradation_Homo sapiens_hsa003101.30907643
26Neurotrophin signaling pathway_Homo sapiens_hsa047221.30796243
27Long-term depression_Homo sapiens_hsa047301.30245847
28Glioma_Homo sapiens_hsa052141.30144346
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.28416939
30Cholinergic synapse_Homo sapiens_hsa047251.28132185
31Morphine addiction_Homo sapiens_hsa050321.23028395
32Thyroid hormone signaling pathway_Homo sapiens_hsa049191.22812187
33Dorso-ventral axis formation_Homo sapiens_hsa043201.22777595
34cAMP signaling pathway_Homo sapiens_hsa040241.21231331
35Colorectal cancer_Homo sapiens_hsa052101.19929469
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.18013907
37Taste transduction_Homo sapiens_hsa047421.17577098
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.16200380
39Non-small cell lung cancer_Homo sapiens_hsa052231.13943463
40Gastric acid secretion_Homo sapiens_hsa049711.09980176
41ErbB signaling pathway_Homo sapiens_hsa040121.08188430
42GnRH signaling pathway_Homo sapiens_hsa049121.07824045
43Insulin secretion_Homo sapiens_hsa049111.07712072
44FoxO signaling pathway_Homo sapiens_hsa040681.06844022
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06030255
46Phospholipase D signaling pathway_Homo sapiens_hsa040721.05984912
47Melanogenesis_Homo sapiens_hsa049161.03400372
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.02959485
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02369397
50cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00717111
51ABC transporters_Homo sapiens_hsa020100.99608509
52Longevity regulating pathway - mammal_Homo sapiens_hsa042110.98435534
53Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95788366
54AMPK signaling pathway_Homo sapiens_hsa041520.90968045
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90466592
56Calcium signaling pathway_Homo sapiens_hsa040200.89897308
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.89461113
58Regulation of autophagy_Homo sapiens_hsa041400.88686337
59Inositol phosphate metabolism_Homo sapiens_hsa005620.82795440
60Glucagon signaling pathway_Homo sapiens_hsa049220.82695433
61Insulin signaling pathway_Homo sapiens_hsa049100.82610783
62Salivary secretion_Homo sapiens_hsa049700.82039226
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81792874
64VEGF signaling pathway_Homo sapiens_hsa043700.78032370
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.74400671
66Type II diabetes mellitus_Homo sapiens_hsa049300.74090676
67Hedgehog signaling pathway_Homo sapiens_hsa043400.72992006
68MAPK signaling pathway_Homo sapiens_hsa040100.72950942
69Prolactin signaling pathway_Homo sapiens_hsa049170.69579332
70Synaptic vesicle cycle_Homo sapiens_hsa047210.66153819
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65114731
72Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65104855
73T cell receptor signaling pathway_Homo sapiens_hsa046600.64138320
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64121008
75Acute myeloid leukemia_Homo sapiens_hsa052210.63942240
76Prostate cancer_Homo sapiens_hsa052150.63857140
77Phototransduction_Homo sapiens_hsa047440.63826610
78Ras signaling pathway_Homo sapiens_hsa040140.61397299
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59994688
80Thyroid hormone synthesis_Homo sapiens_hsa049180.58933705
81Other glycan degradation_Homo sapiens_hsa005110.57703651
82Butanoate metabolism_Homo sapiens_hsa006500.57561037
83Propanoate metabolism_Homo sapiens_hsa006400.56929746
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56592671
85Rap1 signaling pathway_Homo sapiens_hsa040150.55835328
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55638489
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55308034
88Renal cell carcinoma_Homo sapiens_hsa052110.54935383
89Glycosaminoglycan degradation_Homo sapiens_hsa005310.54388264
90Wnt signaling pathway_Homo sapiens_hsa043100.51779964
91Insulin resistance_Homo sapiens_hsa049310.51745324
92Basal cell carcinoma_Homo sapiens_hsa052170.46812558
93Chronic myeloid leukemia_Homo sapiens_hsa052200.46028270
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45048827
95Hepatitis B_Homo sapiens_hsa051610.41819126
96Fatty acid metabolism_Homo sapiens_hsa012120.41791257
97B cell receptor signaling pathway_Homo sapiens_hsa046620.40578615
98Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38495007
99beta-Alanine metabolism_Homo sapiens_hsa004100.37573261
100Pancreatic cancer_Homo sapiens_hsa052120.37386780

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