ZNF330

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.23315801
2proteasome assembly (GO:0043248)4.55508040
3establishment of integrated proviral latency (GO:0075713)4.36827450
4ATP synthesis coupled proton transport (GO:0015986)4.19745890
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.19745890
6ribosome assembly (GO:0042255)4.18835561
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.81329879
8negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.80377891
9rRNA modification (GO:0000154)3.78794197
10regulation of mitochondrial translation (GO:0070129)3.76921166
11oxidative phosphorylation (GO:0006119)3.73585457
12formation of translation preinitiation complex (GO:0001731)3.72081153
13regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.71128075
14ribosomal large subunit biogenesis (GO:0042273)3.68649165
15positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.63361994
16respiratory electron transport chain (GO:0022904)3.60469975
17maturation of 5.8S rRNA (GO:0000460)3.56375358
18establishment of viral latency (GO:0019043)3.55629077
19anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.54379055
20cullin deneddylation (GO:0010388)3.54151421
21mitochondrial respiratory chain complex I assembly (GO:0032981)3.48677641
22NADH dehydrogenase complex assembly (GO:0010257)3.48677641
23mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.48677641
24negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.47883281
25negative regulation of ligase activity (GO:0051352)3.47883281
26electron transport chain (GO:0022900)3.47151227
27DNA ligation (GO:0006266)3.46209491
28mitochondrial respiratory chain complex assembly (GO:0033108)3.46140725
29protein complex biogenesis (GO:0070271)3.45318161
30purine nucleobase biosynthetic process (GO:0009113)3.41279911
31IMP biosynthetic process (GO:0006188)3.38284772
32pseudouridine synthesis (GO:0001522)3.35750278
33transcription elongation from RNA polymerase III promoter (GO:0006385)3.26361665
34termination of RNA polymerase III transcription (GO:0006386)3.26361665
35chaperone-mediated protein transport (GO:0072321)3.24763298
36IMP metabolic process (GO:0046040)3.23778156
37CENP-A containing nucleosome assembly (GO:0034080)3.23437840
38respiratory chain complex IV assembly (GO:0008535)3.20867550
39positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.20684173
40somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.20288043
41isotype switching (GO:0045190)3.20288043
42somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.20288043
43rRNA methylation (GO:0031167)3.19729035
44DNA catabolic process, exonucleolytic (GO:0000738)3.19697875
45mitotic metaphase plate congression (GO:0007080)3.19174569
46DNA strand elongation involved in DNA replication (GO:0006271)3.17094880
47DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.16481852
48protein localization to kinetochore (GO:0034501)3.13778510
49protein deneddylation (GO:0000338)3.13726632
50regulation of cellular amino acid metabolic process (GO:0006521)3.13510637
51intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.10644988
52signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.10644988
53signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.09907121
54signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.09907121
55signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.09907121
56positive regulation of ligase activity (GO:0051351)3.08208657
57synapsis (GO:0007129)3.06556013
58metaphase plate congression (GO:0051310)3.04742874
59DNA strand elongation (GO:0022616)3.04629041
60regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.01375872
61chromatin remodeling at centromere (GO:0031055)3.00915029
62signal transduction involved in DNA damage checkpoint (GO:0072422)2.98456160
63signal transduction involved in DNA integrity checkpoint (GO:0072401)2.98456160
64DNA replication checkpoint (GO:0000076)2.95696593
65rRNA processing (GO:0006364)2.94664612
66telomere maintenance via semi-conservative replication (GO:0032201)2.93971249
67nucleobase biosynthetic process (GO:0046112)2.93390648
68regulation of ubiquitin-protein transferase activity (GO:0051438)2.92782321
69AMP metabolic process (GO:0046033)2.92588092
70signal transduction involved in cell cycle checkpoint (GO:0072395)2.92315939
71positive regulation of histone H3-K4 methylation (GO:0051571)2.92210100
72cytochrome complex assembly (GO:0017004)2.91568284
73tricarboxylic acid cycle (GO:0006099)2.90798854
74cellular component biogenesis (GO:0044085)2.89826339
75tRNA aminoacylation for protein translation (GO:0006418)2.89620714
76establishment of protein localization to mitochondrial membrane (GO:0090151)2.89585132
77histone exchange (GO:0043486)2.86579875
78amino acid activation (GO:0043038)2.85751681
79tRNA aminoacylation (GO:0043039)2.85751681
80protein targeting to mitochondrion (GO:0006626)2.84894200
81exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.84391937
82ribonucleoprotein complex biogenesis (GO:0022613)2.84228818
83protoporphyrinogen IX biosynthetic process (GO:0006782)2.83914733
84regulation of ligase activity (GO:0051340)2.83476127
85histone mRNA metabolic process (GO:0008334)2.83372255
86spliceosomal snRNP assembly (GO:0000387)2.82012651
87nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.81440312
88response to pheromone (GO:0019236)2.80542868
89centriole replication (GO:0007099)2.79991696
90ribosome biogenesis (GO:0042254)2.79062673
91rRNA metabolic process (GO:0016072)2.78796031
92ribosomal small subunit assembly (GO:0000028)2.78625805
93translation (GO:0006412)2.75386474
94transcription from mitochondrial promoter (GO:0006390)2.74739433
95non-recombinational repair (GO:0000726)2.74709471
96double-strand break repair via nonhomologous end joining (GO:0006303)2.74709471
97aerobic respiration (GO:0009060)2.74221624
98DNA double-strand break processing (GO:0000729)2.73658873
99maturation of SSU-rRNA (GO:0030490)2.73402192
100protein localization to chromosome, centromeric region (GO:0071459)2.72498052

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.94743524
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.30065781
3E2F7_22180533_ChIP-Seq_HELA_Human4.15485648
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.11527546
5CREB1_15753290_ChIP-ChIP_HEK293T_Human3.53136264
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.39988006
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.33716366
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.24690972
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.13190418
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.06058332
11ELK1_19687146_ChIP-ChIP_HELA_Human2.89315025
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.81924934
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.80978832
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.77037160
15VDR_23849224_ChIP-Seq_CD4+_Human2.75432090
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.62602428
17PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.60896322
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.58621800
19* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.52268228
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.45687387
21FOXP3_21729870_ChIP-Seq_TREG_Human2.45474107
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.42754399
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.42346121
24SRF_21415370_ChIP-Seq_HL-1_Mouse2.33524035
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.31825793
26FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.27067426
27DCP1A_22483619_ChIP-Seq_HELA_Human2.19063366
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.18631548
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.18451434
30MYC_19079543_ChIP-ChIP_MESCs_Mouse2.13914295
31NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10908953
32PADI4_21655091_ChIP-ChIP_MCF-7_Human2.05605707
33HOXB4_20404135_ChIP-ChIP_EML_Mouse2.05505057
34THAP11_20581084_ChIP-Seq_MESCs_Mouse2.00918233
35E2F1_18555785_ChIP-Seq_MESCs_Mouse2.00521193
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.96857532
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.86778499
38GABP_19822575_ChIP-Seq_HepG2_Human1.85762132
39TTF2_22483619_ChIP-Seq_HELA_Human1.84590709
40KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.76793203
41XRN2_22483619_ChIP-Seq_HELA_Human1.70931955
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69106004
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.65240224
44CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.59734560
45BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.52870698
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.48028702
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46725006
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42886994
49MYC_18940864_ChIP-ChIP_HL60_Human1.41433564
50TFEB_21752829_ChIP-Seq_HELA_Human1.36065256
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.35519262
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28758015
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.28586277
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.28054335
55HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.25943344
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.24844217
57BP1_19119308_ChIP-ChIP_Hs578T_Human1.24480753
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23555795
59PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.21622501
60KDM5A_27292631_Chip-Seq_BREAST_Human1.15553041
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14820241
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.12959419
63CIITA_25753668_ChIP-Seq_RAJI_Human1.12295671
64EWS_26573619_Chip-Seq_HEK293_Human1.11615666
65AR_21909140_ChIP-Seq_LNCAP_Human1.11028295
66CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.10434311
67ELK1_22589737_ChIP-Seq_MCF10A_Human1.09864082
68ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09147007
69ZNF274_21170338_ChIP-Seq_K562_Hela1.08898981
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02828266
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01459233
72E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99939872
73CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99509547
74CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99406466
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.98283315
76FUS_26573619_Chip-Seq_HEK293_Human0.97236638
77POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96913403
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94341538
79GATA4_21415370_ChIP-Seq_HL-1_Mouse0.94296882
80NANOG_18555785_ChIP-Seq_MESCs_Mouse0.93962850
81SOX17_20123909_ChIP-Seq_XEN_Mouse0.92031887
82SALL4_22934838_ChIP-ChIP_CD34+_Human0.91163363
83SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89831275
84RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.86927368
85IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.85858228
86TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83909120
87SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.83070261
88ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.82229012
89HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.82181968
90CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.80437895
91GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79836298
92ELF5_23300383_ChIP-Seq_T47D_Human0.77946121
93HTT_18923047_ChIP-ChIP_STHdh_Human0.76600284
94VDR_22108803_ChIP-Seq_LS180_Human0.75997603
95NANOG_16153702_ChIP-ChIP_HESCs_Human0.75495611
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.71570174
97SPI1_23547873_ChIP-Seq_NB4_Human0.69556932
98FLI1_27457419_Chip-Seq_LIVER_Mouse0.68256053
99IRF1_19129219_ChIP-ChIP_H3396_Human0.67634248
100SALL1_21062744_ChIP-ChIP_HESCs_Human0.66943499

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair4.32249428
2MP0002837_dystrophic_cardiac_calcinosis3.99044349
3MP0003806_abnormal_nucleotide_metabolis3.78092298
4MP0010094_abnormal_chromosome_stability3.56651754
5MP0003693_abnormal_embryo_hatching3.38072353
6MP0008057_abnormal_DNA_replication3.08690317
7MP0003646_muscle_fatigue3.05243036
8MP0004957_abnormal_blastocyst_morpholog2.93307124
9MP0000372_irregular_coat_pigmentation2.89297583
10MP0006036_abnormal_mitochondrial_physio2.78484190
11MP0003077_abnormal_cell_cycle2.66036796
12MP0003718_maternal_effect2.58865666
13MP0003111_abnormal_nucleus_morphology2.55441365
14MP0008007_abnormal_cellular_replicative2.33464849
15MP0003186_abnormal_redox_activity2.30302671
16MP0003786_premature_aging2.24308519
17MP0004147_increased_porphyrin_level2.15603334
18MP0005330_cardiomyopathy2.14086460
19MP0004084_abnormal_cardiac_muscle2.13354705
20MP0000749_muscle_degeneration2.12382745
21MP0004215_abnormal_myocardial_fiber2.01631795
22MP0006035_abnormal_mitochondrial_morpho1.99873073
23MP0008932_abnormal_embryonic_tissue1.98338921
24MP0002269_muscular_atrophy1.88338111
25MP0005410_abnormal_fertilization1.85659340
26MP0004145_abnormal_muscle_electrophysio1.77660372
27MP0009697_abnormal_copulation1.75579872
28MP0004036_abnormal_muscle_relaxation1.73140950
29MP0003221_abnormal_cardiomyocyte_apopto1.70147625
30MP0001853_heart_inflammation1.62985866
31MP0008995_early_reproductive_senescence1.61487426
32MP0005408_hypopigmentation1.57787266
33MP0003656_abnormal_erythrocyte_physiolo1.55382357
34MP0003567_abnormal_fetal_cardiomyocyte1.50400709
35MP0008877_abnormal_DNA_methylation1.48585351
36MP0005266_abnormal_metabolism1.47280462
37MP0000358_abnormal_cell_content/1.41754781
38MP0008789_abnormal_olfactory_epithelium1.40668812
39MP0006072_abnormal_retinal_apoptosis1.37808223
40MP0005075_abnormal_melanosome_morpholog1.36205525
41MP0003195_calcinosis1.35850885
42MP0002127_abnormal_cardiovascular_syste1.31934452
43MP0000751_myopathy1.31837866
44MP0002972_abnormal_cardiac_muscle1.26930377
45MP0001730_embryonic_growth_arrest1.23327724
46MP0001929_abnormal_gametogenesis1.22714142
47MP0004087_abnormal_muscle_fiber1.16821140
48MP0002106_abnormal_muscle_physiology1.16091215
49MP0008775_abnormal_heart_ventricle1.15429023
50MP0000313_abnormal_cell_death1.12962552
51MP0004233_abnormal_muscle_weight1.12595856
52MP0003950_abnormal_plasma_membrane1.11276917
53MP0002090_abnormal_vision1.10524114
54MP0003137_abnormal_impulse_conducting1.10319691
55MP0001727_abnormal_embryo_implantation1.09628575
56MP0005084_abnormal_gallbladder_morpholo1.08107983
57MP0000350_abnormal_cell_proliferation1.05717955
58MP0001764_abnormal_homeostasis1.04651462
59MP0002234_abnormal_pharynx_morphology1.03529231
60MP0001697_abnormal_embryo_size1.01569004
61MP0010307_abnormal_tumor_latency1.00802644
62MP0006054_spinal_hemorrhage0.98554522
63MP0006292_abnormal_olfactory_placode0.97880367
64MP0002332_abnormal_exercise_endurance0.94803480
65MP0005253_abnormal_eye_physiology0.94087328
66MP0002102_abnormal_ear_morphology0.92034359
67MP0005670_abnormal_white_adipose0.91985926
68MP0002210_abnormal_sex_determination0.91876252
69MP0002095_abnormal_skin_pigmentation0.91480845
70MP0001661_extended_life_span0.89327148
71MP0005380_embryogenesis_phenotype0.87963762
72MP0001672_abnormal_embryogenesis/_devel0.87963762
73MP0005385_cardiovascular_system_phenoty0.85910498
74MP0001544_abnormal_cardiovascular_syste0.85910498
75MP0001293_anophthalmia0.85897888
76MP0000747_muscle_weakness0.85237871
77MP0002877_abnormal_melanocyte_morpholog0.84142471
78MP0002019_abnormal_tumor_incidence0.82538701
79MP0005620_abnormal_muscle_contractility0.82364555
80MP0004484_altered_response_of0.81435762
81MP0003984_embryonic_growth_retardation0.80335953
82MP0005369_muscle_phenotype0.80028496
83MP0000343_altered_response_to0.79633932
84MP0004085_abnormal_heartbeat0.79470455
85MP0000653_abnormal_sex_gland0.78276099
86MP0002938_white_spotting0.77435877
87MP0002088_abnormal_embryonic_growth/wei0.77423833
88MP0001145_abnormal_male_reproductive0.76932104
89MP0005332_abnormal_amino_acid0.76596563
90MP0002080_prenatal_lethality0.76539402
91MP0002254_reproductive_system_inflammat0.73259960
92MP0005395_other_phenotype0.72135716
93MP0003698_abnormal_male_reproductive0.71245806
94MP0009785_altered_susceptibility_to0.70872144
95MP0005376_homeostasis/metabolism_phenot0.69989593
96MP0000759_abnormal_skeletal_muscle0.69474514
97MP0002139_abnormal_hepatobiliary_system0.69385774
98MP0010630_abnormal_cardiac_muscle0.68662864
99MP0004510_myositis0.67174244
100MP0001542_abnormal_bone_strength0.65606364

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.37614079
2Abnormal mitochondria in muscle tissue (HP:0008316)4.10144985
3Increased hepatocellular lipid droplets (HP:0006565)4.00928343
4Acute encephalopathy (HP:0006846)3.97196251
5Increased serum pyruvate (HP:0003542)3.82240753
6Increased CSF lactate (HP:0002490)3.70753266
7Mitochondrial inheritance (HP:0001427)3.69206795
8Progressive macrocephaly (HP:0004481)3.66020976
9Abnormality of glycolysis (HP:0004366)3.65887030
10Lipid accumulation in hepatocytes (HP:0006561)3.53955510
11Renal Fanconi syndrome (HP:0001994)3.53333860
12Increased intramyocellular lipid droplets (HP:0012240)3.48929802
13Exercise-induced muscle cramps (HP:0003710)3.43073821
14Methylmalonic acidemia (HP:0002912)3.36755537
15Cerebral edema (HP:0002181)3.23721698
16Hepatic necrosis (HP:0002605)3.15635998
17Exercise intolerance (HP:0003546)3.08822080
18Increased serum lactate (HP:0002151)3.05437673
19Nemaline bodies (HP:0003798)2.98159819
20Lactic acidosis (HP:0003128)2.96070329
21Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.95882596
22Hepatocellular necrosis (HP:0001404)2.93871733
23Abnormality of methionine metabolism (HP:0010901)2.93786694
24Muscle fiber inclusion bodies (HP:0100299)2.91792651
25Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.87068969
26Increased muscle lipid content (HP:0009058)2.79803416
27Aplastic anemia (HP:0001915)2.77772440
28Rhabdomyolysis (HP:0003201)2.71730609
29Myoglobinuria (HP:0002913)2.66123348
30Renal cortical cysts (HP:0000803)2.64348049
31Exertional dyspnea (HP:0002875)2.63324031
32Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.62980662
333-Methylglutaconic aciduria (HP:0003535)2.58017207
34Decreased activity of mitochondrial respiratory chain (HP:0008972)2.56951656
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.56951656
36Methylmalonic aciduria (HP:0012120)2.55306573
37Respiratory failure (HP:0002878)2.54537726
38Progressive muscle weakness (HP:0003323)2.51290460
39Cholecystitis (HP:0001082)2.51256196
40Abnormal gallbladder physiology (HP:0012438)2.51256196
41Degeneration of anterior horn cells (HP:0002398)2.41787467
42Abnormality of the anterior horn cell (HP:0006802)2.41787467
43Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.41440161
44Abnormality of alanine metabolism (HP:0010916)2.41440161
45Hyperalaninemia (HP:0003348)2.41440161
46Abnormality of aspartate family amino acid metabolism (HP:0010899)2.37176813
47Respiratory difficulties (HP:0002880)2.31764323
48Type I transferrin isoform profile (HP:0003642)2.28839593
49Abnormality of renal resorption (HP:0011038)2.28747194
50Abnormality of chromosome stability (HP:0003220)2.28367392
51Hypoglycemic coma (HP:0001325)2.24782749
52Nausea (HP:0002018)2.24716402
53Ragged-red muscle fibers (HP:0003200)2.23890351
54Rimmed vacuoles (HP:0003805)2.21650569
55Meckel diverticulum (HP:0002245)2.18884034
56Hypoplasia of the fovea (HP:0007750)2.18794264
57Aplasia/Hypoplasia of the fovea (HP:0008060)2.18794264
58Palpitations (HP:0001962)2.18754261
59Generalized aminoaciduria (HP:0002909)2.15987009
60Abnormal number of erythroid precursors (HP:0012131)2.14974627
61Abnormality of vitamin B metabolism (HP:0004340)2.14863629
62Multiple enchondromatosis (HP:0005701)2.14344763
63Abnormality of the vitamin B12 metabolism (HP:0004341)2.13662175
64Abnormal spermatogenesis (HP:0008669)2.11016133
65Abnormality of the fovea (HP:0000493)2.10127660
66Progressive external ophthalmoplegia (HP:0000590)2.08710377
67Chromsome breakage (HP:0040012)2.07421358
68Optic disc pallor (HP:0000543)2.05469700
69Abnormality of the ileum (HP:0001549)2.03648118
70Abnormality of cells of the erythroid lineage (HP:0012130)2.03415961
71Abnormality of urine glucose concentration (HP:0011016)2.02311641
72Glycosuria (HP:0003076)2.02311641
73Type 2 muscle fiber atrophy (HP:0003554)2.00455466
74Abnormality of the preputium (HP:0100587)1.99445272
75Reticulocytopenia (HP:0001896)1.99098781
76Pancytopenia (HP:0001876)1.98019151
77Microvesicular hepatic steatosis (HP:0001414)1.97824529
78Dicarboxylic aciduria (HP:0003215)1.96457241
79Abnormality of dicarboxylic acid metabolism (HP:0010995)1.96457241
80Macrocytic anemia (HP:0001972)1.95684805
81EMG: myopathic abnormalities (HP:0003458)1.95079327
82Rhabdomyosarcoma (HP:0002859)1.91767922
83Combined immunodeficiency (HP:0005387)1.90820656
84Chromosomal breakage induced by crosslinking agents (HP:0003221)1.88778842
85Abnormality of serum amino acid levels (HP:0003112)1.88423179
86Abnormality of fatty-acid metabolism (HP:0004359)1.88178386
87Muscle hypertrophy of the lower extremities (HP:0008968)1.88050189
88Lethargy (HP:0001254)1.85865685
89Azoospermia (HP:0000027)1.85392499
90Reduced antithrombin III activity (HP:0001976)1.81199025
91Leukodystrophy (HP:0002415)1.81151747
92Abnormality of placental membranes (HP:0011409)1.80061637
93Amniotic constriction ring (HP:0009775)1.80061637
94Aplasia/Hypoplasia of the uvula (HP:0010293)1.79961127
95CNS demyelination (HP:0007305)1.78087008
96Duodenal stenosis (HP:0100867)1.76706923
97Small intestinal stenosis (HP:0012848)1.76706923
98Calf muscle hypertrophy (HP:0008981)1.76090337
99Muscle fiber atrophy (HP:0100295)1.75885879
100Testicular atrophy (HP:0000029)1.75603855

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST43.62204686
2BUB13.53250631
3NEK13.48167171
4EIF2AK33.30408777
5SRPK13.27247433
6EIF2AK13.10613668
7PLK43.08347252
8PDK22.67464542
9OBSCN2.52621669
10MAP4K22.36630490
11PBK2.35966751
12VRK22.32533165
13TTK2.25819264
14CDC72.04090243
15TSSK61.98147724
16NME21.95996085
17PLK31.85367924
18ERBB31.80517230
19STK161.72196363
20GRK71.66774168
21BRSK21.65964646
22VRK11.60882125
23MKNK11.49278737
24NUAK11.49106325
25STK101.47729488
26NEK21.43646979
27WEE11.34111896
28TNIK1.27265198
29CCNB11.24640741
30MOS1.21493410
31TRIM281.16800992
32PLK11.14389556
33SCYL21.12183951
34STK241.08422418
35BMPR21.06731232
36TXK1.06228079
37TESK21.00471536
38NLK0.99635926
39PHKG10.98396300
40PHKG20.98396300
41TGFBR20.98190579
42EIF2AK20.96252401
43ATR0.95545497
44RPS6KA40.94302058
45NME10.93900539
46BCKDK0.93157422
47ZAK0.91503059
48PIK3CG0.91223018
49PLK20.89966516
50BMPR1B0.87610584
51STK38L0.82086824
52ACVR1B0.79986466
53PASK0.79251822
54DYRK30.79142113
55MYLK0.78326047
56MKNK20.78110550
57AURKB0.75272446
58TRPM70.74917891
59ATM0.69737877
60CHEK10.68619980
61ABL20.67509961
62CSNK2A10.66680673
63KDR0.66253129
64WNK30.65361446
65CSNK2A20.65079090
66CSNK1G10.64310827
67RPS6KB20.60910106
68MAP3K50.59747541
69TGFBR10.56822320
70BRD40.55486179
71CHEK20.54518466
72STK30.52812912
73PIM20.50594157
74BRSK10.48648116
75AURKA0.48209768
76CDK70.44870803
77FLT30.44853719
78CSNK1G30.44416678
79PRKACB0.43749514
80TEC0.43527932
81STK40.42937669
82NEK90.40973147
83IKBKB0.40369478
84MAP3K80.40040494
85NEK60.38033765
86MAP3K120.37720873
87CDK20.36444987
88CSNK1E0.35622519
89CAMKK20.32897081
90CLK10.32034324
91CSNK1G20.31073108
92CDK10.30387900
93ALK0.30106714
94MARK30.29737317
95BRAF0.29459854
96KIT0.29302342
97PAK40.29236731
98RPS6KA50.28388602
99TLK10.25967835
100MUSK0.25433499

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.03915588
2Oxidative phosphorylation_Homo sapiens_hsa001903.15554255
3Mismatch repair_Homo sapiens_hsa034302.91931936
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.89095486
5Parkinsons disease_Homo sapiens_hsa050122.76529459
6Ribosome_Homo sapiens_hsa030102.71748375
7DNA replication_Homo sapiens_hsa030302.68677075
8Non-homologous end-joining_Homo sapiens_hsa034502.55996093
9RNA polymerase_Homo sapiens_hsa030202.46095245
10Protein export_Homo sapiens_hsa030602.44496556
11Spliceosome_Homo sapiens_hsa030402.28042043
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.25312236
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.24782493
14Homologous recombination_Homo sapiens_hsa034402.23546276
15Propanoate metabolism_Homo sapiens_hsa006402.13488978
16RNA transport_Homo sapiens_hsa030132.06827235
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.01180347
18Nucleotide excision repair_Homo sapiens_hsa034201.97385094
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.97236513
20RNA degradation_Homo sapiens_hsa030181.88202908
21Huntingtons disease_Homo sapiens_hsa050161.87716003
22Basal transcription factors_Homo sapiens_hsa030221.84806248
23Base excision repair_Homo sapiens_hsa034101.81652647
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.81258220
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.79884529
26Pyruvate metabolism_Homo sapiens_hsa006201.67540416
27One carbon pool by folate_Homo sapiens_hsa006701.66390269
28Alzheimers disease_Homo sapiens_hsa050101.66199536
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.65298384
30Carbon metabolism_Homo sapiens_hsa012001.54004024
31Fanconi anemia pathway_Homo sapiens_hsa034601.51830504
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.50515644
33Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.48361532
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.46798534
35Pyrimidine metabolism_Homo sapiens_hsa002401.44598008
36Cardiac muscle contraction_Homo sapiens_hsa042601.40651364
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.38838041
38Fatty acid elongation_Homo sapiens_hsa000621.35983633
39Purine metabolism_Homo sapiens_hsa002301.35414025
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.27447556
41Cell cycle_Homo sapiens_hsa041101.24980961
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14377818
43Biosynthesis of amino acids_Homo sapiens_hsa012301.08892536
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.04700645
45Glutathione metabolism_Homo sapiens_hsa004800.99314352
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98039519
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.97340495
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95626940
49Selenocompound metabolism_Homo sapiens_hsa004500.94113013
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92616171
51mRNA surveillance pathway_Homo sapiens_hsa030150.92579393
52Peroxisome_Homo sapiens_hsa041460.86252884
53Folate biosynthesis_Homo sapiens_hsa007900.80755582
54Circadian rhythm_Homo sapiens_hsa047100.80691313
55Legionellosis_Homo sapiens_hsa051340.80360739
56Butanoate metabolism_Homo sapiens_hsa006500.80168245
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79069328
58Antigen processing and presentation_Homo sapiens_hsa046120.75004937
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.74134556
60Steroid biosynthesis_Homo sapiens_hsa001000.73482601
61Metabolic pathways_Homo sapiens_hsa011000.73296004
62Pentose phosphate pathway_Homo sapiens_hsa000300.72955788
63Fatty acid degradation_Homo sapiens_hsa000710.70298392
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67314327
65Oocyte meiosis_Homo sapiens_hsa041140.63825737
66p53 signaling pathway_Homo sapiens_hsa041150.61127374
67Regulation of autophagy_Homo sapiens_hsa041400.58289655
68Arginine and proline metabolism_Homo sapiens_hsa003300.58263986
69Sulfur metabolism_Homo sapiens_hsa009200.56608340
70Fatty acid metabolism_Homo sapiens_hsa012120.54982159
71Epstein-Barr virus infection_Homo sapiens_hsa051690.49469929
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46016496
73Collecting duct acid secretion_Homo sapiens_hsa049660.45490317
74Galactose metabolism_Homo sapiens_hsa000520.43252171
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37089214
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.32033265
77Tyrosine metabolism_Homo sapiens_hsa003500.31539507
78Rheumatoid arthritis_Homo sapiens_hsa053230.30296188
79Fructose and mannose metabolism_Homo sapiens_hsa000510.30196045
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29610305
81Tryptophan metabolism_Homo sapiens_hsa003800.28058525
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27586266
83Herpes simplex infection_Homo sapiens_hsa051680.26160268
84Caffeine metabolism_Homo sapiens_hsa002320.26061411
85beta-Alanine metabolism_Homo sapiens_hsa004100.23422682
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22783335
87Type I diabetes mellitus_Homo sapiens_hsa049400.21699668
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.20107606
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.20047908
90Starch and sucrose metabolism_Homo sapiens_hsa005000.16339382
91Arginine biosynthesis_Homo sapiens_hsa002200.13322158
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.12888386
93Primary immunodeficiency_Homo sapiens_hsa053400.11510693
94Graft-versus-host disease_Homo sapiens_hsa053320.10666865
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.08979487
96Nitrogen metabolism_Homo sapiens_hsa009100.04498319
97Phototransduction_Homo sapiens_hsa047440.04454885
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.02880442
99Phenylalanine metabolism_Homo sapiens_hsa003600.02713357
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.02572097

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