ZNF326

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1replication fork processing (GO:0031297)3.93107443
2negative regulation of DNA-dependent DNA replication (GO:2000104)3.82871739
3centriole replication (GO:0007099)3.73674199
4chromatin remodeling at centromere (GO:0031055)3.53089603
5DNA double-strand break processing (GO:0000729)3.51670288
6mitotic sister chromatid cohesion (GO:0007064)3.49601083
7regulation of DNA endoreduplication (GO:0032875)3.48714108
8negative regulation of translation, ncRNA-mediated (GO:0040033)3.41035167
9regulation of translation, ncRNA-mediated (GO:0045974)3.41035167
10negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.41035167
11CENP-A containing nucleosome assembly (GO:0034080)3.38042856
12regulation of nuclear cell cycle DNA replication (GO:0033262)3.31381433
13kinetochore organization (GO:0051383)3.29840170
14maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.26878841
15resolution of meiotic recombination intermediates (GO:0000712)3.13782935
16histone exchange (GO:0043486)3.10328613
17kinetochore assembly (GO:0051382)3.09888461
18regulation of centriole replication (GO:0046599)3.04445544
19establishment of protein localization to mitochondrial membrane (GO:0090151)3.00366011
20monoubiquitinated protein deubiquitination (GO:0035520)2.99490604
21prenylation (GO:0097354)2.96956968
22protein prenylation (GO:0018342)2.96956968
23positive regulation of histone H3-K4 methylation (GO:0051571)2.94818004
24recombinational repair (GO:0000725)2.93531939
25double-strand break repair via homologous recombination (GO:0000724)2.91374577
26limb bud formation (GO:0060174)2.90705146
27neural tube formation (GO:0001841)2.90462116
28somite development (GO:0061053)2.87673521
29DNA replication checkpoint (GO:0000076)2.86997977
30response to pheromone (GO:0019236)2.83051523
31RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.75817091
32exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.74845274
33reciprocal DNA recombination (GO:0035825)2.74416904
34reciprocal meiotic recombination (GO:0007131)2.74416904
35regulation of mitotic spindle checkpoint (GO:1903504)2.74265439
36regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.74265439
37epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.73913120
38regulation of centrosome cycle (GO:0046605)2.73551871
39respiratory chain complex IV assembly (GO:0008535)2.72620717
40regulation of centrosome duplication (GO:0010824)2.71782495
41DNA damage response, detection of DNA damage (GO:0042769)2.70995466
42intraciliary transport (GO:0042073)2.70708603
43DNA replication-independent nucleosome assembly (GO:0006336)2.70219351
44DNA replication-independent nucleosome organization (GO:0034724)2.70219351
45regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.69412199
46nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.68374955
47behavioral response to ethanol (GO:0048149)2.64992716
48non-recombinational repair (GO:0000726)2.64025574
49double-strand break repair via nonhomologous end joining (GO:0006303)2.64025574
50regulation of helicase activity (GO:0051095)2.63674387
51centrosome organization (GO:0051297)2.62768879
52histone H2A acetylation (GO:0043968)2.59977006
53hindbrain development (GO:0030902)2.59963352
54sister chromatid cohesion (GO:0007062)2.56863086
55negative regulation of DNA recombination (GO:0045910)2.56799758
56regulation of non-canonical Wnt signaling pathway (GO:2000050)2.56022487
57microtubule organizing center organization (GO:0031023)2.54889482
58positive regulation of mRNA processing (GO:0050685)2.53454794
59presynaptic membrane assembly (GO:0097105)2.52857670
60regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.52274488
61ncRNA catabolic process (GO:0034661)2.49717510
62histone H3-K4 trimethylation (GO:0080182)2.48575839
63regulation of mRNA splicing, via spliceosome (GO:0048024)2.48086419
64postreplication repair (GO:0006301)2.46097843
65mRNA splice site selection (GO:0006376)2.43837704
66microtubule anchoring (GO:0034453)2.41404773
67pre-miRNA processing (GO:0031054)2.41301101
68somatic hypermutation of immunoglobulin genes (GO:0016446)2.39072913
69somatic diversification of immune receptors via somatic mutation (GO:0002566)2.39072913
70intra-S DNA damage checkpoint (GO:0031573)2.38689305
71detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.38115283
72DNA topological change (GO:0006265)2.37940296
73sister chromatid segregation (GO:0000819)2.37139899
74kidney morphogenesis (GO:0060993)2.37048557
75meiotic chromosome segregation (GO:0045132)2.36962636
76nonmotile primary cilium assembly (GO:0035058)2.36370555
77DNA ligation (GO:0006266)2.35365247
78positive regulation of RNA splicing (GO:0033120)2.34572777
79regulation of telomere maintenance (GO:0032204)2.31112614
80spindle checkpoint (GO:0031577)2.30261083
81cytochrome complex assembly (GO:0017004)2.29749426
82DNA catabolic process, exonucleolytic (GO:0000738)2.29296829
83cilium organization (GO:0044782)2.29072056
84organelle disassembly (GO:1903008)2.28148804
85presynaptic membrane organization (GO:0097090)2.27010388
86otic vesicle formation (GO:0030916)2.25741307
87behavioral response to nicotine (GO:0035095)2.25600476
88transcription elongation from RNA polymerase I promoter (GO:0006362)2.25463587
89cilium assembly (GO:0042384)2.25459407
90peptidyl-lysine trimethylation (GO:0018023)2.25014374
91mitochondrial respiratory chain complex assembly (GO:0033108)2.24849034
92response to X-ray (GO:0010165)2.24699664
93nuclear pore complex assembly (GO:0051292)2.24392822
94DNA recombination (GO:0006310)2.23855750
95protein complex biogenesis (GO:0070271)2.23853211
96centriole assembly (GO:0098534)2.23461650
97positive regulation of mRNA metabolic process (GO:1903313)2.23342206
98negative regulation of transcription regulatory region DNA binding (GO:2000678)2.23135025
99mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.23087821
100NADH dehydrogenase complex assembly (GO:0010257)2.23087821

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human3.34234435
2FUS_26573619_Chip-Seq_HEK293_Human2.84797865
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.84788251
4ZNF274_21170338_ChIP-Seq_K562_Hela2.76457879
5EWS_26573619_Chip-Seq_HEK293_Human2.69832907
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.68050821
7E2F7_22180533_ChIP-Seq_HELA_Human2.67836146
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.63084135
9VDR_22108803_ChIP-Seq_LS180_Human2.62273157
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.62248406
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.57204551
12IGF1R_20145208_ChIP-Seq_DFB_Human2.52027458
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.51997479
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.39471126
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.30252564
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.28461559
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.25825341
18GBX2_23144817_ChIP-Seq_PC3_Human2.24771171
19TAF15_26573619_Chip-Seq_HEK293_Human2.22862367
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.15931210
21ELK1_19687146_ChIP-ChIP_HELA_Human2.13453309
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.08426012
23RBPJ_22232070_ChIP-Seq_NCS_Mouse2.07612808
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.05860432
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.04815081
26P300_19829295_ChIP-Seq_ESCs_Human1.99927631
27TP63_19390658_ChIP-ChIP_HaCaT_Human1.89870112
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.86323551
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75285218
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65602789
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62419532
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58280338
33POU5F1_16153702_ChIP-ChIP_HESCs_Human1.57970001
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.56386274
35MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53468831
36MYC_18940864_ChIP-ChIP_HL60_Human1.46064385
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45757772
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.45666710
39ER_23166858_ChIP-Seq_MCF-7_Human1.45207308
40VDR_23849224_ChIP-Seq_CD4+_Human1.43355153
41POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42832228
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42832228
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41962478
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39513183
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38332397
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37222200
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36826068
48FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.32434336
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.31993492
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.31492706
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30641996
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.30501373
53SMAD4_21799915_ChIP-Seq_A2780_Human1.29854601
54* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29744197
55CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.28711674
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27292726
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26751785
58* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26625515
59* CBP_20019798_ChIP-Seq_JUKART_Human1.26625515
60STAT3_23295773_ChIP-Seq_U87_Human1.26257384
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23980489
62BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23330409
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.23049188
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22884547
65BCAT_22108803_ChIP-Seq_LS180_Human1.22638371
66TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21728445
67RNF2_27304074_Chip-Seq_NSC_Mouse1.21296744
68NANOG_18555785_Chip-Seq_ESCs_Mouse1.20799494
69RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20703450
70CBX2_27304074_Chip-Seq_ESCs_Mouse1.18969360
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18649781
72PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15806657
73TCF4_22108803_ChIP-Seq_LS180_Human1.14821489
74ETS1_20019798_ChIP-Seq_JURKAT_Human1.14175267
75AR_25329375_ChIP-Seq_VCAP_Human1.13842774
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13084915
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11259252
78EZH2_22144423_ChIP-Seq_EOC_Human1.11175628
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.11100310
80TCF4_23295773_ChIP-Seq_U87_Human1.10974954
81CREB1_15753290_ChIP-ChIP_HEK293T_Human1.10944077
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.10868971
83FOXP3_21729870_ChIP-Seq_TREG_Human1.09877379
84SOX2_16153702_ChIP-ChIP_HESCs_Human1.08765275
85E2F1_18555785_Chip-Seq_ESCs_Mouse1.06429692
86IRF1_19129219_ChIP-ChIP_H3396_Human1.06211166
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05561068
88SOX2_19829295_ChIP-Seq_ESCs_Human1.05157608
89NANOG_19829295_ChIP-Seq_ESCs_Human1.05157608
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02583171
91TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02041638
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01153223
93P53_22387025_ChIP-Seq_ESCs_Mouse1.01144250
94RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00114361
95RUNX2_22187159_ChIP-Seq_PCA_Human0.99737977
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99126914
97SOX9_26525672_Chip-Seq_HEART_Mouse0.98498851
98STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.96805005
99SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96520192
100BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96296478

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.98817836
2MP0008877_abnormal_DNA_methylation2.80174862
3MP0003890_abnormal_embryonic-extraembry2.65446432
4MP0008058_abnormal_DNA_repair2.62982749
5MP0006292_abnormal_olfactory_placode2.61552574
6MP0010094_abnormal_chromosome_stability2.46714794
7MP0000569_abnormal_digit_pigmentation2.43761997
8MP0003136_yellow_coat_color2.35182750
9MP0002938_white_spotting2.19098903
10MP0003787_abnormal_imprinting2.12633009
11MP0002102_abnormal_ear_morphology2.01237192
12MP0005187_abnormal_penis_morphology1.79796551
13MP0003121_genomic_imprinting1.76329305
14MP0001293_anophthalmia1.75443026
15MP0003880_abnormal_central_pattern1.75395126
16MP0004133_heterotaxia1.72927023
17MP0008995_early_reproductive_senescence1.66990179
18MP0003937_abnormal_limbs/digits/tail_de1.66825661
19MP0001188_hyperpigmentation1.64861024
20MP0003111_abnormal_nucleus_morphology1.59621962
21MP0000631_abnormal_neuroendocrine_gland1.59309928
22MP0003077_abnormal_cell_cycle1.57296377
23MP0003693_abnormal_embryo_hatching1.56794967
24MP0000372_irregular_coat_pigmentation1.50943393
25MP0004957_abnormal_blastocyst_morpholog1.49765818
26MP0002234_abnormal_pharynx_morphology1.47757448
27MP0002638_abnormal_pupillary_reflex1.46478718
28MP0003718_maternal_effect1.45746053
29MP0003195_calcinosis1.45207566
30MP0000778_abnormal_nervous_system1.43072184
31MP0001529_abnormal_vocalization1.42808784
32MP0002233_abnormal_nose_morphology1.41941269
33MP0005646_abnormal_pituitary_gland1.38105572
34MP0006072_abnormal_retinal_apoptosis1.35938417
35MP0005551_abnormal_eye_electrophysiolog1.33395467
36MP0003119_abnormal_digestive_system1.32693193
37MP0008007_abnormal_cellular_replicative1.32638710
38MP0003567_abnormal_fetal_cardiomyocyte1.31993653
39MP0001286_abnormal_eye_development1.30942303
40MP0003122_maternal_imprinting1.30941547
41MP0005253_abnormal_eye_physiology1.25411297
42MP0001984_abnormal_olfaction1.21972018
43MP0002751_abnormal_autonomic_nervous1.17231311
44MP0005171_absent_coat_pigmentation1.16330514
45MP0008932_abnormal_embryonic_tissue1.13579676
46MP0006276_abnormal_autonomic_nervous1.12055003
47MP0000647_abnormal_sebaceous_gland1.08994759
48MP0001485_abnormal_pinna_reflex1.08954312
49MP0009046_muscle_twitch1.08042209
50MP0004142_abnormal_muscle_tone1.06849816
51MP0003786_premature_aging1.06590542
52MP0002160_abnormal_reproductive_system1.05407705
53MP0008789_abnormal_olfactory_epithelium1.04731009
54MP0002084_abnormal_developmental_patter1.04007856
55MP0009703_decreased_birth_body1.03960669
56MP0009697_abnormal_copulation1.02351846
57MP0005174_abnormal_tail_pigmentation1.01595967
58MP0001324_abnormal_eye_pigmentation0.99835513
59MP0002697_abnormal_eye_size0.99754121
60MP0002837_dystrophic_cardiac_calcinosis0.99490087
61MP0002928_abnormal_bile_duct0.99332370
62MP0004147_increased_porphyrin_level0.99226942
63MP0003315_abnormal_perineum_morphology0.98394646
64MP0005367_renal/urinary_system_phenotyp0.98277747
65MP0000516_abnormal_urinary_system0.98277747
66MP0003861_abnormal_nervous_system0.96785518
67MP0002095_abnormal_skin_pigmentation0.96582017
68MP0003943_abnormal_hepatobiliary_system0.96559952
69MP0005391_vision/eye_phenotype0.96491973
70MP0003755_abnormal_palate_morphology0.95061808
71MP0003283_abnormal_digestive_organ0.92615951
72MP0002210_abnormal_sex_determination0.91120501
73MP0001929_abnormal_gametogenesis0.90811819
74MP0001697_abnormal_embryo_size0.89950218
75MP0000383_abnormal_hair_follicle0.89163792
76MP0004043_abnormal_pH_regulation0.88976380
77MP0005220_abnormal_exocrine_pancreas0.88897147
78MP0001486_abnormal_startle_reflex0.87715677
79MP0005499_abnormal_olfactory_system0.86937842
80MP0005394_taste/olfaction_phenotype0.86937842
81MP0002736_abnormal_nociception_after0.86518558
82MP0000653_abnormal_sex_gland0.85221968
83MP0001986_abnormal_taste_sensitivity0.84466241
84MP0002163_abnormal_gland_morphology0.84417891
85MP0003938_abnormal_ear_development0.83471835
86MP0000427_abnormal_hair_cycle0.82988006
87MP0001145_abnormal_male_reproductive0.82477244
88MP0005195_abnormal_posterior_eye0.82451252
89MP0002085_abnormal_embryonic_tissue0.82293423
90MP0005084_abnormal_gallbladder_morpholo0.82227480
91MP0009745_abnormal_behavioral_response0.82112849
92MP0002557_abnormal_social/conspecific_i0.81766761
93MP0001968_abnormal_touch/_nociception0.80848402
94MP0002272_abnormal_nervous_system0.80794906
95MP0000955_abnormal_spinal_cord0.79131061
96MP0002752_abnormal_somatic_nervous0.78933805
97MP0001177_atelectasis0.78568483
98MP0003698_abnormal_male_reproductive0.78503666
99MP0008961_abnormal_basal_metabolism0.77338277
100MP0003935_abnormal_craniofacial_develop0.75694219

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.42735799
2Pancreatic fibrosis (HP:0100732)3.29441451
3Intestinal atresia (HP:0011100)3.15263173
4Volvulus (HP:0002580)3.12676545
5Molar tooth sign on MRI (HP:0002419)3.07537401
6Abnormality of midbrain morphology (HP:0002418)3.07537401
7True hermaphroditism (HP:0010459)3.00118671
8Abnormality of the labia minora (HP:0012880)2.97727675
9Abnormality of chromosome stability (HP:0003220)2.86116264
10Nephronophthisis (HP:0000090)2.84290999
11Chronic hepatic failure (HP:0100626)2.79470726
12Aplasia/Hypoplasia of the uvula (HP:0010293)2.78005178
13Meckel diverticulum (HP:0002245)2.71304559
14Abnormality of the ileum (HP:0001549)2.60827793
15Abnormality of the renal medulla (HP:0100957)2.53895784
16Medial flaring of the eyebrow (HP:0010747)2.50922889
17Birth length less than 3rd percentile (HP:0003561)2.50656997
18Colon cancer (HP:0003003)2.48451559
19Chromsome breakage (HP:0040012)2.36685629
20Gastrointestinal atresia (HP:0002589)2.33793660
21Abnormality of the renal cortex (HP:0011035)2.22437828
22Abnormal hair whorl (HP:0010721)2.21770805
23Sloping forehead (HP:0000340)2.20865846
24Cystic liver disease (HP:0006706)2.18390450
25Septo-optic dysplasia (HP:0100842)2.17911903
26Chromosomal breakage induced by crosslinking agents (HP:0003221)2.17840446
27Genital tract atresia (HP:0001827)2.17444841
28Gait imbalance (HP:0002141)2.15896328
29Congenital primary aphakia (HP:0007707)2.13085483
30Vaginal atresia (HP:0000148)2.11394720
31Abnormality of the preputium (HP:0100587)2.07909458
32Hyperventilation (HP:0002883)2.06451029
33Nephrogenic diabetes insipidus (HP:0009806)2.05761822
34Anencephaly (HP:0002323)2.04377803
35Preaxial hand polydactyly (HP:0001177)2.04228106
36Aqueductal stenosis (HP:0002410)2.03934546
37Neoplasm of the adrenal cortex (HP:0100641)2.02245303
38Abnormality of the duodenum (HP:0002246)2.02045896
39Poor coordination (HP:0002370)1.99904515
40Triphalangeal thumb (HP:0001199)1.98957517
41Postaxial foot polydactyly (HP:0001830)1.96826738
42Esophageal atresia (HP:0002032)1.96200483
43Oligodactyly (hands) (HP:0001180)1.95845274
44Drooling (HP:0002307)1.94337650
45Bile duct proliferation (HP:0001408)1.92264169
46Abnormal biliary tract physiology (HP:0012439)1.92264169
47Dandy-Walker malformation (HP:0001305)1.90450045
48Bifid tongue (HP:0010297)1.88549282
49Duodenal stenosis (HP:0100867)1.88333648
50Small intestinal stenosis (HP:0012848)1.88333648
51Ectopic kidney (HP:0000086)1.88268630
52Gaze-evoked nystagmus (HP:0000640)1.87095000
53Aplasia/Hypoplasia of the tongue (HP:0010295)1.85933055
54Small hand (HP:0200055)1.85712670
55Acute necrotizing encephalopathy (HP:0006965)1.85062500
56Narrow forehead (HP:0000341)1.85020897
57Acute encephalopathy (HP:0006846)1.84532944
58Anophthalmia (HP:0000528)1.83239425
59Optic nerve hypoplasia (HP:0000609)1.82657519
60Glioma (HP:0009733)1.81768798
61Clubbing of toes (HP:0100760)1.81598635
62Postaxial hand polydactyly (HP:0001162)1.78251686
63Methylmalonic acidemia (HP:0002912)1.77393751
64Astigmatism (HP:0000483)1.77349709
65Broad-based gait (HP:0002136)1.76475054
66Fair hair (HP:0002286)1.73596307
67Protruding tongue (HP:0010808)1.72936713
68Renal cortical cysts (HP:0000803)1.72427429
69Progressive macrocephaly (HP:0004481)1.72403516
70Neoplasm of the oral cavity (HP:0100649)1.71082979
71Congenital hepatic fibrosis (HP:0002612)1.70807705
72Abnormal lung lobation (HP:0002101)1.70484682
73Patellar aplasia (HP:0006443)1.68618846
74Sclerocornea (HP:0000647)1.68527244
75Cupped ear (HP:0000378)1.68081662
76Supernumerary spleens (HP:0009799)1.68054916
77Oculomotor apraxia (HP:0000657)1.67513883
78Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.66920252
79Hypoplastic labia majora (HP:0000059)1.66856255
80Absent radius (HP:0003974)1.66761137
81Excessive salivation (HP:0003781)1.65701835
82Hepatoblastoma (HP:0002884)1.65677807
83Progressive cerebellar ataxia (HP:0002073)1.65045160
84Increased CSF lactate (HP:0002490)1.63221830
85Highly arched eyebrow (HP:0002553)1.62765044
86Abnormality of the carotid arteries (HP:0005344)1.61976303
87Abnormality of the septum pellucidum (HP:0007375)1.61778823
88Absent septum pellucidum (HP:0001331)1.60466975
89Aplasia involving forearm bones (HP:0009822)1.60239165
90Absent forearm bone (HP:0003953)1.60239165
91Chorioretinal coloboma (HP:0000567)1.59905257
92Abnormality of the pons (HP:0007361)1.58426378
93Aganglionic megacolon (HP:0002251)1.57942821
94Medulloblastoma (HP:0002885)1.57472069
95Aplasia/Hypoplasia of the tibia (HP:0005772)1.57115189
96Cerebellar dysplasia (HP:0007033)1.56895763
97Labial hypoplasia (HP:0000066)1.56449895
98Stenosis of the external auditory canal (HP:0000402)1.55522447
99Progressive inability to walk (HP:0002505)1.55295771
100Male pseudohermaphroditism (HP:0000037)1.55136897

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK23.44591837
2FRK3.37008360
3PNCK3.36783783
4BMPR1B3.16256199
5MKNK12.81943723
6TNIK2.74439207
7WNK32.68401078
8CASK2.46702814
9WEE12.42108505
10BRSK22.41632289
11TRIM282.38784176
12ACVR1B2.19446416
13AKT32.12208908
14NUAK12.06451771
15CDC71.98340338
16BRD41.85882317
17ZAK1.83819952
18TSSK61.72580694
19SRPK11.72255383
20PLK31.70675899
21PLK41.63073150
22ERBB31.43382111
23TAF11.41499824
24MAP3K41.32647833
25EIF2AK31.30892315
26BCR1.30635089
27BUB11.27735590
28PDK21.23524128
29MARK11.22636001
30LATS11.21664627
31FGFR21.16851296
32TTK1.15787137
33VRK11.14908465
34STK38L1.12131803
35MAPK131.09712386
36MAP4K21.06451359
37PLK11.03388652
38STK31.02631239
39WNK41.02062160
40PBK1.01713170
41DYRK31.01299851
42EIF2AK10.96707627
43TGFBR10.96611531
44ATR0.95789815
45STK390.93442374
46GRK10.93205288
47PLK20.91789144
48DYRK20.88814230
49MST40.88711774
50ADRBK20.85923773
51CAMK1G0.85198788
52ATM0.84942900
53CHEK20.82015492
54OXSR10.80869122
55NLK0.79686620
56SGK20.78692298
57BRSK10.78420129
58PAK30.76591102
59STK160.75299540
60PRKCG0.74627414
61EIF2AK20.72847881
62CDK30.72189451
63PASK0.71259378
64INSRR0.70584017
65NEK20.69199006
66CSNK1G10.64327538
67VRK20.64049430
68MAPK150.62917606
69PINK10.62823517
70EPHA40.62128110
71CHEK10.61923864
72CSNK1G20.61518736
73CSNK1E0.61060890
74MINK10.60167605
75FGFR10.59926524
76NME10.52385219
77DYRK1A0.50230835
78NEK10.49414056
79PRKCE0.49320291
80CSNK1D0.48280430
81CDK10.46448984
82SGK2230.44625366
83SGK4940.44625366
84FLT30.44392823
85PRKDC0.43689220
86NTRK20.43591097
87CDK20.43336920
88SIK30.42716697
89CSNK1A1L0.42480096
90AURKB0.39412926
91PRKACB0.38347965
92CCNB10.37027400
93PIK3CA0.35469112
94MUSK0.34755089
95CSNK1G30.34429354
96ERBB40.33506658
97CSNK2A20.33380615
98GSK3B0.33082122
99RPS6KA40.33078263
100NTRK30.32671980

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.23093287
2Protein export_Homo sapiens_hsa030603.09340959
3Homologous recombination_Homo sapiens_hsa034403.07186883
4Fanconi anemia pathway_Homo sapiens_hsa034602.87476909
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.65351658
6Mismatch repair_Homo sapiens_hsa034302.63881219
7RNA polymerase_Homo sapiens_hsa030202.37296298
8Basal transcription factors_Homo sapiens_hsa030222.35994542
9RNA degradation_Homo sapiens_hsa030182.32197861
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.29543453
11Spliceosome_Homo sapiens_hsa030402.22601099
12RNA transport_Homo sapiens_hsa030132.11631853
13Propanoate metabolism_Homo sapiens_hsa006402.02125679
14DNA replication_Homo sapiens_hsa030301.95097127
15One carbon pool by folate_Homo sapiens_hsa006701.77862195
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.75830606
17Butanoate metabolism_Homo sapiens_hsa006501.71802370
18Selenocompound metabolism_Homo sapiens_hsa004501.70679852
19Proteasome_Homo sapiens_hsa030501.67006266
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.64862533
21Oxidative phosphorylation_Homo sapiens_hsa001901.64427821
22Cell cycle_Homo sapiens_hsa041101.63523296
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.62639975
24Nucleotide excision repair_Homo sapiens_hsa034201.54683280
25Phototransduction_Homo sapiens_hsa047441.49227324
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.49019989
27Parkinsons disease_Homo sapiens_hsa050121.46522743
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.46123380
29mRNA surveillance pathway_Homo sapiens_hsa030151.44642849
30Nicotine addiction_Homo sapiens_hsa050331.43245312
31Nitrogen metabolism_Homo sapiens_hsa009101.41774969
32Steroid biosynthesis_Homo sapiens_hsa001001.33916545
33Huntingtons disease_Homo sapiens_hsa050161.32180996
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16181376
35Base excision repair_Homo sapiens_hsa034101.13704889
36Basal cell carcinoma_Homo sapiens_hsa052171.11851957
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09529447
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09391281
39Lysine degradation_Homo sapiens_hsa003101.07886660
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.05780560
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00961430
42Ribosome_Homo sapiens_hsa030101.00850044
43Circadian rhythm_Homo sapiens_hsa047101.00161138
44Tryptophan metabolism_Homo sapiens_hsa003800.99332044
45Hedgehog signaling pathway_Homo sapiens_hsa043400.96990606
46Purine metabolism_Homo sapiens_hsa002300.95664796
47Primary bile acid biosynthesis_Homo sapiens_hsa001200.93987904
48Taste transduction_Homo sapiens_hsa047420.93560979
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93143575
50TGF-beta signaling pathway_Homo sapiens_hsa043500.92870399
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92006094
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91764940
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89225765
54Pyrimidine metabolism_Homo sapiens_hsa002400.89095381
55Oocyte meiosis_Homo sapiens_hsa041140.88388213
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.87984850
57Caffeine metabolism_Homo sapiens_hsa002320.85536330
58Linoleic acid metabolism_Homo sapiens_hsa005910.82844894
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.81373759
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79762670
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78183450
62Chemical carcinogenesis_Homo sapiens_hsa052040.77639316
63Retinol metabolism_Homo sapiens_hsa008300.74055451
64p53 signaling pathway_Homo sapiens_hsa041150.72331919
65Pyruvate metabolism_Homo sapiens_hsa006200.71929747
66Peroxisome_Homo sapiens_hsa041460.69764513
67Alzheimers disease_Homo sapiens_hsa050100.69757771
68Hippo signaling pathway_Homo sapiens_hsa043900.69707108
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66704640
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65466172
71Fatty acid elongation_Homo sapiens_hsa000620.63633136
72Vitamin digestion and absorption_Homo sapiens_hsa049770.61953037
73Ether lipid metabolism_Homo sapiens_hsa005650.58953264
74Wnt signaling pathway_Homo sapiens_hsa043100.58874471
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57354951
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57101901
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55532962
78Colorectal cancer_Homo sapiens_hsa052100.53643957
79Regulation of autophagy_Homo sapiens_hsa041400.53070554
80beta-Alanine metabolism_Homo sapiens_hsa004100.52251495
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51324357
82Folate biosynthesis_Homo sapiens_hsa007900.49877810
83Glutamatergic synapse_Homo sapiens_hsa047240.49246597
84Metabolic pathways_Homo sapiens_hsa011000.49135447
85Cardiac muscle contraction_Homo sapiens_hsa042600.48933398
86Fatty acid metabolism_Homo sapiens_hsa012120.48237116
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48017316
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47923918
89Olfactory transduction_Homo sapiens_hsa047400.45118119
90Serotonergic synapse_Homo sapiens_hsa047260.41410577
91ABC transporters_Homo sapiens_hsa020100.37870813
92Dopaminergic synapse_Homo sapiens_hsa047280.37105144
93Fatty acid degradation_Homo sapiens_hsa000710.34865233
94Morphine addiction_Homo sapiens_hsa050320.34755756
95Insulin secretion_Homo sapiens_hsa049110.33563463
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32682623
97Glutathione metabolism_Homo sapiens_hsa004800.31478653
98Cocaine addiction_Homo sapiens_hsa050300.31097500
99Circadian entrainment_Homo sapiens_hsa047130.31059087
100Fat digestion and absorption_Homo sapiens_hsa049750.29673730

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