ZNF324B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spliceosomal tri-snRNP complex assembly (GO:0000244)5.05631698
2GDP-mannose metabolic process (GO:0019673)4.39106557
3pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.22249259
4regulation of mammary gland epithelial cell proliferation (GO:0033599)4.20100409
5negative regulation of erythrocyte differentiation (GO:0045647)3.84894518
6protein insertion into membrane (GO:0051205)3.82006827
7snRNA metabolic process (GO:0016073)3.80268237
8positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.79494032
9Golgi transport vesicle coating (GO:0048200)3.77456215
10COPI coating of Golgi vesicle (GO:0048205)3.77456215
11modulation by virus of host process (GO:0019054)3.76422215
12DNA unwinding involved in DNA replication (GO:0006268)3.73633156
13pyrimidine nucleotide catabolic process (GO:0006244)3.73405601
14deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.69914641
15proline biosynthetic process (GO:0006561)3.68271424
16peptidyl-arginine omega-N-methylation (GO:0035247)3.63252661
17modulation by symbiont of host cellular process (GO:0044068)3.62127658
18regulation of chromatin binding (GO:0035561)3.48786548
19positive regulation of histone deacetylation (GO:0031065)3.46362673
20negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.44584931
21regulation of protein heterodimerization activity (GO:0043497)3.42448019
22UV protection (GO:0009650)3.34166379
23regulation of translational fidelity (GO:0006450)3.33473121
24apoptotic process involved in morphogenesis (GO:0060561)3.28095951
25cellular response to virus (GO:0098586)3.26093744
26mannose metabolic process (GO:0006013)3.24827076
27embryonic process involved in female pregnancy (GO:0060136)3.19140862
28protein localization to endosome (GO:0036010)3.17316068
29protein retention in ER lumen (GO:0006621)3.15620710
30chaperone mediated protein folding requiring cofactor (GO:0051085)3.14209284
31regulation of type I interferon-mediated signaling pathway (GO:0060338)3.13768179
32retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.11204784
33snRNA processing (GO:0016180)3.08320796
34grooming behavior (GO:0007625)3.06339003
35intracellular estrogen receptor signaling pathway (GO:0030520)3.05092379
36pentose-phosphate shunt (GO:0006098)3.03476992
37negative regulation of cell size (GO:0045792)3.03230852
38dosage compensation (GO:0007549)3.02161067
393-UTR-mediated mRNA stabilization (GO:0070935)2.96355756
40nuclear envelope reassembly (GO:0031468)2.92407372
41mitotic nuclear envelope reassembly (GO:0007084)2.92407372
42negative regulation of viral release from host cell (GO:1902187)2.91799808
43regulation of NFAT protein import into nucleus (GO:0051532)2.91319032
44negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.87808322
45positive regulation of protein deacetylation (GO:0090312)2.85491277
46maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.84217088
47folic acid metabolic process (GO:0046655)2.83599162
48negative regulation of B cell apoptotic process (GO:0002903)2.82336185
49positive regulation of DNA-dependent DNA replication (GO:2000105)2.81551460
50NIK/NF-kappaB signaling (GO:0038061)2.80792394
51DNA duplex unwinding (GO:0032508)2.78575603
52modulation by virus of host morphology or physiology (GO:0019048)2.74960506
53glucose catabolic process (GO:0006007)2.73947324
54nuclear pore complex assembly (GO:0051292)2.73887785
55positive regulation of CREB transcription factor activity (GO:0032793)2.72210202
56poly(A)+ mRNA export from nucleus (GO:0016973)2.70719481
57peptidyl-arginine methylation (GO:0018216)2.70278568
58peptidyl-arginine N-methylation (GO:0035246)2.70278568
59negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.69508939
60ribosomal small subunit biogenesis (GO:0042274)2.67053586
61cell-substrate adherens junction assembly (GO:0007045)2.66489777
62focal adhesion assembly (GO:0048041)2.66489777
63tRNA methylation (GO:0030488)2.65793010
64histone arginine methylation (GO:0034969)2.64789241
65chromatin assembly (GO:0031497)2.64253925
66activation of Rac GTPase activity (GO:0032863)2.64101846
67rRNA transcription (GO:0009303)2.63873000
68mitochondrial fusion (GO:0008053)2.63736375
69regulation of monocyte differentiation (GO:0045655)2.63357917
70protein-DNA complex disassembly (GO:0032986)2.63073778
71nucleosome disassembly (GO:0006337)2.63073778
72mitotic chromosome condensation (GO:0007076)2.62704397
73glucocorticoid receptor signaling pathway (GO:0042921)2.60830191
74DNA strand elongation (GO:0022616)2.60495773
75adherens junction assembly (GO:0034333)2.58819819
76DNA replication initiation (GO:0006270)2.58714914
77G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.58511510
78positive regulation of receptor biosynthetic process (GO:0010870)2.57275494
79positive regulation of keratinocyte differentiation (GO:0045618)2.57014716
80thymic T cell selection (GO:0045061)2.56050607
81negative regulation of mRNA processing (GO:0050686)2.54092194
82activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.52976939
83negative regulation of granulocyte differentiation (GO:0030853)2.51804720
84regulation of viral release from host cell (GO:1902186)2.50052579
85DNA geometric change (GO:0032392)2.50036326
86DNA strand elongation involved in DNA replication (GO:0006271)2.49455853
87positive regulation of nuclease activity (GO:0032075)2.47671439
88vascular endothelial growth factor signaling pathway (GO:0038084)2.45621425
89barbed-end actin filament capping (GO:0051016)2.45337738
90definitive hemopoiesis (GO:0060216)2.43041210
91ribosome biogenesis (GO:0042254)2.43006571
92mitotic G1 DNA damage checkpoint (GO:0031571)2.42764056
93T cell lineage commitment (GO:0002360)2.42608334
94NADPH regeneration (GO:0006740)2.42284063
95nuclear envelope organization (GO:0006998)2.40980531
96regulation of glucose import in response to insulin stimulus (GO:2001273)2.40264570
97corticosteroid receptor signaling pathway (GO:0031958)2.38910831
98pattern specification involved in kidney development (GO:0061004)2.38885358
99nucleobase-containing small molecule interconversion (GO:0015949)2.37463965
100proline metabolic process (GO:0006560)2.37191694

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.78423052
2VDR_21846776_ChIP-Seq_THP-1_Human3.67349857
3MYC_22102868_ChIP-Seq_BL_Human3.21549126
4TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.73477348
5LXR_22292898_ChIP-Seq_THP-1_Human2.55337982
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.53483243
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.38646067
8KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.28428279
9ELK3_25401928_ChIP-Seq_HUVEC_Human2.13043594
10DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.07268364
11KDM2B_26808549_Chip-Seq_SUP-B15_Human2.06790444
12XRN2_22483619_ChIP-Seq_HELA_Human1.93211121
13TP63_17297297_ChIP-ChIP_HaCaT_Human1.92501795
14KDM2B_26808549_Chip-Seq_DND41_Human1.85865041
15RACK7_27058665_Chip-Seq_MCF-7_Human1.81435963
16CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.77904656
17TCF7_22412390_ChIP-Seq_EML_Mouse1.76676873
18P68_20966046_ChIP-Seq_HELA_Human1.73738952
19MAF_26560356_Chip-Seq_TH2_Human1.71198732
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.69959831
21CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.69925198
22MYC_18555785_ChIP-Seq_MESCs_Mouse1.69094348
23MYC_18358816_ChIP-ChIP_MESCs_Mouse1.68107877
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.67623927
25MAF_26560356_Chip-Seq_TH1_Human1.65826361
26VDR_24763502_ChIP-Seq_THP-1_Human1.63661857
27TET1_21451524_ChIP-Seq_MESCs_Mouse1.62691025
28THAP11_20581084_ChIP-Seq_MESCs_Mouse1.62248472
29ZNF263_19887448_ChIP-Seq_K562_Human1.60424157
30CIITA_25753668_ChIP-Seq_RAJI_Human1.60316109
31PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.57178301
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.56391537
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.54038626
34KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.52306505
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52172285
36CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.51886913
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.51541608
38UTX_26944678_Chip-Seq_JUKART_Human1.50298767
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.48053117
40CTCF_27219007_Chip-Seq_ERYTHROID_Human1.44510186
41ESR1_15608294_ChIP-ChIP_MCF-7_Human1.42904879
42CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.42234198
43JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.40681981
44ELF1_20517297_ChIP-Seq_JURKAT_Human1.40103980
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38715033
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.38349601
47SA1_27219007_Chip-Seq_ERYTHROID_Human1.36454458
48* GABP_19822575_ChIP-Seq_HepG2_Human1.33646705
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33562279
50SRY_22984422_ChIP-ChIP_TESTIS_Rat1.32847080
51MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.31173584
52KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.31161107
53KDM2B_26808549_Chip-Seq_JURKAT_Human1.30375526
54E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29869664
55MYC_19030024_ChIP-ChIP_MESCs_Mouse1.29239383
56KDM5A_27292631_Chip-Seq_BREAST_Human1.29179534
57FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.28549913
58ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.28190955
59SMC4_20622854_ChIP-Seq_HELA_Human1.27967758
60ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27801080
61BCOR_27268052_Chip-Seq_Bcells_Human1.24067064
62NCOR1_26117541_ChIP-Seq_K562_Human1.23721831
63BCL6_27268052_Chip-Seq_Bcells_Human1.20856465
64NELFA_20434984_ChIP-Seq_ESCs_Mouse1.20122392
65KDM2B_26808549_Chip-Seq_K562_Human1.19571987
66MYC_19079543_ChIP-ChIP_MESCs_Mouse1.19569276
67UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18514980
68ETS1_20019798_ChIP-Seq_JURKAT_Human1.18149525
69CREB1_26743006_Chip-Seq_LNCaP_Human1.17381163
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16613779
71TP53_22127205_ChIP-Seq_IMR90_Human1.15491396
72ATF3_27146783_Chip-Seq_COLON_Human1.15341097
73SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.14813252
74EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14686244
75SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13990358
76BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13175589
77PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13054396
78HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11897304
79RARA_24833708_ChIP-Seq_LIVER_Mouse1.11420472
80RUNX1_22412390_ChIP-Seq_EML_Mouse1.11233454
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10803114
82SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09793431
83CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09270775
84PHF8_20622854_ChIP-Seq_HELA_Human1.08715280
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.08564746
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07785613
87MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.06730816
88MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.06396744
89TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06010509
90CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05661822
91SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05612427
92GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05344563
93CTCF_26484167_Chip-Seq_Bcells_Mouse1.05120396
94POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.05110061
95CTCF_21964334_Chip-Seq_Bcells_Human1.04922929
96KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04230754
97PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04036194
98UBF1/2_26484160_Chip-Seq_HMECs_Human1.03919003
99CTCF_21964334_ChIP-Seq_BJAB-B_Human1.03862293
100CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03414443

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.58129040
2MP0005076_abnormal_cell_differentiation3.53528029
3MP0003705_abnormal_hypodermis_morpholog3.36625793
4MP0005058_abnormal_lysosome_morphology2.63965489
5MP0003111_abnormal_nucleus_morphology2.46669048
6MP0009278_abnormal_bone_marrow2.44244021
7MP0002877_abnormal_melanocyte_morpholog2.35317865
8MP0001849_ear_inflammation2.26495955
9MP0010094_abnormal_chromosome_stability2.10362681
10MP0000003_abnormal_adipose_tissue2.05135179
11MP0003436_decreased_susceptibility_to1.99088697
12MP0001348_abnormal_lacrimal_gland1.95252937
13MP0000013_abnormal_adipose_tissue1.93576275
14MP0003763_abnormal_thymus_physiology1.89163133
15MP0009840_abnormal_foam_cell1.88477125
16MP0003172_abnormal_lysosome_physiology1.84411034
17MP0000678_abnormal_parathyroid_gland1.81980437
18MP0005623_abnormal_meninges_morphology1.78801364
19MP0002396_abnormal_hematopoietic_system1.78799302
20MP0004233_abnormal_muscle_weight1.77423387
21MP0004185_abnormal_adipocyte_glucose1.77403985
22MP0003077_abnormal_cell_cycle1.74974594
23MP0004808_abnormal_hematopoietic_stem1.73102936
24MP0008260_abnormal_autophagy1.54904906
25MP0000490_abnormal_crypts_of1.54196162
26MP0001873_stomach_inflammation1.51311029
27MP0003693_abnormal_embryo_hatching1.46844816
28MP0002009_preneoplasia1.45706051
29MP0003091_abnormal_cell_migration1.45630905
30MP0003303_peritoneal_inflammation1.43870839
31MP0009384_cardiac_valve_regurgitation1.42745258
32MP0009333_abnormal_splenocyte_physiolog1.41742602
33MP0001661_extended_life_span1.40529877
34MP0000465_gastrointestinal_hemorrhage1.39555609
35MP0000350_abnormal_cell_proliferation1.39002848
36MP0003191_abnormal_cellular_cholesterol1.38928188
37MP0003453_abnormal_keratinocyte_physiol1.38191421
38MP0005501_abnormal_skin_physiology1.37373534
39MP0004947_skin_inflammation1.37053364
40MP0003566_abnormal_cell_adhesion1.35793946
41MP0004381_abnormal_hair_follicle1.34355472
42MP0001835_abnormal_antigen_presentation1.28693696
43MP0005310_abnormal_salivary_gland1.27935111
44MP0000733_abnormal_muscle_development1.26162345
45MP0001730_embryonic_growth_arrest1.23414465
46MP0000681_abnormal_thyroid_gland1.23086257
47MP0002249_abnormal_larynx_morphology1.21511984
48MP0000015_abnormal_ear_pigmentation1.20899664
49MP0008932_abnormal_embryonic_tissue1.19785102
50MP0002398_abnormal_bone_marrow1.18036068
51MP0005621_abnormal_cell_physiology1.16930160
52MP0002080_prenatal_lethality1.16188329
53MP0005375_adipose_tissue_phenotype1.15140183
54MP0000537_abnormal_urethra_morphology1.14123458
55MP0000313_abnormal_cell_death1.13504240
56MP0003329_amyloid_beta_deposits1.10086111
57MP0008007_abnormal_cellular_replicative1.09203489
58MP0000747_muscle_weakness1.09139895
59MP0002019_abnormal_tumor_incidence1.04314245
60MP0003984_embryonic_growth_retardation1.03193297
61MP0009931_abnormal_skin_appearance1.02588779
62MP0010307_abnormal_tumor_latency1.02324166
63MP0005000_abnormal_immune_tolerance1.02061450
64MP0000703_abnormal_thymus_morphology1.01138751
65MP0000358_abnormal_cell_content/0.99801145
66MP0002429_abnormal_blood_cell0.98880870
67MP0005220_abnormal_exocrine_pancreas0.98815638
68MP0005083_abnormal_biliary_tract0.97914623
69MP0002405_respiratory_system_inflammati0.97063515
70MP0003866_abnormal_defecation0.95619897
71MP0005380_embryogenesis_phenotype0.95414577
72MP0001672_abnormal_embryogenesis/_devel0.95414577
73MP0005384_cellular_phenotype0.95244134
74MP0000858_altered_metastatic_potential0.95241606
75MP0002722_abnormal_immune_system0.94706112
76MP0004957_abnormal_blastocyst_morpholog0.94042657
77MP0001727_abnormal_embryo_implantation0.93133263
78MP0002088_abnormal_embryonic_growth/wei0.93074589
79MP0005257_abnormal_intraocular_pressure0.92502000
80MP0002086_abnormal_extraembryonic_tissu0.92267037
81MP0003300_gastrointestinal_ulcer0.91575433
82MP0000685_abnormal_immune_system0.89332103
83MP0002822_catalepsy0.89037432
84MP0000538_abnormal_urinary_bladder0.88387245
85MP0002166_altered_tumor_susceptibility0.88252135
86MP0003315_abnormal_perineum_morphology0.87760008
87MP0005645_abnormal_hypothalamus_physiol0.86801392
88MP0004858_abnormal_nervous_system0.86405667
89MP0005397_hematopoietic_system_phenotyp0.86267023
90MP0001545_abnormal_hematopoietic_system0.86267023
91MP0001915_intracranial_hemorrhage0.86003344
92MP0000759_abnormal_skeletal_muscle0.85551130
93MP0002796_impaired_skin_barrier0.85279705
94MP0002092_abnormal_eye_morphology0.83768184
95MP0002420_abnormal_adaptive_immunity0.83742808
96MP0001800_abnormal_humoral_immune0.83379830
97MP0005666_abnormal_adipose_tissue0.83312917
98MP0002723_abnormal_immune_serum0.83228062
99MP0001697_abnormal_embryo_size0.83213253
100MP0000716_abnormal_immune_system0.82728911

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)4.36865495
2Ulnar bowing (HP:0003031)3.88483347
3Ragged-red muscle fibers (HP:0003200)3.74506266
4Progressive muscle weakness (HP:0003323)3.22950160
5Myopathic facies (HP:0002058)3.02067159
6Poikiloderma (HP:0001029)2.84921321
7Achilles tendon contracture (HP:0001771)2.81250950
8Insomnia (HP:0100785)2.72428185
9Broad face (HP:0000283)2.70173633
10Testicular atrophy (HP:0000029)2.65341598
11Progressive external ophthalmoplegia (HP:0000590)2.62580658
12Thin bony cortex (HP:0002753)2.62276859
13Squamous cell carcinoma (HP:0002860)2.55409063
14Urethral obstruction (HP:0000796)2.53653363
15Annular pancreas (HP:0001734)2.52721546
16Colitis (HP:0002583)2.52117165
17Cellulitis (HP:0100658)2.47423997
18Breast hypoplasia (HP:0003187)2.43823920
19Hypertensive crisis (HP:0100735)2.42556349
20Distal lower limb amyotrophy (HP:0008944)2.39371571
21Abnormality of the thoracic spine (HP:0100711)2.37948244
22Thoracic kyphosis (HP:0002942)2.33224336
23Microvesicular hepatic steatosis (HP:0001414)2.32473861
24Abnormality of the Achilles tendon (HP:0005109)2.31106306
25Interstitial pulmonary disease (HP:0006530)2.30219823
26Disproportionate tall stature (HP:0001519)2.30174826
27Entropion (HP:0000621)2.29281534
28Syringomyelia (HP:0003396)2.22239587
29Spinal cord lesions (HP:0100561)2.22239587
30Pointed chin (HP:0000307)2.21628494
31Hemorrhage of the eye (HP:0011885)2.18164259
32Long palpebral fissure (HP:0000637)2.18076141
33Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.12008153
34Centrally nucleated skeletal muscle fibers (HP:0003687)2.11601427
35Elfin facies (HP:0004428)2.10908899
36Gastrointestinal inflammation (HP:0004386)2.10314991
37Atelectasis (HP:0100750)2.10024911
38Abnormality of liposaccharide metabolism (HP:0010968)2.08602343
39Abnormality of glycosphingolipid metabolism (HP:0004343)2.08602343
40Abnormality of glycolipid metabolism (HP:0010969)2.08602343
41Congenital hip dislocation (HP:0001374)2.07296620
42Broad distal phalanx of finger (HP:0009836)2.06801921
43Upper limb amyotrophy (HP:0009129)2.06768422
44Distal upper limb amyotrophy (HP:0007149)2.06768422
45Upper motor neuron abnormality (HP:0002127)2.06263847
46Self-mutilation (HP:0000742)2.03811331
47Stridor (HP:0010307)2.03788046
48Patellar dislocation (HP:0002999)1.99229252
49Increased connective tissue (HP:0009025)1.98060764
50Deviation of the thumb (HP:0009603)1.96570791
51Deep palmar crease (HP:0006191)1.95764763
52Natal tooth (HP:0000695)1.92557966
53Elbow flexion contracture (HP:0002987)1.91460432
54Recurrent viral infections (HP:0004429)1.91407098
55Increased IgE level (HP:0003212)1.88326042
56Thrombocytosis (HP:0001894)1.87797186
57Aplasia/Hypoplasia of the sacrum (HP:0008517)1.85774026
58Bowing of the arm (HP:0006488)1.84203818
59Bowed forearm bones (HP:0003956)1.84203818
60Premature skin wrinkling (HP:0100678)1.83895936
61High anterior hairline (HP:0009890)1.81892642
62Cholecystitis (HP:0001082)1.81504286
63Abnormal gallbladder physiology (HP:0012438)1.81504286
64Rough bone trabeculation (HP:0100670)1.80104474
65Increased cerebral lipofuscin (HP:0011813)1.79341663
66Dysmetric saccades (HP:0000641)1.78800710
67Spina bifida occulta (HP:0003298)1.78443145
68Hypercortisolism (HP:0001578)1.78382776
69Short nail (HP:0001799)1.77290825
70IgA deficiency (HP:0002720)1.77134667
71Spastic diplegia (HP:0001264)1.77127688
72Flattened epiphyses (HP:0003071)1.72786359
73Increased muscle lipid content (HP:0009058)1.72458937
74Spinal rigidity (HP:0003306)1.71735474
75Trismus (HP:0000211)1.70469235
76Abnormality of the fingertips (HP:0001211)1.70083037
77Cervical subluxation (HP:0003308)1.69859339
78Proximal placement of thumb (HP:0009623)1.68061362
79Reticulocytosis (HP:0001923)1.68048390
80Hand muscle atrophy (HP:0009130)1.66502950
81Joint stiffness (HP:0001387)1.66259691
82Abnormality of the umbilical cord (HP:0010881)1.65080085
83Renovascular hypertension (HP:0100817)1.64854308
84Aplastic anemia (HP:0001915)1.64509697
85Increased neuronal autofluorescent lipopigment (HP:0002074)1.63959531
86Villous atrophy (HP:0011473)1.63815097
87Abnormality of small intestinal villus morphology (HP:0011472)1.63815097
88Dislocated radial head (HP:0003083)1.63190865
89Flat cornea (HP:0007720)1.63014865
90Orthostatic hypotension (HP:0001278)1.62875719
91Overriding aorta (HP:0002623)1.62420024
92Recurrent abscess formation (HP:0002722)1.62007293
93Increased variability in muscle fiber diameter (HP:0003557)1.61683251
94Vertebral compression fractures (HP:0002953)1.61388489
95Abnormality of the radial head (HP:0003995)1.60000290
96High pitched voice (HP:0001620)1.59665736
97Birth length less than 3rd percentile (HP:0003561)1.59567082
98Difficulty climbing stairs (HP:0003551)1.58533391
99Genu recurvatum (HP:0002816)1.58251241
100Renal duplication (HP:0000075)1.57346972

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.57712432
2SMG13.77511726
3EEF2K3.33996674
4SIK13.11945703
5IRAK32.87590357
6ICK2.84386098
7NME22.84009104
8CDK122.73216527
9PRPF4B2.68498819
10ERN12.50801023
11PRKD21.90275537
12MAP2K31.85537999
13PIM21.57713483
14SIK21.56133745
15PRKD31.54137600
16MAP3K101.47587455
17TAOK21.47178755
18TTN1.44340631
19MAP3K111.41759932
20PKN21.41559945
21BCKDK1.40862142
22MAPK151.40499804
23TESK21.34692648
24TBK11.29445207
25SCYL21.28044560
26CDK41.25742003
27FLT31.25180413
28ARAF1.23875794
29MTOR1.12299501
30NME11.10083212
31TAOK11.01880649
32MARK21.00364668
33AURKA0.97311333
34CCNB10.96359675
35CAMK1D0.96184088
36EPHA20.96111662
37CHEK20.95666384
38MAP4K10.94355200
39TLK10.93319392
40MAPK110.91556998
41IRAK40.89030470
42RPS6KB20.88959062
43RPS6KL10.83884005
44RPS6KC10.83884005
45IRAK20.82095229
46MST1R0.80724907
47CDK70.80332824
48MAP3K130.78587492
49KDR0.78326857
50MAP2K20.76262483
51RPS6KA20.74479446
52BRAF0.74454771
53MAP3K80.73731738
54DAPK10.70098786
55BLK0.69631060
56MAP3K30.68514370
57CDK60.67303998
58MAP3K10.66946593
59RPS6KA60.66645538
60BTK0.65455261
61ATR0.62476869
62STK40.62199608
63HIPK20.61542793
64MAP3K140.61106439
65PDPK10.60210796
66RPS6KA50.58178246
67CHEK10.57883082
68TESK10.57751002
69BMX0.56139120
70AKT20.56053104
71CDK80.54900268
72SIK30.52036063
73LRRK20.51470063
74RAF10.51286413
75CSF1R0.50670271
76AURKB0.50424292
77NEK90.50224606
78CAMK1G0.48518560
79TYK20.47024311
80PBK0.46482577
81NTRK10.46391512
82MARK30.45790416
83CDK90.45533103
84CDC70.45394789
85RET0.45352647
86RIPK40.44737587
87IKBKB0.44647838
88EPHB10.44463655
89MELK0.44450201
90MAP3K60.43897299
91CAMKK10.43858390
92DAPK30.43839868
93CDK20.41518677
94PRKCH0.41328314
95KSR20.41052788
96PIM10.40980525
97IKBKE0.40688436
98GRK60.40607386
99PDGFRA0.37075245
100FGFR40.35804483

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.87997309
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.30257612
3DNA replication_Homo sapiens_hsa030302.38740780
4Base excision repair_Homo sapiens_hsa034102.17292842
5Systemic lupus erythematosus_Homo sapiens_hsa053222.15255655
6Fructose and mannose metabolism_Homo sapiens_hsa000512.07389607
7Bladder cancer_Homo sapiens_hsa052191.94474268
8Non-small cell lung cancer_Homo sapiens_hsa052231.91252873
9Other glycan degradation_Homo sapiens_hsa005111.90352301
10Acute myeloid leukemia_Homo sapiens_hsa052211.84433492
11Chronic myeloid leukemia_Homo sapiens_hsa052201.78689837
12Pentose phosphate pathway_Homo sapiens_hsa000301.72410185
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.72142273
14B cell receptor signaling pathway_Homo sapiens_hsa046621.70819843
15Notch signaling pathway_Homo sapiens_hsa043301.66114244
16Biosynthesis of amino acids_Homo sapiens_hsa012301.65558625
17Pancreatic cancer_Homo sapiens_hsa052121.65156060
18Central carbon metabolism in cancer_Homo sapiens_hsa052301.59528825
19Alcoholism_Homo sapiens_hsa050341.55327680
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.44635552
21Viral carcinogenesis_Homo sapiens_hsa052031.42397997
22Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.41958927
23VEGF signaling pathway_Homo sapiens_hsa043701.30106693
24Hepatitis B_Homo sapiens_hsa051611.29434401
25Pyrimidine metabolism_Homo sapiens_hsa002401.22896676
26mTOR signaling pathway_Homo sapiens_hsa041501.22295933
27N-Glycan biosynthesis_Homo sapiens_hsa005101.17362587
28Neurotrophin signaling pathway_Homo sapiens_hsa047221.15922033
29Apoptosis_Homo sapiens_hsa042101.12940975
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.07005940
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.06943334
32Endometrial cancer_Homo sapiens_hsa052131.05887458
33Small cell lung cancer_Homo sapiens_hsa052221.04944370
34Galactose metabolism_Homo sapiens_hsa000521.04235284
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03806425
36Herpes simplex infection_Homo sapiens_hsa051681.01228303
37Thyroid hormone signaling pathway_Homo sapiens_hsa049190.97432886
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97296028
39Primary immunodeficiency_Homo sapiens_hsa053400.96362665
40Epstein-Barr virus infection_Homo sapiens_hsa051690.94721223
41Hepatitis C_Homo sapiens_hsa051600.94303589
42HTLV-I infection_Homo sapiens_hsa051660.91296145
43Cell cycle_Homo sapiens_hsa041100.91093822
44Carbon metabolism_Homo sapiens_hsa012000.90997255
45mRNA surveillance pathway_Homo sapiens_hsa030150.90689588
46Influenza A_Homo sapiens_hsa051640.90444634
47Toll-like receptor signaling pathway_Homo sapiens_hsa046200.90040752
48Fanconi anemia pathway_Homo sapiens_hsa034600.89166428
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89071774
50Spliceosome_Homo sapiens_hsa030400.87766758
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85293560
52ErbB signaling pathway_Homo sapiens_hsa040120.83743818
53Colorectal cancer_Homo sapiens_hsa052100.83144324
54Glioma_Homo sapiens_hsa052140.82256098
55Inositol phosphate metabolism_Homo sapiens_hsa005620.79779017
56Toxoplasmosis_Homo sapiens_hsa051450.79556227
57Prostate cancer_Homo sapiens_hsa052150.78031304
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77587441
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77542256
60Nucleotide excision repair_Homo sapiens_hsa034200.74797078
61Shigellosis_Homo sapiens_hsa051310.74364123
62Lysosome_Homo sapiens_hsa041420.73973381
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73567865
64Lysine degradation_Homo sapiens_hsa003100.71379391
65MicroRNAs in cancer_Homo sapiens_hsa052060.70259283
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70170824
67Measles_Homo sapiens_hsa051620.69152771
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67465933
69AMPK signaling pathway_Homo sapiens_hsa041520.66330576
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65873941
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.65732373
72Osteoclast differentiation_Homo sapiens_hsa043800.65165576
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65117181
74Insulin signaling pathway_Homo sapiens_hsa049100.64483519
75RNA transport_Homo sapiens_hsa030130.64284686
76TNF signaling pathway_Homo sapiens_hsa046680.60564748
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.59485792
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58732260
79Viral myocarditis_Homo sapiens_hsa054160.57761460
80Thyroid cancer_Homo sapiens_hsa052160.57437954
81Insulin resistance_Homo sapiens_hsa049310.56330157
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55639337
83Homologous recombination_Homo sapiens_hsa034400.55281774
84Endocytosis_Homo sapiens_hsa041440.55197917
85Renal cell carcinoma_Homo sapiens_hsa052110.54703296
86Non-homologous end-joining_Homo sapiens_hsa034500.54147214
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53834222
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52694868
89Leishmaniasis_Homo sapiens_hsa051400.52559802
90Prolactin signaling pathway_Homo sapiens_hsa049170.52339113
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51277140
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51012274
93Proteoglycans in cancer_Homo sapiens_hsa052050.50943625
94Tuberculosis_Homo sapiens_hsa051520.50714531
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.49075522
96HIF-1 signaling pathway_Homo sapiens_hsa040660.49020941
97Selenocompound metabolism_Homo sapiens_hsa004500.48942868
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47463189
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.47320744
100Prion diseases_Homo sapiens_hsa050200.46234439

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