ZNF324

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1GDP-mannose metabolic process (GO:0019673)7.91335782
2cellular response to ATP (GO:0071318)7.73556548
3negative regulation of cell aging (GO:0090344)7.46073873
4DNA strand renaturation (GO:0000733)6.67632776
5adenosine receptor signaling pathway (GO:0001973)6.29588700
6regulation of skeletal muscle contraction (GO:0014819)5.99296795
7negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)5.98665684
8regulation of synapse structural plasticity (GO:0051823)5.98340561
9meiotic chromosome segregation (GO:0045132)5.97714101
10G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.64833501
11rRNA methylation (GO:0031167)5.33107976
12mitotic cell cycle arrest (GO:0071850)5.12048329
13purinergic nucleotide receptor signaling pathway (GO:0035590)5.08448139
14regulation of cytokine production involved in inflammatory response (GO:1900015)5.03831931
15rRNA modification (GO:0000154)4.71958735
16protein carboxylation (GO:0018214)4.62615721
17peptidyl-glutamic acid carboxylation (GO:0017187)4.62615721
18lens fiber cell differentiation (GO:0070306)4.56398144
19adenine nucleotide transport (GO:0051503)4.51189700
20positive regulation of protein kinase C signaling (GO:0090037)4.49275367
21purine ribonucleotide transport (GO:0015868)4.29111364
22sensory perception of taste (GO:0050909)4.26819523
23UV protection (GO:0009650)4.23138252
24mannose metabolic process (GO:0006013)4.18279708
25protein insertion into membrane (GO:0051205)4.16069848
26regulation of chromatin binding (GO:0035561)4.07651011
27response to ATP (GO:0033198)4.06408882
28purinergic receptor signaling pathway (GO:0035587)3.91198192
29granulocyte differentiation (GO:0030851)3.90443548
30regulation of protein kinase A signaling (GO:0010738)3.76154185
31negative regulation of interleukin-8 production (GO:0032717)3.75899709
32DNA replication checkpoint (GO:0000076)3.75392210
33G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.67814069
34tRNA modification (GO:0006400)3.63712852
35phosphatidylglycerol biosynthetic process (GO:0006655)3.61573639
36positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.58344350
37regulation of cell aging (GO:0090342)3.55814799
38urinary tract smooth muscle contraction (GO:0014848)3.51195918
39peptidyl-histidine modification (GO:0018202)3.50328862
40positive regulation of heat generation (GO:0031652)3.47687667
41detection of light stimulus involved in visual perception (GO:0050908)3.46084703
42detection of light stimulus involved in sensory perception (GO:0050962)3.46084703
43behavioral response to nicotine (GO:0035095)3.40499862
44folic acid metabolic process (GO:0046655)3.38591459
45cell migration in hindbrain (GO:0021535)3.37856991
46positive regulation of protein homooligomerization (GO:0032464)3.37505307
47histone phosphorylation (GO:0016572)3.31574832
48semaphorin-plexin signaling pathway (GO:0071526)3.29594597
49sphingomyelin metabolic process (GO:0006684)3.28803256
50transepithelial transport (GO:0070633)3.24725983
51base-excision repair, AP site formation (GO:0006285)3.24063238
52purine nucleotide transport (GO:0015865)3.22012338
53nucleoside transmembrane transport (GO:1901642)3.18248017
54regulation of nuclear cell cycle DNA replication (GO:0033262)3.13821665
55snRNA transcription (GO:0009301)3.11251851
56RNA methylation (GO:0001510)3.09528658
57negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)3.09477658
58grooming behavior (GO:0007625)3.02770757
59sialylation (GO:0097503)3.00910321
60mitochondrion distribution (GO:0048311)2.99580330
61histone H3-K4 methylation (GO:0051568)2.93666103
62iron-sulfur cluster assembly (GO:0016226)2.92702379
63metallo-sulfur cluster assembly (GO:0031163)2.92702379
64nucleotide-sugar biosynthetic process (GO:0009226)2.89790059
65sulfur amino acid catabolic process (GO:0000098)2.89227398
66sex determination (GO:0007530)2.85330063
67DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.81136472
68purine deoxyribonucleotide catabolic process (GO:0009155)2.80798641
69estrogen biosynthetic process (GO:0006703)2.79669864
70cilium or flagellum-dependent cell motility (GO:0001539)2.78194311
71snRNA metabolic process (GO:0016073)2.78065025
72CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.77936363
73regulation of mammary gland epithelial cell proliferation (GO:0033599)2.74034800
74histone H3-K4 trimethylation (GO:0080182)2.73046461
75regulation of phospholipid biosynthetic process (GO:0071071)2.72818038
76RNA modification (GO:0009451)2.72723177
77DNA duplex unwinding (GO:0032508)2.72504034
78dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.70544290
79mitochondrial DNA metabolic process (GO:0032042)2.69744015
80mRNA cleavage (GO:0006379)2.69156859
81positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.66721036
82misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.66156255
83endocytic recycling (GO:0032456)2.63729790
84melanin biosynthetic process (GO:0042438)2.62980872
85melanin metabolic process (GO:0006582)2.62422700
86ganglioside metabolic process (GO:0001573)2.62067559
87pseudouridine synthesis (GO:0001522)2.61523801
88neuromuscular synaptic transmission (GO:0007274)2.59552159
89sphingosine metabolic process (GO:0006670)2.59441382
90DNA damage response, signal transduction resulting in transcription (GO:0042772)2.57331579
91regulation of NFAT protein import into nucleus (GO:0051532)2.56829772
92peptidyl-lysine methylation (GO:0018022)2.56353990
93DNA geometric change (GO:0032392)2.55365550
94histone H3 deacetylation (GO:0070932)2.54576719
95modulation by virus of host process (GO:0019054)2.54085360
96histone H4 deacetylation (GO:0070933)2.53624662
97regulation of heat generation (GO:0031650)2.52737816
98gonadal mesoderm development (GO:0007506)2.52162831
99positive regulation of mitochondrial fission (GO:0090141)2.51897220
100proline biosynthetic process (GO:0006561)2.50569689

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human4.43468333
2TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse3.25893433
3STAT6_21828071_ChIP-Seq_BEAS2B_Human2.84953157
4LXR_22292898_ChIP-Seq_THP-1_Human2.79241129
5CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.71227006
6P68_20966046_ChIP-Seq_HELA_Human2.62735662
7XRN2_22483619_ChIP-Seq_HELA_Human2.61745875
8MYC_22102868_ChIP-Seq_BL_Human2.58172560
9MAF_26560356_Chip-Seq_TH2_Human2.40983567
10DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.40421114
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.26075518
12KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.19481996
13KDM2B_26808549_Chip-Seq_SUP-B15_Human2.09794127
14MAF_26560356_Chip-Seq_TH1_Human2.05447973
15VDR_24763502_ChIP-Seq_THP-1_Human2.05352569
16RACK7_27058665_Chip-Seq_MCF-7_Human2.04204676
17KDM2B_26808549_Chip-Seq_DND41_Human1.99838124
18TET1_21451524_ChIP-Seq_MESCs_Mouse1.98632932
19BCOR_27268052_Chip-Seq_Bcells_Human1.97275318
20BCL6_27268052_Chip-Seq_Bcells_Human1.97099136
21E2F1_20622854_ChIP-Seq_HELA_Human1.93937076
22CTCF_27219007_Chip-Seq_ERYTHROID_Human1.92304324
23CIITA_25753668_ChIP-Seq_RAJI_Human1.88921758
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.88099254
25MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.86730000
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.84580075
27PHF8_20622854_ChIP-Seq_HELA_Human1.81145189
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.80993231
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.75500592
30CTCF_27219007_Chip-Seq_Bcells_Human1.67798791
31TCF7_22412390_ChIP-Seq_EML_Mouse1.67474955
32UTX_26944678_Chip-Seq_JUKART_Human1.67075009
33SMC4_20622854_ChIP-Seq_HELA_Human1.66523146
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.65730494
35RARB_24833708_ChIP-Seq_LIVER_Mouse1.65103557
36CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.63934682
37CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.63468947
38CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.62903247
39ELF1_20517297_ChIP-Seq_JURKAT_Human1.61708159
40SA1_27219007_Chip-Seq_ERYTHROID_Human1.61166031
41CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.60802503
42CTCF_21964334_Chip-Seq_Bcells_Human1.59090997
43FOXP1_21924763_ChIP-Seq_HESCs_Human1.58938456
44RARA_24833708_ChIP-Seq_LIVER_Mouse1.54638470
45CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.52626784
46GABP_19822575_ChIP-Seq_HepG2_Human1.52473246
47DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.51771397
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.51484935
49RARG_19884340_ChIP-ChIP_MEFs_Mouse1.51480850
50CREB1_26743006_Chip-Seq_LNCaP_Human1.51466437
51TP53_22127205_ChIP-Seq_IMR90_Human1.51199922
52SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.48590856
53PKCTHETA_26484144_Chip-Seq_BREAST_Human1.47397589
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.45658190
55RXRA_24833708_ChIP-Seq_LIVER_Mouse1.44917927
56BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.43378209
57FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.41031739
58KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.39530845
59DCP1A_22483619_ChIP-Seq_HELA_Human1.39341150
60EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.38680604
61THAP11_20581084_ChIP-Seq_MESCs_Mouse1.38091560
62FOXM1_23109430_ChIP-Seq_U2OS_Human1.37593418
63SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34489774
64SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34489546
65CTCF_21964334_ChIP-Seq_BJAB-B_Human1.33940842
66SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33771114
67ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.33672324
68SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32794614
69ETS1_20019798_ChIP-Seq_JURKAT_Human1.31734081
70PU.1_20513432_ChIP-Seq_Bcells_Mouse1.30890597
71CTCF_20526341_ChIP-Seq_ESCs_Human1.28468211
72KDM2B_26808549_Chip-Seq_JURKAT_Human1.27908170
73E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.27812867
74ETS1_21867929_ChIP-Seq_TH2_Mouse1.27739059
75NCOR1_26117541_ChIP-Seq_K562_Human1.26744618
76YY1_22570637_ChIP-Seq_MALME-3M_Human1.24816021
77KDM5A_27292631_Chip-Seq_BREAST_Human1.24774651
78KDM2B_26808549_Chip-Seq_K562_Human1.23808495
79* NOTCH1_21737748_ChIP-Seq_TLL_Human1.21730765
80CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.20955376
81UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.19878961
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17778973
83DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17304256
84TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.17132768
85IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14040243
86CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13106483
87ATF3_27146783_Chip-Seq_COLON_Human1.12257520
88NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.09969681
89RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.09713121
90MYC_18358816_ChIP-ChIP_MESCs_Mouse1.09539297
91CTCF_26484167_Chip-Seq_Bcells_Mouse1.09209312
92ERA_21632823_ChIP-Seq_H3396_Human1.08702426
93POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08196577
94EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08122831
95FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06887157
96SA1_27219007_Chip-Seq_Bcells_Human1.06601991
97MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04405127
98TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02471106
99MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01927312
100RUNX1_22412390_ChIP-Seq_EML_Mouse1.01576599

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity6.17299693
2MP0005171_absent_coat_pigmentation6.08259414
3MP0005423_abnormal_somatic_nervous5.65350164
4MP0005174_abnormal_tail_pigmentation5.51809171
5MP0001188_hyperpigmentation4.12015648
6MP0003136_yellow_coat_color3.61561930
7MP0005409_darkened_coat_color3.32716446
8MP0000015_abnormal_ear_pigmentation3.07308622
9MP0005083_abnormal_biliary_tract2.90315586
10MP0001968_abnormal_touch/_nociception2.51946583
11MP0004381_abnormal_hair_follicle2.42007432
12MP0003111_abnormal_nucleus_morphology2.25996368
13MP0001502_abnormal_circadian_rhythm2.18507286
14MP0005076_abnormal_cell_differentiation2.15005588
15MP0003453_abnormal_keratinocyte_physiol1.89881173
16MP0000751_myopathy1.80009495
17MP0000750_abnormal_muscle_regeneration1.77018061
18MP0008875_abnormal_xenobiotic_pharmacok1.71553908
19MP0001661_extended_life_span1.68241941
20MP0002736_abnormal_nociception_after1.60241662
21MP0005501_abnormal_skin_physiology1.57441303
22MP0001756_abnormal_urination1.55724147
23MP0003077_abnormal_cell_cycle1.55556186
24MP0000538_abnormal_urinary_bladder1.53095596
25MP0009278_abnormal_bone_marrow1.48540654
26MP0003303_peritoneal_inflammation1.48406498
27MP0003693_abnormal_embryo_hatching1.48040789
28MP0002735_abnormal_chemical_nociception1.45097351
29MP0002822_catalepsy1.38422447
30MP0002638_abnormal_pupillary_reflex1.34826073
31MP0002160_abnormal_reproductive_system1.34719692
32MP0000013_abnormal_adipose_tissue1.31546733
33MP0010094_abnormal_chromosome_stability1.28650351
34MP0004130_abnormal_muscle_cell1.22886723
35MP0009840_abnormal_foam_cell1.19480507
36MP0005330_cardiomyopathy1.15448593
37MP0000003_abnormal_adipose_tissue1.15037998
38MP0001348_abnormal_lacrimal_gland1.12105824
39MP0003705_abnormal_hypodermis_morpholog1.10562629
40MP0000358_abnormal_cell_content/1.02721627
41MP0005058_abnormal_lysosome_morphology1.00872749
42MP0001919_abnormal_reproductive_system1.00597635
43MP0002019_abnormal_tumor_incidence0.93744670
44MP0008007_abnormal_cellular_replicative0.89029154
45MP0003329_amyloid_beta_deposits0.87661216
46MP0000678_abnormal_parathyroid_gland0.87076772
47MP0009931_abnormal_skin_appearance0.86710161
48MP0004197_abnormal_fetal_growth/weight/0.86215566
49MP0000367_abnormal_coat/_hair0.83426175
50MP0002249_abnormal_larynx_morphology0.82272902
51MP0000470_abnormal_stomach_morphology0.82268664
52MP0008260_abnormal_autophagy0.80110727
53MP0005451_abnormal_body_composition0.79339091
54MP0003656_abnormal_erythrocyte_physiolo0.78542417
55MP0008874_decreased_physiological_sensi0.78101907
56MP0003091_abnormal_cell_migration0.77782762
57MP0003786_premature_aging0.76692004
58MP0001873_stomach_inflammation0.75737786
59MP0003221_abnormal_cardiomyocyte_apopto0.75477089
60MP0001545_abnormal_hematopoietic_system0.74828002
61MP0005397_hematopoietic_system_phenotyp0.74828002
62MP0005584_abnormal_enzyme/coenzyme_acti0.73487730
63MP0004233_abnormal_muscle_weight0.73105772
64MP0002075_abnormal_coat/hair_pigmentati0.69337558
65MP0001664_abnormal_digestion0.68777387
66MP0001191_abnormal_skin_condition0.68774868
67MP0002210_abnormal_sex_determination0.68654049
68MP0000747_muscle_weakness0.66627282
69MP0001765_abnormal_ion_homeostasis0.66472043
70MP0010771_integument_phenotype0.66466758
71MP0004043_abnormal_pH_regulation0.64066645
72MP0008961_abnormal_basal_metabolism0.63457071
73MP0008995_early_reproductive_senescence0.62915447
74MP0005332_abnormal_amino_acid0.62433841
75MP0000313_abnormal_cell_death0.59991538
76MP0004957_abnormal_blastocyst_morpholog0.59985342
77MP0005220_abnormal_exocrine_pancreas0.59899823
78MP0003763_abnormal_thymus_physiology0.59394470
79MP0003635_abnormal_synaptic_transmissio0.58874219
80MP0001346_abnormal_lacrimal_gland0.58831719
81MP0005621_abnormal_cell_physiology0.58363597
82MP0009333_abnormal_splenocyte_physiolog0.56357447
83MP0006035_abnormal_mitochondrial_morpho0.54551959
84MP0001324_abnormal_eye_pigmentation0.54410874
85MP0001970_abnormal_pain_threshold0.54371151
86MP0002398_abnormal_bone_marrow0.54315380
87MP0005389_reproductive_system_phenotype0.53752027
88MP0000703_abnormal_thymus_morphology0.52654006
89MP0005551_abnormal_eye_electrophysiolog0.51441508
90MP0002080_prenatal_lethality0.51248677
91MP0000371_diluted_coat_color0.50940525
92MP0004811_abnormal_neuron_physiology0.50849638
93MP0001186_pigmentation_phenotype0.49336333
94MP0002095_abnormal_skin_pigmentation0.47870040
95MP0002722_abnormal_immune_system0.47679072
96MP0005384_cellular_phenotype0.47294885
97MP0008058_abnormal_DNA_repair0.47197300
98MP0008057_abnormal_DNA_replication0.46988729
99MP0005410_abnormal_fertilization0.45709219
100MP0002909_abnormal_adrenal_gland0.44861180

Predicted human phenotypes

RankGene SetZ-score
1Testicular atrophy (HP:0000029)6.69381927
2Rib fusion (HP:0000902)5.65725259
3Poikiloderma (HP:0001029)5.64350317
4Thin bony cortex (HP:0002753)5.12562468
5Facial hemangioma (HP:0000329)4.79160310
6Intestinal fistula (HP:0100819)4.75821455
7Annular pancreas (HP:0001734)4.72885962
8Rectal fistula (HP:0100590)4.71138734
9Rectovaginal fistula (HP:0000143)4.71138734
10Vaginal fistula (HP:0004320)4.51585306
11Dyschromatopsia (HP:0007641)4.48382829
12Ulnar bowing (HP:0003031)4.45851579
13Attenuation of retinal blood vessels (HP:0007843)4.35533477
14Squamous cell carcinoma (HP:0002860)4.33158041
15Abnormality of the intrinsic pathway (HP:0010989)4.02485588
16Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.98599280
17Akinesia (HP:0002304)3.91379432
18Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.84003650
19Hemorrhage of the eye (HP:0011885)3.77450938
20Mesangial abnormality (HP:0001966)3.74441554
21Anteriorly placed anus (HP:0001545)3.69871856
22Aplasia of the musculature (HP:0100854)3.68188112
23Turricephaly (HP:0000262)3.66727466
24Patellar aplasia (HP:0006443)3.57966325
25Facial diplegia (HP:0001349)3.39348644
26Aplasia/Hypoplasia of the patella (HP:0006498)3.35817785
27Popliteal pterygium (HP:0009756)3.33518134
28Bony spicule pigmentary retinopathy (HP:0007737)3.27362574
29Short chin (HP:0000331)3.24104502
30Delayed epiphyseal ossification (HP:0002663)3.22028873
31Fetal akinesia sequence (HP:0001989)3.17753133
32Capillary hemangiomas (HP:0005306)3.05240434
33Prolonged partial thromboplastin time (HP:0003645)3.00426068
34Birth length less than 3rd percentile (HP:0003561)2.99815178
35Joint hemorrhage (HP:0005261)2.99251129
36Congenital stationary night blindness (HP:0007642)2.93606656
37Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.93145433
38Enlarged epiphyses (HP:0010580)2.80704089
39Renal Fanconi syndrome (HP:0001994)2.80316511
40Basal cell carcinoma (HP:0002671)2.78888983
41Coronal craniosynostosis (HP:0004440)2.73591689
42Decreased electroretinogram (ERG) amplitude (HP:0000654)2.72798996
43Abnormal albumin level (HP:0012116)2.72146015
44Hypoalbuminemia (HP:0003073)2.72146015
45Choroideremia (HP:0001139)2.61730490
46Premature graying of hair (HP:0002216)2.58433484
47Increased number of teeth (HP:0011069)2.54378679
48Flat occiput (HP:0005469)2.54346970
49Chorioretinal atrophy (HP:0000533)2.52941072
50Hypophosphatemic rickets (HP:0004912)2.51375117
51Increased hepatocellular lipid droplets (HP:0006565)2.50939291
52Atrioventricular block (HP:0001678)2.49908251
53Narrow nasal bridge (HP:0000446)2.49770264
54Abnormality of the costochondral junction (HP:0000919)2.48814462
55Amniotic constriction ring (HP:0009775)2.48245833
56Abnormality of placental membranes (HP:0011409)2.48245833
57Hypoplasia of the pons (HP:0012110)2.48042326
58Neonatal respiratory distress (HP:0002643)2.43572507
59Breast hypoplasia (HP:0003187)2.42870589
60Lipid accumulation in hepatocytes (HP:0006561)2.38910858
61Increased intramyocellular lipid droplets (HP:0012240)2.38464841
62Joint stiffness (HP:0001387)2.35973832
63Decreased central vision (HP:0007663)2.31827560
64Myotonia (HP:0002486)2.29417816
65Increased muscle lipid content (HP:0009058)2.29391709
66Male infertility (HP:0003251)2.25939993
67Widely patent fontanelles and sutures (HP:0004492)2.20835119
68Spina bifida occulta (HP:0003298)2.20615525
69Neonatal onset (HP:0003623)2.20550033
70Abnormality of the pons (HP:0007361)2.17736047
71Bowing of the arm (HP:0006488)2.16841117
72Bowed forearm bones (HP:0003956)2.16841117
73Cheilitis (HP:0100825)2.15885589
74Short humerus (HP:0005792)2.08527111
75Progressive external ophthalmoplegia (HP:0000590)2.08164274
76Progressive muscle weakness (HP:0003323)2.07386883
77Aplasia/Hypoplasia involving the musculature (HP:0001460)2.06744406
78Absent thumb (HP:0009777)2.00589053
79Absent radius (HP:0003974)2.00076433
80Rectal prolapse (HP:0002035)1.98018402
81Progressive microcephaly (HP:0000253)1.95598371
82Cholelithiasis (HP:0001081)1.93397271
83Myopathic facies (HP:0002058)1.92331624
84Abnormal epiphyseal ossification (HP:0010656)1.91571223
85Thin ribs (HP:0000883)1.91465452
86Absent forearm bone (HP:0003953)1.89526561
87Aplasia involving forearm bones (HP:0009822)1.89526561
88Diminished movement (HP:0002374)1.87289605
89Aplasia/hypoplasia of the humerus (HP:0006507)1.84478301
90Lip pit (HP:0100267)1.80687005
91Short thumb (HP:0009778)1.78960108
92Choanal stenosis (HP:0000452)1.77409425
93Microvesicular hepatic steatosis (HP:0001414)1.76843863
94Zonular cataract (HP:0010920)1.76446182
95Respiratory difficulties (HP:0002880)1.76221769
96Cystic hygroma (HP:0000476)1.75583251
97External ophthalmoplegia (HP:0000544)1.73240853
98Abnormal trabecular bone morphology (HP:0100671)1.72896870
99Abnormality of the fingertips (HP:0001211)1.70686422
100Hypoplasia of the radius (HP:0002984)1.67910135

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK156.61384069
2TLK13.34887691
3TESK23.34442198
4TAOK32.86562387
5TRIB32.84415925
6CDK122.81082321
7SIK22.58693550
8PIM22.56208556
9SMG12.45142812
10WNK42.33583797
11BLK2.19517458
12SIK12.04039383
13ERN12.00035480
14EEF2K1.98705017
15MAP2K31.93484376
16GRK61.81914785
17IRAK31.78261523
18PRPF4B1.68528743
19IRAK21.58662863
20ICK1.45377598
21CDK41.44792850
22MUSK1.42329307
23DYRK1B1.39913365
24MAP4K11.32017235
25RAF11.29910017
26TBK11.23708427
27MARK21.20857776
28PRKD21.20265669
29MAP3K111.18418145
30ZAK1.14347806
31AURKA1.10918643
32CDK61.06253001
33MAPK111.04564509
34STK160.98549596
35MTOR0.97840977
36PKN20.96779115
37MAP2K40.94220563
38TNK20.91010275
39BRD40.89834262
40MELK0.86896235
41AKT30.84967946
42PDPK10.83936543
43RPS6KA20.81902896
44TRIM280.79673330
45KSR20.79647153
46IKBKE0.79249874
47SIK30.77841274
48RPS6KA50.75457056
49BMX0.75120368
50CSNK1A1L0.73193773
51ZAP700.72068254
52CAMKK10.70676170
53ARAF0.70033777
54IKBKB0.69573909
55CHEK20.69168807
56MAPK120.68141445
57PIM10.67160624
58CCNB10.66634101
59CSNK1G30.65548951
60ATR0.65505561
61MAP2K70.63883028
62MAP3K60.62104891
63RPS6KA60.61716504
64CDK80.61701346
65RPS6KC10.60648014
66RPS6KL10.60648014
67ADRBK10.58721527
68PKN10.58290124
69NEK60.58256592
70PRKAA10.57964425
71CDK150.56745766
72BCKDK0.55669171
73CDK11A0.54422251
74CHUK0.54243767
75PRKD10.53997257
76MAPK80.53013816
77MAP2K60.52305709
78MAP3K10.50849743
79CDK180.50735962
80EPHA20.50565820
81CAMKK20.46839262
82DYRK30.45565724
83STK110.43391175
84CDK90.42819298
85PRKCI0.42563778
86RET0.41201680
87CSK0.40157877
88HIPK20.39406330
89MAP3K100.39192816
90AKT20.37009557
91BMPR1B0.36605767
92CDK20.35822333
93CSNK1D0.35546792
94RPS6KA10.34092748
95TAOK20.32782569
96CDK140.32079608
97RPS6KB10.31285560
98CSNK1G10.30748548
99PDK20.30635497
100WNK10.29956955

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006045.91434930
2Sulfur relay system_Homo sapiens_hsa041224.93331659
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.55674914
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.08331116
5Fructose and mannose metabolism_Homo sapiens_hsa000512.70142276
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.62203719
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.32853278
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.28870428
9Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.11385104
10Sphingolipid metabolism_Homo sapiens_hsa006001.83611796
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.75647677
12Base excision repair_Homo sapiens_hsa034101.64656126
13Circadian rhythm_Homo sapiens_hsa047101.49098221
14mTOR signaling pathway_Homo sapiens_hsa041501.40955150
15Fanconi anemia pathway_Homo sapiens_hsa034601.40027258
16Bladder cancer_Homo sapiens_hsa052191.37980913
17Nicotine addiction_Homo sapiens_hsa050331.37656018
18Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.33988989
19Alcoholism_Homo sapiens_hsa050341.33970111
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.24155090
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.14064961
22Inositol phosphate metabolism_Homo sapiens_hsa005621.13806514
23Neurotrophin signaling pathway_Homo sapiens_hsa047221.11471532
24Notch signaling pathway_Homo sapiens_hsa043301.09532312
25Lysine degradation_Homo sapiens_hsa003101.09330352
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04982367
27Acute myeloid leukemia_Homo sapiens_hsa052211.04932536
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.03066526
29Non-small cell lung cancer_Homo sapiens_hsa052231.02182551
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.00874412
31VEGF signaling pathway_Homo sapiens_hsa043701.00250908
32Hedgehog signaling pathway_Homo sapiens_hsa043401.00046442
33Longevity regulating pathway - mammal_Homo sapiens_hsa042110.98044741
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97338352
35Systemic lupus erythematosus_Homo sapiens_hsa053220.95662316
36RNA polymerase_Homo sapiens_hsa030200.93797534
37Other glycan degradation_Homo sapiens_hsa005110.92677619
38Cell cycle_Homo sapiens_hsa041100.87514961
39Chronic myeloid leukemia_Homo sapiens_hsa052200.83577180
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80668505
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77518190
42Endometrial cancer_Homo sapiens_hsa052130.75076978
43Apoptosis_Homo sapiens_hsa042100.74591968
44Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74221576
45Taste transduction_Homo sapiens_hsa047420.73294392
46B cell receptor signaling pathway_Homo sapiens_hsa046620.72577320
47Hepatitis C_Homo sapiens_hsa051600.71868023
48Hepatitis B_Homo sapiens_hsa051610.71806816
49Viral carcinogenesis_Homo sapiens_hsa052030.70725207
50mRNA surveillance pathway_Homo sapiens_hsa030150.70468209
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70095096
52Colorectal cancer_Homo sapiens_hsa052100.69394699
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68956606
54Lysosome_Homo sapiens_hsa041420.64619025
55Ovarian steroidogenesis_Homo sapiens_hsa049130.63831273
56Endocytosis_Homo sapiens_hsa041440.63541937
57Basal transcription factors_Homo sapiens_hsa030220.63395810
58Pancreatic cancer_Homo sapiens_hsa052120.63257846
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60565375
60ErbB signaling pathway_Homo sapiens_hsa040120.59172785
61Insulin resistance_Homo sapiens_hsa049310.58757687
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.57788428
63Cocaine addiction_Homo sapiens_hsa050300.57231448
64Melanogenesis_Homo sapiens_hsa049160.55040508
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54980318
66Pyrimidine metabolism_Homo sapiens_hsa002400.52459040
67Hippo signaling pathway_Homo sapiens_hsa043900.52173870
68AMPK signaling pathway_Homo sapiens_hsa041520.50860239
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49112803
70Primary immunodeficiency_Homo sapiens_hsa053400.48424635
71N-Glycan biosynthesis_Homo sapiens_hsa005100.47891675
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.45043745
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.44828153
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44781602
75FoxO signaling pathway_Homo sapiens_hsa040680.44628014
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44412268
77MAPK signaling pathway_Homo sapiens_hsa040100.44339215
78HTLV-I infection_Homo sapiens_hsa051660.42493277
79Cholinergic synapse_Homo sapiens_hsa047250.42319672
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.42154078
81Calcium signaling pathway_Homo sapiens_hsa040200.40357437
82p53 signaling pathway_Homo sapiens_hsa041150.38738827
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.38298615
84Gap junction_Homo sapiens_hsa045400.35958460
85Basal cell carcinoma_Homo sapiens_hsa052170.35772344
86TNF signaling pathway_Homo sapiens_hsa046680.34253267
87Axon guidance_Homo sapiens_hsa043600.33676704
88GnRH signaling pathway_Homo sapiens_hsa049120.33562361
89Insulin signaling pathway_Homo sapiens_hsa049100.31828171
90Glioma_Homo sapiens_hsa052140.31703535
91Biosynthesis of amino acids_Homo sapiens_hsa012300.31326857
92RNA transport_Homo sapiens_hsa030130.30128083
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29914445
94Epstein-Barr virus infection_Homo sapiens_hsa051690.29839406
95Herpes simplex infection_Homo sapiens_hsa051680.29636768
96T cell receptor signaling pathway_Homo sapiens_hsa046600.29495576
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28713509
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27823792
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26748657
100Influenza A_Homo sapiens_hsa051640.26694096

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