ZNF322P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of helicase activity (GO:0051095)4.91376590
2somatic hypermutation of immunoglobulin genes (GO:0016446)4.55027738
3somatic diversification of immune receptors via somatic mutation (GO:0002566)4.55027738
4protein-cofactor linkage (GO:0018065)4.24063586
5DNA double-strand break processing (GO:0000729)4.19015376
6UDP-N-acetylglucosamine metabolic process (GO:0006047)3.87945514
7negative regulation of DNA-dependent DNA replication (GO:2000104)3.83730289
8cullin deneddylation (GO:0010388)3.77789038
9platelet dense granule organization (GO:0060155)3.68426086
10regulation of hexokinase activity (GO:1903299)3.62922500
11regulation of glucokinase activity (GO:0033131)3.62922500
12regulation of nuclear cell cycle DNA replication (GO:0033262)3.57833540
13behavioral response to nicotine (GO:0035095)3.48884491
14response to pheromone (GO:0019236)3.46147096
15regulation of mitotic spindle checkpoint (GO:1903504)3.35461566
16regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.35461566
17water-soluble vitamin biosynthetic process (GO:0042364)3.34733610
18resolution of meiotic recombination intermediates (GO:0000712)3.33298754
19regulation of DNA endoreduplication (GO:0032875)3.28023589
20synapsis (GO:0007129)3.25693372
21protein deneddylation (GO:0000338)3.25686241
22regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.20115464
23negative regulation of DNA recombination (GO:0045910)3.18341494
24presynaptic membrane assembly (GO:0097105)3.16108168
25female gonad development (GO:0008585)3.14557954
26positive regulation of oligodendrocyte differentiation (GO:0048714)3.12837037
27mannosylation (GO:0097502)3.10007447
28proteasome assembly (GO:0043248)3.08421391
29nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.04843196
30establishment of protein localization to mitochondrial membrane (GO:0090151)3.00612775
31DNA replication-dependent nucleosome assembly (GO:0006335)3.00210643
32DNA replication-dependent nucleosome organization (GO:0034723)3.00210643
33regulation of non-canonical Wnt signaling pathway (GO:2000050)2.99601050
34exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.97845049
35ventricular cardiac muscle cell development (GO:0055015)2.91976283
36rRNA methylation (GO:0031167)2.89973158
37nephron epithelium morphogenesis (GO:0072088)2.88108422
38nephron tubule morphogenesis (GO:0072078)2.88108422
39somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.87624869
40somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.87624869
41isotype switching (GO:0045190)2.87624869
42prenylation (GO:0097354)2.87112750
43protein prenylation (GO:0018342)2.87112750
44kidney morphogenesis (GO:0060993)2.86686337
45DNA damage response, detection of DNA damage (GO:0042769)2.85995959
46chromatin remodeling at centromere (GO:0031055)2.84403761
47DNA catabolic process, exonucleolytic (GO:0000738)2.84050966
48pyrimidine nucleobase catabolic process (GO:0006208)2.77628375
49mismatch repair (GO:0006298)2.76836071
50rRNA modification (GO:0000154)2.76649334
51CENP-A containing nucleosome assembly (GO:0034080)2.75450021
52double-strand break repair via homologous recombination (GO:0000724)2.69485719
53recombinational repair (GO:0000725)2.69057754
54receptor guanylyl cyclase signaling pathway (GO:0007168)2.67678889
55lactate metabolic process (GO:0006089)2.65638343
56anterograde synaptic vesicle transport (GO:0048490)2.65544584
57regulation of meiosis I (GO:0060631)2.64502470
58L-fucose catabolic process (GO:0042355)2.62553548
59fucose catabolic process (GO:0019317)2.62553548
60L-fucose metabolic process (GO:0042354)2.62553548
61preassembly of GPI anchor in ER membrane (GO:0016254)2.62306090
62dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.62151759
63somatic diversification of immunoglobulins (GO:0016445)2.56354519
64aspartate family amino acid catabolic process (GO:0009068)2.54881729
65RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.53999096
66regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.51175141
67somatic recombination of immunoglobulin gene segments (GO:0016447)2.50480532
68peptidyl-histidine modification (GO:0018202)2.49937996
69photoreceptor cell maintenance (GO:0045494)2.48602216
70branched-chain amino acid catabolic process (GO:0009083)2.47995899
71presynaptic membrane organization (GO:0097090)2.47979647
72transcription elongation from RNA polymerase I promoter (GO:0006362)2.46871727
73protein K6-linked ubiquitination (GO:0085020)2.46604912
74histone exchange (GO:0043486)2.45856929
75tRNA modification (GO:0006400)2.44217979
76maturation of 5.8S rRNA (GO:0000460)2.44097932
77detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.43878670
78somite rostral/caudal axis specification (GO:0032525)2.43163404
79pre-miRNA processing (GO:0031054)2.41366080
80histone H2A acetylation (GO:0043968)2.40506916
81regulation of centriole replication (GO:0046599)2.40276428
82DNA replication checkpoint (GO:0000076)2.39358466
83nucleotide-sugar biosynthetic process (GO:0009226)2.37759757
84aggressive behavior (GO:0002118)2.36901451
85ncRNA catabolic process (GO:0034661)2.36725790
86reciprocal meiotic recombination (GO:0007131)2.34540774
87reciprocal DNA recombination (GO:0035825)2.34540774
88lysine catabolic process (GO:0006554)2.33082560
89lysine metabolic process (GO:0006553)2.33082560
90regulation of mesoderm development (GO:2000380)2.32917057
91male meiosis (GO:0007140)2.31803894
92nucleobase catabolic process (GO:0046113)2.31267438
93GPI anchor metabolic process (GO:0006505)2.30589708
94ribonucleoprotein complex disassembly (GO:0032988)2.28531514
95regulation of telomere maintenance via telomerase (GO:0032210)2.27717870
96regulation of acyl-CoA biosynthetic process (GO:0050812)2.25037803
97intraciliary transport (GO:0042073)2.24394164
98pituitary gland development (GO:0021983)2.24363269
99atrial cardiac muscle cell action potential (GO:0086014)2.23921553
100tRNA processing (GO:0008033)2.21399103

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.63336361
2ZNF274_21170338_ChIP-Seq_K562_Hela3.50263740
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.08012663
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.07023805
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.94427105
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.63765307
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.55031885
8FUS_26573619_Chip-Seq_HEK293_Human2.51872278
9GBX2_23144817_ChIP-Seq_PC3_Human2.51691670
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.50326875
11EWS_26573619_Chip-Seq_HEK293_Human2.48337079
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.35533823
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.35015788
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.27231937
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.26199115
16P300_19829295_ChIP-Seq_ESCs_Human2.25199206
17ELK1_19687146_ChIP-ChIP_HELA_Human2.24862334
18TAF15_26573619_Chip-Seq_HEK293_Human2.24589776
19VDR_22108803_ChIP-Seq_LS180_Human2.16228971
20POU5F1_16153702_ChIP-ChIP_HESCs_Human2.15815140
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09650252
22IGF1R_20145208_ChIP-Seq_DFB_Human2.07939841
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.05483441
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.05075555
25E2F4_17652178_ChIP-ChIP_JURKAT_Human1.89628816
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68524906
27RBPJ_22232070_ChIP-Seq_NCS_Mouse1.66875047
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65454975
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.64717877
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63567454
31E2F7_22180533_ChIP-Seq_HELA_Human1.62896331
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58104773
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.56933854
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.56185632
35VDR_23849224_ChIP-Seq_CD4+_Human1.50773192
36MYC_18940864_ChIP-ChIP_HL60_Human1.48179740
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.46668173
38KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46652068
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.45858424
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45275916
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44279627
42SMAD4_21799915_ChIP-Seq_A2780_Human1.43991000
43NANOG_16153702_ChIP-ChIP_HESCs_Human1.43977325
44ER_23166858_ChIP-Seq_MCF-7_Human1.43850544
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.41635074
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40640703
47SOX2_16153702_ChIP-ChIP_HESCs_Human1.40108566
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.38750974
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32784446
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30456993
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26095048
52RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.25954681
53GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25118030
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.24251011
55NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.22723572
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.22527353
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19870652
58JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.19860578
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19686615
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18766618
61ETS1_20019798_ChIP-Seq_JURKAT_Human1.18499241
62KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17638585
63RNF2_27304074_Chip-Seq_NSC_Mouse1.15109269
64SOX2_19829295_ChIP-Seq_ESCs_Human1.14509374
65NANOG_19829295_ChIP-Seq_ESCs_Human1.14509374
66BCAT_22108803_ChIP-Seq_LS180_Human1.14015756
67TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.13702085
68CBP_20019798_ChIP-Seq_JUKART_Human1.12460976
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12460976
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12260965
71FOXP3_21729870_ChIP-Seq_TREG_Human1.11849201
72AR_25329375_ChIP-Seq_VCAP_Human1.11834307
73IRF1_19129219_ChIP-ChIP_H3396_Human1.11175971
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10905174
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.10890300
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10834380
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.10567440
78FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10425143
79STAT3_23295773_ChIP-Seq_U87_Human1.09792707
80FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.09660321
81TCF4_22108803_ChIP-Seq_LS180_Human1.08590674
82YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07126132
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07037832
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07025505
85PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05611645
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04940444
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04940444
88TP53_22573176_ChIP-Seq_HFKS_Human1.01828931
89TCF4_23295773_ChIP-Seq_U87_Human1.01658366
90SRF_21415370_ChIP-Seq_HL-1_Mouse1.01527566
91MYC_18555785_ChIP-Seq_MESCs_Mouse1.01084132
92ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00428156
93CRX_20693478_ChIP-Seq_RETINA_Mouse0.99930207
94CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99493526
95KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99222447
96CDX2_22108803_ChIP-Seq_LS180_Human0.99061936
97FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98233913
98RUNX2_22187159_ChIP-Seq_PCA_Human0.98112548
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97798295
100TBX3_20139965_ChIP-Seq_ESCs_Mouse0.94292467

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology4.19422724
2MP0008877_abnormal_DNA_methylation3.51832989
3MP0003890_abnormal_embryonic-extraembry2.90347849
4MP0003136_yellow_coat_color2.55308779
5MP0006072_abnormal_retinal_apoptosis2.41151808
6MP0003122_maternal_imprinting2.28420909
7MP0002837_dystrophic_cardiac_calcinosis2.20134422
8MP0002938_white_spotting2.02907956
9MP0003787_abnormal_imprinting1.98505109
10MP0004133_heterotaxia1.96527480
11MP0003937_abnormal_limbs/digits/tail_de1.88542816
12MP0006292_abnormal_olfactory_placode1.88242075
13MP0001293_anophthalmia1.86209607
14MP0003011_delayed_dark_adaptation1.84176310
15MP0005551_abnormal_eye_electrophysiolog1.78469164
16MP0003195_calcinosis1.78143336
17MP0005253_abnormal_eye_physiology1.77680524
18MP0003121_genomic_imprinting1.75516929
19MP0003941_abnormal_skin_development1.73964192
20MP0002751_abnormal_autonomic_nervous1.70594058
21MP0003693_abnormal_embryo_hatching1.67408082
22MP0004957_abnormal_blastocyst_morpholog1.62473922
23MP0008007_abnormal_cellular_replicative1.62290121
24MP0008058_abnormal_DNA_repair1.61722688
25MP0002139_abnormal_hepatobiliary_system1.61282635
26MP0003137_abnormal_impulse_conducting1.60796110
27MP0000647_abnormal_sebaceous_gland1.53138397
28MP0000631_abnormal_neuroendocrine_gland1.51884645
29MP0003718_maternal_effect1.51584001
30MP0002254_reproductive_system_inflammat1.50661365
31MP0008057_abnormal_DNA_replication1.49056045
32MP0004142_abnormal_muscle_tone1.48318500
33MP0003119_abnormal_digestive_system1.47099892
34MP0010094_abnormal_chromosome_stability1.41469565
35MP0009046_muscle_twitch1.40999280
36MP0001485_abnormal_pinna_reflex1.39964782
37MP0002090_abnormal_vision1.31745420
38MP0001286_abnormal_eye_development1.31638072
39MP0009697_abnormal_copulation1.31050163
40MP0003567_abnormal_fetal_cardiomyocyte1.28582150
41MP0000372_irregular_coat_pigmentation1.27410533
42MP0002638_abnormal_pupillary_reflex1.26003282
43MP0003880_abnormal_central_pattern1.21271972
44MP0010030_abnormal_orbit_morphology1.18914600
45MP0002736_abnormal_nociception_after1.18521558
46MP0005084_abnormal_gallbladder_morpholo1.18487785
47MP0005646_abnormal_pituitary_gland1.16017568
48MP0001984_abnormal_olfaction1.15278150
49MP0003186_abnormal_redox_activity1.11191878
50MP0001486_abnormal_startle_reflex1.09146023
51MP0005377_hearing/vestibular/ear_phenot1.08622069
52MP0003878_abnormal_ear_physiology1.08622069
53MP0003077_abnormal_cell_cycle1.08094994
54MP0003786_premature_aging1.04739786
55MP0006276_abnormal_autonomic_nervous1.03925622
56MP0005187_abnormal_penis_morphology1.02343336
57MP0002272_abnormal_nervous_system1.01654750
58MP0010234_abnormal_vibrissa_follicle1.01527401
59MP0002138_abnormal_hepatobiliary_system1.00952798
60MP0004147_increased_porphyrin_level0.99917427
61MP0002557_abnormal_social/conspecific_i0.98412300
62MP0003111_abnormal_nucleus_morphology0.96305581
63MP0005391_vision/eye_phenotype0.95996756
64MP0004145_abnormal_muscle_electrophysio0.95070056
65MP0001177_atelectasis0.94048939
66MP0002084_abnormal_developmental_patter0.93543014
67MP0010678_abnormal_skin_adnexa0.92953370
68MP0005379_endocrine/exocrine_gland_phen0.92867240
69MP0001324_abnormal_eye_pigmentation0.91292603
70MP0000516_abnormal_urinary_system0.91239876
71MP0005367_renal/urinary_system_phenotyp0.91239876
72MP0004215_abnormal_myocardial_fiber0.90953004
73MP0005171_absent_coat_pigmentation0.90449724
74MP0009703_decreased_birth_body0.90218780
75MP0009745_abnormal_behavioral_response0.89593712
76MP0001929_abnormal_gametogenesis0.89494878
77MP0002697_abnormal_eye_size0.89225716
78MP0001529_abnormal_vocalization0.89211818
79MP0008932_abnormal_embryonic_tissue0.87637016
80MP0005332_abnormal_amino_acid0.86973059
81MP0000653_abnormal_sex_gland0.86444980
82MP0003755_abnormal_palate_morphology0.86179450
83MP0002210_abnormal_sex_determination0.86005206
84MP0006035_abnormal_mitochondrial_morpho0.83498909
85MP0000049_abnormal_middle_ear0.83116015
86MP0000383_abnormal_hair_follicle0.81863748
87MP0005394_taste/olfaction_phenotype0.81471963
88MP0005499_abnormal_olfactory_system0.81471963
89MP0004742_abnormal_vestibular_system0.80425599
90MP0001145_abnormal_male_reproductive0.79111319
91MP0002752_abnormal_somatic_nervous0.78144148
92MP0002184_abnormal_innervation0.77478046
93MP0005408_hypopigmentation0.77022060
94MP0008995_early_reproductive_senescence0.76692008
95MP0000778_abnormal_nervous_system0.73907954
96MP0010307_abnormal_tumor_latency0.73648157
97MP0005075_abnormal_melanosome_morpholog0.72775683
98MP0002111_abnormal_tail_morphology0.72507916
99MP0005195_abnormal_posterior_eye0.72461895
100MP0002282_abnormal_trachea_morphology0.71984278

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.69288283
2Neoplasm of the adrenal cortex (HP:0100641)4.10579117
3Astrocytoma (HP:0009592)3.41626162
4Abnormality of the astrocytes (HP:0100707)3.41626162
5Focal motor seizures (HP:0011153)3.41227332
6Glioma (HP:0009733)3.37494666
7Neoplasm of the adrenal gland (HP:0100631)3.18326030
8Pancreatic fibrosis (HP:0100732)3.18282464
9Decreased central vision (HP:0007663)2.95465737
10Abnormality of aspartate family amino acid metabolism (HP:0010899)2.89509134
11Short tibia (HP:0005736)2.85043826
12Pancreatic cysts (HP:0001737)2.84807417
13True hermaphroditism (HP:0010459)2.77629260
14Increased corneal curvature (HP:0100692)2.73344184
15Keratoconus (HP:0000563)2.73344184
16Pendular nystagmus (HP:0012043)2.70325949
17Agnosia (HP:0010524)2.70278866
18Abnormality of serum amino acid levels (HP:0003112)2.69631995
19Aplasia/Hypoplasia of the tibia (HP:0005772)2.68162821
20Hyperglycinemia (HP:0002154)2.62500112
21Abnormality of midbrain morphology (HP:0002418)2.59343319
22Molar tooth sign on MRI (HP:0002419)2.59343319
23Angiofibromas (HP:0010615)2.56499510
24Adenoma sebaceum (HP:0009720)2.56499510
25Medulloblastoma (HP:0002885)2.55814785
26Abnormal pancreas size (HP:0012094)2.54016387
27Rhabdomyosarcoma (HP:0002859)2.51994897
28Abolished electroretinogram (ERG) (HP:0000550)2.50743775
29Chronic hepatic failure (HP:0100626)2.50175853
30Dialeptic seizures (HP:0011146)2.48304758
31Decreased electroretinogram (ERG) amplitude (HP:0000654)2.45255598
32Nephronophthisis (HP:0000090)2.43351761
33Type II lissencephaly (HP:0007260)2.42697619
34Methylmalonic acidemia (HP:0002912)2.40918305
35Adrenal hypoplasia (HP:0000835)2.40659563
36Abnormality of the proximal phalanges of the hand (HP:0009834)2.38621359
37Abnormality of the labia minora (HP:0012880)2.36901355
38Hypoplasia of the uterus (HP:0000013)2.32936342
39Focal seizures (HP:0007359)2.31750139
40Colon cancer (HP:0003003)2.30738995
41Aplasia/hypoplasia of the uterus (HP:0008684)2.29955965
42Intestinal atresia (HP:0011100)2.27173702
43Acute encephalopathy (HP:0006846)2.23643275
44Abnormality of glycine metabolism (HP:0010895)2.23587477
45Abnormality of serine family amino acid metabolism (HP:0010894)2.23587477
46Increased hepatocellular lipid droplets (HP:0006565)2.19371166
47Hyperglycinuria (HP:0003108)2.16857021
48Lipid accumulation in hepatocytes (HP:0006561)2.16724396
49Neoplasm of striated muscle (HP:0009728)2.12119776
50Methylmalonic aciduria (HP:0012120)2.10087165
51Absent rod-and cone-mediated responses on ERG (HP:0007688)2.08128870
52Supernumerary spleens (HP:0009799)2.06851656
533-Methylglutaconic aciduria (HP:0003535)2.06352214
54Aplasia/Hypoplasia of the tongue (HP:0010295)2.04703536
55Neoplasm of the colon (HP:0100273)2.04593828
56Proximal tubulopathy (HP:0000114)2.04257508
57Dandy-Walker malformation (HP:0001305)2.03933868
58Increased CSF lactate (HP:0002490)2.03506105
59Abnormality of the phalanges of the 2nd finger (HP:0009541)1.99985372
60Hemiparesis (HP:0001269)1.98171639
61Abnormal lung lobation (HP:0002101)1.96390666
62Abnormality of the renal medulla (HP:0100957)1.96206436
63Absence seizures (HP:0002121)1.95902405
64Neoplasm of the oral cavity (HP:0100649)1.94612442
65Glycosuria (HP:0003076)1.93441255
66Abnormality of urine glucose concentration (HP:0011016)1.93441255
67Abnormality of the middle phalanges of the toes (HP:0010183)1.89213368
68Meckel diverticulum (HP:0002245)1.88280099
69Abnormality of vitamin B metabolism (HP:0004340)1.88193555
70Abnormality of the ileum (HP:0001549)1.87580010
71Bile duct proliferation (HP:0001408)1.85899934
72Abnormal biliary tract physiology (HP:0012439)1.85899934
73Biliary tract neoplasm (HP:0100574)1.85852680
74Abnormal rod and cone electroretinograms (HP:0008323)1.83237319
75Acute necrotizing encephalopathy (HP:0006965)1.82821183
76Tubular atrophy (HP:0000092)1.82536931
77Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.82504536
78Abnormality of the phalanges of the 5th finger (HP:0004213)1.81288868
79Medial flaring of the eyebrow (HP:0010747)1.80438729
80Hamartoma of the eye (HP:0010568)1.80043317
81Abnormality of the vitamin B12 metabolism (HP:0004341)1.79727602
82Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.79454747
83Chorioretinal atrophy (HP:0000533)1.79400097
84Cystic liver disease (HP:0006706)1.78646295
85Benign neoplasm of the central nervous system (HP:0100835)1.77899827
86Hypoglycemic coma (HP:0001325)1.77129537
87Cerebellar dysplasia (HP:0007033)1.77105977
88Optic nerve hypoplasia (HP:0000609)1.77088339
89Aplasia/Hypoplasia of the uvula (HP:0010293)1.76370521
90Neoplasm of the small intestine (HP:0100833)1.76226857
91Atonic seizures (HP:0010819)1.76181405
92Degeneration of anterior horn cells (HP:0002398)1.75000670
93Abnormality of the anterior horn cell (HP:0006802)1.75000670
94Occipital encephalocele (HP:0002085)1.74925399
95Gastrointestinal atresia (HP:0002589)1.74797849
96Preaxial hand polydactyly (HP:0001177)1.71849045
97Renal hypoplasia (HP:0000089)1.70944584
98Abnormality of the renal cortex (HP:0011035)1.70913069
99Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.70689606
100Degeneration of the lateral corticospinal tracts (HP:0002314)1.70689606

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK3.41633892
2ZAK3.26926923
3MKNK22.90579587
4EIF2AK32.64322933
5NUAK12.58030689
6VRK22.49017418
7FRK2.44308972
8TRIM282.36509750
9ACVR1B2.32942478
10MKNK12.26958350
11WNK32.24005127
12BUB12.19976878
13STK392.06840034
14WEE11.95839633
15MST41.87984492
16BMPR1B1.83917752
17OXSR11.79916100
18MAP4K21.70160330
19WNK41.69803172
20DYRK31.68337887
21PLK31.65417260
22STK161.62023770
23CDC71.59831731
24CSNK1G11.48887749
25CSNK1G21.46822290
26BCR1.46621246
27TSSK61.41088139
28PLK21.39657372
29TNIK1.39586546
30CASK1.37865188
31GRK11.36429775
32VRK11.32419239
33ERBB31.32176615
34EPHA31.27321958
35CSNK1G31.23459042
36PLK41.23382129
37SRPK11.23287437
38CAMK1G1.23217317
39RPS6KA41.17005117
40FER1.15526775
41PRKCE1.10392192
42PLK11.01836278
43PINK11.00691547
44CSNK1A1L1.00288999
45PAK40.98273155
46TLK10.95504207
47PHKG10.93628198
48PHKG20.93628198
49NEK10.93264111
50TAF10.92260209
51NME10.90395246
52FGFR20.89246417
53ATR0.88614681
54NLK0.86273795
55PAK30.85527972
56TIE10.85366703
57PBK0.84560513
58TTK0.84290790
59ADRBK20.83419762
60DYRK20.80131200
61EIF2AK10.78186334
62PRKCG0.77850335
63BRSK20.71643168
64ERBB40.70520572
65MAPK130.69207649
66MAP3K40.68905355
67FLT30.68138843
68STK38L0.66076428
69NTRK30.60855306
70ATM0.60783213
71EIF2AK20.60602159
72MINK10.60348489
73MAP3K90.57042213
74STK240.54977626
75RPS6KA50.54812810
76CSNK1D0.46806397
77BCKDK0.46782664
78RAF10.46261640
79CDK30.45980370
80PDK20.45340516
81INSRR0.45281871
82BRD40.44268409
83NEK20.44158995
84CAMK2A0.42155814
85SIK30.42088019
86PIM10.40979560
87TGFBR10.40184829
88CSNK1A10.39781242
89FGFR10.35613671
90PRKCI0.34809895
91PIK3CA0.34655352
92MET0.33945497
93LIMK10.33204458
94OBSCN0.32486581
95CHEK20.31297116
96CDK90.29860032
97CSNK2A10.29663365
98CAMK2D0.29049234
99GRK50.26797781
100DAPK30.26739771

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030602.81440195
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.68514213
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.52491395
4Proteasome_Homo sapiens_hsa030502.44129628
5Propanoate metabolism_Homo sapiens_hsa006402.38418903
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.29547734
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.28587193
8Mismatch repair_Homo sapiens_hsa034302.21895282
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.18954415
10Phototransduction_Homo sapiens_hsa047442.10681615
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.08223039
12Steroid biosynthesis_Homo sapiens_hsa001002.05303515
13Butanoate metabolism_Homo sapiens_hsa006501.98987004
14Selenocompound metabolism_Homo sapiens_hsa004501.96651600
15RNA degradation_Homo sapiens_hsa030181.88760450
16RNA polymerase_Homo sapiens_hsa030201.84650163
17Non-homologous end-joining_Homo sapiens_hsa034501.77569985
18One carbon pool by folate_Homo sapiens_hsa006701.69459448
19RNA transport_Homo sapiens_hsa030131.67459062
20Fatty acid elongation_Homo sapiens_hsa000621.62934934
21Homologous recombination_Homo sapiens_hsa034401.62496397
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.60777976
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.57496513
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.55504852
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.54241921
26Sulfur metabolism_Homo sapiens_hsa009201.53455556
27Oxidative phosphorylation_Homo sapiens_hsa001901.50500758
28Fanconi anemia pathway_Homo sapiens_hsa034601.48995876
29Vitamin B6 metabolism_Homo sapiens_hsa007501.45578340
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.42253093
31Nicotine addiction_Homo sapiens_hsa050331.41334872
32Basal transcription factors_Homo sapiens_hsa030221.37589924
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35588028
34Parkinsons disease_Homo sapiens_hsa050121.34166036
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.23678406
36Spliceosome_Homo sapiens_hsa030401.23406501
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.22999832
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.18369803
39Huntingtons disease_Homo sapiens_hsa050161.14244929
40Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.12013618
41Pyruvate metabolism_Homo sapiens_hsa006201.10898023
42Glutathione metabolism_Homo sapiens_hsa004801.06658980
43DNA replication_Homo sapiens_hsa030301.04927448
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04788045
45Nitrogen metabolism_Homo sapiens_hsa009101.02639071
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02208430
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99686534
48Taste transduction_Homo sapiens_hsa047420.99167210
49Oocyte meiosis_Homo sapiens_hsa041140.97648547
50Ether lipid metabolism_Homo sapiens_hsa005650.92261958
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91304863
52Pentose and glucuronate interconversions_Homo sapiens_hsa000400.91167590
53Peroxisome_Homo sapiens_hsa041460.89085261
54Systemic lupus erythematosus_Homo sapiens_hsa053220.88254356
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87701593
56Nucleotide excision repair_Homo sapiens_hsa034200.85745649
57Fat digestion and absorption_Homo sapiens_hsa049750.84802924
58Retinol metabolism_Homo sapiens_hsa008300.84572435
59Cell cycle_Homo sapiens_hsa041100.83912907
60p53 signaling pathway_Homo sapiens_hsa041150.82830504
61Linoleic acid metabolism_Homo sapiens_hsa005910.82828856
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82628562
63Purine metabolism_Homo sapiens_hsa002300.81387694
64Fatty acid metabolism_Homo sapiens_hsa012120.81114410
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78907617
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78486950
67Alzheimers disease_Homo sapiens_hsa050100.77757024
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77406574
69Olfactory transduction_Homo sapiens_hsa047400.74397832
70TGF-beta signaling pathway_Homo sapiens_hsa043500.74332424
71Chemical carcinogenesis_Homo sapiens_hsa052040.73939271
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72940613
73Tryptophan metabolism_Homo sapiens_hsa003800.72855421
74Alcoholism_Homo sapiens_hsa050340.71840388
75beta-Alanine metabolism_Homo sapiens_hsa004100.70320150
76Pyrimidine metabolism_Homo sapiens_hsa002400.67962472
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67775638
78Metabolic pathways_Homo sapiens_hsa011000.67503744
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.67033087
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66263757
81Carbon metabolism_Homo sapiens_hsa012000.65675706
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65474801
83Hedgehog signaling pathway_Homo sapiens_hsa043400.64991222
84Vitamin digestion and absorption_Homo sapiens_hsa049770.62637744
85Fatty acid degradation_Homo sapiens_hsa000710.62125217
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61126129
87Base excision repair_Homo sapiens_hsa034100.58587035
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56592257
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.55724901
90Hippo signaling pathway_Homo sapiens_hsa043900.54829865
91Basal cell carcinoma_Homo sapiens_hsa052170.50942411
92Caffeine metabolism_Homo sapiens_hsa002320.49327837
93Arachidonic acid metabolism_Homo sapiens_hsa005900.47812467
94Sulfur relay system_Homo sapiens_hsa041220.46625996
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42648053
96Folate biosynthesis_Homo sapiens_hsa007900.40834930
97mRNA surveillance pathway_Homo sapiens_hsa030150.40193554
98Lysine degradation_Homo sapiens_hsa003100.38335088
99Protein digestion and absorption_Homo sapiens_hsa049740.34943199
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34075859

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