ZNF321P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of 5.8S rRNA (GO:0000460)5.64927162
2DNA deamination (GO:0045006)5.43532438
3protein import into peroxisome matrix (GO:0016558)4.70950234
4negative regulation of protein oligomerization (GO:0032460)4.46883968
5L-fucose catabolic process (GO:0042355)4.35550205
6fucose catabolic process (GO:0019317)4.35550205
7L-fucose metabolic process (GO:0042354)4.35550205
8platelet dense granule organization (GO:0060155)4.21154073
9behavioral response to nicotine (GO:0035095)4.20157019
10protein-cofactor linkage (GO:0018065)4.14463491
11nucleotide transmembrane transport (GO:1901679)4.12779409
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.00180722
13protein complex biogenesis (GO:0070271)3.97519362
14rRNA catabolic process (GO:0016075)3.97220031
15mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.82686478
16mitochondrial respiratory chain complex I assembly (GO:0032981)3.82686478
17NADH dehydrogenase complex assembly (GO:0010257)3.82686478
18mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.82639336
19negative regulation of telomere maintenance (GO:0032205)3.76272507
20tryptophan catabolic process (GO:0006569)3.70080831
21indole-containing compound catabolic process (GO:0042436)3.70080831
22indolalkylamine catabolic process (GO:0046218)3.70080831
23mitochondrial respiratory chain complex assembly (GO:0033108)3.66098203
24indolalkylamine metabolic process (GO:0006586)3.59003999
25response to pheromone (GO:0019236)3.46269143
26water-soluble vitamin biosynthetic process (GO:0042364)3.38571538
27adaptation of signaling pathway (GO:0023058)3.35034897
28tryptophan metabolic process (GO:0006568)3.30527591
29epithelial cilium movement (GO:0003351)3.28113861
30sulfation (GO:0051923)3.22581817
31intracellular protein transmembrane import (GO:0044743)3.21384142
32kynurenine metabolic process (GO:0070189)3.20148839
33ATP synthesis coupled proton transport (GO:0015986)3.19702378
34energy coupled proton transport, down electrochemical gradient (GO:0015985)3.19702378
35protein localization to peroxisome (GO:0072662)3.19206062
36protein targeting to peroxisome (GO:0006625)3.19206062
37establishment of protein localization to peroxisome (GO:0072663)3.19206062
38nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.13747906
39respiratory chain complex IV assembly (GO:0008535)3.11188332
40exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.09819296
41piRNA metabolic process (GO:0034587)3.04125916
42preassembly of GPI anchor in ER membrane (GO:0016254)3.03630863
43mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.03329971
44cytochrome complex assembly (GO:0017004)3.01646999
45cellular ketone body metabolic process (GO:0046950)3.01388393
46negative regulation of mast cell activation (GO:0033004)2.96199684
47cilium or flagellum-dependent cell motility (GO:0001539)2.94900859
48mannosylation (GO:0097502)2.87777032
49detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.84910793
50electron transport chain (GO:0022900)2.82943000
51DNA double-strand break processing (GO:0000729)2.77610811
52RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.76626382
53respiratory electron transport chain (GO:0022904)2.75097409
54indole-containing compound metabolic process (GO:0042430)2.73559326
55transcription elongation from RNA polymerase III promoter (GO:0006385)2.72687505
56termination of RNA polymerase III transcription (GO:0006386)2.72687505
57tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.67243598
58RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.67243598
59axoneme assembly (GO:0035082)2.66834083
60peroxisomal transport (GO:0043574)2.65334489
61ketone body metabolic process (GO:1902224)2.64911890
62rhodopsin mediated signaling pathway (GO:0016056)2.64736293
63replication fork processing (GO:0031297)2.63144468
64regulation of rhodopsin mediated signaling pathway (GO:0022400)2.62962880
65positive regulation of defense response to virus by host (GO:0002230)2.61811339
66ubiquinone biosynthetic process (GO:0006744)2.61102703
67cellular biogenic amine catabolic process (GO:0042402)2.61056387
68amine catabolic process (GO:0009310)2.61056387
69recombinational repair (GO:0000725)2.59952234
70neural tube formation (GO:0001841)2.59350393
71cilium movement (GO:0003341)2.59340026
72double-strand break repair via homologous recombination (GO:0000724)2.58621687
73DNA methylation involved in gamete generation (GO:0043046)2.54180565
74regulation of cilium movement (GO:0003352)2.52911634
75tRNA processing (GO:0008033)2.49074675
76pseudouridine synthesis (GO:0001522)2.48855278
77nonmotile primary cilium assembly (GO:0035058)2.48136761
78adenosine metabolic process (GO:0046085)2.48092859
79GPI anchor metabolic process (GO:0006505)2.47475287
80regulation of protein homooligomerization (GO:0032462)2.47428232
81regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.47075320
82regulation of hexokinase activity (GO:1903299)2.46425247
83regulation of glucokinase activity (GO:0033131)2.46425247
84S-adenosylmethionine metabolic process (GO:0046500)2.46271996
85protein neddylation (GO:0045116)2.43493883
86ubiquinone metabolic process (GO:0006743)2.42269037
87regulation of nuclear cell cycle DNA replication (GO:0033262)2.41907526
88intracellular protein transmembrane transport (GO:0065002)2.39819234
89aromatic amino acid family catabolic process (GO:0009074)2.39616580
90ncRNA catabolic process (GO:0034661)2.38421878
91cAMP catabolic process (GO:0006198)2.37157042
92cytidine deamination (GO:0009972)2.36437783
93cytidine metabolic process (GO:0046087)2.36437783
94cytidine catabolic process (GO:0006216)2.36437783
95protein K11-linked deubiquitination (GO:0035871)2.35747845
96reciprocal meiotic recombination (GO:0007131)2.35641754
97reciprocal DNA recombination (GO:0035825)2.35641754
98establishment of protein localization to mitochondrial membrane (GO:0090151)2.35361680
99negative regulation of transcription regulatory region DNA binding (GO:2000678)2.35315998
100detection of light stimulus involved in sensory perception (GO:0050962)2.34675149

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.14518481
2VDR_22108803_ChIP-Seq_LS180_Human3.41539595
3MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.82792210
4GABP_17652178_ChIP-ChIP_JURKAT_Human2.76966526
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.76573333
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.43853290
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.43356446
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.28399569
9IGF1R_20145208_ChIP-Seq_DFB_Human2.27624550
10NOTCH1_21737748_ChIP-Seq_TLL_Human2.22241518
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.21213562
12GBX2_23144817_ChIP-Seq_PC3_Human2.21063056
13EWS_26573619_Chip-Seq_HEK293_Human2.18637823
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.12157695
15IRF1_19129219_ChIP-ChIP_H3396_Human2.10092937
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.07728015
17FUS_26573619_Chip-Seq_HEK293_Human2.05620343
18CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03657664
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.02488604
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.89608588
21EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.88637435
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79953561
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.78549109
24VDR_23849224_ChIP-Seq_CD4+_Human1.77874100
25P300_19829295_ChIP-Seq_ESCs_Human1.77584803
26TAF15_26573619_Chip-Seq_HEK293_Human1.77556864
27ELK1_19687146_ChIP-ChIP_HELA_Human1.73563573
28ER_23166858_ChIP-Seq_MCF-7_Human1.72390609
29MYC_18940864_ChIP-ChIP_HL60_Human1.71051782
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.68636724
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.68148730
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63250831
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.61522483
34MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.60130914
35FOXA1_25329375_ChIP-Seq_VCAP_Human1.54694599
36FOXA1_27270436_Chip-Seq_PROSTATE_Human1.54694599
37TP53_22573176_ChIP-Seq_HFKS_Human1.54159670
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.46367034
39IRF8_22096565_ChIP-ChIP_GC-B_Human1.44393356
40CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.43547949
41EZH2_22144423_ChIP-Seq_EOC_Human1.42632446
42NANOG_19829295_ChIP-Seq_ESCs_Human1.42042144
43SOX2_19829295_ChIP-Seq_ESCs_Human1.42042144
44JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.41999506
45GATA3_21878914_ChIP-Seq_MCF-7_Human1.41797334
46BCAT_22108803_ChIP-Seq_LS180_Human1.39440076
47AR_20517297_ChIP-Seq_VCAP_Human1.38109532
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37994411
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35635513
50CBP_20019798_ChIP-Seq_JUKART_Human1.35635513
51FOXP3_21729870_ChIP-Seq_TREG_Human1.35307478
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35111900
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.33622808
54GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29736879
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29501743
56ETV2_25802403_ChIP-Seq_MESCs_Mouse1.29060241
57EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.28352012
58AR_25329375_ChIP-Seq_VCAP_Human1.26371073
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25311497
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24471735
61NCOR_22424771_ChIP-Seq_293T_Human1.20555357
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19175722
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.19086676
64FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18677646
65STAT3_23295773_ChIP-Seq_U87_Human1.15813676
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14706828
67AUTS2_25519132_ChIP-Seq_293T-REX_Human1.14089236
68TCF4_23295773_ChIP-Seq_U87_Human1.13398166
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12599930
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.12535931
71CBX2_27304074_Chip-Seq_ESCs_Mouse1.12149596
72TCF4_22108803_ChIP-Seq_LS180_Human1.10679181
73EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10550690
74ELF1_17652178_ChIP-ChIP_JURKAT_Human1.10186762
75RNF2_27304074_Chip-Seq_NSC_Mouse1.07591754
76POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07126898
77NANOG_20526341_ChIP-Seq_ESCs_Human1.06818634
78LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06569418
79CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06313517
80TP63_19390658_ChIP-ChIP_HaCaT_Human1.05229822
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03406006
82CRX_20693478_ChIP-Seq_RETINA_Mouse1.02883561
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.02849688
84KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02616098
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02182452
86SMAD4_21799915_ChIP-Seq_A2780_Human1.02166853
87HOXB7_26014856_ChIP-Seq_BT474_Human1.01874849
88PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01745575
89TAF2_19829295_ChIP-Seq_ESCs_Human1.01256106
90RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00734458
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00626991
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99045360
93TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98697658
94SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97302117
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96786711
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96786711
97RUNX2_22187159_ChIP-Seq_PCA_Human0.95777516
98REST_21632747_ChIP-Seq_MESCs_Mouse0.95700536
99MYC_19829295_ChIP-Seq_ESCs_Human0.94602922
100PRDM14_20953172_ChIP-Seq_ESCs_Human0.94589552

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat3.56422980
2MP0006082_CNS_inflammation2.82036131
3MP0006292_abnormal_olfactory_placode2.79885872
4MP0008877_abnormal_DNA_methylation2.70531816
5MP0002837_dystrophic_cardiac_calcinosis2.68778128
6MP0003195_calcinosis2.54239531
7MP0002876_abnormal_thyroid_physiology2.37886585
8MP0006072_abnormal_retinal_apoptosis2.27507634
9MP0001873_stomach_inflammation2.08143205
10MP0005551_abnormal_eye_electrophysiolog2.07377399
11MP0000372_irregular_coat_pigmentation2.00499566
12MP0001968_abnormal_touch/_nociception1.99540296
13MP0002102_abnormal_ear_morphology1.98898878
14MP0005084_abnormal_gallbladder_morpholo1.97733064
15MP0001986_abnormal_taste_sensitivity1.87940099
16MP0009046_muscle_twitch1.76451030
17MP0003787_abnormal_imprinting1.75034064
18MP0002638_abnormal_pupillary_reflex1.70681488
19MP0000631_abnormal_neuroendocrine_gland1.66268152
20MP0002163_abnormal_gland_morphology1.65243640
21MP0008872_abnormal_physiological_respon1.64397287
22MP0005645_abnormal_hypothalamus_physiol1.62324166
23MP0002736_abnormal_nociception_after1.60855632
24MP0005253_abnormal_eye_physiology1.60756582
25MP0008875_abnormal_xenobiotic_pharmacok1.60168638
26MP0004142_abnormal_muscle_tone1.60037981
27MP0000569_abnormal_digit_pigmentation1.54998464
28MP0008995_early_reproductive_senescence1.54219403
29MP0005671_abnormal_response_to1.53451522
30MP0003011_delayed_dark_adaptation1.51375838
31MP0005646_abnormal_pituitary_gland1.47277239
32MP0005379_endocrine/exocrine_gland_phen1.44979544
33MP0004147_increased_porphyrin_level1.44952556
34MP0002938_white_spotting1.43876834
35MP0005389_reproductive_system_phenotype1.43818702
36MP0003136_yellow_coat_color1.43531647
37MP0002277_abnormal_respiratory_mucosa1.43032243
38MP0004885_abnormal_endolymph1.42987172
39MP0002132_abnormal_respiratory_system1.42514089
40MP0005174_abnormal_tail_pigmentation1.40180661
41MP0004043_abnormal_pH_regulation1.37304407
42MP0008058_abnormal_DNA_repair1.36682067
43MP0009745_abnormal_behavioral_response1.36375558
44MP0003718_maternal_effect1.34289655
45MP0005075_abnormal_melanosome_morpholog1.33844561
46MP0001919_abnormal_reproductive_system1.32828215
47MP0001501_abnormal_sleep_pattern1.30789994
48MP0002272_abnormal_nervous_system1.30692336
49MP0009379_abnormal_foot_pigmentation1.27429310
50MP0000427_abnormal_hair_cycle1.26410776
51MP0004133_heterotaxia1.26306493
52MP0003646_muscle_fatigue1.22585599
53MP0006276_abnormal_autonomic_nervous1.13599366
54MP0002160_abnormal_reproductive_system1.12258068
55MP0003880_abnormal_central_pattern1.10518439
56MP0002653_abnormal_ependyma_morphology1.09755260
57MP0001984_abnormal_olfaction1.09065679
58MP0001764_abnormal_homeostasis1.08404172
59MP0002095_abnormal_skin_pigmentation1.07355421
60MP0002138_abnormal_hepatobiliary_system1.05315511
61MP0002693_abnormal_pancreas_physiology1.04538015
62MP0002928_abnormal_bile_duct1.04328156
63MP0002735_abnormal_chemical_nociception1.00641290
64MP0003786_premature_aging0.99015277
65MP0005410_abnormal_fertilization0.97943763
66MP0001485_abnormal_pinna_reflex0.97895490
67MP0002557_abnormal_social/conspecific_i0.92013899
68MP0001293_anophthalmia0.89042275
69MP0005195_abnormal_posterior_eye0.88627110
70MP0000230_abnormal_systemic_arterial0.87919803
71MP0002733_abnormal_thermal_nociception0.87251541
72MP0010386_abnormal_urinary_bladder0.86913887
73MP0001905_abnormal_dopamine_level0.86371733
74MP0001970_abnormal_pain_threshold0.85700594
75MP0005310_abnormal_salivary_gland0.84475888
76MP0000383_abnormal_hair_follicle0.84249670
77MP0002234_abnormal_pharynx_morphology0.83693441
78MP0001346_abnormal_lacrimal_gland0.81784852
79MP0001486_abnormal_startle_reflex0.81660363
80MP0003698_abnormal_male_reproductive0.81431521
81MP0003252_abnormal_bile_duct0.80895457
82MP0002067_abnormal_sensory_capabilities0.77229802
83MP0006036_abnormal_mitochondrial_physio0.76352282
84MP0002572_abnormal_emotion/affect_behav0.75345946
85MP0001119_abnormal_female_reproductive0.75058913
86MP0000653_abnormal_sex_gland0.73565142
87MP0001929_abnormal_gametogenesis0.73099880
88MP0003724_increased_susceptibility_to0.72760922
89MP0004145_abnormal_muscle_electrophysio0.71587963
90MP0005636_abnormal_mineral_homeostasis0.71565679
91MP0003186_abnormal_redox_activity0.71473874
92MP0001944_abnormal_pancreas_morphology0.71372546
93MP0002210_abnormal_sex_determination0.71229575
94MP0002751_abnormal_autonomic_nervous0.70648163
95MP0003693_abnormal_embryo_hatching0.70487687
96MP0002752_abnormal_somatic_nervous0.70433081
97MP0004742_abnormal_vestibular_system0.69810646
98MP0002229_neurodegeneration0.69733862
99MP0005167_abnormal_blood-brain_barrier0.69181534
100MP0002064_seizures0.67735698

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.97931278
2Pancreatic fibrosis (HP:0100732)3.73263009
3Molar tooth sign on MRI (HP:0002419)3.65654460
4Abnormality of midbrain morphology (HP:0002418)3.65654460
5Congenital stationary night blindness (HP:0007642)3.55519323
6True hermaphroditism (HP:0010459)3.50792887
7Type II lissencephaly (HP:0007260)3.38466145
8Nephronophthisis (HP:0000090)3.24878702
9Stomach cancer (HP:0012126)3.16385467
10Brushfield spots (HP:0001088)2.94168907
11Polydipsia (HP:0001959)2.85636279
12Abnormal drinking behavior (HP:0030082)2.85636279
13Methylmalonic acidemia (HP:0002912)2.83473277
14Mitochondrial inheritance (HP:0001427)2.80910953
15Medial flaring of the eyebrow (HP:0010747)2.76320122
163-Methylglutaconic aciduria (HP:0003535)2.74821734
17Aplasia/Hypoplasia of the spleen (HP:0010451)2.74627420
18Abnormality of the renal medulla (HP:0100957)2.74226471
19Acute necrotizing encephalopathy (HP:0006965)2.71419232
20Abnormality of the renal cortex (HP:0011035)2.71132326
21Increased CSF lactate (HP:0002490)2.69045678
22Asplenia (HP:0001746)2.66586909
23Methylmalonic aciduria (HP:0012120)2.65012940
24Pendular nystagmus (HP:0012043)2.62066491
25Congenital, generalized hypertrichosis (HP:0004540)2.60266632
26Abnormal rod and cone electroretinograms (HP:0008323)2.55620799
27Attenuation of retinal blood vessels (HP:0007843)2.54730661
28Cerebellar dysplasia (HP:0007033)2.54713894
29Dynein arm defect of respiratory motile cilia (HP:0012255)2.48644388
30Absent/shortened dynein arms (HP:0200106)2.48644388
31Abnormality of alanine metabolism (HP:0010916)2.46621447
32Hyperalaninemia (HP:0003348)2.46621447
33Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.46621447
34Decreased central vision (HP:0007663)2.46132398
35Abolished electroretinogram (ERG) (HP:0000550)2.45141191
36Hepatocellular necrosis (HP:0001404)2.44915493
37Abnormal mitochondria in muscle tissue (HP:0008316)2.37069564
38Acute encephalopathy (HP:0006846)2.33283979
39Abnormality of B cell number (HP:0010975)2.32772492
40Hepatic necrosis (HP:0002605)2.31176762
41Stomatitis (HP:0010280)2.30681330
42Progressive macrocephaly (HP:0004481)2.29353232
43Chronic hepatic failure (HP:0100626)2.29276368
44Cystic liver disease (HP:0006706)2.29180146
45Absent rod-and cone-mediated responses on ERG (HP:0007688)2.26368448
46Tubular atrophy (HP:0000092)2.23866555
47Hyperventilation (HP:0002883)2.22797747
48Decreased electroretinogram (ERG) amplitude (HP:0000654)2.21778688
49Polyuria (HP:0000103)2.21393419
50Aplasia/Hypoplasia of the tibia (HP:0005772)2.18400217
51Abnormal respiratory epithelium morphology (HP:0012253)2.16569200
52Abnormal respiratory motile cilium morphology (HP:0005938)2.16569200
53Abnormality of the pons (HP:0007361)2.12876915
54Bile duct proliferation (HP:0001408)2.12418768
55Abnormal biliary tract physiology (HP:0012439)2.12418768
56Hypoplasia of the pons (HP:0012110)2.09298885
57Lipid accumulation in hepatocytes (HP:0006561)2.09290154
58Furrowed tongue (HP:0000221)2.08883814
59Renal cortical cysts (HP:0000803)2.07006276
60Abnormal number of erythroid precursors (HP:0012131)2.03410849
61Congenital primary aphakia (HP:0007707)2.01704524
62Gait imbalance (HP:0002141)2.01094288
63Optic disc pallor (HP:0000543)2.00278565
64Increased hepatocellular lipid droplets (HP:0006565)1.99427588
65Concave nail (HP:0001598)1.98926886
66Increased corneal curvature (HP:0100692)1.98458807
67Keratoconus (HP:0000563)1.98458807
68Sclerocornea (HP:0000647)1.96179635
69Anencephaly (HP:0002323)1.94078070
70Hypomagnesemia (HP:0002917)1.93952308
71Abnormal ciliary motility (HP:0012262)1.93119573
72Increased serum lactate (HP:0002151)1.92994723
73Gaze-evoked nystagmus (HP:0000640)1.90985472
74Severe muscular hypotonia (HP:0006829)1.87915117
75Short tibia (HP:0005736)1.87772045
76Recurrent cutaneous fungal infections (HP:0011370)1.86212252
77Chronic mucocutaneous candidiasis (HP:0002728)1.86212252
78Male pseudohermaphroditism (HP:0000037)1.85633931
79Optic nerve hypoplasia (HP:0000609)1.83578429
80Lactic acidosis (HP:0003128)1.83000948
81Nephrogenic diabetes insipidus (HP:0009806)1.82860249
82Congenital hepatic fibrosis (HP:0002612)1.81964031
83Ketoacidosis (HP:0001993)1.81641201
84Ketosis (HP:0001946)1.80813258
85Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.80754317
86Large for gestational age (HP:0001520)1.80489582
87Abnormality of homocysteine metabolism (HP:0010919)1.80219073
88Homocystinuria (HP:0002156)1.80219073
89Lissencephaly (HP:0001339)1.79815462
90Aplasia/hypoplasia of the uterus (HP:0008684)1.77541653
91Aplasia/Hypoplasia of the tongue (HP:0010295)1.77012962
92Abnormality of vitamin B metabolism (HP:0004340)1.76586741
93Inability to walk (HP:0002540)1.76434814
94Aplastic anemia (HP:0001915)1.76136096
95Abnormality of cells of the erythroid lineage (HP:0012130)1.75530308
96Flat occiput (HP:0005469)1.74665676
97Colon cancer (HP:0003003)1.74514670
98Abnormal urine output (HP:0012590)1.73829562
99Female pseudohermaphroditism (HP:0010458)1.73800766
100Abnormal delayed hypersensitivity skin test (HP:0002963)1.70732282

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.50200272
2ADRBK23.18196209
3PASK3.06487769
4ZAK2.90350151
5MAP4K22.82542021
6BMPR1B2.68397553
7GRK12.58032387
8PINK12.54690231
9TAOK32.44158862
10NUAK12.37578849
11WNK32.19602801
12TLK12.12685178
13TIE11.91077375
14TXK1.85415781
15ACVR1B1.85028434
16INSRR1.72734373
17ITK1.66127304
18WNK41.65378680
19VRK21.60165356
20BCKDK1.52933402
21TEC1.42411833
22MAPK131.39163709
23STK161.36118377
24CASK1.30190095
25MAP3K131.26638355
26OXSR11.24215550
27MKNK21.24128406
28TNIK1.23032536
29IKBKB1.20240577
30VRK11.18942659
31DAPK21.14566127
32BRSK21.13750917
33MST41.08524057
34MAP3K41.06572806
35TRIM281.02737429
36KIT0.99328132
37DYRK20.99178057
38ADRBK10.98732496
39NME10.96674276
40MKNK10.92957601
41CSNK1G10.90657863
42CSNK1G30.87383822
43PRKCQ0.82432450
44CSNK1G20.81936145
45CAMKK10.80251169
46MAP2K70.76267681
47MAPK150.75667158
48TGFBR10.74248589
49STK390.73737150
50FLT30.73628647
51EIF2AK30.71685277
52CSNK1A1L0.70052790
53CAMKK20.69897383
54PRKCE0.69567609
55MUSK0.66729064
56STK38L0.66422910
57PRKCG0.65723791
58PKN10.65515796
59FGFR20.65100531
60PAK30.65013065
61MAPKAPK30.63442798
62PLK40.62588547
63MAP3K120.61747770
64PIK3CA0.61339198
65TNK20.61151384
66RPS6KA50.57949932
67PHKG10.57648400
68PHKG20.57648400
69BTK0.57289333
70NLK0.56598939
71PLK30.55193927
72BCR0.55135467
73CHUK0.54770327
74MAP3K140.54166664
75ERBB30.53854615
76MAP2K60.52727078
77SYK0.52634981
78CSNK1A10.51566050
79CDC70.47219524
80MAPKAPK50.47176632
81LYN0.45097633
82CHEK20.44988332
83PRKACA0.44559122
84PLK10.44347950
85IKBKE0.44302752
86GRK70.42640979
87LCK0.42023611
88IRAK10.41304560
89STK30.40732476
90ATR0.40674450
91KDR0.40305687
92PLK20.39917352
93MATK0.38377450
94TAF10.37699094
95PTK2B0.35796644
96IGF1R0.35453853
97MAP3K70.35340281
98PRKCA0.34573186
99DYRK30.33817059
100EIF2AK20.33348178

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.27602104
2Parkinsons disease_Homo sapiens_hsa050122.53645037
3Phototransduction_Homo sapiens_hsa047442.43231726
4RNA polymerase_Homo sapiens_hsa030202.38320593
5Ribosome_Homo sapiens_hsa030102.30289992
6Protein export_Homo sapiens_hsa030602.20337365
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.12034426
8Homologous recombination_Homo sapiens_hsa034402.10907506
9Linoleic acid metabolism_Homo sapiens_hsa005912.03152137
10Fanconi anemia pathway_Homo sapiens_hsa034602.00255998
11Nitrogen metabolism_Homo sapiens_hsa009101.99642563
12Maturity onset diabetes of the young_Homo sapiens_hsa049501.97518816
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88944546
14Butanoate metabolism_Homo sapiens_hsa006501.82438694
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.80968292
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.79708413
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.76056926
18Huntingtons disease_Homo sapiens_hsa050161.71956117
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.71457354
20Proteasome_Homo sapiens_hsa030501.70526618
21Caffeine metabolism_Homo sapiens_hsa002321.68450601
22RNA degradation_Homo sapiens_hsa030181.67951535
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.67575718
24Primary immunodeficiency_Homo sapiens_hsa053401.65545522
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.65267657
26Alzheimers disease_Homo sapiens_hsa050101.64698592
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.63370666
28Peroxisome_Homo sapiens_hsa041461.54568032
29Basal transcription factors_Homo sapiens_hsa030221.52422922
30One carbon pool by folate_Homo sapiens_hsa006701.51978459
31Asthma_Homo sapiens_hsa053101.49443392
32Tryptophan metabolism_Homo sapiens_hsa003801.48827504
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.48811154
34Graft-versus-host disease_Homo sapiens_hsa053321.48792863
35Selenocompound metabolism_Homo sapiens_hsa004501.48466174
36Autoimmune thyroid disease_Homo sapiens_hsa053201.42651562
37Allograft rejection_Homo sapiens_hsa053301.42198462
38Cardiac muscle contraction_Homo sapiens_hsa042601.42026379
39Type I diabetes mellitus_Homo sapiens_hsa049401.40320305
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.26122427
41Regulation of autophagy_Homo sapiens_hsa041401.20888538
42Ether lipid metabolism_Homo sapiens_hsa005651.19557854
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16968555
44Olfactory transduction_Homo sapiens_hsa047401.10430717
45Propanoate metabolism_Homo sapiens_hsa006401.09974307
46Arachidonic acid metabolism_Homo sapiens_hsa005901.07860521
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07203353
48Nicotine addiction_Homo sapiens_hsa050331.05889532
49Chemical carcinogenesis_Homo sapiens_hsa052041.04545002
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.02759078
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01697284
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01104549
53Steroid hormone biosynthesis_Homo sapiens_hsa001401.00342279
54Purine metabolism_Homo sapiens_hsa002300.99473144
55Collecting duct acid secretion_Homo sapiens_hsa049660.97088489
56Retinol metabolism_Homo sapiens_hsa008300.92806442
57Pyrimidine metabolism_Homo sapiens_hsa002400.87813925
58Vitamin digestion and absorption_Homo sapiens_hsa049770.84841750
59Taste transduction_Homo sapiens_hsa047420.84198373
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.84183561
61Rheumatoid arthritis_Homo sapiens_hsa053230.83651800
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83247398
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82588612
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81449108
65ABC transporters_Homo sapiens_hsa020100.76664349
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71844091
67Morphine addiction_Homo sapiens_hsa050320.69644060
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.69161205
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66101869
70Nucleotide excision repair_Homo sapiens_hsa034200.64757522
71Metabolic pathways_Homo sapiens_hsa011000.64329509
72RNA transport_Homo sapiens_hsa030130.63294624
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59983229
74Non-homologous end-joining_Homo sapiens_hsa034500.59726606
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57966162
76Sulfur metabolism_Homo sapiens_hsa009200.56466312
77Mineral absorption_Homo sapiens_hsa049780.56213992
78Mismatch repair_Homo sapiens_hsa034300.55942246
79Insulin secretion_Homo sapiens_hsa049110.54302566
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52203962
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51127830
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50484679
83Ovarian steroidogenesis_Homo sapiens_hsa049130.50105139
84Serotonergic synapse_Homo sapiens_hsa047260.48929442
85Antigen processing and presentation_Homo sapiens_hsa046120.48745187
86Glycerolipid metabolism_Homo sapiens_hsa005610.45366122
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44791613
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42991882
89Circadian rhythm_Homo sapiens_hsa047100.41859058
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41588706
91Sulfur relay system_Homo sapiens_hsa041220.40425069
92Salivary secretion_Homo sapiens_hsa049700.40128827
93Spliceosome_Homo sapiens_hsa030400.38401948
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.35754843
95Circadian entrainment_Homo sapiens_hsa047130.35743853
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35085005
97Fat digestion and absorption_Homo sapiens_hsa049750.34881714
98Base excision repair_Homo sapiens_hsa034100.32869476
99Hematopoietic cell lineage_Homo sapiens_hsa046400.32535037
100Systemic lupus erythematosus_Homo sapiens_hsa053220.31808211

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