ZNF296

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of retinoic acid receptor signaling pathway (GO:0048387)9.95162371
2regulation of retinoic acid receptor signaling pathway (GO:0048385)8.16689038
3ribosomal small subunit biogenesis (GO:0042274)4.41543977
4immunoglobulin mediated immune response (GO:0016064)4.20274346
5deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.03506257
6maturation of SSU-rRNA (GO:0030490)3.80844134
7viral transcription (GO:0019083)3.75717929
8translational termination (GO:0006415)3.45949963
9B cell mediated immunity (GO:0019724)3.45551194
10negative regulation of B cell apoptotic process (GO:0002903)3.30973901
11positive regulation of protein homooligomerization (GO:0032464)3.29239120
12pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.27388829
13translational elongation (GO:0006414)3.24406075
14chaperone mediated protein folding requiring cofactor (GO:0051085)3.20616420
15antigen processing and presentation of endogenous antigen (GO:0019883)3.18435333
16modulation by symbiont of host defense response (GO:0052031)3.14155714
17modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.14155714
18modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.14155714
19positive regulation by organism of defense response of other organism involved in symbiotic interact3.14155714
20modulation by symbiont of host immune response (GO:0052553)3.14155714
21positive regulation by symbiont of host defense response (GO:0052509)3.14155714
22peptidyl-arginine omega-N-methylation (GO:0035247)3.02326743
23nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.00971013
24B cell receptor signaling pathway (GO:0050853)2.98606934
25transcription from mitochondrial promoter (GO:0006390)2.94572429
26histone arginine methylation (GO:0034969)2.94571704
27regulation of interferon-beta biosynthetic process (GO:0045357)2.92497633
28GDP-mannose metabolic process (GO:0019673)2.91054729
29pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.88637634
30viral life cycle (GO:0019058)2.88622274
31NIK/NF-kappaB signaling (GO:0038061)2.88328002
32detection of bacterium (GO:0016045)2.88113302
33positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.83134386
34ribosomal small subunit assembly (GO:0000028)2.81756673
35deoxyribonucleotide catabolic process (GO:0009264)2.81629423
36SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.79943598
37positive thymic T cell selection (GO:0045059)2.78642121
38response to peptidoglycan (GO:0032494)2.77650159
39DNA replication initiation (GO:0006270)2.77523814
40purine deoxyribonucleotide catabolic process (GO:0009155)2.77510908
41deoxyribose phosphate catabolic process (GO:0046386)2.76634591
42mitotic chromosome condensation (GO:0007076)2.76567072
43DNA strand elongation (GO:0022616)2.72088568
44negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.72041541
45pentose metabolic process (GO:0019321)2.71841760
46ncRNA 3-end processing (GO:0043628)2.71700108
47protein targeting to ER (GO:0045047)2.71198678
48DNA strand elongation involved in DNA replication (GO:0006271)2.69654297
49ribonucleoprotein complex biogenesis (GO:0022613)2.68977090
50cotranslational protein targeting to membrane (GO:0006613)2.68564423
51pseudouridine synthesis (GO:0001522)2.68345164
52regulation of B cell apoptotic process (GO:0002902)2.65582309
53translational initiation (GO:0006413)2.62594128
54pyrimidine nucleotide catabolic process (GO:0006244)2.61885346
55rRNA processing (GO:0006364)2.61757715
56detection of other organism (GO:0098543)2.61187887
57cellular protein complex disassembly (GO:0043624)2.59357300
58protein localization to endoplasmic reticulum (GO:0070972)2.56995455
59DNA replication checkpoint (GO:0000076)2.53867535
60establishment of protein localization to endoplasmic reticulum (GO:0072599)2.53393521
61antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.53068284
62formation of translation preinitiation complex (GO:0001731)2.52751426
63regulation of B cell receptor signaling pathway (GO:0050855)2.52055006
64telomere maintenance via semi-conservative replication (GO:0032201)2.51043654
65rRNA modification (GO:0000154)2.50409845
66negative regulation of myeloid cell apoptotic process (GO:0033033)2.50286161
67antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.49855595
68rRNA metabolic process (GO:0016072)2.48742619
69ribosome biogenesis (GO:0042254)2.48717346
70pyrimidine nucleoside salvage (GO:0043097)2.48489914
71pyrimidine-containing compound salvage (GO:0008655)2.48489914
72protein localization to chromosome, centromeric region (GO:0071459)2.47954240
73positive regulation of gamma-delta T cell activation (GO:0046645)2.46023977
74negative regulation of cell killing (GO:0031342)2.45780854
75negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.45780854
76B cell homeostasis (GO:0001782)2.45721805
77peptidyl-arginine N-methylation (GO:0035246)2.44716447
78peptidyl-arginine methylation (GO:0018216)2.44716447
79CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.44221126
80chaperone-mediated protein transport (GO:0072321)2.44175927
81positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.42344692
82positive regulation of protein oligomerization (GO:0032461)2.41517663
83regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.40788919
84negative regulation of DNA-templated transcription, elongation (GO:0032785)2.40513690
85base-excision repair, AP site formation (GO:0006285)2.39974322
86positive regulation of prostaglandin secretion (GO:0032308)2.39634070
87positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.39435960
88positive regulation of interferon-alpha production (GO:0032727)2.38386314
89protein targeting to mitochondrion (GO:0006626)2.38161907
90regulation of superoxide anion generation (GO:0032928)2.38011892
91rRNA transcription (GO:0009303)2.37811390
92antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.35490249
93defense response to protozoan (GO:0042832)2.35187167
94response to protozoan (GO:0001562)2.34876552
95myeloid dendritic cell activation (GO:0001773)2.34378687
96regulation of mitochondrial translation (GO:0070129)2.33407122
97cellular response to virus (GO:0098586)2.32949490
98regulation of protein heterodimerization activity (GO:0043497)2.32901198
99termination of RNA polymerase III transcription (GO:0006386)2.32730306
100transcription elongation from RNA polymerase III promoter (GO:0006385)2.32730306

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.25355249
2E2F7_22180533_ChIP-Seq_HELA_Human3.12613645
3MYC_22102868_ChIP-Seq_BL_Human2.97260597
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.93216633
5VDR_21846776_ChIP-Seq_THP-1_Human2.89845515
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.73714173
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.51900316
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.36346163
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.32550732
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.29986710
11TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19958143
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.13802220
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.02993665
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.00845801
15XRN2_22483619_ChIP-Seq_HELA_Human1.97808298
16ELF1_17652178_ChIP-ChIP_JURKAT_Human1.95562360
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.94629619
18IRF8_22096565_ChIP-ChIP_GC-B_Human1.93855235
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.92803516
20MYC_19079543_ChIP-ChIP_MESCs_Mouse1.89129178
21MYC_19030024_ChIP-ChIP_MESCs_Mouse1.86661837
22TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.83842067
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.83286393
24CIITA_25753668_ChIP-Seq_RAJI_Human1.82352662
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.78973452
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.76168483
27THAP11_20581084_ChIP-Seq_MESCs_Mouse1.75755566
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.74748788
29LXR_22292898_ChIP-Seq_THP-1_Human1.67994128
30YY1_21170310_ChIP-Seq_MESCs_Mouse1.64239868
31* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.62843413
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.61307475
33ZNF263_19887448_ChIP-Seq_K562_Human1.60186464
34CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.59150662
35VDR_24763502_ChIP-Seq_THP-1_Human1.58001676
36* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.56395353
37* GABP_19822575_ChIP-Seq_HepG2_Human1.54978134
38MAF_26560356_Chip-Seq_TH1_Human1.52184841
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.48668571
40TET1_21451524_ChIP-Seq_MESCs_Mouse1.46787888
41DCP1A_22483619_ChIP-Seq_HELA_Human1.46612613
42CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.45959006
43FOXP3_21729870_ChIP-Seq_TREG_Human1.45934007
44UTX_26944678_Chip-Seq_JUKART_Human1.45796522
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.44247571
46SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.44002878
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.43784319
48FOXM1_23109430_ChIP-Seq_U2OS_Human1.43499166
49GABP_17652178_ChIP-ChIP_JURKAT_Human1.42618018
50MAF_26560356_Chip-Seq_TH2_Human1.41807148
51VDR_23849224_ChIP-Seq_CD4+_Human1.41383706
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.40117346
53P68_20966046_ChIP-Seq_HELA_Human1.39719776
54SPI1_23547873_ChIP-Seq_NB4_Human1.38437765
55ELK3_25401928_ChIP-Seq_HUVEC_Human1.37882386
56STAT4_19710469_ChIP-ChIP_TH1__Mouse1.34217783
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33527525
58BCOR_27268052_Chip-Seq_Bcells_Human1.32919817
59E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32308356
60MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.30831539
61BCL6_27268052_Chip-Seq_Bcells_Human1.30699898
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.30659784
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.28171701
64ELF1_20517297_ChIP-Seq_JURKAT_Human1.27118809
65IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26180804
66TTF2_22483619_ChIP-Seq_HELA_Human1.24664273
67RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.24265127
68E2F4_17652178_ChIP-ChIP_JURKAT_Human1.24218349
69BP1_19119308_ChIP-ChIP_Hs578T_Human1.22214159
70PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21915495
71NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21735704
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21297254
73RUNX1_22412390_ChIP-Seq_EML_Mouse1.21120793
74SRY_22984422_ChIP-ChIP_TESTIS_Rat1.20775514
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19623291
76KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19034550
77TCF7_22412390_ChIP-Seq_EML_Mouse1.18803955
78CTCF_26484167_Chip-Seq_Bcells_Mouse1.18295697
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17613145
80KDM5A_27292631_Chip-Seq_BREAST_Human1.16734731
81RACK7_27058665_Chip-Seq_MCF-7_Human1.14665374
82SA1_27219007_Chip-Seq_ERYTHROID_Human1.13908126
83IRF8_21731497_ChIP-ChIP_J774_Mouse1.13522834
84ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12597787
85BRD4_27068464_Chip-Seq_AML-cells_Mouse1.12257832
86EGR1_19374776_ChIP-ChIP_THP-1_Human1.11122604
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10817480
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10576774
89CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10044156
90KDM2B_26808549_Chip-Seq_DND41_Human1.08862184
91TFEB_21752829_ChIP-Seq_HELA_Human1.08570468
92KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07994049
93PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07798056
94CTCF_21964334_Chip-Seq_Bcells_Human1.07156403
95ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06813074
96E2F1_20622854_ChIP-Seq_HELA_Human1.06494120
97PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.06139511
98SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05567275
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04758180
100GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03408387

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.38142199
2MP0003693_abnormal_embryo_hatching3.16028590
3MP0000685_abnormal_immune_system3.04427239
4MP0009333_abnormal_splenocyte_physiolog2.80034337
5MP0001800_abnormal_humoral_immune2.70523387
6MP0005671_abnormal_response_to2.63938208
7MP0005387_immune_system_phenotype2.59624577
8MP0001790_abnormal_immune_system2.59624577
9MP0003763_abnormal_thymus_physiology2.53630353
10MP0005000_abnormal_immune_tolerance2.36020922
11MP0002452_abnormal_antigen_presenting2.35507886
12MP0003436_decreased_susceptibility_to2.35487840
13MP0010094_abnormal_chromosome_stability2.32032490
14MP0002723_abnormal_immune_serum2.30705205
15MP0002420_abnormal_adaptive_immunity2.24833069
16MP0001819_abnormal_immune_cell2.22962501
17MP0005451_abnormal_body_composition2.22897701
18MP0003303_peritoneal_inflammation2.19638993
19MP0002398_abnormal_bone_marrow2.19603901
20MP0008260_abnormal_autophagy2.17502126
21MP0004957_abnormal_blastocyst_morpholog2.15837421
22MP0005025_abnormal_response_to2.15512212
23MP0003111_abnormal_nucleus_morphology2.14639735
24MP0002148_abnormal_hypersensitivity_rea2.01684511
25MP0003077_abnormal_cell_cycle1.93046756
26MP0000716_abnormal_immune_system1.92467523
27MP0002163_abnormal_gland_morphology1.91392619
28MP0002419_abnormal_innate_immunity1.91375024
29MP0008058_abnormal_DNA_repair1.90282512
30MP0002132_abnormal_respiratory_system1.83996853
31MP0002138_abnormal_hepatobiliary_system1.83489576
32MP0000689_abnormal_spleen_morphology1.78171441
33MP0002722_abnormal_immune_system1.78165554
34MP0001873_stomach_inflammation1.77869697
35MP0002396_abnormal_hematopoietic_system1.76397329
36MP0002429_abnormal_blood_cell1.75773843
37MP0000703_abnormal_thymus_morphology1.73723485
38MP0009785_altered_susceptibility_to1.72559930
39MP0001986_abnormal_taste_sensitivity1.70388664
40MP0000678_abnormal_parathyroid_gland1.64576582
41MP0005058_abnormal_lysosome_morphology1.59306751
42MP0003786_premature_aging1.51400497
43MP0009278_abnormal_bone_marrow1.50905117
44MP0000490_abnormal_crypts_of1.49484928
45MP0005310_abnormal_salivary_gland1.48904167
46MP0003806_abnormal_nucleotide_metabolis1.46519725
47MP0006035_abnormal_mitochondrial_morpho1.44205217
48MP0002254_reproductive_system_inflammat1.40853923
49MP0004510_myositis1.39239447
50MP0001853_heart_inflammation1.36586296
51MP0000313_abnormal_cell_death1.35507790
52MP0006036_abnormal_mitochondrial_physio1.34185206
53MP0005464_abnormal_platelet_physiology1.31972257
54MP0000350_abnormal_cell_proliferation1.31730211
55MP0000858_altered_metastatic_potential1.31564957
56MP0008932_abnormal_embryonic_tissue1.26698849
57MP0002405_respiratory_system_inflammati1.26020242
58MP0001845_abnormal_inflammatory_respons1.23371424
59MP0003183_abnormal_peptide_metabolism1.23045018
60MP0002019_abnormal_tumor_incidence1.22972547
61MP0010155_abnormal_intestine_physiology1.19926938
62MP0008057_abnormal_DNA_replication1.17588829
63MP0004947_skin_inflammation1.16002180
64MP0003866_abnormal_defecation1.12015134
65MP0008469_abnormal_protein_level1.10060290
66MP0002277_abnormal_respiratory_mucosa1.09936918
67MP0001730_embryonic_growth_arrest1.06237584
68MP0004381_abnormal_hair_follicle1.05966842
69MP0003718_maternal_effect1.05439242
70MP0005501_abnormal_skin_physiology1.05340798
71MP0001545_abnormal_hematopoietic_system1.04866324
72MP0005397_hematopoietic_system_phenotyp1.04866324
73MP0002796_impaired_skin_barrier1.01382556
74MP0000372_irregular_coat_pigmentation0.96037818
75MP0005645_abnormal_hypothalamus_physiol0.95700675
76MP0004808_abnormal_hematopoietic_stem0.88241531
77MP0006082_CNS_inflammation0.83290551
78MP0005075_abnormal_melanosome_morpholog0.82711718
79MP0001881_abnormal_mammary_gland0.82483890
80MP0001764_abnormal_homeostasis0.80892955
81MP0000015_abnormal_ear_pigmentation0.79824811
82MP0005084_abnormal_gallbladder_morpholo0.77632555
83MP0008007_abnormal_cellular_replicative0.75918186
84MP0000358_abnormal_cell_content/0.75095067
85MP0000465_gastrointestinal_hemorrhage0.73221933
86MP0005076_abnormal_cell_differentiation0.71494700
87MP0002080_prenatal_lethality0.71185037
88MP0005379_endocrine/exocrine_gland_phen0.70652377
89MP0002210_abnormal_sex_determination0.69937046
90MP0010307_abnormal_tumor_latency0.69457573
91MP0002234_abnormal_pharynx_morphology0.69155723
92MP0001919_abnormal_reproductive_system0.68471152
93MP0009840_abnormal_foam_cell0.67952248
94MP0005380_embryogenesis_phenotype0.66934263
95MP0001672_abnormal_embryogenesis/_devel0.66934263
96MP0004858_abnormal_nervous_system0.66634219
97MP0003075_altered_response_to0.66236076
98MP0003453_abnormal_keratinocyte_physiol0.64724825
99MP0003724_increased_susceptibility_to0.64355649
100MP0009379_abnormal_foot_pigmentation0.62587567

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)4.61967709
2Recurrent bacterial skin infections (HP:0005406)4.51955265
3Gastrointestinal stroma tumor (HP:0100723)4.23285734
4Recurrent abscess formation (HP:0002722)4.13056541
5Meningitis (HP:0001287)3.50521123
6Obstructive lung disease (HP:0006536)3.50140315
7Chronic obstructive pulmonary disease (HP:0006510)3.50140315
8Abnormality of T cell physiology (HP:0011840)3.47450175
9Mediastinal lymphadenopathy (HP:0100721)3.41492177
10Hypertensive crisis (HP:0100735)3.35640978
11Recurrent viral infections (HP:0004429)3.27278505
12Lymphopenia (HP:0001888)3.11685689
13Eczematoid dermatitis (HP:0000976)3.07560315
14Panhypogammaglobulinemia (HP:0003139)3.00006825
15Recurrent skin infections (HP:0001581)2.97620674
16IgM deficiency (HP:0002850)2.93458186
17Recurrent fungal infections (HP:0002841)2.92199860
18Abnormality of cells of the lymphoid lineage (HP:0012140)2.89786723
19Cellulitis (HP:0100658)2.89786200
20Colitis (HP:0002583)2.87949761
21Ragged-red muscle fibers (HP:0003200)2.87620659
22Microvesicular hepatic steatosis (HP:0001414)2.86169324
23Abnormality of macrophages (HP:0004311)2.84901646
24Gastrointestinal inflammation (HP:0004386)2.84566762
25Microretrognathia (HP:0000308)2.82147008
26Chronic mucocutaneous candidiasis (HP:0002728)2.81248211
27Recurrent cutaneous fungal infections (HP:0011370)2.81248211
28Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.80917758
29Decreased activity of mitochondrial respiratory chain (HP:0008972)2.80917758
30Abnormal delayed hypersensitivity skin test (HP:0002963)2.75630342
31Recurrent sinusitis (HP:0011108)2.72734747
32Progressive muscle weakness (HP:0003323)2.72163043
33Aplasia/Hypoplasia of the sacrum (HP:0008517)2.69278989
34Vasculitis (HP:0002633)2.65205116
35Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.57523366
36Inflammation of the large intestine (HP:0002037)2.57296336
37Squamous cell carcinoma (HP:0002860)2.57023662
38Abnormal number of erythroid precursors (HP:0012131)2.55646699
39Reticulocytopenia (HP:0001896)2.55221240
40Seborrheic dermatitis (HP:0001051)2.53420704
41Urticaria (HP:0001025)2.52899741
42Abnormality of cells of the erythroid lineage (HP:0012130)2.47459540
43Truncus arteriosus (HP:0001660)2.43982024
44Hypergonadotropic hypogonadism (HP:0000815)2.41202590
45Increased muscle lipid content (HP:0009058)2.37108681
46Abnormality of T cells (HP:0002843)2.35767167
47Recurrent lower respiratory tract infections (HP:0002783)2.35269966
48Aplasia/Hypoplasia of the thymus (HP:0010515)2.35260567
49IgG deficiency (HP:0004315)2.34908861
50Increased IgE level (HP:0003212)2.29994950
51Emphysema (HP:0002097)2.29228491
52Testicular atrophy (HP:0000029)2.28039035
53Congenital malformation of the right heart (HP:0011723)2.27415133
54Double outlet right ventricle (HP:0001719)2.27415133
55Cleft eyelid (HP:0000625)2.26882355
56Encephalitis (HP:0002383)2.25963505
57IgA deficiency (HP:0002720)2.21257664
58Increased intramyocellular lipid droplets (HP:0012240)2.19981573
59Verrucae (HP:0200043)2.19928027
60Papilloma (HP:0012740)2.19928027
61Petechiae (HP:0000967)2.19709750
62Skin rash (HP:0000988)2.18871627
63Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.17153981
64Premature ovarian failure (HP:0008209)2.14342835
653-Methylglutaconic aciduria (HP:0003535)2.09228438
66Recurrent bronchitis (HP:0002837)2.08839990
67Increased neuronal autofluorescent lipopigment (HP:0002074)2.08060379
68Abnormal mitochondria in muscle tissue (HP:0008316)2.08034529
69Osteomyelitis (HP:0002754)2.06741575
70Rough bone trabeculation (HP:0100670)2.05138097
71Stomatitis (HP:0010280)2.04358887
72Recurrent pneumonia (HP:0006532)2.03801208
73Pallor (HP:0000980)2.02725641
74Lymphoma (HP:0002665)2.02360426
75Leukopenia (HP:0001882)1.97454690
76Male infertility (HP:0003251)1.96799411
77Hepatosplenomegaly (HP:0001433)1.95090194
78Increased cerebral lipofuscin (HP:0011813)1.94218352
79Recurrent gram-negative bacterial infections (HP:0005420)1.94026847
80Progressive external ophthalmoplegia (HP:0000590)1.90289539
81Sepsis (HP:0100806)1.87624536
82Myositis (HP:0100614)1.86127336
83Viral hepatitis (HP:0006562)1.86122619
84Increased IgM level (HP:0003496)1.85717469
85Respiratory difficulties (HP:0002880)1.83922672
86Pustule (HP:0200039)1.81729899
87Basal cell carcinoma (HP:0002671)1.80989575
88Elevated erythrocyte sedimentation rate (HP:0003565)1.79358399
89Premature loss of primary teeth (HP:0006323)1.78776388
90Hypoplasia of the uterus (HP:0000013)1.78609708
91Reduced antithrombin III activity (HP:0001976)1.78014283
92Carpal bone hypoplasia (HP:0001498)1.77697853
93Increased serum lactate (HP:0002151)1.77329875
94Multiple enchondromatosis (HP:0005701)1.77231105
95Acute lymphatic leukemia (HP:0006721)1.76950281
96Neutropenia (HP:0001875)1.76614862
97Ureteral duplication (HP:0000073)1.76359575
98Increased serum ferritin (HP:0003281)1.75571298
99Restrictive lung disease (HP:0002091)1.74817342
100Mitochondrial inheritance (HP:0001427)1.72361421

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG13.94950495
2NME23.85172755
3VRK23.30067585
4RIPK43.06201823
5MAP4K12.88849782
6TESK22.77722620
7ERN12.67400075
8PRPF4B2.61283845
9BUB12.45919500
10STK162.24036368
11TXK2.21756167
12IRAK41.97240262
13BCKDK1.83191408
14TAOK21.64512663
15STK101.63291878
16IRAK31.62269701
17TBK11.59498497
18MAP3K101.57948293
19TLK11.53970227
20GRK61.47850303
21TRIB31.47591771
22BLK1.45738517
23VRK11.40402621
24AURKA1.35656824
25TYK21.32877513
26TAF11.32838618
27CSF1R1.32836824
28KDR1.30354412
29MAP3K141.28443410
30TNK21.18873346
31IKBKB1.17094474
32SIK21.14599625
33PIM21.13773580
34MAP3K111.11530439
35ZAK1.08834597
36CDK121.08753063
37ARAF1.08573735
38CDK191.07497946
39MAP2K31.06611256
40MAP3K81.04135448
41IKBKE0.99927958
42DAPK10.97507644
43SYK0.96884671
44MAPK110.92232583
45SIK10.90890258
46NME10.89801148
47BTK0.89711927
48STK40.88885467
49CDK40.88766045
50JAK30.87423341
51MAP3K130.81180703
52CHEK20.81014107
53MOS0.80729062
54CDC70.79067291
55MAP2K20.78883436
56LYN0.76334826
57CDK70.75908567
58LRRK20.74614555
59PRKD20.74532475
60SRPK10.73443408
61DYRK30.71633623
62IRAK20.71287718
63RPS6KA50.69131904
64TAOK10.68387041
65PIM10.66734592
66SIK30.65672304
67KIT0.65579927
68MAP3K10.65358762
69AURKB0.64605564
70MATK0.64197233
71PRKCI0.63585548
72DAPK30.59873956
73EEF2K0.58725235
74BRAF0.57852700
75MARK30.56128457
76CHEK10.55775273
77PAK10.54395808
78ATR0.53957611
79GRK70.53312493
80RPS6KB20.52778063
81CSK0.52584533
82BRSK10.52029972
83MAPKAPK20.49506889
84PDK10.48787882
85MAP3K30.48251826
86NUAK10.47937890
87TESK10.47756753
88RPS6KL10.47353095
89RPS6KC10.47353095
90PDPK10.45576863
91ABL20.45505773
92FES0.45310934
93CDK90.45263252
94TTK0.44389788
95MELK0.42744105
96HIPK20.41370821
97PRKCQ0.41348786
98GRK50.39817986
99PRKD30.39644685
100CSNK2A20.38917520

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.81953602
2DNA replication_Homo sapiens_hsa030303.32683964
3Primary immunodeficiency_Homo sapiens_hsa053402.87037078
4Sulfur relay system_Homo sapiens_hsa041222.76070872
5Allograft rejection_Homo sapiens_hsa053302.75981621
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.70990134
7Base excision repair_Homo sapiens_hsa034102.64233168
8Asthma_Homo sapiens_hsa053102.62525335
9Graft-versus-host disease_Homo sapiens_hsa053322.58843578
10Autoimmune thyroid disease_Homo sapiens_hsa053202.54040290
11Antigen processing and presentation_Homo sapiens_hsa046122.27631632
12Mismatch repair_Homo sapiens_hsa034302.18970966
13Systemic lupus erythematosus_Homo sapiens_hsa053222.15207348
14B cell receptor signaling pathway_Homo sapiens_hsa046622.05881171
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.02123867
16RNA polymerase_Homo sapiens_hsa030201.99074748
17Spliceosome_Homo sapiens_hsa030401.90625658
18Type I diabetes mellitus_Homo sapiens_hsa049401.88211071
19Leishmaniasis_Homo sapiens_hsa051401.87459047
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.85196792
21Pyrimidine metabolism_Homo sapiens_hsa002401.82764488
22Herpes simplex infection_Homo sapiens_hsa051681.82380563
23Viral myocarditis_Homo sapiens_hsa054161.74981022
24Proteasome_Homo sapiens_hsa030501.72976299
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.59972727
26Epstein-Barr virus infection_Homo sapiens_hsa051691.59476364
27Homologous recombination_Homo sapiens_hsa034401.54196721
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.48192527
29Staphylococcus aureus infection_Homo sapiens_hsa051501.23477093
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.23314710
31Influenza A_Homo sapiens_hsa051641.17514333
32Folate biosynthesis_Homo sapiens_hsa007901.15550484
33Viral carcinogenesis_Homo sapiens_hsa052031.13876980
34RNA transport_Homo sapiens_hsa030131.12639420
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.10819782
36Tuberculosis_Homo sapiens_hsa051521.09288709
37Oxidative phosphorylation_Homo sapiens_hsa001901.09076172
38Cell cycle_Homo sapiens_hsa041101.05565144
39Fanconi anemia pathway_Homo sapiens_hsa034601.02839186
40Osteoclast differentiation_Homo sapiens_hsa043801.01058952
41Parkinsons disease_Homo sapiens_hsa050121.00289516
42Toll-like receptor signaling pathway_Homo sapiens_hsa046200.96725488
43Acute myeloid leukemia_Homo sapiens_hsa052210.96385144
44HTLV-I infection_Homo sapiens_hsa051660.95372789
45Nucleotide excision repair_Homo sapiens_hsa034200.91097057
46Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90807541
47Measles_Homo sapiens_hsa051620.88001075
48Huntingtons disease_Homo sapiens_hsa050160.87288516
49Apoptosis_Homo sapiens_hsa042100.85986309
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85580382
51Rheumatoid arthritis_Homo sapiens_hsa053230.83583277
52Alcoholism_Homo sapiens_hsa050340.82211693
53Toxoplasmosis_Homo sapiens_hsa051450.81809699
54Pentose phosphate pathway_Homo sapiens_hsa000300.81653447
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80714724
56Hematopoietic cell lineage_Homo sapiens_hsa046400.78398961
57Fructose and mannose metabolism_Homo sapiens_hsa000510.77506472
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76906923
59p53 signaling pathway_Homo sapiens_hsa041150.74773169
60Basal transcription factors_Homo sapiens_hsa030220.74061623
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73052043
62Shigellosis_Homo sapiens_hsa051310.72885272
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.72257542
64Hepatitis B_Homo sapiens_hsa051610.71657305
65Purine metabolism_Homo sapiens_hsa002300.71170150
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68045170
67mRNA surveillance pathway_Homo sapiens_hsa030150.67668310
68Other glycan degradation_Homo sapiens_hsa005110.64315984
69Sulfur metabolism_Homo sapiens_hsa009200.61227373
70Regulation of autophagy_Homo sapiens_hsa041400.60927057
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59971454
72Biosynthesis of amino acids_Homo sapiens_hsa012300.59312782
73One carbon pool by folate_Homo sapiens_hsa006700.57276017
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53214571
75Alzheimers disease_Homo sapiens_hsa050100.50325653
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48753202
77Phagosome_Homo sapiens_hsa041450.48580595
78Galactose metabolism_Homo sapiens_hsa000520.47503482
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47362982
80RNA degradation_Homo sapiens_hsa030180.44967573
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.41726748
82Hepatitis C_Homo sapiens_hsa051600.40980867
83Notch signaling pathway_Homo sapiens_hsa043300.40931104
84Bladder cancer_Homo sapiens_hsa052190.39628894
85T cell receptor signaling pathway_Homo sapiens_hsa046600.37183802
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.33596389
87Lysosome_Homo sapiens_hsa041420.30036234
88Chemokine signaling pathway_Homo sapiens_hsa040620.29608039
89Non-small cell lung cancer_Homo sapiens_hsa052230.28977812
90Legionellosis_Homo sapiens_hsa051340.27469332
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.27402330
92Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.27124231
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.26234371
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24859595
95Pancreatic cancer_Homo sapiens_hsa052120.23846736
96Chronic myeloid leukemia_Homo sapiens_hsa052200.22859243
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.22656267
98Non-homologous end-joining_Homo sapiens_hsa034500.21933322
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19112962
100TNF signaling pathway_Homo sapiens_hsa046680.18122353

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