ZNF280A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a zinc finger protein. The encoded protein contains 4 C2H2-type zinc fingers, which are commonly found in transcription factors. A variety of functions may be performed by this type of zinc finger protein, including the binding of DNA or RNA. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of protein homooligomerization (GO:0032464)6.27462777
2transcription from mitochondrial promoter (GO:0006390)6.14986721
3rRNA modification (GO:0000154)5.54351263
4male meiosis I (GO:0007141)5.28174194
5regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.82323640
6meiosis I (GO:0007127)4.68336501
7rRNA methylation (GO:0031167)4.62660032
8response to UV-C (GO:0010225)4.59378834
9regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.53926086
10mitotic metaphase plate congression (GO:0007080)4.40350922
11mitochondrial RNA metabolic process (GO:0000959)4.06048266
12very-low-density lipoprotein particle assembly (GO:0034379)4.04720071
13chaperone-mediated protein transport (GO:0072321)4.04624770
14ventricular cardiac muscle cell development (GO:0055015)3.97313977
15autophagic vacuole assembly (GO:0000045)3.96520662
16maturation of SSU-rRNA (GO:0030490)3.87575144
17nuclear pore complex assembly (GO:0051292)3.84589951
18regulation of DNA methylation (GO:0044030)3.75992511
19ribosomal small subunit biogenesis (GO:0042274)3.72579718
20ribosome assembly (GO:0042255)3.71359163
21attachment of spindle microtubules to kinetochore (GO:0008608)3.69254256
22mitotic sister chromatid segregation (GO:0000070)3.66574753
23nuclear pore organization (GO:0006999)3.63291424
24mitotic chromosome condensation (GO:0007076)3.62619631
25maturation of 5.8S rRNA (GO:0000460)3.61215322
26regulation of spindle organization (GO:0090224)3.58958871
27male meiosis (GO:0007140)3.56219239
28regulation of G0 to G1 transition (GO:0070316)3.52313039
29metaphase plate congression (GO:0051310)3.49699444
30termination of RNA polymerase III transcription (GO:0006386)3.47428909
31transcription elongation from RNA polymerase III promoter (GO:0006385)3.47428909
32ribosome biogenesis (GO:0042254)3.45150972
33regulation of RNA export from nucleus (GO:0046831)3.43739418
34DNA replication initiation (GO:0006270)3.37516556
35regulation of meiosis I (GO:0060631)3.37112216
36DNA replication checkpoint (GO:0000076)3.35313800
37protein K6-linked ubiquitination (GO:0085020)3.34379985
38ribonucleoprotein complex biogenesis (GO:0022613)3.33455884
39sister chromatid segregation (GO:0000819)3.31923109
40regulation of mitotic spindle organization (GO:0060236)3.23744559
41rRNA processing (GO:0006364)3.18517432
42regulation of protein homooligomerization (GO:0032462)3.15840916
43rRNA metabolic process (GO:0016072)3.09637808
44protein localization to chromosome, centromeric region (GO:0071459)3.07353735
45mitotic nuclear envelope disassembly (GO:0007077)3.05294291
46positive regulation of chromosome segregation (GO:0051984)3.03889551
47formation of translation preinitiation complex (GO:0001731)3.03363117
48histone H3-K9 demethylation (GO:0033169)3.01450252
49negative regulation of retinoic acid receptor signaling pathway (GO:0048387)24.6615424
50regulation of retinoic acid receptor signaling pathway (GO:0048385)20.7439845
51negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.99437200
52skeletal muscle tissue regeneration (GO:0043403)2.98217339
53regulation of exit from mitosis (GO:0007096)2.96237461
54meiotic cell cycle process (GO:1903046)2.95197844
55N-terminal protein amino acid acetylation (GO:0006474)2.95017493
56membrane disassembly (GO:0030397)2.91794886
57nuclear envelope disassembly (GO:0051081)2.91794886
58regulation of oxidative phosphorylation (GO:0002082)2.89933598
59ribosomal large subunit biogenesis (GO:0042273)2.88059657
60regulation of translational fidelity (GO:0006450)2.84260604
61positive regulation of protein oligomerization (GO:0032461)2.83175769
62DNA synthesis involved in DNA repair (GO:0000731)2.81827958
63pore complex assembly (GO:0046931)2.80789668
64replication fork processing (GO:0031297)2.79573100
65negative regulation of RNA splicing (GO:0033119)2.79241298
66meiotic cell cycle (GO:0051321)2.78688645
67histone mRNA metabolic process (GO:0008334)2.78644242
68activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.78564155
69pseudouridine synthesis (GO:0001522)2.78560844
70multicellular organism reproduction (GO:0032504)2.77824005
71negative regulation of mRNA processing (GO:0050686)2.77410232
72negative regulation of mRNA metabolic process (GO:1903312)2.76536950
73transcription from RNA polymerase III promoter (GO:0006383)2.75624612
74protein targeting to mitochondrion (GO:0006626)2.72336153
75regulation of mitochondrial translation (GO:0070129)2.70805584
76DNA methylation involved in gamete generation (GO:0043046)2.68341824
77snRNA transcription (GO:0009301)2.66452581
78meiotic nuclear division (GO:0007126)2.64120315
79kinetochore organization (GO:0051383)2.61766790
80telomere maintenance via telomere lengthening (GO:0010833)2.61428885
81kinetochore assembly (GO:0051382)2.60167677
82regulation of nucleobase-containing compound transport (GO:0032239)2.60080544
83translational initiation (GO:0006413)2.59497184
84CENP-A containing nucleosome assembly (GO:0034080)2.59258161
85regulation of chromosome segregation (GO:0051983)2.57601498
86regulation of acrosome reaction (GO:0060046)2.57313476
87cellular component biogenesis (GO:0044085)2.56126845
88negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.55599366
89DNA-templated transcription, termination (GO:0006353)2.53998417
90termination of RNA polymerase II transcription (GO:0006369)2.53416833
91exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.53375993
92DNA unwinding involved in DNA replication (GO:0006268)2.51104821
93translational termination (GO:0006415)2.50569637
94regulation of double-strand break repair via homologous recombination (GO:0010569)2.50318660
95transcription elongation from RNA polymerase II promoter (GO:0006368)2.50163123
96resolution of meiotic recombination intermediates (GO:0000712)2.48830156
97terpenoid biosynthetic process (GO:0016114)2.46798347
98ncRNA processing (GO:0034470)2.46771066
99nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.46268532
100meiotic chromosome segregation (GO:0045132)2.45742001

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.85977316
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.53632262
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.85204845
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.77422363
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.59213431
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.38039596
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.36268515
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.33093893
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.13722758
10MYC_18555785_ChIP-Seq_MESCs_Mouse3.12739296
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.97826274
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.96737905
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.94689068
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.71017642
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.68714418
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.66397146
17KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.52769176
18KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.52769176
19KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.52769176
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.44378724
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.41729737
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.38648106
23ZNF263_19887448_ChIP-Seq_K562_Human2.34510724
24TTF2_22483619_ChIP-Seq_HELA_Human2.22158931
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.22038564
26MYC_19079543_ChIP-ChIP_MESCs_Mouse2.20169994
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.15413393
28AR_21909140_ChIP-Seq_LNCAP_Human2.12561750
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.10109796
30VDR_23849224_ChIP-Seq_CD4+_Human2.09814291
31XRN2_22483619_ChIP-Seq_HELA_Human2.09202705
32GABP_19822575_ChIP-Seq_HepG2_Human2.07460128
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.05859777
34NELFA_20434984_ChIP-Seq_ESCs_Mouse2.00176134
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.89228127
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88343165
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.85431166
38RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85193089
39FOXP3_21729870_ChIP-Seq_TREG_Human1.82769781
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79326598
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.75580397
42ELK1_19687146_ChIP-ChIP_HELA_Human1.70876567
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.70305964
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65562950
45DCP1A_22483619_ChIP-Seq_HELA_Human1.65258079
46ZNF274_21170338_ChIP-Seq_K562_Hela1.63553933
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55172723
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54490546
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54364421
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48677035
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.48197815
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43707723
53KDM5A_27292631_Chip-Seq_BREAST_Human1.43421082
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.40005153
55KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.37169813
56ETV1_20927104_ChIP-Seq_GIST48_Human1.35988051
57RBPJ_21746931_ChIP-Seq_IB4_Human1.34437907
58MYC_18940864_ChIP-ChIP_HL60_Human1.30755773
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28177714
60PHF8_20622853_ChIP-Seq_HELA_Human1.27661814
61PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.27320285
62CIITA_25753668_ChIP-Seq_RAJI_Human1.26551001
63CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.23956434
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.23561088
65GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.23368049
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21483985
67GATA6_21074721_ChIP-Seq_CACO-2_Human1.21123339
68E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.18284937
69SALL1_21062744_ChIP-ChIP_HESCs_Human1.17634582
70CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.17603828
71SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14791873
72E2F1_21310950_ChIP-Seq_MCF-7_Human1.14326700
73* NCOR1_26117541_ChIP-Seq_K562_Human1.12826500
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11832081
75NFYB_21822215_ChIP-Seq_K562_Human1.10637649
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07822517
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07375109
78TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06817048
79MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04071533
80EGR1_19374776_ChIP-ChIP_THP-1_Human1.02244014
81SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01908128
82ZFX_18555785_ChIP-Seq_MESCs_Mouse1.01234703
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00376629
84SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99178498
85FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98921316
86NANOG_18555785_ChIP-Seq_MESCs_Mouse0.98562768
87E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98177868
88HNFA_21074721_ChIP-Seq_CACO-2_Human0.97417435
89STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96882371
90CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94351467
91TFEB_21752829_ChIP-Seq_HELA_Human0.93180195
92LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.91022599
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91004246
94KAP1_22055183_ChIP-Seq_ESCs_Mouse0.87502222
95TBL1_22424771_ChIP-Seq_293T_Human0.87353898
96ERG_20887958_ChIP-Seq_HPC-7_Mouse0.83328054
97ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.82447557
98ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.82368382
99NFYA_21822215_ChIP-Seq_K562_Human0.79344173
100PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.78715034

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity6.56213779
2MP0005423_abnormal_somatic_nervous5.10329390
3MP0003693_abnormal_embryo_hatching4.13858245
4MP0004957_abnormal_blastocyst_morpholog3.86432878
5MP0006292_abnormal_olfactory_placode3.83216362
6MP0003718_maternal_effect3.81774012
7MP0003111_abnormal_nucleus_morphology3.56207988
8MP0008995_early_reproductive_senescence3.31779893
9MP0003646_muscle_fatigue3.14818274
10MP0008260_abnormal_autophagy3.04932264
11MP0008058_abnormal_DNA_repair2.99269110
12MP0010094_abnormal_chromosome_stability2.88673032
13MP0003077_abnormal_cell_cycle2.66981721
14MP0009379_abnormal_foot_pigmentation2.58609220
15MP0003786_premature_aging2.32811417
16MP0009333_abnormal_splenocyte_physiolog2.13543724
17MP0000678_abnormal_parathyroid_gland2.08508421
18MP0010307_abnormal_tumor_latency2.06792165
19MP0001929_abnormal_gametogenesis2.05583208
20MP0002210_abnormal_sex_determination2.00273854
21MP0008932_abnormal_embryonic_tissue1.99739844
22MP0005451_abnormal_body_composition1.88305118
23MP0006036_abnormal_mitochondrial_physio1.79243077
24MP0008877_abnormal_DNA_methylation1.72157824
25MP0009840_abnormal_foam_cell1.69861037
26MP0001730_embryonic_growth_arrest1.69442420
27MP0001672_abnormal_embryogenesis/_devel1.65099712
28MP0005380_embryogenesis_phenotype1.65099712
29MP0002160_abnormal_reproductive_system1.64698365
30MP0001697_abnormal_embryo_size1.54276126
31MP0002127_abnormal_cardiovascular_syste1.53962985
32MP0005410_abnormal_fertilization1.51956380
33MP0003136_yellow_coat_color1.51044133
34MP0006035_abnormal_mitochondrial_morpho1.50113194
35MP0000350_abnormal_cell_proliferation1.46844128
36MP0003984_embryonic_growth_retardation1.45548748
37MP0002088_abnormal_embryonic_growth/wei1.39425635
38MP0000372_irregular_coat_pigmentation1.36035341
39MP0000653_abnormal_sex_gland1.35022371
40MP0000358_abnormal_cell_content/1.29377545
41MP0005389_reproductive_system_phenotype1.29121098
42MP0001145_abnormal_male_reproductive1.28106942
43MP0003698_abnormal_male_reproductive1.26339168
44MP0008057_abnormal_DNA_replication1.23726387
45MP0003186_abnormal_redox_activity1.23152087
46MP0005395_other_phenotype1.22734202
47MP0001666_abnormal_nutrient_absorption1.22578434
48MP0003699_abnormal_female_reproductive1.16639969
49MP0002080_prenatal_lethality1.15053778
50MP0003938_abnormal_ear_development1.14395336
51MP0002161_abnormal_fertility/fecundity1.09797555
52MP0004019_abnormal_vitamin_homeostasis1.09723823
53MP0000313_abnormal_cell_death1.09514198
54MP0002085_abnormal_embryonic_tissue1.05564738
55MP0005647_abnormal_sex_gland1.05223994
56MP0001881_abnormal_mammary_gland1.04917926
57MP0002084_abnormal_developmental_patter0.96925022
58MP0002086_abnormal_extraembryonic_tissu0.96903187
59MP0005397_hematopoietic_system_phenotyp0.94726923
60MP0001545_abnormal_hematopoietic_system0.94726923
61MP0003195_calcinosis0.92383542
62MP0001661_extended_life_span0.91951984
63MP0002277_abnormal_respiratory_mucosa0.91461224
64MP0001293_anophthalmia0.90977247
65MP0010030_abnormal_orbit_morphology0.90671099
66MP0000490_abnormal_crypts_of0.88897447
67MP0001502_abnormal_circadian_rhythm0.88832701
68MP0001119_abnormal_female_reproductive0.88435715
69MP0004147_increased_porphyrin_level0.88200085
70MP0003890_abnormal_embryonic-extraembry0.87351590
71MP0009697_abnormal_copulation0.85779029
72MP0005394_taste/olfaction_phenotype0.83352662
73MP0005499_abnormal_olfactory_system0.83352662
74MP0008007_abnormal_cellular_replicative0.76489016
75MP0003943_abnormal_hepatobiliary_system0.74215761
76MP0001919_abnormal_reproductive_system0.73251414
77MP0003936_abnormal_reproductive_system0.70813970
78MP0003119_abnormal_digestive_system0.70381076
79MP0004215_abnormal_myocardial_fiber0.70260241
80MP0002132_abnormal_respiratory_system0.70156011
81MP0000750_abnormal_muscle_regeneration0.69114483
82MP0001286_abnormal_eye_development0.64785080
83MP0005083_abnormal_biliary_tract0.64493067
84MP0005058_abnormal_lysosome_morphology0.62705262
85MP0002269_muscular_atrophy0.62313824
86MP0000015_abnormal_ear_pigmentation0.62048837
87MP0001529_abnormal_vocalization0.59691225
88MP0002638_abnormal_pupillary_reflex0.58333665
89MP0000631_abnormal_neuroendocrine_gland0.58133893
90MP0008775_abnormal_heart_ventricle0.58036578
91MP0008789_abnormal_olfactory_epithelium0.56442411
92MP0000647_abnormal_sebaceous_gland0.55408783
93MP0002396_abnormal_hematopoietic_system0.54578056
94MP0000462_abnormal_digestive_system0.54573762
95MP0006276_abnormal_autonomic_nervous0.54272136
96MP0002095_abnormal_skin_pigmentation0.53820797
97MP0002873_normal_phenotype0.49732010
98MP0002169_no_abnormal_phenotype0.49521863
99MP0000049_abnormal_middle_ear0.48680375
100MP0005636_abnormal_mineral_homeostasis0.47350910

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)6.01123860
2Birth length less than 3rd percentile (HP:0003561)5.45742771
3Ureteral duplication (HP:0000073)4.32270886
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.12646045
5Truncus arteriosus (HP:0001660)4.06262844
6Congenital malformation of the right heart (HP:0011723)4.04903204
7Double outlet right ventricle (HP:0001719)4.04903204
8Chromsome breakage (HP:0040012)3.97910558
9Premature ovarian failure (HP:0008209)3.79096914
10Abnormal umbilical cord blood vessels (HP:0011403)3.53477359
11Single umbilical artery (HP:0001195)3.53477359
12Abnormality of the fetal cardiovascular system (HP:0010948)3.53477359
13Microvesicular hepatic steatosis (HP:0001414)3.48650103
14Increased serum pyruvate (HP:0003542)3.37821645
15Patent foramen ovale (HP:0001655)3.35523328
16Reticulocytopenia (HP:0001896)3.33257171
17Abnormal pancreas size (HP:0012094)3.21825749
18Pili torti (HP:0003777)3.10763404
19Ileus (HP:0002595)3.05199430
20Abnormality of the preputium (HP:0100587)3.04168163
21Abnormality of the aortic arch (HP:0012303)2.97759392
22Hypergonadotropic hypogonadism (HP:0000815)2.95556532
23Meckel diverticulum (HP:0002245)2.95040674
24Aplasia/hypoplasia of the uterus (HP:0008684)2.94665179
25Abnormality of glycolysis (HP:0004366)2.92506862
26Concave nail (HP:0001598)2.88240317
27Carpal bone hypoplasia (HP:0001498)2.83506039
28Hypoplasia of the uterus (HP:0000013)2.80006890
29Abnormality of the ileum (HP:0001549)2.79030245
30Abnormality of the umbilical cord (HP:0010881)2.73232841
31Increased hepatocellular lipid droplets (HP:0006565)2.68558464
32Progressive muscle weakness (HP:0003323)2.63396931
33Secondary amenorrhea (HP:0000869)2.57392604
34Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.54393546
35Horseshoe kidney (HP:0000085)2.54317511
36Aplasia/Hypoplasia of the uvula (HP:0010293)2.51905390
37Duplicated collecting system (HP:0000081)2.50395228
38Increased CSF lactate (HP:0002490)2.47476641
39Lipid accumulation in hepatocytes (HP:0006561)2.47054112
40Rough bone trabeculation (HP:0100670)2.45966748
41Increased serum lactate (HP:0002151)2.45125193
42Submucous cleft hard palate (HP:0000176)2.44704579
43Abnormality of the renal collecting system (HP:0004742)2.39551534
44Absent thumb (HP:0009777)2.39249593
45Breast hypoplasia (HP:0003187)2.39044219
46Abnormality of alanine metabolism (HP:0010916)2.34892044
47Hyperalaninemia (HP:0003348)2.34892044
48Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.34892044
49Respiratory difficulties (HP:0002880)2.34638535
50Absent radius (HP:0003974)2.34024681
51Entropion (HP:0000621)2.29277619
52Abnormality of chromosome stability (HP:0003220)2.26955151
53Aplasia/Hypoplasia involving the musculature (HP:0001460)2.26077512
54Abnormality of the septum pellucidum (HP:0007375)2.22672770
55Preauricular pit (HP:0004467)2.21451881
56Periauricular skin pits (HP:0100277)2.21451881
57Hyperglycemia (HP:0003074)2.21377889
58Short tibia (HP:0005736)2.21237677
59Renal Fanconi syndrome (HP:0001994)2.18856830
60Absent forearm bone (HP:0003953)2.18467488
61Aplasia involving forearm bones (HP:0009822)2.18467488
62Hypercortisolism (HP:0001578)2.16292708
63Abnormality of homocysteine metabolism (HP:0010919)2.16177359
64Homocystinuria (HP:0002156)2.16177359
65Glycosuria (HP:0003076)2.15684628
66Abnormality of urine glucose concentration (HP:0011016)2.15684628
67Ectopic kidney (HP:0000086)2.14441710
68Abnormal hair laboratory examination (HP:0003328)2.11478834
69Cholecystitis (HP:0001082)2.11354849
70Abnormal gallbladder physiology (HP:0012438)2.11354849
71Abnormality of DNA repair (HP:0003254)2.09645554
72Myopathic facies (HP:0002058)2.08003875
73Microretrognathia (HP:0000308)2.07199974
74Infertility (HP:0000789)2.07105121
75Abnormal lung lobation (HP:0002101)2.03575273
76Absent rod-and cone-mediated responses on ERG (HP:0007688)2.02248501
77Symptomatic seizures (HP:0011145)1.99962622
78Small intestinal stenosis (HP:0012848)1.99022026
79Duodenal stenosis (HP:0100867)1.99022026
80Abnormality of reticulocytes (HP:0004312)1.98168587
81Aplasia/Hypoplasia of the tibia (HP:0005772)1.97528669
82Abnormality of cells of the erythroid lineage (HP:0012130)1.96320988
83Hypoplasia of the pons (HP:0012110)1.96235204
84Testicular atrophy (HP:0000029)1.95493615
85Ragged-red muscle fibers (HP:0003200)1.94952286
86Multiple enchondromatosis (HP:0005701)1.93440936
87Abnormality of the pons (HP:0007361)1.92396713
88Pallor (HP:0000980)1.91503771
89Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.90483428
90Abnormal number of incisors (HP:0011064)1.90458033
91Dysautonomia (HP:0002459)1.89160054
92Hyperinsulinemic hypoglycemia (HP:0000825)1.88917626
93Abnormalities of placenta or umbilical cord (HP:0001194)1.87723974
94Severe visual impairment (HP:0001141)1.87644208
95Transposition of the great arteries (HP:0001669)1.84154166
96Abnormal connection of the cardiac segments (HP:0011545)1.84154166
97Abnormal ventriculo-arterial connection (HP:0011563)1.84154166
98Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.79630346
99Abnormal trabecular bone morphology (HP:0100671)1.78098550
100Cerebral hypomyelination (HP:0006808)1.77947353

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.16132397
2PDK24.18603744
3SRPK13.71914624
4EIF2AK13.26666841
5BRSK22.88362040
6PBK2.79196079
7LATS22.78610258
8STK162.67341427
9BRSK12.64768665
10TESK22.59369404
11TTK2.52268406
12TAOK32.16210035
13NUAK12.16138054
14PLK42.09393965
15NEK22.04557615
16PLK12.03675694
17BMX1.93324633
18EIF2AK31.92807296
19RAF11.90283094
20PLK31.86521944
21AURKA1.81804532
22NME11.80161229
23CHEK21.78324476
24CDC71.61984400
25AURKB1.60631334
26MARK31.59381369
27TRIM281.55264811
28CLK11.49380368
29CHEK11.43381786
30NTRK31.42618966
31DYRK31.30547890
32KSR21.27442417
33CDK191.18779755
34STK41.17534105
35WEE11.12481113
36ATR1.11926084
37NEK11.09325343
38NEK61.06298303
39CCNB11.01168702
40PAK10.97152690
41CSNK2A10.95420690
42MAP3K20.94684430
43CSNK2A20.89230473
44CDK10.88309449
45RIPK40.88121327
46ATM0.87762574
47CSNK1E0.87352041
48CDK120.87294893
49MAP3K80.85396028
50PIM10.84108255
51STK30.81857105
52CDK70.81344793
53CDK20.80479105
54PAK20.76989532
55CAMK1D0.74756803
56BMPR20.74689456
57PKN10.74144189
58DMPK0.67892104
59NME20.64314407
60MAPK110.60502295
61ZAK0.59221328
62LRRK20.58180365
63KSR10.56366853
64PINK10.53291898
65ERBB40.51384738
66MST40.49542518
67ILK0.49411305
68STK100.48633691
69WNK30.48210867
70PAK60.48091834
71AKT20.48020472
72MTOR0.45991749
73MAP3K40.45889264
74GSK3B0.45207481
75PRKACB0.45190896
76PRKCI0.45032297
77GSK3A0.41226573
78PRKAA10.40615248
79TSSK60.40412691
80MAPK10.39881309
81CAMK1G0.38596703
82WNK10.36894379
83CDK90.35631293
84ACVR1B0.35503996
85RPS6KA10.34978560
86MAP2K10.34645338
87VRK10.34378743
88RPS6KB20.34276114
89MAPK140.33393944
90PRKG10.30706554
91ALK0.30314968
92EIF2AK20.29898005
93WNK40.28791307
94TLK10.27174976
95MAPK100.26861150
96EPHA40.25865524
97MELK0.25595227
98MAPKAPK20.25292360
99CSNK1A10.24813910
100PRKAA20.24664606

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.90164410
2Ribosome_Homo sapiens_hsa030104.02875652
3RNA polymerase_Homo sapiens_hsa030203.74032809
4Basal transcription factors_Homo sapiens_hsa030223.66607562
5RNA transport_Homo sapiens_hsa030133.27712924
6Regulation of autophagy_Homo sapiens_hsa041403.13407421
7Spliceosome_Homo sapiens_hsa030403.10275109
8DNA replication_Homo sapiens_hsa030302.81037293
9Homologous recombination_Homo sapiens_hsa034402.75434513
10Mismatch repair_Homo sapiens_hsa034302.70033949
11mRNA surveillance pathway_Homo sapiens_hsa030152.68094873
12Steroid biosynthesis_Homo sapiens_hsa001002.43736408
13Cell cycle_Homo sapiens_hsa041102.34577330
14Fanconi anemia pathway_Homo sapiens_hsa034602.22602436
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.98051399
16Pyrimidine metabolism_Homo sapiens_hsa002401.90715456
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.87851506
18RNA degradation_Homo sapiens_hsa030181.86711942
19One carbon pool by folate_Homo sapiens_hsa006701.82905275
20Oocyte meiosis_Homo sapiens_hsa041141.81566430
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.73815018
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.67831268
23Base excision repair_Homo sapiens_hsa034101.64552531
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.53700452
25Proteasome_Homo sapiens_hsa030501.51643811
26Nucleotide excision repair_Homo sapiens_hsa034201.50346795
27p53 signaling pathway_Homo sapiens_hsa041151.43489161
28Selenocompound metabolism_Homo sapiens_hsa004501.43455878
29Parkinsons disease_Homo sapiens_hsa050121.43382077
30Huntingtons disease_Homo sapiens_hsa050161.42088319
31Folate biosynthesis_Homo sapiens_hsa007901.37293701
32Oxidative phosphorylation_Homo sapiens_hsa001901.19814916
33Fatty acid biosynthesis_Homo sapiens_hsa000611.18788808
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.14848267
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.14609674
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07943732
37Purine metabolism_Homo sapiens_hsa002301.05926772
38Protein export_Homo sapiens_hsa030601.05488650
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03466330
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.03230477
41SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96567722
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81527955
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81247053
44Fructose and mannose metabolism_Homo sapiens_hsa000510.80758366
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77631323
46Olfactory transduction_Homo sapiens_hsa047400.75422733
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73711771
48Maturity onset diabetes of the young_Homo sapiens_hsa049500.73456789
49Taste transduction_Homo sapiens_hsa047420.69018283
50Cardiac muscle contraction_Homo sapiens_hsa042600.68241187
51Glutathione metabolism_Homo sapiens_hsa004800.67985397
52Inositol phosphate metabolism_Homo sapiens_hsa005620.66408338
53Fatty acid elongation_Homo sapiens_hsa000620.66181772
54Pyruvate metabolism_Homo sapiens_hsa006200.66013231
55Viral carcinogenesis_Homo sapiens_hsa052030.59132037
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58772358
57Epstein-Barr virus infection_Homo sapiens_hsa051690.58355425
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.52358744
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50793081
60Arginine and proline metabolism_Homo sapiens_hsa003300.49056227
61Metabolic pathways_Homo sapiens_hsa011000.47077891
62Alzheimers disease_Homo sapiens_hsa050100.45222933
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43327970
64MicroRNAs in cancer_Homo sapiens_hsa052060.42302192
65Non-homologous end-joining_Homo sapiens_hsa034500.40028288
66Arginine biosynthesis_Homo sapiens_hsa002200.39672510
67Herpes simplex infection_Homo sapiens_hsa051680.35034235
68Sulfur metabolism_Homo sapiens_hsa009200.34797203
69Dorso-ventral axis formation_Homo sapiens_hsa043200.34652282
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31745809
71Vitamin B6 metabolism_Homo sapiens_hsa007500.31469838
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.31432612
73Ovarian steroidogenesis_Homo sapiens_hsa049130.31245860
74Biosynthesis of amino acids_Homo sapiens_hsa012300.29038477
75Nitrogen metabolism_Homo sapiens_hsa009100.26918623
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.26397058
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.25268835
78Vitamin digestion and absorption_Homo sapiens_hsa049770.23328826
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.23138538
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.21000201
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20684470
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.18610325
83Wnt signaling pathway_Homo sapiens_hsa043100.17675097
84Sulfur relay system_Homo sapiens_hsa041220.16143142
85HIF-1 signaling pathway_Homo sapiens_hsa040660.15880337
86Acute myeloid leukemia_Homo sapiens_hsa052210.15198879
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.14855609
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.12275429
89Circadian rhythm_Homo sapiens_hsa047100.12195642
90Carbon metabolism_Homo sapiens_hsa012000.10815068
91Mineral absorption_Homo sapiens_hsa049780.10170747
92Fat digestion and absorption_Homo sapiens_hsa049750.09399361
93Fatty acid metabolism_Homo sapiens_hsa012120.09272670
94TGF-beta signaling pathway_Homo sapiens_hsa043500.08388178
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.08157861
96Systemic lupus erythematosus_Homo sapiens_hsa053220.07746187
97Apoptosis_Homo sapiens_hsa042100.06622149
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.06338172
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.05924802
100Hepatitis B_Homo sapiens_hsa051610.05613372

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