ZNF271P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Zinc finger proteins interact with nucleic acids and have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See ZFP93 (MIM 604749) for additional information on zinc finger proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)6.16342147
2DNA double-strand break processing (GO:0000729)4.19598709
3protein K6-linked ubiquitination (GO:0085020)4.01561086
4protein complex biogenesis (GO:0070271)3.88856425
5dopamine transport (GO:0015872)3.87804025
6response to pheromone (GO:0019236)3.81580129
7platelet dense granule organization (GO:0060155)3.77430449
8regulation of hexokinase activity (GO:1903299)3.64149901
9regulation of glucokinase activity (GO:0033131)3.64149901
10mitochondrial respiratory chain complex assembly (GO:0033108)3.56766609
11water-soluble vitamin biosynthetic process (GO:0042364)3.43784175
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.43433892
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.42554862
14mitochondrial respiratory chain complex I assembly (GO:0032981)3.42554862
15NADH dehydrogenase complex assembly (GO:0010257)3.42554862
16nonmotile primary cilium assembly (GO:0035058)3.41554126
17negative regulation of heart rate (GO:0010459)3.41313260
18respiratory chain complex IV assembly (GO:0008535)3.33916443
19negative regulation of appetite (GO:0032099)3.33130876
20negative regulation of response to food (GO:0032096)3.33130876
21signal peptide processing (GO:0006465)3.25475528
22intraciliary transport (GO:0042073)3.17722375
23cytochrome complex assembly (GO:0017004)3.16031740
24regulation of cilium movement (GO:0003352)3.13915340
25epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.02535274
26L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.00275608
27adenosine metabolic process (GO:0046085)2.99247748
28epithelial cilium movement (GO:0003351)2.97387970
29replication fork processing (GO:0031297)2.96072203
30detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.95863631
31establishment of protein localization to mitochondrial membrane (GO:0090151)2.94474837
32protein prenylation (GO:0018342)2.93652672
33prenylation (GO:0097354)2.93652672
34nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.90460576
35cullin deneddylation (GO:0010388)2.87386721
36mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.85299973
37limb bud formation (GO:0060174)2.84311835
38centriole replication (GO:0007099)2.81540062
39double-strand break repair via homologous recombination (GO:0000724)2.80460433
40recombinational repair (GO:0000725)2.79170356
41positive regulation of mitochondrial fission (GO:0090141)2.78075705
42exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.77462749
43DNA deamination (GO:0045006)2.77072944
44lactate metabolic process (GO:0006089)2.75728992
45negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.74562030
46cilium organization (GO:0044782)2.73300539
47protein-cofactor linkage (GO:0018065)2.70505250
48cilium assembly (GO:0042384)2.70293652
49histone H2A acetylation (GO:0043968)2.70276709
50detection of light stimulus involved in sensory perception (GO:0050962)2.69663513
51detection of light stimulus involved in visual perception (GO:0050908)2.69663513
52anterograde synaptic vesicle transport (GO:0048490)2.68455643
53electron transport chain (GO:0022900)2.66984933
54positive regulation of protein homodimerization activity (GO:0090073)2.66229890
55respiratory electron transport chain (GO:0022904)2.64690634
56proteasome assembly (GO:0043248)2.64384797
57cilium morphogenesis (GO:0060271)2.64277798
58neural tube formation (GO:0001841)2.63465184
59peptidyl-histidine modification (GO:0018202)2.62347270
60chromatin remodeling at centromere (GO:0031055)2.61414513
61L-methionine salvage (GO:0071267)2.60960535
62L-methionine biosynthetic process (GO:0071265)2.60960535
63amino acid salvage (GO:0043102)2.60960535
64branched-chain amino acid catabolic process (GO:0009083)2.60121248
65glycosphingolipid biosynthetic process (GO:0006688)2.59631550
66pyrimidine nucleobase catabolic process (GO:0006208)2.58956320
67protein deneddylation (GO:0000338)2.56662918
68sequestering of actin monomers (GO:0042989)2.55942288
69photoreceptor cell maintenance (GO:0045494)2.55440595
70axoneme assembly (GO:0035082)2.53480313
71regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.52304496
72tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.51285473
73RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.51285473
74ATP synthesis coupled proton transport (GO:0015986)2.48265899
75energy coupled proton transport, down electrochemical gradient (GO:0015985)2.48265899
76neurotransmitter uptake (GO:0001504)2.47688081
77CENP-A containing nucleosome assembly (GO:0034080)2.47041068
78DNA catabolic process, exonucleolytic (GO:0000738)2.46958789
79nitric oxide mediated signal transduction (GO:0007263)2.46597291
80somite development (GO:0061053)2.44296415
81postreplication repair (GO:0006301)2.42333261
82inositol phosphate catabolic process (GO:0071545)2.40717979
83xenobiotic catabolic process (GO:0042178)2.39031169
84negative regulation of membrane potential (GO:0045837)2.38428853
85preassembly of GPI anchor in ER membrane (GO:0016254)2.36972699
86behavioral response to nicotine (GO:0035095)2.36793738
87negative regulation of transcription regulatory region DNA binding (GO:2000678)2.35195031
88protein localization to cilium (GO:0061512)2.33148835
89retinal cone cell development (GO:0046549)2.32163158
90negative regulation of DNA-dependent DNA replication (GO:2000104)2.30799849
91peroxisome fission (GO:0016559)2.30762793
92L-fucose catabolic process (GO:0042355)2.30443865
93fucose catabolic process (GO:0019317)2.30443865
94L-fucose metabolic process (GO:0042354)2.30443865
95regulation of integrin-mediated signaling pathway (GO:2001044)2.30031174
96positive regulation of amino acid transport (GO:0051957)2.29911375
97nucleobase catabolic process (GO:0046113)2.28524177
98positive regulation of oligodendrocyte differentiation (GO:0048714)2.27927808
99cilium movement (GO:0003341)2.27682086
100magnesium ion transport (GO:0015693)2.27654715

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1POU3F2_20337985_ChIP-ChIP_501MEL_Human2.95983174
2GBX2_23144817_ChIP-Seq_PC3_Human2.92075276
3ZNF274_21170338_ChIP-Seq_K562_Hela2.76634872
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.74247048
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.71680211
6VDR_22108803_ChIP-Seq_LS180_Human2.62456459
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.62376309
8TAF15_26573619_Chip-Seq_HEK293_Human2.49349304
9EWS_26573619_Chip-Seq_HEK293_Human2.46200810
10IGF1R_20145208_ChIP-Seq_DFB_Human2.38950568
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.38703833
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.36213061
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.34143416
14FUS_26573619_Chip-Seq_HEK293_Human2.29322331
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.26074245
16P300_19829295_ChIP-Seq_ESCs_Human2.25274571
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.22635519
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.18190984
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.17696162
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.08193567
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.07523996
22EZH2_22144423_ChIP-Seq_EOC_Human2.07179292
23ELK1_19687146_ChIP-ChIP_HELA_Human2.03532895
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00299607
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81069235
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.79978048
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77975794
28SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.75122870
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.71391097
30ER_23166858_ChIP-Seq_MCF-7_Human1.67039004
31UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60532877
32SMAD4_21799915_ChIP-Seq_A2780_Human1.60081414
33OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59861277
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.56332892
35EZH2_27294783_Chip-Seq_NPCs_Mouse1.55682064
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.52483560
37SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50825078
38BCAT_22108803_ChIP-Seq_LS180_Human1.47994138
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.44421001
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44008457
41TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41167285
42MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40748265
43RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.40747180
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38872892
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37738596
46NANOG_18555785_Chip-Seq_ESCs_Mouse1.37543099
47SOX2_19829295_ChIP-Seq_ESCs_Human1.37364395
48NANOG_19829295_ChIP-Seq_ESCs_Human1.37364395
49VDR_23849224_ChIP-Seq_CD4+_Human1.36237124
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.35192709
51AR_25329375_ChIP-Seq_VCAP_Human1.35117911
52EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.34298727
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34208664
54STAT3_23295773_ChIP-Seq_U87_Human1.33153412
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32398312
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32187668
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31754615
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30272720
59CBP_20019798_ChIP-Seq_JUKART_Human1.30272720
60MYC_18940864_ChIP-ChIP_HL60_Human1.29076423
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27894631
62TCF4_22108803_ChIP-Seq_LS180_Human1.27794019
63P53_22387025_ChIP-Seq_ESCs_Mouse1.27139440
64TP53_22573176_ChIP-Seq_HFKS_Human1.27086160
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26560964
66CRX_20693478_ChIP-Seq_RETINA_Mouse1.24761690
67TCF4_23295773_ChIP-Seq_U87_Human1.24269348
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.22804084
69HTT_18923047_ChIP-ChIP_STHdh_Human1.21130339
70IRF1_19129219_ChIP-ChIP_H3396_Human1.20906599
71RNF2_27304074_Chip-Seq_NSC_Mouse1.19731181
72KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19436323
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17267544
74CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15840353
75E2F1_18555785_Chip-Seq_ESCs_Mouse1.14914032
76TAL1_26923725_Chip-Seq_HPCs_Mouse1.12508972
77RUNX2_22187159_ChIP-Seq_PCA_Human1.12339700
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10919045
79JUN_21703547_ChIP-Seq_K562_Human1.10270684
80FLI1_21867929_ChIP-Seq_TH2_Mouse1.09946149
81PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09933255
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.09522157
83STAT3_18555785_Chip-Seq_ESCs_Mouse1.07334296
84SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07320978
85CMYC_18555785_Chip-Seq_ESCs_Mouse1.07154300
86FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07124611
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07091088
88NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06616157
89EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06053676
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05954500
91CDX2_22108803_ChIP-Seq_LS180_Human1.05163692
92FOXA1_25329375_ChIP-Seq_VCAP_Human1.04732430
93FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04732430
94OCT4_21477851_ChIP-Seq_ESCs_Mouse1.04579214
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04194099
96AR_20517297_ChIP-Seq_VCAP_Human1.03707224
97E2F4_17652178_ChIP-ChIP_JURKAT_Human1.03522611
98CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.02412733
99FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00611690
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00609701

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation3.50869344
2MP0003136_yellow_coat_color2.91412405
3MP0002102_abnormal_ear_morphology2.79913507
4MP0003880_abnormal_central_pattern2.73799216
5MP0008877_abnormal_DNA_methylation2.66739800
6MP0000569_abnormal_digit_pigmentation2.61062543
7MP0002736_abnormal_nociception_after2.50032138
8MP0006072_abnormal_retinal_apoptosis2.32618631
9MP0003787_abnormal_imprinting2.30953808
10MP0005646_abnormal_pituitary_gland2.22360773
11MP0003011_delayed_dark_adaptation2.03445397
12MP0005551_abnormal_eye_electrophysiolog2.02151988
13MP0005084_abnormal_gallbladder_morpholo2.01302937
14MP0005253_abnormal_eye_physiology1.98199030
15MP0005174_abnormal_tail_pigmentation1.96921106
16MP0005379_endocrine/exocrine_gland_phen1.96223369
17MP0001968_abnormal_touch/_nociception1.93273946
18MP0002837_dystrophic_cardiac_calcinosis1.91463462
19MP0002938_white_spotting1.88195481
20MP0001529_abnormal_vocalization1.77072290
21MP0001984_abnormal_olfaction1.72479023
22MP0002876_abnormal_thyroid_physiology1.71502794
23MP0002163_abnormal_gland_morphology1.69871519
24MP0009046_muscle_twitch1.69304533
25MP0004215_abnormal_myocardial_fiber1.68293813
26MP0006276_abnormal_autonomic_nervous1.67268986
27MP0004142_abnormal_muscle_tone1.65711482
28MP0003195_calcinosis1.61332496
29MP0005075_abnormal_melanosome_morpholog1.54874882
30MP0004147_increased_porphyrin_level1.53811071
31MP0002272_abnormal_nervous_system1.53053896
32MP0009697_abnormal_copulation1.52931806
33MP0006292_abnormal_olfactory_placode1.51150038
34MP0005464_abnormal_platelet_physiology1.48612490
35MP0008872_abnormal_physiological_respon1.46423589
36MP0002234_abnormal_pharynx_morphology1.42372412
37MP0006036_abnormal_mitochondrial_physio1.39130550
38MP0001486_abnormal_startle_reflex1.38881430
39MP0002095_abnormal_skin_pigmentation1.36966997
40MP0008058_abnormal_DNA_repair1.36780110
41MP0003186_abnormal_redox_activity1.35668454
42MP0009745_abnormal_behavioral_response1.35553732
43MP0008789_abnormal_olfactory_epithelium1.34974978
44MP0000631_abnormal_neuroendocrine_gland1.34885585
45MP0002735_abnormal_chemical_nociception1.30796204
46MP0003122_maternal_imprinting1.29563797
47MP0006054_spinal_hemorrhage1.27961678
48MP0003121_genomic_imprinting1.27518594
49MP0003718_maternal_effect1.26041315
50MP0002822_catalepsy1.23926243
51MP0002090_abnormal_vision1.22972904
52MP0001485_abnormal_pinna_reflex1.20992837
53MP0004885_abnormal_endolymph1.18612673
54MP0005171_absent_coat_pigmentation1.14544407
55MP0001905_abnormal_dopamine_level1.14254412
56MP0001970_abnormal_pain_threshold1.14006639
57MP0002733_abnormal_thermal_nociception1.13867730
58MP0005645_abnormal_hypothalamus_physiol1.13151197
59MP0004924_abnormal_behavior1.09876033
60MP0005386_behavior/neurological_phenoty1.09876033
61MP0001986_abnormal_taste_sensitivity1.09573070
62MP0005367_renal/urinary_system_phenotyp1.08656777
63MP0000516_abnormal_urinary_system1.08656777
64MP0008775_abnormal_heart_ventricle1.07032120
65MP0002067_abnormal_sensory_capabilities1.04682305
66MP0002751_abnormal_autonomic_nervous1.04679569
67MP0002909_abnormal_adrenal_gland1.03852337
68MP0002638_abnormal_pupillary_reflex1.03228339
69MP0000015_abnormal_ear_pigmentation1.01444955
70MP0002572_abnormal_emotion/affect_behav1.00108967
71MP0003137_abnormal_impulse_conducting0.98368049
72MP0001324_abnormal_eye_pigmentation0.98356841
73MP0002557_abnormal_social/conspecific_i0.96968122
74MP0000427_abnormal_hair_cycle0.96759943
75MP0000230_abnormal_systemic_arterial0.95914692
76MP0002653_abnormal_ependyma_morphology0.94934052
77MP0009780_abnormal_chondrocyte_physiolo0.94814606
78MP0005394_taste/olfaction_phenotype0.93663589
79MP0005499_abnormal_olfactory_system0.93663589
80MP0005187_abnormal_penis_morphology0.93420003
81MP0001764_abnormal_homeostasis0.92315554
82MP0002064_seizures0.91568875
83MP0004084_abnormal_cardiac_muscle0.91244399
84MP0003283_abnormal_digestive_organ0.87804950
85MP0010094_abnormal_chromosome_stability0.87799969
86MP0010386_abnormal_urinary_bladder0.87522350
87MP0008057_abnormal_DNA_replication0.86978399
88MP0000778_abnormal_nervous_system0.85490527
89MP0004085_abnormal_heartbeat0.84176813
90MP0002734_abnormal_mechanical_nocicepti0.83540354
91MP0003635_abnormal_synaptic_transmissio0.81960444
92MP0006035_abnormal_mitochondrial_morpho0.79774271
93MP0001293_anophthalmia0.78842029
94MP0005195_abnormal_posterior_eye0.77818032
95MP0003567_abnormal_fetal_cardiomyocyte0.77403030
96MP0001756_abnormal_urination0.76130941
97MP0002229_neurodegeneration0.75330126
98MP0001188_hyperpigmentation0.75095133
99MP0000647_abnormal_sebaceous_gland0.74941127
100MP0005332_abnormal_amino_acid0.72691266

Predicted human phenotypes

RankGene SetZ-score
1Medial flaring of the eyebrow (HP:0010747)3.62985040
2Acute necrotizing encephalopathy (HP:0006965)3.55335692
3Pancreatic fibrosis (HP:0100732)3.29685654
4Progressive macrocephaly (HP:0004481)3.24739519
5Pancreatic cysts (HP:0001737)3.17803525
6Abnormality of midbrain morphology (HP:0002418)3.12483436
7Molar tooth sign on MRI (HP:0002419)3.12483436
8Acute encephalopathy (HP:0006846)3.10913129
93-Methylglutaconic aciduria (HP:0003535)3.06336089
10Abnormal mitochondria in muscle tissue (HP:0008316)3.04068766
11Abnormality of the labia minora (HP:0012880)3.03898522
12Mitochondrial inheritance (HP:0001427)3.01042889
13Congenital primary aphakia (HP:0007707)2.98981609
14Nephrogenic diabetes insipidus (HP:0009806)2.97970598
15Gait imbalance (HP:0002141)2.96951650
16Renal cortical cysts (HP:0000803)2.96613036
17Increased CSF lactate (HP:0002490)2.81851732
18True hermaphroditism (HP:0010459)2.80022858
19Hepatic necrosis (HP:0002605)2.72283610
20Nephronophthisis (HP:0000090)2.68092376
21Aplasia/Hypoplasia of the fovea (HP:0008060)2.66852428
22Hypoplasia of the fovea (HP:0007750)2.66852428
23Abnormality of the renal cortex (HP:0011035)2.59462012
24Congenital stationary night blindness (HP:0007642)2.58129277
25Decreased central vision (HP:0007663)2.51920448
26Genital tract atresia (HP:0001827)2.50638092
27Lipid accumulation in hepatocytes (HP:0006561)2.49909217
28Methylmalonic acidemia (HP:0002912)2.49544979
29Hypoglycemic coma (HP:0001325)2.49127075
30Increased hepatocellular lipid droplets (HP:0006565)2.45544657
31Abnormality of lateral ventricle (HP:0030047)2.44433745
32Abolished electroretinogram (ERG) (HP:0000550)2.42787854
33Hypothermia (HP:0002045)2.41852191
34Congenital, generalized hypertrichosis (HP:0004540)2.38964301
35Hepatocellular necrosis (HP:0001404)2.36528931
36Vaginal atresia (HP:0000148)2.35924555
37Optic nerve hypoplasia (HP:0000609)2.33116109
38Volvulus (HP:0002580)2.33013670
39Abnormality of the renal medulla (HP:0100957)2.30906724
40Abnormality of the fovea (HP:0000493)2.29524928
41Gaze-evoked nystagmus (HP:0000640)2.28279013
42Petechiae (HP:0000967)2.24339418
43Cerebral edema (HP:0002181)2.18622452
44Renal Fanconi syndrome (HP:0001994)2.17525473
45Hemiparesis (HP:0001269)2.15558240
46Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.14306047
47Ketoacidosis (HP:0001993)2.11750596
48Hyperinsulinemic hypoglycemia (HP:0000825)2.07038800
49Febrile seizures (HP:0002373)2.05671168
50Poor coordination (HP:0002370)2.02657151
51Hyperglycinemia (HP:0002154)2.01860739
52Abnormality of the pancreatic islet cells (HP:0006476)2.01817622
53Abnormality of endocrine pancreas physiology (HP:0012093)2.01817622
54Prolonged bleeding time (HP:0003010)2.00959545
55Intestinal atresia (HP:0011100)1.99765913
56Optic disc pallor (HP:0000543)1.95607118
57Hypomagnesemia (HP:0002917)1.94879382
58Lissencephaly (HP:0001339)1.92590664
59Sclerocornea (HP:0000647)1.91928456
60Type II lissencephaly (HP:0007260)1.89791818
61Broad-based gait (HP:0002136)1.89756106
62Postaxial hand polydactyly (HP:0001162)1.89564841
63Pachygyria (HP:0001302)1.88954690
64Methylmalonic aciduria (HP:0012120)1.87579595
65Decreased electroretinogram (ERG) amplitude (HP:0000654)1.87109255
66Congenital hepatic fibrosis (HP:0002612)1.86133403
67Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85631638
68Abnormality of alanine metabolism (HP:0010916)1.85631638
69Hyperalaninemia (HP:0003348)1.85631638
70Pancreatic islet-cell hyperplasia (HP:0004510)1.85017117
71Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.84948681
72Decreased activity of mitochondrial respiratory chain (HP:0008972)1.83867334
73Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.83867334
74Generalized aminoaciduria (HP:0002909)1.83734878
75Increased mean platelet volume (HP:0011877)1.83710042
76Dyschromatopsia (HP:0007641)1.83556492
77Hyperlipoproteinemia (HP:0010980)1.83095673
78Male pseudohermaphroditism (HP:0000037)1.81557393
79Aplasia/Hypoplasia of the tongue (HP:0010295)1.80741805
80Specific learning disability (HP:0001328)1.77025581
81Hyperventilation (HP:0002883)1.76939805
82Increased serum lactate (HP:0002151)1.75866906
83Attenuation of retinal blood vessels (HP:0007843)1.74491977
84Septo-optic dysplasia (HP:0100842)1.74201198
85Abnormality of aspartate family amino acid metabolism (HP:0010899)1.73667156
86Aplasia/Hypoplasia of the macula (HP:0008059)1.73356782
87Inability to walk (HP:0002540)1.72899115
88Lactic acidosis (HP:0003128)1.72303967
89Median cleft lip (HP:0000161)1.72135932
90Colon cancer (HP:0003003)1.70651882
91Glycosuria (HP:0003076)1.69488874
92Abnormality of urine glucose concentration (HP:0011016)1.69488874
93Exertional dyspnea (HP:0002875)1.69258815
94Polyphagia (HP:0002591)1.68721559
95Hypoglycemic seizures (HP:0002173)1.68704427
96Broad foot (HP:0001769)1.66941220
97Leukodystrophy (HP:0002415)1.66663310
98Absent speech (HP:0001344)1.66427795
99X-linked dominant inheritance (HP:0001423)1.66127384
100Respiratory failure (HP:0002878)1.65924033

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.71004230
2FRK3.57927449
3BMPR1B3.24694787
4MAP4K23.15502557
5PINK12.91077820
6WNK32.31974082
7BCR2.18000305
8PNCK2.11452172
9NUAK12.11214987
10MST42.04000723
11CASK1.93394271
12ACVR1B1.79339376
13MAPK131.77435576
14ADRBK21.70361339
15TNIK1.70317902
16PLK21.66465252
17ERBB31.62584054
18STK38L1.62039177
19MAP3K41.59811578
20ZAK1.59500047
21GRK11.51336172
22EIF2AK11.48320236
23WEE11.46763351
24STK161.45075301
25EIF2AK31.40063542
26PLK31.36093285
27MKNK21.35840631
28MARK11.34785541
29CSNK1G11.32745887
30MAP3K121.29341951
31BCKDK1.29041440
32PAK31.28565309
33CSNK1G31.27456456
34CSNK1G21.23313893
35STK31.20613570
36DYRK21.13301476
37MYLK1.09637288
38VRK11.06575023
39MAP2K71.06443778
40GRK50.92315869
41CSNK1A1L0.90932176
42PRKCG0.90797776
43BUB10.89391638
44TEC0.89034616
45MKNK10.87930276
46PTK2B0.87180112
47INSRR0.81272624
48PRKCE0.79587680
49VRK20.77378169
50WNK40.76080148
51TAOK30.75565999
52TGFBR10.74431250
53STK390.74100162
54CAMKK20.70155599
55MINK10.65777782
56SRPK10.64847622
57ADRBK10.64709022
58NEK10.63502627
59FER0.63105248
60PKN10.61395411
61DAPK20.61267470
62TLK10.58739688
63CAMK2A0.57234454
64OBSCN0.56835183
65BRSK20.56737159
66OXSR10.56256301
67CCNB10.56066825
68MAPKAPK30.50831921
69PLK40.50689528
70PHKG20.50320191
71PHKG10.50320191
72EPHA40.50026203
73TSSK60.49611178
74TXK0.49356807
75TNK20.49234479
76PLK10.47775675
77TAF10.47373894
78CSNK1A10.43769966
79ROCK10.42323036
80PRKACA0.40897260
81LIMK10.39521132
82DYRK1A0.39432231
83EIF2AK20.37992322
84DAPK10.37348581
85CSNK1D0.36535765
86ATM0.35325082
87EPHB20.34871091
88CDK80.34688528
89STK240.34664651
90CDK30.34613612
91CAMK2D0.34506676
92PRKACB0.34100464
93PRKG10.34082760
94CDC70.32814067
95FLT30.32164496
96NTRK30.31537612
97PRKCQ0.30286570
98ATR0.30250571
99DYRK30.29575952
100PRKCA0.28576742

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.87901716
2Oxidative phosphorylation_Homo sapiens_hsa001903.12920023
3Parkinsons disease_Homo sapiens_hsa050122.65366802
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.57723728
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.43867879
6Non-homologous end-joining_Homo sapiens_hsa034502.21551777
7Propanoate metabolism_Homo sapiens_hsa006402.11449511
8Butanoate metabolism_Homo sapiens_hsa006502.04654755
9Proteasome_Homo sapiens_hsa030502.04194048
10Homologous recombination_Homo sapiens_hsa034402.03392322
11Nitrogen metabolism_Homo sapiens_hsa009102.03207390
12Phototransduction_Homo sapiens_hsa047441.98821757
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.97048698
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.95283877
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.94661304
16Fatty acid elongation_Homo sapiens_hsa000621.79683169
17Fanconi anemia pathway_Homo sapiens_hsa034601.74441864
18Basal transcription factors_Homo sapiens_hsa030221.74163855
19Collecting duct acid secretion_Homo sapiens_hsa049661.71898195
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.70201079
21Huntingtons disease_Homo sapiens_hsa050161.61547818
22RNA polymerase_Homo sapiens_hsa030201.58397204
23Alzheimers disease_Homo sapiens_hsa050101.56981134
24Nicotine addiction_Homo sapiens_hsa050331.56738262
25Regulation of autophagy_Homo sapiens_hsa041401.50723151
26Steroid biosynthesis_Homo sapiens_hsa001001.42706781
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.40471498
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.39378957
29Mismatch repair_Homo sapiens_hsa034301.33293057
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23790470
31Tryptophan metabolism_Homo sapiens_hsa003801.21685113
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.19570611
33Peroxisome_Homo sapiens_hsa041461.19533820
34Caffeine metabolism_Homo sapiens_hsa002321.19495280
35Linoleic acid metabolism_Homo sapiens_hsa005911.17740660
36RNA degradation_Homo sapiens_hsa030181.15316129
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15092612
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12210300
39beta-Alanine metabolism_Homo sapiens_hsa004101.12123762
40Morphine addiction_Homo sapiens_hsa050321.08246721
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.06442624
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.06146843
43GABAergic synapse_Homo sapiens_hsa047271.02496322
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01796940
45Cardiac muscle contraction_Homo sapiens_hsa042601.01353734
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.00609515
47Purine metabolism_Homo sapiens_hsa002301.00305218
48Circadian entrainment_Homo sapiens_hsa047130.99493897
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95235497
50Serotonergic synapse_Homo sapiens_hsa047260.94083440
51Taste transduction_Homo sapiens_hsa047420.94010775
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.89350606
53Sulfur metabolism_Homo sapiens_hsa009200.88053603
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87948033
55Glutathione metabolism_Homo sapiens_hsa004800.86768289
56Nucleotide excision repair_Homo sapiens_hsa034200.85976262
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85930668
58Fatty acid metabolism_Homo sapiens_hsa012120.85799575
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85219705
60One carbon pool by folate_Homo sapiens_hsa006700.82477404
61Chemical carcinogenesis_Homo sapiens_hsa052040.82449641
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.81001405
63Olfactory transduction_Homo sapiens_hsa047400.78800793
64Fatty acid degradation_Homo sapiens_hsa000710.78208490
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77923391
66Ether lipid metabolism_Homo sapiens_hsa005650.76804597
67Arachidonic acid metabolism_Homo sapiens_hsa005900.75407653
68Retinol metabolism_Homo sapiens_hsa008300.73472069
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72137284
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68966611
71Glutamatergic synapse_Homo sapiens_hsa047240.67698193
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.66896802
73Metabolic pathways_Homo sapiens_hsa011000.66200598
74Dopaminergic synapse_Homo sapiens_hsa047280.65659225
75Synaptic vesicle cycle_Homo sapiens_hsa047210.65156231
76Insulin secretion_Homo sapiens_hsa049110.64296824
77Pyruvate metabolism_Homo sapiens_hsa006200.64251376
78Circadian rhythm_Homo sapiens_hsa047100.62664102
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59834275
80Pyrimidine metabolism_Homo sapiens_hsa002400.58649639
81Oocyte meiosis_Homo sapiens_hsa041140.55384022
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53804079
83Glycerolipid metabolism_Homo sapiens_hsa005610.52880439
84Amphetamine addiction_Homo sapiens_hsa050310.52732477
85Folate biosynthesis_Homo sapiens_hsa007900.51057639
86Platelet activation_Homo sapiens_hsa046110.49223887
87Long-term depression_Homo sapiens_hsa047300.48389628
88RNA transport_Homo sapiens_hsa030130.46720120
89Salivary secretion_Homo sapiens_hsa049700.45818326
90Type I diabetes mellitus_Homo sapiens_hsa049400.44786128
91Renin secretion_Homo sapiens_hsa049240.43358152
92Selenocompound metabolism_Homo sapiens_hsa004500.43056337
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41487718
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41202114
95Hedgehog signaling pathway_Homo sapiens_hsa043400.40634547
96Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.36517364
97Arginine and proline metabolism_Homo sapiens_hsa003300.35033811
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34060709
99Alcoholism_Homo sapiens_hsa050340.33747125
100DNA replication_Homo sapiens_hsa030300.32097121

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