ZNF266

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing many tandem zinc-finger motifs. Zinc fingers are protein or nucleic acid-binding domains, and may be involved in a variety of functions, including regulation of transcription. This gene is located in a cluster of similar genes encoding zinc finger proteins on chromosome 19. Alternative splicing results in multiple transcript variants for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to interleukin-15 (GO:0071350)5.25864882
2positive regulation of gamma-delta T cell activation (GO:0046645)5.21431576
3regulation of B cell receptor signaling pathway (GO:0050855)4.81048034
4response to interleukin-15 (GO:0070672)4.79249329
5positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.77871802
6negative T cell selection (GO:0043383)4.51072439
7negative thymic T cell selection (GO:0045060)4.49530411
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.16090668
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.15629135
10negative regulation of cell killing (GO:0031342)4.15629135
11histone H2A acetylation (GO:0043968)4.14705890
12cell wall macromolecule catabolic process (GO:0016998)4.12283987
13activated T cell proliferation (GO:0050798)3.88310222
14response to pheromone (GO:0019236)3.87345735
15positive regulation of granulocyte differentiation (GO:0030854)3.85181663
16positive regulation of B cell differentiation (GO:0045579)3.83951743
17regulation of gamma-delta T cell differentiation (GO:0045586)3.83625615
18B cell receptor signaling pathway (GO:0050853)3.80880221
19regulation of gamma-delta T cell activation (GO:0046643)3.79806035
20somatic diversification of immune receptors via somatic mutation (GO:0002566)3.76081233
21somatic hypermutation of immunoglobulin genes (GO:0016446)3.76081233
22regulation of B cell differentiation (GO:0045577)3.59939528
23pericardium development (GO:0060039)3.58871361
24male sex determination (GO:0030238)3.56340344
25antigen processing and presentation of endogenous antigen (GO:0019883)3.54728127
26antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.54517088
27cell wall macromolecule metabolic process (GO:0044036)3.50102549
28inositol phosphate catabolic process (GO:0071545)3.46581445
29positive T cell selection (GO:0043368)3.45934001
30T cell migration (GO:0072678)3.44154254
31regulation of alpha-beta T cell proliferation (GO:0046640)3.35501233
32tolerance induction (GO:0002507)3.28849404
33T cell selection (GO:0045058)3.27668656
34regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.26911598
35positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)3.26263708
36intraciliary transport (GO:0042073)3.18018634
37regulation of mast cell activation (GO:0033003)3.17748968
38positive regulation of DNA-templated transcription, initiation (GO:2000144)3.15121530
39antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.14045365
40positive thymic T cell selection (GO:0045059)3.09505355
41negative regulation of mast cell activation (GO:0033004)3.07906789
42regulation of T cell tolerance induction (GO:0002664)3.07085390
43polyol catabolic process (GO:0046174)3.03779633
44regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.01198287
45histone mRNA catabolic process (GO:0071044)3.00628771
46thymic T cell selection (GO:0045061)3.00143733
47antigen receptor-mediated signaling pathway (GO:0050851)2.94695949
48regulation of cellular extravasation (GO:0002691)2.94029687
49mast cell activation (GO:0045576)2.90120996
50regulation of granulocyte differentiation (GO:0030852)2.88848959
51positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.88600798
52negative regulation of alpha-beta T cell activation (GO:0046636)2.88443170
53mast cell activation involved in immune response (GO:0002279)2.86779688
54mast cell degranulation (GO:0043303)2.86779688
55regulation of mast cell activation involved in immune response (GO:0033006)2.86641781
56neural tube formation (GO:0001841)2.86348357
57adaptation of signaling pathway (GO:0023058)2.85887424
58monoubiquitinated protein deubiquitination (GO:0035520)2.81958238
59histone H3-K4 trimethylation (GO:0080182)2.81701012
60positive regulation of developmental pigmentation (GO:0048087)2.80177133
61regulation of tolerance induction (GO:0002643)2.79630626
62positive regulation of tolerance induction (GO:0002645)2.78478963
63regulation of mast cell degranulation (GO:0043304)2.77676201
64regulation of erythrocyte differentiation (GO:0045646)2.76732141
65negative regulation of lymphocyte mediated immunity (GO:0002707)2.76728367
66regulation of timing of cell differentiation (GO:0048505)2.74837250
67peptidyl-lysine trimethylation (GO:0018023)2.74002911
68fucose catabolic process (GO:0019317)2.72271466
69L-fucose metabolic process (GO:0042354)2.72271466
70L-fucose catabolic process (GO:0042355)2.72271466
71regulation of regulatory T cell differentiation (GO:0045589)2.71963234
72positive regulation of alpha-beta T cell proliferation (GO:0046641)2.69988368
73regulation of interleukin-1 beta secretion (GO:0050706)2.68997209
74positive regulation of interleukin-1 beta secretion (GO:0050718)2.68479445
75regulation of T cell receptor signaling pathway (GO:0050856)2.66875859
76defense response to protozoan (GO:0042832)2.64928013
77cellular extravasation (GO:0045123)2.64474109
78B cell homeostasis (GO:0001782)2.63461652
79immunoglobulin mediated immune response (GO:0016064)2.62735340
80negative regulation of leukocyte mediated immunity (GO:0002704)2.62514718
81negative regulation of protein oligomerization (GO:0032460)2.60827421
82positive regulation of mast cell activation (GO:0033005)2.59682600
83regulation of development, heterochronic (GO:0040034)2.58569187
84quinone biosynthetic process (GO:1901663)2.56564469
85positive regulation of defense response to virus by host (GO:0002230)2.56054248
86DNA deamination (GO:0045006)2.55809812
87interferon-gamma production (GO:0032609)2.55170787
88T cell receptor signaling pathway (GO:0050852)2.54972091
89neutrophil activation (GO:0042119)2.54659014
90anterograde synaptic vesicle transport (GO:0048490)2.54643592
91regulation of natural killer cell mediated immunity (GO:0002715)2.53937292
92regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.53937292
93N-terminal protein amino acid acetylation (GO:0006474)2.53180734
94regulation of cilium movement (GO:0003352)2.52915749
95ubiquinone biosynthetic process (GO:0006744)2.52860343
96positive regulation of interleukin-2 production (GO:0032743)2.52792706
97pyrimidine ribonucleoside catabolic process (GO:0046133)2.51197681
98limb development (GO:0060173)2.50225845
99appendage development (GO:0048736)2.50225845
100regulation of antigen processing and presentation (GO:0002577)2.50158661

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.88314744
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.78634668
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.46242348
4* ZNF274_21170338_ChIP-Seq_K562_Hela3.34545341
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.90827830
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.81998829
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.73914697
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.68183329
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.63573628
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.42377098
11MYB_26560356_Chip-Seq_TH2_Human2.34186822
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.29241052
13RUNX_20019798_ChIP-Seq_JUKART_Human2.10319510
14HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.03562494
15GATA3_26560356_Chip-Seq_TH2_Human1.92481671
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.92344845
17FUS_26573619_Chip-Seq_HEK293_Human1.90501946
18NOTCH1_21737748_ChIP-Seq_TLL_Human1.89575766
19POU3F2_20337985_ChIP-ChIP_501MEL_Human1.89274641
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.80547049
21GATA3_27048872_Chip-Seq_THYMUS_Human1.79558330
22VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.76718530
23GATA1_22025678_ChIP-Seq_K562_Human1.75888311
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.74060736
25SMAD_19615063_ChIP-ChIP_OVARY_Human1.70586368
26RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.67405450
27IRF8_27001747_Chip-Seq_BMDM_Mouse1.66717019
28TAF15_26573619_Chip-Seq_HEK293_Human1.66529045
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.65315702
30EWS_26573619_Chip-Seq_HEK293_Human1.60679813
31MYB_26560356_Chip-Seq_TH1_Human1.57922342
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.54641432
33VDR_23849224_ChIP-Seq_CD4+_Human1.51611539
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51148960
35SPI1_23547873_ChIP-Seq_NB4_Human1.50134008
36IRF1_19129219_ChIP-ChIP_H3396_Human1.48792334
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43242463
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.43228275
39* VDR_22108803_ChIP-Seq_LS180_Human1.37921143
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37584233
41IGF1R_20145208_ChIP-Seq_DFB_Human1.35265283
42EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.34899129
43CIITA_25753668_ChIP-Seq_RAJI_Human1.30549086
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30265770
45SCL_19346495_ChIP-Seq_HPC-7_Human1.28533534
46P300_19829295_ChIP-Seq_ESCs_Human1.26721235
47ER_23166858_ChIP-Seq_MCF-7_Human1.24892691
48TP53_16413492_ChIP-PET_HCT116_Human1.24766946
49EST1_17652178_ChIP-ChIP_JURKAT_Human1.23186958
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22341968
51TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22068513
52POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22068513
53FOXP3_21729870_ChIP-Seq_TREG_Human1.21944235
54SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20957381
55BCAT_22108803_ChIP-Seq_LS180_Human1.19552675
56NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.19532714
57E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.18147759
58CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17679257
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16248321
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16027495
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.15397956
62CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.14845932
63TCF4_23295773_ChIP-Seq_U87_Human1.14759601
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13702560
65LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13593697
66ETV2_25802403_ChIP-Seq_MESCs_Mouse1.12510965
67E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.12335470
68SMRT_27268052_Chip-Seq_Bcells_Human1.12275903
69PRDM14_20953172_ChIP-Seq_ESCs_Human1.11462766
70TP63_19390658_ChIP-ChIP_HaCaT_Human1.11353781
71RUNX2_22187159_ChIP-Seq_PCA_Human1.09852908
72EZH2_22144423_ChIP-Seq_EOC_Human1.08966135
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07403466
74DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06616767
75FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06453092
76AR_20517297_ChIP-Seq_VCAP_Human1.06125128
77CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.04777272
78VDR_24787735_ChIP-Seq_THP-1_Human1.04311436
79STAT3_23295773_ChIP-Seq_U87_Human1.04097557
80EZH2_27294783_Chip-Seq_NPCs_Mouse1.03273976
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03264281
82TP53_22573176_ChIP-Seq_HFKS_Human1.02710702
83FLI1_21867929_ChIP-Seq_TH2_Mouse1.02398849
84GBX2_23144817_ChIP-Seq_PC3_Human1.01920643
85SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01104364
86GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.00855436
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00499643
88* GABP_17652178_ChIP-ChIP_JURKAT_Human0.99683705
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99442349
90PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98519923
91TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98244043
92CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97837802
93NFE2_27457419_Chip-Seq_LIVER_Mouse0.96586606
94FOXA1_25329375_ChIP-Seq_VCAP_Human0.96359258
95FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96359258
96GATA3_26560356_Chip-Seq_TH1_Human0.96299303
97MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.93565586
98PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93061551
99CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91337379
100CRX_20693478_ChIP-Seq_RETINA_Mouse0.91280105

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis3.91903832
2MP0003763_abnormal_thymus_physiology3.24190408
3MP0001835_abnormal_antigen_presentation3.05059963
4MP0005671_abnormal_response_to2.91935558
5MP0001800_abnormal_humoral_immune2.81569422
6MP0005075_abnormal_melanosome_morpholog2.54094818
7MP0003724_increased_susceptibility_to2.53148083
8MP0008057_abnormal_DNA_replication2.33031695
9MP0003436_decreased_susceptibility_to2.27092561
10MP0005000_abnormal_immune_tolerance2.20585099
11MP0002102_abnormal_ear_morphology2.17364126
12MP0002723_abnormal_immune_serum2.14226413
13MP0000372_irregular_coat_pigmentation2.12578277
14MP0002420_abnormal_adaptive_immunity2.09566514
15MP0005387_immune_system_phenotype2.08078179
16MP0001790_abnormal_immune_system2.08078179
17MP0001819_abnormal_immune_cell2.07402488
18MP0002452_abnormal_antigen_presenting2.04912149
19MP0008877_abnormal_DNA_methylation1.98414206
20MP0002138_abnormal_hepatobiliary_system1.97611537
21MP0000685_abnormal_immune_system1.88380590
22MP0002398_abnormal_bone_marrow1.86066087
23MP0005310_abnormal_salivary_gland1.80726079
24MP0001764_abnormal_homeostasis1.80127391
25MP0001986_abnormal_taste_sensitivity1.78617713
26MP0000716_abnormal_immune_system1.77729765
27MP0002277_abnormal_respiratory_mucosa1.69728830
28MP0002928_abnormal_bile_duct1.69594969
29MP0005025_abnormal_response_to1.69156549
30MP0010155_abnormal_intestine_physiology1.64247865
31MP0009785_altered_susceptibility_to1.63877792
32MP0002653_abnormal_ependyma_morphology1.62820467
33MP0000689_abnormal_spleen_morphology1.62726089
34MP0002419_abnormal_innate_immunity1.60590700
35MP0003567_abnormal_fetal_cardiomyocyte1.58753805
36MP0000703_abnormal_thymus_morphology1.53203482
37MP0003172_abnormal_lysosome_physiology1.52937761
38MP0009333_abnormal_splenocyte_physiolog1.45938904
39MP0002166_altered_tumor_susceptibility1.44753558
40MP0002722_abnormal_immune_system1.41290127
41MP0002148_abnormal_hypersensitivity_rea1.39028889
42MP0002405_respiratory_system_inflammati1.38690061
43MP0004381_abnormal_hair_follicle1.33081695
44MP0003300_gastrointestinal_ulcer1.33019915
45MP0002429_abnormal_blood_cell1.29624346
46MP0001873_stomach_inflammation1.27479696
47MP0003787_abnormal_imprinting1.26158497
48MP0006292_abnormal_olfactory_placode1.24107381
49MP0003303_peritoneal_inflammation1.24043811
50MP0003866_abnormal_defecation1.20707673
51MP0008058_abnormal_DNA_repair1.20115772
52MP0001845_abnormal_inflammatory_respons1.17003876
53MP0002396_abnormal_hematopoietic_system1.15961564
54MP0003121_genomic_imprinting1.12559066
55MP0000383_abnormal_hair_follicle1.09533699
56MP0008789_abnormal_olfactory_epithelium1.05291163
57MP0003693_abnormal_embryo_hatching1.04705078
58MP0003943_abnormal_hepatobiliary_system1.03359483
59MP0003183_abnormal_peptide_metabolism1.01798743
60MP0009115_abnormal_fat_cell0.95098112
61MP0004147_increased_porphyrin_level0.93055143
62MP0000015_abnormal_ear_pigmentation0.92580549
63MP0000427_abnormal_hair_cycle0.92170896
64MP0006082_CNS_inflammation0.92086742
65MP0005397_hematopoietic_system_phenotyp0.92036821
66MP0001545_abnormal_hematopoietic_system0.92036821
67MP0002006_tumorigenesis0.90825293
68MP0002009_preneoplasia0.90050917
69MP0002933_joint_inflammation0.89504386
70MP0008469_abnormal_protein_level0.88525993
71MP0005645_abnormal_hypothalamus_physiol0.88338075
72MP0002163_abnormal_gland_morphology0.88075863
73MP0001533_abnormal_skeleton_physiology0.85240726
74MP0009764_decreased_sensitivity_to0.84705386
75MP0005646_abnormal_pituitary_gland0.83331366
76MP0003195_calcinosis0.83134082
77MP0002693_abnormal_pancreas_physiology0.83043045
78MP0005464_abnormal_platelet_physiology0.82429498
79MP0005499_abnormal_olfactory_system0.82169395
80MP0005394_taste/olfaction_phenotype0.82169395
81MP0002095_abnormal_skin_pigmentation0.81967928
82MP0004885_abnormal_endolymph0.79228412
83MP0005376_homeostasis/metabolism_phenot0.78678189
84MP0003252_abnormal_bile_duct0.78284384
85MP0001501_abnormal_sleep_pattern0.77587287
86MP0000569_abnormal_digit_pigmentation0.76058934
87MP0005379_endocrine/exocrine_gland_phen0.75272076
88MP0005253_abnormal_eye_physiology0.74174678
89MP0005551_abnormal_eye_electrophysiolog0.71660657
90MP0002132_abnormal_respiratory_system0.69952572
91MP0003646_muscle_fatigue0.69866443
92MP0004883_abnormal_blood_vessel0.69627725
93MP0002876_abnormal_thyroid_physiology0.67377778
94MP0010094_abnormal_chromosome_stability0.66595984
95MP0000631_abnormal_neuroendocrine_gland0.64367905
96MP0005334_abnormal_fat_pad0.64171756
97MP0003011_delayed_dark_adaptation0.63555467
98MP0008995_early_reproductive_senescence0.63267416
99MP0002210_abnormal_sex_determination0.63178145
100MP0001486_abnormal_startle_reflex0.63143580

Predicted human phenotypes

RankGene SetZ-score
1Intestinal atresia (HP:0011100)6.86928486
2Severe combined immunodeficiency (HP:0004430)4.00587879
3Chronic hepatic failure (HP:0100626)3.71509611
4Thyroiditis (HP:0100646)3.43420978
5Panhypogammaglobulinemia (HP:0003139)3.33100812
6Subaortic stenosis (HP:0001682)3.17250573
7Abnormality of the left ventricular outflow tract (HP:0011103)3.17250573
8Abnormal delayed hypersensitivity skin test (HP:0002963)3.11676874
9Epidermoid cyst (HP:0200040)3.11007547
10Gastrointestinal atresia (HP:0002589)3.10835457
11Combined immunodeficiency (HP:0005387)3.09517156
12Pancreatic cysts (HP:0001737)3.05677503
13Abnormality of eosinophils (HP:0001879)3.02136945
14Agammaglobulinemia (HP:0004432)3.01630712
15Nephronophthisis (HP:0000090)2.91278827
16Stomatitis (HP:0010280)2.91052468
17Ependymoma (HP:0002888)2.81883334
18Basal cell carcinoma (HP:0002671)2.80885297
19Amaurosis fugax (HP:0100576)2.75655378
20Bile duct proliferation (HP:0001408)2.68399193
21Abnormal biliary tract physiology (HP:0012439)2.68399193
22Agnosia (HP:0010524)2.61637209
23Abnormality of the renal cortex (HP:0011035)2.60727149
24Gastrointestinal infarctions (HP:0005244)2.58244064
25Abnormality of the renal medulla (HP:0100957)2.57651154
26Abnormality of lateral ventricle (HP:0030047)2.53685739
27Recurrent bacterial skin infections (HP:0005406)2.51594187
28Abnormal hair whorl (HP:0010721)2.51545623
29Severe visual impairment (HP:0001141)2.51477910
30Abnormality of B cell number (HP:0010975)2.50993508
31Encephalitis (HP:0002383)2.50640848
32Leukocytosis (HP:0001974)2.47046111
33Oligodactyly (hands) (HP:0001180)2.46902579
34Abnormality of T cell number (HP:0011839)2.46763392
35Eczematoid dermatitis (HP:0000976)2.44440174
36T lymphocytopenia (HP:0005403)2.44280793
37Pancreatic fibrosis (HP:0100732)2.43916728
38Toxemia of pregnancy (HP:0100603)2.38749900
39Absent rod-and cone-mediated responses on ERG (HP:0007688)2.38273233
40Lymphopenia (HP:0001888)2.38267235
41Recurrent fungal infections (HP:0002841)2.37741315
42Abnormality of T cells (HP:0002843)2.35507764
43Molar tooth sign on MRI (HP:0002419)2.33986029
44Abnormality of midbrain morphology (HP:0002418)2.33986029
45Cystic liver disease (HP:0006706)2.33248911
46Growth hormone deficiency (HP:0000824)2.31663777
47Rhabdomyosarcoma (HP:0002859)2.31244012
48Tubulointerstitial nephritis (HP:0001970)2.30015547
49True hermaphroditism (HP:0010459)2.28737843
50Stomach cancer (HP:0012126)2.27072467
51Retrobulbar optic neuritis (HP:0100654)2.26979512
52Optic neuritis (HP:0100653)2.26979512
53Myositis (HP:0100614)2.22840489
54Mesangial abnormality (HP:0001966)2.21039308
55Eosinophilia (HP:0001880)2.20579446
56Elevated erythrocyte sedimentation rate (HP:0003565)2.18320455
57Abolished electroretinogram (ERG) (HP:0000550)2.17583184
58Recurrent abscess formation (HP:0002722)2.16930223
59IgG deficiency (HP:0004315)2.16868661
60Abnormality of the prostate (HP:0008775)2.16827445
61Meningitis (HP:0001287)2.13917343
62Polydipsia (HP:0001959)2.13464804
63Abnormal drinking behavior (HP:0030082)2.13464804
64B lymphocytopenia (HP:0010976)2.13216116
65Abnormal rod and cone electroretinograms (HP:0008323)2.12759785
66Pustule (HP:0200039)2.10014254
67Abnormality of cells of the lymphoid lineage (HP:0012140)2.09720304
68Chin dimple (HP:0010751)2.09450810
69Chest pain (HP:0100749)2.09345194
70Tubulointerstitial abnormality (HP:0001969)2.08705388
71Recurrent viral infections (HP:0004429)2.06967397
72Vasculitis (HP:0002633)2.06616260
73Abnormality of the aortic arch (HP:0012303)2.05100595
74Granulocytopenia (HP:0001913)2.03680216
75Congenital stationary night blindness (HP:0007642)2.02671986
76Recurrent sinusitis (HP:0011108)1.99224690
77Astrocytoma (HP:0009592)1.98241362
78Abnormality of the astrocytes (HP:0100707)1.98241362
79Sleep apnea (HP:0010535)1.97852205
80Recurrent cutaneous fungal infections (HP:0011370)1.96975840
81Chronic mucocutaneous candidiasis (HP:0002728)1.96975840
82Recurrent bronchitis (HP:0002837)1.96753974
83Abnormality of male internal genitalia (HP:0000022)1.96677825
84Oligodactyly (HP:0012165)1.95699614
85Widely spaced teeth (HP:0000687)1.94789101
86Synostosis involving the elbow (HP:0003938)1.94363325
87Humeroradial synostosis (HP:0003041)1.94363325
88Mediastinal lymphadenopathy (HP:0100721)1.93393008
89Chronic otitis media (HP:0000389)1.92463795
90Abnormality of T cell physiology (HP:0011840)1.89594420
91Aqueductal stenosis (HP:0002410)1.88633447
92Neoplasm of the tracheobronchial system (HP:0100552)1.88096106
93Tubular atrophy (HP:0000092)1.85845158
94Hypoplastic iliac wings (HP:0002866)1.83957838
95Cerebellar dysplasia (HP:0007033)1.83859187
96Hyperventilation (HP:0002883)1.83380141
97Chronic diarrhea (HP:0002028)1.82738861
98Orchitis (HP:0100796)1.81498817
99Recurrent skin infections (HP:0001581)1.80740035
100Abnormality of the fingertips (HP:0001211)1.80200508

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK166.44569629
2MAP4K23.78524038
3RIPK43.39662485
4ACVR1B3.19726969
5MAP3K133.10008651
6MAP4K12.92423263
7FRK2.84321632
8BMPR1B2.77962875
9TNK22.31711235
10TXK2.28038574
11TAOK32.16797244
12MAP3K72.13965056
13BMPR21.80574770
14MAP3K141.58969356
15SIK31.54404840
16JAK31.53214539
17TYK21.48288637
18BTK1.46012187
19TEC1.40326613
20SYK1.35268301
21MELK1.32371028
22ITK1.31216826
23MAPK131.30084760
24MARK31.29255766
25PRKCQ1.27757896
26TGFBR11.24434028
27FES1.21689530
28BLK1.19008455
29WNK31.15086407
30HCK1.14301006
31IKBKB1.12436941
32FGR1.10765630
33GRK61.09643080
34ADRBK21.07360091
35IKBKE1.00615094
36NTRK31.00251659
37MAP2K20.96781102
38MAP2K10.95731251
39LYN0.94462083
40IRAK10.94097086
41CSK0.92842428
42CSF1R0.92347982
43CHUK0.91658605
44LCK0.89249488
45NLK0.88992232
46YES10.88521653
47ERBB30.86009552
48KIT0.86001069
49MST40.85718627
50IRAK40.85324869
51ZAP700.85054789
52EPHA30.82587658
53BRD40.79645886
54STK110.74772183
55NUAK10.73488937
56SIK20.72494179
57PINK10.72296507
58WEE10.71293655
59PIM10.70823630
60JAK20.66549510
61JAK10.65321628
62GRK10.61064912
63MAP3K40.59213653
64FGFR20.57862148
65FLT30.57556550
66MATK0.56518534
67RET0.56321351
68PASK0.55372899
69TRIM280.55220671
70SRPK10.54689970
71PRKCZ0.52931404
72AKT30.49617375
73PDK10.49541749
74GRK70.49234745
75VRK10.49165078
76ABL10.49087229
77IGF1R0.47321287
78DYRK1A0.47042451
79PIK3CA0.44429403
80SGK20.44321481
81FGFR30.42104661
82NEK20.38215401
83STK38L0.37822610
84TBK10.37547900
85CAMK40.37461450
86MAPK30.34569700
87KSR10.34387171
88MAP3K50.34276584
89CDK40.34133187
90RPS6KB10.33688752
91PKN20.32739902
92PTK2B0.31843604
93TAOK10.31252154
94MAPK110.31016642
95NEK10.30952689
96PIK3CG0.28083202
97PRKCE0.24710798
98PAK30.23969889
99FYN0.23912832
100BCR0.23898759

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.50534437
2Graft-versus-host disease_Homo sapiens_hsa053322.97223905
3Allograft rejection_Homo sapiens_hsa053302.93012290
4Autoimmune thyroid disease_Homo sapiens_hsa053202.87208459
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.60663636
6Type I diabetes mellitus_Homo sapiens_hsa049402.52417873
7Asthma_Homo sapiens_hsa053102.38247746
8T cell receptor signaling pathway_Homo sapiens_hsa046602.22395263
9B cell receptor signaling pathway_Homo sapiens_hsa046622.02112998
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.01355920
11Staphylococcus aureus infection_Homo sapiens_hsa051501.77651030
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.75484074
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.70146908
14Leishmaniasis_Homo sapiens_hsa051401.65781990
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.63849810
16Antigen processing and presentation_Homo sapiens_hsa046121.53992032
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.48048312
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.46008523
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.43200634
20Measles_Homo sapiens_hsa051621.41286106
21Hematopoietic cell lineage_Homo sapiens_hsa046401.39296723
22Osteoclast differentiation_Homo sapiens_hsa043801.37557335
23Fanconi anemia pathway_Homo sapiens_hsa034601.36448292
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.31644486
25African trypanosomiasis_Homo sapiens_hsa051431.26652832
26Ether lipid metabolism_Homo sapiens_hsa005651.24493072
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.24338804
28Linoleic acid metabolism_Homo sapiens_hsa005911.22704609
29Herpes simplex infection_Homo sapiens_hsa051681.20990620
30Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.20115668
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.15488027
32Toxoplasmosis_Homo sapiens_hsa051451.13279506
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08592167
34Viral myocarditis_Homo sapiens_hsa054161.08537881
35Tuberculosis_Homo sapiens_hsa051521.07071111
36Chemokine signaling pathway_Homo sapiens_hsa040621.06994914
37ABC transporters_Homo sapiens_hsa020101.03311111
38FoxO signaling pathway_Homo sapiens_hsa040681.02806447
39Influenza A_Homo sapiens_hsa051641.00154141
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99914199
41Dorso-ventral axis formation_Homo sapiens_hsa043200.98155231
42Acute myeloid leukemia_Homo sapiens_hsa052210.92993898
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.92577085
44Regulation of autophagy_Homo sapiens_hsa041400.91422357
45Toll-like receptor signaling pathway_Homo sapiens_hsa046200.88900876
46Phototransduction_Homo sapiens_hsa047440.88234953
47Non-homologous end-joining_Homo sapiens_hsa034500.88102060
48RNA degradation_Homo sapiens_hsa030180.83327522
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82373073
50Epstein-Barr virus infection_Homo sapiens_hsa051690.81463148
51TNF signaling pathway_Homo sapiens_hsa046680.80374252
52Inositol phosphate metabolism_Homo sapiens_hsa005620.79603920
53Lysine degradation_Homo sapiens_hsa003100.79459057
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78986950
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76488962
56Hepatitis B_Homo sapiens_hsa051610.75062158
57Rheumatoid arthritis_Homo sapiens_hsa053230.74917658
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73892059
59p53 signaling pathway_Homo sapiens_hsa041150.73076935
60Choline metabolism in cancer_Homo sapiens_hsa052310.68694801
61Butanoate metabolism_Homo sapiens_hsa006500.66901990
62Platelet activation_Homo sapiens_hsa046110.66296008
63Prostate cancer_Homo sapiens_hsa052150.65983401
64Non-small cell lung cancer_Homo sapiens_hsa052230.65944403
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65223161
66RNA polymerase_Homo sapiens_hsa030200.64718920
67Insulin resistance_Homo sapiens_hsa049310.64287326
68Caffeine metabolism_Homo sapiens_hsa002320.63494356
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61682506
70mTOR signaling pathway_Homo sapiens_hsa041500.61261276
71Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60717260
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60367571
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.59873799
74Arachidonic acid metabolism_Homo sapiens_hsa005900.58087016
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57195147
76Colorectal cancer_Homo sapiens_hsa052100.57053343
77Endometrial cancer_Homo sapiens_hsa052130.56982451
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.56599571
79Long-term depression_Homo sapiens_hsa047300.55860777
80Hepatitis C_Homo sapiens_hsa051600.53175311
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52980340
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51129291
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.50896137
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50616113
85Nitrogen metabolism_Homo sapiens_hsa009100.48945965
86Homologous recombination_Homo sapiens_hsa034400.48540795
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.45737411
88Glycerolipid metabolism_Homo sapiens_hsa005610.44435050
89Prolactin signaling pathway_Homo sapiens_hsa049170.42791748
90Type II diabetes mellitus_Homo sapiens_hsa049300.40294250
91Peroxisome_Homo sapiens_hsa041460.38067368
92Tryptophan metabolism_Homo sapiens_hsa003800.34202188
93Ras signaling pathway_Homo sapiens_hsa040140.33207579
94Salivary secretion_Homo sapiens_hsa049700.32803408
95Legionellosis_Homo sapiens_hsa051340.32788469
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32504016
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32366604
98VEGF signaling pathway_Homo sapiens_hsa043700.32291443
99Olfactory transduction_Homo sapiens_hsa047400.31942441
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.30465968

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