ZNF260

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)3.96078204
2DNA double-strand break processing (GO:0000729)3.81728629
3presynaptic membrane assembly (GO:0097105)3.81182217
4response to pheromone (GO:0019236)3.72608070
5nonmotile primary cilium assembly (GO:0035058)3.49188958
6behavioral response to nicotine (GO:0035095)3.45253010
7presynaptic membrane organization (GO:0097090)3.38968907
8neural tube formation (GO:0001841)3.33785987
9intraciliary transport (GO:0042073)3.29566141
10nucleobase catabolic process (GO:0046113)3.20199002
11cilium morphogenesis (GO:0060271)3.11507038
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.10119571
13epithelial cilium movement (GO:0003351)3.05161077
14resolution of meiotic recombination intermediates (GO:0000712)3.00060733
15limb bud formation (GO:0060174)2.99437100
16forebrain neuron differentiation (GO:0021879)2.97279619
17replication fork processing (GO:0031297)2.88895639
18olfactory bulb development (GO:0021772)2.84519015
19neuron cell-cell adhesion (GO:0007158)2.83268634
20head development (GO:0060322)2.80630918
21retinal ganglion cell axon guidance (GO:0031290)2.77109369
22somatic diversification of immune receptors via somatic mutation (GO:0002566)2.75188832
23somatic hypermutation of immunoglobulin genes (GO:0016446)2.75188832
24somite development (GO:0061053)2.75016089
25water-soluble vitamin biosynthetic process (GO:0042364)2.74008344
26calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.70029124
27cholesterol biosynthetic process (GO:0006695)2.68429691
28chromatin remodeling at centromere (GO:0031055)2.67501513
29peptidyl-histidine modification (GO:0018202)2.65983970
30positive regulation of mitochondrial fission (GO:0090141)2.65419704
31regulation of cilium movement (GO:0003352)2.64773403
32appendage development (GO:0048736)2.62929976
33limb development (GO:0060173)2.62929976
34postsynaptic membrane organization (GO:0001941)2.62646729
35cilium organization (GO:0044782)2.61092522
36protein-cofactor linkage (GO:0018065)2.60423455
37L-fucose catabolic process (GO:0042355)2.59853103
38fucose catabolic process (GO:0019317)2.59853103
39L-fucose metabolic process (GO:0042354)2.59853103
40cilium assembly (GO:0042384)2.58754747
41negative regulation of DNA-dependent DNA replication (GO:2000104)2.58380447
42regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.57318869
43regulation of mitotic spindle checkpoint (GO:1903504)2.57318869
44isoprenoid biosynthetic process (GO:0008299)2.57113324
45platelet dense granule organization (GO:0060155)2.55293261
46cullin deneddylation (GO:0010388)2.54915099
47axonal fasciculation (GO:0007413)2.54072603
48regulation of development, heterochronic (GO:0040034)2.52626776
49DNA damage response, detection of DNA damage (GO:0042769)2.50851639
50regulation of translation, ncRNA-mediated (GO:0045974)2.47912520
51negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.47912520
52negative regulation of translation, ncRNA-mediated (GO:0040033)2.47912520
53DNA integration (GO:0015074)2.47313171
54CENP-A containing nucleosome assembly (GO:0034080)2.44063404
55sterol biosynthetic process (GO:0016126)2.43677491
56cell proliferation in forebrain (GO:0021846)2.43138416
57neuronal stem cell maintenance (GO:0097150)2.42628008
58negative regulation of DNA recombination (GO:0045910)2.41896485
59kidney morphogenesis (GO:0060993)2.41577653
60negative regulation of oligodendrocyte differentiation (GO:0048715)2.41241275
61ubiquinone metabolic process (GO:0006743)2.40302348
62regulation of telomere maintenance (GO:0032204)2.40279719
63sympathetic nervous system development (GO:0048485)2.40144989
64cilium movement (GO:0003341)2.39223177
65regulation of hexokinase activity (GO:1903299)2.37423656
66regulation of glucokinase activity (GO:0033131)2.37423656
67negative regulation of transcription regulatory region DNA binding (GO:2000678)2.37027699
68histone H2A acetylation (GO:0043968)2.36832401
69regulation of mesoderm development (GO:2000380)2.34576385
70tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.33815343
71RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.33815343
72recombinational repair (GO:0000725)2.33489482
73C4-dicarboxylate transport (GO:0015740)2.32249208
74gamma-aminobutyric acid transport (GO:0015812)2.30426110
75photoreceptor cell maintenance (GO:0045494)2.29698645
76detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.29692196
77double-strand break repair via homologous recombination (GO:0000724)2.29290481
78nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.28405986
79smoothened signaling pathway (GO:0007224)2.28153968
80protein deneddylation (GO:0000338)2.28082869
81mechanosensory behavior (GO:0007638)2.28035549
82protein localization to cilium (GO:0061512)2.26848813
83kinetochore organization (GO:0051383)2.24283457
84regulation of timing of cell differentiation (GO:0048505)2.22527036
85auditory behavior (GO:0031223)2.22247291
86cellular response to cholesterol (GO:0071397)2.22074027
87protein polyglutamylation (GO:0018095)2.21764739
88negative regulation of telomere maintenance (GO:0032205)2.20798056
89reciprocal DNA recombination (GO:0035825)2.20322675
90reciprocal meiotic recombination (GO:0007131)2.20322675
91cellular response to sterol (GO:0036315)2.20249146
92regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.20046849
93G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.19525004
94histone exchange (GO:0043486)2.18965533
95regulation of hippo signaling (GO:0035330)2.18615816
96exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.18494619
97microtubule anchoring (GO:0034453)2.18293755
98preassembly of GPI anchor in ER membrane (GO:0016254)2.17687099
99ganglion development (GO:0061548)2.17306178
100RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.16929202

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.41155580
2IGF1R_20145208_ChIP-Seq_DFB_Human2.88041961
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.85963800
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.78073336
5GBX2_23144817_ChIP-Seq_PC3_Human2.66933357
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.64799725
7FUS_26573619_Chip-Seq_HEK293_Human2.59359792
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.50345478
9EWS_26573619_Chip-Seq_HEK293_Human2.46577188
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.45090860
11VDR_22108803_ChIP-Seq_LS180_Human2.36688663
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.28837068
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.22631260
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.21386565
15TAF15_26573619_Chip-Seq_HEK293_Human2.16523336
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.10044801
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.08950082
18P300_19829295_ChIP-Seq_ESCs_Human2.07266559
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.05290279
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05241856
21ELK1_19687146_ChIP-ChIP_HELA_Human2.01917208
22EST1_17652178_ChIP-ChIP_JURKAT_Human1.98957457
23POU5F1_16153702_ChIP-ChIP_HESCs_Human1.92373244
24EZH2_22144423_ChIP-Seq_EOC_Human1.86377789
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.84723757
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.83035239
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77152430
28IRF1_19129219_ChIP-ChIP_H3396_Human1.76452159
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73793321
30MYC_18940864_ChIP-ChIP_HL60_Human1.66205295
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65932415
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.65611716
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.65021702
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.57003037
35MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51664397
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51546028
37SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50989399
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.50301823
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48887988
40ER_23166858_ChIP-Seq_MCF-7_Human1.48235284
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44973822
42* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44760995
43SMAD4_21799915_ChIP-Seq_A2780_Human1.43416091
44OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42440933
45SOX2_16153702_ChIP-ChIP_HESCs_Human1.40520613
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39726010
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36262209
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35217602
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34370415
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.34231223
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.33670785
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32738064
53CBP_20019798_ChIP-Seq_JUKART_Human1.32738064
54* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32242536
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.31873506
56RNF2_27304074_Chip-Seq_NSC_Mouse1.31142908
57TP63_19390658_ChIP-ChIP_HaCaT_Human1.30437262
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30183806
59STAT3_23295773_ChIP-Seq_U87_Human1.29250509
60CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.25951088
61* VDR_23849224_ChIP-Seq_CD4+_Human1.25929613
62CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.25871271
63RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21603130
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20818482
65KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20307925
66* ETS1_20019798_ChIP-Seq_JURKAT_Human1.17332422
67NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16652776
68NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.15964475
69AR_25329375_ChIP-Seq_VCAP_Human1.14739223
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14634773
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14634773
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13728800
73GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13587307
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.13576164
75TCF4_23295773_ChIP-Seq_U87_Human1.13418684
76FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12465370
77CREB1_15753290_ChIP-ChIP_HEK293T_Human1.12456078
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.12294570
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10719942
80RUNX2_22187159_ChIP-Seq_PCA_Human1.09954032
81* NOTCH1_21737748_ChIP-Seq_TLL_Human1.09178399
82BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08277664
83NANOG_16153702_ChIP-ChIP_HESCs_Human1.07354812
84TCF4_22108803_ChIP-Seq_LS180_Human1.07075933
85BCAT_22108803_ChIP-Seq_LS180_Human1.06946641
86YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06520500
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06321742
88TP53_22573176_ChIP-Seq_HFKS_Human1.06121458
89KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05650873
90SOX2_19829295_ChIP-Seq_ESCs_Human1.02252952
91NANOG_19829295_ChIP-Seq_ESCs_Human1.02252952
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01847968
93FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01721304
94NFE2_27457419_Chip-Seq_LIVER_Mouse1.01718802
95TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99984961
96TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98977731
97JUN_21703547_ChIP-Seq_K562_Human0.98116583
98TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98053691
99P53_22387025_ChIP-Seq_ESCs_Mouse0.97058845
100FOXP3_21729870_ChIP-Seq_TREG_Human0.95321582

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color2.51459343
2MP0006072_abnormal_retinal_apoptosis2.44097429
3MP0008877_abnormal_DNA_methylation2.42614253
4MP0006292_abnormal_olfactory_placode2.34252799
5MP0003890_abnormal_embryonic-extraembry2.29263706
6MP0004133_heterotaxia2.28354316
7MP0001529_abnormal_vocalization2.23540368
8MP0002102_abnormal_ear_morphology2.21331024
9MP0002938_white_spotting2.13882176
10MP0003122_maternal_imprinting2.08654422
11MP0008789_abnormal_olfactory_epithelium2.07287118
12MP0001293_anophthalmia2.04980973
13MP0001984_abnormal_olfaction2.00896179
14MP0003121_genomic_imprinting1.88966600
15MP0002751_abnormal_autonomic_nervous1.87307915
16MP0005394_taste/olfaction_phenotype1.86224629
17MP0005499_abnormal_olfactory_system1.86224629
18MP0003937_abnormal_limbs/digits/tail_de1.85380847
19MP0000778_abnormal_nervous_system1.83898587
20MP0005253_abnormal_eye_physiology1.77961144
21MP0003787_abnormal_imprinting1.75646893
22MP0003880_abnormal_central_pattern1.75390362
23MP0008058_abnormal_DNA_repair1.71934591
24MP0002653_abnormal_ependyma_morphology1.65992575
25MP0002736_abnormal_nociception_after1.57542310
26MP0006276_abnormal_autonomic_nervous1.57220182
27MP0000631_abnormal_neuroendocrine_gland1.49465016
28MP0002233_abnormal_nose_morphology1.47865359
29MP0005171_absent_coat_pigmentation1.47777533
30MP0003119_abnormal_digestive_system1.47648933
31MP0009697_abnormal_copulation1.46550388
32MP0002638_abnormal_pupillary_reflex1.45265079
33MP0005551_abnormal_eye_electrophysiolog1.42402039
34MP0005187_abnormal_penis_morphology1.41239546
35MP0000049_abnormal_middle_ear1.39670871
36MP0000647_abnormal_sebaceous_gland1.33396910
37MP0010094_abnormal_chromosome_stability1.32423047
38MP0001968_abnormal_touch/_nociception1.31555049
39MP0003567_abnormal_fetal_cardiomyocyte1.29204118
40MP0000427_abnormal_hair_cycle1.28682434
41MP0000569_abnormal_digit_pigmentation1.28347846
42MP0008057_abnormal_DNA_replication1.27993030
43MP0005248_abnormal_Harderian_gland1.27634901
44MP0005391_vision/eye_phenotype1.24933843
45MP0001286_abnormal_eye_development1.24858631
46MP0001486_abnormal_startle_reflex1.23841662
47MP0000383_abnormal_hair_follicle1.21341836
48MP0003011_delayed_dark_adaptation1.17597083
49MP0002184_abnormal_innervation1.15843323
50MP0009046_muscle_twitch1.15683776
51MP0000372_irregular_coat_pigmentation1.14092978
52MP0004142_abnormal_muscle_tone1.13815447
53MP0008932_abnormal_embryonic_tissue1.13803812
54MP0003755_abnormal_palate_morphology1.13629001
55MP0002095_abnormal_skin_pigmentation1.12912506
56MP0001485_abnormal_pinna_reflex1.11440508
57MP0000566_synostosis1.10045114
58MP0000955_abnormal_spinal_cord1.09369895
59MP0002697_abnormal_eye_size1.07530664
60MP0001299_abnormal_eye_distance/1.07053788
61MP0002234_abnormal_pharynx_morphology1.04852320
62MP0003861_abnormal_nervous_system1.04655734
63MP0002272_abnormal_nervous_system1.04585928
64MP0002557_abnormal_social/conspecific_i1.04394475
65MP0005195_abnormal_posterior_eye1.03853143
66MP0005645_abnormal_hypothalamus_physiol1.02956903
67MP0002752_abnormal_somatic_nervous1.02849244
68MP0004885_abnormal_endolymph1.01912394
69MP0003938_abnormal_ear_development1.01729682
70MP0000516_abnormal_urinary_system1.00976287
71MP0005367_renal/urinary_system_phenotyp1.00976287
72MP0002084_abnormal_developmental_patter1.00581898
73MP0002928_abnormal_bile_duct1.00180769
74MP0001188_hyperpigmentation0.99262526
75MP0003693_abnormal_embryo_hatching0.99230222
76MP0002837_dystrophic_cardiac_calcinosis0.98287334
77MP0002822_catalepsy0.94246650
78MP0005646_abnormal_pituitary_gland0.90653944
79MP0003195_calcinosis0.90609820
80MP0003718_maternal_effect0.90472281
81MP0002090_abnormal_vision0.89194514
82MP0002572_abnormal_emotion/affect_behav0.88885868
83MP0010030_abnormal_orbit_morphology0.88772062
84MP0003385_abnormal_body_wall0.87584415
85MP0009745_abnormal_behavioral_response0.87217310
86MP0001324_abnormal_eye_pigmentation0.87020877
87MP0002735_abnormal_chemical_nociception0.86986039
88MP0000026_abnormal_inner_ear0.86282834
89MP0002876_abnormal_thyroid_physiology0.83565268
90MP0002152_abnormal_brain_morphology0.82877870
91MP0001177_atelectasis0.81992603
92MP0003283_abnormal_digestive_organ0.81679440
93MP0002111_abnormal_tail_morphology0.80515289
94MP0003935_abnormal_craniofacial_develop0.79820399
95MP0004197_abnormal_fetal_growth/weight/0.78587993
96MP0005386_behavior/neurological_phenoty0.78480721
97MP0004924_abnormal_behavior0.78480721
98MP0002882_abnormal_neuron_morphology0.78216208
99MP0004215_abnormal_myocardial_fiber0.78128529
100MP0002092_abnormal_eye_morphology0.76831736

Predicted human phenotypes

RankGene SetZ-score
1True hermaphroditism (HP:0010459)3.84838371
2Pancreatic fibrosis (HP:0100732)3.82988695
3Pancreatic cysts (HP:0001737)3.65021706
4Colon cancer (HP:0003003)3.27272150
5Molar tooth sign on MRI (HP:0002419)3.18267224
6Abnormality of midbrain morphology (HP:0002418)3.18267224
7Medial flaring of the eyebrow (HP:0010747)3.12590430
8Nephronophthisis (HP:0000090)2.94759465
9Abnormality of the labia minora (HP:0012880)2.93450584
10Gait imbalance (HP:0002141)2.89039199
11Congenital primary aphakia (HP:0007707)2.87610259
12Intestinal atresia (HP:0011100)2.84483594
13Chronic hepatic failure (HP:0100626)2.69746320
14Genital tract atresia (HP:0001827)2.67971498
15Septo-optic dysplasia (HP:0100842)2.66689424
16Nephrogenic diabetes insipidus (HP:0009806)2.65941418
17Vaginal atresia (HP:0000148)2.64710566
18Abnormality of the renal medulla (HP:0100957)2.62236343
19Optic nerve hypoplasia (HP:0000609)2.49159095
20Hepatoblastoma (HP:0002884)2.37158176
21Sclerocornea (HP:0000647)2.36912128
22Hyperglycinemia (HP:0002154)2.33476098
23Supernumerary spleens (HP:0009799)2.33341798
24Cystic liver disease (HP:0006706)2.32676196
25Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.30437512
26Aplasia/Hypoplasia of the tibia (HP:0005772)2.28346464
27Aplasia/Hypoplasia of the tongue (HP:0010295)2.26329960
28Anophthalmia (HP:0000528)2.26028013
29Postaxial foot polydactyly (HP:0001830)2.25549429
30Postaxial hand polydactyly (HP:0001162)2.24566777
31Anencephaly (HP:0002323)2.22012554
32Oligodactyly (hands) (HP:0001180)2.18449857
33Poor coordination (HP:0002370)2.15922477
34Preaxial hand polydactyly (HP:0001177)2.15877351
35Drooling (HP:0002307)2.15368309
36Short tibia (HP:0005736)2.13868727
37Gastrointestinal atresia (HP:0002589)2.12172828
38Pendular nystagmus (HP:0012043)2.11357312
39Bile duct proliferation (HP:0001408)2.10525201
40Abnormal biliary tract physiology (HP:0012439)2.10525201
41Volvulus (HP:0002580)2.09445387
42Abolished electroretinogram (ERG) (HP:0000550)2.06023366
43Bifid tongue (HP:0010297)2.03973761
44Abnormality of the renal cortex (HP:0011035)2.03646119
45Occipital encephalocele (HP:0002085)2.02319848
46Methylmalonic acidemia (HP:0002912)2.01896561
47Broad foot (HP:0001769)1.98634391
48Lissencephaly (HP:0001339)1.97889250
49Cerebellar dysplasia (HP:0007033)1.97032999
50Dandy-Walker malformation (HP:0001305)1.96192123
51Type II lissencephaly (HP:0007260)1.94285366
52Specific learning disability (HP:0001328)1.94277572
53Renal cortical cysts (HP:0000803)1.91881755
54Congenital hepatic fibrosis (HP:0002612)1.89310321
55Renal hypoplasia (HP:0000089)1.88996960
56Excessive salivation (HP:0003781)1.85867384
57Abnormality of the ileum (HP:0001549)1.85807609
58Male pseudohermaphroditism (HP:0000037)1.83332290
59Aplasia/Hypoplasia of the uvula (HP:0010293)1.81968604
60Abnormal lung lobation (HP:0002101)1.81930572
61Narrow forehead (HP:0000341)1.81518141
62Retinal dysplasia (HP:0007973)1.81101304
63Progressive inability to walk (HP:0002505)1.80864441
64Meckel diverticulum (HP:0002245)1.80105433
65Hyperalaninemia (HP:0003348)1.79722471
66Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79722471
67Abnormality of alanine metabolism (HP:0010916)1.79722471
68Thyroid-stimulating hormone excess (HP:0002925)1.75544462
69Stenosis of the external auditory canal (HP:0000402)1.74635391
70Micropenis (HP:0000054)1.72733677
71Glioma (HP:0009733)1.72102968
72Neoplasm of the adrenal cortex (HP:0100641)1.71107218
73Oligodactyly (HP:0012165)1.70494587
74Abnormality of glycine metabolism (HP:0010895)1.69761474
75Abnormality of serine family amino acid metabolism (HP:0010894)1.69761474
76Chorioretinal atrophy (HP:0000533)1.69653095
77Decreased testicular size (HP:0008734)1.69235166
78Hyperventilation (HP:0002883)1.68870089
79Hyperglycinuria (HP:0003108)1.68327745
80Rib fusion (HP:0000902)1.68014043
81Labial hypoplasia (HP:0000066)1.67897072
82Esophageal atresia (HP:0002032)1.67399557
83Aganglionic megacolon (HP:0002251)1.67118572
84Inability to walk (HP:0002540)1.67073405
85Bilateral microphthalmos (HP:0007633)1.66275791
86Astigmatism (HP:0000483)1.65662382
87Absent septum pellucidum (HP:0001331)1.64057777
88Multicystic kidney dysplasia (HP:0000003)1.63691304
89Aqueductal stenosis (HP:0002410)1.63636016
90Tubular atrophy (HP:0000092)1.63558429
91Rhabdomyosarcoma (HP:0002859)1.63019879
92Cutaneous finger syndactyly (HP:0010554)1.62323535
93Abnormality of serum amino acid levels (HP:0003112)1.61982251
94Aplasia/Hypoplasia of the spleen (HP:0010451)1.61702594
95Broad-based gait (HP:0002136)1.60373442
96Sloping forehead (HP:0000340)1.59682145
97Patellar aplasia (HP:0006443)1.59511497
98Pachygyria (HP:0001302)1.58227512
99Keratoconus (HP:0000563)1.58143923
100Increased corneal curvature (HP:0100692)1.58143923

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK33.31611606
2FRK3.15700327
3CASK2.92738111
4MAP3K42.54347192
5TRIM282.53387248
6BMPR1B2.47391151
7BCR2.33410058
8MAP4K22.15884355
9NUAK12.09018368
10MKNK22.05554534
11MAP2K71.97449357
12SRPK11.91662741
13MKNK11.89422541
14ERBB31.82548031
15ZAK1.76334381
16CSNK1G11.66911680
17DYRK21.65499427
18PINK11.61158267
19TNIK1.57323983
20ACVR1B1.56000568
21EPHA41.54744751
22EPHA31.53155367
23CSNK1G21.53023561
24CSNK1G31.49395969
25PNCK1.47096904
26ADRBK21.44717231
27PLK31.43984848
28STK38L1.43427879
29CSNK1A1L1.40590517
30MARK11.39547738
31FGFR21.34725841
32PLK21.28175116
33DYRK31.27811998
34MAPK131.26972023
35CDC71.25975593
36STK391.20827409
37GRK11.19852147
38BCKDK1.15304073
39PBK1.14953144
40TSSK61.14188738
41PAK31.11344000
42WNK41.10397411
43NEK11.07707851
44PRKCE1.01631627
45EIF2AK31.00961762
46VRK10.99280115
47TGFBR10.98117983
48WEE10.97938905
49PLK40.96166380
50OXSR10.95185867
51BRSK20.94021407
52INSRR0.93957861
53NTRK20.91653878
54RPS6KA40.90968978
55PLK10.90683185
56PRKCG0.88503719
57STK30.87011080
58LATS10.82913398
59BUB10.82307421
60BRD40.81507768
61TTK0.80044941
62STK160.78833404
63MINK10.73848341
64ATM0.67939669
65CCNB10.67470487
66ATR0.66767369
67ERBB40.65412513
68TIE10.65378613
69FGFR10.64045192
70FLT30.61868057
71NLK0.61273364
72VRK20.60783880
73AKT30.60291143
74CDK190.58051056
75NEK20.54181667
76CHEK20.50753009
77TAF10.50561248
78EIF2AK10.49199899
79DYRK1A0.48012525
80EPHB20.47188176
81CSNK1A10.46984462
82MAP2K40.46744737
83PASK0.46630418
84AURKB0.44637689
85CSNK1D0.43676429
86RPS6KA50.42821149
87TLK10.42281598
88NTRK30.40459318
89CSNK1E0.40321246
90CAMK2A0.39999668
91KSR10.36479075
92FER0.36452975
93PAK60.35738254
94SGK20.35658339
95EIF2AK20.35266692
96PRKDC0.34116987
97SGK2230.33182357
98SGK4940.33182357
99PRKACB0.33162847
100STK110.30269834

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.32321422
2Steroid biosynthesis_Homo sapiens_hsa001002.91166515
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.88756140
4Protein export_Homo sapiens_hsa030602.78790562
5Non-homologous end-joining_Homo sapiens_hsa034502.52682361
6Butanoate metabolism_Homo sapiens_hsa006502.31889691
7Fanconi anemia pathway_Homo sapiens_hsa034602.19036950
8Propanoate metabolism_Homo sapiens_hsa006402.18185225
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.10693295
10Basal transcription factors_Homo sapiens_hsa030222.06008042
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.96960540
12Homologous recombination_Homo sapiens_hsa034401.94897948
13RNA polymerase_Homo sapiens_hsa030201.94463294
14Phototransduction_Homo sapiens_hsa047441.85592416
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.85437008
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.83691582
17Nicotine addiction_Homo sapiens_hsa050331.79765120
18Selenocompound metabolism_Homo sapiens_hsa004501.78358766
19RNA degradation_Homo sapiens_hsa030181.72040534
20Oxidative phosphorylation_Homo sapiens_hsa001901.57884136
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.55941862
22Mismatch repair_Homo sapiens_hsa034301.54225080
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.49247677
24RNA transport_Homo sapiens_hsa030131.43581116
25Parkinsons disease_Homo sapiens_hsa050121.37881306
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.37145792
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.30038006
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.24788493
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22699725
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21330713
31Peroxisome_Homo sapiens_hsa041461.21223455
32Proteasome_Homo sapiens_hsa030501.20591793
33Caffeine metabolism_Homo sapiens_hsa002321.20167634
34Hedgehog signaling pathway_Homo sapiens_hsa043401.19877091
35Fatty acid elongation_Homo sapiens_hsa000621.19439563
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.18951316
37Nucleotide excision repair_Homo sapiens_hsa034201.18403431
38Spliceosome_Homo sapiens_hsa030401.14752156
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13024496
40Base excision repair_Homo sapiens_hsa034101.11825784
41Basal cell carcinoma_Homo sapiens_hsa052171.10868764
42Nitrogen metabolism_Homo sapiens_hsa009101.08052571
43Huntingtons disease_Homo sapiens_hsa050161.06235540
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06052242
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03762688
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.03481903
47Hippo signaling pathway_Homo sapiens_hsa043901.03450406
48Taste transduction_Homo sapiens_hsa047421.00703594
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99136841
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.95270187
51Linoleic acid metabolism_Homo sapiens_hsa005910.94687224
52One carbon pool by folate_Homo sapiens_hsa006700.93709652
53GABAergic synapse_Homo sapiens_hsa047270.92617235
54Fatty acid metabolism_Homo sapiens_hsa012120.90380753
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87520334
56Tryptophan metabolism_Homo sapiens_hsa003800.82931500
57Ether lipid metabolism_Homo sapiens_hsa005650.82876154
58Purine metabolism_Homo sapiens_hsa002300.81791498
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81373298
60Cell cycle_Homo sapiens_hsa041100.80960433
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.79286830
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77978473
63beta-Alanine metabolism_Homo sapiens_hsa004100.77921018
64mRNA surveillance pathway_Homo sapiens_hsa030150.76094160
65Axon guidance_Homo sapiens_hsa043600.72862460
66Pyrimidine metabolism_Homo sapiens_hsa002400.71130370
67Morphine addiction_Homo sapiens_hsa050320.69485066
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68178253
69Alzheimers disease_Homo sapiens_hsa050100.68040592
70DNA replication_Homo sapiens_hsa030300.66504463
71Olfactory transduction_Homo sapiens_hsa047400.66381867
72Regulation of autophagy_Homo sapiens_hsa041400.66200406
73Oocyte meiosis_Homo sapiens_hsa041140.65209886
74Circadian rhythm_Homo sapiens_hsa047100.64914854
75Metabolic pathways_Homo sapiens_hsa011000.64165657
76TGF-beta signaling pathway_Homo sapiens_hsa043500.63648097
77Pyruvate metabolism_Homo sapiens_hsa006200.61966947
78Glutamatergic synapse_Homo sapiens_hsa047240.61349031
79Dopaminergic synapse_Homo sapiens_hsa047280.60437417
80Retinol metabolism_Homo sapiens_hsa008300.60366189
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59910189
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59885688
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.58504742
84Wnt signaling pathway_Homo sapiens_hsa043100.56450213
85Cardiac muscle contraction_Homo sapiens_hsa042600.56143983
86Circadian entrainment_Homo sapiens_hsa047130.53682790
87p53 signaling pathway_Homo sapiens_hsa041150.52292491
88Lysine degradation_Homo sapiens_hsa003100.51741714
89Serotonergic synapse_Homo sapiens_hsa047260.49097096
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48697390
91Fatty acid degradation_Homo sapiens_hsa000710.46564033
92Alcoholism_Homo sapiens_hsa050340.45725192
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44984857
94Insulin secretion_Homo sapiens_hsa049110.44935172
95Cocaine addiction_Homo sapiens_hsa050300.44662112
96Chemical carcinogenesis_Homo sapiens_hsa052040.42964951
97Arginine and proline metabolism_Homo sapiens_hsa003300.41482026
98Glycerolipid metabolism_Homo sapiens_hsa005610.36006071
99Vitamin B6 metabolism_Homo sapiens_hsa007500.35354560
100Folate biosynthesis_Homo sapiens_hsa007900.33482267

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