ZNF253

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)4.59816739
2behavioral response to nicotine (GO:0035095)4.04365729
3pyrimidine nucleobase catabolic process (GO:0006208)3.85027844
4neural tube formation (GO:0001841)3.55991953
5negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.49867898
6negative regulation of translation, ncRNA-mediated (GO:0040033)3.49867898
7regulation of translation, ncRNA-mediated (GO:0045974)3.49867898
8negative regulation of DNA-dependent DNA replication (GO:2000104)3.41180170
9presynaptic membrane assembly (GO:0097105)3.36625839
10regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.36356785
11regulation of mitotic spindle checkpoint (GO:1903504)3.36356785
12chromatin remodeling at centromere (GO:0031055)3.34815987
13cullin deneddylation (GO:0010388)3.31328554
14water-soluble vitamin biosynthetic process (GO:0042364)3.24404066
15intraciliary transport (GO:0042073)3.17807623
16nucleobase catabolic process (GO:0046113)3.16204863
17replication fork processing (GO:0031297)3.14931154
18protein deneddylation (GO:0000338)3.12226225
19negative regulation of DNA recombination (GO:0045910)3.09948088
20response to pheromone (GO:0019236)3.09288303
21epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.04770020
22DNA damage response, detection of DNA damage (GO:0042769)3.04145351
23CENP-A containing nucleosome assembly (GO:0034080)3.03689881
24histone H2A acetylation (GO:0043968)3.01779678
25negative regulation of telomere maintenance (GO:0032205)2.98559674
26somatic diversification of immune receptors via somatic mutation (GO:0002566)2.98515913
27somatic hypermutation of immunoglobulin genes (GO:0016446)2.98515913
28presynaptic membrane organization (GO:0097090)2.90106083
29nonmotile primary cilium assembly (GO:0035058)2.89709481
30DNA replication-dependent nucleosome organization (GO:0034723)2.88232407
31DNA replication-dependent nucleosome assembly (GO:0006335)2.88232407
32histone exchange (GO:0043486)2.86859781
33regulation of helicase activity (GO:0051095)2.83841685
34regulation of cilium movement (GO:0003352)2.83081917
35regulation of telomere maintenance (GO:0032204)2.82070932
36regulation of meiosis I (GO:0060631)2.78254097
37kidney morphogenesis (GO:0060993)2.76195567
38fucose catabolic process (GO:0019317)2.76184811
39L-fucose metabolic process (GO:0042354)2.76184811
40L-fucose catabolic process (GO:0042355)2.76184811
41regulation of nuclear cell cycle DNA replication (GO:0033262)2.74223215
42limb bud formation (GO:0060174)2.73600218
43DNA integration (GO:0015074)2.73232154
44RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.73027292
45head development (GO:0060322)2.72522374
46epithelial cilium movement (GO:0003351)2.70766342
47somite rostral/caudal axis specification (GO:0032525)2.67225172
48regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.66235683
49exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.62328213
50nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.61166068
51negative regulation of transcription regulatory region DNA binding (GO:2000678)2.58234043
52cilium morphogenesis (GO:0060271)2.56185988
53detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.56178830
54maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.55501165
55tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.54973265
56RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.54973265
57neuron cell-cell adhesion (GO:0007158)2.54830597
58respiratory chain complex IV assembly (GO:0008535)2.54771435
59recombinational repair (GO:0000725)2.54692954
60preassembly of GPI anchor in ER membrane (GO:0016254)2.52485100
61olfactory bulb development (GO:0021772)2.51820323
62somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.51561847
63somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.51561847
64isotype switching (GO:0045190)2.51561847
65regulation of gene silencing by miRNA (GO:0060964)2.51138217
66regulation of gene silencing by RNA (GO:0060966)2.51138217
67regulation of posttranscriptional gene silencing (GO:0060147)2.51138217
68DNA catabolic process, exonucleolytic (GO:0000738)2.50352147
69protein localization to cilium (GO:0061512)2.49889310
70double-strand break repair via homologous recombination (GO:0000724)2.49346268
71centriole replication (GO:0007099)2.49338557
72protein-cofactor linkage (GO:0018065)2.47691006
73regulation of development, heterochronic (GO:0040034)2.47261391
74DNA replication-independent nucleosome organization (GO:0034724)2.46082149
75DNA replication-independent nucleosome assembly (GO:0006336)2.46082149
76protein neddylation (GO:0045116)2.45997865
77regulation of centriole replication (GO:0046599)2.45965681
78forebrain neuron differentiation (GO:0021879)2.45849729
79somite development (GO:0061053)2.45046686
80DNA deamination (GO:0045006)2.43885825
81synapsis (GO:0007129)2.43651228
82platelet dense granule organization (GO:0060155)2.42064575
83axoneme assembly (GO:0035082)2.41129410
84regulation of DNA endoreduplication (GO:0032875)2.41088338
85cilium organization (GO:0044782)2.40598051
86DNA demethylation (GO:0080111)2.39511336
87photoreceptor cell maintenance (GO:0045494)2.38815913
88retinal cone cell development (GO:0046549)2.37890137
89cilium assembly (GO:0042384)2.35729150
90postreplication repair (GO:0006301)2.35099509
91histone mRNA metabolic process (GO:0008334)2.34613598
92protein complex biogenesis (GO:0070271)2.34604080
93reflex (GO:0060004)2.34479664
94regulation of telomere maintenance via telomerase (GO:0032210)2.34462836
95calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.33047854
96ubiquinone metabolic process (GO:0006743)2.32263201
97positive regulation of mitochondrial fission (GO:0090141)2.31832884
98L-serine metabolic process (GO:0006563)2.31374976
99mitochondrial respiratory chain complex assembly (GO:0033108)2.29828917
100NADH dehydrogenase complex assembly (GO:0010257)2.29620954

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.57614118
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.04058255
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.82076716
4POU3F2_20337985_ChIP-ChIP_501MEL_Human2.79812600
5IGF1R_20145208_ChIP-Seq_DFB_Human2.71178529
6GBX2_23144817_ChIP-Seq_PC3_Human2.70265553
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.66758190
8VDR_22108803_ChIP-Seq_LS180_Human2.61913449
9FUS_26573619_Chip-Seq_HEK293_Human2.54584141
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.45521854
11EWS_26573619_Chip-Seq_HEK293_Human2.45087707
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.44707855
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.34560706
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.33634452
15TAF15_26573619_Chip-Seq_HEK293_Human2.29423893
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.29190159
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.12771222
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.10307762
19P300_19829295_ChIP-Seq_ESCs_Human2.10017610
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.05805369
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02382809
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87909046
23ELK1_19687146_ChIP-ChIP_HELA_Human1.87686255
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.80584400
25E2F4_17652178_ChIP-ChIP_JURKAT_Human1.79801454
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79110245
27POU5F1_16153702_ChIP-ChIP_HESCs_Human1.76330547
28IRF1_19129219_ChIP-ChIP_H3396_Human1.75575447
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.70807428
30EZH2_22144423_ChIP-Seq_EOC_Human1.64061011
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.62331085
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57696347
33ER_23166858_ChIP-Seq_MCF-7_Human1.49900450
34MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49801576
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49683908
36RBPJ_22232070_ChIP-Seq_NCS_Mouse1.48498026
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48312407
38MYC_18940864_ChIP-ChIP_HL60_Human1.47643514
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47348912
40CBP_20019798_ChIP-Seq_JUKART_Human1.46981653
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46981653
42SMAD4_21799915_ChIP-Seq_A2780_Human1.44596962
43VDR_23849224_ChIP-Seq_CD4+_Human1.43766219
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42496969
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.41785935
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41415161
47PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37963465
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36573602
49GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.36528719
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.35514015
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34707953
52SOX2_16153702_ChIP-ChIP_HESCs_Human1.33000318
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.31949889
54CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.31769755
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31573032
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31240475
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.30269027
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28015941
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.27425341
60STAT3_23295773_ChIP-Seq_U87_Human1.26653196
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26629381
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26629381
63KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26068342
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25160291
65BCAT_22108803_ChIP-Seq_LS180_Human1.24695661
66CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.24438153
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24308174
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21821761
69KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.21143189
70RNF2_27304074_Chip-Seq_NSC_Mouse1.20695783
71SOX2_19829295_ChIP-Seq_ESCs_Human1.20393722
72NANOG_19829295_ChIP-Seq_ESCs_Human1.20393722
73AR_25329375_ChIP-Seq_VCAP_Human1.19918620
74ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19203894
75NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.18820386
76TCF4_23295773_ChIP-Seq_U87_Human1.16799660
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.16255548
78TCF4_22108803_ChIP-Seq_LS180_Human1.13146366
79FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12806324
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.12748340
81RUNX2_22187159_ChIP-Seq_PCA_Human1.12111764
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11283985
83TP53_22573176_ChIP-Seq_HFKS_Human1.11277378
84ETS1_20019798_ChIP-Seq_JURKAT_Human1.10210498
85RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09782433
86NANOG_16153702_ChIP-ChIP_HESCs_Human1.08416770
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06982040
88FOXP3_21729870_ChIP-Seq_TREG_Human1.06185721
89EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05714125
90FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04466253
91P53_22387025_ChIP-Seq_ESCs_Mouse1.03980749
92CREB1_15753290_ChIP-ChIP_HEK293T_Human1.03884260
93CBX2_27304074_Chip-Seq_ESCs_Mouse1.03704956
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99781750
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98806042
96BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98451234
97CRX_20693478_ChIP-Seq_RETINA_Mouse0.98449991
98TP63_19390658_ChIP-ChIP_HaCaT_Human0.98345590
99YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97937509
100FLI1_21867929_ChIP-Seq_TH2_Mouse0.96446853

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.06172119
2MP0002102_abnormal_ear_morphology3.02404612
3MP0006292_abnormal_olfactory_placode2.72194286
4MP0003787_abnormal_imprinting2.54327187
5MP0003880_abnormal_central_pattern2.40911549
6MP0001529_abnormal_vocalization2.29880446
7MP0008058_abnormal_DNA_repair2.24943435
8MP0003122_maternal_imprinting2.19064555
9MP0008789_abnormal_olfactory_epithelium2.04470906
10MP0003121_genomic_imprinting2.03646207
11MP0006072_abnormal_retinal_apoptosis1.98033366
12MP0003890_abnormal_embryonic-extraembry1.92837593
13MP0002638_abnormal_pupillary_reflex1.87553260
14MP0004133_heterotaxia1.83431070
15MP0000631_abnormal_neuroendocrine_gland1.78348539
16MP0005394_taste/olfaction_phenotype1.77503959
17MP0005499_abnormal_olfactory_system1.77503959
18MP0001984_abnormal_olfaction1.76059962
19MP0002751_abnormal_autonomic_nervous1.73705540
20MP0001188_hyperpigmentation1.71487171
21MP0002736_abnormal_nociception_after1.69526218
22MP0001968_abnormal_touch/_nociception1.69138749
23MP0003136_yellow_coat_color1.68837898
24MP0003195_calcinosis1.68384794
25MP0002837_dystrophic_cardiac_calcinosis1.64186885
26MP0001293_anophthalmia1.63416818
27MP0002938_white_spotting1.63325612
28MP0005253_abnormal_eye_physiology1.58875903
29MP0003567_abnormal_fetal_cardiomyocyte1.56527467
30MP0010094_abnormal_chromosome_stability1.56347394
31MP0005645_abnormal_hypothalamus_physiol1.55442304
32MP0008995_early_reproductive_senescence1.54171863
33MP0001485_abnormal_pinna_reflex1.54125131
34MP0005551_abnormal_eye_electrophysiolog1.51910758
35MP0006276_abnormal_autonomic_nervous1.50415536
36MP0005646_abnormal_pituitary_gland1.45192848
37MP0009046_muscle_twitch1.42384080
38MP0003937_abnormal_limbs/digits/tail_de1.42157929
39MP0004147_increased_porphyrin_level1.41935922
40MP0003718_maternal_effect1.40875280
41MP0000778_abnormal_nervous_system1.39968854
42MP0000372_irregular_coat_pigmentation1.37022870
43MP0009745_abnormal_behavioral_response1.36034255
44MP0003693_abnormal_embryo_hatching1.34268615
45MP0003119_abnormal_digestive_system1.33925854
46MP0005084_abnormal_gallbladder_morpholo1.30948734
47MP0002272_abnormal_nervous_system1.30032512
48MP0004885_abnormal_endolymph1.30015572
49MP0001486_abnormal_startle_reflex1.27987353
50MP0002653_abnormal_ependyma_morphology1.27729293
51MP0000049_abnormal_middle_ear1.27716093
52MP0004270_analgesia1.21857126
53MP0000569_abnormal_digit_pigmentation1.20189661
54MP0004142_abnormal_muscle_tone1.19176268
55MP0010386_abnormal_urinary_bladder1.18949546
56MP0005367_renal/urinary_system_phenotyp1.18366587
57MP0000516_abnormal_urinary_system1.18366587
58MP0002254_reproductive_system_inflammat1.17072937
59MP0002233_abnormal_nose_morphology1.17016591
60MP0003786_premature_aging1.14783468
61MP0002557_abnormal_social/conspecific_i1.09239191
62MP0008872_abnormal_physiological_respon1.07779226
63MP0004215_abnormal_myocardial_fiber1.07302840
64MP0003137_abnormal_impulse_conducting1.06132617
65MP0000647_abnormal_sebaceous_gland1.03792688
66MP0004145_abnormal_muscle_electrophysio1.03445618
67MP0003938_abnormal_ear_development1.03257192
68MP0002572_abnormal_emotion/affect_behav1.02618635
69MP0008057_abnormal_DNA_replication1.02282720
70MP0002184_abnormal_innervation1.01749010
71MP0002734_abnormal_mechanical_nocicepti1.01114991
72MP0000427_abnormal_hair_cycle0.99084056
73MP0009697_abnormal_copulation0.98971749
74MP0004924_abnormal_behavior0.97983387
75MP0005386_behavior/neurological_phenoty0.97983387
76MP0003635_abnormal_synaptic_transmissio0.96895070
77MP0001286_abnormal_eye_development0.96502727
78MP0002735_abnormal_chemical_nociception0.95802883
79MP0002234_abnormal_pharynx_morphology0.92406006
80MP0005187_abnormal_penis_morphology0.92174887
81MP0003011_delayed_dark_adaptation0.91389998
82MP0001986_abnormal_taste_sensitivity0.90980643
83MP0001929_abnormal_gametogenesis0.89955546
84MP0005075_abnormal_melanosome_morpholog0.89574965
85MP0002063_abnormal_learning/memory/cond0.89314873
86MP0005391_vision/eye_phenotype0.88004854
87MP0002752_abnormal_somatic_nervous0.86452456
88MP0003698_abnormal_male_reproductive0.86262934
89MP0001177_atelectasis0.85896710
90MP0002210_abnormal_sex_determination0.83353720
91MP0003861_abnormal_nervous_system0.81618557
92MP0002067_abnormal_sensory_capabilities0.81543490
93MP0006035_abnormal_mitochondrial_morpho0.81159053
94MP0000653_abnormal_sex_gland0.79995598
95MP0003755_abnormal_palate_morphology0.78634409
96MP0004043_abnormal_pH_regulation0.78584256
97MP0005248_abnormal_Harderian_gland0.78561590
98MP0001145_abnormal_male_reproductive0.78046719
99MP0005195_abnormal_posterior_eye0.77989969
100MP0002064_seizures0.77220798

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)3.82815268
2Colon cancer (HP:0003003)3.39851251
3Pancreatic cysts (HP:0001737)3.23373734
4Pancreatic fibrosis (HP:0100732)3.00042692
5True hermaphroditism (HP:0010459)2.98933405
6Abnormality of midbrain morphology (HP:0002418)2.97054687
7Molar tooth sign on MRI (HP:0002419)2.97054687
8Intestinal atresia (HP:0011100)2.96978423
9Medial flaring of the eyebrow (HP:0010747)2.91740211
10Nephronophthisis (HP:0000090)2.87333269
11Methylmalonic acidemia (HP:0002912)2.73615515
12Chronic hepatic failure (HP:0100626)2.65261957
13Gait imbalance (HP:0002141)2.57086447
14Congenital primary aphakia (HP:0007707)2.54817974
15Genital tract atresia (HP:0001827)2.45962969
16Nephrogenic diabetes insipidus (HP:0009806)2.45489376
17Abnormality of the renal medulla (HP:0100957)2.45328670
18Hyperglycinemia (HP:0002154)2.40686555
19Septo-optic dysplasia (HP:0100842)2.37804471
20Abolished electroretinogram (ERG) (HP:0000550)2.37732352
21Progressive inability to walk (HP:0002505)2.37008297
22Vaginal atresia (HP:0000148)2.35504599
23Thyroid-stimulating hormone excess (HP:0002925)2.32111103
24Abnormality of the renal cortex (HP:0011035)2.29272300
25Volvulus (HP:0002580)2.28686075
26Drooling (HP:0002307)2.25552518
27Abnormality of glycine metabolism (HP:0010895)2.23348565
28Abnormality of serine family amino acid metabolism (HP:0010894)2.23348565
29Lissencephaly (HP:0001339)2.18797700
30Inability to walk (HP:0002540)2.16648082
31Meckel diverticulum (HP:0002245)2.16645621
32Hypothermia (HP:0002045)2.16537379
33Aplasia/Hypoplasia of the uvula (HP:0010293)2.16099357
34Abnormality of the ileum (HP:0001549)2.14880473
35Broad-based gait (HP:0002136)2.13085914
36Optic nerve hypoplasia (HP:0000609)2.12968051
37Hepatoblastoma (HP:0002884)2.12583273
38Hyperglycinuria (HP:0003108)2.11358574
39Pendular nystagmus (HP:0012043)2.11339855
40Abnormal biliary tract physiology (HP:0012439)2.10192273
41Bile duct proliferation (HP:0001408)2.10192273
42Abnormality of chromosome stability (HP:0003220)2.04764221
43Aplasia/Hypoplasia of the tibia (HP:0005772)2.04213038
44Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.02252577
45Ependymoma (HP:0002888)2.02168163
46Excessive salivation (HP:0003781)2.00831720
47Methylmalonic aciduria (HP:0012120)1.98036708
48Renal cortical cysts (HP:0000803)1.96665873
49Aplasia/Hypoplasia of the tongue (HP:0010295)1.96664031
50Neoplasm of the adrenal cortex (HP:0100641)1.95174599
51Oligodactyly (hands) (HP:0001180)1.94206412
52Supernumerary spleens (HP:0009799)1.91555491
53Abnormality of the metopic suture (HP:0005556)1.90810747
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88545774
55Abnormality of alanine metabolism (HP:0010916)1.88545774
56Hyperalaninemia (HP:0003348)1.88545774
57Abnormality of serum amino acid levels (HP:0003112)1.85915298
58Poor coordination (HP:0002370)1.85887888
59Postaxial hand polydactyly (HP:0001162)1.84778025
60Sclerocornea (HP:0000647)1.84422270
61Anencephaly (HP:0002323)1.83520936
62Glioma (HP:0009733)1.82777328
63Acute necrotizing encephalopathy (HP:0006965)1.82077763
64Hyperinsulinemic hypoglycemia (HP:0000825)1.81325781
65Abnormal lung lobation (HP:0002101)1.80929534
66Short tibia (HP:0005736)1.80851927
67Protruding tongue (HP:0010808)1.80466652
68Dandy-Walker malformation (HP:0001305)1.80382204
69Broad foot (HP:0001769)1.79328992
70Renal hypoplasia (HP:0000089)1.77875125
71Sloping forehead (HP:0000340)1.77822430
72Postaxial foot polydactyly (HP:0001830)1.76697680
73Acute encephalopathy (HP:0006846)1.76591511
74Congenital stationary night blindness (HP:0007642)1.76518636
75Pancreatic islet-cell hyperplasia (HP:0004510)1.76277446
76Anophthalmia (HP:0000528)1.76205137
77Hyperventilation (HP:0002883)1.76126230
78Progressive macrocephaly (HP:0004481)1.75596146
79Astrocytoma (HP:0009592)1.75443116
80Abnormality of the astrocytes (HP:0100707)1.75443116
81Abnormality of the duodenum (HP:0002246)1.74319214
82Specific learning disability (HP:0001328)1.73605450
83Abnormality of vitamin B metabolism (HP:0004340)1.73559532
84Growth hormone deficiency (HP:0000824)1.73358140
85Gastrointestinal atresia (HP:0002589)1.72901161
86Aqueductal stenosis (HP:0002410)1.71883427
87Cystic liver disease (HP:0006706)1.70988327
883-Methylglutaconic aciduria (HP:0003535)1.70841145
89Scrotal hypoplasia (HP:0000046)1.70737498
90Preaxial hand polydactyly (HP:0001177)1.70571385
91Narrow forehead (HP:0000341)1.70171003
92Medulloblastoma (HP:0002885)1.69196853
93Labial hypoplasia (HP:0000066)1.68708528
94Gaze-evoked nystagmus (HP:0000640)1.67927954
95Chromosomal breakage induced by crosslinking agents (HP:0003221)1.67580931
96Pachygyria (HP:0001302)1.67563926
97Neoplasm of the oral cavity (HP:0100649)1.66866786
98Aplasia/Hypoplasia of the sternum (HP:0006714)1.65194506
99Type II lissencephaly (HP:0007260)1.65049120
100Cupped ear (HP:0000378)1.64397033

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.55729071
2WNK33.28629477
3TRIM283.07388375
4MAP4K22.93469329
5NUAK12.62026471
6MAP3K42.57278922
7MKNK22.34274745
8ZAK2.30156937
9TNIK2.17743572
10BCR2.16683727
11BMPR1B2.14930334
12CASK1.99350613
13MKNK11.95457114
14SRPK11.84165749
15MAPK131.82291959
16MARK11.71078731
17MAP2K71.63662479
18ACVR1B1.60096413
19PLK31.57897486
20DYRK21.57091002
21ERBB31.52061543
22GRK11.49437641
23CSNK1G11.48457914
24TSSK61.47271271
25CSNK1G21.42226793
26ADRBK21.42188762
27PLK41.40652424
28EIF2AK31.37187677
29VRK11.34104420
30CSNK1G31.31817289
31BUB11.30679189
32PINK11.27945030
33BRSK21.27480059
34PLK21.26762801
35STK38L1.17320739
36FGFR21.17291802
37NEK11.14305081
38DYRK31.12335328
39CSNK1A1L1.07676195
40CDC71.06908871
41RPS6KA41.06664974
42CDK191.03423004
43TTK1.02396431
44INSRR0.99752678
45BCKDK0.96940924
46PAK30.96753099
47OXSR10.96177434
48WEE10.93185562
49TLK10.89794945
50PLK10.89253712
51PRKCE0.87675771
52MST40.86119608
53OBSCN0.85433941
54EPHA40.82922315
55PRKCG0.82649728
56PNCK0.77686379
57BRD40.77605895
58MINK10.73654542
59VRK20.72565329
60TAF10.70328292
61AKT30.69912368
62NLK0.63700690
63ATR0.63301091
64ATM0.63107986
65TGFBR10.61965266
66STK30.60823335
67PASK0.59702581
68TIE10.59291584
69STK390.58030202
70DYRK1A0.57768401
71WNK40.54674598
72NTRK30.52186295
73NTRK20.48851588
74TAOK30.48371192
75NME10.48311335
76STK160.47155059
77RPS6KA50.46081239
78CSNK1A10.45956519
79MAP2K40.45937997
80CSNK1D0.44249443
81PBK0.44240439
82CDK30.44097513
83SIK30.42700044
84CSNK1E0.42336317
85CAMK2A0.41950050
86PKN10.41092446
87DAPK20.40654540
88PHKG10.40257368
89PHKG20.40257368
90YES10.39845156
91SGK20.39666254
92EIF2AK20.39283862
93UHMK10.38751905
94CHEK20.38117773
95FLT30.37889583
96EPHA30.37609453
97AURKB0.36898643
98CAMKK20.36462895
99NEK20.35572660
100LATS10.34895484

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.95889797
2Protein export_Homo sapiens_hsa030602.89864606
3Propanoate metabolism_Homo sapiens_hsa006402.45009246
4Nicotine addiction_Homo sapiens_hsa050332.33478768
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.31734007
6Fanconi anemia pathway_Homo sapiens_hsa034602.29856262
7Basal transcription factors_Homo sapiens_hsa030222.29171873
8Butanoate metabolism_Homo sapiens_hsa006502.25473002
9Non-homologous end-joining_Homo sapiens_hsa034502.19183591
10RNA polymerase_Homo sapiens_hsa030202.18045863
11Phototransduction_Homo sapiens_hsa047442.06938127
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.99667527
13Homologous recombination_Homo sapiens_hsa034401.95346832
14RNA degradation_Homo sapiens_hsa030181.95056344
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.92047658
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.88087464
17Selenocompound metabolism_Homo sapiens_hsa004501.86596111
18Steroid biosynthesis_Homo sapiens_hsa001001.84696842
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.75690896
20Mismatch repair_Homo sapiens_hsa034301.70699983
21Oxidative phosphorylation_Homo sapiens_hsa001901.59311169
22RNA transport_Homo sapiens_hsa030131.54086869
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52740022
24Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.44867421
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.42637257
26Parkinsons disease_Homo sapiens_hsa050121.40139777
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.38779982
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.31033815
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.30681415
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30316988
31Linoleic acid metabolism_Homo sapiens_hsa005911.30309444
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.29402726
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.28917178
34Taste transduction_Homo sapiens_hsa047421.26302384
35Proteasome_Homo sapiens_hsa030501.25236347
36Spliceosome_Homo sapiens_hsa030401.24113305
37Nitrogen metabolism_Homo sapiens_hsa009101.20209844
38Peroxisome_Homo sapiens_hsa041461.18363879
39GABAergic synapse_Homo sapiens_hsa047271.17537314
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15404628
41Regulation of autophagy_Homo sapiens_hsa041401.09648174
42Ether lipid metabolism_Homo sapiens_hsa005651.08238098
43Vitamin B6 metabolism_Homo sapiens_hsa007501.06900323
44Huntingtons disease_Homo sapiens_hsa050161.05801843
45Tryptophan metabolism_Homo sapiens_hsa003801.05227437
46One carbon pool by folate_Homo sapiens_hsa006701.04693237
47Caffeine metabolism_Homo sapiens_hsa002321.01922723
48Base excision repair_Homo sapiens_hsa034101.01038413
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.97630655
50Purine metabolism_Homo sapiens_hsa002300.92624433
51beta-Alanine metabolism_Homo sapiens_hsa004100.91469203
52Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90661756
53Olfactory transduction_Homo sapiens_hsa047400.90309238
54Fatty acid elongation_Homo sapiens_hsa000620.89818417
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88850747
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.88832214
57Morphine addiction_Homo sapiens_hsa050320.87883423
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.86402986
59Circadian entrainment_Homo sapiens_hsa047130.81771672
60Retinol metabolism_Homo sapiens_hsa008300.80621507
61mRNA surveillance pathway_Homo sapiens_hsa030150.80510969
62Cell cycle_Homo sapiens_hsa041100.80136102
63Nucleotide excision repair_Homo sapiens_hsa034200.80012867
64Oocyte meiosis_Homo sapiens_hsa041140.79468950
65DNA replication_Homo sapiens_hsa030300.79153473
66Serotonergic synapse_Homo sapiens_hsa047260.72633161
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70746288
68Pyrimidine metabolism_Homo sapiens_hsa002400.70671351
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70455184
70Glutamatergic synapse_Homo sapiens_hsa047240.70229480
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70067189
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69303873
73Dopaminergic synapse_Homo sapiens_hsa047280.68940259
74Circadian rhythm_Homo sapiens_hsa047100.68551873
75Fatty acid metabolism_Homo sapiens_hsa012120.65489614
76Alzheimers disease_Homo sapiens_hsa050100.65260677
77Metabolic pathways_Homo sapiens_hsa011000.64512894
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62927580
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.62830026
80Cardiac muscle contraction_Homo sapiens_hsa042600.62054290
81Pyruvate metabolism_Homo sapiens_hsa006200.61586724
82Insulin secretion_Homo sapiens_hsa049110.59944111
83Chemical carcinogenesis_Homo sapiens_hsa052040.58249932
84Fatty acid degradation_Homo sapiens_hsa000710.57067951
85Basal cell carcinoma_Homo sapiens_hsa052170.54135353
86p53 signaling pathway_Homo sapiens_hsa041150.53727583
87Collecting duct acid secretion_Homo sapiens_hsa049660.53540784
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51968726
89Hedgehog signaling pathway_Homo sapiens_hsa043400.50774634
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50054002
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49362213
92ABC transporters_Homo sapiens_hsa020100.48067928
93Alcoholism_Homo sapiens_hsa050340.47305516
94Lysine degradation_Homo sapiens_hsa003100.46408371
95Fat digestion and absorption_Homo sapiens_hsa049750.44904306
96Amphetamine addiction_Homo sapiens_hsa050310.44158446
97Vitamin digestion and absorption_Homo sapiens_hsa049770.42810721
98Long-term depression_Homo sapiens_hsa047300.41286613
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38795380
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36481757

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