ZNF25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.62705536
2regulation of synaptic vesicle exocytosis (GO:2000300)4.70734920
3membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.66611907
4glutamate secretion (GO:0014047)4.63664442
5synaptic vesicle exocytosis (GO:0016079)4.62191813
6neurotransmitter-gated ion channel clustering (GO:0072578)4.60447863
7pyrimidine nucleobase catabolic process (GO:0006208)4.53532200
8synaptic vesicle docking involved in exocytosis (GO:0016081)4.47954418
9neuron cell-cell adhesion (GO:0007158)4.44984238
10postsynaptic membrane organization (GO:0001941)4.38337101
11regulation of short-term neuronal synaptic plasticity (GO:0048172)4.33621777
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.29645866
13neuronal action potential propagation (GO:0019227)4.24818448
14regulation of synaptic vesicle transport (GO:1902803)4.16081962
15presynaptic membrane assembly (GO:0097105)4.11779420
16gamma-aminobutyric acid transport (GO:0015812)4.05270265
17presynaptic membrane organization (GO:0097090)4.01792940
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.00722044
19neurotransmitter secretion (GO:0007269)3.97234669
20positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.96382188
21axonal fasciculation (GO:0007413)3.93320360
22vocalization behavior (GO:0071625)3.93042776
23protein localization to synapse (GO:0035418)3.85566573
24nucleobase catabolic process (GO:0046113)3.78778573
25synaptic transmission, glutamatergic (GO:0035249)3.77278893
26positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.72422114
27negative regulation of synaptic transmission, GABAergic (GO:0032229)3.71892149
28regulation of synapse structural plasticity (GO:0051823)3.71227303
29establishment of mitochondrion localization (GO:0051654)3.70405094
30neuron recognition (GO:0008038)3.65921188
31locomotory exploration behavior (GO:0035641)3.60611713
32positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.59818846
33dendritic spine morphogenesis (GO:0060997)3.59122970
34auditory behavior (GO:0031223)3.52162308
35neuron-neuron synaptic transmission (GO:0007270)3.49238267
36cerebellar granule cell differentiation (GO:0021707)3.46773611
37glutamate receptor signaling pathway (GO:0007215)3.44408611
38cellular potassium ion homeostasis (GO:0030007)3.41171461
39regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.40064030
40regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.39567039
41detection of calcium ion (GO:0005513)3.39074782
42positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.38696427
43exploration behavior (GO:0035640)3.37245603
44neuronal ion channel clustering (GO:0045161)3.34425891
45synapse assembly (GO:0007416)3.33284207
46membrane depolarization during action potential (GO:0086010)3.28558620
47positive regulation of synapse maturation (GO:0090129)3.27892535
48cerebellar Purkinje cell differentiation (GO:0021702)3.23320011
49synaptic vesicle endocytosis (GO:0048488)3.19597375
50regulation of neurotransmitter secretion (GO:0046928)3.16759642
51regulation of glutamate receptor signaling pathway (GO:1900449)3.12850944
52cell migration in hindbrain (GO:0021535)3.12037446
53startle response (GO:0001964)3.11451125
54neurotransmitter transport (GO:0006836)3.11033186
55dendrite morphogenesis (GO:0048813)3.10265782
56proline transport (GO:0015824)3.09428689
57regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.09323801
58regulation of vesicle fusion (GO:0031338)3.08464538
59response to auditory stimulus (GO:0010996)3.07685087
60neuromuscular synaptic transmission (GO:0007274)3.04933810
61positive regulation of synapse assembly (GO:0051965)3.04276118
62regulation of cell communication by electrical coupling (GO:0010649)3.03979619
63regulation of neurotransmitter levels (GO:0001505)3.03261731
64gamma-aminobutyric acid signaling pathway (GO:0007214)3.00635717
65transmission of nerve impulse (GO:0019226)2.98315968
66regulation of neuronal synaptic plasticity (GO:0048168)2.98202567
67regulation of excitatory postsynaptic membrane potential (GO:0060079)2.95130392
68positive regulation of dendritic spine development (GO:0060999)2.93519836
69regulation of neurotransmitter transport (GO:0051588)2.93384122
70regulation of dendritic spine morphogenesis (GO:0061001)2.93286225
71regulation of dendritic spine development (GO:0060998)2.91815235
72negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.91279915
73regulation of synaptic transmission, glutamatergic (GO:0051966)2.89389262
74positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.87895785
75regulation of postsynaptic membrane potential (GO:0060078)2.87768114
76regulation of synapse maturation (GO:0090128)2.87542453
77urinary tract smooth muscle contraction (GO:0014848)2.85178883
78regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.84907377
79organelle transport along microtubule (GO:0072384)2.84881013
80regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.82462809
81sarcoplasmic reticulum calcium ion transport (GO:0070296)2.82090075
82central nervous system projection neuron axonogenesis (GO:0021952)2.79038044
83regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.78677299
84negative regulation of cytosolic calcium ion concentration (GO:0051481)2.78221434
85membrane depolarization (GO:0051899)2.77682978
86glycosphingolipid biosynthetic process (GO:0006688)2.77054884
87positive regulation of membrane potential (GO:0045838)2.75966153
88synapse organization (GO:0050808)2.75533849
89regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.74792705
90adult walking behavior (GO:0007628)2.74731018
91regulation of synapse assembly (GO:0051963)2.73909641
92positive regulation of mitochondrial fission (GO:0090141)2.70825824
93regulation of respiratory system process (GO:0044065)2.69057994
94establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.68917874
95mitochondrion transport along microtubule (GO:0047497)2.68917874
96sodium ion export (GO:0071436)2.68781218
97regulation of voltage-gated calcium channel activity (GO:1901385)2.68493384
98long-term memory (GO:0007616)2.67738896
99cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.67355112
100positive regulation of dendritic spine morphogenesis (GO:0061003)2.67309080

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.27170267
2GBX2_23144817_ChIP-Seq_PC3_Human3.54445783
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.87794371
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.54098105
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.45227390
6IGF1R_20145208_ChIP-Seq_DFB_Human2.34852779
7REST_21632747_ChIP-Seq_MESCs_Mouse2.32984457
8TAF15_26573619_Chip-Seq_HEK293_Human2.32553741
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.23558969
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.16697292
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.09267973
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03336967
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.02917250
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.98245657
15CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.97686765
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.96858938
17REST_18959480_ChIP-ChIP_MESCs_Mouse1.94969628
18CDX2_19796622_ChIP-Seq_MESCs_Mouse1.92794344
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92061798
20DROSHA_22980978_ChIP-Seq_HELA_Human1.90602280
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.89076054
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.87274596
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.84548043
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.83885885
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82686719
26SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.79017726
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78581235
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.78111395
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.77657397
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.77657397
31MTF2_20144788_ChIP-Seq_MESCs_Mouse1.76776453
32JARID2_20075857_ChIP-Seq_MESCs_Mouse1.76398185
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76312458
34SMAD4_21799915_ChIP-Seq_A2780_Human1.76007547
35RBPJ_22232070_ChIP-Seq_NCS_Mouse1.67758596
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.65946314
37OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64649036
38RNF2_27304074_Chip-Seq_NSC_Mouse1.62485880
39RNF2_27304074_Chip-Seq_ESCs_Mouse1.62118831
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61083706
41P300_19829295_ChIP-Seq_ESCs_Human1.58006008
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.57768124
43RARB_27405468_Chip-Seq_BRAIN_Mouse1.57585747
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55358549
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.53857920
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.48487442
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44003269
48AR_21572438_ChIP-Seq_LNCaP_Human1.43894843
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43515658
50ZNF274_21170338_ChIP-Seq_K562_Hela1.42802641
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42608443
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.42462645
53NR3C1_23031785_ChIP-Seq_PC12_Mouse1.41707517
54FUS_26573619_Chip-Seq_HEK293_Human1.37897475
55STAT3_23295773_ChIP-Seq_U87_Human1.36003587
56AR_25329375_ChIP-Seq_VCAP_Human1.35587571
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.34201745
58SOX2_21211035_ChIP-Seq_LN229_Gbm1.33173839
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32755507
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27750611
61TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.26712111
62TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25796027
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25210385
64TCF4_23295773_ChIP-Seq_U87_Human1.24332329
65NANOG_18555785_Chip-Seq_ESCs_Mouse1.24041772
66VDR_22108803_ChIP-Seq_LS180_Human1.23689432
67CBP_20019798_ChIP-Seq_JUKART_Human1.22681250
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22681250
69TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20240263
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20238309
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14914642
72P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13478251
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12463152
74NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12290932
75NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12290932
76PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.11670421
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10583468
78POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10583468
79ER_23166858_ChIP-Seq_MCF-7_Human1.09674770
80BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08608917
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08291917
82TAL1_26923725_Chip-Seq_HPCs_Mouse1.06741765
83AR_19668381_ChIP-Seq_PC3_Human1.06682175
84EP300_21415370_ChIP-Seq_HL-1_Mouse1.05801053
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.05661514
86BCAT_22108803_ChIP-Seq_LS180_Human1.04574448
87RUNX2_22187159_ChIP-Seq_PCA_Human1.04243198
88LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04220325
89RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03560511
90FLI1_21867929_ChIP-Seq_TH2_Mouse1.02753261
91P53_22387025_ChIP-Seq_ESCs_Mouse1.02352969
92WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01991134
93TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01324244
94YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00675275
95KDM2B_26808549_Chip-Seq_REH_Human1.00239888
96MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99733158
97SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98581926
98FLI1_27457419_Chip-Seq_LIVER_Mouse0.98578840
99RING1B_27294783_Chip-Seq_ESCs_Mouse0.97244970
100JUN_21703547_ChIP-Seq_K562_Human0.95743308

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.89723589
2MP0003880_abnormal_central_pattern4.24361701
3MP0004270_analgesia4.04827977
4MP0005423_abnormal_somatic_nervous3.38496136
5MP0003635_abnormal_synaptic_transmissio3.32451303
6MP0002063_abnormal_learning/memory/cond2.81838392
7MP0009046_muscle_twitch2.74135867
8MP0009745_abnormal_behavioral_response2.73126263
9MP0002064_seizures2.71434891
10MP0002822_catalepsy2.68976034
11MP0002272_abnormal_nervous_system2.67373389
12MP0001968_abnormal_touch/_nociception2.39029971
13MP0002734_abnormal_mechanical_nocicepti2.37123118
14MP0001486_abnormal_startle_reflex2.35858404
15MP0002572_abnormal_emotion/affect_behav2.34471948
16MP0002735_abnormal_chemical_nociception2.20348776
17MP0006276_abnormal_autonomic_nervous2.15849270
18MP0000569_abnormal_digit_pigmentation2.14811782
19MP0000778_abnormal_nervous_system2.13092979
20MP0001501_abnormal_sleep_pattern2.05504208
21MP0001984_abnormal_olfaction2.05398683
22MP0003122_maternal_imprinting1.99104830
23MP0004145_abnormal_muscle_electrophysio1.92523887
24MP0002736_abnormal_nociception_after1.82790411
25MP0002067_abnormal_sensory_capabilities1.81365749
26MP0001970_abnormal_pain_threshold1.77516938
27MP0003787_abnormal_imprinting1.75343015
28MP0002733_abnormal_thermal_nociception1.70199238
29MP0008569_lethality_at_weaning1.70121282
30MP0001529_abnormal_vocalization1.69586835
31MP0002638_abnormal_pupillary_reflex1.68425802
32MP0004811_abnormal_neuron_physiology1.68219160
33MP0005386_behavior/neurological_phenoty1.67049248
34MP0004924_abnormal_behavior1.67049248
35MP0000751_myopathy1.62871252
36MP0004885_abnormal_endolymph1.58893661
37MP0001440_abnormal_grooming_behavior1.57391323
38MP0003879_abnormal_hair_cell1.54701262
39MP0002557_abnormal_social/conspecific_i1.53227153
40MP0004142_abnormal_muscle_tone1.52365017
41MP0002184_abnormal_innervation1.48654581
42MP0002882_abnormal_neuron_morphology1.45021274
43MP0010386_abnormal_urinary_bladder1.44089220
44MP0000955_abnormal_spinal_cord1.43633629
45MP0003633_abnormal_nervous_system1.43532883
46MP0001502_abnormal_circadian_rhythm1.42519303
47MP0005645_abnormal_hypothalamus_physiol1.39107222
48MP0002066_abnormal_motor_capabilities/c1.34007080
49MP0001905_abnormal_dopamine_level1.26641905
50MP0002909_abnormal_adrenal_gland1.26532559
51MP0004130_abnormal_muscle_cell1.23750952
52MP0004484_altered_response_of1.22517239
53MP0005187_abnormal_penis_morphology1.18394123
54MP0003631_nervous_system_phenotype1.17396963
55MP0004215_abnormal_myocardial_fiber1.16647983
56MP0003690_abnormal_glial_cell1.15231667
57MP0003329_amyloid_beta_deposits1.15015258
58MP0001986_abnormal_taste_sensitivity1.14655355
59MP0009780_abnormal_chondrocyte_physiolo1.13323812
60MP0000013_abnormal_adipose_tissue1.11747028
61MP0003121_genomic_imprinting1.10202883
62MP0005646_abnormal_pituitary_gland1.09996277
63MP0000749_muscle_degeneration1.08990531
64MP0002229_neurodegeneration1.05550847
65MP0005551_abnormal_eye_electrophysiolog1.04117132
66MP0003137_abnormal_impulse_conducting1.01746078
67MP0005620_abnormal_muscle_contractility1.01068072
68MP0002837_dystrophic_cardiac_calcinosis1.00980482
69MP0004036_abnormal_muscle_relaxation1.00135790
70MP0002152_abnormal_brain_morphology0.97692317
71MP0000920_abnormal_myelination0.97574441
72MP0002332_abnormal_exercise_endurance0.97248898
73MP0001177_atelectasis0.94084897
74MP0004742_abnormal_vestibular_system0.92346140
75MP0005535_abnormal_body_temperature0.89949683
76MP0004085_abnormal_heartbeat0.89648848
77MP0002106_abnormal_muscle_physiology0.86030482
78MP0004043_abnormal_pH_regulation0.85745974
79MP0003646_muscle_fatigue0.84465992
80MP0003634_abnormal_glial_cell0.83028801
81MP0002752_abnormal_somatic_nervous0.82629011
82MP0003632_abnormal_nervous_system0.78795335
83MP0001963_abnormal_hearing_physiology0.76992543
84MP0008874_decreased_physiological_sensi0.76531062
85MP0002069_abnormal_eating/drinking_beha0.76373915
86MP0000747_muscle_weakness0.76126173
87MP0004084_abnormal_cardiac_muscle0.76004194
88MP0001188_hyperpigmentation0.74416066
89MP0005253_abnormal_eye_physiology0.74384643
90MP0002102_abnormal_ear_morphology0.72126349
91MP0004510_myositis0.70944596
92MP0005369_muscle_phenotype0.70663352
93MP0002972_abnormal_cardiac_muscle0.69579998
94MP0001299_abnormal_eye_distance/0.69562592
95MP0000759_abnormal_skeletal_muscle0.65925452
96MP0001943_abnormal_respiration0.65603424
97MP0001485_abnormal_pinna_reflex0.65174545
98MP0005394_taste/olfaction_phenotype0.63491126
99MP0005499_abnormal_olfactory_system0.63491126
100MP0003221_abnormal_cardiomyocyte_apopto0.63254129

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.48422198
2Myokymia (HP:0002411)4.79232450
3Febrile seizures (HP:0002373)4.71357834
4Focal seizures (HP:0007359)4.65404303
5Atonic seizures (HP:0010819)4.38207707
6Epileptic encephalopathy (HP:0200134)4.07475656
7Hyperventilation (HP:0002883)4.04180846
8Abnormality of the corticospinal tract (HP:0002492)3.61780835
9Ankle clonus (HP:0011448)3.50174455
10Action tremor (HP:0002345)3.45996543
11Drooling (HP:0002307)3.43131468
12Urinary urgency (HP:0000012)3.36968484
13Degeneration of the lateral corticospinal tracts (HP:0002314)3.36644165
14Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.36644165
15Spastic gait (HP:0002064)3.34653518
16Generalized tonic-clonic seizures (HP:0002069)3.33899654
17Dialeptic seizures (HP:0011146)3.33359374
18Absence seizures (HP:0002121)3.25844484
19Progressive cerebellar ataxia (HP:0002073)3.24104537
20Polyphagia (HP:0002591)3.22382443
21Limb dystonia (HP:0002451)3.21782622
22Muscle fiber inclusion bodies (HP:0100299)3.21525027
23Excessive salivation (HP:0003781)3.20751944
24Nemaline bodies (HP:0003798)3.15286419
25Amyotrophic lateral sclerosis (HP:0007354)3.14899127
26Exercise-induced muscle cramps (HP:0003710)3.11325395
27Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.05928115
28Urinary bladder sphincter dysfunction (HP:0002839)3.03491323
29Abnormal eating behavior (HP:0100738)3.03013111
30Impaired vibration sensation in the lower limbs (HP:0002166)3.02487620
31Gait imbalance (HP:0002141)3.02044467
32Broad-based gait (HP:0002136)2.99499117
33Epileptiform EEG discharges (HP:0011182)2.95878407
34Lower limb muscle weakness (HP:0007340)2.94583602
35Supranuclear gaze palsy (HP:0000605)2.93432705
36Absent speech (HP:0001344)2.88434470
37EEG with generalized epileptiform discharges (HP:0011198)2.82754583
38Hemiparesis (HP:0001269)2.82085016
39Abnormality of binocular vision (HP:0011514)2.80057841
40Diplopia (HP:0000651)2.80057841
41Mutism (HP:0002300)2.71712165
42Hypsarrhythmia (HP:0002521)2.63311435
43Postural instability (HP:0002172)2.55893623
44Frequent falls (HP:0002359)2.54201192
45Papilledema (HP:0001085)2.51091704
46Fetal akinesia sequence (HP:0001989)2.50804900
47Truncal ataxia (HP:0002078)2.45184143
48Medial flaring of the eyebrow (HP:0010747)2.44492791
49Morphological abnormality of the pyramidal tract (HP:0002062)2.43260680
50Failure to thrive in infancy (HP:0001531)2.40613321
51Congenital primary aphakia (HP:0007707)2.40246341
52Genetic anticipation (HP:0003743)2.37758245
53Agitation (HP:0000713)2.35185158
54Specific learning disability (HP:0001328)2.35172017
55Rimmed vacuoles (HP:0003805)2.32791482
56Abnormality of the lower motor neuron (HP:0002366)2.30784963
57Type 1 muscle fiber predominance (HP:0003803)2.25733180
58Pheochromocytoma (HP:0002666)2.25347514
59Bundle branch block (HP:0011710)2.24773075
60Nephrogenic diabetes insipidus (HP:0009806)2.23804440
61Amblyopia (HP:0000646)2.23063367
62Impaired vibratory sensation (HP:0002495)2.22164303
63Scanning speech (HP:0002168)2.22137141
64Muscle hypertrophy of the lower extremities (HP:0008968)2.19821450
65Myotonia (HP:0002486)2.19741323
66Status epilepticus (HP:0002133)2.18881181
67Poor eye contact (HP:0000817)2.18508694
68Prolonged QT interval (HP:0001657)2.16332506
69Neurofibrillary tangles (HP:0002185)2.13763756
70Abnormal EKG (HP:0003115)2.12145792
71Spastic tetraplegia (HP:0002510)2.11834128
72Clonus (HP:0002169)2.10781013
73Akinesia (HP:0002304)2.10425178
74Intention tremor (HP:0002080)2.09332268
75Hemiplegia (HP:0002301)2.09033227
76Calf muscle hypertrophy (HP:0008981)2.08840076
77Dysdiadochokinesis (HP:0002075)2.02918794
78Inappropriate behavior (HP:0000719)2.01443937
79Muscle fiber splitting (HP:0003555)2.00571863
80Inability to walk (HP:0002540)1.99751388
81Exercise-induced myalgia (HP:0003738)1.99253316
82Rapidly progressive (HP:0003678)1.99010885
83Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.98800230
84Depression (HP:0000716)1.96148669
85Insidious onset (HP:0003587)1.95961789
86Termporal pattern (HP:0011008)1.95961789
87Gaze-evoked nystagmus (HP:0000640)1.94279491
88EMG: myopathic abnormalities (HP:0003458)1.92801225
89Abnormality of salivation (HP:0100755)1.92694648
90Peripheral hypomyelination (HP:0007182)1.92539459
91Hypoplasia of the corpus callosum (HP:0002079)1.92525540
92Abnormality of the calf musculature (HP:0001430)1.91830610
93Paraplegia (HP:0010550)1.91458017
94Abnormality of the musculature of the pelvis (HP:0001469)1.91254891
95Abnormality of the hip-girdle musculature (HP:0001445)1.91254891
96Torticollis (HP:0000473)1.91089763
97Dysmetria (HP:0001310)1.90474266
98Exotropia (HP:0000577)1.89371414
99Sudden death (HP:0001699)1.88055489
100Syncope (HP:0001279)1.85679281

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.14224246
2CASK4.02522631
3NTRK32.90640194
4MAP3K42.71497768
5EPHA42.64942118
6MAPK132.40358867
7DAPK22.40016202
8NTRK22.29861609
9PHKG12.24661508
10PHKG22.24661508
11PINK12.19495988
12OBSCN2.19174205
13PAK62.05723011
14UHMK11.95916624
15CAMKK21.94882390
16MAP2K71.93080138
17MAP4K21.88025153
18ERBB31.83754877
19BCR1.80189080
20PAK31.65198011
21PRKD31.54074494
22EPHA31.52112795
23MINK11.50965522
24WNK31.47002791
25MAP2K41.45627818
26CSNK1G21.36692130
27CAMKK11.36109865
28CDK51.26786249
29SIK21.20928641
30PLK21.20353966
31SGK4941.18779880
32SGK2231.18779880
33PRKCG1.15846837
34CAMK2B1.11169235
35SGK21.10230743
36CAMK2A1.07040911
37CSNK1G31.03170515
38DYRK1A1.00309759
39LIMK10.98456233
40KSR10.96171435
41CAMK10.95123083
42TNIK0.94652929
43PNCK0.94371227
44DYRK20.94358041
45FRK0.92756341
46CSNK1A1L0.90121171
47NTRK10.88977174
48PKN10.87159308
49MAPK120.86731656
50CDK190.85825775
51PRKCE0.83192457
52CAMK40.80025903
53CSNK1G10.79094922
54CAMK2G0.78517948
55GRK50.76575778
56MAP3K60.69589158
57MARK20.68909643
58MAP3K90.66608546
59CDK140.66333352
60CAMK2D0.64837062
61DYRK1B0.64036549
62SGK30.61188159
63CDK180.60273551
64DYRK30.60070047
65KSR20.59410134
66STK380.58762256
67CDK150.57153654
68BRD40.57041049
69TRIM280.56847901
70SGK10.56758103
71PRKG10.56692567
72STK110.53023863
73EPHB20.51349392
74CDK11A0.50433957
75ADRBK20.48852033
76PRKCZ0.47914183
77PRKACA0.44261990
78TAOK30.43555807
79RPS6KA30.43055001
80RET0.41723785
81PRKCH0.41592814
82PRKAA10.41249865
83CCNB10.40809160
84MAPK100.40053148
85OXSR10.38528658
86MAP3K120.36398516
87INSRR0.35989582
88MAPK70.35734965
89FYN0.35683555
90CSNK1D0.35586054
91ROCK20.35258139
92PRKACB0.33618052
93MAPK40.31981902
94TYRO30.31538125
95MAP3K50.29985883
96DAPK10.29964479
97FER0.26112275
98PTK2B0.25988727
99LATS20.25758979
100ROCK10.25675012

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.17578164
2Synaptic vesicle cycle_Homo sapiens_hsa047213.09791369
3GABAergic synapse_Homo sapiens_hsa047272.96091768
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.69497759
5Circadian entrainment_Homo sapiens_hsa047132.67639607
6Morphine addiction_Homo sapiens_hsa050322.53743026
7Amphetamine addiction_Homo sapiens_hsa050312.45789049
8Glutamatergic synapse_Homo sapiens_hsa047242.40454307
9Insulin secretion_Homo sapiens_hsa049112.19815356
10Dopaminergic synapse_Homo sapiens_hsa047282.17589638
11Cocaine addiction_Homo sapiens_hsa050302.04740187
12Long-term potentiation_Homo sapiens_hsa047202.00574246
13Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.86671822
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.75924295
15Cholinergic synapse_Homo sapiens_hsa047251.71708576
16Circadian rhythm_Homo sapiens_hsa047101.70195269
17Renin secretion_Homo sapiens_hsa049241.61913218
18Oxytocin signaling pathway_Homo sapiens_hsa049211.59362495
19Gastric acid secretion_Homo sapiens_hsa049711.56610760
20Taste transduction_Homo sapiens_hsa047421.51884857
21Salivary secretion_Homo sapiens_hsa049701.49882734
22Long-term depression_Homo sapiens_hsa047301.45517111
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.44935640
24Cardiac muscle contraction_Homo sapiens_hsa042601.44089175
25Collecting duct acid secretion_Homo sapiens_hsa049661.43368830
26Calcium signaling pathway_Homo sapiens_hsa040201.42916968
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42476274
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.36225260
29Serotonergic synapse_Homo sapiens_hsa047261.30461936
30cAMP signaling pathway_Homo sapiens_hsa040241.25730868
31Axon guidance_Homo sapiens_hsa043601.25459881
32Dilated cardiomyopathy_Homo sapiens_hsa054141.23552745
33Gap junction_Homo sapiens_hsa045401.18140731
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13828583
35Phototransduction_Homo sapiens_hsa047441.12066740
36cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11670514
37Type II diabetes mellitus_Homo sapiens_hsa049301.11515355
38Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.10459143
39Olfactory transduction_Homo sapiens_hsa047401.10088269
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08564398
41Regulation of autophagy_Homo sapiens_hsa041401.05827073
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.03977365
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.02729008
44Dorso-ventral axis formation_Homo sapiens_hsa043200.98611452
45Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97792021
46Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.95102316
47GnRH signaling pathway_Homo sapiens_hsa049120.91738811
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89465822
49Butanoate metabolism_Homo sapiens_hsa006500.89173840
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.87949075
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86130370
52Estrogen signaling pathway_Homo sapiens_hsa049150.84943254
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83365064
54Ras signaling pathway_Homo sapiens_hsa040140.78831478
55Vibrio cholerae infection_Homo sapiens_hsa051100.78016873
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77243899
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76311154
58Pancreatic secretion_Homo sapiens_hsa049720.72214053
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64807099
60MAPK signaling pathway_Homo sapiens_hsa040100.62743820
61Melanogenesis_Homo sapiens_hsa049160.60618216
62Oocyte meiosis_Homo sapiens_hsa041140.60066557
63Rap1 signaling pathway_Homo sapiens_hsa040150.59738669
64Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57685313
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.55948387
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.55198842
67Glucagon signaling pathway_Homo sapiens_hsa049220.54959276
68Inositol phosphate metabolism_Homo sapiens_hsa005620.54548581
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53485203
70ErbB signaling pathway_Homo sapiens_hsa040120.53286787
71Alzheimers disease_Homo sapiens_hsa050100.52616160
72AMPK signaling pathway_Homo sapiens_hsa041520.50705823
73Glioma_Homo sapiens_hsa052140.48191504
74Phagosome_Homo sapiens_hsa041450.48144774
75mTOR signaling pathway_Homo sapiens_hsa041500.45023636
76Thyroid hormone synthesis_Homo sapiens_hsa049180.43374518
77Endocytosis_Homo sapiens_hsa041440.42219129
78Alcoholism_Homo sapiens_hsa050340.42009954
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41580837
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40863683
81Insulin signaling pathway_Homo sapiens_hsa049100.40346663
82Ovarian steroidogenesis_Homo sapiens_hsa049130.38646962
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36573350
84Choline metabolism in cancer_Homo sapiens_hsa052310.35749272
85beta-Alanine metabolism_Homo sapiens_hsa004100.34501282
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.33871503
87Oxidative phosphorylation_Homo sapiens_hsa001900.31226782
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31046006
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30962806
90ABC transporters_Homo sapiens_hsa020100.30644871
91Parkinsons disease_Homo sapiens_hsa050120.29876266
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29807409
93Renal cell carcinoma_Homo sapiens_hsa052110.29340319
94Prolactin signaling pathway_Homo sapiens_hsa049170.26381909
95VEGF signaling pathway_Homo sapiens_hsa043700.25566759
96Salmonella infection_Homo sapiens_hsa051320.25276325
97Chemokine signaling pathway_Homo sapiens_hsa040620.23865845
98Bile secretion_Homo sapiens_hsa049760.23515455
99Nitrogen metabolism_Homo sapiens_hsa009100.23439865
100Ether lipid metabolism_Homo sapiens_hsa005650.22641142

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