ZNF230

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033394.63559106
2positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)4.60632797
3regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)4.60632797
4regulation of interleukin-12 biosynthetic process (GO:0045075)4.59735719
5regulation of MHC class II biosynthetic process (GO:0045346)4.43694889
6fucose catabolic process (GO:0019317)4.09315168
7L-fucose metabolic process (GO:0042354)4.09315168
8L-fucose catabolic process (GO:0042355)4.09315168
9regulation of isotype switching to IgG isotypes (GO:0048302)3.87982057
10negative regulation of interleukin-17 production (GO:0032700)3.72618184
11negative regulation of DNA-dependent DNA replication (GO:2000104)3.67017736
12kynurenine metabolic process (GO:0070189)3.57594530
13tryptophan catabolic process (GO:0006569)3.54030922
14indole-containing compound catabolic process (GO:0042436)3.54030922
15indolalkylamine catabolic process (GO:0046218)3.54030922
16response to pheromone (GO:0019236)3.52406056
17regulation of interleukin-6 biosynthetic process (GO:0045408)3.50297151
18DNA double-strand break processing (GO:0000729)3.46720085
19neural tube formation (GO:0001841)3.45959101
20regulation of vitamin D biosynthetic process (GO:0060556)3.34534870
21positive regulation of DNA recombination (GO:0045911)3.33853365
22positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.29675169
23mannosylation (GO:0097502)3.24416969
24negative regulation of neurological system process (GO:0031645)3.23047911
25mitochondrial respiratory chain complex I assembly (GO:0032981)3.21350886
26NADH dehydrogenase complex assembly (GO:0010257)3.21350886
27mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.21350886
28positive regulation of interleukin-1 beta secretion (GO:0050718)3.20128535
29replication fork processing (GO:0031297)3.17881939
30positive regulation of chemokine biosynthetic process (GO:0045080)3.12474439
31preassembly of GPI anchor in ER membrane (GO:0016254)3.11704160
32tryptophan metabolic process (GO:0006568)3.11477823
33cullin deneddylation (GO:0010388)3.11217590
34respiratory chain complex IV assembly (GO:0008535)3.10762613
35modulation of growth of symbiont involved in interaction with host (GO:0044144)3.05183726
36regulation of growth of symbiont in host (GO:0044126)3.05183726
37negative regulation of growth of symbiont in host (GO:0044130)3.05183726
38negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.05183726
39protein complex biogenesis (GO:0070271)3.05102181
40indolalkylamine metabolic process (GO:0006586)3.03502151
41defense response to protozoan (GO:0042832)3.01789105
42positive regulation of isotype switching (GO:0045830)3.01324389
43DNA deamination (GO:0045006)3.00651506
44regulation of podosome assembly (GO:0071801)3.00119976
45regulation of interleukin-1 beta secretion (GO:0050706)3.00070404
46somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.99990685
47isotype switching (GO:0045190)2.99990685
48somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.99990685
49positive regulation of interleukin-1 secretion (GO:0050716)2.99730469
50regulation of memory T cell differentiation (GO:0043380)2.99407187
51peptidyl-histidine modification (GO:0018202)2.98516750
52mitochondrial respiratory chain complex assembly (GO:0033108)2.93477182
53protein deneddylation (GO:0000338)2.91534486
54behavioral response to nicotine (GO:0035095)2.91300293
55regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.91283458
56regulation of mitotic spindle checkpoint (GO:1903504)2.91283458
57cellular response to interleukin-15 (GO:0071350)2.88615609
58ubiquinone biosynthetic process (GO:0006744)2.88097449
59platelet dense granule organization (GO:0060155)2.87401159
60epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.84068881
61water-soluble vitamin biosynthetic process (GO:0042364)2.81543194
62maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.80791583
63regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.80501621
64positive regulation of interleukin-12 production (GO:0032735)2.77922235
65epithelial cilium movement (GO:0003351)2.74468650
66protein K6-linked ubiquitination (GO:0085020)2.72832992
67regulation of nuclear cell cycle DNA replication (GO:0033262)2.71913080
68piRNA metabolic process (GO:0034587)2.71068775
69negative regulation of metanephros development (GO:0072217)2.71022554
70detection of light stimulus involved in sensory perception (GO:0050962)2.70990093
71detection of light stimulus involved in visual perception (GO:0050908)2.70990093
72regulation of interleukin-17 production (GO:0032660)2.68237197
73regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.67069374
74retinal cone cell development (GO:0046549)2.66649595
75adaptation of signaling pathway (GO:0023058)2.63905134
76cytochrome complex assembly (GO:0017004)2.62871378
77cellular ketone body metabolic process (GO:0046950)2.62731865
78regulation of smooth muscle cell apoptotic process (GO:0034391)2.62280096
79ubiquinone metabolic process (GO:0006743)2.61703581
80nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.60318916
81regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.59765527
82photoreceptor cell maintenance (GO:0045494)2.59265107
83detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.59211722
84positive regulation of osteoclast differentiation (GO:0045672)2.59144531
85positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.59024350
86response to protozoan (GO:0001562)2.58616254
87regulation of meiosis I (GO:0060631)2.57980649
88axoneme assembly (GO:0035082)2.57323109
89amine catabolic process (GO:0009310)2.57303135
90cellular biogenic amine catabolic process (GO:0042402)2.57303135
91recombinational repair (GO:0000725)2.57086122
92negative regulation of DNA recombination (GO:0045910)2.54972293
93RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.54377854
94protein-cofactor linkage (GO:0018065)2.53396006
95double-strand break repair via homologous recombination (GO:0000724)2.52824396
96GPI anchor metabolic process (GO:0006505)2.51231178
97positive regulation of organelle assembly (GO:1902117)2.50579639
98ketone body metabolic process (GO:1902224)2.49921750
99T cell differentiation involved in immune response (GO:0002292)2.49752060
100alpha-beta T cell activation involved in immune response (GO:0002287)2.49752060

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.01947341
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.02421995
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.98135120
4NOTCH1_21737748_ChIP-Seq_TLL_Human2.78924517
5EST1_17652178_ChIP-ChIP_JURKAT_Human2.69811173
6* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.69511154
7VDR_22108803_ChIP-Seq_LS180_Human2.49708161
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.42586434
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.35963211
10IGF1R_20145208_ChIP-Seq_DFB_Human2.31312888
11VDR_23849224_ChIP-Seq_CD4+_Human2.27662240
12* ELK1_19687146_ChIP-ChIP_HELA_Human2.20895929
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.19390138
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.16863027
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14381338
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.09248393
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.08894505
18FUS_26573619_Chip-Seq_HEK293_Human2.08353592
19EWS_26573619_Chip-Seq_HEK293_Human2.07734708
20TAF15_26573619_Chip-Seq_HEK293_Human1.82708442
21* ETS1_20019798_ChIP-Seq_JURKAT_Human1.82476839
22SALL1_21062744_ChIP-ChIP_HESCs_Human1.82090446
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80916289
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75109563
25GBX2_23144817_ChIP-Seq_PC3_Human1.74415327
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.73686747
27FOXP3_21729870_ChIP-Seq_TREG_Human1.72763659
28BP1_19119308_ChIP-ChIP_Hs578T_Human1.71008941
29IRF8_21731497_ChIP-ChIP_J774_Mouse1.69470248
30IRF1_19129219_ChIP-ChIP_H3396_Human1.64053642
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62650278
32TP53_22573176_ChIP-Seq_HFKS_Human1.60560014
33P300_19829295_ChIP-Seq_ESCs_Human1.59945667
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52382773
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50515498
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.49410269
37ER_23166858_ChIP-Seq_MCF-7_Human1.48214202
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47924510
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.47672347
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45646531
41* MYC_18940864_ChIP-ChIP_HL60_Human1.44444102
42IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.43870768
43* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43789889
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42452301
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41162816
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35116840
47BCAT_22108803_ChIP-Seq_LS180_Human1.34871576
48CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.32527570
49E2F4_17652178_ChIP-ChIP_JURKAT_Human1.32236397
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.31884691
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31763157
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31395770
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31341604
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30126072
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.30021897
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.29162285
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29162285
58ETV2_25802403_ChIP-Seq_MESCs_Mouse1.27284440
59CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.23926615
60GATA3_26560356_Chip-Seq_TH2_Human1.23177703
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21594838
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20268726
63CBP_20019798_ChIP-Seq_JUKART_Human1.20268726
64SOX2_19829295_ChIP-Seq_ESCs_Human1.20190779
65NANOG_19829295_ChIP-Seq_ESCs_Human1.20190779
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16760049
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16760049
68SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.16327621
69* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.15561120
70AR_20517297_ChIP-Seq_VCAP_Human1.11209151
71CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10978618
72CRX_20693478_ChIP-Seq_RETINA_Mouse1.10833382
73STAT3_23295773_ChIP-Seq_U87_Human1.10351033
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09859694
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09355266
76NCOR_22424771_ChIP-Seq_293T_Human1.07498369
77FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07472984
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07057755
79GABP_19822575_ChIP-Seq_HepG2_Human1.06547991
80KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04566097
81SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03243063
82TCF4_23295773_ChIP-Seq_U87_Human1.02654089
83BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01947235
84EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00957430
85CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.00558766
86TCF4_22108803_ChIP-Seq_LS180_Human1.00204703
87GATA3_21878914_ChIP-Seq_MCF-7_Human0.99593456
88EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99280562
89DCP1A_22483619_ChIP-Seq_HELA_Human0.99272155
90AR_25329375_ChIP-Seq_VCAP_Human0.99027060
91FLI1_21867929_ChIP-Seq_TH2_Mouse0.97861883
92OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97073319
93PRDM14_20953172_ChIP-Seq_ESCs_Human0.96888281
94STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.96857861
95HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96637804
96RBPJ_22232070_ChIP-Seq_NCS_Mouse0.96459723
97GATA3_26560356_Chip-Seq_TH1_Human0.95362531
98AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93736376
99FOXH1_21741376_ChIP-Seq_EPCs_Human0.93059525
100SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.92973014

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.67887049
2MP0008877_abnormal_DNA_methylation3.01554727
3MP0005671_abnormal_response_to2.93869990
4MP0003195_calcinosis2.91477428
5MP0000569_abnormal_digit_pigmentation2.90970797
6MP0003724_increased_susceptibility_to2.35430907
7MP0001873_stomach_inflammation2.34483066
8MP0000372_irregular_coat_pigmentation2.26149596
9MP0008058_abnormal_DNA_repair2.25326002
10MP0002102_abnormal_ear_morphology2.13683813
11MP0003787_abnormal_imprinting2.04538628
12MP0009785_altered_susceptibility_to2.03874630
13MP0003646_muscle_fatigue2.00758162
14MP0001986_abnormal_taste_sensitivity1.99535702
15MP0005551_abnormal_eye_electrophysiolog1.93692183
16MP0002653_abnormal_ependyma_morphology1.89047252
17MP0006072_abnormal_retinal_apoptosis1.86697933
18MP0002148_abnormal_hypersensitivity_rea1.74898716
19MP0004142_abnormal_muscle_tone1.73332930
20MP0001800_abnormal_humoral_immune1.73318772
21MP0005174_abnormal_tail_pigmentation1.70158188
22MP0004782_abnormal_surfactant_physiolog1.67054932
23MP0005253_abnormal_eye_physiology1.65320183
24MP0000015_abnormal_ear_pigmentation1.55001319
25MP0003011_delayed_dark_adaptation1.54837868
26MP0010307_abnormal_tumor_latency1.53599176
27MP0006035_abnormal_mitochondrial_morpho1.51075787
28MP0005075_abnormal_melanosome_morpholog1.50372879
29MP0002405_respiratory_system_inflammati1.49686110
30MP0005387_immune_system_phenotype1.49179478
31MP0001790_abnormal_immune_system1.49179478
32MP0009764_decreased_sensitivity_to1.46511157
33MP0002638_abnormal_pupillary_reflex1.43923819
34MP0008875_abnormal_xenobiotic_pharmacok1.43777926
35MP0001529_abnormal_vocalization1.41348828
36MP0003880_abnormal_central_pattern1.40808295
37MP0005000_abnormal_immune_tolerance1.36972062
38MP0003186_abnormal_redox_activity1.34355655
39MP0000427_abnormal_hair_cycle1.33438098
40MP0002723_abnormal_immune_serum1.30145642
41MP0000685_abnormal_immune_system1.29701826
42MP0001968_abnormal_touch/_nociception1.28693626
43MP0008872_abnormal_physiological_respon1.28203530
44MP0003436_decreased_susceptibility_to1.27849603
45MP0008057_abnormal_DNA_replication1.25422868
46MP0009333_abnormal_splenocyte_physiolog1.21713861
47MP0005084_abnormal_gallbladder_morpholo1.18737850
48MP0010094_abnormal_chromosome_stability1.18444036
49MP0002277_abnormal_respiratory_mucosa1.17537748
50MP0002095_abnormal_skin_pigmentation1.15428569
51MP0001324_abnormal_eye_pigmentation1.15130029
52MP0009046_muscle_twitch1.13299840
53MP0002452_abnormal_antigen_presenting1.12753595
54MP0002837_dystrophic_cardiac_calcinosis1.11753524
55MP0002420_abnormal_adaptive_immunity1.10971450
56MP0002163_abnormal_gland_morphology1.10115194
57MP0001819_abnormal_immune_cell1.09687095
58MP0002928_abnormal_bile_duct1.09455811
59MP0005310_abnormal_salivary_gland1.09054490
60MP0001984_abnormal_olfaction1.08048520
61MP0009697_abnormal_copulation1.05726288
62MP0003121_genomic_imprinting1.01551799
63MP0000689_abnormal_spleen_morphology0.98632652
64MP0002419_abnormal_innate_immunity0.98248213
65MP0006276_abnormal_autonomic_nervous0.97386418
66MP0006036_abnormal_mitochondrial_physio0.97142379
67MP0009745_abnormal_behavioral_response0.95161226
68MP0005389_reproductive_system_phenotype0.92938978
69MP0000383_abnormal_hair_follicle0.90319344
70MP0001919_abnormal_reproductive_system0.89918222
71MP0005410_abnormal_fertilization0.88687902
72MP0003252_abnormal_bile_duct0.88294632
73MP0005025_abnormal_response_to0.88273504
74MP0002693_abnormal_pancreas_physiology0.87762989
75MP0005645_abnormal_hypothalamus_physiol0.87193839
76MP0002751_abnormal_autonomic_nervous0.85223437
77MP0003136_yellow_coat_color0.84838597
78MP0001905_abnormal_dopamine_level0.84394341
79MP0002272_abnormal_nervous_system0.83772140
80MP0001845_abnormal_inflammatory_respons0.82598089
81MP0001485_abnormal_pinna_reflex0.81855482
82MP0005085_abnormal_gallbladder_physiolo0.80921523
83MP0001929_abnormal_gametogenesis0.80874912
84MP0001119_abnormal_female_reproductive0.80560648
85MP0001764_abnormal_homeostasis0.78162111
86MP0002722_abnormal_immune_system0.77788070
87MP0002210_abnormal_sex_determination0.77178557
88MP0004043_abnormal_pH_regulation0.76443515
89MP0001663_abnormal_digestive_system0.75124052
90MP0000716_abnormal_immune_system0.74968830
91MP0008789_abnormal_olfactory_epithelium0.74621523
92MP0008995_early_reproductive_senescence0.73206757
93MP0004924_abnormal_behavior0.73157165
94MP0005386_behavior/neurological_phenoty0.73157165
95MP0002876_abnormal_thyroid_physiology0.72801521
96MP0003878_abnormal_ear_physiology0.72474333
97MP0005377_hearing/vestibular/ear_phenot0.72474333
98MP0000653_abnormal_sex_gland0.72404673
99MP0003698_abnormal_male_reproductive0.71850202
100MP0001486_abnormal_startle_reflex0.69906646

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.32669791
2Stomatitis (HP:0010280)3.82371091
3Pancreatic fibrosis (HP:0100732)3.61021946
4True hermaphroditism (HP:0010459)3.49211852
5Nephronophthisis (HP:0000090)3.26241813
6Congenital stationary night blindness (HP:0007642)3.17443467
7Absent rod-and cone-mediated responses on ERG (HP:0007688)3.06332230
8Abnormal rod and cone electroretinograms (HP:0008323)3.05361325
9Attenuation of retinal blood vessels (HP:0007843)3.02206039
10Abnormality of midbrain morphology (HP:0002418)3.01114622
11Molar tooth sign on MRI (HP:0002419)3.01114622
12Medial flaring of the eyebrow (HP:0010747)2.83304525
13Hepatocellular necrosis (HP:0001404)2.81214111
14Mitochondrial inheritance (HP:0001427)2.75899924
15Increased CSF lactate (HP:0002490)2.68924128
16Abnormality of the renal cortex (HP:0011035)2.68141283
17Bile duct proliferation (HP:0001408)2.65578109
18Abnormal biliary tract physiology (HP:0012439)2.65578109
19Acute necrotizing encephalopathy (HP:0006965)2.64130430
20Abnormality of the renal medulla (HP:0100957)2.62882873
21Hepatic necrosis (HP:0002605)2.55414732
22Acute encephalopathy (HP:0006846)2.49890530
23Retrobulbar optic neuritis (HP:0100654)2.49707250
24Optic neuritis (HP:0100653)2.49707250
25Chromosomal breakage induced by crosslinking agents (HP:0003221)2.47731198
26Progressive macrocephaly (HP:0004481)2.46878596
27Chromsome breakage (HP:0040012)2.44220889
28Progressive inability to walk (HP:0002505)2.35873048
29Abnormal mitochondria in muscle tissue (HP:0008316)2.32484734
30Type II lissencephaly (HP:0007260)2.30600640
31Chronic hepatic failure (HP:0100626)2.30401652
323-Methylglutaconic aciduria (HP:0003535)2.27109793
33Abnormality of chromosome stability (HP:0003220)2.26130683
34Cystic liver disease (HP:0006706)2.25395482
35Polydipsia (HP:0001959)2.23632428
36Abnormal drinking behavior (HP:0030082)2.23632428
37Renal cortical cysts (HP:0000803)2.23060714
38Lipid accumulation in hepatocytes (HP:0006561)2.22364797
39Optic disc pallor (HP:0000543)2.16079373
40Tubular atrophy (HP:0000092)2.13791651
41IgG deficiency (HP:0004315)2.11895388
42Increased hepatocellular lipid droplets (HP:0006565)2.11020818
43Nephrogenic diabetes insipidus (HP:0009806)2.10777313
44Sclerocornea (HP:0000647)2.10010824
45Aplasia/Hypoplasia of the uvula (HP:0010293)2.09148452
46Congenital hepatic fibrosis (HP:0002612)2.06918956
47Gait imbalance (HP:0002141)2.06401313
48Congenital primary aphakia (HP:0007707)2.05761237
49Inability to walk (HP:0002540)2.05682302
50Abnormality of the ileum (HP:0001549)2.01673445
51Neoplasm of the adrenal cortex (HP:0100641)2.01460173
52Increased serum lactate (HP:0002151)2.00909561
53Abolished electroretinogram (ERG) (HP:0000550)2.00501561
54Pendular nystagmus (HP:0012043)2.00373467
55Duplicated collecting system (HP:0000081)1.99329317
56Congenital, generalized hypertrichosis (HP:0004540)1.98873250
57Thyroiditis (HP:0100646)1.98069873
58Lissencephaly (HP:0001339)1.98020724
59Methylmalonic acidemia (HP:0002912)1.95044071
60Orchitis (HP:0100796)1.94912686
61Meckel diverticulum (HP:0002245)1.94524361
62Hypochromic microcytic anemia (HP:0004840)1.94472783
63Abnormality of the renal collecting system (HP:0004742)1.94050602
64Fair hair (HP:0002286)1.93781196
65Abnormality of the pons (HP:0007361)1.92805821
66Abnormality of B cell number (HP:0010975)1.92423559
67Aplasia/Hypoplasia of the tongue (HP:0010295)1.92340533
68Anencephaly (HP:0002323)1.91793674
69Type 2 muscle fiber atrophy (HP:0003554)1.91613436
70Decreased central vision (HP:0007663)1.91261180
71Abnormal respiratory motile cilium morphology (HP:0005938)1.87921467
72Abnormal respiratory epithelium morphology (HP:0012253)1.87921467
73Abnormality of DNA repair (HP:0003254)1.87766818
74Colon cancer (HP:0003003)1.87117276
75Renal Fanconi syndrome (HP:0001994)1.86039390
76Elevated erythrocyte sedimentation rate (HP:0003565)1.83574829
77Abnormal delayed hypersensitivity skin test (HP:0002963)1.82840110
78Myositis (HP:0100614)1.82620521
79Hyperventilation (HP:0002883)1.82564149
80Hypothermia (HP:0002045)1.82172083
81Abnormal protein N-linked glycosylation (HP:0012347)1.79964097
82Abnormal protein glycosylation (HP:0012346)1.79964097
83Abnormal glycosylation (HP:0012345)1.79964097
84Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.79964097
85Decreased electroretinogram (ERG) amplitude (HP:0000654)1.79156909
86Polyuria (HP:0000103)1.78272756
87Furrowed tongue (HP:0000221)1.78190930
88Methylmalonic aciduria (HP:0012120)1.77930918
89Stomach cancer (HP:0012126)1.77911169
90Hyperglycinemia (HP:0002154)1.77501066
91Cerebellar dysplasia (HP:0007033)1.77433830
92Absent/shortened dynein arms (HP:0200106)1.77365508
93Dynein arm defect of respiratory motile cilia (HP:0012255)1.77365508
94Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.77104078
95Abnormality of alanine metabolism (HP:0010916)1.77104078
96Hyperalaninemia (HP:0003348)1.77104078
97Constricted visual fields (HP:0001133)1.76758686
98Abnormality of T cell physiology (HP:0011840)1.76452719
99Keratoconjunctivitis (HP:0001096)1.76320185
100Carpal bone hypoplasia (HP:0001498)1.75076875

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.92916106
2TXK3.26003499
3ZAK2.67783808
4BMPR1B2.63964677
5MAP4K22.63040803
6EIF2AK32.53439215
7TRIM282.52580919
8ADRBK22.52255410
9ACVR1B2.22097742
10GRK11.67384840
11NME11.60378341
12WNK31.59674870
13NUAK11.57771254
14CASK1.56788438
15MAP3K41.55319441
16SRPK11.43452426
17ERBB31.42318173
18TAOK31.41697466
19TLK11.41575965
20PINK11.35261316
21MST41.30952757
22CAMKK21.30821673
23MKNK21.30517081
24MAPK131.28202903
25PLK21.25960339
26OXSR11.23820959
27TNIK1.23521830
28BCKDK1.23216823
29FLT31.21399976
30TNK21.19083430
31WNK41.10284199
32BRSK21.09986651
33EIF2AK11.09786446
34MAP2K71.08543679
35KIT1.08484138
36PLK41.08013014
37PLK31.04957190
38BCR0.99568621
39ADRBK10.97512273
40PAK30.90256526
41DYRK30.89933508
42MARK30.87185852
43TTK0.85409604
44MAP2K60.85086806
45PRKCQ0.84485247
46PTK2B0.81455065
47PIK3CG0.80153463
48BLK0.79943131
49IKBKB0.79687411
50IRAK40.77213580
51CDK190.76829412
52SIK30.76180342
53SYK0.73431043
54DAPK20.73348609
55INSRR0.72587993
56EIF2AK20.71682480
57DYRK20.69860857
58STK160.69249061
59MAP4K10.67959232
60VRK10.67629549
61PRKCE0.67046686
62IKBKE0.66836155
63PLK10.66071952
64CSNK1G10.65246296
65MKNK10.64687606
66CSNK1G20.64574546
67IRAK10.64329890
68LYN0.64088912
69TEC0.63638133
70ATR0.61517669
71SIK20.61117987
72TSSK60.60486340
73CSNK1G30.60314823
74CSNK1A1L0.58975378
75JAK30.56532926
76MATK0.53732581
77MAP2K40.52657572
78STK30.51945548
79EPHA30.51695490
80WEE10.51528991
81NLK0.48722408
82STK110.48367333
83STK390.48222715
84PRKCG0.45871811
85MAP3K50.45124789
86NEK10.43976631
87LCK0.42863354
88CHUK0.42560291
89JAK20.41681849
90RPS6KA40.41252024
91HCK0.40593572
92GRK60.40006240
93CSF1R0.38982477
94RIPK40.38604271
95FES0.37903948
96BUB10.37370117
97CHEK20.36382201
98ATM0.36074781
99RPS6KA50.35252219
100PDK20.35059902

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030502.76579576
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.66849780
3Protein export_Homo sapiens_hsa030602.64729946
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.60816341
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.55301524
6Non-homologous end-joining_Homo sapiens_hsa034502.49823156
7RNA polymerase_Homo sapiens_hsa030202.48132156
8Regulation of autophagy_Homo sapiens_hsa041402.40023634
9Homologous recombination_Homo sapiens_hsa034402.25819870
10Allograft rejection_Homo sapiens_hsa053302.18416044
11Fanconi anemia pathway_Homo sapiens_hsa034602.18235546
12Phototransduction_Homo sapiens_hsa047442.08077860
13Basal transcription factors_Homo sapiens_hsa030222.04725063
14Caffeine metabolism_Homo sapiens_hsa002321.89705044
15Graft-versus-host disease_Homo sapiens_hsa053321.86772731
16Type I diabetes mellitus_Homo sapiens_hsa049401.82256371
17Oxidative phosphorylation_Homo sapiens_hsa001901.74556966
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.74398585
19Butanoate metabolism_Homo sapiens_hsa006501.72276185
20Primary immunodeficiency_Homo sapiens_hsa053401.67769038
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.64921567
22Nitrogen metabolism_Homo sapiens_hsa009101.62759141
23Rheumatoid arthritis_Homo sapiens_hsa053231.58347526
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.56769171
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.56044702
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.55699355
27Propanoate metabolism_Homo sapiens_hsa006401.51475801
28Linoleic acid metabolism_Homo sapiens_hsa005911.44210267
29Parkinsons disease_Homo sapiens_hsa050121.43422839
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.42520139
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.42317188
32Autoimmune thyroid disease_Homo sapiens_hsa053201.35896171
33RNA degradation_Homo sapiens_hsa030181.32202231
34African trypanosomiasis_Homo sapiens_hsa051431.30423729
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.26280713
36Tryptophan metabolism_Homo sapiens_hsa003801.21829278
37Asthma_Homo sapiens_hsa053101.20869122
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20851002
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14988316
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13438659
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.13301821
42Selenocompound metabolism_Homo sapiens_hsa004501.09953239
43NOD-like receptor signaling pathway_Homo sapiens_hsa046211.05569410
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.03577740
45Antigen processing and presentation_Homo sapiens_hsa046120.99553371
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97874441
47Huntingtons disease_Homo sapiens_hsa050160.96588607
48Pyrimidine metabolism_Homo sapiens_hsa002400.94679548
49Peroxisome_Homo sapiens_hsa041460.91725676
50Ether lipid metabolism_Homo sapiens_hsa005650.91671460
51Olfactory transduction_Homo sapiens_hsa047400.90126457
52T cell receptor signaling pathway_Homo sapiens_hsa046600.89906941
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89735642
54Hematopoietic cell lineage_Homo sapiens_hsa046400.88493110
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88270956
56Purine metabolism_Homo sapiens_hsa002300.87026016
57One carbon pool by folate_Homo sapiens_hsa006700.85946287
58RNA transport_Homo sapiens_hsa030130.84938828
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84657303
60Leishmaniasis_Homo sapiens_hsa051400.82626230
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81609152
62Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.80811699
63Measles_Homo sapiens_hsa051620.80312838
64Base excision repair_Homo sapiens_hsa034100.77113672
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74736485
66Legionellosis_Homo sapiens_hsa051340.72923037
67Malaria_Homo sapiens_hsa051440.72744343
68Tuberculosis_Homo sapiens_hsa051520.69609219
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.68935256
70Mismatch repair_Homo sapiens_hsa034300.68670137
71Collecting duct acid secretion_Homo sapiens_hsa049660.67671388
72Alzheimers disease_Homo sapiens_hsa050100.66021452
73Nicotine addiction_Homo sapiens_hsa050330.65255651
74Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.64078633
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61926267
76Herpes simplex infection_Homo sapiens_hsa051680.61835687
77Epstein-Barr virus infection_Homo sapiens_hsa051690.61681415
78Arachidonic acid metabolism_Homo sapiens_hsa005900.58948866
79ABC transporters_Homo sapiens_hsa020100.56437302
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.56014884
81Taste transduction_Homo sapiens_hsa047420.53661463
82Chemical carcinogenesis_Homo sapiens_hsa052040.53462701
83Steroid biosynthesis_Homo sapiens_hsa001000.49011813
84Systemic lupus erythematosus_Homo sapiens_hsa053220.48404824
85Spliceosome_Homo sapiens_hsa030400.46880603
86Nucleotide excision repair_Homo sapiens_hsa034200.45750276
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.45298549
88Metabolic pathways_Homo sapiens_hsa011000.44902646
89Staphylococcus aureus infection_Homo sapiens_hsa051500.44227787
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.44032995
91Morphine addiction_Homo sapiens_hsa050320.42225854
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.40038592
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38972173
94Osteoclast differentiation_Homo sapiens_hsa043800.38919749
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36349851
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34645628
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.32916749
98TNF signaling pathway_Homo sapiens_hsa046680.31654864
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31059773
100Glycerolipid metabolism_Homo sapiens_hsa005610.25674448

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