ZNF229

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lactate metabolic process (GO:0006089)4.00921647
2presynaptic membrane assembly (GO:0097105)3.78612014
3negative regulation of cytosolic calcium ion concentration (GO:0051481)3.17720845
4pyrimidine nucleobase catabolic process (GO:0006208)3.10262341
5presynaptic membrane organization (GO:0097090)3.09232157
6axonal fasciculation (GO:0007413)3.09015148
7neuron recognition (GO:0008038)3.08549948
8nonmotile primary cilium assembly (GO:0035058)3.01060417
9paraxial mesoderm development (GO:0048339)2.68153409
10negative regulation of gluconeogenesis (GO:0045721)2.65840058
11negative chemotaxis (GO:0050919)2.61689491
12cochlea development (GO:0090102)2.59415985
13postsynaptic membrane organization (GO:0001941)2.55553924
14cellular response to leptin stimulus (GO:0044320)2.53721667
15smooth muscle tissue development (GO:0048745)2.52436764
16neurotransmitter-gated ion channel clustering (GO:0072578)2.50575561
17regulation of acrosome reaction (GO:0060046)2.48107086
18establishment of planar polarity (GO:0001736)2.44579417
19establishment of tissue polarity (GO:0007164)2.44579417
20regulation of axon guidance (GO:1902667)2.43629425
21embryonic body morphogenesis (GO:0010172)2.43518170
22neuron cell-cell adhesion (GO:0007158)2.38066738
23auditory behavior (GO:0031223)2.36714930
24polarized epithelial cell differentiation (GO:0030859)2.36576491
25peristalsis (GO:0030432)2.36317637
26apical protein localization (GO:0045176)2.32784518
27regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.31746227
28positive regulation of glycolytic process (GO:0045821)2.31545555
29positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.31451432
30calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.31414130
31retinal cone cell development (GO:0046549)2.31076482
32ephrin receptor signaling pathway (GO:0048013)2.31048858
33cerebral cortex radially oriented cell migration (GO:0021799)2.28204006
34negative regulation of axon guidance (GO:1902668)2.27468229
35regulation of axon extension involved in axon guidance (GO:0048841)2.27307892
36central nervous system neuron axonogenesis (GO:0021955)2.25423882
37nucleobase catabolic process (GO:0046113)2.22350064
38positive regulation of synapse assembly (GO:0051965)2.16277192
39mechanosensory behavior (GO:0007638)2.15271681
40intraciliary transport (GO:0042073)2.13741837
41piRNA metabolic process (GO:0034587)2.13022395
42central nervous system projection neuron axonogenesis (GO:0021952)2.11912897
43negative regulation of keratinocyte proliferation (GO:0010839)2.09898266
44dendritic spine morphogenesis (GO:0060997)2.08888458
45body morphogenesis (GO:0010171)2.08294945
46neural tube formation (GO:0001841)2.08265503
47limb bud formation (GO:0060174)2.07602974
48artery development (GO:0060840)2.07252045
49negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.05633814
50regulation of transforming growth factor beta2 production (GO:0032909)2.04930318
51response to leptin (GO:0044321)2.04641459
52cerebral cortex cell migration (GO:0021795)2.04312309
53protein localization to synapse (GO:0035418)2.04240591
54epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.04226776
55hippo signaling (GO:0035329)2.03999981
56brain morphogenesis (GO:0048854)2.02599438
57asymmetric protein localization (GO:0008105)2.01208665
58establishment of nucleus localization (GO:0040023)2.00359344
59DNA methylation involved in gamete generation (GO:0043046)2.00337978
60righting reflex (GO:0060013)1.99603194
61lymphangiogenesis (GO:0001946)1.98338134
62cerebral cortex development (GO:0021987)1.98192132
63regulation of DNA methylation (GO:0044030)1.97758752
64negative regulation of axon extension involved in axon guidance (GO:0048843)1.96674297
65histone H2A acetylation (GO:0043968)1.96435955
66cilium morphogenesis (GO:0060271)1.96184415
67axon extension involved in axon guidance (GO:0048846)1.95194479
68neuron projection extension involved in neuron projection guidance (GO:1902284)1.95194479
69retinal ganglion cell axon guidance (GO:0031290)1.94642975
70multicellular organism reproduction (GO:0032504)1.94511131
71regulation of respiratory system process (GO:0044065)1.93841682
72synapse assembly (GO:0007416)1.93437382
73maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)1.91499335
74bone trabecula formation (GO:0060346)1.91437300
75cellular response to cholesterol (GO:0071397)1.90827030
76hindbrain development (GO:0030902)1.90808350
77urinary tract smooth muscle contraction (GO:0014848)1.89674230
78startle response (GO:0001964)1.89237009
79somite rostral/caudal axis specification (GO:0032525)1.89212345
80spinal cord development (GO:0021510)1.88881458
81retina layer formation (GO:0010842)1.88785507
82axon extension (GO:0048675)1.88643100
83regulation of short-term neuronal synaptic plasticity (GO:0048172)1.88016308
84cytoplasmic mRNA processing body assembly (GO:0033962)1.87659090
85dendrite morphogenesis (GO:0048813)1.87574205
86positive regulation of gastrulation (GO:2000543)1.86002056
87positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)1.84704186
88positive regulation of cell cycle G2/M phase transition (GO:1902751)1.84704186
89regulation of meiosis I (GO:0060631)1.82485338
90coenzyme catabolic process (GO:0009109)1.82467526
91chondrocyte proliferation (GO:0035988)1.81584826
92positive regulation of meiosis (GO:0045836)1.81541318
93glutamine metabolic process (GO:0006541)1.80921388
94lens morphogenesis in camera-type eye (GO:0002089)1.80865529
95positive regulation of protein autophosphorylation (GO:0031954)1.80774755
96neuron projection extension (GO:1990138)1.80720337
97replication fork processing (GO:0031297)1.80518792
98G-protein coupled glutamate receptor signaling pathway (GO:0007216)1.80439914
99cytoskeleton-dependent intracellular transport (GO:0030705)1.79827077
100COPII vesicle coating (GO:0048208)1.79761728

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.30555583
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.90603628
3GBX2_23144817_ChIP-Seq_PC3_Human3.15465507
4ZNF274_21170338_ChIP-Seq_K562_Hela2.78502640
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.69946544
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.55383183
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.54583991
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.47450543
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.29276455
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21177005
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.11729500
12IGF1R_20145208_ChIP-Seq_DFB_Human2.04610326
13FUS_26573619_Chip-Seq_HEK293_Human1.97232766
14POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91689230
15SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.88397965
16HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.86991963
17TAF15_26573619_Chip-Seq_HEK293_Human1.84677260
18SMAD4_21799915_ChIP-Seq_A2780_Human1.82800140
19PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79500443
20PIAS1_25552417_ChIP-Seq_VCAP_Human1.78276783
21RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78116515
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76148567
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.76122552
24SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.71225664
25EWS_26573619_Chip-Seq_HEK293_Human1.69159290
26WT1_19549856_ChIP-ChIP_CCG9911_Human1.64839674
27P300_19829295_ChIP-Seq_ESCs_Human1.64501430
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.64179473
29TOP2B_26459242_ChIP-Seq_MCF-7_Human1.63058112
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.62052701
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.60334895
32STAT3_23295773_ChIP-Seq_U87_Human1.58632849
33TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.51410819
34MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49115865
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46997160
36SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45716026
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45501351
38CBP_20019798_ChIP-Seq_JUKART_Human1.42202198
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42202198
40EP300_21415370_ChIP-Seq_HL-1_Mouse1.39022869
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.38761207
42OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38052094
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.37533797
44ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36414035
45AR_25329375_ChIP-Seq_VCAP_Human1.35281026
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.32277854
47TBX3_20139965_ChIP-Seq_MESCs_Mouse1.25312490
48TBX3_20139965_ChIP-Seq_ESCs_Mouse1.24384659
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24175652
50UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22737061
51KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.21809787
52CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21278008
53RNF2_27304074_Chip-Seq_NSC_Mouse1.20655045
54TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20149629
55TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.19584214
56TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19553936
57RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.19019295
58CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.18965240
59STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.18529591
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18518860
61* TCF4_23295773_ChIP-Seq_U87_Human1.18485162
62SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.18369966
63TP53_18474530_ChIP-ChIP_U2OS_Human1.18036445
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.17405214
65SOX9_26525672_Chip-Seq_HEART_Mouse1.14254206
66NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13661462
67KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12238514
68RUNX2_22187159_ChIP-Seq_PCA_Human1.12212098
69NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12120209
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10654634
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10654634
72PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10217652
73HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09841506
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09795739
75YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09299043
76NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09180830
77BCAT_22108803_ChIP-Seq_LS180_Human1.08776879
78TAL1_26923725_Chip-Seq_HPCs_Mouse1.07710745
79SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.07529400
80REST_21632747_ChIP-Seq_MESCs_Mouse1.07489752
81AHR_22903824_ChIP-Seq_MCF-7_Human1.06620514
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.06601246
83TCF4_18268006_ChIP-ChIP_LS174T_Human1.05342802
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.05108151
85VDR_22108803_ChIP-Seq_LS180_Human1.05096784
86CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04671603
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04333842
88LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03451962
89TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03404567
90SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02913139
91TP63_19390658_ChIP-ChIP_HaCaT_Human1.00295701
92RNF2_18974828_ChIP-Seq_MESCs_Mouse0.99073070
93EZH2_18974828_ChIP-Seq_MESCs_Mouse0.99073070
94CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.98997907
95SMAD4_21741376_ChIP-Seq_EPCs_Human0.98220494
96SMAD4_21741376_ChIP-Seq_HESCs_Human0.97380674
97SMAD3_21741376_ChIP-Seq_HESCs_Human0.97268240
98KDM2B_26808549_Chip-Seq_REH_Human0.97137392
99SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.95996700
100JUN_21703547_ChIP-Seq_K562_Human0.95961352

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation2.26934786
2MP0001529_abnormal_vocalization2.24595488
3MP0004272_abnormal_basement_membrane2.00878694
4MP0000778_abnormal_nervous_system1.91639028
5MP0003890_abnormal_embryonic-extraembry1.90672402
6MP0002909_abnormal_adrenal_gland1.90649444
7MP0003718_maternal_effect1.85438300
8MP0001299_abnormal_eye_distance/1.81954802
9MP0000566_synostosis1.81650853
10MP0006276_abnormal_autonomic_nervous1.81260956
11MP0010368_abnormal_lymphatic_system1.73528338
12MP0003122_maternal_imprinting1.69855588
13MP0003121_genomic_imprinting1.69341668
14MP0001984_abnormal_olfaction1.61727601
15MP0004270_analgesia1.59454512
16MP0008438_abnormal_cutaneous_collagen1.55264377
17MP0004859_abnormal_synaptic_plasticity1.53541094
18MP0009780_abnormal_chondrocyte_physiolo1.49341327
19MP0004885_abnormal_endolymph1.44765875
20MP0003937_abnormal_limbs/digits/tail_de1.38386464
21MP0002735_abnormal_chemical_nociception1.37401609
22MP0005499_abnormal_olfactory_system1.34965821
23MP0005394_taste/olfaction_phenotype1.34965821
24MP0009384_cardiac_valve_regurgitation1.31961571
25MP0003941_abnormal_skin_development1.31402541
26MP0000537_abnormal_urethra_morphology1.31220005
27MP0002653_abnormal_ependyma_morphology1.30866139
28MP0006054_spinal_hemorrhage1.27873093
29MP0000534_abnormal_ureter_morphology1.25887487
30MP0003755_abnormal_palate_morphology1.25589393
31MP0003136_yellow_coat_color1.25326165
32MP0002234_abnormal_pharynx_morphology1.24551772
33MP0003787_abnormal_imprinting1.21476637
34MP0008789_abnormal_olfactory_epithelium1.21426230
35MP0002837_dystrophic_cardiac_calcinosis1.17254170
36MP0006292_abnormal_olfactory_placode1.16931488
37MP0002938_white_spotting1.16560221
38MP0004134_abnormal_chest_morphology1.15200959
39MP0000428_abnormal_craniofacial_morphol1.13146549
40MP0002160_abnormal_reproductive_system1.12200672
41MP0005367_renal/urinary_system_phenotyp1.11967484
42MP0000516_abnormal_urinary_system1.11967484
43MP0003880_abnormal_central_pattern1.11711315
44MP0000013_abnormal_adipose_tissue1.10691536
45MP0003119_abnormal_digestive_system1.09818675
46MP0005275_abnormal_skin_tensile1.09311335
47MP0003942_abnormal_urinary_system1.08227601
48MP0001293_anophthalmia1.06008061
49MP0005623_abnormal_meninges_morphology1.05176379
50MP0005187_abnormal_penis_morphology1.05102988
51MP0006072_abnormal_retinal_apoptosis1.04331129
52MP0002697_abnormal_eye_size1.03722481
53MP0010352_gastrointestinal_tract_polyps1.03409653
54MP0005423_abnormal_somatic_nervous1.03171733
55MP0009250_abnormal_appendicular_skeleto1.03152953
56MP0002084_abnormal_developmental_patter1.02361007
57MP0000762_abnormal_tongue_morphology1.02047682
58MP0000579_abnormal_nail_morphology1.00947414
59MP0002233_abnormal_nose_morphology1.00726634
60MP0003861_abnormal_nervous_system1.00378056
61MP0010678_abnormal_skin_adnexa1.00317286
62MP0002822_catalepsy1.00014164
63MP0003935_abnormal_craniofacial_develop0.99275144
64MP0000631_abnormal_neuroendocrine_gland0.99017365
65MP0010234_abnormal_vibrissa_follicle0.98829072
66MP0002295_abnormal_pulmonary_circulatio0.97967153
67MP0003283_abnormal_digestive_organ0.96316950
68MP0003385_abnormal_body_wall0.94828675
69MP0003635_abnormal_synaptic_transmissio0.93946256
70MP0003123_paternal_imprinting0.93596584
71MP0002163_abnormal_gland_morphology0.93526315
72MP0000427_abnormal_hair_cycle0.93421793
73MP0010030_abnormal_orbit_morphology0.92989158
74MP0000049_abnormal_middle_ear0.92447842
75MP0001177_atelectasis0.92073722
76MP0002184_abnormal_innervation0.92046188
77MP0000383_abnormal_hair_follicle0.92013573
78MP0004145_abnormal_muscle_electrophysio0.91656759
79MP0002734_abnormal_mechanical_nocicepti0.90491565
80MP0002557_abnormal_social/conspecific_i0.90225106
81MP0001286_abnormal_eye_development0.88613547
82MP0000647_abnormal_sebaceous_gland0.87260088
83MP0008057_abnormal_DNA_replication0.86033920
84MP0002572_abnormal_emotion/affect_behav0.85849771
85MP0005503_abnormal_tendon_morphology0.82969022
86MP0002116_abnormal_craniofacial_bone0.82682995
87MP0002272_abnormal_nervous_system0.82014070
88MP0005386_behavior/neurological_phenoty0.80665783
89MP0004924_abnormal_behavior0.80665783
90MP0002085_abnormal_embryonic_tissue0.79904650
91MP0002152_abnormal_brain_morphology0.79877736
92MP0002081_perinatal_lethality0.77998002
93MP0001879_abnormal_lymphatic_vessel0.77900501
94MP0005508_abnormal_skeleton_morphology0.76454857
95MP0001486_abnormal_startle_reflex0.76002588
96MP0009046_muscle_twitch0.75665587
97MP0003567_abnormal_fetal_cardiomyocyte0.75529722
98MP0000955_abnormal_spinal_cord0.74444033
99MP0004811_abnormal_neuron_physiology0.74328225
100MP0002882_abnormal_neuron_morphology0.74270843

Predicted human phenotypes

RankGene SetZ-score
1Hepatoblastoma (HP:0002884)5.47567304
2Hypoglycemic coma (HP:0001325)4.82859613
3Hypoglycemic seizures (HP:0002173)4.24469000
4Hyperinsulinemic hypoglycemia (HP:0000825)3.97424601
5Proximal tubulopathy (HP:0000114)3.36133360
6Abnormality of dentin (HP:0010299)2.77092404
7Gout (HP:0001997)2.75777426
8Papillary thyroid carcinoma (HP:0002895)2.55213062
9Symptomatic seizures (HP:0011145)2.54265326
10Abnormality of the metopic suture (HP:0005556)2.48522194
11EEG with generalized epileptiform discharges (HP:0011198)2.33003936
12Abnormality of endocrine pancreas physiology (HP:0012093)2.31878208
13Abnormality of the pancreatic islet cells (HP:0006476)2.31878208
14Hypsarrhythmia (HP:0002521)2.30254298
15Median cleft lip (HP:0000161)2.27584456
16Gait imbalance (HP:0002141)2.24206382
17Epileptiform EEG discharges (HP:0011182)2.23086413
18Prominent metopic ridge (HP:0005487)2.22719827
19Nephronophthisis (HP:0000090)2.20818050
20Abnormality of the labia minora (HP:0012880)2.17728282
21Medial flaring of the eyebrow (HP:0010747)2.16908574
22Congenital primary aphakia (HP:0007707)2.08949050
23Pancreatic cysts (HP:0001737)2.07530019
24Coronal craniosynostosis (HP:0004440)2.07491511
25Follicular hyperkeratosis (HP:0007502)2.05782145
26Thyroid carcinoma (HP:0002890)2.05417044
27Genital tract atresia (HP:0001827)2.01867057
28Chronic hepatic failure (HP:0100626)1.99568192
29Neoplasm of the oral cavity (HP:0100649)1.97977765
30Hydroureter (HP:0000072)1.97939378
31Abnormality of the astrocytes (HP:0100707)1.97764526
32Astrocytoma (HP:0009592)1.97764526
33Postaxial hand polydactyly (HP:0001162)1.97092019
34Ketosis (HP:0001946)1.95523586
35Intestinal atresia (HP:0011100)1.94956211
36Vaginal atresia (HP:0000148)1.94573038
37Late onset (HP:0003584)1.93239822
38Abnormality of the renal cortex (HP:0011035)1.90242863
39Ketoacidosis (HP:0001993)1.88250641
40Hyperglycemia (HP:0003074)1.86481985
41Bifid tongue (HP:0010297)1.84225547
42Gonadotropin excess (HP:0000837)1.80355907
43Tubular atrophy (HP:0000092)1.80272485
44Nephrogenic diabetes insipidus (HP:0009806)1.80206813
45Pancreatic fibrosis (HP:0100732)1.79816827
46Abnormality of the renal medulla (HP:0100957)1.78691782
47Molar tooth sign on MRI (HP:0002419)1.78013596
48Abnormality of midbrain morphology (HP:0002418)1.78013596
49Facial hemangioma (HP:0000329)1.77885313
50Supernumerary spleens (HP:0009799)1.76177758
51Drooling (HP:0002307)1.71494985
52Atonic seizures (HP:0010819)1.70851175
53Glioma (HP:0009733)1.70162981
54Intellectual disability, moderate (HP:0002342)1.68198422
55Ependymoma (HP:0002888)1.64696549
56Poor coordination (HP:0002370)1.63972639
57Cutaneous finger syndactyly (HP:0010554)1.63959104
58Wide anterior fontanel (HP:0000260)1.63242085
59Anterior segment dysgenesis (HP:0007700)1.62301030
60Aplasia/Hypoplasia of the tibia (HP:0005772)1.61112412
61Enlarged kidneys (HP:0000105)1.59403651
62Abnormality of the phalanges of the hallux (HP:0010057)1.58787395
63Heterotopia (HP:0002282)1.58440263
64Premature rupture of membranes (HP:0001788)1.58023455
65Shawl scrotum (HP:0000049)1.56393598
66Hypoplastic scapulae (HP:0000882)1.56014663
67Aplasia/Hypoplasia of the scapulae (HP:0006713)1.56014663
68Decreased testicular size (HP:0008734)1.55578534
69Hemiparesis (HP:0001269)1.53562162
70Renal hypoplasia (HP:0000089)1.53549591
71Short tibia (HP:0005736)1.52507583
72Pachygyria (HP:0001302)1.50670140
73Abnormality of the aortic arch (HP:0012303)1.49173831
74Facial cleft (HP:0002006)1.48994628
75Short foot (HP:0001773)1.48350337
76Atrophic scars (HP:0001075)1.48162780
77Omphalocele (HP:0001539)1.47917839
78Hypoplastic labia majora (HP:0000059)1.46288982
79Unilateral renal agenesis (HP:0000122)1.45913612
80Atrioventricular canal defect (HP:0006695)1.45861218
81Muscular hypotonia of the trunk (HP:0008936)1.44600500
82Bicornuate uterus (HP:0000813)1.44161596
83Action tremor (HP:0002345)1.43453827
84Oligodactyly (hands) (HP:0001180)1.43373215
85Complete atrioventricular canal defect (HP:0001674)1.43099963
86Septo-optic dysplasia (HP:0100842)1.42777511
87Cortical dysplasia (HP:0002539)1.41521536
88Micropenis (HP:0000054)1.41384092
89Aplasia/Hypoplasia of the tongue (HP:0010295)1.40389173
90Stage 5 chronic kidney disease (HP:0003774)1.40091774
91Shallow orbits (HP:0000586)1.39334084
92Hypomagnesemia (HP:0002917)1.38539787
93True hermaphroditism (HP:0010459)1.38361279
94Neonatal short-limb short stature (HP:0008921)1.38031638
95Excessive salivation (HP:0003781)1.37965616
96Bowel diverticulosis (HP:0005222)1.37748698
97Focal segmental glomerulosclerosis (HP:0000097)1.37551068
98Medulloblastoma (HP:0002885)1.37378152
99Dental crowding (HP:0000678)1.37257754
100Cutaneous syndactyly (HP:0012725)1.36389310

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.92201890
2FRK3.89509217
3PNCK3.36013152
4PDK22.74225780
5MARK12.69890953
6MAP3K42.05105096
7TRIM282.04996892
8EPHB21.94787922
9MAP3K91.83815972
10BCR1.81954906
11NTRK21.76290529
12CSNK1G11.71475568
13MAP2K71.68576436
14FGFR21.64759646
15PINK11.60908067
16WNK31.58749739
17STK31.55358240
18ARAF1.54336353
19EIF2AK31.48034497
20TNIK1.41062221
21MAPK131.39797813
22CAMK1G1.38426944
23NTRK11.34470902
24NTRK31.24074417
25CSNK1G21.24044064
26PLK21.21109771
27DDR21.21070842
28CDC71.20520133
29CSNK1G31.18864155
30EPHA31.17180288
31NEK61.13539918
32MET1.13156559
33CSNK1A1L1.06767783
34STK381.05190512
35PTK21.03604854
36SRPK11.00990017
37ERBB40.99847376
38DYRK20.98832296
39KSR10.98653895
40BRD40.97303391
41MAPK70.97225094
42NEK90.94790833
43BMPR1B0.94530164
44PAK20.91370114
45PLK30.87990969
46TIE10.86027000
47PRKCE0.85788932
48PDGFRA0.84672476
49ERBB30.82766262
50CAMK2D0.79611975
51PRKD30.78078972
52TTK0.77093373
53AKT30.74891090
54MAPK150.74395856
55PAK60.74276440
56TSSK60.73115707
57DYRK1A0.71244050
58SGK20.71164407
59PRKD20.69400550
60PHKG10.68223929
61PHKG20.68223929
62PLK40.66252343
63MAP4K20.65360229
64NLK0.64657353
65PAK30.64132067
66ROCK10.63235886
67MOS0.62685987
68SCYL20.62538969
69TGFBR10.61007255
70CDK90.60718625
71ATM0.60513129
72FER0.59433069
73SGK4940.59078700
74SGK2230.59078700
75RAF10.58793998
76PRKCG0.57203629
77CSNK1A10.57144178
78GRK10.56835233
79CAMK2B0.56405405
80AURKA0.55700394
81LATS10.53779114
82YES10.51959719
83CAMK2G0.51393366
84CDK30.51245338
85PRKCZ0.50458083
86MTOR0.50382262
87LATS20.50176599
88BCKDK0.49818109
89CAMK2A0.49249993
90GSK3A0.48359391
91ROCK20.48254141
92PRKACB0.48204232
93PRKCI0.47417638
94PLK10.47293127
95CDK80.47068636
96DYRK30.46553553
97MKNK20.45978562
98CSNK1E0.45824561
99CDK50.45626931
100SGK30.44442934

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.59423652
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.42750255
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.28336316
4Butanoate metabolism_Homo sapiens_hsa006502.22790754
5Steroid biosynthesis_Homo sapiens_hsa001002.12513292
6Insulin secretion_Homo sapiens_hsa049111.93522339
7Fatty acid elongation_Homo sapiens_hsa000621.90786186
8Propanoate metabolism_Homo sapiens_hsa006401.73086465
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.68812113
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.60464433
11Basal transcription factors_Homo sapiens_hsa030221.50833481
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42274663
13Hippo signaling pathway_Homo sapiens_hsa043901.40508247
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38170980
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34257310
16Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.33126770
17ECM-receptor interaction_Homo sapiens_hsa045121.30311810
18Fatty acid metabolism_Homo sapiens_hsa012121.20205992
19Regulation of autophagy_Homo sapiens_hsa041401.19723945
20Hedgehog signaling pathway_Homo sapiens_hsa043401.17849221
21Nicotine addiction_Homo sapiens_hsa050331.17350708
22Selenocompound metabolism_Homo sapiens_hsa004501.16923337
23Axon guidance_Homo sapiens_hsa043601.16797761
24Protein export_Homo sapiens_hsa030601.13221825
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.11006825
26GABAergic synapse_Homo sapiens_hsa047271.10663757
27Ovarian steroidogenesis_Homo sapiens_hsa049131.07205421
28Lysine degradation_Homo sapiens_hsa003101.06961179
29Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.05727830
30Gap junction_Homo sapiens_hsa045401.05487489
31Fanconi anemia pathway_Homo sapiens_hsa034601.00428398
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98448876
33Glutamatergic synapse_Homo sapiens_hsa047240.95748036
34Basal cell carcinoma_Homo sapiens_hsa052170.94590396
35Oocyte meiosis_Homo sapiens_hsa041140.93490316
36Cocaine addiction_Homo sapiens_hsa050300.90954084
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89466137
38Adherens junction_Homo sapiens_hsa045200.86481432
39Tight junction_Homo sapiens_hsa045300.85363905
40Pyruvate metabolism_Homo sapiens_hsa006200.85352300
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85037164
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84830305
43Dilated cardiomyopathy_Homo sapiens_hsa054140.83024926
44Thyroid hormone synthesis_Homo sapiens_hsa049180.82908733
45Long-term depression_Homo sapiens_hsa047300.82590478
46Taste transduction_Homo sapiens_hsa047420.82052700
47Non-homologous end-joining_Homo sapiens_hsa034500.81931189
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.81599354
49Protein digestion and absorption_Homo sapiens_hsa049740.79643228
50RNA transport_Homo sapiens_hsa030130.79482734
51Circadian entrainment_Homo sapiens_hsa047130.77479968
52beta-Alanine metabolism_Homo sapiens_hsa004100.77329850
53Melanogenesis_Homo sapiens_hsa049160.77058275
54TGF-beta signaling pathway_Homo sapiens_hsa043500.76848501
55Type II diabetes mellitus_Homo sapiens_hsa049300.76591954
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75459246
57Melanoma_Homo sapiens_hsa052180.75025120
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74767929
59Wnt signaling pathway_Homo sapiens_hsa043100.73921012
60Phototransduction_Homo sapiens_hsa047440.73890801
61ABC transporters_Homo sapiens_hsa020100.73677050
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.72907937
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70454982
64Focal adhesion_Homo sapiens_hsa045100.70335559
65Dopaminergic synapse_Homo sapiens_hsa047280.69290476
66Cell cycle_Homo sapiens_hsa041100.67122849
67Synaptic vesicle cycle_Homo sapiens_hsa047210.67045609
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67029343
69Nucleotide excision repair_Homo sapiens_hsa034200.66935079
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66692460
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66602118
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66024633
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65526707
74Circadian rhythm_Homo sapiens_hsa047100.65163236
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62965740
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61354379
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61201169
78Glucagon signaling pathway_Homo sapiens_hsa049220.60087742
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59315363
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59092314
81Vibrio cholerae infection_Homo sapiens_hsa051100.58238195
82MicroRNAs in cancer_Homo sapiens_hsa052060.57356729
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56497172
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55172684
85cAMP signaling pathway_Homo sapiens_hsa040240.54820655
86Amphetamine addiction_Homo sapiens_hsa050310.53587839
87Cholinergic synapse_Homo sapiens_hsa047250.52357175
88Tryptophan metabolism_Homo sapiens_hsa003800.51537178
89Homologous recombination_Homo sapiens_hsa034400.50956112
90RNA degradation_Homo sapiens_hsa030180.50338573
91Morphine addiction_Homo sapiens_hsa050320.49278312
92Rap1 signaling pathway_Homo sapiens_hsa040150.48809092
93Serotonergic synapse_Homo sapiens_hsa047260.47837870
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47492051
95AMPK signaling pathway_Homo sapiens_hsa041520.47265448
96Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47136572
97PI3K-Akt signaling pathway_Homo sapiens_hsa041510.46460588
98mRNA surveillance pathway_Homo sapiens_hsa030150.45336506
99Fatty acid degradation_Homo sapiens_hsa000710.45265664
100Mismatch repair_Homo sapiens_hsa034300.44961645

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