ZNF224

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein represses transcription of the aldolase A gene, which encodes a key enzyme in glycolysis. The encoded zinc-finger protein may also function as a transcriptional co-activator with Wilms' tumor protein 1 to regulate apoptotic genes in leukemia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neural tube formation (GO:0001841)5.51846985
2protein K11-linked deubiquitination (GO:0035871)5.18124580
3activated T cell proliferation (GO:0050798)4.07106656
4monoubiquitinated protein deubiquitination (GO:0035520)3.93635086
5cilium or flagellum-dependent cell motility (GO:0001539)3.88346521
6positive regulation of developmental pigmentation (GO:0048087)3.85767509
7indolalkylamine metabolic process (GO:0006586)3.73691399
8detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.57664292
9tryptophan catabolic process (GO:0006569)3.45991337
10indole-containing compound catabolic process (GO:0042436)3.45991337
11indolalkylamine catabolic process (GO:0046218)3.45991337
12reflex (GO:0060004)3.43692937
13negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.31472684
14negative regulation of translation, ncRNA-mediated (GO:0040033)3.31472684
15regulation of translation, ncRNA-mediated (GO:0045974)3.31472684
16regulation of B cell receptor signaling pathway (GO:0050855)3.23783450
17regulation of memory T cell differentiation (GO:0043380)3.22274721
18establishment of protein localization to Golgi (GO:0072600)3.21192808
19detection of light stimulus involved in sensory perception (GO:0050962)3.20897243
20detection of light stimulus involved in visual perception (GO:0050908)3.20897243
21regulation of collateral sprouting (GO:0048670)3.17905125
22regulation of pigment cell differentiation (GO:0050932)3.15145441
23histone H3-K4 trimethylation (GO:0080182)3.12652347
24pyrimidine nucleobase catabolic process (GO:0006208)3.12301786
25fucose catabolic process (GO:0019317)3.11711482
26L-fucose metabolic process (GO:0042354)3.11711482
27L-fucose catabolic process (GO:0042355)3.11711482
28epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.09043859
29photoreceptor cell maintenance (GO:0045494)3.07935918
30cornea development in camera-type eye (GO:0061303)3.05306675
31central nervous system neuron axonogenesis (GO:0021955)3.03720980
32rRNA catabolic process (GO:0016075)3.03482064
33cell wall macromolecule catabolic process (GO:0016998)3.02425261
34regulation of sarcomere organization (GO:0060297)3.01856194
35histone H3-K9 methylation (GO:0051567)2.98385910
36kynurenine metabolic process (GO:0070189)2.95903949
37signal peptide processing (GO:0006465)2.94442810
38protein K48-linked deubiquitination (GO:0071108)2.93696745
39central nervous system projection neuron axonogenesis (GO:0021952)2.92103634
40tryptophan metabolic process (GO:0006568)2.91983341
41mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.91677621
42positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.91677621
43limb bud formation (GO:0060174)2.91270104
44gamma-aminobutyric acid transport (GO:0015812)2.84763484
45positive regulation of oligodendrocyte differentiation (GO:0048714)2.81186521
46startle response (GO:0001964)2.77990187
47protein prenylation (GO:0018342)2.77519062
48prenylation (GO:0097354)2.77519062
49negative regulation of mast cell activation (GO:0033004)2.76881592
50cellular response to ethanol (GO:0071361)2.72593223
51embryonic epithelial tube formation (GO:0001838)2.71869347
52centriole replication (GO:0007099)2.71524435
53cell wall macromolecule metabolic process (GO:0044036)2.71252084
54cilium morphogenesis (GO:0060271)2.70997887
55protein K63-linked deubiquitination (GO:0070536)2.70900800
56histone H3-K9 modification (GO:0061647)2.70290072
57peptidyl-lysine trimethylation (GO:0018023)2.69351430
58tachykinin receptor signaling pathway (GO:0007217)2.68910165
59histone mRNA catabolic process (GO:0071044)2.68378516
60axoneme assembly (GO:0035082)2.66510189
61regulation of hippo signaling (GO:0035330)2.66254371
62indole-containing compound metabolic process (GO:0042430)2.66025096
63lipid translocation (GO:0034204)2.65918812
64phospholipid translocation (GO:0045332)2.65918812
65positive regulation of granulocyte differentiation (GO:0030854)2.65728150
66response to pheromone (GO:0019236)2.62825402
67positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.62242379
68DNA double-strand break processing (GO:0000729)2.61280320
69cellular response to sterol (GO:0036315)2.61200480
70interferon-gamma production (GO:0032609)2.60704986
71nucleobase catabolic process (GO:0046113)2.60043787
72presynaptic membrane assembly (GO:0097105)2.58878163
73glycosphingolipid biosynthetic process (GO:0006688)2.56805427
74inner ear receptor stereocilium organization (GO:0060122)2.56455437
75sulfation (GO:0051923)2.52428322
76cAMP catabolic process (GO:0006198)2.51650467
77head development (GO:0060322)2.50970075
78negative regulation of calcium ion transport into cytosol (GO:0010523)2.50829408
79auditory receptor cell stereocilium organization (GO:0060088)2.50400876
80phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.49893644
81regulation of MHC class I biosynthetic process (GO:0045343)2.49027262
82neuronal action potential propagation (GO:0019227)2.46537595
83negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.46367876
84behavioral response to nicotine (GO:0035095)2.45735019
85protein targeting to Golgi (GO:0000042)2.45720475
86proline transport (GO:0015824)2.44556537
87neuronal action potential (GO:0019228)2.44456141
88epithelial tube formation (GO:0072175)2.43170403
89G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.43088225
90retinal cone cell development (GO:0046549)2.42822786
91behavioral response to ethanol (GO:0048149)2.42772245
92cyclic nucleotide catabolic process (GO:0009214)2.42663773
93adaptation of signaling pathway (GO:0023058)2.40707791
94cellular biogenic amine catabolic process (GO:0042402)2.39968304
95amine catabolic process (GO:0009310)2.39968304
96cytoplasmic mRNA processing body assembly (GO:0033962)2.38468840
97epithelial cilium movement (GO:0003351)2.37687389
98serotonin metabolic process (GO:0042428)2.37058558
99cilium organization (GO:0044782)2.37053825
100cilium assembly (GO:0042384)2.35547355

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.51825293
2ZNF274_21170338_ChIP-Seq_K562_Hela3.07998891
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.96275670
4POU3F2_20337985_ChIP-ChIP_501MEL_Human2.88497476
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.82461595
6IGF1R_20145208_ChIP-Seq_DFB_Human2.81940553
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.65725370
8TAF15_26573619_Chip-Seq_HEK293_Human2.58820988
9EZH2_22144423_ChIP-Seq_EOC_Human2.58574796
10VDR_22108803_ChIP-Seq_LS180_Human2.52403405
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.42884382
12* FUS_26573619_Chip-Seq_HEK293_Human2.33031513
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.31208954
14EWS_26573619_Chip-Seq_HEK293_Human2.12341544
15P300_19829295_ChIP-Seq_ESCs_Human2.11758340
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07789469
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.06449490
18SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.05601496
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02830251
20AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.99932801
21SMAD_19615063_ChIP-ChIP_OVARY_Human1.96144929
22ER_23166858_ChIP-Seq_MCF-7_Human1.93856606
23PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.89029132
24BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.88955377
25STAT3_23295773_ChIP-Seq_U87_Human1.80673313
26SMAD4_21799915_ChIP-Seq_A2780_Human1.80475798
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.80467498
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67405925
29UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.66807128
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.64458904
31TCF4_23295773_ChIP-Seq_U87_Human1.58407725
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.57689521
33CBP_20019798_ChIP-Seq_JUKART_Human1.57689521
34BCAT_22108803_ChIP-Seq_LS180_Human1.57542863
35AR_21572438_ChIP-Seq_LNCaP_Human1.56640311
36NR3C1_21868756_ChIP-Seq_MCF10A_Human1.53295927
37AR_25329375_ChIP-Seq_VCAP_Human1.51494581
38SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49806000
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49446276
40SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48691392
41OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48545079
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.48100280
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47267949
44EZH2_27294783_Chip-Seq_NPCs_Mouse1.46367890
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.45661361
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42406643
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42406643
48FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.38549595
49CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.35937353
50FLI1_21867929_ChIP-Seq_TH2_Mouse1.35276369
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34624608
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.34459407
53RUNX2_22187159_ChIP-Seq_PCA_Human1.34325472
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.34054098
55STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.32231108
56TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31833331
57NANOG_18555785_Chip-Seq_ESCs_Mouse1.31581334
58PRDM14_20953172_ChIP-Seq_ESCs_Human1.30390803
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29068017
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28408288
61TP53_16413492_ChIP-PET_HCT116_Human1.23732462
62CRX_20693478_ChIP-Seq_RETINA_Mouse1.22548387
63TCF4_22108803_ChIP-Seq_LS180_Human1.22117737
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.22075493
65EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21861168
66KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21017169
67OCT4_21477851_ChIP-Seq_ESCs_Mouse1.19957767
68* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18290930
69IRF8_22096565_ChIP-ChIP_GC-B_Human1.18083070
70PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17002189
71P53_22387025_ChIP-Seq_ESCs_Mouse1.14775486
72E2F1_18555785_Chip-Seq_ESCs_Mouse1.12142154
73MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11946508
74TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11891452
75SMAD4_21741376_ChIP-Seq_EPCs_Human1.11248429
76TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10751058
77TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10278991
78TP53_22573176_ChIP-Seq_HFKS_Human1.09966383
79EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09944710
80ARNT_22903824_ChIP-Seq_MCF-7_Human1.08830561
81FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08817785
82SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.08283632
83KDM2B_26808549_Chip-Seq_REH_Human1.06464465
84SOX2_21211035_ChIP-Seq_LN229_Gbm1.06415266
85CDX2_22108803_ChIP-Seq_LS180_Human1.06112634
86CMYC_18555785_Chip-Seq_ESCs_Mouse1.06011156
87NANOG_19829295_ChIP-Seq_ESCs_Human1.04622157
88SOX2_19829295_ChIP-Seq_ESCs_Human1.04622157
89EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04320134
90SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03295330
91IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01760869
92P300_18555785_Chip-Seq_ESCs_Mouse1.01588179
93REST_21632747_ChIP-Seq_MESCs_Mouse1.01355532
94RNF2_27304074_Chip-Seq_NSC_Mouse1.00207075
95IRF1_19129219_ChIP-ChIP_H3396_Human1.00060931
96DROSHA_22980978_ChIP-Seq_HELA_Human0.98643557
97CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97983058
98STAT3_18555785_Chip-Seq_ESCs_Mouse0.97377681
99TAL1_26923725_Chip-Seq_HPCs_Mouse0.97264645
100AHR_22903824_ChIP-Seq_MCF-7_Human0.97153016

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.97450558
2MP0008057_abnormal_DNA_replication3.01803762
3MP0008877_abnormal_DNA_methylation2.80653681
4MP0001986_abnormal_taste_sensitivity2.80270176
5MP0003787_abnormal_imprinting2.77613984
6MP0003195_calcinosis2.40062991
7MP0003880_abnormal_central_pattern2.33262089
8MP0001501_abnormal_sleep_pattern2.22682801
9MP0005551_abnormal_eye_electrophysiolog2.16799439
10MP0001968_abnormal_touch/_nociception2.11791858
11MP0005645_abnormal_hypothalamus_physiol2.09216410
12MP0001486_abnormal_startle_reflex2.04064929
13MP0005367_renal/urinary_system_phenotyp1.99524230
14MP0000516_abnormal_urinary_system1.99524230
15MP0001984_abnormal_olfaction1.87303540
16MP0009046_muscle_twitch1.84136435
17MP0003724_increased_susceptibility_to1.82845346
18MP0002102_abnormal_ear_morphology1.70730575
19MP0004043_abnormal_pH_regulation1.69645665
20MP0002736_abnormal_nociception_after1.66892362
21MP0009745_abnormal_behavioral_response1.63324557
22MP0005310_abnormal_salivary_gland1.58077931
23MP0006276_abnormal_autonomic_nervous1.58061396
24MP0005174_abnormal_tail_pigmentation1.52326556
25MP0003136_yellow_coat_color1.52306050
26MP0005075_abnormal_melanosome_morpholog1.50443187
27MP0000427_abnormal_hair_cycle1.46557352
28MP0002928_abnormal_bile_duct1.46259691
29MP0005187_abnormal_penis_morphology1.44944727
30MP0005253_abnormal_eye_physiology1.41145547
31MP0002735_abnormal_chemical_nociception1.40561927
32MP0005386_behavior/neurological_phenoty1.37599294
33MP0004924_abnormal_behavior1.37599294
34MP0002095_abnormal_skin_pigmentation1.36734131
35MP0002064_seizures1.36018001
36MP0005423_abnormal_somatic_nervous1.31287869
37MP0004742_abnormal_vestibular_system1.30505345
38MP0000015_abnormal_ear_pigmentation1.29220562
39MP0008995_early_reproductive_senescence1.28143792
40MP0003252_abnormal_bile_duct1.26017379
41MP0002067_abnormal_sensory_capabilities1.25295782
42MP0003635_abnormal_synaptic_transmissio1.22866014
43MP0000778_abnormal_nervous_system1.21820326
44MP0002572_abnormal_emotion/affect_behav1.20291319
45MP0003183_abnormal_peptide_metabolism1.19264001
46MP0004142_abnormal_muscle_tone1.18154906
47MP0002272_abnormal_nervous_system1.16292343
48MP0002638_abnormal_pupillary_reflex1.15886377
49MP0005671_abnormal_response_to1.10718147
50MP0000631_abnormal_neuroendocrine_gland1.09384311
51MP0003763_abnormal_thymus_physiology1.08718182
52MP0002557_abnormal_social/conspecific_i1.08550702
53MP0003045_fibrosis1.08074948
54MP0002063_abnormal_learning/memory/cond1.07027138
55MP0004381_abnormal_hair_follicle1.06234075
56MP0005646_abnormal_pituitary_gland1.03454972
57MP0002876_abnormal_thyroid_physiology1.02891449
58MP0002138_abnormal_hepatobiliary_system1.02544275
59MP0001764_abnormal_homeostasis1.01522637
60MP0006072_abnormal_retinal_apoptosis1.00263184
61MP0004147_increased_porphyrin_level0.95334351
62MP0001970_abnormal_pain_threshold0.94966496
63MP0003121_genomic_imprinting0.94901345
64MP0001800_abnormal_humoral_immune0.94336416
65MP0000538_abnormal_urinary_bladder0.92429274
66MP0000372_irregular_coat_pigmentation0.92157220
67MP0000383_abnormal_hair_follicle0.90526295
68MP0002009_preneoplasia0.90435484
69MP0003633_abnormal_nervous_system0.90285667
70MP0003646_muscle_fatigue0.89371206
71MP0004484_altered_response_of0.89154310
72MP0002751_abnormal_autonomic_nervous0.87316681
73MP0003698_abnormal_male_reproductive0.85890504
74MP0001835_abnormal_antigen_presentation0.85469455
75MP0002938_white_spotting0.85111372
76MP0008872_abnormal_physiological_respon0.84706515
77MP0000371_diluted_coat_color0.84282002
78MP0001485_abnormal_pinna_reflex0.80681570
79MP0009764_decreased_sensitivity_to0.79930266
80MP0008875_abnormal_xenobiotic_pharmacok0.79215720
81MP0003943_abnormal_hepatobiliary_system0.78122585
82MP0002733_abnormal_thermal_nociception0.76226535
83MP0002168_other_aberrant_phenotype0.75999169
84MP0005389_reproductive_system_phenotype0.75164112
85MP0004215_abnormal_myocardial_fiber0.74896601
86MP0001502_abnormal_circadian_rhythm0.73412603
87MP0002229_neurodegeneration0.73298642
88MP0003631_nervous_system_phenotype0.72378480
89MP0002837_dystrophic_cardiac_calcinosis0.71509909
90MP0002882_abnormal_neuron_morphology0.70985392
91MP0006082_CNS_inflammation0.70090857
92MP0005647_abnormal_sex_gland0.67700475
93MP0001529_abnormal_vocalization0.67574798
94MP0005195_abnormal_posterior_eye0.66728724
95MP0001790_abnormal_immune_system0.66440373
96MP0005387_immune_system_phenotype0.66440373
97MP0002734_abnormal_mechanical_nocicepti0.66363772
98MP0001919_abnormal_reproductive_system0.65791019
99MP0003656_abnormal_erythrocyte_physiolo0.64088548
100MP0002723_abnormal_immune_serum0.63569013

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)4.49739245
2Pancreatic cysts (HP:0001737)4.33183922
3Chronic hepatic failure (HP:0100626)3.93993041
4Pancreatic fibrosis (HP:0100732)3.81770501
5True hermaphroditism (HP:0010459)3.73912217
6Gaze-evoked nystagmus (HP:0000640)3.45802564
7Molar tooth sign on MRI (HP:0002419)3.38378479
8Abnormality of midbrain morphology (HP:0002418)3.38378479
9Febrile seizures (HP:0002373)3.29181768
10Genetic anticipation (HP:0003743)3.27961338
11Absent speech (HP:0001344)3.19299845
12Stomach cancer (HP:0012126)3.07975510
13Progressive cerebellar ataxia (HP:0002073)2.96610789
14Nephronophthisis (HP:0000090)2.86031949
15Protruding tongue (HP:0010808)2.83126190
16Congenital stationary night blindness (HP:0007642)2.81096411
17Abnormality of the renal cortex (HP:0011035)2.79566972
18Attenuation of retinal blood vessels (HP:0007843)2.76910210
19Fair hair (HP:0002286)2.74593813
20Cystic liver disease (HP:0006706)2.72262390
21Abnormality of the renal medulla (HP:0100957)2.71398279
22Broad-based gait (HP:0002136)2.63195130
23Congenital sensorineural hearing impairment (HP:0008527)2.62097315
24Medial flaring of the eyebrow (HP:0010747)2.56417383
25Atonic seizures (HP:0010819)2.48412540
26Bile duct proliferation (HP:0001408)2.45203702
27Abnormal biliary tract physiology (HP:0012439)2.45203702
28Abolished electroretinogram (ERG) (HP:0000550)2.44550725
29Thyroiditis (HP:0100646)2.38786788
30Focal motor seizures (HP:0011153)2.37216951
31Focal seizures (HP:0007359)2.35089787
32Widely spaced teeth (HP:0000687)2.34566977
33Drooling (HP:0002307)2.31206597
34Hypothermia (HP:0002045)2.24766467
35Excessive salivation (HP:0003781)2.24707855
36Type II lissencephaly (HP:0007260)2.24360352
37Dialeptic seizures (HP:0011146)2.23986462
38Inability to walk (HP:0002540)2.23213167
39Generalized hypopigmentation of hair (HP:0011358)2.21606356
40Gait imbalance (HP:0002141)2.20195021
41Genital tract atresia (HP:0001827)2.19546725
42Renal cortical cysts (HP:0000803)2.17452635
43Progressive inability to walk (HP:0002505)2.13924410
44Congenital primary aphakia (HP:0007707)2.12881006
45Volvulus (HP:0002580)2.07355934
46Vaginal atresia (HP:0000148)2.05334863
47Aplasia/Hypoplasia of the tibia (HP:0005772)2.02807291
48Aplasia/Hypoplasia of the tongue (HP:0010295)2.01718401
49Intestinal atresia (HP:0011100)2.00823235
50Clumsiness (HP:0002312)1.99968214
51Absence seizures (HP:0002121)1.99476436
52Decreased central vision (HP:0007663)1.98044405
53Pendular nystagmus (HP:0012043)1.96386130
54Congenital hepatic fibrosis (HP:0002612)1.95496910
55Nephrogenic diabetes insipidus (HP:0009806)1.94006606
56Tented upper lip vermilion (HP:0010804)1.93190274
57Furrowed tongue (HP:0000221)1.90837882
58Large for gestational age (HP:0001520)1.90090854
59Abnormality of macular pigmentation (HP:0008002)1.89696148
60Abnormality of B cell number (HP:0010975)1.89192426
61Abnormal drinking behavior (HP:0030082)1.88279732
62Polydipsia (HP:0001959)1.88279732
63Lissencephaly (HP:0001339)1.87478014
64Bony spicule pigmentary retinopathy (HP:0007737)1.86335805
65Abnormality of T cell number (HP:0011839)1.86142567
66Abnormal rod and cone electroretinograms (HP:0008323)1.84965327
67Optic nerve hypoplasia (HP:0000609)1.83752389
68Male pseudohermaphroditism (HP:0000037)1.83168518
69Stomatitis (HP:0010280)1.82141441
70Cerebellar dysplasia (HP:0007033)1.79246469
71Keratoconus (HP:0000563)1.78970963
72Increased corneal curvature (HP:0100692)1.78970963
73Albinism (HP:0001022)1.78757197
74Amyotrophic lateral sclerosis (HP:0007354)1.77286223
75Acute lymphatic leukemia (HP:0006721)1.77219120
76Hypochromic microcytic anemia (HP:0004840)1.75136160
77Abnormal delayed hypersensitivity skin test (HP:0002963)1.74625395
78Dynein arm defect of respiratory motile cilia (HP:0012255)1.74172277
79Absent/shortened dynein arms (HP:0200106)1.74172277
80Anencephaly (HP:0002323)1.74071706
81Narrow forehead (HP:0000341)1.73447875
82Postaxial foot polydactyly (HP:0001830)1.72616948
83Severe combined immunodeficiency (HP:0004430)1.71784738
84Exotropia (HP:0000577)1.71577512
85Constricted visual fields (HP:0001133)1.70903438
86Tubular atrophy (HP:0000092)1.68718033
87Poor coordination (HP:0002370)1.68684935
88Highly arched eyebrow (HP:0002553)1.68654863
89Occipital encephalocele (HP:0002085)1.68538191
90Oculomotor apraxia (HP:0000657)1.68282975
91Absent rod-and cone-mediated responses on ERG (HP:0007688)1.67970122
92Abnormality of chromosome stability (HP:0003220)1.66396410
93Decreased circulating renin level (HP:0003351)1.65446431
94Chronic mucocutaneous candidiasis (HP:0002728)1.64948984
95Recurrent cutaneous fungal infections (HP:0011370)1.64948984
96Tubulointerstitial nephritis (HP:0001970)1.64868430
97Retinal dysplasia (HP:0007973)1.64107640
98Cupped ear (HP:0000378)1.63110503
99Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.62212288
100Hemiparesis (HP:0001269)1.61954600

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.16554021
2WNK32.72852031
3CASK2.51802855
4MAPK132.51256824
5TAOK32.45977170
6ACVR1B2.37570508
7MAP4K22.29127514
8MAP3K42.22556768
9TXK2.19798543
10PINK12.17192211
11ADRBK21.88153641
12MARK11.83648972
13TNIK1.78609075
14NUAK11.68945422
15BMPR1B1.51621362
16MKNK21.41537701
17BCR1.38010894
18NLK1.29220258
19GRK11.26893085
20EPHA41.26288615
21TRIM281.26094087
22OXSR11.24390096
23ERBB31.22353547
24PAK31.20457541
25CAMKK21.15940124
26SIK21.11558954
27TNK21.10531857
28INSRR1.10510410
29STK38L1.03560979
30MAP2K71.01690943
31MAP2K41.01389704
32BLK1.00125185
33FGFR20.97413593
34TEC0.96258980
35NTRK30.95456948
36SGK20.94971922
37BRD40.91162501
38MAP4K10.86872797
39MARK30.83922212
40PIK3CG0.83875736
41YES10.82244507
42KIT0.81559005
43AKT30.81369908
44PRKCE0.77648090
45ADRBK10.77264951
46IKBKE0.76640957
47MKNK10.75932595
48IRAK10.75727804
49DAPK20.74704842
50ZAK0.73494808
51PTK2B0.71910531
52GRK70.70145212
53DYRK1A0.69633671
54NTRK20.69409446
55FES0.67638464
56STK390.67350784
57CSNK1G10.66985960
58MAP3K70.66647582
59SYK0.66421247
60SIK30.66007748
61JAK10.65143257
62PNCK0.64345194
63EPHA30.63853269
64BRSK20.62717204
65MAP3K50.61774998
66EIF2AK30.61653660
67CSNK1A1L0.61515766
68CAMK1G0.60934364
69MAP3K60.60814978
70IKBKB0.60378406
71STK110.57851833
72DYRK30.57533575
73PLK20.56983879
74MAPK70.54781047
75CSNK1G20.53512831
76PKN10.52921208
77PLK40.52714791
78LYN0.52258213
79TYK20.51409015
80ITK0.49588020
81PIK3CA0.49557091
82LATS10.49157948
83CAMK40.48792892
84PRKCQ0.48204667
85TGFBR10.48003759
86CDK30.47844929
87DYRK20.47255251
88PRKCG0.47138284
89PRKCZ0.46907014
90BMPR20.46816743
91FER0.46703491
92PRKAA20.45771446
93CSNK1G30.43566441
94GRK60.40490845
95SGK2230.40443359
96SGK4940.40443359
97LCK0.38842147
98FGFR30.36302843
99CAMK1D0.36028092
100CAMK2A0.36006500

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.72331191
2Phototransduction_Homo sapiens_hsa047442.36756912
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.34490483
4Taste transduction_Homo sapiens_hsa047422.26934295
5Butanoate metabolism_Homo sapiens_hsa006502.20856977
6Linoleic acid metabolism_Homo sapiens_hsa005912.09136734
7Ether lipid metabolism_Homo sapiens_hsa005651.99034155
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.98543113
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.97001406
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.93719588
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.90945189
12ABC transporters_Homo sapiens_hsa020101.87699546
13Morphine addiction_Homo sapiens_hsa050321.72254713
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.67444225
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.56661726
16Primary immunodeficiency_Homo sapiens_hsa053401.56015347
17Nitrogen metabolism_Homo sapiens_hsa009101.54215795
18Dorso-ventral axis formation_Homo sapiens_hsa043201.54139940
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.45113928
20Selenocompound metabolism_Homo sapiens_hsa004501.44642448
21Non-homologous end-joining_Homo sapiens_hsa034501.42500095
22GABAergic synapse_Homo sapiens_hsa047271.39914216
23Circadian entrainment_Homo sapiens_hsa047131.37402269
24Glutamatergic synapse_Homo sapiens_hsa047241.37140611
25Fanconi anemia pathway_Homo sapiens_hsa034601.36037618
26Regulation of autophagy_Homo sapiens_hsa041401.35325652
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.31877334
28Tryptophan metabolism_Homo sapiens_hsa003801.31812357
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.26588047
30Serotonergic synapse_Homo sapiens_hsa047261.24411250
31Olfactory transduction_Homo sapiens_hsa047401.22610351
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.17789354
33Graft-versus-host disease_Homo sapiens_hsa053321.16403512
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.14868125
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.14222578
36Circadian rhythm_Homo sapiens_hsa047101.08512264
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.06655246
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03636162
39Homologous recombination_Homo sapiens_hsa034401.01940484
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.00107576
41Primary bile acid biosynthesis_Homo sapiens_hsa001200.99911701
42Autoimmune thyroid disease_Homo sapiens_hsa053200.98887630
43Renin secretion_Homo sapiens_hsa049240.96734983
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95776632
45Allograft rejection_Homo sapiens_hsa053300.93920223
46Calcium signaling pathway_Homo sapiens_hsa040200.93876812
47Basal transcription factors_Homo sapiens_hsa030220.93036254
48Dopaminergic synapse_Homo sapiens_hsa047280.91688877
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91254293
50Caffeine metabolism_Homo sapiens_hsa002320.90867168
51Salivary secretion_Homo sapiens_hsa049700.90480288
52Glycerophospholipid metabolism_Homo sapiens_hsa005640.88759493
53Type I diabetes mellitus_Homo sapiens_hsa049400.86608155
54Asthma_Homo sapiens_hsa053100.84909677
55Glycerolipid metabolism_Homo sapiens_hsa005610.81772678
56Jak-STAT signaling pathway_Homo sapiens_hsa046300.78038201
57Histidine metabolism_Homo sapiens_hsa003400.77562814
58Cholinergic synapse_Homo sapiens_hsa047250.77441336
59Long-term depression_Homo sapiens_hsa047300.77189793
60Amphetamine addiction_Homo sapiens_hsa050310.77150940
61Propanoate metabolism_Homo sapiens_hsa006400.76928051
62Arachidonic acid metabolism_Homo sapiens_hsa005900.75045333
63FoxO signaling pathway_Homo sapiens_hsa040680.74304460
64Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74191884
65Ovarian steroidogenesis_Homo sapiens_hsa049130.74004171
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73604388
67cAMP signaling pathway_Homo sapiens_hsa040240.72294556
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69556710
69Oxytocin signaling pathway_Homo sapiens_hsa049210.68677685
70Fatty acid biosynthesis_Homo sapiens_hsa000610.68052353
71Staphylococcus aureus infection_Homo sapiens_hsa051500.67664174
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67182517
73Sphingolipid metabolism_Homo sapiens_hsa006000.66667478
74Retinol metabolism_Homo sapiens_hsa008300.66426647
75Cocaine addiction_Homo sapiens_hsa050300.63845441
76Insulin secretion_Homo sapiens_hsa049110.63337404
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62332312
78Chemical carcinogenesis_Homo sapiens_hsa052040.61770744
79T cell receptor signaling pathway_Homo sapiens_hsa046600.61286509
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60872126
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59818920
82RNA degradation_Homo sapiens_hsa030180.59400249
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.59256312
84Type II diabetes mellitus_Homo sapiens_hsa049300.57591152
85Lysine degradation_Homo sapiens_hsa003100.56692339
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54992916
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53716700
88Osteoclast differentiation_Homo sapiens_hsa043800.50855475
89Hematopoietic cell lineage_Homo sapiens_hsa046400.50383202
90Platelet activation_Homo sapiens_hsa046110.50348167
91African trypanosomiasis_Homo sapiens_hsa051430.47800854
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47708757
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46504070
94Tuberculosis_Homo sapiens_hsa051520.45556055
95Collecting duct acid secretion_Homo sapiens_hsa049660.44997650
96Choline metabolism in cancer_Homo sapiens_hsa052310.44044353
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43886740
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43602472
99Measles_Homo sapiens_hsa051620.41891207
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.41219878

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