ZNF214

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.52988538
2nucleobase catabolic process (GO:0046113)5.13306432
3cilium movement (GO:0003341)4.93629229
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.89471096
5epithelial cilium movement (GO:0003351)4.87615589
6cilium or flagellum-dependent cell motility (GO:0001539)4.81962187
7intraciliary transport (GO:0042073)4.49099727
8axonemal dynein complex assembly (GO:0070286)4.25680922
9presynaptic membrane assembly (GO:0097105)4.09834881
10regulation of cilium movement (GO:0003352)3.93346952
11axoneme assembly (GO:0035082)3.86266236
12cilium morphogenesis (GO:0060271)3.75424188
13DNA double-strand break processing (GO:0000729)3.57413929
14cilium organization (GO:0044782)3.36922626
15photoreceptor cell maintenance (GO:0045494)3.32780066
16nonmotile primary cilium assembly (GO:0035058)3.32107431
17acrosome assembly (GO:0001675)3.31652619
18presynaptic membrane organization (GO:0097090)3.30864827
19cilium assembly (GO:0042384)3.29527832
20neural tube formation (GO:0001841)3.29049873
21left/right axis specification (GO:0070986)3.25770828
22retinal ganglion cell axon guidance (GO:0031290)3.23679521
23centriole replication (GO:0007099)3.17274864
24resolution of meiotic recombination intermediates (GO:0000712)3.12528237
25calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.10163563
26establishment of nucleus localization (GO:0040023)3.08123466
27retinal rod cell development (GO:0046548)3.04961132
28response to pheromone (GO:0019236)3.04041009
29limb bud formation (GO:0060174)3.00859336
30olfactory bulb development (GO:0021772)2.94746551
31positive regulation of mitochondrial fission (GO:0090141)2.94504293
32histone H2A acetylation (GO:0043968)2.92549584
33somite development (GO:0061053)2.90716486
34neuron projection extension involved in neuron projection guidance (GO:1902284)2.90519769
35axon extension involved in axon guidance (GO:0048846)2.90519769
36neuron cell-cell adhesion (GO:0007158)2.87676624
37head development (GO:0060322)2.87423775
38DNA damage response, detection of DNA damage (GO:0042769)2.87168967
39chromatin remodeling at centromere (GO:0031055)2.84325132
40CENP-A containing nucleosome assembly (GO:0034080)2.81534021
41protein polyglutamylation (GO:0018095)2.80116853
42vocalization behavior (GO:0071625)2.78192315
43smoothened signaling pathway (GO:0007224)2.77363612
44negative regulation of DNA recombination (GO:0045910)2.76035527
45double-strand break repair via nonhomologous end joining (GO:0006303)2.71359223
46non-recombinational repair (GO:0000726)2.71359223
47response to nitrosative stress (GO:0051409)2.71278689
48cellular component assembly involved in morphogenesis (GO:0010927)2.70194023
49neuron fate determination (GO:0048664)2.69956116
50DNA integration (GO:0015074)2.68465831
51microtubule depolymerization (GO:0007019)2.67273467
52negative regulation of transcription regulatory region DNA binding (GO:2000678)2.66203375
53synapsis (GO:0007129)2.62249947
54microtubule bundle formation (GO:0001578)2.61782166
55short-term memory (GO:0007614)2.59911426
56attachment of spindle microtubules to kinetochore (GO:0008608)2.58373768
57retinal cone cell development (GO:0046549)2.56395681
58regulation of feeding behavior (GO:0060259)2.56214778
59regulation of development, heterochronic (GO:0040034)2.56048334
60protein localization to cilium (GO:0061512)2.53474327
61regulation of meiosis I (GO:0060631)2.51767719
62left/right pattern formation (GO:0060972)2.49552206
63water-soluble vitamin biosynthetic process (GO:0042364)2.49507617
64brain morphogenesis (GO:0048854)2.48337986
65meiotic cell cycle (GO:0051321)2.47328018
66regulation of microtubule-based movement (GO:0060632)2.46750627
67histone exchange (GO:0043486)2.46615616
68positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.41776023
69positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.41776023
70positive regulation of mitotic sister chromatid separation (GO:1901970)2.41776023
71positive regulation of dendritic spine morphogenesis (GO:0061003)2.40168409
72ncRNA catabolic process (GO:0034661)2.39575874
73postsynaptic membrane organization (GO:0001941)2.37959617
74regulation of male gonad development (GO:2000018)2.37568419
75microtubule polymerization or depolymerization (GO:0031109)2.37305917
76determination of left/right symmetry (GO:0007368)2.37119016
77ventricular system development (GO:0021591)2.35639935
78determination of bilateral symmetry (GO:0009855)2.35443238
79regulation of timing of cell differentiation (GO:0048505)2.33630350
80transmission of nerve impulse (GO:0019226)2.33553667
81synapse assembly (GO:0007416)2.32346432
82centriole assembly (GO:0098534)2.32144396
83ubiquinone metabolic process (GO:0006743)2.31812959
84microtubule-based movement (GO:0007018)2.30474793
85sialylation (GO:0097503)2.30417443
86specification of symmetry (GO:0009799)2.30407018
87mitochondrial respiratory chain complex I assembly (GO:0032981)2.29132183
88NADH dehydrogenase complex assembly (GO:0010257)2.29132183
89mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.29132183
90cerebral cortex neuron differentiation (GO:0021895)2.29096022
91DNA ligation (GO:0006266)2.28600765
92piRNA metabolic process (GO:0034587)2.28449067
93lateral ventricle development (GO:0021670)2.27576319
94microtubule anchoring (GO:0034453)2.27574880
95pyrimidine dimer repair (GO:0006290)2.27553815
96establishment of tissue polarity (GO:0007164)2.27360346
97establishment of planar polarity (GO:0001736)2.27360346
98RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.26701434
99sperm motility (GO:0030317)2.26505071
100sequestering of actin monomers (GO:0042989)2.26426137

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.92127370
2ZNF274_21170338_ChIP-Seq_K562_Hela3.37200090
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.28632769
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.83814192
5TAF15_26573619_Chip-Seq_HEK293_Human2.80998989
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.78629732
7GBX2_23144817_ChIP-Seq_PC3_Human2.71976553
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.65722605
9FUS_26573619_Chip-Seq_HEK293_Human2.60925946
10IGF1R_20145208_ChIP-Seq_DFB_Human2.54732662
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.38962911
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36827037
13EWS_26573619_Chip-Seq_HEK293_Human2.35469539
14P300_19829295_ChIP-Seq_ESCs_Human2.22642718
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19894395
16VDR_22108803_ChIP-Seq_LS180_Human2.19639760
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.12010995
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.10789540
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.10416853
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.05252638
21AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.77857239
22RNF2_27304074_Chip-Seq_NSC_Mouse1.73502626
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.73159837
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.70877517
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70044376
26SMAD4_21799915_ChIP-Seq_A2780_Human1.69283680
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.68261287
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.66019298
29MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.65397156
30IRF1_19129219_ChIP-ChIP_H3396_Human1.64848282
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.62186674
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61821371
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61067563
34* STAT3_23295773_ChIP-Seq_U87_Human1.59462945
35KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.58776032
36* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58687135
37SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55890813
38TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54996306
39TP63_19390658_ChIP-ChIP_HaCaT_Human1.51937286
40CBP_20019798_ChIP-Seq_JUKART_Human1.50274028
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50274028
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.49733088
43MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46838247
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46765509
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44410205
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42970892
47RUNX2_22187159_ChIP-Seq_PCA_Human1.41983534
48GABP_17652178_ChIP-ChIP_JURKAT_Human1.38776534
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.38404357
50MYC_18940864_ChIP-ChIP_HL60_Human1.37315589
51ELK1_19687146_ChIP-ChIP_HELA_Human1.36971651
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36738226
53AR_25329375_ChIP-Seq_VCAP_Human1.32015470
54ER_23166858_ChIP-Seq_MCF-7_Human1.30960296
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30312645
56TCF4_23295773_ChIP-Seq_U87_Human1.27399046
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25802288
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21340493
59KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20244797
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19254889
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18671607
62EST1_17652178_ChIP-ChIP_JURKAT_Human1.18320097
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.16996252
64KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.16535756
65E2F4_17652178_ChIP-ChIP_JURKAT_Human1.15824204
66TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15618773
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14553932
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14553932
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12138122
70TCF4_22108803_ChIP-Seq_LS180_Human1.11886290
71SOX2_19829295_ChIP-Seq_ESCs_Human1.09732319
72NANOG_19829295_ChIP-Seq_ESCs_Human1.09732319
73E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.08542740
74TAL1_26923725_Chip-Seq_HPCs_Mouse1.07993539
75TBX3_20139965_ChIP-Seq_ESCs_Mouse1.07076280
76KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06856970
77TBX3_20139965_ChIP-Seq_MESCs_Mouse1.06807491
78SOX2_16153702_ChIP-ChIP_HESCs_Human1.06757269
79TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06644972
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05668786
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.05305961
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04890498
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04000326
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.03837565
85TP53_22573176_ChIP-Seq_HFKS_Human1.02929135
86JUN_21703547_ChIP-Seq_K562_Human1.02835170
87CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02689442
88GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01719162
89RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99697875
90SOX2_21211035_ChIP-Seq_LN229_Gbm0.99205453
91STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97339012
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95541797
93SOX9_26525672_Chip-Seq_HEART_Mouse0.93816264
94NFE2_27457419_Chip-Seq_LIVER_Mouse0.93549550
95BCAT_22108803_ChIP-Seq_LS180_Human0.92485769
96SMAD4_21741376_ChIP-Seq_EPCs_Human0.91617769
97KDM2B_26808549_Chip-Seq_REH_Human0.90062367
98BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.89431779
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87143111
100PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86810188

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008789_abnormal_olfactory_epithelium3.08956342
2MP0001529_abnormal_vocalization2.75511105
3MP0006292_abnormal_olfactory_placode2.72195342
4MP0008877_abnormal_DNA_methylation2.65698851
5MP0001984_abnormal_olfaction2.59711629
6MP0010030_abnormal_orbit_morphology2.57470151
7MP0005499_abnormal_olfactory_system2.54257178
8MP0005394_taste/olfaction_phenotype2.54257178
9MP0004133_heterotaxia2.52342293
10MP0002653_abnormal_ependyma_morphology2.51126672
11MP0003122_maternal_imprinting2.39735994
12MP0002102_abnormal_ear_morphology2.37670154
13MP0003880_abnormal_central_pattern2.23335849
14MP0001293_anophthalmia2.01125520
15MP0000778_abnormal_nervous_system1.98169948
16MP0002233_abnormal_nose_morphology1.95084663
17MP0005248_abnormal_Harderian_gland1.92184798
18MP0006072_abnormal_retinal_apoptosis1.88126919
19MP0003718_maternal_effect1.88069391
20MP0003937_abnormal_limbs/digits/tail_de1.79742397
21MP0000049_abnormal_middle_ear1.71007676
22MP0003121_genomic_imprinting1.66697428
23MP0002234_abnormal_pharynx_morphology1.64650523
24MP0002938_white_spotting1.63886032
25MP0000647_abnormal_sebaceous_gland1.60608111
26MP0000569_abnormal_digit_pigmentation1.56561469
27MP0002751_abnormal_autonomic_nervous1.55177324
28MP0000631_abnormal_neuroendocrine_gland1.52413477
29MP0003890_abnormal_embryonic-extraembry1.52173120
30MP0000383_abnormal_hair_follicle1.49416408
31MP0001486_abnormal_startle_reflex1.49356267
32MP0005551_abnormal_eye_electrophysiolog1.47789133
33MP0000566_synostosis1.47079235
34MP0008058_abnormal_DNA_repair1.46541129
35MP0005253_abnormal_eye_physiology1.44778505
36MP0003567_abnormal_fetal_cardiomyocyte1.36416872
37MP0005187_abnormal_penis_morphology1.34827757
38MP0001286_abnormal_eye_development1.33637123
39MP0006276_abnormal_autonomic_nervous1.33312410
40MP0002736_abnormal_nociception_after1.31578856
41MP0003119_abnormal_digestive_system1.25279344
42MP0003693_abnormal_embryo_hatching1.24779579
43MP0003755_abnormal_palate_morphology1.21260888
44MP0002928_abnormal_bile_duct1.20011844
45MP0001299_abnormal_eye_distance/1.19318950
46MP0002249_abnormal_larynx_morphology1.17832910
47MP0001324_abnormal_eye_pigmentation1.17276761
48MP0001177_atelectasis1.16662093
49MP0003861_abnormal_nervous_system1.16429013
50MP0003698_abnormal_male_reproductive1.15332467
51MP0000516_abnormal_urinary_system1.13559878
52MP0005367_renal/urinary_system_phenotyp1.13559878
53MP0001929_abnormal_gametogenesis1.13493207
54MP0000427_abnormal_hair_cycle1.13257016
55MP0003787_abnormal_imprinting1.07544505
56MP0002282_abnormal_trachea_morphology1.06986896
57MP0002210_abnormal_sex_determination1.06870585
58MP0001485_abnormal_pinna_reflex1.06383830
59MP0010678_abnormal_skin_adnexa1.05468967
60MP0000026_abnormal_inner_ear1.04930863
61MP0004859_abnormal_synaptic_plasticity1.03320224
62MP0002152_abnormal_brain_morphology1.02658540
63MP0002734_abnormal_mechanical_nocicepti1.02293670
64MP0002752_abnormal_somatic_nervous1.00028018
65MP0005391_vision/eye_phenotype0.98902167
66MP0003938_abnormal_ear_development0.96638699
67MP0005645_abnormal_hypothalamus_physiol0.95851361
68MP0002160_abnormal_reproductive_system0.95801664
69MP0001968_abnormal_touch/_nociception0.95677285
70MP0000955_abnormal_spinal_cord0.95264776
71MP0000534_abnormal_ureter_morphology0.95207537
72MP0000653_abnormal_sex_gland0.92929639
73MP0005195_abnormal_posterior_eye0.91820016
74MP0002697_abnormal_eye_size0.90105307
75MP0002184_abnormal_innervation0.89755376
76MP0001145_abnormal_male_reproductive0.89440623
77MP0004270_analgesia0.89374587
78MP0002116_abnormal_craniofacial_bone0.88795236
79MP0001963_abnormal_hearing_physiology0.88381118
80MP0001188_hyperpigmentation0.87384927
81MP0009697_abnormal_copulation0.87198005
82MP0010094_abnormal_chromosome_stability0.87086999
83MP0002111_abnormal_tail_morphology0.86924655
84MP0002067_abnormal_sensory_capabilities0.86624956
85MP0005395_other_phenotype0.84386025
86MP0003935_abnormal_craniofacial_develop0.84218194
87MP0002822_catalepsy0.84002798
88MP0002882_abnormal_neuron_morphology0.81574345
89MP0002084_abnormal_developmental_patter0.81382589
90MP0005410_abnormal_fertilization0.80148248
91MP0002572_abnormal_emotion/affect_behav0.79250210
92MP0008995_early_reproductive_senescence0.78860478
93MP0009745_abnormal_behavioral_response0.78674590
94MP0008932_abnormal_embryonic_tissue0.78635787
95MP0003136_yellow_coat_color0.78448415
96MP0002177_abnormal_outer_ear0.77963701
97MP0002272_abnormal_nervous_system0.76994783
98MP0005646_abnormal_pituitary_gland0.76699912
99MP0002557_abnormal_social/conspecific_i0.75064335
100MP0002085_abnormal_embryonic_tissue0.74777600

Predicted human phenotypes

RankGene SetZ-score
1True hermaphroditism (HP:0010459)4.90729039
2Pancreatic fibrosis (HP:0100732)4.56944611
3Chronic hepatic failure (HP:0100626)4.27176277
4Abnormality of midbrain morphology (HP:0002418)4.22727284
5Molar tooth sign on MRI (HP:0002419)4.22727284
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.92787829
7Pancreatic cysts (HP:0001737)3.86654374
8Abnormal ciliary motility (HP:0012262)3.71845002
9Nephronophthisis (HP:0000090)3.71624856
10Abnormal respiratory motile cilium physiology (HP:0012261)3.54377726
11Supernumerary spleens (HP:0009799)3.49903441
12Aplasia/Hypoplasia of the tongue (HP:0010295)3.42142456
13Abnormal respiratory motile cilium morphology (HP:0005938)3.40123412
14Abnormal respiratory epithelium morphology (HP:0012253)3.40123412
15Medial flaring of the eyebrow (HP:0010747)3.34455248
16Gait imbalance (HP:0002141)3.23595374
17Congenital primary aphakia (HP:0007707)3.18822292
18Occipital encephalocele (HP:0002085)3.15947172
19Cystic liver disease (HP:0006706)3.10666125
20Abnormality of the renal medulla (HP:0100957)3.10570300
21Rhinitis (HP:0012384)3.10199853
22Chronic bronchitis (HP:0004469)3.04717885
23Dynein arm defect of respiratory motile cilia (HP:0012255)2.95844924
24Absent/shortened dynein arms (HP:0200106)2.95844924
25Abnormality of the labia minora (HP:0012880)2.89561203
26Abdominal situs inversus (HP:0003363)2.89425376
27Abnormality of abdominal situs (HP:0011620)2.89425376
28Colon cancer (HP:0003003)2.88514008
29Postaxial foot polydactyly (HP:0001830)2.86815653
30Bile duct proliferation (HP:0001408)2.82924524
31Abnormal biliary tract physiology (HP:0012439)2.82924524
32Postaxial hand polydactyly (HP:0001162)2.82537368
33Nephrogenic diabetes insipidus (HP:0009806)2.75422504
34Bifid tongue (HP:0010297)2.75062693
35Genital tract atresia (HP:0001827)2.74198029
36Hyperglycinemia (HP:0002154)2.63083893
37Congenital hepatic fibrosis (HP:0002612)2.62541196
38Median cleft lip (HP:0000161)2.60521939
39Vaginal atresia (HP:0000148)2.58626299
40Tubulointerstitial nephritis (HP:0001970)2.56422303
41Preaxial hand polydactyly (HP:0001177)2.56225855
42Anencephaly (HP:0002323)2.54731427
43Narrow forehead (HP:0000341)2.50399843
44Sclerocornea (HP:0000647)2.49875141
45Oculomotor apraxia (HP:0000657)2.34472675
46Aplasia/Hypoplasia of the tibia (HP:0005772)2.33324146
47Poor coordination (HP:0002370)2.31337128
48Short tibia (HP:0005736)2.30613903
49Volvulus (HP:0002580)2.15946090
50Shoulder girdle muscle weakness (HP:0003547)2.15659320
51Neonatal respiratory distress (HP:0002643)2.13249395
52Hepatoblastoma (HP:0002884)2.12949173
53Septo-optic dysplasia (HP:0100842)2.12793903
54Male pseudohermaphroditism (HP:0000037)2.08204985
55Broad foot (HP:0001769)2.08066276
56Methylmalonic acidemia (HP:0002912)2.07102726
57Optic nerve hypoplasia (HP:0000609)2.03974402
58Amyotrophic lateral sclerosis (HP:0007354)1.99002607
59Bronchiectasis (HP:0002110)1.91335282
60Aganglionic megacolon (HP:0002251)1.86436795
61Thyroid-stimulating hormone excess (HP:0002925)1.85307704
62Prominent nasal bridge (HP:0000426)1.84436915
63Optic nerve coloboma (HP:0000588)1.84303186
64Furrowed tongue (HP:0000221)1.82245872
65Aplasia/Hypoplasia of the sternum (HP:0006714)1.81686996
66Anophthalmia (HP:0000528)1.81310519
67High anterior hairline (HP:0009890)1.79538765
68Dandy-Walker malformation (HP:0001305)1.79341389
69Drooling (HP:0002307)1.78752156
70Abnormality of glycine metabolism (HP:0010895)1.78458190
71Abnormality of serine family amino acid metabolism (HP:0010894)1.78458190
72Oligodactyly (hands) (HP:0001180)1.78345054
73Abnormality of the hip-girdle musculature (HP:0001445)1.77843348
74Abnormality of the musculature of the pelvis (HP:0001469)1.77843348
75Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74972272
76Multicystic kidney dysplasia (HP:0000003)1.74947880
77Aplasia/Hypoplasia of the lens (HP:0008063)1.71560248
78Asplenia (HP:0001746)1.70939785
79Astigmatism (HP:0000483)1.70571396
80Micropenis (HP:0000054)1.69508268
81Specific learning disability (HP:0001328)1.69503848
82Abnormality of the metopic suture (HP:0005556)1.69438491
83Progressive inability to walk (HP:0002505)1.68608021
84Sloping forehead (HP:0000340)1.68144952
85Abnormal lung lobation (HP:0002101)1.67977373
86Hyperactive renin-angiotensin system (HP:0000841)1.67705841
87Aplasia/Hypoplasia of the spleen (HP:0010451)1.67051008
88Hyperventilation (HP:0002883)1.63916199
89Gaze-evoked nystagmus (HP:0000640)1.63287324
90Aplasia/Hypoplasia of the uvula (HP:0010293)1.59277196
91Intestinal atresia (HP:0011100)1.58699161
92Highly arched eyebrow (HP:0002553)1.58288157
93Tubulointerstitial abnormality (HP:0001969)1.58038056
94Decreased testicular size (HP:0008734)1.57219756
95Tubular atrophy (HP:0000092)1.56808065
96Focal motor seizures (HP:0011153)1.55401715
97Biliary tract neoplasm (HP:0100574)1.55063375
98Urinary urgency (HP:0000012)1.54707815
99Chorioretinal coloboma (HP:0000567)1.54572854
100Progressive cerebellar ataxia (HP:0002073)1.54320169

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.81355691
2WNK33.43207318
3BCR3.13173408
4MAP3K42.83810879
5TNIK2.72529083
6MARK12.50218204
7TSSK62.26175614
8EPHA42.25798642
9MAP2K72.21971841
10BMPR1B2.15083272
11ERBB32.14591552
12SRPK12.06021038
13BRSK21.94994070
14PNCK1.89573853
15MKNK11.88901446
16MAPK151.87560415
17MAP4K21.87516486
18CASK1.81372037
19FRK1.79605730
20DYRK31.64149630
21PLK31.63852330
22TTK1.55034893
23CDK191.50287289
24MKNK21.47759629
25ACVR1B1.42544455
26NTRK21.39609633
27DYRK21.36491779
28PLK41.32292337
29CSNK1G11.29563510
30EIF2AK31.28435569
31NEK11.27210377
32MAPK131.25349522
33CSNK1G21.18482848
34PLK11.16264870
35DYRK1B1.15402106
36CSNK1A1L1.13258821
37CSNK1G31.12842880
38RPS6KA41.06554102
39ZAK1.04045910
40VRK11.03318753
41STK161.01912967
42PLK21.00237256
43BUB10.98552171
44PINK10.96485771
45BRSK10.95993058
46DYRK1A0.93308916
47CDC70.93002512
48EPHB20.88666232
49PAK30.88569240
50PKN10.87514355
51MINK10.87143675
52NEK20.80559766
53TGFBR10.78794753
54YES10.76101414
55STK38L0.75744838
56PBK0.74328016
57MET0.72247591
58PRKCE0.71723552
59MAP2K40.70803233
60GRK10.70781610
61STK390.69219542
62NUAK10.68225364
63BRD40.63599179
64INSRR0.58670498
65ADRBK20.58668298
66PRKCG0.54856582
67CHEK20.53539767
68CAMKK20.53046766
69CAMK2A0.53044968
70AKT30.51763963
71OXSR10.50270336
72WNK40.49831130
73WEE10.48574154
74SIK30.48213082
75PTK2B0.47934254
76ATM0.47179698
77FGFR10.46371838
78PASK0.45501725
79TIE10.45425078
80FGFR20.45417133
81AURKB0.44788614
82FLT30.43703418
83CDK90.42216911
84CDK50.41876846
85CHEK10.41587605
86ATR0.41097440
87LATS10.39530447
88CDK30.37715344
89CAMK1G0.37188213
90SGK20.36306144
91MAP3K70.36203376
92CDK10.36149627
93CDK180.35435979
94PRKACB0.35014196
95PRKACA0.34947927
96CSNK1D0.34262519
97CAMK40.33441626
98NLK0.33260376
99PRKCZ0.33034987
100CSNK1E0.32270131

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.21863816
2Basal transcription factors_Homo sapiens_hsa030222.62385545
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.48838364
4Propanoate metabolism_Homo sapiens_hsa006402.45676714
5Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.41810537
6Protein export_Homo sapiens_hsa030602.23912054
7Non-homologous end-joining_Homo sapiens_hsa034502.10005815
8Fanconi anemia pathway_Homo sapiens_hsa034602.00284026
9Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.97885785
10Steroid biosynthesis_Homo sapiens_hsa001001.94041694
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.90885093
12RNA degradation_Homo sapiens_hsa030181.85024911
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.74797350
14Butanoate metabolism_Homo sapiens_hsa006501.70505903
15Phototransduction_Homo sapiens_hsa047441.65937868
16Mismatch repair_Homo sapiens_hsa034301.64671362
17beta-Alanine metabolism_Homo sapiens_hsa004101.63122963
18Nicotine addiction_Homo sapiens_hsa050331.62013938
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.61629983
20Homologous recombination_Homo sapiens_hsa034401.53240723
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.53086648
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.49829862
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.48850274
24Base excision repair_Homo sapiens_hsa034101.45542325
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.39631211
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.38600470
27RNA transport_Homo sapiens_hsa030131.38598598
28Taste transduction_Homo sapiens_hsa047421.36909788
29Huntingtons disease_Homo sapiens_hsa050161.30462516
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25418813
31Nucleotide excision repair_Homo sapiens_hsa034201.21757650
32Olfactory transduction_Homo sapiens_hsa047401.20606410
33Cell cycle_Homo sapiens_hsa041101.16090060
34Oocyte meiosis_Homo sapiens_hsa041141.12974934
35Axon guidance_Homo sapiens_hsa043601.12173998
36Linoleic acid metabolism_Homo sapiens_hsa005911.11469155
37Circadian rhythm_Homo sapiens_hsa047101.09090111
38Basal cell carcinoma_Homo sapiens_hsa052171.07635538
39Caffeine metabolism_Homo sapiens_hsa002321.07120682
40Hedgehog signaling pathway_Homo sapiens_hsa043401.06196054
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05880166
42Peroxisome_Homo sapiens_hsa041461.05666402
43Spliceosome_Homo sapiens_hsa030401.01998599
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.00850173
45RNA polymerase_Homo sapiens_hsa030201.00360830
46Oxidative phosphorylation_Homo sapiens_hsa001900.98556679
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97660780
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97550923
49Vitamin B6 metabolism_Homo sapiens_hsa007500.96157399
50Hippo signaling pathway_Homo sapiens_hsa043900.94721442
51Tryptophan metabolism_Homo sapiens_hsa003800.93504073
52Fatty acid elongation_Homo sapiens_hsa000620.92890539
53Parkinsons disease_Homo sapiens_hsa050120.91690754
54Regulation of autophagy_Homo sapiens_hsa041400.91025467
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90921005
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87403337
57Retinol metabolism_Homo sapiens_hsa008300.87219717
58Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.87068325
59GABAergic synapse_Homo sapiens_hsa047270.86057824
60Chemical carcinogenesis_Homo sapiens_hsa052040.86001985
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82791087
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82450319
63Nitrogen metabolism_Homo sapiens_hsa009100.80392725
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79753331
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77767948
66Fatty acid degradation_Homo sapiens_hsa000710.77293221
67Pyrimidine metabolism_Homo sapiens_hsa002400.76579192
68Pyruvate metabolism_Homo sapiens_hsa006200.76159042
69TGF-beta signaling pathway_Homo sapiens_hsa043500.73598117
70Arginine and proline metabolism_Homo sapiens_hsa003300.71487425
71Selenocompound metabolism_Homo sapiens_hsa004500.71004134
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66814515
73Metabolic pathways_Homo sapiens_hsa011000.66256781
74ABC transporters_Homo sapiens_hsa020100.65334168
75Ether lipid metabolism_Homo sapiens_hsa005650.64124691
76Serotonergic synapse_Homo sapiens_hsa047260.63790768
77Fatty acid metabolism_Homo sapiens_hsa012120.63761250
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62957433
79mRNA surveillance pathway_Homo sapiens_hsa030150.62357050
80DNA replication_Homo sapiens_hsa030300.62255025
81Morphine addiction_Homo sapiens_hsa050320.60889832
82Dopaminergic synapse_Homo sapiens_hsa047280.60429104
83Histidine metabolism_Homo sapiens_hsa003400.60230534
84Circadian entrainment_Homo sapiens_hsa047130.59715807
85Wnt signaling pathway_Homo sapiens_hsa043100.59205239
86Tight junction_Homo sapiens_hsa045300.58433870
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57070710
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56496011
89Purine metabolism_Homo sapiens_hsa002300.56026477
90Biosynthesis of amino acids_Homo sapiens_hsa012300.53975965
91Carbon metabolism_Homo sapiens_hsa012000.52290058
92Glutamatergic synapse_Homo sapiens_hsa047240.50803994
93Tyrosine metabolism_Homo sapiens_hsa003500.50012278
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47974616
95Lysine degradation_Homo sapiens_hsa003100.47329474
96Cocaine addiction_Homo sapiens_hsa050300.46210171
97Insulin secretion_Homo sapiens_hsa049110.45559383
98p53 signaling pathway_Homo sapiens_hsa041150.44145595
99Alcoholism_Homo sapiens_hsa050340.44132292
100Folate biosynthesis_Homo sapiens_hsa007900.42929153

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