ZNF213

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: C2H2 zinc finger proteins, such as ZNF213, have bipartite structures in which one domain binds DNA or RNA and the other modulates target gene expression. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell migration in hindbrain (GO:0021535)4.23317139
2synaptic vesicle exocytosis (GO:0016079)3.66680146
3acrosome reaction (GO:0007340)3.66188811
4positive regulation of histone deacetylation (GO:0031065)3.60959275
5phosphatidylethanolamine biosynthetic process (GO:0006646)3.52383494
6establishment of mitochondrion localization (GO:0051654)3.44147583
7positive regulation of CREB transcription factor activity (GO:0032793)3.43246496
8sperm capacitation (GO:0048240)3.40025398
9regulation of synapse structural plasticity (GO:0051823)3.37694515
10behavioral response to nicotine (GO:0035095)3.34837230
11postsynaptic membrane organization (GO:0001941)3.30282240
12sperm motility (GO:0030317)3.29832187
13negative regulation of cAMP-mediated signaling (GO:0043951)3.23228517
14phosphatidylethanolamine metabolic process (GO:0046337)3.18798011
15positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.11196306
16establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.10675075
17mitochondrion transport along microtubule (GO:0047497)3.10675075
18response to pheromone (GO:0019236)3.07569053
19negative regulation of Rho protein signal transduction (GO:0035024)3.07383571
20GDP-mannose metabolic process (GO:0019673)3.05699693
21cellular response to ATP (GO:0071318)3.00832804
22regulation of ARF GTPase activity (GO:0032312)2.96469499
23positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.91305925
24amyloid precursor protein catabolic process (GO:0042987)2.88095182
25adenosine receptor signaling pathway (GO:0001973)2.85174301
26microtubule severing (GO:0051013)2.84127706
27negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.83262372
28protein insertion into membrane (GO:0051205)2.79173975
29positive regulation of triglyceride biosynthetic process (GO:0010867)2.78788515
30response to acidic pH (GO:0010447)2.77977742
31intracellular estrogen receptor signaling pathway (GO:0030520)2.77321577
32calcium ion-dependent exocytosis (GO:0017156)2.76239054
33dendritic spine morphogenesis (GO:0060997)2.66011877
34positive regulation of protein deacetylation (GO:0090312)2.65624303
35positive regulation of synapse maturation (GO:0090129)2.65166183
36RNA destabilization (GO:0050779)2.60875990
37negative regulation of tumor necrosis factor production (GO:0032720)2.59782867
38opioid receptor signaling pathway (GO:0038003)2.58762387
39spermatid development (GO:0007286)2.57690180
40negative regulation of telomere maintenance (GO:0032205)2.56978329
41neuromuscular synaptic transmission (GO:0007274)2.55841772
42histone H4 deacetylation (GO:0070933)2.55707811
43synaptic vesicle endocytosis (GO:0048488)2.54936674
44negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.54055444
45synaptic vesicle docking involved in exocytosis (GO:0016081)2.52833701
46purinergic nucleotide receptor signaling pathway (GO:0035590)2.52817977
47negative regulation of erythrocyte differentiation (GO:0045647)2.52183639
48urinary tract smooth muscle contraction (GO:0014848)2.52074616
49ionotropic glutamate receptor signaling pathway (GO:0035235)2.51530052
50RNA localization (GO:0006403)2.48998002
51regulation of cilium assembly (GO:1902017)2.47462384
52synaptic vesicle maturation (GO:0016188)2.47342690
53cell-cell junction maintenance (GO:0045217)2.45477229
54positive regulation of protein sumoylation (GO:0033235)2.45413372
55ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.44509189
56regulation of protein kinase A signaling (GO:0010738)2.44255360
57detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.43737459
58detection of temperature stimulus involved in sensory perception (GO:0050961)2.43737459
59regulation of hydrogen peroxide metabolic process (GO:0010310)2.42222545
60negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.41960203
61positive regulation of T cell apoptotic process (GO:0070234)2.41880397
62glycine transport (GO:0015816)2.41877827
63glutamate secretion (GO:0014047)2.41566475
64cell wall macromolecule metabolic process (GO:0044036)2.41440553
65regulation of synapse maturation (GO:0090128)2.39754470
66cornea development in camera-type eye (GO:0061303)2.39458289
67regulation of histone deacetylation (GO:0031063)2.38027120
68negative regulation of cell size (GO:0045792)2.36567283
69cellular response to pH (GO:0071467)2.36211419
70histone H3 deacetylation (GO:0070932)2.35547956
71regulation of actin nucleation (GO:0051125)2.34976351
72regulation of interferon-beta biosynthetic process (GO:0045357)2.34748645
73positive regulation of lymphocyte apoptotic process (GO:0070230)2.34631655
74mitochondrion localization (GO:0051646)2.34033504
75G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.32671803
76regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.32127666
77purinergic receptor signaling pathway (GO:0035587)2.31293321
78regulation of skeletal muscle contraction (GO:0014819)2.31266086
79peptidyl-tyrosine autophosphorylation (GO:0038083)2.31238361
80synaptic transmission, glutamatergic (GO:0035249)2.31192949
81regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.30865357
82multicellular organism reproduction (GO:0032504)2.30107492
83UV protection (GO:0009650)2.29861506
84cranial nerve morphogenesis (GO:0021602)2.29574779
85regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.29560442
86dendritic spine organization (GO:0097061)2.29415221
87positive regulation of protein kinase C signaling (GO:0090037)2.29393282
88amino sugar catabolic process (GO:0046348)2.28333499
89membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.27778604
90regulation of respiratory system process (GO:0044065)2.27467448
91regulation of Rab GTPase activity (GO:0032313)2.26740888
92positive regulation of Rab GTPase activity (GO:0032851)2.26740888
93negative regulation of cell aging (GO:0090344)2.26562822
94detection of light stimulus involved in visual perception (GO:0050908)2.26090620
95detection of light stimulus involved in sensory perception (GO:0050962)2.26090620
96positive regulation of protein homooligomerization (GO:0032464)2.24454661
97CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.23921068
98regulation of glycogen (starch) synthase activity (GO:2000465)2.22452111
99protein polyglutamylation (GO:0018095)2.21257176
100response to peptidoglycan (GO:0032494)2.20293133

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.70754334
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.62970045
3LXR_22292898_ChIP-Seq_THP-1_Human3.12232153
4VDR_21846776_ChIP-Seq_THP-1_Human2.90420920
5P68_20966046_ChIP-Seq_HELA_Human2.72295577
6CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.56910358
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.51381705
8EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.47494772
9* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.35261293
10BCL6_27268052_Chip-Seq_Bcells_Human2.26329511
11* KDM2B_26808549_Chip-Seq_DND41_Human2.25443317
12TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.20551871
13CTCF_27219007_Chip-Seq_Bcells_Human2.19675886
14DROSHA_22980978_ChIP-Seq_HELA_Human2.11889285
15* BCOR_27268052_Chip-Seq_Bcells_Human2.10389021
16TET1_21451524_ChIP-Seq_MESCs_Mouse2.06492453
17SMC4_20622854_ChIP-Seq_HELA_Human2.06414233
18ELF1_20517297_ChIP-Seq_JURKAT_Human2.06096216
19ERG_21242973_ChIP-ChIP_JURKAT_Human2.05192784
20RACK7_27058665_Chip-Seq_MCF-7_Human2.01635007
21* E2F1_20622854_ChIP-Seq_HELA_Human1.97698826
22* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.96513401
23SA1_27219007_Chip-Seq_ERYTHROID_Human1.95924152
24DNAJC2_21179169_ChIP-ChIP_NT2_Human1.95736094
25PHF8_20622854_ChIP-Seq_HELA_Human1.91456005
26SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.87928903
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.87097998
28* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.85694071
29* KDM2B_26808549_Chip-Seq_K562_Human1.81974930
30CTCF_27219007_Chip-Seq_ERYTHROID_Human1.81411732
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.78564180
32MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.76905034
33MAF_26560356_Chip-Seq_TH2_Human1.72941945
34CREB1_26743006_Chip-Seq_LNCaP_Human1.68152187
35EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.64276273
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63882410
37SA1_27219007_Chip-Seq_Bcells_Human1.63416478
38SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.61598055
39ELK3_25401928_ChIP-Seq_HUVEC_Human1.61324614
40ERA_21632823_ChIP-Seq_H3396_Human1.60879260
41* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.60394234
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.59664310
43CTCF_20526341_ChIP-Seq_ESCs_Human1.59474793
44TCF7_22412390_ChIP-Seq_EML_Mouse1.59212017
45SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.58214867
46YY1_22570637_ChIP-Seq_MALME-3M_Human1.53378054
47OCT4_19829295_ChIP-Seq_ESCs_Human1.52279582
48RARB_24833708_ChIP-Seq_LIVER_Mouse1.48220699
49FOXP1_21924763_ChIP-Seq_HESCs_Human1.48076327
50CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.46627041
51RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.46361028
52EZH2_22144423_ChIP-Seq_EOC_Human1.44684359
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44023247
54MYC_22102868_ChIP-Seq_BL_Human1.43153722
55UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.41908355
56JARID2_20075857_ChIP-Seq_MESCs_Mouse1.41640696
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.40351402
58RARG_19884340_ChIP-ChIP_MEFs_Mouse1.39058470
59* TP63_22573176_ChIP-Seq_HFKS_Human1.38317328
60TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.36117730
61* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.35884403
62VDR_24763502_ChIP-Seq_THP-1_Human1.35807752
63MAF_26560356_Chip-Seq_TH1_Human1.34416927
64RARA_24833708_ChIP-Seq_LIVER_Mouse1.33275834
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28987931
66* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.28576300
67CTCF_21964334_Chip-Seq_Bcells_Human1.28364475
68KDM2B_26808549_Chip-Seq_JURKAT_Human1.28341105
69GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28064484
70TP53_22127205_ChIP-Seq_IMR90_Human1.27985485
71ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27062025
72UTX_26944678_Chip-Seq_JUKART_Human1.26668142
73RARB_27405468_Chip-Seq_BRAIN_Mouse1.25541695
74SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.23900301
75CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.23850172
76RAC3_21632823_ChIP-Seq_H3396_Human1.22502182
77CTCF_26484167_Chip-Seq_Bcells_Mouse1.20826665
78RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.18499328
79P300_27268052_Chip-Seq_Bcells_Human1.17892616
80REST_18959480_ChIP-ChIP_MESCs_Mouse1.17844971
81PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.16818200
82MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.15537598
83CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15012961
84REST_21632747_ChIP-Seq_MESCs_Mouse1.14864464
85TET1_21490601_ChIP-Seq_MESCs_Mouse1.13227902
86KLF4_19829295_ChIP-Seq_ESCs_Human1.12550107
87ETS1_21867929_ChIP-Seq_TH2_Mouse1.11168791
88* RUNX1_27514584_Chip-Seq_MCF-7_Human1.10891284
89OCT4_20526341_ChIP-Seq_ESCs_Human1.09849673
90PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09470315
91JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.09077203
92SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08582743
93P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.06626108
94PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03354072
95RNF2_27304074_Chip-Seq_ESCs_Mouse1.02496326
96SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01458559
97GATA1_19941827_ChIP-Seq_MEL_Mouse1.01315312
98SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.01129312
99TAF2_19829295_ChIP-Seq_ESCs_Human1.00815470
100FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00541321

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005423_abnormal_somatic_nervous3.77910167
2MP0004859_abnormal_synaptic_plasticity3.25786205
3MP0001986_abnormal_taste_sensitivity2.90934154
4MP0002653_abnormal_ependyma_morphology2.73963364
5MP0005171_absent_coat_pigmentation2.73236832
6MP0001968_abnormal_touch/_nociception2.68936761
7MP0005410_abnormal_fertilization2.66769404
8MP0005174_abnormal_tail_pigmentation2.52144275
9MP0002822_catalepsy2.43021514
10MP0001348_abnormal_lacrimal_gland2.38321801
11MP0003878_abnormal_ear_physiology2.33298321
12MP0005377_hearing/vestibular/ear_phenot2.33298321
13MP0004381_abnormal_hair_follicle2.29087327
14MP0000678_abnormal_parathyroid_gland2.26056459
15MP0003880_abnormal_central_pattern2.21853256
16MP0002249_abnormal_larynx_morphology2.20828600
17MP0003136_yellow_coat_color2.19671528
18MP0003635_abnormal_synaptic_transmissio2.06544784
19MP0000015_abnormal_ear_pigmentation2.04242269
20MP0003172_abnormal_lysosome_physiology2.02579869
21MP0001502_abnormal_circadian_rhythm1.97066224
22MP0009278_abnormal_bone_marrow1.96678131
23MP0001188_hyperpigmentation1.80979297
24MP0005083_abnormal_biliary_tract1.71259896
25MP0002064_seizures1.69728835
26MP0002735_abnormal_chemical_nociception1.68706372
27MP0002063_abnormal_learning/memory/cond1.63835225
28MP0002736_abnormal_nociception_after1.58168005
29MP0001970_abnormal_pain_threshold1.54583731
30MP0005409_darkened_coat_color1.51903754
31MP0009745_abnormal_behavioral_response1.51238079
32MP0005670_abnormal_white_adipose1.48055491
33MP0004270_analgesia1.45607558
34MP0005076_abnormal_cell_differentiation1.40237755
35MP0002572_abnormal_emotion/affect_behav1.39328738
36MP0002734_abnormal_mechanical_nocicepti1.33820314
37MP0004130_abnormal_muscle_cell1.31241069
38MP0004858_abnormal_nervous_system1.30733461
39MP0002638_abnormal_pupillary_reflex1.29811456
40MP0001486_abnormal_startle_reflex1.29390822
41MP0002733_abnormal_thermal_nociception1.29309193
42MP0005551_abnormal_eye_electrophysiolog1.29246748
43MP0003436_decreased_susceptibility_to1.27729707
44MP0003183_abnormal_peptide_metabolism1.27270691
45MP0003698_abnormal_male_reproductive1.25819672
46MP0003879_abnormal_hair_cell1.25441108
47MP0004043_abnormal_pH_regulation1.21349035
48MP0003303_peritoneal_inflammation1.14584783
49MP0002272_abnormal_nervous_system1.13725869
50MP0000750_abnormal_muscle_regeneration1.13602522
51MP0001765_abnormal_ion_homeostasis1.12328506
52MP0000751_myopathy1.11270797
53MP0000538_abnormal_urinary_bladder1.07624010
54MP0000778_abnormal_nervous_system1.06533057
55MP0005645_abnormal_hypothalamus_physiol1.05218539
56MP0001905_abnormal_dopamine_level0.99163367
57MP0001873_stomach_inflammation0.97940525
58MP0000026_abnormal_inner_ear0.97936322
59MP0005646_abnormal_pituitary_gland0.95801714
60MP0002882_abnormal_neuron_morphology0.94313024
61MP0002277_abnormal_respiratory_mucosa0.94087618
62MP0008569_lethality_at_weaning0.93764483
63MP0003646_muscle_fatigue0.93038429
64MP0002557_abnormal_social/conspecific_i0.92644642
65MP0000955_abnormal_spinal_cord0.91108775
66MP0000681_abnormal_thyroid_gland0.90271100
67MP0005058_abnormal_lysosome_morphology0.89741699
68MP0000003_abnormal_adipose_tissue0.89688934
69MP0003137_abnormal_impulse_conducting0.89496260
70MP0008260_abnormal_autophagy0.85681434
71MP0004133_heterotaxia0.83906733
72MP0000470_abnormal_stomach_morphology0.82850904
73MP0009840_abnormal_foam_cell0.80586222
74MP0002067_abnormal_sensory_capabilities0.80410807
75MP0005499_abnormal_olfactory_system0.79626700
76MP0005394_taste/olfaction_phenotype0.79626700
77MP0005310_abnormal_salivary_gland0.75929347
78MP0001664_abnormal_digestion0.75924430
79MP0003329_amyloid_beta_deposits0.75866483
80MP0000516_abnormal_urinary_system0.75022683
81MP0005367_renal/urinary_system_phenotyp0.75022683
82MP0008872_abnormal_physiological_respon0.73694428
83MP0001963_abnormal_hearing_physiology0.73048025
84MP0008874_decreased_physiological_sensi0.72922327
85MP0002229_neurodegeneration0.72283663
86MP0004811_abnormal_neuron_physiology0.71598704
87MP0002066_abnormal_motor_capabilities/c0.70951851
88MP0002152_abnormal_brain_morphology0.70840494
89MP0001929_abnormal_gametogenesis0.70008443
90MP0003787_abnormal_imprinting0.69994784
91MP0002909_abnormal_adrenal_gland0.69551484
92MP0002751_abnormal_autonomic_nervous0.68071613
93MP0008789_abnormal_olfactory_epithelium0.61765812
94MP0000747_muscle_weakness0.61432301
95MP0005375_adipose_tissue_phenotype0.61417687
96MP0002752_abnormal_somatic_nervous0.61035396
97MP0001270_distended_abdomen0.60538879
98MP0002184_abnormal_innervation0.59433586
99MP0004885_abnormal_endolymph0.58134333
100MP0000013_abnormal_adipose_tissue0.57784975

Predicted human phenotypes

RankGene SetZ-score
1Attenuation of retinal blood vessels (HP:0007843)4.15582012
2Rib fusion (HP:0000902)3.78801248
3Severe visual impairment (HP:0001141)3.61483427
4Annular pancreas (HP:0001734)3.36781122
5Testicular atrophy (HP:0000029)3.31457426
6Akinesia (HP:0002304)3.28896015
7Bony spicule pigmentary retinopathy (HP:0007737)3.21680996
8Type II lissencephaly (HP:0007260)3.06949701
9Cerebellar dysplasia (HP:0007033)2.90645953
10Thin bony cortex (HP:0002753)2.90170909
11Congenital stationary night blindness (HP:0007642)2.88975169
12Hyperthyroidism (HP:0000836)2.84209225
13Hypochromic anemia (HP:0001931)2.83353196
14Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.81484993
15Abnormality of the aortic arch (HP:0012303)2.77745667
16Easy fatigability (HP:0003388)2.77593739
17Obstructive sleep apnea (HP:0002870)2.72251424
18Ankle clonus (HP:0011448)2.68885720
19Poikiloderma (HP:0001029)2.66390624
20Increased neuronal autofluorescent lipopigment (HP:0002074)2.59659153
21Decreased electroretinogram (ERG) amplitude (HP:0000654)2.56973485
22Stridor (HP:0010307)2.56347281
23Mesangial abnormality (HP:0001966)2.49040674
24Myokymia (HP:0002411)2.48379810
25Myopathic facies (HP:0002058)2.47553212
26Squamous cell carcinoma (HP:0002860)2.47070398
27Abnormal rod and cone electroretinograms (HP:0008323)2.44698487
28Progressive microcephaly (HP:0000253)2.40447000
29Hypochromic microcytic anemia (HP:0004840)2.39951266
30Focal motor seizures (HP:0011153)2.38025512
31Visual hallucinations (HP:0002367)2.37582354
32Decreased central vision (HP:0007663)2.35797141
33Amblyopia (HP:0000646)2.34789884
34Failure to thrive in infancy (HP:0001531)2.34404172
35Retinal dysplasia (HP:0007973)2.33954374
36Abnormal drinking behavior (HP:0030082)2.30214766
37Polydipsia (HP:0001959)2.30214766
38Ulnar bowing (HP:0003031)2.30193584
39Increased cerebral lipofuscin (HP:0011813)2.26848892
40Genetic anticipation (HP:0003743)2.22412382
41Rectal prolapse (HP:0002035)2.19689738
42Fetal akinesia sequence (HP:0001989)2.15958452
43Intellectual disability, severe (HP:0010864)2.11499829
44Abnormality of polysaccharide metabolism (HP:0011012)2.10432333
45Abnormality of glycosaminoglycan metabolism (HP:0004371)2.10432333
46Abnormality of mucopolysaccharide metabolism (HP:0011020)2.10432333
47Abnormality of the heme biosynthetic pathway (HP:0010472)2.08525098
48Hyperventilation (HP:0002883)2.06133225
49Turricephaly (HP:0000262)2.05424591
50Patellar aplasia (HP:0006443)2.05152989
51Absent speech (HP:0001344)2.05129816
52Rectovaginal fistula (HP:0000143)2.03128094
53Rectal fistula (HP:0100590)2.03128094
54Intestinal fistula (HP:0100819)2.02353676
55Gastrointestinal infarctions (HP:0005244)1.98012700
56Abnormal EKG (HP:0003115)1.93115441
57Lissencephaly (HP:0001339)1.93094720
58Abnormality of the parathyroid morphology (HP:0011766)1.92980565
59Polymicrogyria (HP:0002126)1.92770581
60Tetany (HP:0001281)1.92432184
61Severe muscular hypotonia (HP:0006829)1.91729226
62Concave nail (HP:0001598)1.91474622
63Abnormality of dental color (HP:0011073)1.91428950
64Aplasia/Hypoplasia of the patella (HP:0006498)1.91113246
65Vaginal fistula (HP:0004320)1.90384312
66Hypercortisolism (HP:0001578)1.90253810
67Lymphangioma (HP:0100764)1.89521862
68Prolonged QT interval (HP:0001657)1.88553654
69Mutism (HP:0002300)1.85964999
70Amelogenesis imperfecta (HP:0000705)1.85053968
71Peripheral hypomyelination (HP:0007182)1.83261084
72Pendular nystagmus (HP:0012043)1.82668290
73Ocular albinism (HP:0001107)1.82618705
74Unilateral renal agenesis (HP:0000122)1.81594732
75Nephronophthisis (HP:0000090)1.81479923
76Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.80982846
77Macular degeneration (HP:0000608)1.80950899
78Heart block (HP:0012722)1.77530439
79Intellectual disability, progressive (HP:0006887)1.77523412
80Rapidly progressive (HP:0003678)1.77520814
81Tented upper lip vermilion (HP:0010804)1.76743469
82Truncus arteriosus (HP:0001660)1.76548389
83Broad face (HP:0000283)1.76459470
84Atelectasis (HP:0100750)1.76088029
85Fatigable weakness (HP:0003473)1.73565754
86Abnormality of the neuromuscular junction (HP:0003398)1.73565754
87Epileptic encephalopathy (HP:0200134)1.73540405
88Stomatitis (HP:0010280)1.72961230
89Asymmetric septal hypertrophy (HP:0001670)1.72798315
90Polyphagia (HP:0002591)1.71412401
91Orchitis (HP:0100796)1.70483657
92Myositis (HP:0100614)1.69635472
93Stereotypic behavior (HP:0000733)1.69030344
94Abnormality of the costochondral junction (HP:0000919)1.68431485
95Widely patent fontanelles and sutures (HP:0004492)1.67690495
96Progressive cerebellar ataxia (HP:0002073)1.67266781
97Joint stiffness (HP:0001387)1.67020079
98Hypertensive crisis (HP:0100735)1.66686635
99Abnormal eating behavior (HP:0100738)1.66605152
100Spastic gait (HP:0002064)1.66176644

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK13.45842818
2PRKD33.30246993
3MAPK153.19491044
4SIK23.10907771
5MAP3K113.00704265
6ERN12.94993715
7TRIB32.84932593
8SIK32.35112942
9TNK22.33470261
10MARK12.18091953
11TAOK11.99901745
12MAP4K11.91823014
13WNK41.89438499
14PRKD21.88082929
15MUSK1.81858380
16MARK21.72636351
17DAPK21.68526413
18DYRK1B1.66008463
19GRK61.62368178
20SMG11.59212467
21TESK11.49901901
22IRAK41.25367216
23STK381.20840238
24DYRK21.19181263
25EPHB11.16807598
26ICK1.13540625
27MAP4K21.12360064
28MAPK131.11373051
29MAP2K31.10947598
30TYRO31.08794202
31PRPF4B1.05785889
32PDPK11.05404761
33RPS6KA21.05351474
34PHKG21.03590842
35PHKG11.03590842
36PAK61.01691834
37RIPK41.01347295
38MAP2K41.00664707
39STK110.96176068
40CAMKK10.96080080
41MAP2K60.94769472
42BCKDK0.94641956
43HIPK20.94546901
44TESK20.91289909
45BLK0.90910119
46IRAK30.90851769
47NTRK20.87418583
48MAP3K70.86759358
49TAOK20.86446625
50RPS6KA60.83500724
51MAP2K20.80990511
52RPS6KL10.80793731
53RPS6KC10.80793731
54LMTK20.80415633
55NTRK30.78985704
56TRIM280.75655556
57CAMK10.73859441
58IRAK20.73367447
59MAP3K10.73051186
60ADRBK20.72247359
61PRKCH0.71711784
62PTK60.71638180
63PRKCZ0.71243118
64PDK10.69678915
65TBK10.69025142
66PRKG20.68014103
67IKBKB0.66925589
68UHMK10.62707736
69CSNK1G30.61577044
70PTK2B0.58841584
71CHUK0.58524818
72PRKD10.57288314
73EPHA40.57251230
74PRKAA10.56372353
75CAMK40.56179947
76MAPKAPK30.55708303
77FES0.54210044
78PKN10.53076776
79INSRR0.52372076
80ADRBK10.52242747
81CSNK1G20.52181705
82MAPK80.50772110
83MAPK120.50730560
84BMX0.49765245
85MTOR0.46851823
86MAP3K30.45073447
87CDK50.44349878
88RPS6KA10.42920473
89PINK10.41968998
90MAP3K90.41713624
91PIK3CG0.41262398
92OXSR10.40667565
93CSK0.40286108
94HCK0.40285155
95ZAP700.39861135
96PKN20.39738690
97MINK10.39666548
98VRK20.39107126
99DAPK10.35677415
100DDR20.32376794

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.04519020
2Sulfur relay system_Homo sapiens_hsa041222.76601888
3Synaptic vesicle cycle_Homo sapiens_hsa047212.20619776
4Notch signaling pathway_Homo sapiens_hsa043302.08075828
5Nicotine addiction_Homo sapiens_hsa050332.05569093
6Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.05459230
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.85442406
8Phototransduction_Homo sapiens_hsa047441.78297480
9Cocaine addiction_Homo sapiens_hsa050301.77694069
10Glycosaminoglycan degradation_Homo sapiens_hsa005311.77516468
11Morphine addiction_Homo sapiens_hsa050321.53559896
12mTOR signaling pathway_Homo sapiens_hsa041501.53165449
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51901812
14VEGF signaling pathway_Homo sapiens_hsa043701.46120176
15Circadian entrainment_Homo sapiens_hsa047131.38888683
16Cholinergic synapse_Homo sapiens_hsa047251.36035349
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.36018768
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.35255873
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.33953736
20Insulin secretion_Homo sapiens_hsa049111.30123256
21Longevity regulating pathway - mammal_Homo sapiens_hsa042111.29356065
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29072028
23Fructose and mannose metabolism_Homo sapiens_hsa000511.22923815
24Axon guidance_Homo sapiens_hsa043601.21551450
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.20248976
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.20154249
27Collecting duct acid secretion_Homo sapiens_hsa049661.18566846
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18166752
29Glycerophospholipid metabolism_Homo sapiens_hsa005641.17335616
30Acute myeloid leukemia_Homo sapiens_hsa052211.17077882
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.14970041
32Other glycan degradation_Homo sapiens_hsa005111.13095641
33Endocytosis_Homo sapiens_hsa041441.13065284
34Hedgehog signaling pathway_Homo sapiens_hsa043401.12514120
35Carbohydrate digestion and absorption_Homo sapiens_hsa049731.12105176
36Glutamatergic synapse_Homo sapiens_hsa047241.10914420
37Inositol phosphate metabolism_Homo sapiens_hsa005621.10416810
38Dopaminergic synapse_Homo sapiens_hsa047281.09166684
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.07620078
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.07212185
41GABAergic synapse_Homo sapiens_hsa047271.06935285
42Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.05974290
43Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.05342180
44Amphetamine addiction_Homo sapiens_hsa050311.04111484
45Neurotrophin signaling pathway_Homo sapiens_hsa047221.01099631
46Lysosome_Homo sapiens_hsa041420.99938901
47Taste transduction_Homo sapiens_hsa047420.99764065
48AMPK signaling pathway_Homo sapiens_hsa041520.99077551
49Regulation of autophagy_Homo sapiens_hsa041400.98834865
50Estrogen signaling pathway_Homo sapiens_hsa049150.94642099
51Type II diabetes mellitus_Homo sapiens_hsa049300.93134294
52Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92726967
53Adipocytokine signaling pathway_Homo sapiens_hsa049200.91406890
54Calcium signaling pathway_Homo sapiens_hsa040200.91120991
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.90861270
56cAMP signaling pathway_Homo sapiens_hsa040240.86513792
57Insulin resistance_Homo sapiens_hsa049310.84724810
58MAPK signaling pathway_Homo sapiens_hsa040100.83939041
59Melanogenesis_Homo sapiens_hsa049160.82648951
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82611953
61Gastric acid secretion_Homo sapiens_hsa049710.82441645
62Oxytocin signaling pathway_Homo sapiens_hsa049210.81055729
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80875212
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.80837024
65Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.80818404
66Osteoclast differentiation_Homo sapiens_hsa043800.80650602
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.80024686
68GnRH signaling pathway_Homo sapiens_hsa049120.79684729
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.79683218
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79227498
71Chemokine signaling pathway_Homo sapiens_hsa040620.77759240
72Olfactory transduction_Homo sapiens_hsa047400.76571243
73Dorso-ventral axis formation_Homo sapiens_hsa043200.74949865
74ErbB signaling pathway_Homo sapiens_hsa040120.74381279
75Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74286858
76B cell receptor signaling pathway_Homo sapiens_hsa046620.71427339
77Circadian rhythm_Homo sapiens_hsa047100.70095608
78Insulin signaling pathway_Homo sapiens_hsa049100.69890490
79Choline metabolism in cancer_Homo sapiens_hsa052310.68045904
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66256217
81Tuberculosis_Homo sapiens_hsa051520.65863811
82Prolactin signaling pathway_Homo sapiens_hsa049170.65400978
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65268098
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64723534
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62827258
86Long-term potentiation_Homo sapiens_hsa047200.61982267
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60609508
88Ovarian steroidogenesis_Homo sapiens_hsa049130.58978264
89ABC transporters_Homo sapiens_hsa020100.58337994
90Salivary secretion_Homo sapiens_hsa049700.56961804
91TNF signaling pathway_Homo sapiens_hsa046680.51511041
92Non-small cell lung cancer_Homo sapiens_hsa052230.51509077
93Long-term depression_Homo sapiens_hsa047300.50902626
94Sphingolipid metabolism_Homo sapiens_hsa006000.49394441
95Hepatitis C_Homo sapiens_hsa051600.48799375
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45818492
97Bladder cancer_Homo sapiens_hsa052190.45435316
98Basal cell carcinoma_Homo sapiens_hsa052170.45221813
99T cell receptor signaling pathway_Homo sapiens_hsa046600.44149426
100Vibrio cholerae infection_Homo sapiens_hsa051100.42550983

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