ZNF200

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.77193373
2piRNA metabolic process (GO:0034587)4.61529396
3tryptophan catabolic process (GO:0006569)4.52791178
4indole-containing compound catabolic process (GO:0042436)4.52791178
5indolalkylamine catabolic process (GO:0046218)4.52791178
6fucose catabolic process (GO:0019317)4.42180560
7L-fucose metabolic process (GO:0042354)4.42180560
8L-fucose catabolic process (GO:0042355)4.42180560
9NAD biosynthetic process (GO:0009435)4.36419665
10kynurenine metabolic process (GO:0070189)4.30021379
11indolalkylamine metabolic process (GO:0006586)4.15159130
12DNA deamination (GO:0045006)3.91161708
13tryptophan metabolic process (GO:0006568)3.83449237
14DNA methylation involved in gamete generation (GO:0043046)3.80235615
15regulation of meiosis I (GO:0060631)3.78859623
16multicellular organism reproduction (GO:0032504)3.65324870
17pyridine nucleotide biosynthetic process (GO:0019363)3.44058863
18nicotinamide nucleotide biosynthetic process (GO:0019359)3.44058863
19detection of light stimulus involved in sensory perception (GO:0050962)3.42553626
20detection of light stimulus involved in visual perception (GO:0050908)3.42553626
21male meiosis I (GO:0007141)3.32266077
22protein K6-linked ubiquitination (GO:0085020)3.27799514
23cell wall macromolecule metabolic process (GO:0044036)3.25762077
24cellular biogenic amine catabolic process (GO:0042402)3.23575468
25amine catabolic process (GO:0009310)3.23575468
26retinal cone cell development (GO:0046549)3.12902149
27neural tube formation (GO:0001841)3.08930599
28cilium or flagellum-dependent cell motility (GO:0001539)3.07721454
29negative regulation of mast cell activation (GO:0033004)3.04193264
30protein K11-linked deubiquitination (GO:0035871)3.02219387
31response to pheromone (GO:0019236)3.01379659
32male meiosis (GO:0007140)2.99926673
33protein polyglutamylation (GO:0018095)2.99439137
34detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.95903711
35rRNA catabolic process (GO:0016075)2.95672386
36reciprocal DNA recombination (GO:0035825)2.89917997
37reciprocal meiotic recombination (GO:0007131)2.89917997
38RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.88762200
39meiotic chromosome segregation (GO:0045132)2.87650196
40regulation of female gonad development (GO:2000194)2.86123008
41sulfation (GO:0051923)2.85738604
42cellular response to ATP (GO:0071318)2.83166065
43indole-containing compound metabolic process (GO:0042430)2.80798844
44pseudouridine synthesis (GO:0001522)2.77982767
45interkinetic nuclear migration (GO:0022027)2.76402553
46DNA double-strand break processing (GO:0000729)2.75462799
47snRNA transcription (GO:0009301)2.71617905
48recombinational repair (GO:0000725)2.68998906
49double-strand break repair via homologous recombination (GO:0000724)2.68324560
50regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.67278232
51regulation of mitotic spindle checkpoint (GO:1903504)2.67278232
52benzene-containing compound metabolic process (GO:0042537)2.65604853
53behavioral response to ethanol (GO:0048149)2.63625236
54synapsis (GO:0007129)2.61282785
55cellular ketone body metabolic process (GO:0046950)2.59280298
56platelet dense granule organization (GO:0060155)2.56161159
57negative regulation of interleukin-1 beta production (GO:0032691)2.54068772
58positive regulation of meiosis (GO:0045836)2.53636545
59positive regulation of defense response to virus by host (GO:0002230)2.53388043
60DNA demethylation (GO:0080111)2.52085719
61somatic hypermutation of immunoglobulin genes (GO:0016446)2.50453467
62somatic diversification of immune receptors via somatic mutation (GO:0002566)2.50453467
63regulation of rhodopsin mediated signaling pathway (GO:0022400)2.48733141
64signal peptide processing (GO:0006465)2.48111649
65gene silencing by RNA (GO:0031047)2.47912257
66negative regulation of transcription regulatory region DNA binding (GO:2000678)2.47472193
67meiosis I (GO:0007127)2.46658546
68regulation of nuclear cell cycle DNA replication (GO:0033262)2.45381596
69meiotic cell cycle (GO:0051321)2.44991677
70rhodopsin mediated signaling pathway (GO:0016056)2.44550338
71negative regulation of telomere maintenance (GO:0032205)2.43700246
72negative regulation of interleukin-1 production (GO:0032692)2.43375300
73sperm motility (GO:0030317)2.42354068
74tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.40049274
75RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.40049274
76negative regulation of systemic arterial blood pressure (GO:0003085)2.39043400
77positive regulation of meiotic cell cycle (GO:0051446)2.39006299
78cellular response to exogenous dsRNA (GO:0071360)2.38890886
79regulation of glucokinase activity (GO:0033131)2.36434365
80regulation of hexokinase activity (GO:1903299)2.36434365
81single strand break repair (GO:0000012)2.36084238
82positive regulation of oligodendrocyte differentiation (GO:0048714)2.35923350
83gonadal mesoderm development (GO:0007506)2.34996688
84protein K48-linked deubiquitination (GO:0071108)2.33854681
85regulation of defense response to virus by host (GO:0050691)2.33057119
86axoneme assembly (GO:0035082)2.32312649
87cAMP catabolic process (GO:0006198)2.32205047
88epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.30664882
89N-acetylglucosamine metabolic process (GO:0006044)2.30623103
90negative regulation of cAMP-mediated signaling (GO:0043951)2.29652328
91mitochondrial respiratory chain complex I assembly (GO:0032981)2.28650297
92NADH dehydrogenase complex assembly (GO:0010257)2.28650297
93mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.28650297
94ketone body metabolic process (GO:1902224)2.28594536
95photoreceptor cell development (GO:0042461)2.28453448
96negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.28063787
97negative regulation of translation, ncRNA-mediated (GO:0040033)2.28063787
98regulation of translation, ncRNA-mediated (GO:0045974)2.28063787
99regulation of acrosome reaction (GO:0060046)2.27205497
100adaptation of signaling pathway (GO:0023058)2.26839168

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ZNF274_21170338_ChIP-Seq_K562_Hela3.95592345
2VDR_22108803_ChIP-Seq_LS180_Human2.85277943
3IGF1R_20145208_ChIP-Seq_DFB_Human2.75211176
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.75064074
5* NOTCH1_21737748_ChIP-Seq_TLL_Human2.64904771
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.61014975
7GBX2_23144817_ChIP-Seq_PC3_Human2.54703602
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.20811909
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.19414262
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.14274529
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10278355
12EWS_26573619_Chip-Seq_HEK293_Human2.09270043
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.07499747
14EZH2_22144423_ChIP-Seq_EOC_Human2.07391662
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.00309270
16ER_23166858_ChIP-Seq_MCF-7_Human1.98385153
17SALL1_21062744_ChIP-ChIP_HESCs_Human1.98053432
18CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96632920
19P300_19829295_ChIP-Seq_ESCs_Human1.89431589
20TAF15_26573619_Chip-Seq_HEK293_Human1.88678418
21FUS_26573619_Chip-Seq_HEK293_Human1.86766983
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.84756734
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.81998499
24RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79697652
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.78543587
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.75033672
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73639255
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.73392208
29UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.71350063
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69122021
31STAT3_23295773_ChIP-Seq_U87_Human1.66571558
32IRF1_19129219_ChIP-ChIP_H3396_Human1.64371443
33IRF8_21731497_ChIP-ChIP_J774_Mouse1.58293493
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57971640
35TP53_22573176_ChIP-Seq_HFKS_Human1.56830672
36GABP_17652178_ChIP-ChIP_JURKAT_Human1.51508220
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50144726
38BCAT_22108803_ChIP-Seq_LS180_Human1.49771698
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48014604
40CBP_20019798_ChIP-Seq_JUKART_Human1.48014604
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.47465063
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45620848
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45620848
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38115017
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37270746
46PRDM14_20953172_ChIP-Seq_ESCs_Human1.36908526
47GATA3_26560356_Chip-Seq_TH2_Human1.35902703
48NANOG_19829295_ChIP-Seq_ESCs_Human1.35735930
49SOX2_19829295_ChIP-Seq_ESCs_Human1.35735930
50STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.35596258
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35492588
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.33885707
53EST1_17652178_ChIP-ChIP_JURKAT_Human1.33332170
54TCF4_23295773_ChIP-Seq_U87_Human1.32070783
55AR_25329375_ChIP-Seq_VCAP_Human1.31968019
56GATA3_21878914_ChIP-Seq_MCF-7_Human1.31835430
57IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.31580837
58MYC_18940864_ChIP-ChIP_HL60_Human1.31468097
59NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28736705
60FOXA1_25329375_ChIP-Seq_VCAP_Human1.28489330
61FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28489330
62SMAD4_21799915_ChIP-Seq_A2780_Human1.25964448
63KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25684311
64FOXA1_21572438_ChIP-Seq_LNCaP_Human1.25297248
65SMAD4_21741376_ChIP-Seq_EPCs_Human1.24346831
66RUNX2_22187159_ChIP-Seq_PCA_Human1.22694500
67VDR_23849224_ChIP-Seq_CD4+_Human1.21071471
68* AR_20517297_ChIP-Seq_VCAP_Human1.20120969
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.19890026
70TCF4_22108803_ChIP-Seq_LS180_Human1.17194622
71EGR1_23403033_ChIP-Seq_LIVER_Mouse1.14898299
72NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14865423
73PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14510365
74GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14022474
75NCOR_22424771_ChIP-Seq_293T_Human1.13882541
76AUTS2_25519132_ChIP-Seq_293T-REX_Human1.12616864
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.12415816
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.12066690
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11587994
80BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10589701
81EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08692880
82HOXB7_26014856_ChIP-Seq_BT474_Human1.08611891
83FLI1_21867929_ChIP-Seq_TH2_Mouse1.08412301
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08327038
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07742003
86VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.06452967
87CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06130905
88SMRT_27268052_Chip-Seq_Bcells_Human1.05017123
89PIAS1_25552417_ChIP-Seq_VCAP_Human1.04796670
90AR_21572438_ChIP-Seq_LNCaP_Human1.03445243
91TP63_19390658_ChIP-ChIP_HaCaT_Human1.02972091
92CRX_20693478_ChIP-Seq_RETINA_Mouse1.01548448
93PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98455240
94CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98209723
95GATA3_26560356_Chip-Seq_TH1_Human0.97956826
96NANOG_20526341_ChIP-Seq_ESCs_Human0.97781364
97ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96986874
98TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96071208
99CDX2_22108803_ChIP-Seq_LS180_Human0.95741444
100ELK1_19687146_ChIP-ChIP_HELA_Human0.95550828

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.73383009
2MP0008877_abnormal_DNA_methylation3.31643000
3MP0003646_muscle_fatigue3.28103845
4MP0003195_calcinosis3.16324260
5MP0002102_abnormal_ear_morphology2.44192614
6MP0003718_maternal_effect2.25440445
7MP0003724_increased_susceptibility_to2.20272386
8MP0005551_abnormal_eye_electrophysiolog2.16887820
9MP0005174_abnormal_tail_pigmentation2.16757950
10MP0001485_abnormal_pinna_reflex2.08550473
11MP0009046_muscle_twitch1.97558360
12MP0005410_abnormal_fertilization1.85351133
13MP0002277_abnormal_respiratory_mucosa1.76972689
14MP0000372_irregular_coat_pigmentation1.74397775
15MP0002138_abnormal_hepatobiliary_system1.73797643
16MP0001968_abnormal_touch/_nociception1.69991491
17MP0005253_abnormal_eye_physiology1.67815039
18MP0006292_abnormal_olfactory_placode1.65278250
19MP0000427_abnormal_hair_cycle1.64269861
20MP0002837_dystrophic_cardiac_calcinosis1.62025274
21MP0003136_yellow_coat_color1.56445645
22MP0008872_abnormal_physiological_respon1.55337330
23MP0001501_abnormal_sleep_pattern1.53413679
24MP0008875_abnormal_xenobiotic_pharmacok1.52128668
25MP0008057_abnormal_DNA_replication1.51859545
26MP0006072_abnormal_retinal_apoptosis1.51711825
27MP0005671_abnormal_response_to1.50587884
28MP0008058_abnormal_DNA_repair1.49241261
29MP0001986_abnormal_taste_sensitivity1.47039119
30MP0001929_abnormal_gametogenesis1.46876592
31MP0000015_abnormal_ear_pigmentation1.45088510
32MP0002735_abnormal_chemical_nociception1.42050143
33MP0005377_hearing/vestibular/ear_phenot1.39496990
34MP0003878_abnormal_ear_physiology1.39496990
35MP0000685_abnormal_immune_system1.39488382
36MP0008995_early_reproductive_senescence1.38279967
37MP0001800_abnormal_humoral_immune1.37745265
38MP0002736_abnormal_nociception_after1.33945910
39MP0005075_abnormal_melanosome_morpholog1.33699770
40MP0000383_abnormal_hair_follicle1.32045123
41MP0004742_abnormal_vestibular_system1.29243989
42MP0009764_decreased_sensitivity_to1.25007908
43MP0003693_abnormal_embryo_hatching1.23411001
44MP0003698_abnormal_male_reproductive1.22006007
45MP0003950_abnormal_plasma_membrane1.20692649
46MP0002148_abnormal_hypersensitivity_rea1.18938800
47MP0009785_altered_susceptibility_to1.18540635
48MP0004142_abnormal_muscle_tone1.17996929
49MP0002095_abnormal_skin_pigmentation1.17706705
50MP0002210_abnormal_sex_determination1.16614348
51MP0005646_abnormal_pituitary_gland1.15171541
52MP0005645_abnormal_hypothalamus_physiol1.14231921
53MP0001919_abnormal_reproductive_system1.14081298
54MP0005389_reproductive_system_phenotype1.13176755
55MP0009745_abnormal_behavioral_response1.12437892
56MP0000631_abnormal_neuroendocrine_gland1.11287850
57MP0002723_abnormal_immune_serum1.08570274
58MP0005167_abnormal_blood-brain_barrier1.06811215
59MP0006082_CNS_inflammation1.04499047
60MP0004043_abnormal_pH_regulation1.02725476
61MP0001873_stomach_inflammation1.00211242
62MP0005387_immune_system_phenotype1.00047794
63MP0001790_abnormal_immune_system1.00047794
64MP0000653_abnormal_sex_gland0.98839111
65MP0006276_abnormal_autonomic_nervous0.98349896
66MP0002452_abnormal_antigen_presenting0.97389182
67MP0005083_abnormal_biliary_tract0.96498820
68MP0005310_abnormal_salivary_gland0.96130894
69MP0002234_abnormal_pharynx_morphology0.95710972
70MP0001486_abnormal_startle_reflex0.93905474
71MP0000470_abnormal_stomach_morphology0.92939848
72MP0005395_other_phenotype0.92384561
73MP0010094_abnormal_chromosome_stability0.92052513
74MP0001145_abnormal_male_reproductive0.91523711
75MP0002928_abnormal_bile_duct0.89514766
76MP0002160_abnormal_reproductive_system0.88521628
77MP0002272_abnormal_nervous_system0.88147959
78MP0004147_increased_porphyrin_level0.88132048
79MP0000371_diluted_coat_color0.87728037
80MP0005266_abnormal_metabolism0.87086511
81MP0002693_abnormal_pancreas_physiology0.87051819
82MP0002420_abnormal_adaptive_immunity0.86536362
83MP0001819_abnormal_immune_cell0.86228620
84MP0004381_abnormal_hair_follicle0.86183827
85MP0004885_abnormal_endolymph0.85379755
86MP0005000_abnormal_immune_tolerance0.83313452
87MP0001835_abnormal_antigen_presentation0.83265476
88MP0002638_abnormal_pupillary_reflex0.80213048
89MP0001119_abnormal_female_reproductive0.78290988
90MP0001293_anophthalmia0.77662192
91MP0002733_abnormal_thermal_nociception0.76539914
92MP0002067_abnormal_sensory_capabilities0.75743800
93MP0001324_abnormal_eye_pigmentation0.75523289
94MP0003567_abnormal_fetal_cardiomyocyte0.74118385
95MP0005195_abnormal_posterior_eye0.73990194
96MP0002254_reproductive_system_inflammat0.73838710
97MP0008961_abnormal_basal_metabolism0.73274890
98MP0002405_respiratory_system_inflammati0.72181993
99MP0001970_abnormal_pain_threshold0.71792104
100MP0003890_abnormal_embryonic-extraembry0.71751745

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.64687669
2Attenuation of retinal blood vessels (HP:0007843)4.44018311
3Pancreatic fibrosis (HP:0100732)4.14808479
4Abnormality of midbrain morphology (HP:0002418)4.06954732
5Molar tooth sign on MRI (HP:0002419)4.06954732
6Congenital stationary night blindness (HP:0007642)3.99483149
7True hermaphroditism (HP:0010459)3.90762975
8Nephronophthisis (HP:0000090)3.37596027
9Genetic anticipation (HP:0003743)3.20479598
10Abnormality of the renal cortex (HP:0011035)3.10425850
11Birth length less than 3rd percentile (HP:0003561)2.99312267
12Abnormality of the renal medulla (HP:0100957)2.91677226
13Cystic liver disease (HP:0006706)2.89557588
14Progressive cerebellar ataxia (HP:0002073)2.80141474
15Pendular nystagmus (HP:0012043)2.70758742
16Absent rod-and cone-mediated responses on ERG (HP:0007688)2.69621204
17Chronic hepatic failure (HP:0100626)2.69243078
18Stomatitis (HP:0010280)2.69059218
19Abnormal biliary tract physiology (HP:0012439)2.57249325
20Bile duct proliferation (HP:0001408)2.57249325
21Chromosomal breakage induced by crosslinking agents (HP:0003221)2.54413897
22Concave nail (HP:0001598)2.52677022
23Abnormality of alanine metabolism (HP:0010916)2.52589545
24Hyperalaninemia (HP:0003348)2.52589545
25Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.52589545
26Abolished electroretinogram (ERG) (HP:0000550)2.52227332
27Renal cortical cysts (HP:0000803)2.49068664
28Type II lissencephaly (HP:0007260)2.48639172
29Aplasia/Hypoplasia of the tibia (HP:0005772)2.48434368
30Aplasia/Hypoplasia of the tongue (HP:0010295)2.47001289
31Progressive inability to walk (HP:0002505)2.46386344
32Furrowed tongue (HP:0000221)2.43226950
33Chromsome breakage (HP:0040012)2.41029524
34Abnormal rod and cone electroretinograms (HP:0008323)2.39993238
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.39146910
36Inability to walk (HP:0002540)2.38336106
37Congenital sensorineural hearing impairment (HP:0008527)2.37478094
38Fair hair (HP:0002286)2.37346570
39Anencephaly (HP:0002323)2.34233326
40Gaze-evoked nystagmus (HP:0000640)2.32369904
41Absent/shortened dynein arms (HP:0200106)2.29012979
42Dynein arm defect of respiratory motile cilia (HP:0012255)2.29012979
43Increased neuronal autofluorescent lipopigment (HP:0002074)2.27957746
44Patellar aplasia (HP:0006443)2.26933937
45Abnormality of the renal collecting system (HP:0004742)2.23672530
463-Methylglutaconic aciduria (HP:0003535)2.23213339
47Generalized hypopigmentation of hair (HP:0011358)2.23002747
48Hyperventilation (HP:0002883)2.22999686
49Decreased central vision (HP:0007663)2.21162000
50Aplasia/Hypoplasia of the patella (HP:0006498)2.16820197
51Oligodactyly (hands) (HP:0001180)2.16743179
52Cerebellar dysplasia (HP:0007033)2.15648879
53Ectopic kidney (HP:0000086)2.13295729
54Abnormality of chromosome stability (HP:0003220)2.11660587
55Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.11442026
56Abnormal delayed hypersensitivity skin test (HP:0002963)2.10845308
57Congenital hepatic fibrosis (HP:0002612)2.10683936
58Tubular atrophy (HP:0000092)2.10081794
59Duplicated collecting system (HP:0000081)2.09615733
60Clubbing of toes (HP:0100760)2.08563052
61Clumsiness (HP:0002312)2.06693077
62Medial flaring of the eyebrow (HP:0010747)2.05561816
63Sclerocornea (HP:0000647)2.04194793
64Polydipsia (HP:0001959)2.02993460
65Abnormal drinking behavior (HP:0030082)2.02993460
66Increased corneal curvature (HP:0100692)2.02654244
67Keratoconus (HP:0000563)2.02654244
68Partial agenesis of the corpus callosum (HP:0001338)2.00976092
69Abnormality of DNA repair (HP:0003254)2.00204294
70Aplasia/Hypoplasia of the fovea (HP:0008060)1.99967207
71Hypoplasia of the fovea (HP:0007750)1.99967207
72Stomach cancer (HP:0012126)1.99606457
73Bony spicule pigmentary retinopathy (HP:0007737)1.99525947
74Abnormality of the pons (HP:0007361)1.98566874
75Supernumerary spleens (HP:0009799)1.98373910
76Constricted visual fields (HP:0001133)1.93620671
77Hypoplasia of the pons (HP:0012110)1.93501900
78Severe muscular hypotonia (HP:0006829)1.93155232
79Aplasia/Hypoplasia of the spleen (HP:0010451)1.92435009
80Febrile seizures (HP:0002373)1.92234605
81Meckel diverticulum (HP:0002245)1.91239547
82Decreased electroretinogram (ERG) amplitude (HP:0000654)1.90784037
83Retrobulbar optic neuritis (HP:0100654)1.90307583
84Optic neuritis (HP:0100653)1.90307583
85Abnormality of the ileum (HP:0001549)1.89755882
86Male pseudohermaphroditism (HP:0000037)1.89362633
87Protruding tongue (HP:0010808)1.88900771
88Postaxial foot polydactyly (HP:0001830)1.87991998
89Sloping forehead (HP:0000340)1.86688610
90Short tibia (HP:0005736)1.81238778
91Photophobia (HP:0000613)1.75832855
92Decreased circulating renin level (HP:0003351)1.75028117
93Recurrent cutaneous fungal infections (HP:0011370)1.74118547
94Chronic mucocutaneous candidiasis (HP:0002728)1.74118547
95Congenital, generalized hypertrichosis (HP:0004540)1.73955670
96Preaxial hand polydactyly (HP:0001177)1.73953669
97Optic disc pallor (HP:0000543)1.70758592
98Severe visual impairment (HP:0001141)1.69753644
99Abnormality of the preputium (HP:0100587)1.69560332
100Oligohydramnios (HP:0001562)1.69496722

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.90002915
2INSRR5.59576558
3ADRBK23.71437434
4ACVR1B3.62536629
5ZAK3.00710928
6BMPR1B2.96350138
7GRK12.83028954
8TAOK32.64449692
9PINK12.60894579
10NUAK12.27495446
11MAP4K22.09123997
12WNK31.92940470
13TLK11.89478743
14TXK1.49394195
15MAP3K41.38114521
16OXSR11.30959609
17BRSK21.30834664
18TRIM281.25013561
19MAPK131.22012742
20ADRBK11.21672592
21WNK41.19105939
22IKBKB1.14340613
23EIF2AK31.03678747
24PTK2B1.02400944
25PLK40.94784739
26DAPK20.94456180
27STK38L0.93480821
28IKBKE0.93089851
29STK390.91206104
30CHUK0.88739954
31PIM10.87798754
32NTRK30.87438115
33STK30.84454319
34IRAK40.81301474
35MARK30.79605712
36IRAK10.74477478
37SYK0.74400855
38MAP4K10.73263371
39TEC0.72015692
40TGFBR10.71889265
41PRKCQ0.70227617
42PAK30.68677103
43DYRK30.68378194
44LATS10.66357923
45CAMKK20.66002731
46MKNK20.65453729
47PIK3CG0.64635188
48GRK70.64254859
49TNK20.63166833
50CHEK20.62551811
51RPS6KA50.59998052
52KIT0.56691132
53TNIK0.56428387
54ITK0.56078059
55WEE10.55570507
56MAP2K10.55336774
57SIK20.55066913
58LYN0.54908074
59GRK60.54374001
60JAK30.53123646
61PRKAA20.52590716
62AKT30.52067663
63DYRK20.51028955
64NEK20.50800209
65PLK10.49224497
66PRKCE0.48825429
67VRK10.48525928
68RAF10.46966073
69MAP3K140.45851401
70PRKCG0.45381795
71LCK0.44456765
72MAP3K20.44268572
73PLK20.43838851
74KSR10.42728563
75MATK0.41691874
76ATR0.40204303
77CSNK1D0.38892986
78BLK0.38590762
79NLK0.38045490
80MELK0.37748092
81MAP2K70.37649343
82TBK10.36129194
83PKN10.35036030
84CSNK1G10.34757662
85BUB10.33092582
86BTK0.32982516
87MAPKAPK50.32969851
88CSNK1A1L0.32386225
89HCK0.32360546
90CSNK1G20.31359993
91PRKCZ0.31287646
92BCKDK0.31236887
93MUSK0.30863040
94ATM0.29662600
95PRKCI0.29217416
96CASK0.28263784
97PRKACB0.27528033
98DYRK1A0.27011844
99ERBB30.26876865
100PRKACA0.26423581

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.92811044
2Phototransduction_Homo sapiens_hsa047443.00493333
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.81348794
4Homologous recombination_Homo sapiens_hsa034402.64316383
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.34963176
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.29642687
7Fanconi anemia pathway_Homo sapiens_hsa034602.18855830
8Selenocompound metabolism_Homo sapiens_hsa004502.10967264
9Nitrogen metabolism_Homo sapiens_hsa009101.98222388
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.97741149
11Primary immunodeficiency_Homo sapiens_hsa053401.93736159
12Butanoate metabolism_Homo sapiens_hsa006501.87886621
13Linoleic acid metabolism_Homo sapiens_hsa005911.86070755
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.82845731
15RNA polymerase_Homo sapiens_hsa030201.75621351
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.74181874
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.67209767
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.63487068
19Basal transcription factors_Homo sapiens_hsa030221.60684002
20Tryptophan metabolism_Homo sapiens_hsa003801.57574281
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54365595
22Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.51535852
23Ether lipid metabolism_Homo sapiens_hsa005651.46155316
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.45159397
25Caffeine metabolism_Homo sapiens_hsa002321.44423248
26ABC transporters_Homo sapiens_hsa020101.42807068
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42047709
28Taste transduction_Homo sapiens_hsa047421.41051282
29Nicotine addiction_Homo sapiens_hsa050331.41000204
30Olfactory transduction_Homo sapiens_hsa047401.40623599
31Graft-versus-host disease_Homo sapiens_hsa053321.32813671
32Dorso-ventral axis formation_Homo sapiens_hsa043201.30987673
33Regulation of autophagy_Homo sapiens_hsa041401.30062087
34RNA degradation_Homo sapiens_hsa030181.27657058
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.26065214
36One carbon pool by folate_Homo sapiens_hsa006701.14228040
37Morphine addiction_Homo sapiens_hsa050321.11186534
38Allograft rejection_Homo sapiens_hsa053301.07395947
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02521568
40Type I diabetes mellitus_Homo sapiens_hsa049400.97179040
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96429530
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95663664
43Non-homologous end-joining_Homo sapiens_hsa034500.92847012
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.92669912
45NF-kappa B signaling pathway_Homo sapiens_hsa040640.91250330
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.89791619
47Ovarian steroidogenesis_Homo sapiens_hsa049130.89734530
48Autoimmune thyroid disease_Homo sapiens_hsa053200.89118906
49Chemical carcinogenesis_Homo sapiens_hsa052040.87568850
50Serotonergic synapse_Homo sapiens_hsa047260.85453510
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.85125097
52Asthma_Homo sapiens_hsa053100.79159142
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78567712
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.77048565
55Oxidative phosphorylation_Homo sapiens_hsa001900.76393376
56Peroxisome_Homo sapiens_hsa041460.75172170
57Protein export_Homo sapiens_hsa030600.74847650
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.73126005
59Glycerolipid metabolism_Homo sapiens_hsa005610.71092566
60Purine metabolism_Homo sapiens_hsa002300.69784762
61Arachidonic acid metabolism_Homo sapiens_hsa005900.67262559
62Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64671153
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62405648
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.62398242
65Fatty acid biosynthesis_Homo sapiens_hsa000610.61212377
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60667797
67Pyrimidine metabolism_Homo sapiens_hsa002400.59939877
68Hematopoietic cell lineage_Homo sapiens_hsa046400.59716944
69Parkinsons disease_Homo sapiens_hsa050120.56405522
70Base excision repair_Homo sapiens_hsa034100.55105775
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53418930
72GABAergic synapse_Homo sapiens_hsa047270.53356838
73Mismatch repair_Homo sapiens_hsa034300.52897936
74Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52739802
75RNA transport_Homo sapiens_hsa030130.52462648
76Systemic lupus erythematosus_Homo sapiens_hsa053220.51230627
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49786493
78Herpes simplex infection_Homo sapiens_hsa051680.48762040
79Histidine metabolism_Homo sapiens_hsa003400.46733984
80Antigen processing and presentation_Homo sapiens_hsa046120.46492160
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45622034
82Circadian entrainment_Homo sapiens_hsa047130.45025158
83Retinol metabolism_Homo sapiens_hsa008300.44660608
84Rheumatoid arthritis_Homo sapiens_hsa053230.44260508
85Propanoate metabolism_Homo sapiens_hsa006400.42899248
86Cell cycle_Homo sapiens_hsa041100.42543009
87Calcium signaling pathway_Homo sapiens_hsa040200.41944699
88Huntingtons disease_Homo sapiens_hsa050160.39589739
89Legionellosis_Homo sapiens_hsa051340.39424609
90TNF signaling pathway_Homo sapiens_hsa046680.39268238
91Staphylococcus aureus infection_Homo sapiens_hsa051500.39249828
92African trypanosomiasis_Homo sapiens_hsa051430.38958329
93Type II diabetes mellitus_Homo sapiens_hsa049300.38954859
94Vitamin digestion and absorption_Homo sapiens_hsa049770.38199832
95Glutamatergic synapse_Homo sapiens_hsa047240.37811038
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.37311014
97Tuberculosis_Homo sapiens_hsa051520.36258982
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36231897
99T cell receptor signaling pathway_Homo sapiens_hsa046600.35969093
100Malaria_Homo sapiens_hsa051440.34992386

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