ZNF160

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a Kruppel-related zinc finger protein which is characterized by the presence of an N-terminal repressor domain, the Kruppel-associated box (KRAB). The KRAB domain is a potent repressor of transcription; thus this protein may function in transcription regulation. Multiple transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)4.91404484
2neural tube formation (GO:0001841)4.88985412
3pyrimidine nucleobase catabolic process (GO:0006208)4.76248211
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.04121772
5establishment of protein localization to Golgi (GO:0072600)3.85620583
6nucleobase catabolic process (GO:0046113)3.65707247
7nonmotile primary cilium assembly (GO:0035058)3.61864849
8regulation of cilium movement (GO:0003352)3.60965796
9behavioral response to nicotine (GO:0035095)3.60929515
10somite development (GO:0061053)3.54925030
11pyrimidine dimer repair (GO:0006290)3.49039946
12epithelial cilium movement (GO:0003351)3.47182744
13kidney morphogenesis (GO:0060993)3.44434728
14negative regulation of translation, ncRNA-mediated (GO:0040033)3.42869802
15regulation of translation, ncRNA-mediated (GO:0045974)3.42869802
16negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.42869802
17protein targeting to Golgi (GO:0000042)3.41550730
18limb bud formation (GO:0060174)3.30500869
19negative regulation of cytosolic calcium ion concentration (GO:0051481)3.29151517
20DNA integration (GO:0015074)3.28181703
21retrograde transport, vesicle recycling within Golgi (GO:0000301)3.27385957
22histone H3-K9 methylation (GO:0051567)3.24076814
23olfactory bulb development (GO:0021772)3.21793480
24mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.17410543
25positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.17410543
26cilium morphogenesis (GO:0060271)3.12945015
27protein K11-linked deubiquitination (GO:0035871)3.10378543
28regulation of development, heterochronic (GO:0040034)3.02776790
29glycosphingolipid biosynthetic process (GO:0006688)2.99947561
30protein polyglutamylation (GO:0018095)2.99468109
31cilium organization (GO:0044782)2.98957414
32positive regulation of mitochondrial fission (GO:0090141)2.97705599
33regulation of telomere maintenance (GO:0032204)2.95207552
34cilium assembly (GO:0042384)2.93314899
35embryonic epithelial tube formation (GO:0001838)2.90649561
36protein localization to Golgi apparatus (GO:0034067)2.90400188
37presynaptic membrane assembly (GO:0097105)2.89789116
38positive regulation of developmental pigmentation (GO:0048087)2.85081305
39regulation of timing of cell differentiation (GO:0048505)2.83730269
40interkinetic nuclear migration (GO:0022027)2.83377814
41protein localization to cilium (GO:0061512)2.80349410
42intraciliary transport (GO:0042073)2.79265201
43cilium movement (GO:0003341)2.77596279
44sulfation (GO:0051923)2.77060710
45epithelial tube formation (GO:0072175)2.75811802
46hindbrain development (GO:0030902)2.71889369
47forebrain neuron differentiation (GO:0021879)2.71554122
48RNA destabilization (GO:0050779)2.71513380
49calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.70268155
50limb development (GO:0060173)2.70247540
51appendage development (GO:0048736)2.70247540
52regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.68077137
53presynaptic membrane organization (GO:0097090)2.67501861
54regulation of pigment cell differentiation (GO:0050932)2.66775188
55fucose catabolic process (GO:0019317)2.66510949
56L-fucose metabolic process (GO:0042354)2.66510949
57L-fucose catabolic process (GO:0042355)2.66510949
58retinal cone cell development (GO:0046549)2.65492952
59gamma-aminobutyric acid transport (GO:0015812)2.63461347
60single strand break repair (GO:0000012)2.59959098
61cilium or flagellum-dependent cell motility (GO:0001539)2.59798031
62dorsal/ventral axis specification (GO:0009950)2.59064075
63genitalia morphogenesis (GO:0035112)2.58667598
64glial cell proliferation (GO:0014009)2.57355096
65axoneme assembly (GO:0035082)2.56622006
66histone H3-K9 modification (GO:0061647)2.56279408
67spinal cord development (GO:0021510)2.55940743
68detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.54540171
69regulation of acyl-CoA biosynthetic process (GO:0050812)2.52426943
70cellular component assembly involved in morphogenesis (GO:0010927)2.50311983
71cornea development in camera-type eye (GO:0061303)2.49253889
72phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.49119701
73indolalkylamine metabolic process (GO:0006586)2.48622193
74Golgi to endosome transport (GO:0006895)2.46655149
75histone mRNA catabolic process (GO:0071044)2.46527856
76left/right axis specification (GO:0070986)2.46426207
77postsynaptic membrane organization (GO:0001941)2.46011414
78somite rostral/caudal axis specification (GO:0032525)2.43001684
79photoreceptor cell maintenance (GO:0045494)2.42884870
80photoreceptor cell development (GO:0042461)2.42398688
81pancreas development (GO:0031016)2.41827135
82otic vesicle formation (GO:0030916)2.41661942
83regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.41434844
84head development (GO:0060322)2.41369224
85intra-Golgi vesicle-mediated transport (GO:0006891)2.41277806
86microtubule anchoring (GO:0034453)2.41015257
87positive regulation of oligodendrocyte differentiation (GO:0048714)2.40120923
88pericardium development (GO:0060039)2.39101568
89axonal fasciculation (GO:0007413)2.37930292
90behavioral response to ethanol (GO:0048149)2.37810935
91negative regulation of telomere maintenance (GO:0032205)2.37233198
92regulation of oligodendrocyte differentiation (GO:0048713)2.36470933
93cytoplasmic mRNA processing body assembly (GO:0033962)2.33152599
94primary amino compound metabolic process (GO:1901160)2.31805920
95inner ear receptor stereocilium organization (GO:0060122)2.31087272
96negative regulation of oligodendrocyte differentiation (GO:0048715)2.31079498
97synapse assembly (GO:0007416)2.30729963
98mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.29119801
99centriole replication (GO:0007099)2.28906507
100cerebral cortex radially oriented cell migration (GO:0021799)2.28283418

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.39581871
2GBX2_23144817_ChIP-Seq_PC3_Human3.11550985
3POU3F2_20337985_ChIP-ChIP_501MEL_Human2.89805871
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.74840129
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.72779856
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.72649743
7EZH2_22144423_ChIP-Seq_EOC_Human2.61485010
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.61047643
9VDR_22108803_ChIP-Seq_LS180_Human2.46149037
10TAF15_26573619_Chip-Seq_HEK293_Human2.37156650
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.32691804
12IGF1R_20145208_ChIP-Seq_DFB_Human2.23991018
13P300_19829295_ChIP-Seq_ESCs_Human2.23340151
14FUS_26573619_Chip-Seq_HEK293_Human2.20693717
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.11543867
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.09206694
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07297969
18PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.07019761
19SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.04335245
20AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.03661720
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.96677338
22PIAS1_25552417_ChIP-Seq_VCAP_Human1.95593980
23EWS_26573619_Chip-Seq_HEK293_Human1.94345119
24IRF1_19129219_ChIP-ChIP_H3396_Human1.92679071
25MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.92037273
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89046781
27SMAD4_21799915_ChIP-Seq_A2780_Human1.79055041
28STAT3_23295773_ChIP-Seq_U87_Human1.77486173
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72300184
30POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.71030378
31TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71030378
32ER_23166858_ChIP-Seq_MCF-7_Human1.70329580
33CBP_20019798_ChIP-Seq_JUKART_Human1.68412503
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.68412503
35UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.67888508
36BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.65169303
37SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63386087
38SMAD3_21741376_ChIP-Seq_EPCs_Human1.61881825
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60814885
40TCF4_23295773_ChIP-Seq_U87_Human1.59592158
41OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59020242
42TOP2B_26459242_ChIP-Seq_MCF-7_Human1.57263713
43AR_25329375_ChIP-Seq_VCAP_Human1.55945493
44RBPJ_22232070_ChIP-Seq_NCS_Mouse1.55771234
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.53674020
46NR3C1_21868756_ChIP-Seq_MCF10A_Human1.47373206
47RUNX2_22187159_ChIP-Seq_PCA_Human1.44703476
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40853413
49BCAT_22108803_ChIP-Seq_LS180_Human1.38915099
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.34714905
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32777376
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31143996
53* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.31012227
54TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.28989202
55NANOG_18555785_Chip-Seq_ESCs_Mouse1.27226571
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26966990
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.26150622
58TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25477307
59TP53_16413492_ChIP-PET_HCT116_Human1.24097526
60RNF2_27304074_Chip-Seq_NSC_Mouse1.21643173
61AHR_22903824_ChIP-Seq_MCF-7_Human1.18991301
62ARNT_22903824_ChIP-Seq_MCF-7_Human1.18856640
63TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18187334
64* TCF4_22108803_ChIP-Seq_LS180_Human1.17588412
65FLI1_21867929_ChIP-Seq_TH2_Mouse1.17509049
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.17089972
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.14866903
68NANOG_19829295_ChIP-Seq_ESCs_Human1.14086541
69SOX2_19829295_ChIP-Seq_ESCs_Human1.14086541
70CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13565157
71WT1_19549856_ChIP-ChIP_CCG9911_Human1.13541056
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13031644
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12535898
74TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11592167
75* TP63_19390658_ChIP-ChIP_HaCaT_Human1.11197786
76PRDM14_20953172_ChIP-Seq_ESCs_Human1.09914965
77ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09791964
78TP53_22573176_ChIP-Seq_HFKS_Human1.08503973
79AR_21572438_ChIP-Seq_LNCaP_Human1.07724361
80SMAD4_21741376_ChIP-Seq_EPCs_Human1.07174851
81* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06341072
82SOX2_21211035_ChIP-Seq_LN229_Gbm1.06260493
83KDM2B_26808549_Chip-Seq_REH_Human1.05614615
84RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05543939
85E2F1_18555785_Chip-Seq_ESCs_Mouse1.04825820
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03978471
87TAL1_26923725_Chip-Seq_HPCs_Mouse1.03584689
88P53_22387025_ChIP-Seq_ESCs_Mouse1.01102933
89KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01041349
90CDX2_22108803_ChIP-Seq_LS180_Human1.00175178
91TCF4_18268006_ChIP-ChIP_LS174T_Human0.99668289
92NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98036245
93STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97780351
94SMAD3_21741376_ChIP-Seq_HESCs_Human0.97587706
95BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97552962
96LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97525944
97CRX_20693478_ChIP-Seq_RETINA_Mouse0.97027228
98FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96875474
99TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96371686
100P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96346203

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002638_abnormal_pupillary_reflex2.99987972
2MP0006292_abnormal_olfactory_placode2.93436773
3MP0000569_abnormal_digit_pigmentation2.61379548
4MP0003787_abnormal_imprinting2.56984411
5MP0003880_abnormal_central_pattern2.50628486
6MP0008877_abnormal_DNA_methylation2.50280553
7MP0002102_abnormal_ear_morphology2.39488854
8MP0008789_abnormal_olfactory_epithelium2.27973437
9MP0008995_early_reproductive_senescence2.25551201
10MP0005394_taste/olfaction_phenotype2.25446841
11MP0005499_abnormal_olfactory_system2.25446841
12MP0006276_abnormal_autonomic_nervous2.08948505
13MP0000778_abnormal_nervous_system2.06653683
14MP0000427_abnormal_hair_cycle2.01833679
15MP0001984_abnormal_olfaction1.97201293
16MP0004133_heterotaxia1.91989737
17MP0003122_maternal_imprinting1.88430653
18MP0003195_calcinosis1.88014851
19MP0003890_abnormal_embryonic-extraembry1.86836710
20MP0002822_catalepsy1.82765654
21MP0000631_abnormal_neuroendocrine_gland1.72572741
22MP0005551_abnormal_eye_electrophysiolog1.71418803
23MP0000383_abnormal_hair_follicle1.70141433
24MP0005187_abnormal_penis_morphology1.69020236
25MP0002254_reproductive_system_inflammat1.67567234
26MP0000372_irregular_coat_pigmentation1.63194513
27MP0003121_genomic_imprinting1.56767362
28MP0005253_abnormal_eye_physiology1.55106410
29MP0002233_abnormal_nose_morphology1.52434333
30MP0002928_abnormal_bile_duct1.52040824
31MP0000647_abnormal_sebaceous_gland1.50811071
32MP0002938_white_spotting1.49786019
33MP0002653_abnormal_ependyma_morphology1.48370064
34MP0006072_abnormal_retinal_apoptosis1.44152039
35MP0004043_abnormal_pH_regulation1.43855275
36MP0003567_abnormal_fetal_cardiomyocyte1.43504204
37MP0001968_abnormal_touch/_nociception1.42833482
38MP0005646_abnormal_pituitary_gland1.41381748
39MP0003937_abnormal_limbs/digits/tail_de1.38592726
40MP0001986_abnormal_taste_sensitivity1.37650428
41MP0001529_abnormal_vocalization1.36999014
42MP0004142_abnormal_muscle_tone1.36851867
43MP0002837_dystrophic_cardiac_calcinosis1.35029582
44MP0001293_anophthalmia1.34763429
45MP0002735_abnormal_chemical_nociception1.32787732
46MP0002876_abnormal_thyroid_physiology1.30431355
47MP0002557_abnormal_social/conspecific_i1.29588382
48MP0001486_abnormal_startle_reflex1.27218617
49MP0003136_yellow_coat_color1.25053652
50MP0005645_abnormal_hypothalamus_physiol1.21034874
51MP0002751_abnormal_autonomic_nervous1.19447404
52MP0005367_renal/urinary_system_phenotyp1.15328084
53MP0000516_abnormal_urinary_system1.15328084
54MP0002272_abnormal_nervous_system1.14689405
55MP0002736_abnormal_nociception_after1.11447069
56MP0001485_abnormal_pinna_reflex1.11193929
57MP0006054_spinal_hemorrhage1.06083684
58MP0001286_abnormal_eye_development1.05395609
59MP0004924_abnormal_behavior1.04498037
60MP0005386_behavior/neurological_phenoty1.04498037
61MP0002752_abnormal_somatic_nervous1.04131166
62MP0002909_abnormal_adrenal_gland1.03520995
63MP0005391_vision/eye_phenotype1.02666427
64MP0000013_abnormal_adipose_tissue1.01280879
65MP0004270_analgesia1.01155884
66MP0002184_abnormal_innervation1.00172797
67MP0000639_abnormal_adrenal_gland0.99318198
68MP0004215_abnormal_myocardial_fiber0.98131194
69MP0002234_abnormal_pharynx_morphology0.97393333
70MP0002067_abnormal_sensory_capabilities0.96641458
71MP0004145_abnormal_muscle_electrophysio0.96091778
72MP0010678_abnormal_skin_adnexa0.94704320
73MP0009745_abnormal_behavioral_response0.93960417
74MP0010386_abnormal_urinary_bladder0.91891120
75MP0003938_abnormal_ear_development0.90579823
76MP0003283_abnormal_digestive_organ0.90268518
77MP0004085_abnormal_heartbeat0.89778570
78MP0005195_abnormal_posterior_eye0.89757681
79MP0009046_muscle_twitch0.88492286
80MP0000049_abnormal_middle_ear0.88162859
81MP0009384_cardiac_valve_regurgitation0.87943704
82MP0003698_abnormal_male_reproductive0.87793528
83MP0003221_abnormal_cardiomyocyte_apopto0.87386529
84MP0004885_abnormal_endolymph0.86283402
85MP0003935_abnormal_craniofacial_develop0.86236908
86MP0002882_abnormal_neuron_morphology0.85627019
87MP0008057_abnormal_DNA_replication0.84544671
88MP0002734_abnormal_mechanical_nocicepti0.82915682
89MP0003755_abnormal_palate_morphology0.82657358
90MP0002109_abnormal_limb_morphology0.82519916
91MP0001502_abnormal_circadian_rhythm0.82026268
92MP0003119_abnormal_digestive_system0.81896175
93MP0001299_abnormal_eye_distance/0.81128688
94MP0008775_abnormal_heart_ventricle0.79200803
95MP0001324_abnormal_eye_pigmentation0.79146857
96MP0002733_abnormal_thermal_nociception0.79010749
97MP0001929_abnormal_gametogenesis0.78591412
98MP0003137_abnormal_impulse_conducting0.76613139
99MP0002160_abnormal_reproductive_system0.76516458
100MP0002572_abnormal_emotion/affect_behav0.76234571

Predicted human phenotypes

RankGene SetZ-score
1Chronic hepatic failure (HP:0100626)4.08595216
2Hyperventilation (HP:0002883)3.77864126
3Pancreatic cysts (HP:0001737)3.76286756
4Medial flaring of the eyebrow (HP:0010747)3.67336162
5Abnormality of the renal cortex (HP:0011035)3.43020125
6True hermaphroditism (HP:0010459)3.36827107
7Nephrogenic diabetes insipidus (HP:0009806)3.34933880
8Pancreatic fibrosis (HP:0100732)3.28002382
9Gait imbalance (HP:0002141)3.26732776
10Nephronophthisis (HP:0000090)3.24630883
11Tubulointerstitial nephritis (HP:0001970)3.22083226
12Abnormality of midbrain morphology (HP:0002418)3.19920585
13Molar tooth sign on MRI (HP:0002419)3.19920585
14Renal cortical cysts (HP:0000803)3.19753167
15Congenital primary aphakia (HP:0007707)3.16624923
16Abnormality of the renal medulla (HP:0100957)3.08241319
17Drooling (HP:0002307)3.04643460
18Genital tract atresia (HP:0001827)2.94784429
19Vaginal atresia (HP:0000148)2.89755437
20Intestinal atresia (HP:0011100)2.82812947
21Excessive salivation (HP:0003781)2.80699709
22Poor coordination (HP:0002370)2.75773729
23Thyroid-stimulating hormone excess (HP:0002925)2.64646225
24Cupped ear (HP:0000378)2.62564837
25Gaze-evoked nystagmus (HP:0000640)2.61749682
26Cerebellar dysplasia (HP:0007033)2.53971971
27Aplasia/Hypoplasia of the tibia (HP:0005772)2.49382686
28Tubular atrophy (HP:0000092)2.45419315
29Hip dysplasia (HP:0001385)2.39192726
30Tubulointerstitial abnormality (HP:0001969)2.38799248
31Stomach cancer (HP:0012126)2.34221333
32Progressive cerebellar ataxia (HP:0002073)2.32508971
33Abnormality of the ischium (HP:0003174)2.26556921
34Genetic anticipation (HP:0003743)2.25301408
35Attenuation of retinal blood vessels (HP:0007843)2.24646387
36Lissencephaly (HP:0001339)2.23414019
37Absent speech (HP:0001344)2.22563661
38Oligodactyly (hands) (HP:0001180)2.22547253
39Hypoplastic ischia (HP:0003175)2.18903312
40Type II lissencephaly (HP:0007260)2.17999020
41Widely spaced teeth (HP:0000687)2.14364993
42Cutaneous finger syndactyly (HP:0010554)2.13892774
43Postaxial foot polydactyly (HP:0001830)2.12536768
44Disproportionate short-trunk short stature (HP:0003521)2.10419967
45Thyroiditis (HP:0100646)2.09322032
46Protruding tongue (HP:0010808)2.08926395
47Colon cancer (HP:0003003)2.08817996
48Short tibia (HP:0005736)2.08184134
49Bile duct proliferation (HP:0001408)2.07936449
50Abnormal biliary tract physiology (HP:0012439)2.07936449
51Short foot (HP:0001773)2.07205161
52Cystic liver disease (HP:0006706)2.06977139
53Broad-based gait (HP:0002136)2.06722553
54Congenital hepatic fibrosis (HP:0002612)2.06073416
55Hypoplastic iliac wings (HP:0002866)2.05632306
56Pachygyria (HP:0001302)2.03741779
57Abnormality of the pubic bones (HP:0003172)2.02234055
58Polydipsia (HP:0001959)2.01472599
59Abnormal drinking behavior (HP:0030082)2.01472599
60Optic nerve hypoplasia (HP:0000609)1.97785796
61Postaxial hand polydactyly (HP:0001162)1.97326701
62Specific learning disability (HP:0001328)1.96739779
63Tented upper lip vermilion (HP:0010804)1.94675018
64Hyperglycinemia (HP:0002154)1.94541442
65Inability to walk (HP:0002540)1.93388044
66Renal hypoplasia (HP:0000089)1.88937653
67Broad foot (HP:0001769)1.88318100
68Increased corneal curvature (HP:0100692)1.84150463
69Keratoconus (HP:0000563)1.84150463
70Volvulus (HP:0002580)1.83498850
71Progressive inability to walk (HP:0002505)1.83022578
72Narrow forehead (HP:0000341)1.81911300
73Male pseudohermaphroditism (HP:0000037)1.80862356
74Hypothermia (HP:0002045)1.80729242
75Aplasia/Hypoplasia of the tongue (HP:0010295)1.79960777
76Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.77863876
77Vitreoretinal degeneration (HP:0000655)1.76385971
78Aplasia/Hypoplasia of the lens (HP:0008063)1.76336006
79Truncal obesity (HP:0001956)1.74591366
80Astigmatism (HP:0000483)1.72643323
81Dyskinesia (HP:0100660)1.72197587
82Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.70998354
83Anencephaly (HP:0002323)1.70040375
84Hepatoblastoma (HP:0002884)1.69184301
85Abnormality of alanine metabolism (HP:0010916)1.68076867
86Hyperalaninemia (HP:0003348)1.68076867
87Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.68076867
88Abolished electroretinogram (ERG) (HP:0000550)1.67666082
89Decreased testicular size (HP:0008734)1.67235439
90Micropenis (HP:0000054)1.65448880
91Neoplasm of the tracheobronchial system (HP:0100552)1.65330328
92Small hand (HP:0200055)1.65140558
93Oculomotor apraxia (HP:0000657)1.64648043
94Cutaneous syndactyly (HP:0012725)1.62369064
95Abnormality of incisor morphology (HP:0011063)1.59536776
96Abnormality of the labia minora (HP:0012880)1.59320804
97Amyotrophic lateral sclerosis (HP:0007354)1.59153224
98Papillary thyroid carcinoma (HP:0002895)1.57921910
99Absent eyebrow (HP:0002223)1.57437344
100Anterior segment dysgenesis (HP:0007700)1.57212032

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.75371309
2BMPR1B3.11271493
3CASK2.91543560
4TRIM282.64530861
5MAP3K42.51735016
6BCR2.46386363
7AKT32.46076995
8EPHA32.33528576
9WNK32.23754219
10MAP4K22.23355787
11MAPK132.11011357
12TNIK2.04902778
13ACVR1B1.92701078
14STK38L1.90769342
15MARK11.90751639
16ADRBK21.69201199
17BRD41.60136785
18NLK1.46396606
19FGFR21.36899269
20MAP2K71.36339003
21NUAK11.33609967
22INSRR1.33087076
23OBSCN1.32205748
24ZAK1.28271852
25MAP3K71.25268003
26FLT31.24759668
27SGK21.22660503
28PAK31.18804701
29TAOK31.18510735
30BCKDK1.17244674
31PINK11.14109685
32OXSR11.13572601
33PKN21.11976603
34GRK11.06738284
35ERBB31.04718861
36STK391.04266327
37MKNK11.03197969
38EPHA41.02780862
39SIK21.01086642
40SGK2231.00027064
41SGK4941.00027064
42PLK20.99432485
43CSNK1G20.96704811
44CSNK1G10.95994520
45MKNK20.95143866
46CSNK1A1L0.93943185
47PRKCE0.93914170
48TGFBR10.93483644
49DYRK20.91149922
50FER0.83763017
51DYRK1A0.81343554
52DAPK20.77727989
53PIK3CG0.72975857
54NTRK20.72708247
55PTK2B0.69775381
56CAMK1G0.67319678
57MUSK0.67129406
58SIK30.66796485
59BRSK20.66781259
60PIK3CA0.65852412
61CAMKK20.62878221
62CSNK1G30.61556058
63STK110.61495760
64RPS6KA40.60789339
65CDK30.59404551
66ADRBK10.59127643
67IRAK10.58563788
68PRKAA10.58059452
69TXK0.57563782
70RPS6KA50.56235847
71SGK30.55288219
72PKN10.54988123
73PRKCG0.54973284
74CAMK1D0.52796831
75MARK30.52045054
76TLK10.51864457
77FGFR10.51507223
78CAMK10.51307632
79CHUK0.50284214
80CAMK40.48420916
81PRKAA20.47892525
82MAP2K40.47596764
83CDK80.46361671
84WNK40.45918890
85DYRK1B0.44977801
86CDK190.44373250
87PRKCZ0.42717669
88LATS10.42505159
89DYRK30.41063726
90CSNK1D0.40702192
91STK380.40166956
92YES10.38635029
93ERBB20.38230859
94TEC0.37942828
95PRKCQ0.37427251
96MAPKAPK50.37389224
97PRKACB0.37194706
98CAMK2A0.35008166
99TRPM70.34059581
100NTRK30.33831415

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.02069607
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.89592554
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.53187862
4Circadian rhythm_Homo sapiens_hsa047102.51591156
5Butanoate metabolism_Homo sapiens_hsa006502.38453372
6Nicotine addiction_Homo sapiens_hsa050332.28857760
7Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.07559161
8Linoleic acid metabolism_Homo sapiens_hsa005912.03007021
9Ether lipid metabolism_Homo sapiens_hsa005652.01600026
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.97827357
11Basal transcription factors_Homo sapiens_hsa030221.89586864
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.87702107
13Regulation of autophagy_Homo sapiens_hsa041401.86012455
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.85453545
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.79324088
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.77747354
17RNA degradation_Homo sapiens_hsa030181.73045823
18Fanconi anemia pathway_Homo sapiens_hsa034601.71246575
19Taste transduction_Homo sapiens_hsa047421.69904952
20ABC transporters_Homo sapiens_hsa020101.68445855
21Olfactory transduction_Homo sapiens_hsa047401.66118583
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60413368
23Selenocompound metabolism_Homo sapiens_hsa004501.53325534
24Peroxisome_Homo sapiens_hsa041461.42752290
25Ovarian steroidogenesis_Homo sapiens_hsa049131.42078324
26Nitrogen metabolism_Homo sapiens_hsa009101.40181359
27Propanoate metabolism_Homo sapiens_hsa006401.39848984
28Hedgehog signaling pathway_Homo sapiens_hsa043401.39353446
29Morphine addiction_Homo sapiens_hsa050321.34373272
30Lysine degradation_Homo sapiens_hsa003101.32703056
31Steroid biosynthesis_Homo sapiens_hsa001001.30729602
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.23745002
33Circadian entrainment_Homo sapiens_hsa047131.23437610
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17577315
35Glutamatergic synapse_Homo sapiens_hsa047241.16143212
36Dorso-ventral axis formation_Homo sapiens_hsa043201.12947692
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.12223945
38Insulin secretion_Homo sapiens_hsa049111.11897264
39GABAergic synapse_Homo sapiens_hsa047271.07304667
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.06663983
41Serotonergic synapse_Homo sapiens_hsa047261.06155418
42Type II diabetes mellitus_Homo sapiens_hsa049301.02989542
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.00322769
44Tryptophan metabolism_Homo sapiens_hsa003800.98630206
45Axon guidance_Homo sapiens_hsa043600.98125096
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98003571
47Protein export_Homo sapiens_hsa030600.97659581
48Steroid hormone biosynthesis_Homo sapiens_hsa001400.95730860
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94258484
50Dopaminergic synapse_Homo sapiens_hsa047280.91605107
51Long-term depression_Homo sapiens_hsa047300.88487345
52FoxO signaling pathway_Homo sapiens_hsa040680.83610027
53cAMP signaling pathway_Homo sapiens_hsa040240.80481290
54TGF-beta signaling pathway_Homo sapiens_hsa043500.80253871
55Basal cell carcinoma_Homo sapiens_hsa052170.77319897
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.76379820
57Aldosterone synthesis and secretion_Homo sapiens_hsa049250.74566193
58Hippo signaling pathway_Homo sapiens_hsa043900.74455776
59Cocaine addiction_Homo sapiens_hsa050300.73333867
60Cholinergic synapse_Homo sapiens_hsa047250.71455820
61Ras signaling pathway_Homo sapiens_hsa040140.69446186
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65225221
63Caffeine metabolism_Homo sapiens_hsa002320.61182091
64Vitamin digestion and absorption_Homo sapiens_hsa049770.60803617
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60488259
66Glycerophospholipid metabolism_Homo sapiens_hsa005640.59921537
67Salivary secretion_Homo sapiens_hsa049700.57944420
68Melanoma_Homo sapiens_hsa052180.56417946
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.55559204
70Retinol metabolism_Homo sapiens_hsa008300.55265515
71Protein digestion and absorption_Homo sapiens_hsa049740.54944659
72Oxytocin signaling pathway_Homo sapiens_hsa049210.53906143
73Calcium signaling pathway_Homo sapiens_hsa040200.53204308
74Wnt signaling pathway_Homo sapiens_hsa043100.52742185
75Inositol phosphate metabolism_Homo sapiens_hsa005620.50932133
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50868332
77Alcoholism_Homo sapiens_hsa050340.50057211
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.49436525
79Glycerolipid metabolism_Homo sapiens_hsa005610.47693009
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43958550
81Renin secretion_Homo sapiens_hsa049240.43931261
82Choline metabolism in cancer_Homo sapiens_hsa052310.42833693
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42004319
84mRNA surveillance pathway_Homo sapiens_hsa030150.41524888
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40619997
86Arachidonic acid metabolism_Homo sapiens_hsa005900.39924699
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38738684
88Amphetamine addiction_Homo sapiens_hsa050310.38175907
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38151100
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38106960
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36947300
92Prolactin signaling pathway_Homo sapiens_hsa049170.36295014
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35746686
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34774696
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34358559
96Collecting duct acid secretion_Homo sapiens_hsa049660.33680422
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33638232
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31838272
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31541042
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31532131

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »