ZNF138

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)4.31132350
2pyrimidine nucleobase catabolic process (GO:0006208)3.82732063
3chromatin remodeling at centromere (GO:0031055)3.66804644
4CENP-A containing nucleosome assembly (GO:0034080)3.57327126
5negative regulation of DNA recombination (GO:0045910)3.56761180
6cullin deneddylation (GO:0010388)3.40198370
7regulation of helicase activity (GO:0051095)3.32944159
8regulation of meiosis I (GO:0060631)3.31399590
9presynaptic membrane assembly (GO:0097105)3.31379005
10proteasome assembly (GO:0043248)3.27579073
11DNA ligation (GO:0006266)3.26344339
12positive regulation of mitochondrial fission (GO:0090141)3.22502154
13somatic diversification of immune receptors via somatic mutation (GO:0002566)3.18981418
14somatic hypermutation of immunoglobulin genes (GO:0016446)3.18981418
15histone exchange (GO:0043486)3.15220565
16synapsis (GO:0007129)3.13882295
17organelle disassembly (GO:1903008)3.05848676
18DNA damage response, detection of DNA damage (GO:0042769)3.04920537
19resolution of meiotic recombination intermediates (GO:0000712)3.03187972
20L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.99325146
21response to pheromone (GO:0019236)2.98810146
22DNA replication checkpoint (GO:0000076)2.98432165
23nucleobase catabolic process (GO:0046113)2.97636263
24neural tube formation (GO:0001841)2.97205585
25protein deneddylation (GO:0000338)2.93702930
26protein neddylation (GO:0045116)2.90727747
27establishment of integrated proviral latency (GO:0075713)2.89740406
28histone H2A acetylation (GO:0043968)2.87305169
29exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.86316467
30water-soluble vitamin biosynthetic process (GO:0042364)2.84161176
31DNA replication-independent nucleosome organization (GO:0034724)2.83352718
32DNA replication-independent nucleosome assembly (GO:0006336)2.83352718
33kinetochore assembly (GO:0051382)2.83112314
34nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.80649805
35presynaptic membrane organization (GO:0097090)2.78425168
36non-recombinational repair (GO:0000726)2.77629553
37double-strand break repair via nonhomologous end joining (GO:0006303)2.77629553
38intraciliary transport (GO:0042073)2.76404705
39DNA catabolic process, exonucleolytic (GO:0000738)2.76389262
40microtubule depolymerization (GO:0007019)2.75618573
41ribonucleoprotein complex disassembly (GO:0032988)2.74713343
42mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.72668671
43DNA integration (GO:0015074)2.71202625
44tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.67386727
45RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.67386727
46protein K6-linked ubiquitination (GO:0085020)2.65512457
47regulation of double-strand break repair via homologous recombination (GO:0010569)2.64865979
48nonmotile primary cilium assembly (GO:0035058)2.64217782
49mitotic spindle checkpoint (GO:0071174)2.63837015
50protein-cofactor linkage (GO:0018065)2.63702970
51replication fork processing (GO:0031297)2.63435955
52mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.62759269
53positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.62759269
54somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.60501633
55somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.60501633
56isotype switching (GO:0045190)2.60501633
57negative regulation of transcription regulatory region DNA binding (GO:2000678)2.60358879
58kinetochore organization (GO:0051383)2.60239923
59protein K11-linked ubiquitination (GO:0070979)2.59841721
60ubiquinone metabolic process (GO:0006743)2.58821267
61neuron cell-cell adhesion (GO:0007158)2.58071032
62spindle checkpoint (GO:0031577)2.56795914
63negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.55703046
64negative regulation of mitotic sister chromatid segregation (GO:0033048)2.55703046
65negative regulation of mitotic sister chromatid separation (GO:2000816)2.55703046
66negative regulation of sister chromatid segregation (GO:0033046)2.55703046
67negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.55703046
68regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.53985444
69regulation of mitotic spindle checkpoint (GO:1903504)2.53985444
70histone mRNA metabolic process (GO:0008334)2.53080931
71regulation of cilium movement (GO:0003352)2.50650104
72protein localization to cilium (GO:0061512)2.49644760
73negative regulation of chromosome segregation (GO:0051985)2.49356762
74L-methionine salvage (GO:0071267)2.48875573
75L-methionine biosynthetic process (GO:0071265)2.48875573
76amino acid salvage (GO:0043102)2.48875573
77tRNA aminoacylation (GO:0043039)2.48415317
78amino acid activation (GO:0043038)2.48415317
79mitochondrial RNA metabolic process (GO:0000959)2.47745443
80mitochondrial respiratory chain complex assembly (GO:0033108)2.47502056
81purine nucleobase biosynthetic process (GO:0009113)2.46055445
82tRNA aminoacylation for protein translation (GO:0006418)2.44372313
83mitotic spindle assembly checkpoint (GO:0007094)2.44247663
84postreplication repair (GO:0006301)2.44107638
85spindle assembly checkpoint (GO:0071173)2.43675280
86RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.42793956
87recombinational repair (GO:0000725)2.42598360
88sequestering of actin monomers (GO:0042989)2.42034067
89respiratory chain complex IV assembly (GO:0008535)2.41824932
90peptidyl-histidine modification (GO:0018202)2.41811693
91mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.41545898
92intra-S DNA damage checkpoint (GO:0031573)2.41373815
93protein complex biogenesis (GO:0070271)2.40828586
94regulation of mitochondrial translation (GO:0070129)2.39871873
95mismatch repair (GO:0006298)2.39849796
96chaperone-mediated protein transport (GO:0072321)2.38210444
97reciprocal DNA recombination (GO:0035825)2.38094557
98reciprocal meiotic recombination (GO:0007131)2.38094557
99energy coupled proton transport, down electrochemical gradient (GO:0015985)2.37650341
100ATP synthesis coupled proton transport (GO:0015986)2.37650341

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.55842593
2ZNF274_21170338_ChIP-Seq_K562_Hela3.05094852
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.03716893
4IGF1R_20145208_ChIP-Seq_DFB_Human2.93311007
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.88789291
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.85881793
7E2F7_22180533_ChIP-Seq_HELA_Human2.71149395
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.64238663
9* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.63169472
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.59948023
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.49677238
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.45434824
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.42143331
14ELK1_19687146_ChIP-ChIP_HELA_Human2.40635621
15FUS_26573619_Chip-Seq_HEK293_Human2.40321709
16EWS_26573619_Chip-Seq_HEK293_Human2.36820869
17VDR_22108803_ChIP-Seq_LS180_Human2.29404117
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.23342856
19TAF15_26573619_Chip-Seq_HEK293_Human2.19166443
20GBX2_23144817_ChIP-Seq_PC3_Human2.18887039
21RBPJ_22232070_ChIP-Seq_NCS_Mouse2.14699872
22PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12336397
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.04550186
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.03792146
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.02575602
26VDR_23849224_ChIP-Seq_CD4+_Human1.95049789
27ETS1_20019798_ChIP-Seq_JURKAT_Human1.90410248
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79196345
29P300_19829295_ChIP-Seq_ESCs_Human1.75071131
30PADI4_21655091_ChIP-ChIP_MCF-7_Human1.73484259
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.71543413
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70998036
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.70786206
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.68612334
35IRF1_19129219_ChIP-ChIP_H3396_Human1.66427743
36POU5F1_16153702_ChIP-ChIP_HESCs_Human1.62085562
37KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.60850980
38FOXP3_21729870_ChIP-Seq_TREG_Human1.59220242
39MYC_18940864_ChIP-ChIP_HL60_Human1.58565357
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56800265
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54120940
42MYC_18555785_ChIP-Seq_MESCs_Mouse1.51964596
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.48170713
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.45279106
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.43036138
46EZH2_22144423_ChIP-Seq_EOC_Human1.38825018
47SOX2_16153702_ChIP-ChIP_HESCs_Human1.37918311
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37416888
49DCP1A_22483619_ChIP-Seq_HELA_Human1.31892069
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28135803
51HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.27526311
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27253609
53CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.26855574
54ER_23166858_ChIP-Seq_MCF-7_Human1.26572786
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25917104
56GABP_19822575_ChIP-Seq_HepG2_Human1.23422571
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22662641
58TTF2_22483619_ChIP-Seq_HELA_Human1.22300825
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21940573
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21150301
61CBP_20019798_ChIP-Seq_JUKART_Human1.21150301
62NANOG_16153702_ChIP-ChIP_HESCs_Human1.19753167
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19187405
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.19045716
65RNF2_27304074_Chip-Seq_NSC_Mouse1.18385961
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17439874
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17115033
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16543252
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13505600
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12495191
71FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12126357
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.10267444
73MYC_19030024_ChIP-ChIP_MESCs_Mouse1.08760786
74KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08232030
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07028405
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05059105
77ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04790838
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04151319
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.04083706
80NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02671150
81RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02550471
82TP53_22573176_ChIP-Seq_HFKS_Human1.02030366
83SMAD4_21799915_ChIP-Seq_A2780_Human1.01293901
84SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01062789
85EZH2_27294783_Chip-Seq_NPCs_Mouse1.00719867
86MYCN_18555785_ChIP-Seq_MESCs_Mouse1.00258820
87NANOG_18555785_Chip-Seq_ESCs_Mouse0.98240260
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96911366
89E2F1_21310950_ChIP-Seq_MCF-7_Human0.95616570
90POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.95346490
91EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95147929
92E2F1_18555785_ChIP-Seq_MESCs_Mouse0.94719504
93SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94120571
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93994476
95MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.93465175
96MYC_18358816_ChIP-ChIP_MESCs_Mouse0.92402316
97PIAS1_25552417_ChIP-Seq_VCAP_Human0.92300429
98NANOG_19829295_ChIP-Seq_ESCs_Human0.92172492
99SOX2_19829295_ChIP-Seq_ESCs_Human0.92172492
100SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92007102

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair3.00835886
2MP0001529_abnormal_vocalization2.95635905
3MP0003880_abnormal_central_pattern2.93929698
4MP0008877_abnormal_DNA_methylation2.91168633
5MP0002102_abnormal_ear_morphology2.61678225
6MP0010094_abnormal_chromosome_stability2.51797040
7MP0005499_abnormal_olfactory_system2.49171802
8MP0005394_taste/olfaction_phenotype2.49171802
9MP0008789_abnormal_olfactory_epithelium2.43849090
10MP0003890_abnormal_embryonic-extraembry2.35968925
11MP0006292_abnormal_olfactory_placode2.24708041
12MP0001984_abnormal_olfaction2.13315600
13MP0008995_early_reproductive_senescence2.00588412
14MP0003693_abnormal_embryo_hatching1.90718544
15MP0001188_hyperpigmentation1.90122578
16MP0003121_genomic_imprinting1.88838524
17MP0005645_abnormal_hypothalamus_physiol1.87899837
18MP0003787_abnormal_imprinting1.86330807
19MP0006072_abnormal_retinal_apoptosis1.77708623
20MP0005187_abnormal_penis_morphology1.75123238
21MP0006276_abnormal_autonomic_nervous1.72707792
22MP0002938_white_spotting1.71170765
23MP0000778_abnormal_nervous_system1.69796811
24MP0004957_abnormal_blastocyst_morpholog1.69710158
25MP0003122_maternal_imprinting1.68610885
26MP0002822_catalepsy1.68279555
27MP0001293_anophthalmia1.65183179
28MP0003718_maternal_effect1.63585336
29MP0008932_abnormal_embryonic_tissue1.60894787
30MP0002751_abnormal_autonomic_nervous1.56992254
31MP0003136_yellow_coat_color1.56296150
32MP0005253_abnormal_eye_physiology1.50404729
33MP0002736_abnormal_nociception_after1.45709353
34MP0000647_abnormal_sebaceous_gland1.45127891
35MP0004147_increased_porphyrin_level1.44723743
36MP0006035_abnormal_mitochondrial_morpho1.38908097
37MP0001968_abnormal_touch/_nociception1.38868100
38MP0002234_abnormal_pharynx_morphology1.38707865
39MP0003567_abnormal_fetal_cardiomyocyte1.37622772
40MP0002233_abnormal_nose_morphology1.36351442
41MP0009046_muscle_twitch1.35331210
42MP0002638_abnormal_pupillary_reflex1.34110736
43MP0003786_premature_aging1.32468052
44MP0002160_abnormal_reproductive_system1.32001538
45MP0000631_abnormal_neuroendocrine_gland1.31822782
46MP0004133_heterotaxia1.31170351
47MP0003937_abnormal_limbs/digits/tail_de1.30015393
48MP0003111_abnormal_nucleus_morphology1.29366641
49MP0001986_abnormal_taste_sensitivity1.26686466
50MP0003077_abnormal_cell_cycle1.25956679
51MP0004270_analgesia1.24983016
52MP0005551_abnormal_eye_electrophysiolog1.21984277
53MP0009697_abnormal_copulation1.20370550
54MP0002653_abnormal_ependyma_morphology1.20063801
55MP0003221_abnormal_cardiomyocyte_apopto1.18769932
56MP0005075_abnormal_melanosome_morpholog1.16344176
57MP0003119_abnormal_digestive_system1.15444833
58MP0001286_abnormal_eye_development1.11505801
59MP0002210_abnormal_sex_determination1.11322686
60MP0002272_abnormal_nervous_system1.10374504
61MP0001486_abnormal_startle_reflex1.09607485
62MP0001929_abnormal_gametogenesis1.09021984
63MP0004142_abnormal_muscle_tone1.04687816
64MP0002734_abnormal_mechanical_nocicepti1.03436657
65MP0009745_abnormal_behavioral_response1.02912863
66MP0001485_abnormal_pinna_reflex1.02322867
67MP0000372_irregular_coat_pigmentation1.01918760
68MP0000049_abnormal_middle_ear1.01809822
69MP0002557_abnormal_social/conspecific_i1.00352228
70MP0008007_abnormal_cellular_replicative0.99609213
71MP0000653_abnormal_sex_gland0.98855650
72MP0003698_abnormal_male_reproductive0.97900745
73MP0005391_vision/eye_phenotype0.97498959
74MP0003861_abnormal_nervous_system0.96548419
75MP0002184_abnormal_innervation0.96469458
76MP0001145_abnormal_male_reproductive0.95586760
77MP0003635_abnormal_synaptic_transmissio0.93431023
78MP0002752_abnormal_somatic_nervous0.91762062
79MP0000955_abnormal_spinal_cord0.90943389
80MP0002735_abnormal_chemical_nociception0.90405432
81MP0005084_abnormal_gallbladder_morpholo0.90114093
82MP0002572_abnormal_emotion/affect_behav0.87238175
83MP0002095_abnormal_skin_pigmentation0.86890659
84MP0005423_abnormal_somatic_nervous0.86513879
85MP0001177_atelectasis0.84885132
86MP0002067_abnormal_sensory_capabilities0.84402885
87MP0008057_abnormal_DNA_replication0.83483109
88MP0005386_behavior/neurological_phenoty0.83035935
89MP0004924_abnormal_behavior0.83035935
90MP0004811_abnormal_neuron_physiology0.82729862
91MP0002090_abnormal_vision0.82679380
92MP0005389_reproductive_system_phenotype0.82026825
93MP0000569_abnormal_digit_pigmentation0.81857925
94MP0002063_abnormal_learning/memory/cond0.80339910
95MP0005248_abnormal_Harderian_gland0.79914209
96MP0001119_abnormal_female_reproductive0.79207555
97MP0006036_abnormal_mitochondrial_physio0.79043443
98MP0002882_abnormal_neuron_morphology0.79042656
99MP0002084_abnormal_developmental_patter0.78628410
100MP0004197_abnormal_fetal_growth/weight/0.77142494

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)3.46665782
2Colon cancer (HP:0003003)3.30179204
3Methylmalonic acidemia (HP:0002912)2.97073527
4Hyperglycinemia (HP:0002154)2.90676232
5Medial flaring of the eyebrow (HP:0010747)2.86100868
6Gait imbalance (HP:0002141)2.78503410
7Cortical dysplasia (HP:0002539)2.77437061
8Congenital primary aphakia (HP:0007707)2.76250950
9Nephrogenic diabetes insipidus (HP:0009806)2.70955439
10Aplasia/Hypoplasia of the uvula (HP:0010293)2.66998590
11Meckel diverticulum (HP:0002245)2.63147962
12Abnormality of chromosome stability (HP:0003220)2.58514090
13Pancreatic fibrosis (HP:0100732)2.56058008
14True hermaphroditism (HP:0010459)2.56033257
15Acute necrotizing encephalopathy (HP:0006965)2.52309152
16Genital tract atresia (HP:0001827)2.52162757
17Abnormality of the ileum (HP:0001549)2.51934549
18Acute encephalopathy (HP:0006846)2.50905423
19Medulloblastoma (HP:0002885)2.50589193
20Pancreatic cysts (HP:0001737)2.44222778
21Chromosomal breakage induced by crosslinking agents (HP:0003221)2.41396257
22Septo-optic dysplasia (HP:0100842)2.38705526
23Vaginal atresia (HP:0000148)2.38684551
24Increased hepatocellular lipid droplets (HP:0006565)2.35631288
25Progressive macrocephaly (HP:0004481)2.28070626
26Chronic hepatic failure (HP:0100626)2.25417132
27Methylmalonic aciduria (HP:0012120)2.25191506
28Abnormal mitochondria in muscle tissue (HP:0008316)2.24126321
29Chromsome breakage (HP:0040012)2.22860613
303-Methylglutaconic aciduria (HP:0003535)2.18402653
31Abnormality of serum amino acid levels (HP:0003112)2.17196509
32Pendular nystagmus (HP:0012043)2.16905961
33Lipid accumulation in hepatocytes (HP:0006561)2.16793031
34Increased CSF lactate (HP:0002490)2.16359109
35Abnormality of the preputium (HP:0100587)2.15121092
36Abnormality of glycine metabolism (HP:0010895)2.14948293
37Abnormality of serine family amino acid metabolism (HP:0010894)2.14948293
38Nephronophthisis (HP:0000090)2.13371902
39Abnormal lung lobation (HP:0002101)2.11682915
40Intestinal atresia (HP:0011100)2.11642848
41Hyperglycinuria (HP:0003108)2.11430054
42Small intestinal stenosis (HP:0012848)2.07213751
43Duodenal stenosis (HP:0100867)2.07213751
44Mitochondrial inheritance (HP:0001427)2.06130098
45Molar tooth sign on MRI (HP:0002419)2.05769515
46Abnormality of midbrain morphology (HP:0002418)2.05769515
47Aplasia/Hypoplasia of the tibia (HP:0005772)2.03630289
48Ependymoma (HP:0002888)2.03105807
49Short tibia (HP:0005736)2.00274727
50Renal cortical cysts (HP:0000803)1.98922439
51Triphalangeal thumb (HP:0001199)1.98515381
52Drooling (HP:0002307)1.98413020
53Glioma (HP:0009733)1.98158090
54Poor coordination (HP:0002370)1.97778405
55Abnormality of alanine metabolism (HP:0010916)1.97259889
56Hyperalaninemia (HP:0003348)1.97259889
57Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.97259889
58Sloping forehead (HP:0000340)1.94402781
59Absent eyebrow (HP:0002223)1.92442511
60Abnormality of the duodenum (HP:0002246)1.92210876
61Amyotrophic lateral sclerosis (HP:0007354)1.89667386
62Astrocytoma (HP:0009592)1.88632039
63Abnormality of the astrocytes (HP:0100707)1.88632039
64Abnormality of the vitamin B12 metabolism (HP:0004341)1.86825574
65Postaxial foot polydactyly (HP:0001830)1.86272409
66Progressive inability to walk (HP:0002505)1.85787034
67Postaxial hand polydactyly (HP:0001162)1.85186506
68Specific learning disability (HP:0001328)1.84895121
69Astigmatism (HP:0000483)1.82753852
70Retinal dysplasia (HP:0007973)1.82134178
71Atrophy/Degeneration involving motor neurons (HP:0007373)1.81149471
72Oligodactyly (hands) (HP:0001180)1.80813055
73Lissencephaly (HP:0001339)1.80389577
74Hepatocellular necrosis (HP:0001404)1.79945965
75Polyphagia (HP:0002591)1.78166692
76Hepatoblastoma (HP:0002884)1.77392733
77Broad foot (HP:0001769)1.76424674
78Abnormality of homocysteine metabolism (HP:0010919)1.74989575
79Homocystinuria (HP:0002156)1.74989575
80Abnormality of vitamin B metabolism (HP:0004340)1.74967876
81Increased serum lactate (HP:0002151)1.74700334
82Optic nerve hypoplasia (HP:0000609)1.73303381
83Excessive salivation (HP:0003781)1.73080063
84Volvulus (HP:0002580)1.72621685
85Hepatic necrosis (HP:0002605)1.72299421
86Aplasia/Hypoplasia of the tongue (HP:0010295)1.71912491
87Hyperventilation (HP:0002883)1.71528240
88Abnormality of the carotid arteries (HP:0005344)1.71084224
89Cerebral edema (HP:0002181)1.69893847
90Abnormality of the renal medulla (HP:0100957)1.69598328
91Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.69208155
92Supernumerary spleens (HP:0009799)1.66713156
93Aplasia/Hypoplasia of the sternum (HP:0006714)1.66465273
94Increased serum pyruvate (HP:0003542)1.65214677
95Abolished electroretinogram (ERG) (HP:0000550)1.64035714
96Anencephaly (HP:0002323)1.63657569
97Patellar aplasia (HP:0006443)1.63147602
98Broad-based gait (HP:0002136)1.63074954
99Absent septum pellucidum (HP:0001331)1.62176109
100Decreased testicular size (HP:0008734)1.61325603

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK33.52018721
2TRIM283.06442790
3SRPK12.98062184
4BCR2.90465171
5MAP3K42.59905655
6MAP4K22.11847490
7MAP2K72.00560961
8ERBB32.00286248
9CASK1.96389034
10TSSK61.91229185
11EIF2AK31.89696371
12ZAK1.86637249
13WEE11.83629607
14PLK41.81930275
15MKNK21.81164451
16MKNK11.78692142
17FRK1.72406282
18VRK11.71805202
19MARK11.70159383
20NUAK11.67550580
21CDC71.65788048
22PLK31.65252231
23DYRK21.64525414
24BUB11.63362121
25MAPK131.63269582
26CSNK1G21.62966681
27BMPR1B1.62293910
28NEK11.62208842
29CDK191.59026728
30CSNK1G31.58257453
31CSNK1G11.56315846
32CSNK1A1L1.52833058
33PINK11.43981595
34PLK21.40035942
35DYRK31.38637719
36EPHA41.35470683
37TTK1.33166777
38PBK1.28272154
39PLK11.22438367
40BRSK21.20997472
41TNIK1.20764422
42BCKDK1.19676054
43RPS6KA41.16920112
44STK161.13878311
45CCNB11.13068623
46VRK21.07546892
47ACVR1B1.06757041
48MINK10.98936634
49NTRK20.95161379
50GRK10.91310094
51OXSR10.88381521
52SIK30.87077432
53ATR0.85448931
54MAP2K40.83523288
55STK38L0.81803378
56ADRBK20.80928559
57TAF10.76707379
58NME10.73766776
59EIF2AK10.73175789
60PNCK0.71218606
61FLT30.70081579
62PRKCG0.69907712
63ATM0.65831486
64MST40.65153769
65PRKCE0.65026384
66CDK30.61535025
67INSRR0.60241721
68AURKB0.57278575
69PAK30.56546129
70PASK0.55975672
71NTRK30.54184732
72KSR10.53918914
73FGFR20.53656280
74EIF2AK20.53096151
75BRSK10.52911117
76MAP3K120.52892798
77DYRK1A0.52118154
78RPS6KA50.50322471
79STK390.48899171
80CSNK1D0.47524240
81MAP3K50.45522806
82FER0.43680380
83CAMK2A0.42430197
84OBSCN0.42426584
85CHEK20.42303501
86CSNK2A10.42195187
87BRD40.42061090
88PIK3CA0.40784281
89CDK140.39750561
90CSNK1E0.39310221
91CHEK10.38773500
92CSNK1A10.36666391
93TGFBR10.35647337
94WNK40.34455560
95AURKA0.34217021
96CLK10.34090864
97CSNK2A20.33488102
98CDK10.33229696
99CDK180.33169453
100PRKDC0.32619404

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030602.99295960
2Mismatch repair_Homo sapiens_hsa034302.95808964
3Non-homologous end-joining_Homo sapiens_hsa034502.71550635
4Fanconi anemia pathway_Homo sapiens_hsa034602.51201144
5Oxidative phosphorylation_Homo sapiens_hsa001902.50636108
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.42099589
7Homologous recombination_Homo sapiens_hsa034402.39921650
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.35023295
9Parkinsons disease_Homo sapiens_hsa050122.31679639
10Basal transcription factors_Homo sapiens_hsa030222.28042817
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.27554011
12Proteasome_Homo sapiens_hsa030502.21907211
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.14336333
14RNA polymerase_Homo sapiens_hsa030202.13376522
15Nicotine addiction_Homo sapiens_hsa050332.07007878
16Steroid biosynthesis_Homo sapiens_hsa001002.00326902
17Propanoate metabolism_Homo sapiens_hsa006401.99896516
18RNA transport_Homo sapiens_hsa030131.93640784
19DNA replication_Homo sapiens_hsa030301.92473323
20RNA degradation_Homo sapiens_hsa030181.89141792
21Spliceosome_Homo sapiens_hsa030401.87285377
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.79263081
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.75252441
24Huntingtons disease_Homo sapiens_hsa050161.66731178
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.57915547
26Butanoate metabolism_Homo sapiens_hsa006501.56653431
27Nucleotide excision repair_Homo sapiens_hsa034201.55801111
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.55664933
29Base excision repair_Homo sapiens_hsa034101.55432630
30Phototransduction_Homo sapiens_hsa047441.40251026
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39797354
32One carbon pool by folate_Homo sapiens_hsa006701.35691041
33Cell cycle_Homo sapiens_hsa041101.32857991
34Alzheimers disease_Homo sapiens_hsa050101.32720359
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.30543051
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.30345982
37Fatty acid elongation_Homo sapiens_hsa000621.22417949
38Taste transduction_Homo sapiens_hsa047421.17545979
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.15667934
40Oocyte meiosis_Homo sapiens_hsa041141.14847368
41Ribosome_Homo sapiens_hsa030101.12802533
42GABAergic synapse_Homo sapiens_hsa047271.12442107
43Peroxisome_Homo sapiens_hsa041461.08971495
44Regulation of autophagy_Homo sapiens_hsa041401.07688792
45mRNA surveillance pathway_Homo sapiens_hsa030151.02189047
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01206750
47Pyrimidine metabolism_Homo sapiens_hsa002401.00347056
48Pyruvate metabolism_Homo sapiens_hsa006200.94166046
49Purine metabolism_Homo sapiens_hsa002300.91600071
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90581256
51Selenocompound metabolism_Homo sapiens_hsa004500.89379403
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.87550587
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85783684
54Folate biosynthesis_Homo sapiens_hsa007900.84350173
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82805431
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79739969
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77588718
58Cardiac muscle contraction_Homo sapiens_hsa042600.77247564
59p53 signaling pathway_Homo sapiens_hsa041150.75257848
60Morphine addiction_Homo sapiens_hsa050320.75210411
61Olfactory transduction_Homo sapiens_hsa047400.74547088
62Collecting duct acid secretion_Homo sapiens_hsa049660.73881603
63Metabolic pathways_Homo sapiens_hsa011000.68837959
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.63762020
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61839124
66Carbon metabolism_Homo sapiens_hsa012000.61342406
67Caffeine metabolism_Homo sapiens_hsa002320.59466868
68Biosynthesis of amino acids_Homo sapiens_hsa012300.59055411
69Alcoholism_Homo sapiens_hsa050340.57530672
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56882267
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53349438
72Dopaminergic synapse_Homo sapiens_hsa047280.52548826
73Hedgehog signaling pathway_Homo sapiens_hsa043400.51426628
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50452515
75Glutamatergic synapse_Homo sapiens_hsa047240.50197709
76Nitrogen metabolism_Homo sapiens_hsa009100.49932940
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49253801
78Fatty acid metabolism_Homo sapiens_hsa012120.48889890
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48735798
80Circadian entrainment_Homo sapiens_hsa047130.47590934
81Synaptic vesicle cycle_Homo sapiens_hsa047210.46464828
82Glutathione metabolism_Homo sapiens_hsa004800.43419703
83Circadian rhythm_Homo sapiens_hsa047100.43237352
84Basal cell carcinoma_Homo sapiens_hsa052170.42266124
85Serotonergic synapse_Homo sapiens_hsa047260.41091079
86Tryptophan metabolism_Homo sapiens_hsa003800.40379484
87Linoleic acid metabolism_Homo sapiens_hsa005910.39798861
88Hippo signaling pathway_Homo sapiens_hsa043900.38635735
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38522283
90Wnt signaling pathway_Homo sapiens_hsa043100.36295572
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36170434
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35633611
93Amphetamine addiction_Homo sapiens_hsa050310.34276031
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33381862
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32755820
96Retinol metabolism_Homo sapiens_hsa008300.29713119
97Ether lipid metabolism_Homo sapiens_hsa005650.28946973
98Vitamin B6 metabolism_Homo sapiens_hsa007500.28730666
99beta-Alanine metabolism_Homo sapiens_hsa004100.27333298
100Cocaine addiction_Homo sapiens_hsa050300.25923532

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