ZNF112

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.14676558
2DNA integration (GO:0015074)4.24498194
3nucleobase catabolic process (GO:0046113)4.11144767
4negative regulation of synaptic transmission, GABAergic (GO:0032229)3.63818673
5negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.58777036
6presynaptic membrane assembly (GO:0097105)3.40699957
7intraciliary transport (GO:0042073)3.34558754
8calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.30332877
9neuron cell-cell adhesion (GO:0007158)3.23159942
10gamma-aminobutyric acid transport (GO:0015812)3.21592464
11ganglion development (GO:0061548)3.16181246
12microtubule depolymerization (GO:0007019)3.13376381
13axonal fasciculation (GO:0007413)3.09729859
14olfactory bulb development (GO:0021772)3.09682873
15mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.98377331
16positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.98377331
17positive regulation of macrophage activation (GO:0043032)2.97292251
18limb bud formation (GO:0060174)2.93988363
19cerebral cortex radially oriented cell migration (GO:0021799)2.92222214
20response to pheromone (GO:0019236)2.88933065
21central nervous system projection neuron axonogenesis (GO:0021952)2.86569438
22negative regulation of axon guidance (GO:1902668)2.83596459
23ribonucleoprotein complex disassembly (GO:0032988)2.82155919
24presynaptic membrane organization (GO:0097090)2.81469902
25establishment of melanosome localization (GO:0032401)2.79409312
26regulation of cilium movement (GO:0003352)2.79137270
27establishment of mitochondrion localization (GO:0051654)2.76757971
28spermatid nucleus differentiation (GO:0007289)2.76713832
29water-soluble vitamin biosynthetic process (GO:0042364)2.76356672
30cellular response to cholesterol (GO:0071397)2.75362368
31cornea development in camera-type eye (GO:0061303)2.73701599
32glycosphingolipid biosynthetic process (GO:0006688)2.72723793
33melanosome transport (GO:0032402)2.71669069
34neuron recognition (GO:0008038)2.70201337
35cilium morphogenesis (GO:0060271)2.69799308
36establishment of pigment granule localization (GO:0051905)2.69015621
37anterograde synaptic vesicle transport (GO:0048490)2.68345784
38neuronal action potential propagation (GO:0019227)2.68026829
39behavioral response to ethanol (GO:0048149)2.67738359
40epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.65843457
41G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.65507156
42nonmotile primary cilium assembly (GO:0035058)2.65049254
43positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.61522090
44pigment granule transport (GO:0051904)2.61154767
45synapse assembly (GO:0007416)2.58197506
46positive regulation of chemokine secretion (GO:0090197)2.58042093
47neurotransmitter-gated ion channel clustering (GO:0072578)2.57341711
48cullin deneddylation (GO:0010388)2.56586075
49cellular response to sterol (GO:0036315)2.55989855
50somite development (GO:0061053)2.54777916
51central nervous system neuron axonogenesis (GO:0021955)2.53579032
52intra-Golgi vesicle-mediated transport (GO:0006891)2.53570400
53histone H2A acetylation (GO:0043968)2.52244459
54resolution of meiotic recombination intermediates (GO:0000712)2.49763737
55neural tube formation (GO:0001841)2.49529553
56melanosome localization (GO:0032400)2.47111092
57protein localization to cilium (GO:0061512)2.46882893
58cilium or flagellum-dependent cell motility (GO:0001539)2.46283909
59epithelial cilium movement (GO:0003351)2.46247028
60postsynaptic membrane organization (GO:0001941)2.44234050
61cytoskeleton-dependent intracellular transport (GO:0030705)2.44160889
62preassembly of GPI anchor in ER membrane (GO:0016254)2.44048826
63GPI anchor metabolic process (GO:0006505)2.43955455
64mannosylation (GO:0097502)2.43826771
65cerebral cortex cell migration (GO:0021795)2.43575420
66head development (GO:0060322)2.43275719
67otic vesicle formation (GO:0030916)2.43159586
68acrosome reaction (GO:0007340)2.41966390
69cilium assembly (GO:0042384)2.41174784
70L-serine transport (GO:0015825)2.41016351
71cilium organization (GO:0044782)2.40146163
72establishment of protein localization to Golgi (GO:0072600)2.39950160
73cochlea development (GO:0090102)2.39851701
74pigment granule localization (GO:0051875)2.38840826
75microtubule-based transport (GO:0010970)2.38701761
76protein targeting to Golgi (GO:0000042)2.38331663
77photoreceptor cell maintenance (GO:0045494)2.35465806
78vesicle localization (GO:0051648)2.33653981
79C-terminal protein amino acid modification (GO:0018410)2.33407061
80negative regulation of DNA recombination (GO:0045910)2.32466185
81cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.32386509
82protein polyglutamylation (GO:0018095)2.30965036
83vesicle transport along microtubule (GO:0047496)2.30444039
84regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.29528226
85homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.28657853
86protein deneddylation (GO:0000338)2.28149512
87negative regulation of dendrite development (GO:2000171)2.27187927
88vocalization behavior (GO:0071625)2.27070692
89regulation of axon guidance (GO:1902667)2.26897828
90negative regulation of axon extension involved in axon guidance (GO:0048843)2.25878143
91organelle disassembly (GO:1903008)2.25735967
92retinal rod cell development (GO:0046548)2.25218759
93auditory behavior (GO:0031223)2.24952428
94synaptic vesicle maturation (GO:0016188)2.23958737
95organelle transport along microtubule (GO:0072384)2.22358782
96regulation of feeding behavior (GO:0060259)2.22262142
97positive regulation of dendritic spine morphogenesis (GO:0061003)2.21677897
98C-terminal protein lipidation (GO:0006501)2.21253724
99histone H2A ubiquitination (GO:0033522)2.21096376
100reflex (GO:0060004)2.20995498

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human3.41572312
2ZNF274_21170338_ChIP-Seq_K562_Hela3.31336813
3IGF1R_20145208_ChIP-Seq_DFB_Human3.30050791
4GBX2_23144817_ChIP-Seq_PC3_Human3.09056540
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.87588225
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.72249356
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.63935892
8FUS_26573619_Chip-Seq_HEK293_Human2.58745155
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.47507394
10EZH2_22144423_ChIP-Seq_EOC_Human2.42203095
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.40995928
12TAF15_26573619_Chip-Seq_HEK293_Human2.39660858
13EWS_26573619_Chip-Seq_HEK293_Human2.14049761
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.09668732
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07168022
16P300_19829295_ChIP-Seq_ESCs_Human1.91708899
17SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.88625911
18SMAD4_21799915_ChIP-Seq_A2780_Human1.81781504
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.81499235
20VDR_22108803_ChIP-Seq_LS180_Human1.81026654
21OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.80084776
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.78486000
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.77053732
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76119634
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.74506930
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73806476
27MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.71833825
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71606467
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71455399
30PIAS1_25552417_ChIP-Seq_VCAP_Human1.68226211
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.67612166
32SMAD3_21741376_ChIP-Seq_EPCs_Human1.65333599
33ELK1_19687146_ChIP-ChIP_HELA_Human1.63790503
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63541004
35GABP_17652178_ChIP-ChIP_JURKAT_Human1.54849403
36SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50675624
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48925380
38CBP_20019798_ChIP-Seq_JUKART_Human1.48925380
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45869368
40TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45765128
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.45615617
42ER_23166858_ChIP-Seq_MCF-7_Human1.41697802
43RNF2_27304074_Chip-Seq_NSC_Mouse1.39075457
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38488013
45STAT3_23295773_ChIP-Seq_U87_Human1.37749734
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.36872898
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34907949
48NANOG_18555785_Chip-Seq_ESCs_Mouse1.34023481
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32369732
50KLF5_20875108_ChIP-Seq_MESCs_Mouse1.30088965
51TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.29798746
52RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.29344712
53EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25858361
54AR_25329375_ChIP-Seq_VCAP_Human1.25187272
55JUN_21703547_ChIP-Seq_K562_Human1.24132006
56TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23368498
57FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.22115235
58SOX9_26525672_Chip-Seq_HEART_Mouse1.21637385
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20978659
60NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20635286
61KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.19150711
62TCF4_23295773_ChIP-Seq_U87_Human1.17953631
63CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17636169
64RUNX2_22187159_ChIP-Seq_PCA_Human1.16290746
65KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14001405
66TAL1_26923725_Chip-Seq_HPCs_Mouse1.13760178
67POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13232802
68SOX2_16153702_ChIP-ChIP_HESCs_Human1.12534848
69MYC_18940864_ChIP-ChIP_HL60_Human1.11057993
70MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.08399649
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08124539
72TP53_18474530_ChIP-ChIP_U2OS_Human1.07405644
73P53_22387025_ChIP-Seq_ESCs_Mouse1.07261473
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.06908034
75HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06071333
76EST1_17652178_ChIP-ChIP_JURKAT_Human1.05671903
77TCF4_22108803_ChIP-Seq_LS180_Human1.04693989
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04654505
79PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02305118
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00808999
81TP63_19390658_ChIP-ChIP_HaCaT_Human1.00372566
82LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99098680
83E2F1_18555785_Chip-Seq_ESCs_Mouse0.98518286
84TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98066530
85TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98001371
86CMYC_18555785_Chip-Seq_ESCs_Mouse0.97852637
87REST_21632747_ChIP-Seq_MESCs_Mouse0.96789350
88BCAT_22108803_ChIP-Seq_LS180_Human0.96042919
89IRF1_19129219_ChIP-ChIP_H3396_Human0.95979362
90SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95593860
91SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.95166318
92STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.93695303
93POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.93363628
94EZH2_27304074_Chip-Seq_ESCs_Mouse0.92899112
95TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92774514
96CREB1_15753290_ChIP-ChIP_HEK293T_Human0.92375394
97SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.92169621
98STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92131902
99AUTS2_25519132_ChIP-Seq_293T-REX_Human0.91987689
100NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91941659

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.23191086
2MP0005187_abnormal_penis_morphology2.76346935
3MP0000778_abnormal_nervous_system2.56734211
4MP0006292_abnormal_olfactory_placode2.49086589
5MP0002102_abnormal_ear_morphology2.38823245
6MP0001984_abnormal_olfaction2.26112319
7MP0008789_abnormal_olfactory_epithelium2.25476968
8MP0002234_abnormal_pharynx_morphology2.18960313
9MP0005499_abnormal_olfactory_system2.15647754
10MP0005394_taste/olfaction_phenotype2.15647754
11MP0001529_abnormal_vocalization2.12419080
12MP0001299_abnormal_eye_distance/2.04469202
13MP0006276_abnormal_autonomic_nervous1.91985173
14MP0000569_abnormal_digit_pigmentation1.82196660
15MP0008877_abnormal_DNA_methylation1.81217160
16MP0006072_abnormal_retinal_apoptosis1.75986144
17MP0004270_analgesia1.70751196
18MP0009046_muscle_twitch1.65934258
19MP0003787_abnormal_imprinting1.64444792
20MP0002233_abnormal_nose_morphology1.60467693
21MP0002751_abnormal_autonomic_nervous1.60231055
22MP0004859_abnormal_synaptic_plasticity1.59146127
23MP0005253_abnormal_eye_physiology1.52995840
24MP0003122_maternal_imprinting1.49068517
25MP0000631_abnormal_neuroendocrine_gland1.47403102
26MP0001293_anophthalmia1.45941000
27MP0003136_yellow_coat_color1.42285168
28MP0005645_abnormal_hypothalamus_physiol1.41647428
29MP0005248_abnormal_Harderian_gland1.41469852
30MP0002184_abnormal_innervation1.41215881
31MP0000049_abnormal_middle_ear1.40833944
32MP0002736_abnormal_nociception_after1.40618558
33MP0003755_abnormal_palate_morphology1.39164722
34MP0003121_genomic_imprinting1.38569848
35MP0003221_abnormal_cardiomyocyte_apopto1.36997834
36MP0004133_heterotaxia1.35462350
37MP0003937_abnormal_limbs/digits/tail_de1.34891265
38MP0002938_white_spotting1.31030991
39MP0003315_abnormal_perineum_morphology1.26358736
40MP0000647_abnormal_sebaceous_gland1.24369945
41MP0002734_abnormal_mechanical_nocicepti1.24077855
42MP0003635_abnormal_synaptic_transmissio1.23192325
43MP0002272_abnormal_nervous_system1.22091308
44MP0005171_absent_coat_pigmentation1.21185152
45MP0000372_irregular_coat_pigmentation1.18549040
46MP0009745_abnormal_behavioral_response1.17791790
47MP0004811_abnormal_neuron_physiology1.15529515
48MP0009697_abnormal_copulation1.15324860
49MP0004147_increased_porphyrin_level1.15267530
50MP0000955_abnormal_spinal_cord1.14574448
51MP0004215_abnormal_myocardial_fiber1.14182570
52MP0002909_abnormal_adrenal_gland1.13290792
53MP0004885_abnormal_endolymph1.12733176
54MP0003567_abnormal_fetal_cardiomyocyte1.12342451
55MP0005670_abnormal_white_adipose1.10193255
56MP0001486_abnormal_startle_reflex1.07145301
57MP0002752_abnormal_somatic_nervous1.07026743
58MP0001968_abnormal_touch/_nociception1.06890188
59MP0003385_abnormal_body_wall1.06506680
60MP0005551_abnormal_eye_electrophysiolog1.06229612
61MP0003861_abnormal_nervous_system1.05831473
62MP0002572_abnormal_emotion/affect_behav1.05641997
63MP0005391_vision/eye_phenotype1.04327152
64MP0002638_abnormal_pupillary_reflex1.03056723
65MP0002067_abnormal_sensory_capabilities1.02369006
66MP0002557_abnormal_social/conspecific_i1.02365154
67MP0002882_abnormal_neuron_morphology1.02076005
68MP0002063_abnormal_learning/memory/cond1.00727281
69MP0002064_seizures1.00066810
70MP0000026_abnormal_inner_ear0.98669965
71MP0003950_abnormal_plasma_membrane0.98350807
72MP0004924_abnormal_behavior0.98145660
73MP0005386_behavior/neurological_phenoty0.98145660
74MP0004142_abnormal_muscle_tone0.97992502
75MP0009053_abnormal_anal_canal0.97758384
76MP0002653_abnormal_ependyma_morphology0.97423812
77MP0002928_abnormal_bile_duct0.96824528
78MP0003119_abnormal_digestive_system0.96576940
79MP0002735_abnormal_chemical_nociception0.96215227
80MP0003935_abnormal_craniofacial_develop0.95851790
81MP0002697_abnormal_eye_size0.93564713
82MP0002177_abnormal_outer_ear0.92766589
83MP0005195_abnormal_posterior_eye0.92576126
84MP0002152_abnormal_brain_morphology0.92537802
85MP0002160_abnormal_reproductive_system0.89968107
86MP0000427_abnormal_hair_cycle0.89802128
87MP0005423_abnormal_somatic_nervous0.88097827
88MP0001286_abnormal_eye_development0.87591544
89MP0001986_abnormal_taste_sensitivity0.86637770
90MP0000566_synostosis0.86075312
91MP0010368_abnormal_lymphatic_system0.85351495
92MP0003890_abnormal_embryonic-extraembry0.80761459
93MP0001188_hyperpigmentation0.80757290
94MP0002282_abnormal_trachea_morphology0.79483815
95MP0001177_atelectasis0.78754459
96MP0003698_abnormal_male_reproductive0.78447885
97MP0000383_abnormal_hair_follicle0.78104338
98MP0008058_abnormal_DNA_repair0.74972495
99MP0003011_delayed_dark_adaptation0.73332991
100MP0004085_abnormal_heartbeat0.71550764

Predicted human phenotypes

RankGene SetZ-score
1Nephrogenic diabetes insipidus (HP:0009806)3.80962050
2Gait imbalance (HP:0002141)3.80532940
3Congenital primary aphakia (HP:0007707)3.73739543
4Medial flaring of the eyebrow (HP:0010747)3.57718838
5Cortical dysplasia (HP:0002539)3.44330584
6True hermaphroditism (HP:0010459)3.31677917
7Pancreatic fibrosis (HP:0100732)3.05276787
8Chronic hepatic failure (HP:0100626)3.00642568
9Vaginal atresia (HP:0000148)2.97478287
10Nephronophthisis (HP:0000090)2.96225926
11Genital tract atresia (HP:0001827)2.92181575
12Occipital encephalocele (HP:0002085)2.90358329
13Pancreatic cysts (HP:0001737)2.87197614
14Abnormality of the labia minora (HP:0012880)2.83762159
15Drooling (HP:0002307)2.71823306
16Poor coordination (HP:0002370)2.69552998
17Abnormality of the renal medulla (HP:0100957)2.57937694
18Abnormality of midbrain morphology (HP:0002418)2.55641824
19Molar tooth sign on MRI (HP:0002419)2.55641824
20Decreased testicular size (HP:0008734)2.46949233
21Lissencephaly (HP:0001339)2.46400386
22Retinal dysplasia (HP:0007973)2.39261251
23Excessive salivation (HP:0003781)2.37651790
24Aplasia/Hypoplasia of the tongue (HP:0010295)2.31241127
25Failure to thrive in infancy (HP:0001531)2.28991224
26Postaxial hand polydactyly (HP:0001162)2.26965875
27Broad foot (HP:0001769)2.26373399
28Specific learning disability (HP:0001328)2.21486488
29Papillary thyroid carcinoma (HP:0002895)2.19862061
30Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.17935140
31Abnormality of alanine metabolism (HP:0010916)2.17935140
32Hyperalaninemia (HP:0003348)2.17935140
33Hip dysplasia (HP:0001385)2.17290727
34Hyperventilation (HP:0002883)2.15511914
35Postaxial foot polydactyly (HP:0001830)2.14596668
36Renal dysplasia (HP:0000110)2.11750590
37Aplasia/Hypoplasia of the lens (HP:0008063)2.11355533
38Optic nerve hypoplasia (HP:0000609)2.10657450
39Absent speech (HP:0001344)2.09552378
40Pachygyria (HP:0001302)2.08827137
41Polyphagia (HP:0002591)2.07237666
42Focal motor seizures (HP:0011153)2.07175169
43Type II lissencephaly (HP:0007260)2.06456861
44Astigmatism (HP:0000483)2.06098116
45Polymicrogyria (HP:0002126)2.00340781
46Tubulointerstitial nephritis (HP:0001970)1.98323024
47Short foot (HP:0001773)1.96824873
48Hypsarrhythmia (HP:0002521)1.94108443
49Septo-optic dysplasia (HP:0100842)1.92585105
50Pheochromocytoma (HP:0002666)1.90807995
51Generalized myoclonic seizures (HP:0002123)1.90766988
52Methylmalonic acidemia (HP:0002912)1.87882480
53Micropenis (HP:0000054)1.87506961
54EEG with generalized epileptiform discharges (HP:0011198)1.87478512
55Follicular hyperkeratosis (HP:0007502)1.86986910
56Abnormality of the metopic suture (HP:0005556)1.86564974
57Cerebellar dysplasia (HP:0007033)1.86480609
58Abnormality of the renal cortex (HP:0011035)1.85696671
59Thyroid carcinoma (HP:0002890)1.85661701
60Abnormal respiratory motile cilium morphology (HP:0005938)1.85358703
61Abnormal respiratory epithelium morphology (HP:0012253)1.85358703
62Anencephaly (HP:0002323)1.85233796
63Epileptiform EEG discharges (HP:0011182)1.83996855
64Bile duct proliferation (HP:0001408)1.83432480
65Abnormal biliary tract physiology (HP:0012439)1.83432480
66Inability to walk (HP:0002540)1.80949868
67Sclerocornea (HP:0000647)1.80715342
68Volvulus (HP:0002580)1.80537323
69Abnormal ciliary motility (HP:0012262)1.79425614
70Muscular hypotonia of the trunk (HP:0008936)1.78917554
71Left ventricular hypertrophy (HP:0001712)1.78868481
72Narrow forehead (HP:0000341)1.78800443
73Hyperglycinemia (HP:0002154)1.77453285
74Progressive inability to walk (HP:0002505)1.76196792
75Exercise-induced muscle cramps (HP:0003710)1.75960815
76Preaxial hand polydactyly (HP:0001177)1.75518280
77Long foot (HP:0001833)1.75285251
78Amyotrophic lateral sclerosis (HP:0007354)1.75273281
79Aganglionic megacolon (HP:0002251)1.74324939
80Adrenal hypoplasia (HP:0000835)1.74300318
81Renal cortical cysts (HP:0000803)1.74268847
82Spastic tetraplegia (HP:0002510)1.72641397
83Small hand (HP:0200055)1.72319483
84Prominent nasal bridge (HP:0000426)1.70742969
85Colon cancer (HP:0003003)1.69710746
86Cystic liver disease (HP:0006706)1.69222901
87Intestinal atresia (HP:0011100)1.68740456
88Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.68215895
89Neuroendocrine neoplasm (HP:0100634)1.65950244
90Congenital hepatic fibrosis (HP:0002612)1.65488137
91Anterior segment dysgenesis (HP:0007700)1.64073008
92Supernumerary spleens (HP:0009799)1.61967690
93Abnormality of the lower motor neuron (HP:0002366)1.61575296
94Oligodactyly (hands) (HP:0001180)1.61548284
95Decreased muscle mass (HP:0003199)1.60886136
96Exotropia (HP:0000577)1.60588176
97Dandy-Walker malformation (HP:0001305)1.60087562
98Aplasia/Hypoplasia of the brainstem (HP:0007362)1.60066597
99Hypoplasia of the brainstem (HP:0002365)1.60066597
100Broad-based gait (HP:0002136)1.60055790

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.70009242
2BCR3.61806946
3TRIM283.33632716
4MARK12.98404653
5MAP3K42.92771829
6CASK2.76535718
7TIE12.74272551
8MAP2K72.60456518
9SRPK12.14084645
10EPHA42.09455981
11WNK32.05641721
12ERBB32.05394202
13MINK11.91682331
14MAPK131.91115317
15CSNK1G11.90248417
16CSNK1G31.90186846
17CSNK1G21.87005416
18DYRK21.85111842
19CSNK1A1L1.77380680
20STK38L1.71942745
21CLK11.60453738
22FRK1.50933994
23EPHB21.48249623
24PAK31.42876433
25PLK21.42666216
26MKNK21.34210048
27PINK11.25377385
28PBK1.24317884
29RPS6KA41.20361803
30NUAK11.20184265
31BCKDK1.19998721
32MKNK11.11642243
33FER1.11120905
34DYRK31.06004776
35BUB11.04998473
36BMPR1B1.04729768
37PLK31.01829089
38PNCK0.99251127
39NTRK20.99048269
40SIK30.95365120
41AKT30.93049823
42LIMK10.91292062
43LATS10.88171834
44MAP2K40.87903870
45CDC70.85395746
46CDK30.83754556
47KSR10.81365933
48GRK10.79960426
49PRKCE0.79082323
50NEK10.77845715
51PRKCG0.73741005
52PAK60.72058846
53UHMK10.71817551
54MAP3K60.71052243
55CDK140.69204158
56OBSCN0.67431662
57TNIK0.65609326
58WEE10.65392314
59CDK180.63978084
60ERBB40.63664848
61CAMK2A0.63154889
62PIM20.60842394
63BRSK20.60036104
64PKN10.59611165
65FGFR20.58131799
66ATR0.56935822
67CAMK2B0.56182185
68SGK2230.55854542
69SGK4940.55854542
70PLK10.54626071
71CDK50.54206074
72INSRR0.54148481
73CSNK1A10.53525761
74CDK150.52162980
75BRD40.52100109
76VRK10.52092030
77YES10.50457752
78PHKG20.50167563
79PHKG10.50167563
80ADRBK20.48396050
81TTK0.47014093
82NTRK30.46976323
83CDK11A0.44070748
84DYRK1B0.43721599
85DYRK1A0.41781346
86CSNK1D0.40037828
87CAMK40.39910670
88CSNK1E0.39537408
89ROCK10.39200290
90ATM0.37696498
91SGK20.37447068
92CCNB10.37287150
93PRKAA10.37096928
94CAMK2G0.37035074
95TAF10.36985885
96PRKACB0.34635633
97OXSR10.34376678
98PRKACA0.34341959
99RAF10.32975419
100FGFR10.32941759

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.01747636
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.87615175
3Nicotine addiction_Homo sapiens_hsa050332.86437973
4Steroid biosynthesis_Homo sapiens_hsa001002.71981034
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.61994911
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.40008806
7Basal transcription factors_Homo sapiens_hsa030222.37610400
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.22087078
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.03031893
10Propanoate metabolism_Homo sapiens_hsa006401.70236209
11Butanoate metabolism_Homo sapiens_hsa006501.64817760
12Phototransduction_Homo sapiens_hsa047441.61613875
13Fanconi anemia pathway_Homo sapiens_hsa034601.58301682
14GABAergic synapse_Homo sapiens_hsa047271.51200417
15Regulation of autophagy_Homo sapiens_hsa041401.46775311
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.36636950
17Synaptic vesicle cycle_Homo sapiens_hsa047211.35782155
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35709481
19Axon guidance_Homo sapiens_hsa043601.33258660
20Dopaminergic synapse_Homo sapiens_hsa047281.31983888
21Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.25631267
22Hippo signaling pathway_Homo sapiens_hsa043901.22246785
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15067029
24Selenocompound metabolism_Homo sapiens_hsa004501.13799978
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13375994
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12946914
27Oxidative phosphorylation_Homo sapiens_hsa001901.10827082
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.07964161
29RNA polymerase_Homo sapiens_hsa030201.07097306
30Cocaine addiction_Homo sapiens_hsa050301.06261191
31Taste transduction_Homo sapiens_hsa047421.05957222
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05562064
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01905931
34Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.01591703
35Oocyte meiosis_Homo sapiens_hsa041141.00097085
36Basal cell carcinoma_Homo sapiens_hsa052170.99736988
37Collecting duct acid secretion_Homo sapiens_hsa049660.99135402
38Non-homologous end-joining_Homo sapiens_hsa034500.98476528
39Morphine addiction_Homo sapiens_hsa050320.96017199
40Glutamatergic synapse_Homo sapiens_hsa047240.95296874
41Fatty acid biosynthesis_Homo sapiens_hsa000610.94439018
42Hedgehog signaling pathway_Homo sapiens_hsa043400.93726760
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90463245
44Proteasome_Homo sapiens_hsa030500.89393856
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89185356
46RNA degradation_Homo sapiens_hsa030180.87697008
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85431569
48Vibrio cholerae infection_Homo sapiens_hsa051100.85099649
49Huntingtons disease_Homo sapiens_hsa050160.84169821
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83809993
51RNA transport_Homo sapiens_hsa030130.82404660
52TGF-beta signaling pathway_Homo sapiens_hsa043500.81469849
53Amphetamine addiction_Homo sapiens_hsa050310.77097220
54Parkinsons disease_Homo sapiens_hsa050120.76387327
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75842883
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75437183
57Fatty acid metabolism_Homo sapiens_hsa012120.72459421
58Circadian entrainment_Homo sapiens_hsa047130.72439839
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.72373716
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71182831
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69719459
62Circadian rhythm_Homo sapiens_hsa047100.69172654
63Ether lipid metabolism_Homo sapiens_hsa005650.68283115
64Cell cycle_Homo sapiens_hsa041100.67644744
65Vitamin B6 metabolism_Homo sapiens_hsa007500.67453671
66Insulin secretion_Homo sapiens_hsa049110.65059796
67Serotonergic synapse_Homo sapiens_hsa047260.64994968
68Cardiac muscle contraction_Homo sapiens_hsa042600.64704803
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63383614
70Olfactory transduction_Homo sapiens_hsa047400.63370491
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63189178
72Tight junction_Homo sapiens_hsa045300.62970043
73Arginine and proline metabolism_Homo sapiens_hsa003300.62610550
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61838561
75Fatty acid elongation_Homo sapiens_hsa000620.61668171
76Spliceosome_Homo sapiens_hsa030400.59578804
77Wnt signaling pathway_Homo sapiens_hsa043100.56598967
78Metabolic pathways_Homo sapiens_hsa011000.56029051
79ABC transporters_Homo sapiens_hsa020100.52848352
80Peroxisome_Homo sapiens_hsa041460.52635561
81Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52219464
82mRNA surveillance pathway_Homo sapiens_hsa030150.51924625
83Homologous recombination_Homo sapiens_hsa034400.51889671
84Nucleotide excision repair_Homo sapiens_hsa034200.50744913
85beta-Alanine metabolism_Homo sapiens_hsa004100.50690184
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.49369485
87N-Glycan biosynthesis_Homo sapiens_hsa005100.47862696
88Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47034173
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.46828425
90Folate biosynthesis_Homo sapiens_hsa007900.46000292
91Pyruvate metabolism_Homo sapiens_hsa006200.45899352
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44080196
93AMPK signaling pathway_Homo sapiens_hsa041520.43686525
94Mismatch repair_Homo sapiens_hsa034300.43581185
95Tryptophan metabolism_Homo sapiens_hsa003800.43285579
96Alzheimers disease_Homo sapiens_hsa050100.43081871
97Sulfur metabolism_Homo sapiens_hsa009200.42410701
98Melanoma_Homo sapiens_hsa052180.42360143
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41291424
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.40959517

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