ZMYND19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ZMYND19 is a MYND zinc finger domain-containing protein that binds to the C terminus of melanin-concentrating hormone receptor-1 (MCHR1; MIM 601751) (Bachner et al., 2002 [PubMed 12208518]), and to the N termini of alpha-tubulin (TUBA1; MIM 191110), and beta-tubulin (TUBB; MIM 191130) (Francke et al., 2005 [PubMed 16039987]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)5.98036503
2DNA unwinding involved in DNA replication (GO:0006268)4.97281558
3nuclear pore organization (GO:0006999)4.74251352
4DNA replication initiation (GO:0006270)4.65437317
5nuclear pore complex assembly (GO:0051292)4.64688043
6protein localization to kinetochore (GO:0034501)4.64009049
7folic acid-containing compound biosynthetic process (GO:0009396)4.47791528
8mitotic nuclear envelope disassembly (GO:0007077)4.38035961
9mitotic metaphase plate congression (GO:0007080)4.28828068
10DNA replication checkpoint (GO:0000076)4.23954781
11DNA replication-dependent nucleosome assembly (GO:0006335)4.23521562
12DNA replication-dependent nucleosome organization (GO:0034723)4.23521562
13DNA strand elongation involved in DNA replication (GO:0006271)4.20909489
14protein localization to chromosome, centromeric region (GO:0071459)4.18094257
15nuclear envelope disassembly (GO:0051081)4.12425412
16membrane disassembly (GO:0030397)4.12425412
17regulation of mammary gland epithelial cell proliferation (GO:0033599)4.11009569
18nucleobase biosynthetic process (GO:0046112)4.05936955
19mitotic chromosome condensation (GO:0007076)4.02284217
20regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.01333823
21DNA strand elongation (GO:0022616)3.97396381
22ribosomal small subunit assembly (GO:0000028)3.95889953
23IMP biosynthetic process (GO:0006188)3.92247177
24pre-miRNA processing (GO:0031054)3.87600948
25translational elongation (GO:0006414)3.86209603
26formation of translation preinitiation complex (GO:0001731)3.80585734
27mitotic sister chromatid segregation (GO:0000070)3.79823119
28heterochromatin organization (GO:0070828)3.79080382
29regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.72652380
30ribosome assembly (GO:0042255)3.71777089
31ribosome biogenesis (GO:0042254)3.71764641
32proline biosynthetic process (GO:0006561)3.71408790
33mitotic sister chromatid cohesion (GO:0007064)3.70284910
34maturation of SSU-rRNA (GO:0030490)3.69597493
35purine nucleobase biosynthetic process (GO:0009113)3.67226888
36telomere maintenance via semi-conservative replication (GO:0032201)3.65826495
37metaphase plate congression (GO:0051310)3.65783851
38DNA duplex unwinding (GO:0032508)3.59723151
39DNA geometric change (GO:0032392)3.57640504
40sister chromatid segregation (GO:0000819)3.57262343
41positive regulation of chromosome segregation (GO:0051984)3.56565616
42IMP metabolic process (GO:0046040)3.53793694
43SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.51633344
44nucleobase-containing small molecule interconversion (GO:0015949)3.48367040
45viral life cycle (GO:0019058)3.47346515
46cellular protein complex localization (GO:0034629)3.44920398
47histone H2A monoubiquitination (GO:0035518)3.44853811
48protein targeting to ER (GO:0045047)3.44239191
49cotranslational protein targeting to membrane (GO:0006613)3.42004097
50negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.40949689
51pore complex assembly (GO:0046931)3.40454226
52spliceosomal tri-snRNP complex assembly (GO:0000244)3.40385364
53protein K6-linked ubiquitination (GO:0085020)3.39119207
54cellular protein complex disassembly (GO:0043624)3.38971523
55rRNA transcription (GO:0009303)3.36706058
56chromatin assembly or disassembly (GO:0006333)3.35861771
57ribonucleoprotein complex biogenesis (GO:0022613)3.34492081
58viral mRNA export from host cell nucleus (GO:0046784)3.34141568
59nuclear envelope organization (GO:0006998)3.32848244
60regulation of spindle organization (GO:0090224)3.32588219
61protein complex disassembly (GO:0043241)3.30293677
62establishment of protein localization to endoplasmic reticulum (GO:0072599)3.29605807
63ribosomal large subunit biogenesis (GO:0042273)3.28459301
64peptidyl-arginine omega-N-methylation (GO:0035247)3.28334799
65regulation of histone H3-K9 methylation (GO:0051570)3.27797100
66DNA replication-independent nucleosome organization (GO:0034724)3.27750969
67DNA replication-independent nucleosome assembly (GO:0006336)3.27750969
68regulation of RNA export from nucleus (GO:0046831)3.27587506
69negative regulation of histone methylation (GO:0031061)3.27418518
70chromatin remodeling at centromere (GO:0031055)3.25164255
71telomere maintenance via recombination (GO:0000722)3.24837778
72regulation of sister chromatid cohesion (GO:0007063)3.23320849
73chromatin assembly (GO:0031497)3.22298414
74translational initiation (GO:0006413)3.21692403
75regulation of chromosome segregation (GO:0051983)3.21682144
76protein localization to chromosome (GO:0034502)3.21231553
77protein localization to endoplasmic reticulum (GO:0070972)3.20056504
78mitotic recombination (GO:0006312)3.19537175
79rRNA processing (GO:0006364)3.17443401
80translational termination (GO:0006415)3.16501844
81histone arginine methylation (GO:0034969)3.16180827
82protein maturation by protein folding (GO:0022417)3.15231076
83monoubiquitinated protein deubiquitination (GO:0035520)3.14905567
84establishment of chromosome localization (GO:0051303)3.14581973
85viral transcription (GO:0019083)3.14213019
86L-serine metabolic process (GO:0006563)3.13163113
87negative regulation of RNA splicing (GO:0033119)3.13106552
88spliceosomal snRNP assembly (GO:0000387)3.13029655
89regulation of translational termination (GO:0006449)3.11733115
90regulation of gene silencing by RNA (GO:0060966)3.11226428
91regulation of posttranscriptional gene silencing (GO:0060147)3.11226428
92regulation of gene silencing by miRNA (GO:0060964)3.11226428
93rRNA metabolic process (GO:0016072)3.10513726
94negative regulation of mRNA metabolic process (GO:1903312)3.10286631
95attachment of spindle microtubules to kinetochore (GO:0008608)3.10048957
96CENP-A containing nucleosome assembly (GO:0034080)3.09931802
97DNA deamination (GO:0045006)3.07784149
98macromolecular complex disassembly (GO:0032984)3.07182243
99histone exchange (GO:0043486)3.06735060
100DNA conformation change (GO:0071103)3.05933846
101negative regulation of chromosome segregation (GO:0051985)3.04566291
102somatic diversification of immune receptors via somatic mutation (GO:0002566)3.03086863
103somatic hypermutation of immunoglobulin genes (GO:0016446)3.03086863
104nucleosome disassembly (GO:0006337)3.01963310
105protein-DNA complex disassembly (GO:0032986)3.01963310
106positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.01747718
107nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.01548026
108nucleotide-excision repair, DNA gap filling (GO:0006297)3.00348338
109telomere maintenance via telomere lengthening (GO:0010833)2.99748496
110negative regulation of mRNA processing (GO:0050686)2.99071383
111spindle checkpoint (GO:0031577)2.98413246
112translesion synthesis (GO:0019985)2.98267119
113deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.98205686
114regulation of translational fidelity (GO:0006450)2.97953787
115kinetochore organization (GO:0051383)2.97882550
116chromosome condensation (GO:0030261)2.96777135
117maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.96604233
118peptidyl-arginine methylation (GO:0018216)2.96496718
119peptidyl-arginine N-methylation (GO:0035246)2.96496718
120dosage compensation (GO:0007549)2.95850544
121ATP-dependent chromatin remodeling (GO:0043044)2.95338128
122folic acid metabolic process (GO:0046655)2.95332149
123gene silencing by RNA (GO:0031047)2.94852102
124protein complex localization (GO:0031503)2.94018390
125negative regulation of mitotic sister chromatid separation (GO:2000816)2.93660016
126negative regulation of mitotic sister chromatid segregation (GO:0033048)2.93660016
127negative regulation of sister chromatid segregation (GO:0033046)2.93660016
128apoptotic process involved in morphogenesis (GO:0060561)2.93200290
129pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.92314696
130planar cell polarity pathway involved in neural tube closure (GO:0090179)2.87668709
131DNA topological change (GO:0006265)2.84436427
132pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.76941938
133pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.76518245
134protein export from nucleus (GO:0006611)2.74228282
135regulation of mitochondrial translation (GO:0070129)2.72581280
136establishment of integrated proviral latency (GO:0075713)2.71266634
137negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.70628626
138regulation of translational elongation (GO:0006448)2.70589273
139cellular component biogenesis (GO:0044085)2.66626978
140nuclear envelope reassembly (GO:0031468)2.63911706
141mitotic nuclear envelope reassembly (GO:0007084)2.63911706
142protein targeting to membrane (GO:0006612)2.63866377
143protein retention in ER lumen (GO:0006621)2.63058042
144regulation of chromatin binding (GO:0035561)2.62894625
145translation (GO:0006412)2.62813592
146mRNA stabilization (GO:0048255)2.62223589
147RNA stabilization (GO:0043489)2.62223589
148positive regulation of DNA-dependent DNA replication (GO:2000105)2.59289371
149DNA synthesis involved in DNA repair (GO:0000731)2.58941115

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.32204199
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.74076572
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.28700484
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.75595147
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.43037645
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.29073302
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.17975489
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.75208705
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.70783215
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.56321728
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.44644093
12MYC_22102868_ChIP-Seq_BL_Human2.34751498
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.26429722
14XRN2_22483619_ChIP-Seq_HELA_Human2.25820311
15AR_21909140_ChIP-Seq_LNCAP_Human2.22027759
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.17999838
17* E2F1_21310950_ChIP-Seq_MCF-7_Human2.17093481
18KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.16732765
19* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16371988
20* MYCN_18555785_ChIP-Seq_MESCs_Mouse2.08908195
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.07337556
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.07336639
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.98043151
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.94383951
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.92952683
26POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.84804503
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.83708930
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.83452009
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.82703173
30GABP_17652178_ChIP-ChIP_JURKAT_Human1.82256082
31VDR_23849224_ChIP-Seq_CD4+_Human1.80335883
32GABP_19822575_ChIP-Seq_HepG2_Human1.76951828
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76051482
34LXR_22292898_ChIP-Seq_THP-1_Human1.75707451
35KDM5A_27292631_Chip-Seq_BREAST_Human1.74036745
36TTF2_22483619_ChIP-Seq_HELA_Human1.73179445
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68268179
38* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.68206393
39FOXP3_21729870_ChIP-Seq_TREG_Human1.67614960
40CIITA_25753668_ChIP-Seq_RAJI_Human1.66909892
41SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.65404687
42DCP1A_22483619_ChIP-Seq_HELA_Human1.63493842
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.62922076
44E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60510517
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59617750
46* RACK7_27058665_Chip-Seq_MCF-7_Human1.59486819
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.55108375
48KLF4_18555785_ChIP-Seq_MESCs_Mouse1.54583566
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.54085918
50* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.53079894
51PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.48319639
52TET1_21451524_ChIP-Seq_MESCs_Mouse1.47761175
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46837844
54* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.45881959
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44989837
56CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.40000718
57STAT3_1855785_ChIP-Seq_MESCs_Mouse1.38599157
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33911394
59SRY_22984422_ChIP-ChIP_TESTIS_Rat1.32098641
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.31898953
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.30089528
62ZNF263_19887448_ChIP-Seq_K562_Human1.30082151
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29645299
64P68_20966046_ChIP-Seq_HELA_Human1.26249742
65E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.25394546
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25297331
67CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.24810755
68VDR_21846776_ChIP-Seq_THP-1_Human1.24413444
69RBPJ_22232070_ChIP-Seq_NCS_Mouse1.23979406
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23283046
71ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20742946
72NANOG_21062744_ChIP-ChIP_HESCs_Human1.20101015
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19500681
74SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.18288571
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17706001
76NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16818233
77* KDM2B_26808549_Chip-Seq_DND41_Human1.16618437
78YY1_21170310_ChIP-Seq_MESCs_Mouse1.15445367
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15205991
80SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14908359
81SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.13910664
82RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13309294
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13102091
84ERG_21242973_ChIP-ChIP_JURKAT_Human1.12553588
85TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12455266
86HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.12161378
87CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12028540
88NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.11747636
89* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10130198
90UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10031536
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09803164
92SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.09631853
93KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09596574
94TFEB_21752829_ChIP-Seq_HELA_Human1.08798183
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08382579
96KDM2B_26808549_Chip-Seq_K562_Human1.07417967
97SA1_27219007_Chip-Seq_ERYTHROID_Human1.07324955
98NOTCH1_21737748_ChIP-Seq_TLL_Human1.07233908
99KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06276690
100NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.06233727
101* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05154525
102HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04947986
103* FOXP1_21924763_ChIP-Seq_HESCs_Human1.04770806
104KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04177694
105KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03269345
106CTCF_18555785_ChIP-Seq_MESCs_Mouse1.03185714
107DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03117453
108HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03113802
109NCOR1_26117541_ChIP-Seq_K562_Human1.00929157
110ELK1_19687146_ChIP-ChIP_HELA_Human1.00164517
111CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99957953
112* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99817339
113P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97317375
114CREB1_26743006_Chip-Seq_LNCaP_Human0.96690388
115SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.95657211
116OCT4_18692474_ChIP-Seq_MEFs_Mouse0.95140842
117MYC_18940864_ChIP-ChIP_HL60_Human0.93288664
118KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.91552860
119KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.91552860
120KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.91552860
121NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.91011946
122ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89795830
123TCF7_22412390_ChIP-Seq_EML_Mouse0.89428780
124PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89163470
125ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88472943
126CHD1_26751641_Chip-Seq_LNCaP_Human0.88413660
127BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87759812
128* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87742303
129TCF3_18692474_ChIP-Seq_MEFs_Mouse0.87659158
130TCF3_18692474_ChIP-Seq_MESCs_Mouse0.83685382
131ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.83113599
132KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.80464188
133NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.78689144
134ATF3_27146783_Chip-Seq_COLON_Human0.78587655
135GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.78444238

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.79310340
2MP0003111_abnormal_nucleus_morphology4.70451148
3MP0010094_abnormal_chromosome_stability4.60592636
4MP0004957_abnormal_blastocyst_morpholog4.25159569
5MP0003077_abnormal_cell_cycle3.89627092
6MP0008057_abnormal_DNA_replication3.89173211
7MP0003123_paternal_imprinting2.86131931
8MP0008058_abnormal_DNA_repair2.75657549
9MP0001730_embryonic_growth_arrest2.74764134
10MP0008877_abnormal_DNA_methylation2.61607612
11MP0008007_abnormal_cellular_replicative2.56405235
12MP0000350_abnormal_cell_proliferation2.55550643
13MP0010352_gastrointestinal_tract_polyps2.51749271
14MP0005623_abnormal_meninges_morphology2.46322155
15MP0008932_abnormal_embryonic_tissue2.42832026
16MP0009379_abnormal_foot_pigmentation2.40419270
17MP0010307_abnormal_tumor_latency2.22453320
18MP0001672_abnormal_embryogenesis/_devel2.16336265
19MP0005380_embryogenesis_phenotype2.16336265
20MP0005451_abnormal_body_composition2.15198298
21MP0002396_abnormal_hematopoietic_system2.13034765
22MP0001697_abnormal_embryo_size2.05525965
23MP0000678_abnormal_parathyroid_gland2.01209490
24MP0002084_abnormal_developmental_patter1.99110127
25MP0002085_abnormal_embryonic_tissue1.98463505
26MP0005076_abnormal_cell_differentiation1.95571227
27MP0003984_embryonic_growth_retardation1.93990476
28MP0004858_abnormal_nervous_system1.91402794
29MP0002088_abnormal_embryonic_growth/wei1.89958016
30MP0005501_abnormal_skin_physiology1.89701235
31MP0001346_abnormal_lacrimal_gland1.89427594
32MP0002249_abnormal_larynx_morphology1.88940282
33MP0002080_prenatal_lethality1.83484806
34MP0003890_abnormal_embryonic-extraembry1.82083598
35MP0002653_abnormal_ependyma_morphology1.81230756
36MP0004197_abnormal_fetal_growth/weight/1.78984125
37MP0002086_abnormal_extraembryonic_tissu1.75099682
38MP0002163_abnormal_gland_morphology1.68108331
39MP0000490_abnormal_crypts_of1.67915736
40MP0002796_impaired_skin_barrier1.67851102
41MP0003786_premature_aging1.63534907
42MP0000537_abnormal_urethra_morphology1.63030441
43MP0002210_abnormal_sex_determination1.61776486
44MP0001348_abnormal_lacrimal_gland1.61701450
45MP0003718_maternal_effect1.58559785
46MP0003705_abnormal_hypodermis_morpholog1.53922656
47MP0003121_genomic_imprinting1.49587907
48MP0001929_abnormal_gametogenesis1.47663835
49MP0004808_abnormal_hematopoietic_stem1.46566922
50MP0003119_abnormal_digestive_system1.43905510
51MP0001145_abnormal_male_reproductive1.43599410
52MP0000313_abnormal_cell_death1.42093809
53MP0003567_abnormal_fetal_cardiomyocyte1.41071534
54MP0002019_abnormal_tumor_incidence1.38338168
55MP0003453_abnormal_keratinocyte_physiol1.35114836
56MP0009672_abnormal_birth_weight1.30892943
57MP0003942_abnormal_urinary_system1.28007638
58MP0000653_abnormal_sex_gland1.26336269
59MP0009278_abnormal_bone_marrow1.24093695
60MP0000579_abnormal_nail_morphology1.23195022
61MP0001293_anophthalmia1.22547839
62MP0005397_hematopoietic_system_phenotyp1.21748435
63MP0001545_abnormal_hematopoietic_system1.21748435
64MP0008260_abnormal_autophagy1.21594246
65MP0000049_abnormal_middle_ear1.20781096
66MP0009053_abnormal_anal_canal1.20338104
67MP0003315_abnormal_perineum_morphology1.19466883
68MP0002877_abnormal_melanocyte_morpholog1.18716400
69MP0000003_abnormal_adipose_tissue1.16320756
70MP0001661_extended_life_span1.13227283
71MP0003221_abnormal_cardiomyocyte_apopto1.12542135
72MP0010030_abnormal_orbit_morphology1.12315677
73MP0002089_abnormal_postnatal_growth/wei1.09590281
74MP0005666_abnormal_adipose_tissue1.07665910
75MP0003937_abnormal_limbs/digits/tail_de1.05941280
76MP0009703_decreased_birth_body1.05560547
77MP0000762_abnormal_tongue_morphology1.05109136
78MP0001849_ear_inflammation1.05059055
79MP0003566_abnormal_cell_adhesion1.02211699
80MP0000703_abnormal_thymus_morphology1.01619670
81MP0000428_abnormal_craniofacial_morphol0.99535194
82MP0000566_synostosis0.98514932
83MP0001188_hyperpigmentation0.94193517
84MP0002234_abnormal_pharynx_morphology0.93839886
85MP0003385_abnormal_body_wall0.93726234
86MP0005409_darkened_coat_color0.93476783
87MP0003698_abnormal_male_reproductive0.91320750
88MP0005375_adipose_tissue_phenotype0.91046971
89MP0006292_abnormal_olfactory_placode0.90689716
90MP0003861_abnormal_nervous_system0.90051566
91MP0003941_abnormal_skin_development0.89852119
92MP0004264_abnormal_extraembryonic_tissu0.88299079
93MP0002098_abnormal_vibrissa_morphology0.88064771
94MP0002060_abnormal_skin_morphology0.87600023
95MP0005257_abnormal_intraocular_pressure0.87414564
96MP0009333_abnormal_splenocyte_physiolog0.87293150
97MP0002111_abnormal_tail_morphology0.86981506
98MP0004185_abnormal_adipocyte_glucose0.86455566
99MP0006035_abnormal_mitochondrial_morpho0.85207420
100MP0001915_intracranial_hemorrhage0.84792548
101MP0001216_abnormal_epidermal_layer0.82754541
102MP0002092_abnormal_eye_morphology0.82694926
103MP0002102_abnormal_ear_morphology0.82672734
104MP0002161_abnormal_fertility/fecundity0.82665661
105MP0008770_decreased_survivor_rate0.82655334
106MP0009250_abnormal_appendicular_skeleto0.82468686
107MP0003935_abnormal_craniofacial_develop0.80485042
108MP0001119_abnormal_female_reproductive0.80288531
109MP0001881_abnormal_mammary_gland0.79917596
110MP0005621_abnormal_cell_physiology0.79834335
111MP0005384_cellular_phenotype0.79815380
112MP0003699_abnormal_female_reproductive0.78485502
113MP0004233_abnormal_muscle_weight0.77804078
114MP0000733_abnormal_muscle_development0.77422751
115MP0003763_abnormal_thymus_physiology0.76658991
116MP0000358_abnormal_cell_content/0.75845735
117MP0005187_abnormal_penis_morphology0.75109533
118MP0003115_abnormal_respiratory_system0.74841523
119MP0002116_abnormal_craniofacial_bone0.74131530
120MP0005058_abnormal_lysosome_morphology0.73725338
121MP0000432_abnormal_head_morphology0.73085154
122MP0002398_abnormal_bone_marrow0.72877365
123MP0010630_abnormal_cardiac_muscle0.71144354
124MP0000477_abnormal_intestine_morphology0.70036800
125MP0001286_abnormal_eye_development0.70019178
126MP0000534_abnormal_ureter_morphology0.69821722
127MP0002697_abnormal_eye_size0.69224725
128MP0002160_abnormal_reproductive_system0.68349972
129MP0008995_early_reproductive_senescence0.67558336
130MP0002722_abnormal_immune_system0.67128073
131MP0000627_abnormal_mammary_gland0.67105827
132MP0005389_reproductive_system_phenotype0.62703216
133MP0002075_abnormal_coat/hair_pigmentati0.61212159
134MP0002925_abnormal_cardiovascular_devel0.59940505
135MP0002114_abnormal_axial_skeleton0.59550406
136MP0010234_abnormal_vibrissa_follicle0.58745930
137MP0000689_abnormal_spleen_morphology0.58258430
138MP0003755_abnormal_palate_morphology0.58055597
139MP0000858_altered_metastatic_potential0.55103157
140MP0003938_abnormal_ear_development0.53988705
141MP0003646_muscle_fatigue0.51308592

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.42728219
2Ependymoma (HP:0002888)4.24114167
3Aplasia/Hypoplasia of the sacrum (HP:0008517)3.79856131
4Breast hypoplasia (HP:0003187)3.49012156
5Medulloblastoma (HP:0002885)3.47533272
6Selective tooth agenesis (HP:0001592)3.45060407
7Progressive muscle weakness (HP:0003323)3.44207563
8Broad distal phalanx of finger (HP:0009836)3.44104661
9Colon cancer (HP:0003003)3.34925853
10Chromsome breakage (HP:0040012)3.26832938
11Abnormality of cells of the erythroid lineage (HP:0012130)3.25126316
12Patellar aplasia (HP:0006443)3.20211923
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.18738780
14Facial hemangioma (HP:0000329)3.17340886
15Rhabdomyosarcoma (HP:0002859)3.15613925
16Astrocytoma (HP:0009592)3.12284162
17Abnormality of the astrocytes (HP:0100707)3.12284162
18Reticulocytopenia (HP:0001896)3.09351450
19Aplasia/Hypoplasia of the patella (HP:0006498)3.05636677
20Abnormal number of erythroid precursors (HP:0012131)3.01332166
21Impulsivity (HP:0100710)3.00210062
22Abnormality of the labia minora (HP:0012880)2.97888092
23Microvesicular hepatic steatosis (HP:0001414)2.93231964
24Insomnia (HP:0100785)2.89097346
25Abnormality of chromosome stability (HP:0003220)2.82960514
26Neoplasm of striated muscle (HP:0009728)2.82229000
27Basal cell carcinoma (HP:0002671)2.80938719
28Ulnar bowing (HP:0003031)2.80782826
29Abnormality of the anterior horn cell (HP:0006802)2.75852496
30Degeneration of anterior horn cells (HP:0002398)2.75852496
31Meckel diverticulum (HP:0002245)2.71807783
32Increased nuchal translucency (HP:0010880)2.71095124
33Absent thumb (HP:0009777)2.65401727
34Oral leukoplakia (HP:0002745)2.64118384
35Prominent nose (HP:0000448)2.62090721
36Abnormality of the ileum (HP:0001549)2.61895688
37Truncus arteriosus (HP:0001660)2.60815106
38Abnormality of the preputium (HP:0100587)2.60058334
39Achilles tendon contracture (HP:0001771)2.56687402
40Long palpebral fissure (HP:0000637)2.56661432
41Glioma (HP:0009733)2.56553941
42Neoplasm of the oral cavity (HP:0100649)2.54746239
43Septate vagina (HP:0001153)2.54712445
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.54510033
45Ragged-red muscle fibers (HP:0003200)2.52106540
46Myelodysplasia (HP:0002863)2.49980448
47Overlapping toe (HP:0001845)2.45896095
48Carpal bone hypoplasia (HP:0001498)2.44255490
49Abnormal number of incisors (HP:0011064)2.42117860
50Abnormality of the phalanges of the hallux (HP:0010057)2.41612335
51Multiple enchondromatosis (HP:0005701)2.41246076
52Hyperthyroidism (HP:0000836)2.39622567
53Atresia of the external auditory canal (HP:0000413)2.37580872
54Premature ovarian failure (HP:0008209)2.37308565
55Abnormality of the distal phalanges of the toes (HP:0010182)2.36822863
56Squamous cell carcinoma (HP:0002860)2.35427617
57Absent radius (HP:0003974)2.34096682
58Neoplasm of the pancreas (HP:0002894)2.33766236
59Deep palmar crease (HP:0006191)2.33016081
60Proximal placement of thumb (HP:0009623)2.33002535
61Cafe-au-lait spot (HP:0000957)2.31962041
62Elfin facies (HP:0004428)2.31749737
63Missing ribs (HP:0000921)2.31586172
64Abnormality of the carotid arteries (HP:0005344)2.31330189
65Deviation of the thumb (HP:0009603)2.31011098
66Hyperacusis (HP:0010780)2.28420425
67Cerebral hypomyelination (HP:0006808)2.27837570
68Patellar dislocation (HP:0002999)2.25700533
69Agnosia (HP:0010524)2.25611465
70Angiofibromas (HP:0010615)2.24094958
71Adenoma sebaceum (HP:0009720)2.24094958
72Abnormality of the umbilical cord (HP:0010881)2.24034155
73Aplasia involving forearm bones (HP:0009822)2.23194324
74Absent forearm bone (HP:0003953)2.23194324
75Asymmetry of the thorax (HP:0001555)2.22657099
76Volvulus (HP:0002580)2.22319248
77Duodenal stenosis (HP:0100867)2.18964464
78Small intestinal stenosis (HP:0012848)2.18964464
79Abnormality of the Achilles tendon (HP:0005109)2.18619938
80Abnormality of reticulocytes (HP:0004312)2.16322757
81Rough bone trabeculation (HP:0100670)2.16189470
8211 pairs of ribs (HP:0000878)2.16013108
83Biliary tract neoplasm (HP:0100574)2.15261322
84Premature graying of hair (HP:0002216)2.13819347
85Aplastic anemia (HP:0001915)2.13059397
86Pelvic girdle muscle weakness (HP:0003749)2.11661086
87Abnormality of the fetal cardiovascular system (HP:0010948)2.10304834
88Abnormal umbilical cord blood vessels (HP:0011403)2.10304834
89Single umbilical artery (HP:0001195)2.10304834
90High pitched voice (HP:0001620)2.10189990
91Ectopic kidney (HP:0000086)2.10131608
92Supernumerary spleens (HP:0009799)2.09998821
93Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.09649816
94Short 4th metacarpal (HP:0010044)2.09649816
95Horseshoe kidney (HP:0000085)2.09205916
96Tracheoesophageal fistula (HP:0002575)2.08873386
97Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.08670266
98High anterior hairline (HP:0009890)2.07996693
99Progressive external ophthalmoplegia (HP:0000590)2.07852379
100Renal duplication (HP:0000075)2.03776996
101Atrophy/Degeneration involving motor neurons (HP:0007373)2.03156012
102Abnormality of the lower motor neuron (HP:0002366)2.03047986
103Abnormal connection of the cardiac segments (HP:0011545)2.02403455
104Abnormal ventriculo-arterial connection (HP:0011563)2.02403455
105Transposition of the great arteries (HP:0001669)2.02403455
106Rib fusion (HP:0000902)2.02246389
107Macrocytic anemia (HP:0001972)2.01858135
108Pallor (HP:0000980)1.99899360
109Duplication of thumb phalanx (HP:0009942)1.99087276
110Heterotopia (HP:0002282)1.97581008
111Abnormality of the distal phalanx of the thumb (HP:0009617)1.97336641
112Sloping forehead (HP:0000340)1.96966342
113Premature rupture of membranes (HP:0001788)1.93451773
114Disproportionate tall stature (HP:0001519)1.93353283
115Short thumb (HP:0009778)1.91084824
116Abnormality of the tricuspid valve (HP:0001702)1.90213206
117Trismus (HP:0000211)1.89995748
118Bone marrow hypocellularity (HP:0005528)1.89762880
119Aplasia/hypoplasia of the humerus (HP:0006507)1.89327098
120Overriding aorta (HP:0002623)1.83572454
121Microretrognathia (HP:0000308)1.83141746
122Slender long bone (HP:0003100)1.83068483
123Shoulder girdle muscle weakness (HP:0003547)1.83031636
124Pointed chin (HP:0000307)1.83015673
125Secondary amenorrhea (HP:0000869)1.82645338
126Nonimmune hydrops fetalis (HP:0001790)1.82043873
127Abnormality of the calcaneus (HP:0008364)1.81103719
128Gastrointestinal carcinoma (HP:0002672)1.81083102
129Malignant gastrointestinal tract tumors (HP:0006749)1.81083102
130Fragile skin (HP:0001030)1.80612698
131Abnormality of cochlea (HP:0000375)1.80429808
132Vertebral compression fractures (HP:0002953)1.79369063
133Amaurosis fugax (HP:0100576)1.79182259
134Abnormality of the duodenum (HP:0002246)1.78548142
135Hypercalcemia (HP:0003072)1.78163338
136Renovascular hypertension (HP:0100817)1.77936796
137Abnormality of the aortic arch (HP:0012303)1.77621165
138Sparse lateral eyebrow (HP:0005338)1.77547069
139Spinal cord compression (HP:0002176)1.76795445
140Hyperparathyroidism (HP:0000843)1.76601879
141Male infertility (HP:0003251)1.76573607
142Turricephaly (HP:0000262)1.76231776
143Pseudobulbar signs (HP:0002200)1.76098190
144Testicular atrophy (HP:0000029)1.76044750
145Aplasia/Hypoplasia of the sternum (HP:0006714)1.75275947
146Congenital malformation of the right heart (HP:0011723)1.73292884
147Double outlet right ventricle (HP:0001719)1.73292884
148Intestinal polyp (HP:0005266)1.73215002
149Cutaneous melanoma (HP:0012056)1.72420986
150Premature skin wrinkling (HP:0100678)1.72046042
151Genu recurvatum (HP:0002816)1.71002222
152Rectal prolapse (HP:0002035)1.70561512
153Abnormality of glycolysis (HP:0004366)1.70235142
154Biconcave vertebral bodies (HP:0004586)1.70191436
155Ankyloglossia (HP:0010296)1.69800976
156Hypoparathyroidism (HP:0000829)1.67893103
157Unilateral renal agenesis (HP:0000122)1.66068173
158Spastic diplegia (HP:0001264)1.64917222
159Partial duplication of the phalanx of hand (HP:0009999)1.64886254
160Deviation of the hallux (HP:0010051)1.64460229
161Flat cornea (HP:0007720)1.61829846
162Shallow orbits (HP:0000586)1.60888691
163Partial duplication of thumb phalanx (HP:0009944)1.59461297
164Myopathic facies (HP:0002058)1.59420606
165Short middle phalanx of the 5th finger (HP:0004220)1.59203473
166Elbow flexion contracture (HP:0002987)1.57944161
167Arnold-Chiari malformation (HP:0002308)1.57472836
168Facial cleft (HP:0002006)1.56818739
169Abnormal large intestine physiology (HP:0012700)1.56000086
170Hallux valgus (HP:0001822)1.55989383

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.88666209
2SMG14.18739410
3WEE13.49729050
4NEK23.23453802
5CDK123.15817720
6EEF2K3.07721738
7IRAK32.97956543
8BUB12.61421676
9TTK2.57837362
10SRPK12.42006251
11MAP3K102.08617796
12VRK22.01951425
13PRPF4B2.01511101
14PKN21.99672722
15LATS21.97329309
16ACVR1B1.91686721
17PLK11.89079762
18SIK11.81138390
19CDK71.80276454
20CHEK21.77787585
21EIF2AK11.76459790
22NEK11.76268437
23CDK41.73615768
24TLK11.72887643
25MKNK11.67208760
26SCYL21.66652920
27ARAF1.66612519
28MKNK21.65905521
29DYRK31.63370945
30RPS6KB21.62983126
31TRIB31.60333740
32ATR1.60029596
33BRSK21.59995588
34TSSK61.51654638
35AURKB1.51619894
36LATS11.51282771
37MAP3K91.49836108
38ALK1.49796227
39MAP3K81.47984971
40NME21.45959274
41CHEK11.45382977
42PASK1.45381005
43BRAF1.41368407
44STK101.36348283
45MAP3K61.36309956
46STK31.29174597
47PLK31.24362544
48TAOK21.22336380
49BRSK11.18353325
50AURKA1.15497412
51TESK21.11713243
52CDK21.08761967
53RPS6KA41.08634403
54ATM1.05580820
55PLK41.05266267
56CAMK1D1.03342228
57STK161.03061845
58PIM20.99338289
59PBK0.99028263
60ICK0.95985425
61TGFBR10.94888861
62CDK60.93138092
63MTOR0.89910728
64CDK80.88736572
65TAF10.88387136
66MELK0.86961925
67PAK40.86950756
68TTN0.86847327
69IRAK20.86834076
70BRD40.81232549
71PDK30.81226455
72PDK40.81226455
73EPHA20.80614521
74MST1R0.79582264
75PNCK0.77447320
76CAMK1G0.76702802
77PIM10.75557618
78CDK10.73558662
79FLT30.72196393
80PTK20.71195893
81LRRK20.69762533
82PRKD30.69163434
83TYRO30.67984622
84NME10.66813494
85CSNK1E0.66033338
86TAOK10.64302357
87STK38L0.62905331
88CSNK2A20.62544783
89PAK10.59951870
90PAK20.59844158
91VRK10.59277417
92PTK60.58717494
93KDR0.57754590
94MAP3K130.57531635
95MAP3K50.54337504
96STK40.54059527
97MAP2K20.53960314
98CDK11A0.53955257
99AKT20.53094072
100ERN10.51951839
101CCNB10.50505533
102MAP2K30.49937934
103NTRK10.49871441
104CSNK1D0.49442022
105ABL20.49346268
106RAF10.48666418
107RPS6KL10.48298768
108RPS6KC10.48298768
109DYRK20.47371038
110ILK0.46658869
111CDK150.46360807
112CDK90.45990218
113PRKCI0.45340235
114PDPK10.44348165
115PRKDC0.43898893
116BMX0.43772678
117CSNK2A10.43574771
118FGFR40.43049980
119DMPK0.41618682
120RPS6KA10.40908104
121PDK20.40899741
122RPS6KA20.40606064
123ERBB40.40241689
124MAPKAPK30.40050214
125DAPK10.39917150
126GRK60.39026998
127MET0.38934898
128CDK180.38883324
129MAPK140.38367921
130CDK140.38025619
131MAP4K10.37488187
132EIF2AK30.35221957
133TESK10.34407742
134PDGFRA0.30829371
135MAPK110.30393278
136KSR20.29807076
137GSK3B0.29306150
138MAP3K110.28714351
139RPS6KB10.28536262
140AKT10.26244097

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.66510718
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.05253344
3Mismatch repair_Homo sapiens_hsa034303.81017103
4RNA transport_Homo sapiens_hsa030133.63832450
5Spliceosome_Homo sapiens_hsa030403.29059066
6Cell cycle_Homo sapiens_hsa041103.16438184
7RNA polymerase_Homo sapiens_hsa030202.91317741
8Base excision repair_Homo sapiens_hsa034102.89091726
9One carbon pool by folate_Homo sapiens_hsa006702.83073654
10Homologous recombination_Homo sapiens_hsa034402.74811066
11Ribosome_Homo sapiens_hsa030102.57096351
12Nucleotide excision repair_Homo sapiens_hsa034202.53470293
13mRNA surveillance pathway_Homo sapiens_hsa030152.42119078
14Fanconi anemia pathway_Homo sapiens_hsa034602.29310283
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.25421590
16Basal transcription factors_Homo sapiens_hsa030222.05481702
17Pyrimidine metabolism_Homo sapiens_hsa002402.04855452
18RNA degradation_Homo sapiens_hsa030181.92564674
19p53 signaling pathway_Homo sapiens_hsa041151.58717146
20Proteasome_Homo sapiens_hsa030501.49587956
21Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.46919418
22Non-homologous end-joining_Homo sapiens_hsa034501.44876470
23Oocyte meiosis_Homo sapiens_hsa041141.42627572
24Vitamin B6 metabolism_Homo sapiens_hsa007501.41332038
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.40470071
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.30971972
27Systemic lupus erythematosus_Homo sapiens_hsa053221.27239648
28Viral carcinogenesis_Homo sapiens_hsa052031.20267783
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17098575
30Epstein-Barr virus infection_Homo sapiens_hsa051691.10935173
31Thyroid cancer_Homo sapiens_hsa052161.08184421
32MicroRNAs in cancer_Homo sapiens_hsa052061.04023423
33Purine metabolism_Homo sapiens_hsa002301.03246563
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03001066
35mTOR signaling pathway_Homo sapiens_hsa041500.99305779
36Fructose and mannose metabolism_Homo sapiens_hsa000510.95240452
37HTLV-I infection_Homo sapiens_hsa051660.93947168
38Galactose metabolism_Homo sapiens_hsa000520.93376532
39Chronic myeloid leukemia_Homo sapiens_hsa052200.93058248
40Herpes simplex infection_Homo sapiens_hsa051680.92299345
41Biosynthesis of amino acids_Homo sapiens_hsa012300.90912891
42Colorectal cancer_Homo sapiens_hsa052100.90855197
43Cysteine and methionine metabolism_Homo sapiens_hsa002700.88411993
44Selenocompound metabolism_Homo sapiens_hsa004500.85788679
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85401353
46Small cell lung cancer_Homo sapiens_hsa052220.85080473
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84851053
48Pentose phosphate pathway_Homo sapiens_hsa000300.83498965
49Hippo signaling pathway_Homo sapiens_hsa043900.83316708
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82643988
51Prion diseases_Homo sapiens_hsa050200.81250372
52ErbB signaling pathway_Homo sapiens_hsa040120.76175124
53Basal cell carcinoma_Homo sapiens_hsa052170.74974477
54Bladder cancer_Homo sapiens_hsa052190.74949277
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.74055969
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71213054
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70308864
58Antigen processing and presentation_Homo sapiens_hsa046120.70137531
59Central carbon metabolism in cancer_Homo sapiens_hsa052300.69060456
60Non-small cell lung cancer_Homo sapiens_hsa052230.68166839
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66110372
62Notch signaling pathway_Homo sapiens_hsa043300.64622526
63Alcoholism_Homo sapiens_hsa050340.64017186
64TGF-beta signaling pathway_Homo sapiens_hsa043500.63830231
65Pyruvate metabolism_Homo sapiens_hsa006200.62835885
66Sulfur relay system_Homo sapiens_hsa041220.58597979
67Endometrial cancer_Homo sapiens_hsa052130.57675054
68Acute myeloid leukemia_Homo sapiens_hsa052210.56269737
69Hepatitis B_Homo sapiens_hsa051610.54178437
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53947833
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53896396
72Hedgehog signaling pathway_Homo sapiens_hsa043400.52289288
73Pancreatic cancer_Homo sapiens_hsa052120.49676449
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49674450
75Huntingtons disease_Homo sapiens_hsa050160.49398588
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49174795
77VEGF signaling pathway_Homo sapiens_hsa043700.48603924
78Lysine degradation_Homo sapiens_hsa003100.45201928
79Wnt signaling pathway_Homo sapiens_hsa043100.45015356
80Prostate cancer_Homo sapiens_hsa052150.44546084
81Vibrio cholerae infection_Homo sapiens_hsa051100.42529558
82Other glycan degradation_Homo sapiens_hsa005110.42500580
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42077422
84HIF-1 signaling pathway_Homo sapiens_hsa040660.40732448
85Arginine and proline metabolism_Homo sapiens_hsa003300.40371852
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40113403
87Adherens junction_Homo sapiens_hsa045200.39209504
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38672829
89Apoptosis_Homo sapiens_hsa042100.38600425
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.38199536
91Pathways in cancer_Homo sapiens_hsa052000.38055735
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35132517
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.34807836
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.33439693
95N-Glycan biosynthesis_Homo sapiens_hsa005100.33090796
96Glioma_Homo sapiens_hsa052140.33057300
97Renal cell carcinoma_Homo sapiens_hsa052110.32362955
98Carbon metabolism_Homo sapiens_hsa012000.30908222
99FoxO signaling pathway_Homo sapiens_hsa040680.28190565
100AMPK signaling pathway_Homo sapiens_hsa041520.28117134
101Prolactin signaling pathway_Homo sapiens_hsa049170.26646238
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26381335
103Folate biosynthesis_Homo sapiens_hsa007900.26290178
104Insulin signaling pathway_Homo sapiens_hsa049100.26143601
105Shigellosis_Homo sapiens_hsa051310.26074105
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25157818
107Proteoglycans in cancer_Homo sapiens_hsa052050.24009710
108Melanoma_Homo sapiens_hsa052180.23905883
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23408914
110Tight junction_Homo sapiens_hsa045300.23230672
111Viral myocarditis_Homo sapiens_hsa054160.23013501
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22557325
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.21553661
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.21386602
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21343552
116Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.18878849
117Dorso-ventral axis formation_Homo sapiens_hsa043200.15693161
118Fatty acid biosynthesis_Homo sapiens_hsa000610.15345221
119Estrogen signaling pathway_Homo sapiens_hsa049150.15326482

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