ZMPSTE24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1purine nucleobase biosynthetic process (GO:0009113)5.73492569
2folic acid metabolic process (GO:0046655)5.53458172
3folic acid transport (GO:0015884)5.53114537
4vitamin transmembrane transport (GO:0035461)5.51496172
5glycine metabolic process (GO:0006544)5.03454952
6nucleobase biosynthetic process (GO:0046112)5.02294594
7serine family amino acid catabolic process (GO:0009071)4.97480873
8ribosome assembly (GO:0042255)4.92571454
9pantothenate metabolic process (GO:0015939)4.91254872
10nuclear pore complex assembly (GO:0051292)4.90675525
11nuclear pore organization (GO:0006999)4.59641699
12serine family amino acid biosynthetic process (GO:0009070)4.27459527
13serine family amino acid metabolic process (GO:0009069)4.27011479
14regulation of spindle organization (GO:0090224)4.09470506
15L-serine metabolic process (GO:0006563)4.08005856
16modified amino acid transport (GO:0072337)4.06734296
17IMP biosynthetic process (GO:0006188)3.98263740
18mitotic metaphase plate congression (GO:0007080)3.94616981
19establishment of integrated proviral latency (GO:0075713)3.92896021
20cysteine metabolic process (GO:0006534)3.82251712
21cofactor transport (GO:0051181)3.80140997
22urate metabolic process (GO:0046415)3.80099498
23IMP metabolic process (GO:0046040)3.74240095
24pore complex assembly (GO:0046931)3.70337114
25negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.69359634
26negative regulation of ligase activity (GO:0051352)3.69359634
27CENP-A containing nucleosome assembly (GO:0034080)3.67289609
28protein localization to kinetochore (GO:0034501)3.66544554
29regulation of cellular amino acid metabolic process (GO:0006521)3.65891646
30L-methionine salvage (GO:0071267)3.65615521
31L-methionine biosynthetic process (GO:0071265)3.65615521
32amino acid salvage (GO:0043102)3.65615521
33biotin metabolic process (GO:0006768)3.65287573
34vitamin transport (GO:0051180)3.64067336
35UDP-N-acetylglucosamine metabolic process (GO:0006047)3.62825984
36histone-serine phosphorylation (GO:0035404)3.62522810
37cullin deneddylation (GO:0010388)3.62261327
38S-adenosylmethionine metabolic process (GO:0046500)3.59672389
39DNA double-strand break processing (GO:0000729)3.54653016
40non-recombinational repair (GO:0000726)3.54190926
41double-strand break repair via nonhomologous end joining (GO:0006303)3.54190926
42rRNA modification (GO:0000154)3.50735344
43maturation of 5.8S rRNA (GO:0000460)3.50405723
44sulfur amino acid biosynthetic process (GO:0000097)3.50060309
45intestinal epithelial cell development (GO:0060576)3.49475953
46chromatin remodeling at centromere (GO:0031055)3.49170934
47regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.48659603
48protein deneddylation (GO:0000338)3.47794569
49tRNA aminoacylation for protein translation (GO:0006418)3.46530935
50erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.45664973
51L-phenylalanine catabolic process (GO:0006559)3.45664973
52tRNA aminoacylation (GO:0043039)3.41519563
53amino acid activation (GO:0043038)3.41519563
54proteasome assembly (GO:0043248)3.41319800
55Golgi transport vesicle coating (GO:0048200)3.40955202
56COPI coating of Golgi vesicle (GO:0048205)3.40955202
57establishment of chromosome localization (GO:0051303)3.40264426
58lung-associated mesenchyme development (GO:0060484)3.39666610
59pyrimidine-containing compound transmembrane transport (GO:0072531)3.37122571
60erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.35960777
61L-phenylalanine metabolic process (GO:0006558)3.35960777
62nucleotide-sugar biosynthetic process (GO:0009226)3.34560655
63folic acid-containing compound metabolic process (GO:0006760)3.34389963
64sulfur amino acid catabolic process (GO:0000098)3.33979717
65transcription from mitochondrial promoter (GO:0006390)3.33023226
66amino-acid betaine metabolic process (GO:0006577)3.31604069
67signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.30909117
68intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.30909117
69signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.29615786
70signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.29615786
71signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.29615786
72ribosome biogenesis (GO:0042254)3.29486937
73regulation of mitotic spindle organization (GO:0060236)3.27623645
74DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.27354644
75NADH metabolic process (GO:0006734)3.25707280
76signal transduction involved in DNA integrity checkpoint (GO:0072401)3.23599228
77signal transduction involved in DNA damage checkpoint (GO:0072422)3.23599228
78heme transport (GO:0015886)3.22166260
79positive regulation of ligase activity (GO:0051351)3.21490329
80methionine metabolic process (GO:0006555)3.20789825
81lactate metabolic process (GO:0006089)3.19539844
82mitochondrial RNA metabolic process (GO:0000959)3.19456589
83DNA strand elongation involved in DNA replication (GO:0006271)3.19154869
84regulation of translation in response to stress (GO:0043555)3.18177217
85regulation of translational termination (GO:0006449)3.18033369
86aromatic amino acid family catabolic process (GO:0009074)3.18003093
87signal transduction involved in cell cycle checkpoint (GO:0072395)3.15501467
88mitotic nuclear envelope disassembly (GO:0007077)3.14743855
89formation of translation preinitiation complex (GO:0001731)3.14098260
90protein localization to chromosome, centromeric region (GO:0071459)3.12749988
91cellular protein complex localization (GO:0034629)3.11307266
92methionine biosynthetic process (GO:0009086)3.09981150
93regulation of ubiquitin-protein transferase activity (GO:0051438)3.09595687
94pteridine-containing compound biosynthetic process (GO:0042559)3.08472912
95homocysteine metabolic process (GO:0050667)3.07326812
96DNA strand elongation (GO:0022616)3.07133874
97response to X-ray (GO:0010165)3.05841230
98sulfur amino acid metabolic process (GO:0000096)3.05614823
99DNA catabolic process, exonucleolytic (GO:0000738)3.03837472
100blastocyst development (GO:0001824)3.02831050
101fructose metabolic process (GO:0006000)3.02377503
102mitotic sister chromatid cohesion (GO:0007064)3.01186996
103G1/S transition of mitotic cell cycle (GO:0000082)3.00981482
104cell cycle G1/S phase transition (GO:0044843)3.00981482
105positive regulation of chromosome segregation (GO:0051984)3.00482964
106telomere maintenance via semi-conservative replication (GO:0032201)3.00159150
107histone mRNA metabolic process (GO:0008334)2.99746983
108nucleobase-containing small molecule interconversion (GO:0015949)2.99698989
109establishment of viral latency (GO:0019043)2.99474895
110regulation of ligase activity (GO:0051340)2.99434416
111histone exchange (GO:0043486)2.95913258
112aromatic amino acid family metabolic process (GO:0009072)2.94509424
113indole-containing compound catabolic process (GO:0042436)2.93304172
114indolalkylamine catabolic process (GO:0046218)2.93304172
115tryptophan catabolic process (GO:0006569)2.93304172
116CDP-diacylglycerol metabolic process (GO:0046341)2.93138144
117nuclear envelope disassembly (GO:0051081)2.92768726
118membrane disassembly (GO:0030397)2.92768726
119mitochondrial DNA replication (GO:0006264)2.92123265
120mitotic sister chromatid segregation (GO:0000070)2.91882384
121regulation of centriole replication (GO:0046599)2.90731485
122regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.90357207
123autophagic vacuole assembly (GO:0000045)2.89671452
124metaphase plate congression (GO:0051310)2.89180880
125response to xenobiotic stimulus (GO:0009410)2.86472365
126tryptophan metabolic process (GO:0006568)2.86321984
127positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.83794927
128protein maturation by protein folding (GO:0022417)2.82255534
129termination of RNA polymerase I transcription (GO:0006363)2.81679083
130spindle checkpoint (GO:0031577)2.81277195
131anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.80884387
132signal peptide processing (GO:0006465)2.78446826
133kynurenine metabolic process (GO:0070189)2.77669782
134antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.76463740
135somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.75876919
136isotype switching (GO:0045190)2.75876919
137somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.75876919
138protein complex localization (GO:0031503)2.75129697
139regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.74375576
140regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.73871575
141regulation of mitotic spindle checkpoint (GO:1903504)2.73871575
142glyoxylate metabolic process (GO:0046487)2.73815430
143transcription elongation from RNA polymerase III promoter (GO:0006385)2.73560182
144termination of RNA polymerase III transcription (GO:0006386)2.73560182
145glycerol ether metabolic process (GO:0006662)2.73115211
146AMP metabolic process (GO:0046033)2.72795148
147telomere maintenance via recombination (GO:0000722)2.72440196
148DNA replication-independent nucleosome assembly (GO:0006336)2.72363601
149DNA replication-independent nucleosome organization (GO:0034724)2.72363601
150rRNA methylation (GO:0031167)2.72315669
151peptidyl-glutamic acid carboxylation (GO:0017187)2.71549599
152protein carboxylation (GO:0018214)2.71549599
153sister chromatid segregation (GO:0000819)2.69994893
154negative regulation of fibrinolysis (GO:0051918)2.69544452
155regulation of protein activation cascade (GO:2000257)2.69493708
156mitotic recombination (GO:0006312)2.69224317
157negative regulation of protein ubiquitination (GO:0031397)2.69204821
158regulation of translational fidelity (GO:0006450)2.69006536
159pteridine-containing compound metabolic process (GO:0042558)2.68432558
160transcription elongation from RNA polymerase I promoter (GO:0006362)2.66277993
161aspartate family amino acid biosynthetic process (GO:0009067)2.64049008
162regulation of complement activation (GO:0030449)2.60624745
163DNA replication checkpoint (GO:0000076)2.60430356
164negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.59773899
165transcription from RNA polymerase I promoter (GO:0006360)2.59254049
166COPII vesicle coating (GO:0048208)2.58510926
167transcription initiation from RNA polymerase I promoter (GO:0006361)2.53960072
168alpha-amino acid catabolic process (GO:1901606)2.53518414
169positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.53349789
170regulation of cholesterol homeostasis (GO:2000188)2.52935260
171water-soluble vitamin metabolic process (GO:0006767)2.52060301
172folic acid-containing compound biosynthetic process (GO:0009396)2.51091388
173aspartate family amino acid metabolic process (GO:0009066)2.50745715
174iron ion import (GO:0097286)2.49555312
175regulation of G0 to G1 transition (GO:0070316)2.49277125
176mannose metabolic process (GO:0006013)2.48442399
177positive regulation of autophagy (GO:0010508)2.47760194
178GMP metabolic process (GO:0046037)2.45378804
179bile acid biosynthetic process (GO:0006699)2.44914367
180lysine metabolic process (GO:0006553)2.41753090

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.25553928
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.13712091
3E2F7_22180533_ChIP-Seq_HELA_Human3.24585307
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.16102870
5CREB1_15753290_ChIP-ChIP_HEK293T_Human3.09259113
6RXR_22158963_ChIP-Seq_LIVER_Mouse3.03809266
7AR_21909140_ChIP-Seq_LNCAP_Human3.01543143
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.89347609
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.86691699
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.77837733
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.74177325
12* ETS1_20019798_ChIP-Seq_JURKAT_Human2.71119423
13* GABP_17652178_ChIP-ChIP_JURKAT_Human2.69790357
14CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.66919584
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.61172072
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.47152487
17* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.45540601
18* EST1_17652178_ChIP-ChIP_JURKAT_Human2.36567134
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.33338077
20EGR1_23403033_ChIP-Seq_LIVER_Mouse2.30129147
21LXR_22158963_ChIP-Seq_LIVER_Mouse2.12831674
22* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.03668879
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.01286284
24* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.96272756
25* VDR_23849224_ChIP-Seq_CD4+_Human1.95726749
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.94797473
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.93745262
28CLOCK_20551151_ChIP-Seq_293T_Human1.92899307
29PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.88618450
30ZNF263_19887448_ChIP-Seq_K562_Human1.88036064
31NELFA_20434984_ChIP-Seq_ESCs_Mouse1.85415039
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.80668233
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.76549549
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.74081501
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.71968555
36* GABP_19822575_ChIP-Seq_HepG2_Human1.66831493
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.65437531
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.63134635
39* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.61350416
40KDM5A_27292631_Chip-Seq_BREAST_Human1.59769510
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.59514697
42DCP1A_22483619_ChIP-Seq_HELA_Human1.56639322
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.51237735
44HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.50399357
45FOXP3_21729870_ChIP-Seq_TREG_Human1.48103832
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46392109
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.45537428
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.44758332
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44475279
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.43285226
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41932234
52KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.41606510
53FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.39495060
54* XRN2_22483619_ChIP-Seq_HELA_Human1.37910262
55SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.37001647
56TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36386007
57EGR1_19374776_ChIP-ChIP_THP-1_Human1.33796787
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.31814702
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29577408
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27264874
61* ELK1_22589737_ChIP-Seq_MCF10A_Human1.26911162
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26724472
63ELK1_19687146_ChIP-ChIP_HELA_Human1.25296505
64SALL4_18804426_ChIP-ChIP_XEN_Mouse1.24486232
65* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22440945
66GATA1_22025678_ChIP-Seq_K562_Human1.20447203
67EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.19315345
68E2F1_21310950_ChIP-Seq_MCF-7_Human1.18875353
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.17026789
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16146990
71POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.14909938
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14718322
73FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.12642630
74ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11022288
75MYC_18940864_ChIP-ChIP_HL60_Human1.10762949
76PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10722022
77THAP11_20581084_ChIP-Seq_MESCs_Mouse1.10035880
78EWS_26573619_Chip-Seq_HEK293_Human1.09862726
79TFEB_21752829_ChIP-Seq_HELA_Human1.08570382
80SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07963524
81* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07723956
82ELF5_23300383_ChIP-Seq_T47D_Human1.07169810
83RARG_19884340_ChIP-ChIP_MEFs_Mouse1.06596211
84ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04424753
85SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.04033747
86NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03787835
87* SOX17_20123909_ChIP-Seq_XEN_Mouse1.01902822
88TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01577257
89NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.00292082
90NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.00222881
91BRD4_25478319_ChIP-Seq_HGPS_Human0.99244186
92* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99152862
93* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98803663
94KAP1_22055183_ChIP-Seq_ESCs_Mouse0.98560471
95MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.97771395
96ATF3_27146783_Chip-Seq_COLON_Human0.95621084
97HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95033778
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93168026
99SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.92060684
100SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.92060684
101TP63_17297297_ChIP-ChIP_HaCaT_Human0.91955172
102ESR2_21235772_ChIP-Seq_MCF-7_Human0.90616244
103SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.90310932
104* GATA4_25053715_ChIP-Seq_YYC3_Human0.90229032
105MYB_21317192_ChIP-Seq_ERMYB_Mouse0.90223271
106EZH2_27294783_Chip-Seq_NPCs_Mouse0.89873792
107NANOG_16153702_ChIP-ChIP_HESCs_Human0.89736402
108SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89070107
109HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88170250
110CHD1_26751641_Chip-Seq_LNCaP_Human0.87376729
111* TTF2_22483619_ChIP-Seq_HELA_Human0.86565540
112ESR1_21235772_ChIP-Seq_MCF-7_Human0.86289421
113BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.85956791
114YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85787498
115DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85105232
116NFE2_27457419_Chip-Seq_LIVER_Mouse0.84757709
117SUZ12_27294783_Chip-Seq_NPCs_Mouse0.84534965
118BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84396992
119E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.84296960
120NOTCH1_21737748_ChIP-Seq_TLL_Human0.83965380
121SALL1_21062744_ChIP-ChIP_HESCs_Human0.83008208
122TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.81927211
123FUS_26573619_Chip-Seq_HEK293_Human0.81564024
124POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.81011742
125* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.80746699
126CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.80732273
127ERG_20887958_ChIP-Seq_HPC-7_Mouse0.80438424
128* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.79393230
129FOXM1_26456572_ChIP-Seq_MCF-7_Human0.78287714
130ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.78154098
131CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.76123206
132SALL4_22934838_ChIP-ChIP_CD34+_Human0.75939197

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009840_abnormal_foam_cell4.28235597
2MP0002139_abnormal_hepatobiliary_system4.02937538
3MP0003693_abnormal_embryo_hatching3.87902445
4MP0005360_urolithiasis3.51871786
5MP0005365_abnormal_bile_salt3.36626060
6MP0008057_abnormal_DNA_replication3.31427153
7MP0005085_abnormal_gallbladder_physiolo3.11191399
8MP0003718_maternal_effect3.07415635
9MP0009697_abnormal_copulation3.01704164
10MP0003806_abnormal_nucleotide_metabolis2.59686627
11MP0008260_abnormal_autophagy2.36610691
12MP0005332_abnormal_amino_acid2.35623692
13MP0008875_abnormal_xenobiotic_pharmacok2.34369874
14MP0004957_abnormal_blastocyst_morpholog2.25130487
15MP0005058_abnormal_lysosome_morphology2.23726222
16MP0005451_abnormal_body_composition2.16913331
17MP0003195_calcinosis2.16912667
18MP0002877_abnormal_melanocyte_morpholog2.05367077
19* MP0003111_abnormal_nucleus_morphology2.02847739
20MP0004019_abnormal_vitamin_homeostasis1.97136318
21MP0010329_abnormal_lipoprotein_level1.79327377
22MP0003252_abnormal_bile_duct1.73793955
23MP0004272_abnormal_basement_membrane1.67576814
24MP0005395_other_phenotype1.64710644
25* MP0003786_premature_aging1.63132087
26MP0000609_abnormal_liver_physiology1.62024013
27MP0001756_abnormal_urination1.61893293
28MP0009643_abnormal_urine_homeostasis1.57032136
29MP0003191_abnormal_cellular_cholesterol1.54052833
30MP0002090_abnormal_vision1.47746646
31MP0000427_abnormal_hair_cycle1.47250457
32MP0003077_abnormal_cell_cycle1.46641937
33MP0002796_impaired_skin_barrier1.45787172
34MP0009384_cardiac_valve_regurgitation1.43045094
35MP0003656_abnormal_erythrocyte_physiolo1.41778170
36MP0001666_abnormal_nutrient_absorption1.39886020
37MP0001730_embryonic_growth_arrest1.37566169
38MP0003186_abnormal_redox_activity1.30148016
39* MP0005319_abnormal_enzyme/_coenzyme1.29679813
40MP0001764_abnormal_homeostasis1.27894890
41MP0010094_abnormal_chromosome_stability1.27665635
42MP0004782_abnormal_surfactant_physiolog1.25924718
43MP0006035_abnormal_mitochondrial_morpho1.25234333
44MP0006036_abnormal_mitochondrial_physio1.19377049
45MP0002396_abnormal_hematopoietic_system1.17646162
46MP0005408_hypopigmentation1.16608257
47MP0000383_abnormal_hair_follicle1.16226583
48MP0009333_abnormal_splenocyte_physiolog1.16098615
49MP0003705_abnormal_hypodermis_morpholog1.15553130
50MP0002118_abnormal_lipid_homeostasis1.14777406
51MP0008932_abnormal_embryonic_tissue1.13598314
52MP0002084_abnormal_developmental_patter1.10495643
53MP0005380_embryogenesis_phenotype1.10169102
54MP0001672_abnormal_embryogenesis/_devel1.10169102
55MP0005220_abnormal_exocrine_pancreas1.10035591
56MP0000569_abnormal_digit_pigmentation1.09687972
57MP0000598_abnormal_liver_morphology1.09676274
58MP0002006_tumorigenesis1.09666418
59* MP0001216_abnormal_epidermal_layer1.09183847
60MP0005501_abnormal_skin_physiology1.09167188
61MP0010307_abnormal_tumor_latency1.08381379
62MP0002102_abnormal_ear_morphology1.06147443
63MP0003984_embryonic_growth_retardation1.05586762
64MP0006054_spinal_hemorrhage1.05198342
65MP0002088_abnormal_embryonic_growth/wei1.04695820
66MP0002166_altered_tumor_susceptibility1.04065994
67MP0010678_abnormal_skin_adnexa1.01906686
68MP0005023_abnormal_wound_healing1.01079838
69MP0003890_abnormal_embryonic-extraembry1.00494941
70MP0008438_abnormal_cutaneous_collagen1.00249433
71MP0003221_abnormal_cardiomyocyte_apopto0.98978626
72MP0000579_abnormal_nail_morphology0.97956617
73MP0000465_gastrointestinal_hemorrhage0.97732841
74MP0004185_abnormal_adipocyte_glucose0.97253314
75MP0002138_abnormal_hepatobiliary_system0.96137158
76MP0005377_hearing/vestibular/ear_phenot0.94043174
77MP0003878_abnormal_ear_physiology0.94043174
78MP0005397_hematopoietic_system_phenotyp0.93495788
79MP0001545_abnormal_hematopoietic_system0.93495788
80MP0009672_abnormal_birth_weight0.92635856
81MP0002136_abnormal_kidney_physiology0.91909409
82MP0002085_abnormal_embryonic_tissue0.91810616
83MP0005636_abnormal_mineral_homeostasis0.89804004
84MP0004264_abnormal_extraembryonic_tissu0.89355036
85MP0008007_abnormal_cellular_replicative0.89023616
86MP0000490_abnormal_crypts_of0.88602265
87* MP0001542_abnormal_bone_strength0.88160832
88MP0000350_abnormal_cell_proliferation0.87732681
89MP0003937_abnormal_limbs/digits/tail_de0.86955707
90MP0000762_abnormal_tongue_morphology0.86618715
91MP0001697_abnormal_embryo_size0.86330697
92MP0005197_abnormal_uvea_morphology0.86305902
93MP0001915_intracranial_hemorrhage0.85936357
94MP0002080_prenatal_lethality0.85803580
95MP0000537_abnormal_urethra_morphology0.85168907
96MP0005187_abnormal_penis_morphology0.84211402
97MP0003300_gastrointestinal_ulcer0.83895625
98MP0003448_altered_tumor_morphology0.81313828
99MP0005083_abnormal_biliary_tract0.80959308
100MP0002086_abnormal_extraembryonic_tissu0.80814934
101MP0003567_abnormal_fetal_cardiomyocyte0.79673526
102MP0000627_abnormal_mammary_gland0.79671660
103MP0003566_abnormal_cell_adhesion0.79564130
104MP0004084_abnormal_cardiac_muscle0.78933545
105MP0010352_gastrointestinal_tract_polyps0.78839044
106MP0005275_abnormal_skin_tensile0.78595695
107MP0002254_reproductive_system_inflammat0.77200107
108MP0001958_emphysema0.76975788
109MP0009780_abnormal_chondrocyte_physiolo0.76001933
110* MP0005384_cellular_phenotype0.75606271
111MP0003123_paternal_imprinting0.75430269
112MP0000604_amyloidosis0.75036487
113MP0003941_abnormal_skin_development0.74462029
114MP0000313_abnormal_cell_death0.74148900
115MP0002160_abnormal_reproductive_system0.73906577
116MP0010771_integument_phenotype0.73666387
117MP0003868_abnormal_feces_composition0.73307947
118MP0006072_abnormal_retinal_apoptosis0.73220711
119MP0001293_anophthalmia0.72576437
120MP0004233_abnormal_muscle_weight0.72162996
121MP0001191_abnormal_skin_condition0.71666010
122MP0000647_abnormal_sebaceous_gland0.71358516
123MP0002060_abnormal_skin_morphology0.70291902
124MP0001727_abnormal_embryo_implantation0.69836678
125* MP0008469_abnormal_protein_level0.69219595
126MP0004197_abnormal_fetal_growth/weight/0.68407259
127MP0008058_abnormal_DNA_repair0.67779936
128MP0003950_abnormal_plasma_membrane0.67053985
129MP0002282_abnormal_trachea_morphology0.66698774
130MP0009053_abnormal_anal_canal0.66566271
131MP0000750_abnormal_muscle_regeneration0.66334708
132MP0002019_abnormal_tumor_incidence0.66241480
133MP0002098_abnormal_vibrissa_morphology0.65224047
134MP0000428_abnormal_craniofacial_morphol0.65131995
135MP0004043_abnormal_pH_regulation0.63906573
136MP0001243_abnormal_dermal_layer0.62813458
137* MP0000377_abnormal_hair_follicle0.61808664
138MP0000358_abnormal_cell_content/0.61766255
139MP0004947_skin_inflammation0.60530114
140MP0009278_abnormal_bone_marrow0.58989525
141* MP0001661_extended_life_span0.58352242
142MP0010234_abnormal_vibrissa_follicle0.58151474
143MP0002092_abnormal_eye_morphology0.57010698
144MP0001881_abnormal_mammary_gland0.56000189

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinemia (HP:0002154)6.04919741
2Hyperglycinuria (HP:0003108)5.25606305
3Abnormality of serine family amino acid metabolism (HP:0010894)4.87119993
4Abnormality of glycine metabolism (HP:0010895)4.87119993
5Gout (HP:0001997)4.77371223
6Abnormality of serum amino acid levels (HP:0003112)3.81633195
7Increased serum pyruvate (HP:0003542)3.72414319
8Xanthomatosis (HP:0000991)3.61313454
9Abnormality of aromatic amino acid family metabolism (HP:0004338)3.57591986
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.43940250
11Abnormality of glycolysis (HP:0004366)3.42556467
12Hyperlipoproteinemia (HP:0010980)3.35068458
13Chromsome breakage (HP:0040012)3.33819054
14Carpal bone hypoplasia (HP:0001498)3.26315050
15Abnormality of monocarboxylic acid metabolism (HP:0010996)3.22539241
16Deep venous thrombosis (HP:0002625)3.20750475
17Intrahepatic cholestasis (HP:0001406)3.19711965
18Increased hepatocellular lipid droplets (HP:0006565)3.18528323
19Impulsivity (HP:0100710)3.15400864
20Birth length less than 3rd percentile (HP:0003561)3.07569253
21Breast hypoplasia (HP:0003187)3.06416084
22Hypobetalipoproteinemia (HP:0003563)2.87661802
23Atrioventricular block (HP:0001678)2.86350997
24Lipid accumulation in hepatocytes (HP:0006561)2.84239223
25Abnormality of chromosome stability (HP:0003220)2.82084224
26Pustule (HP:0200039)2.78856283
27Cervical subluxation (HP:0003308)2.77489008
28Prolonged partial thromboplastin time (HP:0003645)2.77129894
29Cerebral hypomyelination (HP:0006808)2.76710803
30Abnormality of the intrinsic pathway (HP:0010989)2.76091615
31Hyperuricemia (HP:0002149)2.73622207
32Increased purine levels (HP:0004368)2.73622207
33Abnormal umbilical cord blood vessels (HP:0011403)2.73043294
34Single umbilical artery (HP:0001195)2.73043294
35Abnormality of the fetal cardiovascular system (HP:0010948)2.73043294
36Megaloblastic anemia (HP:0001889)2.72785590
37Abnormality of the preputium (HP:0100587)2.68340837
38Abnormal cartilage morphology (HP:0002763)2.66981047
39Abnormality of purine metabolism (HP:0004352)2.65676780
40Reduced antithrombin III activity (HP:0001976)2.63875181
41Multiple enchondromatosis (HP:0005701)2.61647660
42Spastic paraparesis (HP:0002313)2.58429637
43Abnormality of sulfur amino acid metabolism (HP:0004339)2.56569008
44Tetraplegia (HP:0002445)2.55884051
45Hypolipoproteinemia (HP:0010981)2.52733660
46Pancreatic islet-cell hyperplasia (HP:0004510)2.49925776
47Irregular epiphyses (HP:0010582)2.49857998
48Hyperammonemia (HP:0001987)2.46376171
49Meckel diverticulum (HP:0002245)2.44894932
50Hypoglycemic coma (HP:0001325)2.43466829
51Hypoalphalipoproteinemia (HP:0003233)2.43235738
52Renal Fanconi syndrome (HP:0001994)2.42564428
53Nonimmune hydrops fetalis (HP:0001790)2.40552885
54Secondary amenorrhea (HP:0000869)2.39728221
55Abnormality of fatty-acid metabolism (HP:0004359)2.38833716
56Abnormality of the common coagulation pathway (HP:0010990)2.37682470
57Prolonged neonatal jaundice (HP:0006579)2.37166532
58Fat malabsorption (HP:0002630)2.35786789
59Myocardial infarction (HP:0001658)2.35640524
60Abnormality of nucleobase metabolism (HP:0010932)2.33917161
61Methylmalonic acidemia (HP:0002912)2.33568666
62Small epiphyses (HP:0010585)2.30617925
63Symptomatic seizures (HP:0011145)2.30567255
64Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.28416652
65Postnatal microcephaly (HP:0005484)2.27716766
66Abnormality of the proximal phalanges of the hand (HP:0009834)2.26830962
67* Sparse eyelashes (HP:0000653)2.26342818
68Irritability (HP:0000737)2.25369953
69Palpitations (HP:0001962)2.24407836
70Type I transferrin isoform profile (HP:0003642)2.22623391
71Abnormality of the anterior horn cell (HP:0006802)2.22509065
72Degeneration of anterior horn cells (HP:0002398)2.22509065
73Proximal tubulopathy (HP:0000114)2.21516875
74Overlapping toe (HP:0001845)2.21196427
75Muscle fiber splitting (HP:0003555)2.20944169
76Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.20715327
77Ankle contracture (HP:0006466)2.20677341
78Death in infancy (HP:0001522)2.20535014
79Aplasia/Hypoplasia involving the musculature (HP:0001460)2.20478229
80Abnormal lung lobation (HP:0002101)2.20393870
81Increased CSF lactate (HP:0002490)2.18944715
82Abnormality of the ileum (HP:0001549)2.18915329
83Hypokinesia (HP:0002375)2.16263362
84Aplasia/Hypoplasia of the uvula (HP:0010293)2.15724862
85Abnormal biliary tract morphology (HP:0012440)2.15325386
86Selective tooth agenesis (HP:0001592)2.12879551
87Onycholysis (HP:0001806)2.11319915
88Abnormal foot bone ossification (HP:0010675)2.11037403
89Alopecia of scalp (HP:0002293)2.10806397
90Increased serum lactate (HP:0002151)2.10360521
91Tetraparesis (HP:0002273)2.09747277
92Flat capital femoral epiphysis (HP:0003370)2.09009178
93Posterior subcapsular cataract (HP:0007787)2.08947317
94Abnormality of aspartate family amino acid metabolism (HP:0010899)2.08128277
95Duodenal stenosis (HP:0100867)2.07717078
96Small intestinal stenosis (HP:0012848)2.07717078
97Global brain atrophy (HP:0002283)2.07418468
98Abnormality of methionine metabolism (HP:0010901)2.06818283
99Hyperinsulinemic hypoglycemia (HP:0000825)2.06724361
100Complement deficiency (HP:0004431)2.06670478
101Lethargy (HP:0001254)2.06575876
102Steatorrhea (HP:0002570)2.05802337
103Abnormality of homocysteine metabolism (HP:0010919)2.05000567
104Homocystinuria (HP:0002156)2.05000567
105Short middle phalanx of the 5th finger (HP:0004220)2.04826799
106Delayed epiphyseal ossification (HP:0002663)2.02618230
107Hypoglycemic seizures (HP:0002173)2.02426849
108* Abnormality of the umbilical cord (HP:0010881)2.01982225
109Aplasia/hypoplasia of the humerus (HP:0006507)2.01074762
110Abnormality of glutamine family amino acid metabolism (HP:0010902)2.00483602
111Conjunctival telangiectasia (HP:0000524)1.99736920
112Protuberant abdomen (HP:0001538)1.99607664
113* Abnormalities of placenta or umbilical cord (HP:0001194)1.99382219
114Progressive muscle weakness (HP:0003323)1.99213623
115Abnormality of dicarboxylic acid metabolism (HP:0010995)1.98330178
116Dicarboxylic aciduria (HP:0003215)1.98330178
117Cerebral edema (HP:0002181)1.97585020
118Abnormal glycosylation (HP:0012345)1.96527766
119Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.96527766
120Abnormal protein N-linked glycosylation (HP:0012347)1.96527766
121Abnormal protein glycosylation (HP:0012346)1.96527766
122Polycythemia (HP:0001901)1.95847235
123Abnormal tarsal ossification (HP:0008369)1.95526454
124Paraparesis (HP:0002385)1.95199115
125Patent foramen ovale (HP:0001655)1.94768185
126Rhabdomyosarcoma (HP:0002859)1.93944209
127Ileus (HP:0002595)1.92958992
128* Rough bone trabeculation (HP:0100670)1.92569162
129Ependymoma (HP:0002888)1.92181757
130Abnormality of vitamin B metabolism (HP:0004340)1.91636280
131Autoamputation (HP:0001218)1.91420768
132Renal cortical cysts (HP:0000803)1.90973441
133Microretrognathia (HP:0000308)1.90596140
134Microvesicular hepatic steatosis (HP:0001414)1.90521387
135Biliary tract neoplasm (HP:0100574)1.90194529
136Bundle branch block (HP:0011710)1.89466943
137Abnormality of oral frenula (HP:0000190)1.88221552
138Nausea (HP:0002018)1.88183515
139Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.86801514
140Abnormality of alanine metabolism (HP:0010916)1.86268304
141Hyperalaninemia (HP:0003348)1.86268304
142Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.86268304
143* Hyperglycemia (HP:0003074)1.86209272
144Acute encephalopathy (HP:0006846)1.85548024
145Hypoplasia of the capital femoral epiphysis (HP:0003090)1.84624130
146Premature ovarian failure (HP:0008209)1.82396136
147Abnormality of the vitamin B12 metabolism (HP:0004341)1.82378981
148Right ventricular cardiomyopathy (HP:0011663)1.81721377
149Pancytopenia (HP:0001876)1.81696569
150Abnormality of the duodenum (HP:0002246)1.80764880
151Breast carcinoma (HP:0003002)1.80700713
152Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.80641479
153Absent epiphyses (HP:0010577)1.80641479
154Personality changes (HP:0000751)1.80148690
155Abnormal auditory evoked potentials (HP:0006958)1.79596568
156Septate vagina (HP:0001153)1.78006518
157Spastic diplegia (HP:0001264)1.77082191
158Abnormal spermatogenesis (HP:0008669)1.76772406
159Neoplasm of the adrenal gland (HP:0100631)1.76604053
160Follicular hyperkeratosis (HP:0007502)1.76185140
161Abnormality of subcutaneous fat tissue (HP:0001001)1.76151635
162Cardiovascular calcification (HP:0011915)1.75833811
163Conjugated hyperbilirubinemia (HP:0002908)1.75528495
164Spinal muscular atrophy (HP:0007269)1.75235835
165Ovarian neoplasm (HP:0100615)1.74805950
166CNS hypomyelination (HP:0003429)1.74685108
167Vascular calcification (HP:0004934)1.73816261
168CNS demyelination (HP:0007305)1.73712183
169* Stillbirth (HP:0003826)1.72275761
170Restlessness (HP:0000711)1.72012118
171Thoracolumbar scoliosis (HP:0002944)1.71301329
172Short humerus (HP:0005792)1.71276572
173Deviation of the thumb (HP:0009603)1.70166703
174Increased density of long bones (HP:0006392)1.68877449
175Microglossia (HP:0000171)1.66797393
176Acute necrotizing encephalopathy (HP:0006965)1.66134364
177Insidious onset (HP:0003587)1.65251807
178Termporal pattern (HP:0011008)1.65251807
179Neoplasm of the peripheral nervous system (HP:0100007)1.64843618
180Uterine neoplasm (HP:0010784)1.64693211

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.53394374
2WEE14.04551428
3EPHA23.52182651
4PBK3.06690138
5AKT33.05154571
6TSSK62.80640092
7BRSK22.76646170
8EIF2AK12.72986488
9PLK42.70154395
10TRIM282.62733874
11NEK22.56654886
12EIF2AK32.17204178
13SCYL22.08000623
14STK32.01903557
15NEK11.93373731
16NME21.92854715
17BCKDK1.76860443
18CDC71.66802072
19ERBB31.62954058
20TTK1.61763212
21PLK31.59532507
22MAP3K121.52418144
23STK161.52235961
24IRAK31.51916292
25STK38L1.46891921
26MAP3K31.46673521
27LATS11.43039526
28SRPK11.41951656
29PLK11.37485300
30FGFR41.37210638
31BCR1.34760628
32PIM21.34433576
33ZAK1.34198479
34PDK31.26541462
35PDK41.26541462
36PNCK1.20687262
37BRSK11.18087256
38NME11.15127772
39STK101.14071780
40AURKB1.13797258
41TAF11.12563312
42PDK21.12431517
43RPS6KA41.09046831
44NUAK11.08810469
45SIK31.08443576
46TAOK31.07659875
47PLK21.07221366
48ACVR1B1.06902069
49BMPR1B1.03513785
50MKNK11.01088417
51DYRK30.96758619
52MAP3K80.96009078
53STK240.93301364
54FRK0.90811214
55ALK0.90429052
56NEK90.90413386
57TESK20.90033385
58CDK40.88362093
59PINK10.88279921
60KDR0.86452662
61VRK20.86228370
62TRIB30.85654066
63MKNK20.83346488
64PAK40.79835009
65CSNK1G10.79183343
66MYLK0.78597150
67FER0.77763644
68ERN10.77125861
69CSNK1A1L0.75926135
70CLK10.74665276
71CSNK1G30.74118453
72CCNB10.73300184
73AURKA0.72457497
74MET0.71865368
75TRPM70.71264375
76MELK0.71119246
77CDK60.66720555
78CHEK20.65164904
79MAP2K30.64565653
80FGFR10.63703087
81WNK30.63015491
82PAK20.61687281
83LIMK10.61390796
84CDK70.61374185
85ZAP700.61134774
86TGFBR10.60869719
87ATR0.60849602
88LRRK20.59457430
89BMPR20.58921364
90TESK10.57936875
91MST1R0.57377448
92TGFBR20.56919650
93STK390.56765388
94PIM10.54856134
95EPHB10.54171908
96PRKCI0.53636202
97MTOR0.52561505
98CHEK10.52364247
99ATM0.52231061
100VRK10.52058857
101LATS20.51601265
102MAPKAPK30.50728651
103PAK10.50529058
104EIF2AK20.50073871
105DDR20.49634582
106MAP2K20.47797792
107GSK3A0.47579275
108LMTK20.47352866
109PRKAA10.47003167
110PASK0.46146578
111MAP3K50.46080115
112EPHA30.44951350
113TYK20.43694094
114TEC0.43618267
115MST40.43442631
116ERBB40.42612600
117CSNK1E0.41537291
118RPS6KB20.41399892
119CSNK2A10.41165408
120ABL20.40106875
121CAMKK20.39960827
122ILK0.39737345
123PTK20.38302581
124CSNK2A20.38260122
125BRAF0.37514261
126MAPKAPK50.37248720
127CSNK1G20.36275862
128STK40.33869698
129TXK0.33551975
130OXSR10.32646169
131NLK0.32610683
132DMPK0.31915082
133BRD40.31905123
134CDK20.31652799
135INSRR0.30009215
136PDGFRA0.29544371
137PRKCE0.28443244
138GRK10.28257964
139CDK80.25818905

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.63666499
2Glycine, serine and threonine metabolism_Homo sapiens_hsa002603.13619447
3Mismatch repair_Homo sapiens_hsa034302.89859139
4Non-homologous end-joining_Homo sapiens_hsa034502.81953593
5Folate biosynthesis_Homo sapiens_hsa007902.65353869
6Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.58232330
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.56160467
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.48454014
9Proteasome_Homo sapiens_hsa030502.44678891
10RNA polymerase_Homo sapiens_hsa030202.36632646
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.15456502
12Vitamin digestion and absorption_Homo sapiens_hsa049772.13466165
13Drug metabolism - other enzymes_Homo sapiens_hsa009832.01764044
14Regulation of autophagy_Homo sapiens_hsa041402.00119779
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.91851846
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.81609869
17RNA transport_Homo sapiens_hsa030131.71680524
18Selenocompound metabolism_Homo sapiens_hsa004501.67584986
19Cysteine and methionine metabolism_Homo sapiens_hsa002701.62534328
20Pentose phosphate pathway_Homo sapiens_hsa000301.59327821
21RNA degradation_Homo sapiens_hsa030181.56765562
22Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.51358203
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48198090
24Nitrogen metabolism_Homo sapiens_hsa009101.44073670
25Butanoate metabolism_Homo sapiens_hsa006501.43126203
26Complement and coagulation cascades_Homo sapiens_hsa046101.40172972
27Pyrimidine metabolism_Homo sapiens_hsa002401.35277037
28Arginine biosynthesis_Homo sapiens_hsa002201.32731015
29Glycerophospholipid metabolism_Homo sapiens_hsa005641.32001463
30Tryptophan metabolism_Homo sapiens_hsa003801.28302317
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27465121
32Biosynthesis of amino acids_Homo sapiens_hsa012301.24122295
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.24040696
34Fatty acid degradation_Homo sapiens_hsa000711.23837169
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.22813812
36Fanconi anemia pathway_Homo sapiens_hsa034601.22800041
37Steroid biosynthesis_Homo sapiens_hsa001001.21867246
38One carbon pool by folate_Homo sapiens_hsa006701.19475134
39beta-Alanine metabolism_Homo sapiens_hsa004101.19134990
40Histidine metabolism_Homo sapiens_hsa003401.17464249
41Peroxisome_Homo sapiens_hsa041461.13184818
42N-Glycan biosynthesis_Homo sapiens_hsa005101.10015766
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.09994858
44Cell cycle_Homo sapiens_hsa041101.09533208
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.09463619
46Retinol metabolism_Homo sapiens_hsa008301.08233497
47Sulfur metabolism_Homo sapiens_hsa009201.07359994
48Fatty acid metabolism_Homo sapiens_hsa012121.06614198
49Arginine and proline metabolism_Homo sapiens_hsa003301.06196827
50Caffeine metabolism_Homo sapiens_hsa002321.03246874
51Carbon metabolism_Homo sapiens_hsa012001.03215625
52Glutathione metabolism_Homo sapiens_hsa004801.03061001
53Steroid hormone biosynthesis_Homo sapiens_hsa001401.02501294
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01299331
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.99388912
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98543752
57Lysosome_Homo sapiens_hsa041420.96354679
58p53 signaling pathway_Homo sapiens_hsa041150.93546946
59Sulfur relay system_Homo sapiens_hsa041220.92612478
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.92409468
61mRNA surveillance pathway_Homo sapiens_hsa030150.91444925
62Staphylococcus aureus infection_Homo sapiens_hsa051500.90666587
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89771658
64Protein export_Homo sapiens_hsa030600.89316869
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87617266
66Fatty acid elongation_Homo sapiens_hsa000620.86928896
67Chemical carcinogenesis_Homo sapiens_hsa052040.85519883
68Propanoate metabolism_Homo sapiens_hsa006400.84466702
69PPAR signaling pathway_Homo sapiens_hsa033200.80480207
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79039835
71Spliceosome_Homo sapiens_hsa030400.75939560
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75900973
73Starch and sucrose metabolism_Homo sapiens_hsa005000.75080760
74Fructose and mannose metabolism_Homo sapiens_hsa000510.73414751
75Purine metabolism_Homo sapiens_hsa002300.71582855
76Oxidative phosphorylation_Homo sapiens_hsa001900.69839821
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69458354
78DNA replication_Homo sapiens_hsa030300.67785172
79Antigen processing and presentation_Homo sapiens_hsa046120.67105901
80Glycerolipid metabolism_Homo sapiens_hsa005610.66991230
81Basal transcription factors_Homo sapiens_hsa030220.66420704
82Renin-angiotensin system_Homo sapiens_hsa046140.62958552
83Oocyte meiosis_Homo sapiens_hsa041140.62717247
84Metabolic pathways_Homo sapiens_hsa011000.61432543
85Fat digestion and absorption_Homo sapiens_hsa049750.60935822
86Parkinsons disease_Homo sapiens_hsa050120.60721140
87TGF-beta signaling pathway_Homo sapiens_hsa043500.60633511
88Epstein-Barr virus infection_Homo sapiens_hsa051690.55207206
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.53959522
90Nucleotide excision repair_Homo sapiens_hsa034200.52669503
91Base excision repair_Homo sapiens_hsa034100.52649764
92Sphingolipid metabolism_Homo sapiens_hsa006000.52121283
93Vibrio cholerae infection_Homo sapiens_hsa051100.50333719
94Huntingtons disease_Homo sapiens_hsa050160.49657593
95Legionellosis_Homo sapiens_hsa051340.48864609
96Fatty acid biosynthesis_Homo sapiens_hsa000610.47374673
97Phenylalanine metabolism_Homo sapiens_hsa003600.45726049
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45476333
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44854213
100Thyroid cancer_Homo sapiens_hsa052160.44470196
101* Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43650634
102Bile secretion_Homo sapiens_hsa049760.43277496
103Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42930599
104ABC transporters_Homo sapiens_hsa020100.42831667
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42077869
106Linoleic acid metabolism_Homo sapiens_hsa005910.38935256
107Adherens junction_Homo sapiens_hsa045200.34910603
108Pyruvate metabolism_Homo sapiens_hsa006200.34742689
109Homologous recombination_Homo sapiens_hsa034400.34631060
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34511116
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34381993
112Alzheimers disease_Homo sapiens_hsa050100.34253743
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33832437
114Tyrosine metabolism_Homo sapiens_hsa003500.33133779
115Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31456008
116Galactose metabolism_Homo sapiens_hsa000520.30425140
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.29721918
118Arachidonic acid metabolism_Homo sapiens_hsa005900.28832147
119Shigellosis_Homo sapiens_hsa051310.28802142
120Circadian rhythm_Homo sapiens_hsa047100.28251635
121Proteoglycans in cancer_Homo sapiens_hsa052050.24629413
122Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.24441658
123ECM-receptor interaction_Homo sapiens_hsa045120.23628962
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23328104
125Other glycan degradation_Homo sapiens_hsa005110.22465095
126Small cell lung cancer_Homo sapiens_hsa052220.22239146
127SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21805227
128Mineral absorption_Homo sapiens_hsa049780.21044466

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