ZKSCAN8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)6.55914164
2pore complex assembly (GO:0046931)5.26113478
3regulation of histone H3-K27 methylation (GO:0061085)5.12097420
4regulation of nucleobase-containing compound transport (GO:0032239)4.60934358
5monoubiquitinated protein deubiquitination (GO:0035520)4.50692276
6insulin-like growth factor receptor signaling pathway (GO:0048009)4.44867404
7DNA topological change (GO:0006265)4.17700032
8positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)4.07792956
9mitotic sister chromatid cohesion (GO:0007064)4.05348820
10interkinetic nuclear migration (GO:0022027)3.94007621
11glucocorticoid receptor signaling pathway (GO:0042921)3.77714069
12dosage compensation (GO:0007549)3.72554074
13DNA unwinding involved in DNA replication (GO:0006268)3.72335713
14regulation of NFAT protein import into nucleus (GO:0051532)3.65498395
15sister chromatid segregation (GO:0000819)3.56055987
16histone H3-K4 trimethylation (GO:0080182)3.49940079
17mitotic chromosome condensation (GO:0007076)3.49355607
18lens morphogenesis in camera-type eye (GO:0002089)3.44546691
19positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.39825373
20positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.39825373
21positive regulation of mitotic sister chromatid separation (GO:1901970)3.39825373
22dorsal/ventral axis specification (GO:0009950)3.38518594
23regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.35836641
24regulation of histone methylation (GO:0031060)3.34618769
25regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.29258567
26histone demethylation (GO:0016577)3.25162117
27regulation of histone H3-K4 methylation (GO:0051569)3.23743326
28cytoplasmic mRNA processing body assembly (GO:0033962)3.22915480
29histone H3-K36 demethylation (GO:0070544)3.21010712
30stress granule assembly (GO:0034063)3.20795938
31nucleus localization (GO:0051647)3.20316590
32histone lysine methylation (GO:0034968)3.19640331
33corticosteroid receptor signaling pathway (GO:0031958)3.18400756
34histone H3-K9 modification (GO:0061647)3.11279770
35mRNA stabilization (GO:0048255)3.11232368
36RNA stabilization (GO:0043489)3.11232368
37gastrulation with mouth forming second (GO:0001702)3.10848232
38negative regulation of erythrocyte differentiation (GO:0045647)3.08806428
39DNA duplex unwinding (GO:0032508)3.08732470
40establishment of nucleus localization (GO:0040023)3.08019993
41regulation of mitotic spindle organization (GO:0060236)3.07715022
42exocrine pancreas development (GO:0031017)3.07421242
43histone H3-K9 methylation (GO:0051567)3.05757244
44embryonic process involved in female pregnancy (GO:0060136)3.03209707
45positive regulation of hormone biosynthetic process (GO:0046886)3.01900280
46regulation of histone H3-K9 methylation (GO:0051570)3.01590112
47DNA geometric change (GO:0032392)2.98999055
48prostate gland growth (GO:0060736)2.97885709
49poly(A)+ mRNA export from nucleus (GO:0016973)2.96288116
50mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.89921328
51mitotic sister chromatid segregation (GO:0000070)2.89260538
52histone methylation (GO:0016571)2.88882880
53histone deubiquitination (GO:0016578)2.88611953
54protein demethylation (GO:0006482)2.87916176
55protein dealkylation (GO:0008214)2.87916176
56positive regulation of cell cycle checkpoint (GO:1901978)2.87627034
57embryonic retina morphogenesis in camera-type eye (GO:0060059)2.87412802
58protein-DNA complex disassembly (GO:0032986)2.86251551
59nucleosome disassembly (GO:0006337)2.86251551
60nuclear envelope disassembly (GO:0051081)2.86057468
61membrane disassembly (GO:0030397)2.86057468
62regulation of DNA damage checkpoint (GO:2000001)2.85888275
63histone H3-K9 demethylation (GO:0033169)2.81751001
64paraxial mesoderm development (GO:0048339)2.81095913
65peptidyl-threonine phosphorylation (GO:0018107)2.80413368
66mitotic nuclear envelope disassembly (GO:0007077)2.80350006
67glial cell proliferation (GO:0014009)2.80185688
68protein export from nucleus (GO:0006611)2.74759529
69histone H4-K16 acetylation (GO:0043984)2.74361536
70pre-miRNA processing (GO:0031054)2.72799349
71negative regulation of histone modification (GO:0031057)2.69555173
72DNA conformation change (GO:0071103)2.68869068
73positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.68460043
74morphogenesis of an epithelial sheet (GO:0002011)2.68246484
75negative regulation of histone methylation (GO:0031061)2.67389413
76somite development (GO:0061053)2.66424411
77nucleus organization (GO:0006997)2.66385235
78regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.65879631
793-UTR-mediated mRNA stabilization (GO:0070935)2.64810063
80dopaminergic neuron differentiation (GO:0071542)2.63751716
81NLS-bearing protein import into nucleus (GO:0006607)2.63682239
82peptidyl-threonine modification (GO:0018210)2.62935997
83regulation of cardioblast proliferation (GO:0003264)2.62782461
84regulation of secondary heart field cardioblast proliferation (GO:0003266)2.62782461
85negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.62598327
86regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.62559143
87prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.61926800
88mRNA transport (GO:0051028)2.61709940
89anatomical structure arrangement (GO:0048532)2.60971337
90positive regulation by host of viral transcription (GO:0043923)2.60073280
91regulation of non-canonical Wnt signaling pathway (GO:2000050)2.59326526
92phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.58555606
93embryonic camera-type eye morphogenesis (GO:0048596)2.56647137
94positive regulation of histone deacetylation (GO:0031065)2.55373243
95positive regulation of DNA-templated transcription, initiation (GO:2000144)2.54870458
96regulation of sister chromatid cohesion (GO:0007063)2.54354485
97establishment of spindle orientation (GO:0051294)2.53431097
98N-terminal protein amino acid acetylation (GO:0006474)2.53336499
99proximal/distal pattern formation (GO:0009954)2.52889947
100spliceosomal tri-snRNP complex assembly (GO:0000244)2.52104977
101layer formation in cerebral cortex (GO:0021819)2.51787656
102hippo signaling (GO:0035329)2.51508596
103nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.51488714
104DNA synthesis involved in DNA repair (GO:0000731)2.50315545
105heart morphogenesis (GO:0003007)2.49953082
106histone H4 deacetylation (GO:0070933)2.49637567
107mRNA splice site selection (GO:0006376)2.49537420
108negative regulation of chromatin modification (GO:1903309)2.48347791
109planar cell polarity pathway involved in neural tube closure (GO:0090179)2.48313505
110genitalia morphogenesis (GO:0035112)2.48144960
111positive regulation of histone methylation (GO:0031062)2.46830291
112hematopoietic stem cell differentiation (GO:0060218)2.46772056
113negative regulation of gene expression, epigenetic (GO:0045814)2.46685659
114positive regulation of fatty acid beta-oxidation (GO:0032000)2.45040191
115protein localization to chromosome, centromeric region (GO:0071459)2.44652229
116positive regulation of glycogen biosynthetic process (GO:0045725)2.44425484
117branching involved in prostate gland morphogenesis (GO:0060442)2.43964633
118coronary vasculature morphogenesis (GO:0060977)2.42712209
119histone H2B ubiquitination (GO:0033523)2.42436232
120histone lysine demethylation (GO:0070076)2.42348469
121protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.41548396
122sister chromatid cohesion (GO:0007062)2.41377804
123positive regulation of granulocyte differentiation (GO:0030854)2.39735206
124negative regulation of histone acetylation (GO:0035067)2.38870372
125positive regulation of dendritic spine morphogenesis (GO:0061003)2.38563941
126peptidyl-tyrosine autophosphorylation (GO:0038083)2.37975703
127histone H3-K4 methylation (GO:0051568)2.37106085
128regulation of glucose import in response to insulin stimulus (GO:2001273)2.36857695
129atrial septum morphogenesis (GO:0060413)2.36362330
130positive regulation of hormone metabolic process (GO:0032352)2.35709259
131negative regulation of DNA repair (GO:0045738)2.34681011
132lateral sprouting from an epithelium (GO:0060601)2.33810450
133retrograde transport, vesicle recycling within Golgi (GO:0000301)2.33148824
134regulation of axon extension involved in axon guidance (GO:0048841)2.33031690
135negative regulation of cell size (GO:0045792)2.32951603
136Golgi transport vesicle coating (GO:0048200)2.31933307
137COPI coating of Golgi vesicle (GO:0048205)2.31933307
138nuclear pore complex assembly (GO:0051292)2.31156975
139embryonic foregut morphogenesis (GO:0048617)2.30242314
140regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.30213123
141endocardial cushion development (GO:0003197)2.29833412
142peptidyl-lysine dimethylation (GO:0018027)2.28367865
143response to epidermal growth factor (GO:0070849)2.27573828
144regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.27504124
145regulation of RNA export from nucleus (GO:0046831)2.27067712
146negative regulation of axon extension involved in axon guidance (GO:0048843)2.26604669
147definitive hemopoiesis (GO:0060216)2.26419734
148positive regulation of mRNA catabolic process (GO:0061014)2.26222394
149outer ear morphogenesis (GO:0042473)2.25819776
150protein localization to endosome (GO:0036010)2.25756952
151establishment of protein localization to Golgi (GO:0072600)2.25675623
152negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.24998276
153negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.23239822
154negative regulation of translation, ncRNA-mediated (GO:0040033)2.23239822
155regulation of translation, ncRNA-mediated (GO:0045974)2.23239822
156peptidyl-lysine trimethylation (GO:0018023)2.21731993
157dendritic spine morphogenesis (GO:0060997)2.21552194
158protein targeting to Golgi (GO:0000042)2.20853777
159COPII vesicle coating (GO:0048208)2.19110775
160germ cell migration (GO:0008354)2.18970731
161regulation of heart morphogenesis (GO:2000826)2.18021674
162negative regulation of circadian rhythm (GO:0042754)2.16274924
163positive regulation of glycolytic process (GO:0045821)2.15887050
164peptidyl-lysine methylation (GO:0018022)2.15643292
165regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.15013410
166positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.15013410
167regulation of DNA endoreduplication (GO:0032875)2.15012943
168cochlea morphogenesis (GO:0090103)2.13526118
169locomotory exploration behavior (GO:0035641)2.13122560
170type B pancreatic cell development (GO:0003323)2.12251828
171neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.11387122
172cerebellar Purkinje cell differentiation (GO:0021702)2.11114955

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.09397333
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.57010962
3STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.70167079
4E2F4_17652178_ChIP-ChIP_JURKAT_Human2.68229309
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.67193274
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.65961597
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.54157894
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.49011967
9HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.26837493
10TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.25814545
11DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.25295226
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.24139609
13ZNF217_24962896_ChIP-Seq_MCF-7_Human2.08637515
14GBX2_23144817_ChIP-Seq_PC3_Human2.07949827
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.07918112
16GATA1_22025678_ChIP-Seq_K562_Human2.07311168
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.03416342
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.02893853
19WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.00857397
20CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.99613766
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.97170741
22ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.92345783
23TCF4_18268006_ChIP-ChIP_LS174T_Human1.92317785
24KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.89989578
25FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.88845960
26YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86590237
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.78801616
28CIITA_25753668_ChIP-Seq_RAJI_Human1.78732177
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77971767
30E2F1_21310950_ChIP-Seq_MCF-7_Human1.73311820
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.70551893
32SALL4_18804426_ChIP-ChIP_XEN_Mouse1.69567296
33EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.68293406
34CLOCK_20551151_ChIP-Seq_293T_Human1.68038322
35WT1_19549856_ChIP-ChIP_CCG9911_Human1.66549242
36TP63_19390658_ChIP-ChIP_HaCaT_Human1.66090740
37CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.64713415
38PKCTHETA_26484144_Chip-Seq_BREAST_Human1.63107943
39CTNNB1_20460455_ChIP-Seq_HCT116_Human1.58864395
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57092980
41PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.56180551
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54301129
43TP53_16413492_ChIP-PET_HCT116_Human1.53814649
44KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.53281091
45FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.52567511
46ISL1_27105846_Chip-Seq_CPCs_Mouse1.52007188
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47305319
48WT1_25993318_ChIP-Seq_PODOCYTE_Human1.47292278
49AR_21572438_ChIP-Seq_LNCaP_Human1.45836166
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.44429347
51YAP1_20516196_ChIP-Seq_MESCs_Mouse1.44158898
52EP300_21415370_ChIP-Seq_HL-1_Mouse1.43457929
53SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.42649728
54EZH2_18974828_ChIP-Seq_MESCs_Mouse1.42391051
55RNF2_18974828_ChIP-Seq_MESCs_Mouse1.42391051
56TAF15_26573619_Chip-Seq_HEK293_Human1.40922887
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40293848
58ARNT_22903824_ChIP-Seq_MCF-7_Human1.38461986
59SMAD4_21799915_ChIP-Seq_A2780_Human1.37891097
60BCAT_22108803_ChIP-Seq_LS180_Human1.37881753
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.37360295
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.35736828
63JARID2_20064375_ChIP-Seq_MESCs_Mouse1.35216276
64EGR1_19374776_ChIP-ChIP_THP-1_Human1.34459246
65KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.34047601
66KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.34047601
67KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.34047601
68AR_21909140_ChIP-Seq_LNCAP_Human1.33106585
69ZFP281_27345836_Chip-Seq_ESCs_Mouse1.32963178
70ESR1_20079471_ChIP-ChIP_T-47D_Human1.32712791
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31472968
72SOX2_21211035_ChIP-Seq_LN229_Gbm1.31422716
73TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.30605793
74FUS_26573619_Chip-Seq_HEK293_Human1.30363568
75SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.29248587
76NCOR1_26117541_ChIP-Seq_K562_Human1.29052191
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27899858
78AR_19668381_ChIP-Seq_PC3_Human1.27876417
79SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.27731181
80EZH2_22144423_ChIP-Seq_EOC_Human1.27730477
81TBX3_20139965_ChIP-Seq_MESCs_Mouse1.26090202
82TBX3_20139965_ChIP-Seq_ESCs_Mouse1.25814178
83STAT3_23295773_ChIP-Seq_U87_Human1.24627023
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21319579
85EWS_26573619_Chip-Seq_HEK293_Human1.20954897
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.20795392
87STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.20156820
88TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19854173
89MYC_22102868_ChIP-Seq_BL_Human1.19342984
90CHD1_26751641_Chip-Seq_LNCaP_Human1.18885771
91NANOG_21062744_ChIP-ChIP_HESCs_Human1.18819458
92BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18219397
93RNF2_27304074_Chip-Seq_ESCs_Mouse1.18012519
94BRD4_25478319_ChIP-Seq_HGPS_Human1.17711066
95DROSHA_22980978_ChIP-Seq_HELA_Human1.17099792
96MYCN_18555785_ChIP-Seq_MESCs_Mouse1.15790493
97AHR_22903824_ChIP-Seq_MCF-7_Human1.14959014
98FOXM1_26456572_ChIP-Seq_MCF-7_Human1.14509052
99BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14404535
100RING1B_27294783_Chip-Seq_NPCs_Mouse1.13688874
101EED_16625203_ChIP-ChIP_MESCs_Mouse1.13121754
102SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.12906173
103KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12835045
104SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.12309100
105JARID2_20075857_ChIP-Seq_MESCs_Mouse1.12088249
106EZH2_27304074_Chip-Seq_ESCs_Mouse1.10302964
107IGF1R_20145208_ChIP-Seq_DFB_Human1.10134992
108FOXA2_19822575_ChIP-Seq_HepG2_Human1.09895492
109GATA1_19941826_ChIP-Seq_K562_Human1.09851194
110NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09659119
111SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.09650832
112PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08697646
113P300_19829295_ChIP-Seq_ESCs_Human1.08334176
114FOXM1_23109430_ChIP-Seq_U2OS_Human1.08100687
115ZNF274_21170338_ChIP-Seq_K562_Hela1.07354949
116TCF7_22412390_ChIP-Seq_EML_Mouse1.05829651
117CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05290611
118FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.05259001
119KDM2B_26808549_Chip-Seq_JURKAT_Human1.04923225
120TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04555227
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04555227
122CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04508380
123CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.04143686
124SMAD_19615063_ChIP-ChIP_OVARY_Human1.02821263
125ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02801437
126RXR_22108803_ChIP-Seq_LS180_Human1.02459408
127ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02455578
128RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.02173944
129SOX9_26525672_Chip-Seq_HEART_Mouse1.02014515
130GATA2_19941826_ChIP-Seq_K562_Human1.01696610
131TCF4_23295773_ChIP-Seq_U87_Human1.01285563
132EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00927795
133SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00531967
134MYB_26560356_Chip-Seq_TH1_Human0.97576055
135KDM5A_27292631_Chip-Seq_BREAST_Human0.95570888
136PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93317283
137TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89625276
138FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.89199707
139STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.88025680
140SCL_19346495_ChIP-Seq_HPC-7_Human0.87841210
141FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.87603173
142POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.87531338
143GATA4_21415370_ChIP-Seq_HL-1_Mouse0.86898979
144MYB_26560356_Chip-Seq_TH2_Human0.86692089
145CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.86069195
146NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.84147629
147KDM2B_26808549_Chip-Seq_DND41_Human0.81883497
148STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.80093666
149KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.78282813
150FOXO3_23340844_ChIP-Seq_DLD1_Human0.77186377
151P300_27058665_Chip-Seq_ZR-75-30cells_Human0.76966351

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.22764349
2MP0010234_abnormal_vibrissa_follicle4.25291472
3MP0002877_abnormal_melanocyte_morpholog3.08182802
4MP0000569_abnormal_digit_pigmentation3.05374568
5MP0002396_abnormal_hematopoietic_system2.81348593
6MP0005187_abnormal_penis_morphology2.81242564
7MP0000566_synostosis2.58671455
8MP0000537_abnormal_urethra_morphology2.46429672
9MP0010352_gastrointestinal_tract_polyps2.46294065
10MP0003787_abnormal_imprinting2.35225038
11MP0003111_abnormal_nucleus_morphology2.19303973
12MP0009780_abnormal_chondrocyte_physiolo2.10967253
13MP0003984_embryonic_growth_retardation2.02332635
14MP0002928_abnormal_bile_duct2.01408857
15MP0002088_abnormal_embryonic_growth/wei1.95199202
16MP0003077_abnormal_cell_cycle1.95002022
17MP0010094_abnormal_chromosome_stability1.93427016
18MP0003121_genomic_imprinting1.92463643
19MP0003300_gastrointestinal_ulcer1.90312840
20MP0006072_abnormal_retinal_apoptosis1.87431428
21MP0001672_abnormal_embryogenesis/_devel1.87241698
22MP0005380_embryogenesis_phenotype1.87241698
23MP0001299_abnormal_eye_distance/1.83531264
24MP0008007_abnormal_cellular_replicative1.79943082
25MP0001346_abnormal_lacrimal_gland1.79692300
26MP0000516_abnormal_urinary_system1.77000094
27MP0005367_renal/urinary_system_phenotyp1.77000094
28MP0003656_abnormal_erythrocyte_physiolo1.76689112
29MP0003122_maternal_imprinting1.74667707
30MP0001730_embryonic_growth_arrest1.71035696
31MP0003705_abnormal_hypodermis_morpholog1.70289012
32MP0001915_intracranial_hemorrhage1.69226373
33MP0003942_abnormal_urinary_system1.66966381
34MP0003252_abnormal_bile_duct1.66641447
35MP0002086_abnormal_extraembryonic_tissu1.64613398
36MP0005409_darkened_coat_color1.63319869
37MP0010307_abnormal_tumor_latency1.62669918
38MP0000350_abnormal_cell_proliferation1.62603112
39MP0003943_abnormal_hepatobiliary_system1.62402029
40MP0000428_abnormal_craniofacial_morphol1.61847124
41MP0010678_abnormal_skin_adnexa1.60516028
42MP0003183_abnormal_peptide_metabolism1.60055487
43MP0008789_abnormal_olfactory_epithelium1.58230382
44MP0005248_abnormal_Harderian_gland1.56738267
45MP0000427_abnormal_hair_cycle1.56189069
46MP0003567_abnormal_fetal_cardiomyocyte1.54897276
47MP0005503_abnormal_tendon_morphology1.52207230
48MP0002009_preneoplasia1.51948633
49MP0001697_abnormal_embryo_size1.50778115
50MP0002249_abnormal_larynx_morphology1.48552622
51MP0009053_abnormal_anal_canal1.44510787
52MP0010030_abnormal_orbit_morphology1.39315369
53MP0004264_abnormal_extraembryonic_tissu1.39178627
54MP0004885_abnormal_endolymph1.39127674
55MP0002938_white_spotting1.38490949
56MP0004957_abnormal_blastocyst_morpholog1.37974064
57MP0004197_abnormal_fetal_growth/weight/1.35040883
58MP0009703_decreased_birth_body1.33590687
59MP0003935_abnormal_craniofacial_develop1.33143751
60MP0003221_abnormal_cardiomyocyte_apopto1.31410504
61MP0002085_abnormal_embryonic_tissue1.30838247
62MP0003385_abnormal_body_wall1.30551225
63MP0004233_abnormal_muscle_weight1.30510142
64MP0002166_altered_tumor_susceptibility1.29412350
65MP0003123_paternal_imprinting1.29403427
66MP0002080_prenatal_lethality1.29063240
67MP0002233_abnormal_nose_morphology1.28349025
68MP0005397_hematopoietic_system_phenotyp1.27090791
69MP0001545_abnormal_hematopoietic_system1.27090791
70MP0005394_taste/olfaction_phenotype1.25804131
71MP0005499_abnormal_olfactory_system1.25804131
72MP0009384_cardiac_valve_regurgitation1.25372412
73MP0009697_abnormal_copulation1.24491917
74MP0010368_abnormal_lymphatic_system1.23478769
75MP0003890_abnormal_embryonic-extraembry1.22898900
76MP0003045_fibrosis1.22464308
77MP0008058_abnormal_DNA_repair1.19554995
78MP0003937_abnormal_limbs/digits/tail_de1.18645996
79MP0005171_absent_coat_pigmentation1.18269182
80MP0009278_abnormal_bone_marrow1.15804540
81MP0004859_abnormal_synaptic_plasticity1.14045183
82MP0002932_abnormal_joint_morphology1.13248120
83MP0002177_abnormal_outer_ear1.12179613
84MP0005220_abnormal_exocrine_pancreas1.10396928
85MP0002896_abnormal_bone_mineralization1.10296474
86MP0004272_abnormal_basement_membrane1.09118384
87MP0001286_abnormal_eye_development1.08735921
88MP0008932_abnormal_embryonic_tissue1.07725497
89MP0001270_distended_abdomen1.07630701
90MP0003091_abnormal_cell_migration1.06725556
91MP0001944_abnormal_pancreas_morphology1.05723070
92MP0002114_abnormal_axial_skeleton1.05601512
93MP0000703_abnormal_thymus_morphology1.05390030
94MP0009672_abnormal_birth_weight1.04786027
95MP0000631_abnormal_neuroendocrine_gland1.04561038
96MP0005621_abnormal_cell_physiology1.01820042
97MP0003115_abnormal_respiratory_system1.01386841
98MP0003755_abnormal_palate_morphology1.01368000
99MP0003763_abnormal_thymus_physiology0.99772645
100MP0002909_abnormal_adrenal_gland0.98745121
101MP0005379_endocrine/exocrine_gland_phen0.98597144
102MP0009115_abnormal_fat_cell0.98484712
103MP0000266_abnormal_heart_morphology0.97404627
104MP0000534_abnormal_ureter_morphology0.97179949
105MP0002116_abnormal_craniofacial_bone0.96760787
106MP0001661_extended_life_span0.96489740
107MP0000778_abnormal_nervous_system0.96238532
108MP0002084_abnormal_developmental_patter0.95992463
109MP0002697_abnormal_eye_size0.93985346
110MP0009250_abnormal_appendicular_skeleto0.93338041
111MP0000383_abnormal_hair_follicle0.93297825
112MP0000579_abnormal_nail_morphology0.92249108
113MP0001879_abnormal_lymphatic_vessel0.91021946
114MP0000049_abnormal_middle_ear0.89646532
115MP0002109_abnormal_limb_morphology0.89000912
116MP0001324_abnormal_eye_pigmentation0.88683332
117MP0006054_spinal_hemorrhage0.88629354
118MP0002108_abnormal_muscle_morphology0.86345029
119MP0000313_abnormal_cell_death0.85567952
120MP0002081_perinatal_lethality0.84058617
121MP0003868_abnormal_feces_composition0.84051256
122MP0008438_abnormal_cutaneous_collagen0.83986080
123MP0003119_abnormal_digestive_system0.83597640
124MP0004084_abnormal_cardiac_muscle0.82101965
125MP0005384_cellular_phenotype0.82072868
126MP0002092_abnormal_eye_morphology0.81550537
127MP0002234_abnormal_pharynx_morphology0.80455461
128MP0006138_congestive_heart_failure0.80283526
129MP0002128_abnormal_blood_circulation0.79408715
130MP0000432_abnormal_head_morphology0.79269082
131MP0002925_abnormal_cardiovascular_devel0.78753691
132MP0001293_anophthalmia0.78634527
133MP0005666_abnormal_adipose_tissue0.78574829
134MP0001784_abnormal_fluid_regulation0.78174186
135MP0000003_abnormal_adipose_tissue0.77814693
136MP0002269_muscular_atrophy0.77302169
137MP0010630_abnormal_cardiac_muscle0.76227497
138MP0004134_abnormal_chest_morphology0.76048340
139MP0000733_abnormal_muscle_development0.75592887
140MP0008961_abnormal_basal_metabolism0.75584099
141MP0004808_abnormal_hematopoietic_stem0.75520885
142MP0008995_early_reproductive_senescence0.74882093
143MP0004087_abnormal_muscle_fiber0.74746930
144MP0002282_abnormal_trachea_morphology0.73456242
145MP0002098_abnormal_vibrissa_morphology0.73250058
146MP0004811_abnormal_neuron_physiology0.72667054
147MP0004185_abnormal_adipocyte_glucose0.72546321
148MP0005623_abnormal_meninges_morphology0.72462645
149MP0005076_abnormal_cell_differentiation0.71634460
150MP0003861_abnormal_nervous_system0.70988722

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.80754625
2Macroorchidism (HP:0000053)3.76021342
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.62855849
4Short 4th metacarpal (HP:0010044)3.62855849
5Asymmetry of the thorax (HP:0001555)3.46831592
6Heterotopia (HP:0002282)3.33933651
7Papillary thyroid carcinoma (HP:0002895)3.32340651
8Acute myeloid leukemia (HP:0004808)3.25611626
9Hypoplastic labia majora (HP:0000059)3.03317710
10Neoplasm of the adrenal cortex (HP:0100641)2.98799896
11Broad palm (HP:0001169)2.88162734
12Abnormality of the 4th metacarpal (HP:0010012)2.87369038
13Abnormality of the labia majora (HP:0012881)2.85783746
14Enlarged penis (HP:0000040)2.85141456
15Exostoses (HP:0100777)2.77568370
16Ankyloglossia (HP:0010296)2.76516784
17Chorioretinal atrophy (HP:0000533)2.72861514
18Hepatoblastoma (HP:0002884)2.71625187
19Hypochromic microcytic anemia (HP:0004840)2.70209560
20Subacute progressive viral hepatitis (HP:0006572)2.62548861
21Overlapping toe (HP:0001845)2.59763412
22Lymphangioma (HP:0100764)2.57764545
23Hematochezia (HP:0002573)2.55084386
24Thyroid carcinoma (HP:0002890)2.52096085
25Cortical dysplasia (HP:0002539)2.51825402
26Acute lymphatic leukemia (HP:0006721)2.47226789
27Dysmetric saccades (HP:0000641)2.46590252
28Long eyelashes (HP:0000527)2.44701826
29Lip pit (HP:0100267)2.43144909
30Narrow palate (HP:0000189)2.42613392
31Abnormality of the fingertips (HP:0001211)2.42292851
32Aqueductal stenosis (HP:0002410)2.42132928
33Midline defect of the nose (HP:0004122)2.38346807
34Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.37136201
35Buphthalmos (HP:0000557)2.36547467
36Spinal cord lesions (HP:0100561)2.32502980
37Syringomyelia (HP:0003396)2.32502980
38Sandal gap (HP:0001852)2.32114051
39Insidious onset (HP:0003587)2.30199095
40Termporal pattern (HP:0011008)2.30199095
41Nephroblastoma (Wilms tumor) (HP:0002667)2.22093495
42Relative macrocephaly (HP:0004482)2.18521994
43Abnormality of the nasal septum (HP:0000419)2.16316281
44Smooth philtrum (HP:0000319)2.15811920
45Aortic aneurysm (HP:0004942)2.09574228
46Thick eyebrow (HP:0000574)2.08018053
47Embryonal renal neoplasm (HP:0011794)2.07664227
48Shallow orbits (HP:0000586)2.06713507
49Cystic hygroma (HP:0000476)2.05596099
50Vertebral arch anomaly (HP:0008438)2.02654288
51Abnormality of oral frenula (HP:0000190)2.01536015
52Morphological abnormality of the middle ear (HP:0008609)2.01534518
53Chromsome breakage (HP:0040012)2.00701520
54Broad thumb (HP:0011304)2.00585888
55Abnormality of the parietal bone (HP:0002696)2.00183201
56Acanthocytosis (HP:0001927)1.99842615
57Abnormality of chromosome segregation (HP:0002916)1.99273956
58Bowel incontinence (HP:0002607)1.97843611
59Obsessive-compulsive behavior (HP:0000722)1.97347069
60Hyperacusis (HP:0010780)1.94822634
61Truncal obesity (HP:0001956)1.94660819
62Colon cancer (HP:0003003)1.93284768
63Cutaneous melanoma (HP:0012056)1.92730920
64Disproportionate tall stature (HP:0001519)1.92347198
65Anterior segment dysgenesis (HP:0007700)1.92065771
66Limited elbow extension (HP:0001377)1.91737141
67Exotropia (HP:0000577)1.91578789
68Renal duplication (HP:0000075)1.90512057
69Megalencephaly (HP:0001355)1.90216474
70Absent frontal sinuses (HP:0002688)1.87974867
71Bowel diverticulosis (HP:0005222)1.87782633
72Increased nuchal translucency (HP:0010880)1.87364410
73Cutaneous finger syndactyly (HP:0010554)1.83708177
74Trigonocephaly (HP:0000243)1.82827935
75Hypoplasia of the maxilla (HP:0000327)1.82610776
76Anal stenosis (HP:0002025)1.82239084
77Abnormality of the epiphyses of the hand (HP:0005924)1.80370159
78Transitional cell carcinoma of the bladder (HP:0006740)1.78797661
79Neoplasm of the heart (HP:0100544)1.78633774
80Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.78113397
81Abnormality of the calcaneus (HP:0008364)1.77832528
82High anterior hairline (HP:0009890)1.76700835
83Abnormality of the radial head (HP:0003995)1.76625438
84Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.76277936
85Hyperthyroidism (HP:0000836)1.74855789
86Capillary hemangiomas (HP:0005306)1.74775703
87Abnormal large intestine physiology (HP:0012700)1.74256714
88Hypoplastic ischia (HP:0003175)1.74141975
89Bell-shaped thorax (HP:0001591)1.73008511
90Abnormality of the ischium (HP:0003174)1.72122728
91Gastrointestinal carcinoma (HP:0002672)1.71906946
92Malignant gastrointestinal tract tumors (HP:0006749)1.71906946
93Leiomyosarcoma (HP:0100243)1.71629803
94Uterine leiomyosarcoma (HP:0002891)1.71629803
95Abnormality of the intervertebral disk (HP:0005108)1.71619431
96Broad face (HP:0000283)1.71201631
97Submucous cleft hard palate (HP:0000176)1.70742159
98Hallux valgus (HP:0001822)1.70374687
99Renal hypoplasia (HP:0000089)1.69870697
100Deviation of the hallux (HP:0010051)1.69573922
101Cerebral aneurysm (HP:0004944)1.69523995
102Elfin facies (HP:0004428)1.69301158
103Chromosomal breakage induced by crosslinking agents (HP:0003221)1.69300991
104Heterochromia iridis (HP:0001100)1.69147788
105Abnormality of the distal phalanx of the thumb (HP:0009617)1.69050244
106Rhizomelia (HP:0008905)1.68879160
107Menstrual irregularities (HP:0000858)1.68378443
108Tapered finger (HP:0001182)1.68146088
109Intestinal malrotation (HP:0002566)1.67233856
110Hypopigmentation of the fundus (HP:0007894)1.65803690
111Synophrys (HP:0000664)1.64935716
112Fibrous tissue neoplasm (HP:0012316)1.64925700
113Labial hypoplasia (HP:0000066)1.64769445
114Supernumerary ribs (HP:0005815)1.64760069
115Low anterior hairline (HP:0000294)1.64705502
116Abnormality of the humeroradial joint (HP:0100744)1.64699264
117Missing ribs (HP:0000921)1.64107271
118Hammertoe (HP:0001765)1.63570411
119Renovascular hypertension (HP:0100817)1.63470377
120Diastasis recti (HP:0001540)1.63148828
121Viral hepatitis (HP:0006562)1.63132038
122Attention deficit hyperactivity disorder (HP:0007018)1.61782610
123Renal dysplasia (HP:0000110)1.61547119
124Abnormality of incisor morphology (HP:0011063)1.60977978
125Vascular tortuosity (HP:0004948)1.60603349
126Deeply set eye (HP:0000490)1.60395606
127Hyperglycemia (HP:0003074)1.60157707
128Abnormality of the left ventricular outflow tract (HP:0011103)1.59691912
129Subaortic stenosis (HP:0001682)1.59691912
130Astrocytoma (HP:0009592)1.59618566
131Abnormality of the astrocytes (HP:0100707)1.59618566
132Flat acetabular roof (HP:0003180)1.59332655
133Dislocated radial head (HP:0003083)1.59002811
134Bicuspid aortic valve (HP:0001647)1.58631546
135Urethral obstruction (HP:0000796)1.58280582
136Posterior subcapsular cataract (HP:0007787)1.57781409
137Large earlobe (HP:0009748)1.57445323
138Bladder neoplasm (HP:0009725)1.57231281
139Bladder carcinoma (HP:0002862)1.57231281
140Curly hair (HP:0002212)1.57200711
141Broad finger (HP:0001500)1.57197726
142Wide nose (HP:0000445)1.56707946
143Embryonal neoplasm (HP:0002898)1.56281304
144Cutis marmorata (HP:0000965)1.55424692
145Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.55190432
146Medulloblastoma (HP:0002885)1.55049781
147Cafe-au-lait spot (HP:0000957)1.55013572
148Excessive salivation (HP:0003781)1.54503586
149Drooling (HP:0002307)1.54503586
150Rectal prolapse (HP:0002035)1.53456123
151Reticulocytosis (HP:0001923)1.53417948
152Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.53153467
153Vitreoretinal degeneration (HP:0000655)1.53068684
154Poikilocytosis (HP:0004447)1.52954399
155Cubitus valgus (HP:0002967)1.52943432
156Broad phalanges of the hand (HP:0009768)1.52171508
157Deep philtrum (HP:0002002)1.52062445
1582-3 toe syndactyly (HP:0004691)1.51688024
159Pancreatic islet-cell hyperplasia (HP:0004510)1.51055863
160Mitral valve prolapse (HP:0001634)1.50123575
161Arterial tortuosity (HP:0005116)1.50106686
162Fibroma (HP:0010614)1.48950825

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR25.57435123
2FRK5.43629423
3LATS13.10971726
4ICK3.09039753
5FGFR32.76792066
6PDGFRA2.37794104
7TRIB32.35798366
8BRD42.03980556
9SIK12.01867481
10PTK61.83518069
11EEF2K1.80925169
12CDK121.79526492
13TGFBR11.66664688
14CAMK1G1.63034110
15INSRR1.62377966
16CAMK1D1.59882264
17MKNK21.59577852
18FGFR11.53821260
19PKN21.49474031
20KSR21.41786143
21CSNK1A1L1.34400148
22PRPF4B1.34053895
23FGFR41.32558391
24ERBB31.30908066
25NEK21.30366136
26RET1.29606869
27MAP3K41.27733951
28CDK61.27410086
29MKNK11.25945019
30FER1.20487678
31DDR21.20387226
32NTRK21.19564225
33SCYL21.17613802
34SIK21.17578250
35PNCK1.16147260
36TTK1.14887318
37BRSK21.14298373
38EIF2AK11.09802550
39PASK1.08793215
40YES11.06972418
41NTRK31.05125375
42NEK91.04704686
43CLK11.04648829
44NUAK11.04195895
45SGK21.03538478
46CDC71.03332785
47PDGFRB0.99001968
48SGK30.97677055
49HIPK20.95282181
50SRPK10.91222179
51PRKCH0.90575266
52PAK30.90430201
53NLK0.89294477
54MELK0.88647945
55MTOR0.88388910
56WNK10.87589452
57IRAK20.85342353
58MARK20.81828086
59CSNK1G20.81799735
60CDK90.81748906
61WEE10.81150245
62CDK40.80005879
63MAPK100.78710364
64DMPK0.77085595
65MAP2K70.76884135
66TTN0.75213739
67SMG10.75145494
68CSNK1G10.73657881
69RAF10.73066272
70EPHB20.71742782
71MAP3K20.71452895
72EPHA30.70767607
73ALK0.70262484
74CDC42BPA0.70224600
75PRKD30.69931398
76TYRO30.68998311
77TRPM70.68044589
78STK30.67828080
79MAP2K30.67061523
80DYRK1B0.66855167
81CSNK1G30.66511582
82RPS6KB20.66332925
83ERBB20.66255504
84PLK40.65953917
85CDK70.65840263
86MAP3K70.65589503
87LATS20.64655007
88TGFBR20.64032565
89MAP2K40.61296279
90ITK0.60517504
91ATR0.60449472
92PRKAA10.59961159
93RIPK40.59958709
94BCR0.58874887
95CDK30.58458885
96STK38L0.57901505
97RPS6KB10.57313612
98CHEK20.57189351
99PAK20.56435527
100PRKD10.56264762
101FLT30.54233646
102MAPK110.53590007
103KSR10.53298340
104PLK30.52661288
105NEK60.52160838
106MAP3K140.51250777
107ATM0.51069342
108CAMK40.50408436
109IGF1R0.48664729
110SGK2230.47937986
111SGK4940.47937986
112RIPK10.47699779
113PRKD20.45557943
114MAPK10.45405042
115EIF2AK30.45332246
116CHEK10.44597019
117SGK10.44213359
118AKT30.44179861
119DYRK1A0.44125086
120MAPK140.44087848
121LRRK20.43854008
122MARK30.43488951
123DYRK30.42427306
124SIK30.41995356
125DAPK20.41157235
126MAP3K60.40482641
127MAP3K100.40404852
128ILK0.39020304
129PRKDC0.38917631
130CSNK1D0.38728083
131GSK3B0.38282788
132CDK10.37582055
133RPS6KA20.36891263
134CDK20.36474993
135JAK10.35968482
136JAK20.35966336
137STK110.35399877
138CASK0.35299330
139AKT10.35212813
140MAPK70.35161477
141CSNK1E0.34785272
142EPHA40.34769500

Predicted pathways (KEGG)

RankGene SetZ-score
1Acute myeloid leukemia_Homo sapiens_hsa052211.98019677
2mRNA surveillance pathway_Homo sapiens_hsa030151.97981961
3Basal cell carcinoma_Homo sapiens_hsa052171.85208656
4Nitrogen metabolism_Homo sapiens_hsa009101.81162296
5Endometrial cancer_Homo sapiens_hsa052131.77857222
6Lysine degradation_Homo sapiens_hsa003101.74325812
7mTOR signaling pathway_Homo sapiens_hsa041501.60185932
8Glioma_Homo sapiens_hsa052141.57616792
9Proteoglycans in cancer_Homo sapiens_hsa052051.52640235
10Non-small cell lung cancer_Homo sapiens_hsa052231.49452854
11Renin secretion_Homo sapiens_hsa049241.44741515
12Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.43763431
13Insulin secretion_Homo sapiens_hsa049111.43272143
14Adherens junction_Homo sapiens_hsa045201.42500686
15Thyroid hormone signaling pathway_Homo sapiens_hsa049191.42460213
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.39171740
17Small cell lung cancer_Homo sapiens_hsa052221.35511295
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.35282351
19Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.33100127
20Type II diabetes mellitus_Homo sapiens_hsa049301.33081509
21Chronic myeloid leukemia_Homo sapiens_hsa052201.31747655
22Melanogenesis_Homo sapiens_hsa049161.29033069
23Hedgehog signaling pathway_Homo sapiens_hsa043401.28417925
24Wnt signaling pathway_Homo sapiens_hsa043101.27636936
25MicroRNAs in cancer_Homo sapiens_hsa052061.27140797
26Phosphatidylinositol signaling system_Homo sapiens_hsa040701.27006940
27Long-term potentiation_Homo sapiens_hsa047201.26729041
28B cell receptor signaling pathway_Homo sapiens_hsa046621.26684818
29Phototransduction_Homo sapiens_hsa047441.23779552
30Circadian entrainment_Homo sapiens_hsa047131.23609492
31Insulin resistance_Homo sapiens_hsa049311.23508601
32Prostate cancer_Homo sapiens_hsa052151.22582063
33Dorso-ventral axis formation_Homo sapiens_hsa043201.21465337
34Hippo signaling pathway_Homo sapiens_hsa043901.21336781
35RNA transport_Homo sapiens_hsa030131.19936637
36Colorectal cancer_Homo sapiens_hsa052101.17828360
37Hepatitis B_Homo sapiens_hsa051611.17775373
38Focal adhesion_Homo sapiens_hsa045101.16512497
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.13574372
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.12907743
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.12312840
42Non-homologous end-joining_Homo sapiens_hsa034501.09671363
43FoxO signaling pathway_Homo sapiens_hsa040681.08405651
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08154757
45Inositol phosphate metabolism_Homo sapiens_hsa005621.07232530
46Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05909282
47Neurotrophin signaling pathway_Homo sapiens_hsa047221.05217387
48ErbB signaling pathway_Homo sapiens_hsa040121.02591844
49Spliceosome_Homo sapiens_hsa030401.01420165
50Dopaminergic synapse_Homo sapiens_hsa047280.98114515
51cAMP signaling pathway_Homo sapiens_hsa040240.98068977
52Viral carcinogenesis_Homo sapiens_hsa052030.96827807
53Pancreatic cancer_Homo sapiens_hsa052120.96523366
54Prolactin signaling pathway_Homo sapiens_hsa049170.96334268
55Circadian rhythm_Homo sapiens_hsa047100.95674428
56VEGF signaling pathway_Homo sapiens_hsa043700.95629140
57Cholinergic synapse_Homo sapiens_hsa047250.95578403
58GABAergic synapse_Homo sapiens_hsa047270.93574372
59Estrogen signaling pathway_Homo sapiens_hsa049150.92065515
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.91881554
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91704684
62Thyroid hormone synthesis_Homo sapiens_hsa049180.90729091
63Glucagon signaling pathway_Homo sapiens_hsa049220.90263338
64Glutamatergic synapse_Homo sapiens_hsa047240.89529063
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89223067
66TGF-beta signaling pathway_Homo sapiens_hsa043500.88853056
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88050438
68Platelet activation_Homo sapiens_hsa046110.87919341
69T cell receptor signaling pathway_Homo sapiens_hsa046600.87287331
70Pathways in cancer_Homo sapiens_hsa052000.85528596
71ECM-receptor interaction_Homo sapiens_hsa045120.84708913
72Renal cell carcinoma_Homo sapiens_hsa052110.84476755
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83465476
74HIF-1 signaling pathway_Homo sapiens_hsa040660.83350159
75Thyroid cancer_Homo sapiens_hsa052160.83048674
76Gap junction_Homo sapiens_hsa045400.82605525
77Insulin signaling pathway_Homo sapiens_hsa049100.82234853
78Long-term depression_Homo sapiens_hsa047300.82055398
79Bladder cancer_Homo sapiens_hsa052190.81239849
80Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.80617393
81Olfactory transduction_Homo sapiens_hsa047400.80258949
82Melanoma_Homo sapiens_hsa052180.79442711
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79105665
84Salivary secretion_Homo sapiens_hsa049700.78755843
85Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.77660383
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76266210
87Axon guidance_Homo sapiens_hsa043600.76265656
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76062756
89Amphetamine addiction_Homo sapiens_hsa050310.75393246
90Fatty acid biosynthesis_Homo sapiens_hsa000610.75292717
91AMPK signaling pathway_Homo sapiens_hsa041520.75116610
92Rap1 signaling pathway_Homo sapiens_hsa040150.74987912
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74430055
94GnRH signaling pathway_Homo sapiens_hsa049120.74195755
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73933768
96Morphine addiction_Homo sapiens_hsa050320.73918993
97Oxytocin signaling pathway_Homo sapiens_hsa049210.73376082
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73254144
99p53 signaling pathway_Homo sapiens_hsa041150.72816126
100Dilated cardiomyopathy_Homo sapiens_hsa054140.72181516
101Choline metabolism in cancer_Homo sapiens_hsa052310.71575067
102Cocaine addiction_Homo sapiens_hsa050300.71538507
103Ovarian steroidogenesis_Homo sapiens_hsa049130.71141848
104HTLV-I infection_Homo sapiens_hsa051660.68760245
105Gastric acid secretion_Homo sapiens_hsa049710.68208382
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.67863810
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67312017
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67264027
109Measles_Homo sapiens_hsa051620.65916296
110MAPK signaling pathway_Homo sapiens_hsa040100.65664814
111Notch signaling pathway_Homo sapiens_hsa043300.64475743
112Fatty acid degradation_Homo sapiens_hsa000710.64331306
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.64229764
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63979435
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.62904487
116Oocyte meiosis_Homo sapiens_hsa041140.62843542
117Fatty acid metabolism_Homo sapiens_hsa012120.61901622
118Cell cycle_Homo sapiens_hsa041100.61287006
119Hepatitis C_Homo sapiens_hsa051600.59303480
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59040246
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57940471
122Fanconi anemia pathway_Homo sapiens_hsa034600.55731001
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.53108854
124Herpes simplex infection_Homo sapiens_hsa051680.49630896
125One carbon pool by folate_Homo sapiens_hsa006700.46685836
126Nucleotide excision repair_Homo sapiens_hsa034200.46459322
127Ras signaling pathway_Homo sapiens_hsa040140.46412113
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46283171
129Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41134466
130Apoptosis_Homo sapiens_hsa042100.40101485
131RNA degradation_Homo sapiens_hsa030180.39905524

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