ZKSCAN5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a zinc finger protein of the Kruppel family. The protein contains a SCAN box and a KRAB A domain and may be involved in transcriptional regulation. A similar protein in mouse is differentially expressed in spermatogenesis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)5.01778342
2hyperosmotic salinity response (GO:0042538)4.31425619
3positive regulation of macrophage activation (GO:0043032)4.17403932
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.06275902
5L-phenylalanine catabolic process (GO:0006559)4.06275902
6kynurenine metabolic process (GO:0070189)3.94731786
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.93682771
8L-phenylalanine metabolic process (GO:0006558)3.93682771
9aromatic amino acid family catabolic process (GO:0009074)3.89291999
10histone H2A monoubiquitination (GO:0035518)3.79704927
11glycine metabolic process (GO:0006544)3.79397119
12glyoxylate metabolic process (GO:0046487)3.78563185
13indole-containing compound catabolic process (GO:0042436)3.76654748
14indolalkylamine catabolic process (GO:0046218)3.76654748
15tryptophan catabolic process (GO:0006569)3.76654748
16mitotic sister chromatid cohesion (GO:0007064)3.76601860
17serine family amino acid catabolic process (GO:0009071)3.75737242
18nuclear pore complex assembly (GO:0051292)3.73870888
19tachykinin receptor signaling pathway (GO:0007217)3.68343631
20imidazole-containing compound metabolic process (GO:0052803)3.64493408
21cellular ketone body metabolic process (GO:0046950)3.60526475
22positive regulation of uterine smooth muscle contraction (GO:0070474)3.57440110
23cysteine metabolic process (GO:0006534)3.51269554
24lysine catabolic process (GO:0006554)3.50571556
25lysine metabolic process (GO:0006553)3.50571556
26folic acid-containing compound biosynthetic process (GO:0009396)3.48196202
27regulation of hippo signaling (GO:0035330)3.47596078
28homocysteine metabolic process (GO:0050667)3.47436680
29urea metabolic process (GO:0019627)3.46155294
30urea cycle (GO:0000050)3.46155294
31triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.44852707
32negative regulation of axon guidance (GO:1902668)3.41729799
33positive regulation of chemokine secretion (GO:0090197)3.41314354
34mitotic metaphase plate congression (GO:0007080)3.33802688
35serine family amino acid biosynthetic process (GO:0009070)3.33034981
36cellular response to cholesterol (GO:0071397)3.32928641
37positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.30972036
38positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.30972036
39positive regulation of mitotic sister chromatid separation (GO:1901970)3.30972036
40positive regulation of chromosome segregation (GO:0051984)3.29372751
41tryptophan metabolic process (GO:0006568)3.28307091
42regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.27749259
43paraxial mesoderm development (GO:0048339)3.26956739
44pre-miRNA processing (GO:0031054)3.26903900
45chromatin remodeling at centromere (GO:0031055)3.26886124
46serine family amino acid metabolic process (GO:0009069)3.26445570
47somatic hypermutation of immunoglobulin genes (GO:0016446)3.26431684
48somatic diversification of immune receptors via somatic mutation (GO:0002566)3.26431684
49positive regulation of fatty acid beta-oxidation (GO:0032000)3.25589841
50protein K6-linked ubiquitination (GO:0085020)3.24418248
51fatty acid homeostasis (GO:0055089)3.24202098
52alpha-linolenic acid metabolic process (GO:0036109)3.23095177
53cellular response to sterol (GO:0036315)3.22877198
54negative regulation of leukocyte chemotaxis (GO:0002689)3.22259869
55one-carbon metabolic process (GO:0006730)3.17073912
56DNA unwinding involved in DNA replication (GO:0006268)3.16388117
57CENP-A containing nucleosome assembly (GO:0034080)3.15682224
58replication fork processing (GO:0031297)3.14403016
59metaphase plate congression (GO:0051310)3.13972425
60DNA replication checkpoint (GO:0000076)3.10518562
61piRNA metabolic process (GO:0034587)3.09172569
62DNA replication-dependent nucleosome organization (GO:0034723)3.08487624
63DNA replication-dependent nucleosome assembly (GO:0006335)3.08487624
64negative regulation of macrophage differentiation (GO:0045650)3.07017378
65nitrogen cycle metabolic process (GO:0071941)3.05477505
66protein localization to chromosome, centromeric region (GO:0071459)3.05270443
67ketone body metabolic process (GO:1902224)3.03796642
68negative regulation of fibrinolysis (GO:0051918)3.03428698
69regulation of sister chromatid cohesion (GO:0007063)3.01418328
70DNA integration (GO:0015074)3.00023038
71meiotic chromosome segregation (GO:0045132)2.99465740
72negative regulation of histone methylation (GO:0031061)2.97618978
73negative regulation of DNA-dependent DNA replication (GO:2000104)2.95801977
74aspartate family amino acid catabolic process (GO:0009068)2.95614287
75regulation of spindle organization (GO:0090224)2.95535508
76attachment of spindle microtubules to kinetochore (GO:0008608)2.94811497
77sulfur amino acid catabolic process (GO:0000098)2.94415297
78bile acid biosynthetic process (GO:0006699)2.93650297
79regulation of DNA endoreduplication (GO:0032875)2.92769026
80acetyl-CoA metabolic process (GO:0006084)2.91764839
81alpha-amino acid catabolic process (GO:1901606)2.91023868
82fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.90712119
83high-density lipoprotein particle remodeling (GO:0034375)2.88170218
84pore complex assembly (GO:0046931)2.88074478
85male meiosis (GO:0007140)2.87834035
86regulation of translational fidelity (GO:0006450)2.87426270
87regulation of chemokine secretion (GO:0090196)2.86378517
88amino-acid betaine metabolic process (GO:0006577)2.84586934
89histone H2A ubiquitination (GO:0033522)2.84421847
90protein localization to kinetochore (GO:0034501)2.83457805
91regulation of centriole replication (GO:0046599)2.81236416
922-oxoglutarate metabolic process (GO:0006103)2.79344357
93histone H2A acetylation (GO:0043968)2.79156165
94regulation of centrosome cycle (GO:0046605)2.78329103
95regulation of fibrinolysis (GO:0051917)2.77268391
96histone exchange (GO:0043486)2.76747370
97artery development (GO:0060840)2.75761503
98peptidyl-lysine dimethylation (GO:0018027)2.75692229
99regulation of mitotic spindle organization (GO:0060236)2.75381561
100negative regulation of axon extension involved in axon guidance (GO:0048843)2.74846162
101regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.74694333
102regulation of nuclear cell cycle DNA replication (GO:0033262)2.72958951
103aromatic amino acid family metabolic process (GO:0009072)2.70844927
104retinal ganglion cell axon guidance (GO:0031290)2.69592033
105recombinational repair (GO:0000725)2.69553139
106L-serine metabolic process (GO:0006563)2.68630663
107regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.68172149
108regulation of mitotic spindle checkpoint (GO:1903504)2.68172149
109cellular amino acid catabolic process (GO:0009063)2.67811757
110ethanol oxidation (GO:0006069)2.67759955
111tetrahydrofolate metabolic process (GO:0046653)2.67569764
112regulation of posttranscriptional gene silencing (GO:0060147)2.67564700
113regulation of gene silencing by miRNA (GO:0060964)2.67564700
114regulation of gene silencing by RNA (GO:0060966)2.67564700
115double-strand break repair via homologous recombination (GO:0000724)2.67222706
116regulation of protein activation cascade (GO:2000257)2.67045359
117regulation of fatty acid beta-oxidation (GO:0031998)2.66613423
118negative regulation of fatty acid biosynthetic process (GO:0045717)2.66507375
119regulation of mitotic metaphase/anaphase transition (GO:0030071)2.65527120
120regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.65527120
121maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.65471952
122regulation of histone H3-K9 methylation (GO:0051570)2.65471328
123regulation of sister chromatid segregation (GO:0033045)2.65068511
124regulation of mitotic sister chromatid separation (GO:0010965)2.65068511
125regulation of mitotic sister chromatid segregation (GO:0033047)2.65068511
126cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.63869288
127protein localization to chromosome (GO:0034502)2.63837351
128ncRNA catabolic process (GO:0034661)2.63647663
129centriole replication (GO:0007099)2.63309860
130nuclear pore organization (GO:0006999)2.63281558
131regulation of triglyceride catabolic process (GO:0010896)2.62946094
132behavioral response to nicotine (GO:0035095)2.62869831
133synapsis (GO:0007129)2.61582765
134mitotic chromosome condensation (GO:0007076)2.61544640
135acylglycerol homeostasis (GO:0055090)2.61501393
136triglyceride homeostasis (GO:0070328)2.61501393
137complement activation, alternative pathway (GO:0006957)2.61018764
138rRNA catabolic process (GO:0016075)2.60816924
139nucleobase biosynthetic process (GO:0046112)2.60452033
140DNA double-strand break processing (GO:0000729)2.59831471
141negative regulation of sterol transport (GO:0032372)2.59417983
142negative regulation of cholesterol transport (GO:0032375)2.59417983
143translesion synthesis (GO:0019985)2.56959776
144bile acid metabolic process (GO:0008206)2.56950133
145reverse cholesterol transport (GO:0043691)2.56917316
146binding of sperm to zona pellucida (GO:0007339)2.56735098
147behavioral response to ethanol (GO:0048149)2.56479338
148anterograde synaptic vesicle transport (GO:0048490)2.55963825
149C4-dicarboxylate transport (GO:0015740)2.55932959
150acrosome assembly (GO:0001675)2.55432417
151DNA replication-independent nucleosome organization (GO:0034724)2.54702016
152DNA replication-independent nucleosome assembly (GO:0006336)2.54702016
153regulation of centrosome duplication (GO:0010824)2.53881154
154DNA-dependent DNA replication (GO:0006261)2.53694990
155microtubule anchoring (GO:0034453)2.52889590
156male meiosis I (GO:0007141)2.52266815
157regulation of chromosome segregation (GO:0051983)2.52236132
158regulation of meiosis I (GO:0060631)2.50233644
159eyelid development in camera-type eye (GO:0061029)2.50227177
160sister chromatid segregation (GO:0000819)2.50115776
161spindle checkpoint (GO:0031577)2.49938989
162lung-associated mesenchyme development (GO:0060484)2.49526189
163mitotic sister chromatid segregation (GO:0000070)2.49412831
164organelle disassembly (GO:1903008)2.48712894
165retinal cone cell development (GO:0046549)2.48361579
166nonmotile primary cilium assembly (GO:0035058)2.47658506
167postreplication repair (GO:0006301)2.46972881
168sister chromatid cohesion (GO:0007062)2.46479794
169reciprocal meiotic recombination (GO:0007131)2.44954543
170reciprocal DNA recombination (GO:0035825)2.44954543
171mitotic spindle checkpoint (GO:0071174)2.41648781
172somite development (GO:0061053)2.41345025
173hindbrain development (GO:0030902)2.40670440
174histone H3-K9 methylation (GO:0051567)2.40213281
175ribonucleoprotein complex disassembly (GO:0032988)2.39638664
176G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.38650224
177negative regulation of mast cell activation (GO:0033004)2.35505919
178chromatin assembly (GO:0031497)2.35382059
179regulation of gonadotropin secretion (GO:0032276)2.34593908
180negative regulation of chromosome segregation (GO:0051985)2.33504845

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.59967588
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.07786036
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.61913686
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.11075756
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.45289553
6ZNF274_21170338_ChIP-Seq_K562_Hela3.17378387
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.12997857
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.98791273
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.94667171
10* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.88080265
11NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.77397673
12EGR1_23403033_ChIP-Seq_LIVER_Mouse2.71975502
13AR_21909140_ChIP-Seq_LNCAP_Human2.70914648
14LXR_22158963_ChIP-Seq_LIVER_Mouse2.68131342
15VDR_22108803_ChIP-Seq_LS180_Human2.55728300
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.51311657
17EWS_26573619_Chip-Seq_HEK293_Human2.49285800
18GBX2_23144817_ChIP-Seq_PC3_Human2.44458816
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.40438059
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.39080510
21* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.30376784
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.25836077
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.25770152
24MYC_18555785_ChIP-Seq_MESCs_Mouse2.24574201
25EZH2_22144423_ChIP-Seq_EOC_Human2.19925598
26ZFP57_27257070_Chip-Seq_ESCs_Mouse2.17688515
27STAT6_21828071_ChIP-Seq_BEAS2B_Human2.16058343
28NOTCH1_21737748_ChIP-Seq_TLL_Human2.15770022
29POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.14838040
30SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.13022894
31ELK1_19687146_ChIP-ChIP_HELA_Human2.09012937
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.07335002
33FUS_26573619_Chip-Seq_HEK293_Human2.06198472
34CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.02780827
35TAF15_26573619_Chip-Seq_HEK293_Human2.02705034
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00374322
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.97034759
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.93283003
39IGF1R_20145208_ChIP-Seq_DFB_Human1.91609043
40GATA1_26923725_Chip-Seq_HPCs_Mouse1.84370048
41EST1_17652178_ChIP-ChIP_JURKAT_Human1.82746321
42MYC_19079543_ChIP-ChIP_MESCs_Mouse1.82704523
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.81622041
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80381750
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75021069
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73341715
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.71458989
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.69205700
49EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.67725635
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.65582995
51P300_19829295_ChIP-Seq_ESCs_Human1.63668535
52NELFA_20434984_ChIP-Seq_ESCs_Mouse1.61736940
53FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.61199943
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.59330881
55NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.58035919
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58022964
57TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.55701181
58MYC_18358816_ChIP-ChIP_MESCs_Mouse1.53223112
59IRF1_19129219_ChIP-ChIP_H3396_Human1.52461891
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51987917
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.51653121
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.51069250
63* ER_23166858_ChIP-Seq_MCF-7_Human1.50657030
64TCF3_18692474_ChIP-Seq_MESCs_Mouse1.49050955
65TCF3_18692474_ChIP-Seq_MEFs_Mouse1.48916174
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48287379
67PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.46889856
68NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.44518936
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43179934
70STAT3_23295773_ChIP-Seq_U87_Human1.42912443
71* KDM5A_27292631_Chip-Seq_BREAST_Human1.42860066
72TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40126835
73SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.39790494
74ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39613698
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.39393822
76* VDR_23849224_ChIP-Seq_CD4+_Human1.38557824
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36755220
78BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.35194104
79HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.34780917
80SMAD4_21799915_ChIP-Seq_A2780_Human1.34277083
81FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34065481
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33743138
83SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.33390526
84POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32838721
85POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32696343
86ZNF263_19887448_ChIP-Seq_K562_Human1.31971947
87KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.31252890
88FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30910686
89STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29755648
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29657249
91MYC_18940864_ChIP-ChIP_HL60_Human1.29627795
92SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.28673603
93* NANOG_21062744_ChIP-ChIP_HESCs_Human1.27212597
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26086884
95TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25893059
96PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25578301
97NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.24554629
98POU5F1_16518401_ChIP-PET_MESCs_Mouse1.23110010
99* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.23002332
100PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22336399
101IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22159523
102CBP_20019798_ChIP-Seq_JUKART_Human1.22159523
103PIAS1_25552417_ChIP-Seq_VCAP_Human1.21014075
104UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19605476
105YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19408765
106DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18631764
107ZFX_18555785_ChIP-Seq_MESCs_Mouse1.18258801
108SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18154558
109CLOCK_20551151_ChIP-Seq_293T_Human1.17923437
110CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16932697
111SMAD3_21741376_ChIP-Seq_EPCs_Human1.16417233
112TCF4_23295773_ChIP-Seq_U87_Human1.15528803
113SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.14650084
114PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14627449
115CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14512162
116E2F1_18555785_ChIP-Seq_MESCs_Mouse1.12668121
117XRN2_22483619_ChIP-Seq_HELA_Human1.12504970
118CBX2_27304074_Chip-Seq_ESCs_Mouse1.10667308
119* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09692062
120CIITA_25753668_ChIP-Seq_RAJI_Human1.09619256
121TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07308453
122EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06410297
123KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05611274
124NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05450169
125TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05377568
126SOX2_18692474_ChIP-Seq_MESCs_Mouse1.04506016
127RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04136746
128FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.03785472
129SOX9_26525672_Chip-Seq_HEART_Mouse1.03704962
130ETS1_20019798_ChIP-Seq_JURKAT_Human1.03434036
131PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03370036
132NANOG_18555785_Chip-Seq_ESCs_Mouse1.02313302
133HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02220781
134CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01903534
135POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.01430538
136AR_25329375_ChIP-Seq_VCAP_Human1.00782566
137TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00562963
138YY1_21170310_ChIP-Seq_MESCs_Mouse1.00299301
139KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00285694
140SOX2_16153702_ChIP-ChIP_HESCs_Human1.00237508
141TP63_19390658_ChIP-ChIP_HaCaT_Human0.99669817
142NANOG_18692474_ChIP-Seq_MEFs_Mouse0.98847652
143TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98753488
144POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98753488
145RUNX2_22187159_ChIP-Seq_PCA_Human0.97989392
146JUN_21703547_ChIP-Seq_K562_Human0.97424575
147TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97017415
148CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96865530
149FOXP3_21729870_ChIP-Seq_TREG_Human0.96634072
150MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96472865
151ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.96296781
152BCAT_22108803_ChIP-Seq_LS180_Human0.95971638
153* JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.94671474
154DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94289129
155NANOG_18692474_ChIP-Seq_MESCs_Mouse0.93606342
156ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92908059
157NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92745743
158GABP_19822575_ChIP-Seq_HepG2_Human0.92445435
159BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91140321
160GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90472676
161CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.89695927
162PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89378814
163TP53_22573176_ChIP-Seq_HFKS_Human0.89141061
164OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88831163
165TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.88086316
166CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87596612
167MYC_22102868_ChIP-Seq_BL_Human0.86227711
168SOX2_18692474_ChIP-Seq_MEFs_Mouse0.84934478
169KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.83812916
170KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.83812916
171KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.83812916
172NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.80706673

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.77622259
2MP0005360_urolithiasis4.52796994
3MP0003806_abnormal_nucleotide_metabolis3.92629410
4MP0005365_abnormal_bile_salt3.69077183
5MP0005085_abnormal_gallbladder_physiolo3.59588192
6MP0008057_abnormal_DNA_replication3.40182460
7MP0008877_abnormal_DNA_methylation3.05888628
8MP0006292_abnormal_olfactory_placode2.82036887
9MP0002102_abnormal_ear_morphology2.75571796
10MP0003136_yellow_coat_color2.57375714
11MP0010094_abnormal_chromosome_stability2.51665638
12MP0008875_abnormal_xenobiotic_pharmacok2.45405482
13MP0009840_abnormal_foam_cell2.38122177
14MP0010329_abnormal_lipoprotein_level2.35354246
15MP0003252_abnormal_bile_duct2.27572707
16MP0003111_abnormal_nucleus_morphology2.26557230
17MP0004957_abnormal_blastocyst_morpholog2.24821843
18MP0001293_anophthalmia2.23889739
19MP0005670_abnormal_white_adipose2.22714604
20MP0003283_abnormal_digestive_organ2.20425775
21MP0002234_abnormal_pharynx_morphology2.10480813
22MP0008058_abnormal_DNA_repair2.02141451
23MP0003315_abnormal_perineum_morphology1.98981054
24MP0004233_abnormal_muscle_weight1.91232032
25MP0003077_abnormal_cell_cycle1.87814807
26MP0003950_abnormal_plasma_membrane1.83571902
27MP0010352_gastrointestinal_tract_polyps1.80699673
28MP0002009_preneoplasia1.76034860
29MP0000569_abnormal_digit_pigmentation1.75121212
30MP0005551_abnormal_eye_electrophysiolog1.71576657
31MP0003705_abnormal_hypodermis_morpholog1.68622212
32MP0003787_abnormal_imprinting1.68134433
33MP0008789_abnormal_olfactory_epithelium1.65800949
34MP0003693_abnormal_embryo_hatching1.60335851
35MP0000778_abnormal_nervous_system1.58851532
36MP0003646_muscle_fatigue1.54010854
37MP0005666_abnormal_adipose_tissue1.53782329
38MP0005410_abnormal_fertilization1.50140283
39MP0001730_embryonic_growth_arrest1.48460320
40MP0005332_abnormal_amino_acid1.47805130
41MP0004133_heterotaxia1.46550060
42MP0002751_abnormal_autonomic_nervous1.46246525
43MP0009672_abnormal_birth_weight1.42012509
44MP0003011_delayed_dark_adaptation1.41203956
45MP0009046_muscle_twitch1.39064150
46MP0004185_abnormal_adipocyte_glucose1.37737862
47MP0003718_maternal_effect1.36900606
48MP0005171_absent_coat_pigmentation1.36505579
49MP0000647_abnormal_sebaceous_gland1.35684678
50MP0002233_abnormal_nose_morphology1.35379313
51MP0004084_abnormal_cardiac_muscle1.35098154
52MP0003755_abnormal_palate_morphology1.33432011
53MP0001299_abnormal_eye_distance/1.32940138
54MP0005391_vision/eye_phenotype1.32100565
55MP0001929_abnormal_gametogenesis1.31414087
56MP0005076_abnormal_cell_differentiation1.30835302
57MP0001286_abnormal_eye_development1.30316756
58MP0002938_white_spotting1.30184001
59MP0000609_abnormal_liver_physiology1.29147884
60MP0000049_abnormal_middle_ear1.28921050
61MP0005499_abnormal_olfactory_system1.27612813
62MP0005394_taste/olfaction_phenotype1.27612813
63MP0001915_intracranial_hemorrhage1.26991637
64MP0005380_embryogenesis_phenotype1.25446924
65MP0001672_abnormal_embryogenesis/_devel1.25446924
66MP0002092_abnormal_eye_morphology1.24653208
67MP0005266_abnormal_metabolism1.24281525
68MP0010030_abnormal_orbit_morphology1.22652537
69MP0000428_abnormal_craniofacial_morphol1.22610346
70MP0003984_embryonic_growth_retardation1.18932323
71MP0005451_abnormal_body_composition1.17701539
72MP0000631_abnormal_neuroendocrine_gland1.16110322
73MP0002088_abnormal_embryonic_growth/wei1.14992289
74MP0001529_abnormal_vocalization1.13621946
75MP0002653_abnormal_ependyma_morphology1.13371625
76MP0004197_abnormal_fetal_growth/weight/1.13057254
77MP0003941_abnormal_skin_development1.11721237
78MP0000534_abnormal_ureter_morphology1.11612060
79MP0003861_abnormal_nervous_system1.11097573
80MP0002085_abnormal_embryonic_tissue1.10812831
81MP0002210_abnormal_sex_determination1.10628616
82MP0002118_abnormal_lipid_homeostasis1.09266544
83MP0005187_abnormal_penis_morphology1.09121115
84MP0001697_abnormal_embryo_size1.08681649
85MP0003121_genomic_imprinting1.07613896
86MP0006072_abnormal_retinal_apoptosis1.06669676
87MP0003698_abnormal_male_reproductive1.06414857
88MP0003123_paternal_imprinting1.06183869
89MP0002638_abnormal_pupillary_reflex1.05801239
90MP0004264_abnormal_extraembryonic_tissu1.05454869
91MP0002837_dystrophic_cardiac_calcinosis1.05201240
92MP0002084_abnormal_developmental_patter1.04577540
93MP0008007_abnormal_cellular_replicative1.04478966
94MP0000350_abnormal_cell_proliferation1.04162878
95MP0002269_muscular_atrophy1.01932829
96MP0003935_abnormal_craniofacial_develop1.01680354
97MP0001324_abnormal_eye_pigmentation1.00835546
98MP0004134_abnormal_chest_morphology0.99399401
99MP0003385_abnormal_body_wall0.97057415
100MP0000955_abnormal_spinal_cord0.96034534
101MP0000383_abnormal_hair_follicle0.95845374
102MP0005319_abnormal_enzyme/_coenzyme0.95697717
103MP0005174_abnormal_tail_pigmentation0.94294784
104MP0002160_abnormal_reproductive_system0.94048043
105MP0002161_abnormal_fertility/fecundity0.93592601
106MP0003890_abnormal_embryonic-extraembry0.92438463
107MP0001666_abnormal_nutrient_absorption0.92266032
108MP0002086_abnormal_extraembryonic_tissu0.92120565
109MP0008961_abnormal_basal_metabolism0.91952220
110MP0000427_abnormal_hair_cycle0.91552972
111MP0001145_abnormal_male_reproductive0.91084356
112MP0001119_abnormal_female_reproductive0.90685120
113MP0000653_abnormal_sex_gland0.90218473
114MP0000598_abnormal_liver_morphology0.88122695
115MP0002098_abnormal_vibrissa_morphology0.88066843
116MP0002080_prenatal_lethality0.87944261
117MP0005253_abnormal_eye_physiology0.86661620
118MP0003115_abnormal_respiratory_system0.86633986
119MP0003191_abnormal_cellular_cholesterol0.86536196
120MP0005375_adipose_tissue_phenotype0.86135940
121MP0003868_abnormal_feces_composition0.85977046
122MP0002095_abnormal_skin_pigmentation0.85785929
123MP0002184_abnormal_innervation0.85763585
124MP0002752_abnormal_somatic_nervous0.84451205
125MP0006276_abnormal_autonomic_nervous0.84366795
126MP0004742_abnormal_vestibular_system0.83520137
127MP0009115_abnormal_fat_cell0.83504070
128MP0004036_abnormal_muscle_relaxation0.82596686
129MP0002127_abnormal_cardiovascular_syste0.82093652
130MP0004130_abnormal_muscle_cell0.81866888
131MP0009053_abnormal_anal_canal0.81772256
132MP0005248_abnormal_Harderian_gland0.81719974
133MP0003567_abnormal_fetal_cardiomyocyte0.81527411
134MP0006035_abnormal_mitochondrial_morpho0.80809902
135MP0009703_decreased_birth_body0.80784993
136MP0009745_abnormal_behavioral_response0.80180258
137MP0010307_abnormal_tumor_latency0.80112487
138MP0001984_abnormal_olfaction0.79328744
139MP0003699_abnormal_female_reproductive0.78143526
140MP0002152_abnormal_brain_morphology0.78010017
141MP0003938_abnormal_ear_development0.77958459
142MP0006036_abnormal_mitochondrial_physio0.77840992
143MP0005395_other_phenotype0.77314344
144MP0001346_abnormal_lacrimal_gland0.77249580
145MP0008932_abnormal_embryonic_tissue0.77232100
146MP0000372_irregular_coat_pigmentation0.76819582
147MP0003943_abnormal_hepatobiliary_system0.76712263
148MP0002177_abnormal_outer_ear0.75838102
149MP0003122_maternal_imprinting0.75685325
150MP0002697_abnormal_eye_size0.73011860
151MP0002111_abnormal_tail_morphology0.72660192
152MP0000751_myopathy0.72409336
153MP0003937_abnormal_limbs/digits/tail_de0.71052833
154MP0002970_abnormal_white_adipose0.70678554
155MP0005195_abnormal_posterior_eye0.70271602
156MP0002282_abnormal_trachea_morphology0.67949815
157MP0005083_abnormal_biliary_tract0.67785575
158MP0002971_abnormal_brown_adipose0.67757284
159MP0003119_abnormal_digestive_system0.65858372

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.01070558
2Deep venous thrombosis (HP:0002625)4.52762835
3Congenital stationary night blindness (HP:0007642)4.35604718
4Abnormality of monocarboxylic acid metabolism (HP:0010996)4.22136299
5Hyperglycinemia (HP:0002154)3.95456444
6Hypobetalipoproteinemia (HP:0003563)3.76551190
7Abnormality of aromatic amino acid family metabolism (HP:0004338)3.64057010
8Abnormality of sulfur amino acid metabolism (HP:0004339)3.47253072
9Ependymoma (HP:0002888)3.44577206
10Oligodactyly (hands) (HP:0001180)3.36336622
11Abnormality of pyrimidine metabolism (HP:0004353)3.20043834
12Ketosis (HP:0001946)3.16756465
13Hyperammonemia (HP:0001987)3.15849792
14Abnormality of midbrain morphology (HP:0002418)3.14549566
15Molar tooth sign on MRI (HP:0002419)3.14549566
16Abnormality of methionine metabolism (HP:0010901)3.12723908
17Hyperglycinuria (HP:0003108)3.12683753
18Abnormality of serine family amino acid metabolism (HP:0010894)3.11458474
19Abnormality of glycine metabolism (HP:0010895)3.11458474
20Astrocytoma (HP:0009592)3.10135702
21Abnormality of the astrocytes (HP:0100707)3.10135702
22Chromosomal breakage induced by crosslinking agents (HP:0003221)3.07667791
23Chromsome breakage (HP:0040012)3.06185551
24Pancreatic fibrosis (HP:0100732)3.03806872
25Xanthomatosis (HP:0000991)3.02355298
26Abnormality of chromosome segregation (HP:0002916)2.96445856
27Colon cancer (HP:0003003)2.96155887
28Abnormality of serum amino acid levels (HP:0003112)2.95171766
29Hypolipoproteinemia (HP:0010981)2.93754147
30Cone-rod dystrophy (HP:0000548)2.93572353
31Epidermoid cyst (HP:0200040)2.88407904
32Hypochromic microcytic anemia (HP:0004840)2.88373033
33Pancreatic cysts (HP:0001737)2.83351652
34Abnormality of aspartate family amino acid metabolism (HP:0010899)2.78821005
35Oligodactyly (HP:0012165)2.69228995
36Neoplasm of the adrenal cortex (HP:0100641)2.68986652
37Ketoacidosis (HP:0001993)2.68869497
38Volvulus (HP:0002580)2.66357564
39Hypoalphalipoproteinemia (HP:0003233)2.66304779
40Anophthalmia (HP:0000528)2.65887688
41Late onset (HP:0003584)2.62184763
42Impulsivity (HP:0100710)2.61878414
43Ectopic kidney (HP:0000086)2.59578738
44Nephronophthisis (HP:0000090)2.59043533
45Hypoglycemic coma (HP:0001325)2.58127528
46Abnormality of chromosome stability (HP:0003220)2.56644738
47Chronic hepatic failure (HP:0100626)2.55354166
48Protruding tongue (HP:0010808)2.54091034
49Upper motor neuron abnormality (HP:0002127)2.51152527
50Hyperlipoproteinemia (HP:0010980)2.50962290
51Abnormal gallbladder physiology (HP:0012438)2.50538182
52Cholecystitis (HP:0001082)2.50538182
53Prolonged partial thromboplastin time (HP:0003645)2.48489269
54Medial flaring of the eyebrow (HP:0010747)2.43903139
55Aplasia/Hypoplasia of the uvula (HP:0010293)2.43305869
56Oral leukoplakia (HP:0002745)2.42546072
57Retinal dysplasia (HP:0007973)2.42425078
58Meckel diverticulum (HP:0002245)2.41382685
59Abnormality of the lower motor neuron (HP:0002366)2.41298444
60Birth length less than 3rd percentile (HP:0003561)2.38672434
61Enlarged kidneys (HP:0000105)2.37973371
62Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.37777794
63Complement deficiency (HP:0004431)2.35634425
64Abnormality of the ileum (HP:0001549)2.34580542
65Abnormality of the renal medulla (HP:0100957)2.32689996
66Sex reversal (HP:0012245)2.31939014
67Abnormal sex determination (HP:0012244)2.31939014
68Supernumerary spleens (HP:0009799)2.29938198
69Abnormality of alanine metabolism (HP:0010916)2.26997525
70Hyperalaninemia (HP:0003348)2.26997525
71Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.26997525
72Patellar aplasia (HP:0006443)2.26814135
73Pigmentary retinal degeneration (HP:0001146)2.23870907
74Preaxial hand polydactyly (HP:0001177)2.23407462
75Type II lissencephaly (HP:0007260)2.21844043
76Cortical dysplasia (HP:0002539)2.19516848
77Drooling (HP:0002307)2.19033421
78Postaxial foot polydactyly (HP:0001830)2.18277919
79Medulloblastoma (HP:0002885)2.17346196
80Agnosia (HP:0010524)2.17203204
81Glioma (HP:0009733)2.16370801
82Gait imbalance (HP:0002141)2.16048133
83Spastic diplegia (HP:0001264)2.16038453
84Sloping forehead (HP:0000340)2.12527067
85Intestinal atresia (HP:0011100)2.12483450
86Abnormal biliary tract physiology (HP:0012439)2.11599483
87Bile duct proliferation (HP:0001408)2.11599483
88Abdominal situs inversus (HP:0003363)2.11166726
89Abnormality of abdominal situs (HP:0011620)2.11166726
90Small hand (HP:0200055)2.10672081
91Congenital primary aphakia (HP:0007707)2.10411260
92Preaxial foot polydactyly (HP:0001841)2.10371466
93Aplasia/Hypoplasia of the tongue (HP:0010295)2.10240145
94Abnormality of the intervertebral disk (HP:0005108)2.09796611
95Aplasia/Hypoplasia of the patella (HP:0006498)2.09096430
96Genital tract atresia (HP:0001827)2.07050940
97Lissencephaly (HP:0001339)2.06236881
98Limb hypertonia (HP:0002509)2.05245668
99Duodenal stenosis (HP:0100867)2.03975659
100Small intestinal stenosis (HP:0012848)2.03975659
101Biliary tract neoplasm (HP:0100574)2.03036312
102Pendular nystagmus (HP:0012043)2.01534042
103Abnormality of nucleobase metabolism (HP:0010932)2.00799404
104Delayed CNS myelination (HP:0002188)1.99943968
105Fat malabsorption (HP:0002630)1.99432022
106Shawl scrotum (HP:0000049)1.98908300
107Hypogonadotrophic hypogonadism (HP:0000044)1.98662694
108Male infertility (HP:0003251)1.97405644
109Abnormality of the duodenum (HP:0002246)1.97203041
110Poor coordination (HP:0002370)1.97155448
111High anterior hairline (HP:0009890)1.95347943
112Nephrogenic diabetes insipidus (HP:0009806)1.94557341
113Myoglobinuria (HP:0002913)1.93587897
114Dandy-Walker malformation (HP:0001305)1.92366354
115Abnormality of the common coagulation pathway (HP:0010990)1.91696125
116Rhabdomyosarcoma (HP:0002859)1.91589377
117Neoplasm of the oral cavity (HP:0100649)1.91150449
118Abnormality of the carotid arteries (HP:0005344)1.90879767
119Abnormality of the labia minora (HP:0012880)1.90019258
120Neonatal hypoglycemia (HP:0001998)1.89433161
121Highly arched eyebrow (HP:0002553)1.89307143
122Midline defect of the nose (HP:0004122)1.88969594
123Lethargy (HP:0001254)1.88853449
124Vaginal atresia (HP:0000148)1.88551181
125Holoprosencephaly (HP:0001360)1.88391005
126Excessive salivation (HP:0003781)1.87893339
127Tubular atrophy (HP:0000092)1.87172991
128Sclerocornea (HP:0000647)1.87162153
129Postaxial hand polydactyly (HP:0001162)1.87030327
130Bilateral microphthalmos (HP:0007633)1.86445058
131Hyperventilation (HP:0002883)1.85149867
132Anencephaly (HP:0002323)1.84294698
133Tubulointerstitial nephritis (HP:0001970)1.83686170
134Hypoplasia of the pons (HP:0012110)1.82871885
135Chorioretinal atrophy (HP:0000533)1.82858063
136Rhabdomyolysis (HP:0003201)1.82570422
137Breast aplasia (HP:0100783)1.82216285
138Hepatocellular carcinoma (HP:0001402)1.81436895
139Decreased central vision (HP:0007663)1.79676958
140Oculomotor apraxia (HP:0000657)1.79484573
141Dyschromatopsia (HP:0007641)1.78682113
142Absent radius (HP:0003974)1.78679155
143Aplasia involving forearm bones (HP:0009822)1.78628648
144Absent forearm bone (HP:0003953)1.78628648
145Abnormality of dicarboxylic acid metabolism (HP:0010995)1.77396191
146Dicarboxylic aciduria (HP:0003215)1.77396191
147Astigmatism (HP:0000483)1.76460470
148Triphalangeal thumb (HP:0001199)1.75996481
149Abnormality of the pons (HP:0007361)1.74669143
150Prominent nasal bridge (HP:0000426)1.74457529
151Absent speech (HP:0001344)1.73915676
152Truncal obesity (HP:0001956)1.73758055
153Gonadotropin excess (HP:0000837)1.73511378
154Neoplasm of the rectum (HP:0100743)1.73276664
155True hermaphroditism (HP:0010459)1.73256872
156Abnormality of glutamine family amino acid metabolism (HP:0010902)1.72924572
157Abnormality of DNA repair (HP:0003254)1.72356270
158Abnormal lung lobation (HP:0002101)1.72286881
159Erectile abnormalities (HP:0100639)1.70900304
160Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.70311518
161Renal hypoplasia (HP:0000089)1.70023940
162Abnormality of fatty-acid metabolism (HP:0004359)1.69985712
163Progressive inability to walk (HP:0002505)1.69185499
164Neoplasm of striated muscle (HP:0009728)1.69070962
165Cholelithiasis (HP:0001081)1.68992671
166Renal cortical cysts (HP:0000803)1.68700514
167Malnutrition (HP:0004395)1.68150772
168Abnormality of the preputium (HP:0100587)1.67955978
169Hip dysplasia (HP:0001385)1.67233731
170Acanthocytosis (HP:0001927)1.65970931
171Skin nodule (HP:0200036)1.65931716
172Cerebellar dysplasia (HP:0007033)1.65866901
173Gastrointestinal atresia (HP:0002589)1.65715796
174Pachygyria (HP:0001302)1.65397191
175Aganglionic megacolon (HP:0002251)1.65038433
176Abnormal spermatogenesis (HP:0008669)1.65000387
177Papillary thyroid carcinoma (HP:0002895)1.64890213
178Fair hair (HP:0002286)1.64647066
179Micropenis (HP:0000054)1.64099671
180Abnormal gallbladder morphology (HP:0012437)1.63951172
181Abnormality of the renal cortex (HP:0011035)1.63298506
182Ovarian neoplasm (HP:0100615)1.62089272

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.18105371
2STK38L3.91237499
3FRK3.27617350
4NEK13.11138426
5PDK43.07773770
6PDK33.07773770
7CLK12.85051419
8WNK32.61402792
9TTK2.48609635
10BMPR1B2.48096530
11BCKDK2.44522445
12NEK22.33133923
13TRIM282.31147235
14CASK2.29327107
15STK162.28293937
16MKNK22.26932236
17CDC72.24729344
18MAP4K22.22102058
19PNCK2.13833465
20EIF2AK12.09292322
21ZAK1.85436723
22RIPK11.83202766
23BUB11.82022987
24PLK31.78297135
25TAF11.76515992
26BCR1.75293433
27PRKD31.75160793
28EEF2K1.71909512
29CDK41.68362206
30LATS21.68251643
31CHEK21.62855730
32ERBB41.61046718
33MARK11.58402631
34DYRK31.55654966
35PLK11.53483338
36MAPK131.51413369
37MAP3K41.51316799
38CDK61.51240052
39NUAK11.49044559
40VRK11.47357927
41MKNK11.46825050
42PDK21.41840736
43STK381.38280167
44MAP2K31.37303770
45PLK21.34468982
46RPS6KB21.33093423
47CAMK1G1.31505973
48BRD41.28918181
49AKT31.24671613
50MAP3K31.23057580
51KSR11.20004577
52TNIK1.19953204
53WEE11.19177999
54CDK121.14747819
55NEK91.12501439
56ERBB31.11638849
57NTRK21.09894286
58EPHB21.08661350
59ATR1.08190824
60ICK1.07713739
61PKN21.07354100
62EIF2AK31.05664672
63LATS11.05631055
64STK31.04290025
65TAOK11.03638139
66BRSK21.02125596
67TLK10.99852876
68CSNK1G20.98147338
69SGK4940.97596222
70SGK2230.97596222
71FGFR40.97059848
72CDK90.96579778
73PRKAA10.95308232
74ADRBK20.95267392
75SGK20.94178300
76FGFR20.94020531
77CSNK1A1L0.91650383
78EPHA30.91614414
79CHEK10.91610081
80AURKA0.91461749
81PBK0.90928175
82SIK30.88643339
83AURKB0.88296275
84DYRK20.86084431
85MAP2K70.83687677
86CDK30.82108104
87TGFBR10.80613453
88SRPK10.78583883
89PAK60.76967750
90STK100.76087350
91PKN10.76023509
92MAPK110.75911025
93CDK20.74909380
94INSRR0.73917808
95CDK10.73467732
96STK390.73274681
97ATM0.72757358
98STK240.71903934
99PASK0.70846290
100CCNB10.70311474
101TAOK30.69191683
102NTRK30.69072365
103EPHA20.67949458
104WNK40.67719021
105SGK30.67332869
106FGFR10.66335377
107TYRO30.64748684
108MTOR0.63116658
109PHKG20.62195764
110PHKG10.62195764
111NTRK10.62163223
112GRK10.62145534
113SIK20.61789612
114MET0.60036879
115NEK60.60019300
116TSSK60.59821994
117MELK0.59330247
118OXSR10.58903035
119CDK70.58744578
120TTN0.57584626
121PAK30.55858742
122BRAF0.55469413
123PAK40.53538576
124SIK10.52985077
125CSNK1D0.52615796
126RPS6KA40.52466548
127MAP3K80.51828549
128TAOK20.51784060
129PRKCE0.51096316
130CAMK1D0.50778987
131ILK0.50502012
132DAPK20.46721335
133GSK3A0.45742774
134CDK80.45656044
135BRSK10.44385257
136ACVR1B0.42989719
137LMTK20.41212688
138CSNK1G10.40361280
139RAF10.40349590
140MAP3K110.39817841
141MST40.39631635
142PLK40.39026625
143PRKDC0.38914856
144MAPK100.38025877
145MAPK90.37570063
146OBSCN0.36357621
147CSNK1E0.36244463
148PINK10.35764178
149MUSK0.34969902
150ALK0.34712229
151PRKCI0.33627157
152CSNK1G30.33145307
153CDK150.32971458

Predicted pathways (KEGG)

RankGene SetZ-score
1Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.98071099
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.90890668
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.86910848
4Propanoate metabolism_Homo sapiens_hsa006402.54574067
5Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.49469876
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.43169868
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.41833053
8Pyruvate metabolism_Homo sapiens_hsa006202.41789099
9Nitrogen metabolism_Homo sapiens_hsa009102.36924022
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.32647076
11Arginine biosynthesis_Homo sapiens_hsa002202.25769218
12Fatty acid degradation_Homo sapiens_hsa000712.23332442
13Biosynthesis of amino acids_Homo sapiens_hsa012302.17676292
14Tryptophan metabolism_Homo sapiens_hsa003802.12285992
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.11281285
16One carbon pool by folate_Homo sapiens_hsa006702.10864830
17Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.07520987
18Butanoate metabolism_Homo sapiens_hsa006502.07037466
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.99327473
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.96586491
21Vitamin B6 metabolism_Homo sapiens_hsa007501.95220978
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.94331686
23Selenocompound metabolism_Homo sapiens_hsa004501.90971850
24Lysine degradation_Homo sapiens_hsa003101.84214998
25TGF-beta signaling pathway_Homo sapiens_hsa043501.74218643
26Carbon metabolism_Homo sapiens_hsa012001.73172382
27Fatty acid metabolism_Homo sapiens_hsa012121.67551895
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.66406965
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.62273980
30DNA replication_Homo sapiens_hsa030301.54090694
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.52519126
32PPAR signaling pathway_Homo sapiens_hsa033201.49872374
33Complement and coagulation cascades_Homo sapiens_hsa046101.46266523
34Mismatch repair_Homo sapiens_hsa034301.44268871
35Peroxisome_Homo sapiens_hsa041461.36584543
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34970370
37Cell cycle_Homo sapiens_hsa041101.33013209
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.31426726
39Retinol metabolism_Homo sapiens_hsa008301.29296128
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.29186513
41Base excision repair_Homo sapiens_hsa034101.27515147
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.27368526
43Protein export_Homo sapiens_hsa030601.25561123
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.24721860
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19406493
46Folate biosynthesis_Homo sapiens_hsa007901.15468032
47RNA transport_Homo sapiens_hsa030131.13694206
48Non-homologous end-joining_Homo sapiens_hsa034501.12820588
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03119792
50Nicotine addiction_Homo sapiens_hsa050331.01594049
51beta-Alanine metabolism_Homo sapiens_hsa004101.00688358
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.99484652
53Glucagon signaling pathway_Homo sapiens_hsa049220.96556734
54Wnt signaling pathway_Homo sapiens_hsa043100.94200036
55Arginine and proline metabolism_Homo sapiens_hsa003300.93019540
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92986519
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92871390
58Bile secretion_Homo sapiens_hsa049760.92574689
59Olfactory transduction_Homo sapiens_hsa047400.92176660
60Fatty acid elongation_Homo sapiens_hsa000620.92137071
61Spliceosome_Homo sapiens_hsa030400.91435394
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91105847
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90067542
64Nucleotide excision repair_Homo sapiens_hsa034200.89933898
65Chemical carcinogenesis_Homo sapiens_hsa052040.89304057
66RNA polymerase_Homo sapiens_hsa030200.89221513
67Regulation of autophagy_Homo sapiens_hsa041400.88844274
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87263423
69Axon guidance_Homo sapiens_hsa043600.87029878
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82677025
71Fat digestion and absorption_Homo sapiens_hsa049750.81741324
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.78804885
73Dorso-ventral axis formation_Homo sapiens_hsa043200.78047236
74MicroRNAs in cancer_Homo sapiens_hsa052060.76630997
75Melanoma_Homo sapiens_hsa052180.72359302
76RNA degradation_Homo sapiens_hsa030180.70965112
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70852960
78Starch and sucrose metabolism_Homo sapiens_hsa005000.69885019
79Tyrosine metabolism_Homo sapiens_hsa003500.69840813
80Alcoholism_Homo sapiens_hsa050340.69518010
81Sulfur relay system_Homo sapiens_hsa041220.68440841
82Phototransduction_Homo sapiens_hsa047440.67929032
83Phenylalanine metabolism_Homo sapiens_hsa003600.66807571
84Colorectal cancer_Homo sapiens_hsa052100.63963905
85Pentose phosphate pathway_Homo sapiens_hsa000300.62039862
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61713603
87Taste transduction_Homo sapiens_hsa047420.61677395
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60763477
89Glutamatergic synapse_Homo sapiens_hsa047240.59300392
90Proteasome_Homo sapiens_hsa030500.59134929
91Pyrimidine metabolism_Homo sapiens_hsa002400.59131439
92Fanconi anemia pathway_Homo sapiens_hsa034600.56591167
93Basal transcription factors_Homo sapiens_hsa030220.55540494
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55406557
95Homologous recombination_Homo sapiens_hsa034400.54173182
96mRNA surveillance pathway_Homo sapiens_hsa030150.52648579
97Histidine metabolism_Homo sapiens_hsa003400.51434196
98Long-term depression_Homo sapiens_hsa047300.51147608
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50955113
100Prostate cancer_Homo sapiens_hsa052150.49641615
101Hedgehog signaling pathway_Homo sapiens_hsa043400.49596126
102Sphingolipid metabolism_Homo sapiens_hsa006000.48994578
103Basal cell carcinoma_Homo sapiens_hsa052170.48710255
104Vitamin digestion and absorption_Homo sapiens_hsa049770.48645181
105Glutathione metabolism_Homo sapiens_hsa004800.48022010
106Caffeine metabolism_Homo sapiens_hsa002320.46065646
107Oocyte meiosis_Homo sapiens_hsa041140.45784585
108Purine metabolism_Homo sapiens_hsa002300.43587576
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43120747
110ABC transporters_Homo sapiens_hsa020100.42941566
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42718471
112Inositol phosphate metabolism_Homo sapiens_hsa005620.42492489
113Staphylococcus aureus infection_Homo sapiens_hsa051500.42290452
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.42074764
115Systemic lupus erythematosus_Homo sapiens_hsa053220.42042122
116p53 signaling pathway_Homo sapiens_hsa041150.42035497
117N-Glycan biosynthesis_Homo sapiens_hsa005100.41105533
118Metabolic pathways_Homo sapiens_hsa011000.40110699
119Fructose and mannose metabolism_Homo sapiens_hsa000510.39391500
120Steroid biosynthesis_Homo sapiens_hsa001000.39153808
121Glycerolipid metabolism_Homo sapiens_hsa005610.39002897
122FoxO signaling pathway_Homo sapiens_hsa040680.38596819
123Fatty acid biosynthesis_Homo sapiens_hsa000610.38207801
124Calcium signaling pathway_Homo sapiens_hsa040200.37785758
125Morphine addiction_Homo sapiens_hsa050320.37690274
126Circadian rhythm_Homo sapiens_hsa047100.35788237
127Cocaine addiction_Homo sapiens_hsa050300.35548279
128AMPK signaling pathway_Homo sapiens_hsa041520.34949800
129Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34772245
130Hippo signaling pathway_Homo sapiens_hsa043900.32294057
131Adherens junction_Homo sapiens_hsa045200.31870624
132Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30456423
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28166551
134Insulin resistance_Homo sapiens_hsa049310.27258492
135GABAergic synapse_Homo sapiens_hsa047270.25795604
136Glioma_Homo sapiens_hsa052140.25656663
137Viral carcinogenesis_Homo sapiens_hsa052030.24701473
138Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.24621692
139Endometrial cancer_Homo sapiens_hsa052130.24301170
140mTOR signaling pathway_Homo sapiens_hsa041500.23195497
141Circadian entrainment_Homo sapiens_hsa047130.22286691
142ErbB signaling pathway_Homo sapiens_hsa040120.19623945
143Bladder cancer_Homo sapiens_hsa052190.18661959

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