ZKSCAN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.46381833
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.99319090
3vocalization behavior (GO:0071625)4.82169252
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.71972448
5ionotropic glutamate receptor signaling pathway (GO:0035235)4.68900811
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.63390428
7neuron cell-cell adhesion (GO:0007158)4.55066832
8protein localization to synapse (GO:0035418)4.50119055
9regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.41694733
10glutamate receptor signaling pathway (GO:0007215)4.39461669
11neurotransmitter-gated ion channel clustering (GO:0072578)4.36970253
12regulation of glutamate receptor signaling pathway (GO:1900449)4.33951082
13pyrimidine nucleobase catabolic process (GO:0006208)4.32830855
14synaptic vesicle maturation (GO:0016188)4.32400722
15locomotory exploration behavior (GO:0035641)4.28928363
16synaptic transmission, glutamatergic (GO:0035249)4.27245110
17synaptic vesicle exocytosis (GO:0016079)4.24986823
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.24241019
19regulation of synaptic vesicle exocytosis (GO:2000300)4.23151889
20synaptic vesicle docking involved in exocytosis (GO:0016081)4.10995281
21G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.10330491
22neuron-neuron synaptic transmission (GO:0007270)4.04844639
23glutamate secretion (GO:0014047)3.96835894
24presynaptic membrane assembly (GO:0097105)3.96257037
25membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.82477965
26response to pheromone (GO:0019236)3.76340958
27regulation of synaptic vesicle transport (GO:1902803)3.74135029
28presynaptic membrane organization (GO:0097090)3.71449116
29neurotransmitter secretion (GO:0007269)3.70728919
30postsynaptic membrane organization (GO:0001941)3.68818392
31regulation of long-term neuronal synaptic plasticity (GO:0048169)3.61570861
32neuron recognition (GO:0008038)3.60707401
33startle response (GO:0001964)3.60588905
34regulation of neuronal synaptic plasticity (GO:0048168)3.57738884
35negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.53404578
36synaptic vesicle endocytosis (GO:0048488)3.49283388
37exploration behavior (GO:0035640)3.49213782
38regulation of synaptic transmission, glutamatergic (GO:0051966)3.49036293
39cellular potassium ion homeostasis (GO:0030007)3.48513090
40cerebellar Purkinje cell differentiation (GO:0021702)3.47864396
41long-term memory (GO:0007616)3.46224933
42dendritic spine morphogenesis (GO:0060997)3.45809921
43regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.45341603
44response to auditory stimulus (GO:0010996)3.45080965
45axonal fasciculation (GO:0007413)3.41285220
46regulation of excitatory postsynaptic membrane potential (GO:0060079)3.41283383
47regulation of postsynaptic membrane potential (GO:0060078)3.41101804
48neuronal action potential propagation (GO:0019227)3.40721758
49gamma-aminobutyric acid transport (GO:0015812)3.40700588
50transmission of nerve impulse (GO:0019226)3.39966877
51membrane hyperpolarization (GO:0060081)3.39556473
52negative regulation of synaptic transmission, GABAergic (GO:0032229)3.37883766
53layer formation in cerebral cortex (GO:0021819)3.36499659
54negative regulation of cytosolic calcium ion concentration (GO:0051481)3.33867674
55auditory behavior (GO:0031223)3.33144085
56mitotic sister chromatid cohesion (GO:0007064)3.32511725
57gamma-aminobutyric acid signaling pathway (GO:0007214)3.31089787
58regulation of DNA endoreduplication (GO:0032875)3.29646964
59pre-miRNA processing (GO:0031054)3.29272503
60positive regulation of synapse maturation (GO:0090129)3.28137857
61righting reflex (GO:0060013)3.27076708
62positive regulation of membrane potential (GO:0045838)3.26348694
63regulation of synapse structural plasticity (GO:0051823)3.26103113
64positive regulation of synaptic transmission, GABAergic (GO:0032230)3.24613943
65innervation (GO:0060384)3.21778758
66neurotransmitter transport (GO:0006836)3.21766602
67response to histamine (GO:0034776)3.19513791
68nucleobase catabolic process (GO:0046113)3.18589054
69regulation of neurotransmitter secretion (GO:0046928)3.17351855
70regulation of respiratory system process (GO:0044065)3.15838217
71dendrite morphogenesis (GO:0048813)3.15025945
72positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.13769435
73membrane depolarization during action potential (GO:0086010)3.12715494
74long-term synaptic potentiation (GO:0060291)3.10867153
75regulation of synapse maturation (GO:0090128)3.09007054
76synapse assembly (GO:0007416)3.08305341
77nuclear pore complex assembly (GO:0051292)3.07261161
78central nervous system projection neuron axonogenesis (GO:0021952)3.06721184
79limb bud formation (GO:0060174)3.06064203
80protein localization to chromosome (GO:0034502)3.05801295
81proline transport (GO:0015824)3.05331756
82protein localization to chromosome, centromeric region (GO:0071459)3.05257775
83nuclear pore organization (GO:0006999)3.03644932
84positive regulation of dendritic spine morphogenesis (GO:0061003)3.02597997
85cell migration in hindbrain (GO:0021535)3.00859307
86L-amino acid import (GO:0043092)2.99541013
87establishment of mitochondrion localization (GO:0051654)2.98883118
88behavioral fear response (GO:0001662)2.97189033
89behavioral defense response (GO:0002209)2.97189033
90mitotic chromosome condensation (GO:0007076)2.96863742
91mechanosensory behavior (GO:0007638)2.96363284
92membrane depolarization (GO:0051899)2.95334108
93regulation of neurotransmitter transport (GO:0051588)2.93521602
94positive regulation of synapse assembly (GO:0051965)2.92304412
95adult walking behavior (GO:0007628)2.92276540
96learning (GO:0007612)2.91446173
97olfactory bulb development (GO:0021772)2.90997533
98regulation of synaptic plasticity (GO:0048167)2.90798010
99protein localization to kinetochore (GO:0034501)2.90780921
100positive regulation of neurotransmitter secretion (GO:0001956)2.89768436
101cerebellar granule cell differentiation (GO:0021707)2.88534987
102neuronal ion channel clustering (GO:0045161)2.87964367
103cell communication by electrical coupling (GO:0010644)2.87107689
104prepulse inhibition (GO:0060134)2.86291165
105positive regulation of neurotransmitter transport (GO:0051590)2.85819389
106regulation of synaptic transmission, GABAergic (GO:0032228)2.85421683
107regulation of respiratory gaseous exchange (GO:0043576)2.84753378
108heterochromatin organization (GO:0070828)2.82735953
109regulation of vesicle fusion (GO:0031338)2.79808393
110cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.78086130
111regulation of neurotransmitter levels (GO:0001505)2.77948207
112cytoplasmic mRNA processing body assembly (GO:0033962)2.76295037
113striatum development (GO:0021756)2.76250634
114regulation of dendritic spine morphogenesis (GO:0061001)2.76026730
115regulation of synapse assembly (GO:0051963)2.75080608
116chromatin remodeling at centromere (GO:0031055)2.75033867
117paraxial mesoderm development (GO:0048339)2.74149551
118synaptic transmission (GO:0007268)2.73921583
119kinetochore organization (GO:0051383)2.71115300
120sister chromatid segregation (GO:0000819)2.70989028
121DNA double-strand break processing (GO:0000729)2.69921167
122mitotic metaphase plate congression (GO:0007080)2.67337231
123negative regulation of translation, ncRNA-mediated (GO:0040033)2.66161969
124regulation of translation, ncRNA-mediated (GO:0045974)2.66161969
125negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.66161969
126forebrain neuron differentiation (GO:0021879)2.60131966
127nonmotile primary cilium assembly (GO:0035058)2.58779112
128regulation of centriole replication (GO:0046599)2.58470122
129microtubule depolymerization (GO:0007019)2.58417653
130establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.55530594
131mitochondrion transport along microtubule (GO:0047497)2.55530594
132neuronal stem cell maintenance (GO:0097150)2.54725799
133ATP-dependent chromatin remodeling (GO:0043044)2.53549414
134retinal ganglion cell axon guidance (GO:0031290)2.53407470
135resolution of meiotic recombination intermediates (GO:0000712)2.52075037
136CENP-A containing nucleosome assembly (GO:0034080)2.48417234
137behavioral response to nicotine (GO:0035095)2.47632190
138centriole replication (GO:0007099)2.47039475
139histone H2A acetylation (GO:0043968)2.46177272
140mitotic sister chromatid segregation (GO:0000070)2.45527153
141metaphase plate congression (GO:0051310)2.44754643
142negative regulation of DNA-dependent DNA replication (GO:2000104)2.44682593
143spermatid nucleus differentiation (GO:0007289)2.44584048
144limb development (GO:0060173)2.44243591
145appendage development (GO:0048736)2.44243591
146maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.44183770
147replication fork processing (GO:0031297)2.42939797
148histone exchange (GO:0043486)2.42717046
149protein-DNA complex disassembly (GO:0032986)2.41539848
150nucleosome disassembly (GO:0006337)2.41539848
151body morphogenesis (GO:0010171)2.41247050
152kinetochore assembly (GO:0051382)2.41119994
153DNA replication-dependent nucleosome assembly (GO:0006335)2.39237741
154DNA replication-dependent nucleosome organization (GO:0034723)2.39237741
155positive regulation of gastrulation (GO:2000543)2.35791390
156sister chromatid cohesion (GO:0007062)2.34905427
157chromatin assembly (GO:0031497)2.34406926
158somite development (GO:0061053)2.33104161
159microtubule anchoring (GO:0034453)2.30347665
160negative regulation of DNA recombination (GO:0045910)2.30110978
161DNA replication checkpoint (GO:0000076)2.29763291
162embryonic retina morphogenesis in camera-type eye (GO:0060059)2.29244071
163DNA replication-independent nucleosome assembly (GO:0006336)2.28971113
164DNA replication-independent nucleosome organization (GO:0034724)2.28971113
165cell proliferation in forebrain (GO:0021846)2.28831619
166regulation of NFAT protein import into nucleus (GO:0051532)2.27907029
167DNA topological change (GO:0006265)2.27647699
168centrosome duplication (GO:0051298)2.26645460
169negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.26063692
170regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.24212107
171embryonic body morphogenesis (GO:0010172)2.23020851
172regulation of centrosome cycle (GO:0046605)2.22041322
173spinal cord development (GO:0021510)2.21843933
174ganglion development (GO:0061548)2.21814421
175microtubule polymerization or depolymerization (GO:0031109)2.19986949
176cerebral cortex radially oriented cell migration (GO:0021799)2.19539750
177somite rostral/caudal axis specification (GO:0032525)2.19196840
178regulation of RNA export from nucleus (GO:0046831)2.18409149
179acrosome assembly (GO:0001675)2.17932389
180hippocampus development (GO:0021766)2.15892356
181spindle checkpoint (GO:0031577)2.15527793
182NLS-bearing protein import into nucleus (GO:0006607)2.14436249
183negative regulation of histone methylation (GO:0031061)2.14241130
184head development (GO:0060322)2.12696932
185regulation of centrosome duplication (GO:0010824)2.12496882
186neural tube formation (GO:0001841)2.12380288
187regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.11584691

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.93646413
2E2F7_22180533_ChIP-Seq_HELA_Human4.41590021
3GBX2_23144817_ChIP-Seq_PC3_Human4.37319893
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.80144136
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.47462341
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.18882054
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.05304486
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.77226829
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.76936911
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.75215739
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.66604922
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.64606811
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.47348381
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39102746
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.38592694
16KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.35068564
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.33746435
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.33647562
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.33647562
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.32602421
21* REST_21632747_ChIP-Seq_MESCs_Mouse2.32312490
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.28402283
23DROSHA_22980978_ChIP-Seq_HELA_Human2.25756645
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.25072117
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.10803313
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.10773920
27* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.10700874
28MTF2_20144788_ChIP-Seq_MESCs_Mouse2.09890403
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.06942399
30EZH2_27294783_Chip-Seq_ESCs_Mouse2.06727254
31* RNF2_27304074_Chip-Seq_ESCs_Mouse2.04554662
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.04417716
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.98437452
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97699592
35AR_21572438_ChIP-Seq_LNCaP_Human1.97200682
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96163516
37* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94155063
38POU5F1_16153702_ChIP-ChIP_HESCs_Human1.92444415
39SMAD4_21799915_ChIP-Seq_A2780_Human1.82305150
40EWS_26573619_Chip-Seq_HEK293_Human1.80688223
41TAF15_26573619_Chip-Seq_HEK293_Human1.80035361
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79095155
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.77764641
44HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.74679809
45* CBX2_27304074_Chip-Seq_ESCs_Mouse1.74498493
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73178355
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.72079704
48P300_19829295_ChIP-Seq_ESCs_Human1.71052569
49REST_18959480_ChIP-ChIP_MESCs_Mouse1.67614979
50RARB_27405468_Chip-Seq_BRAIN_Mouse1.67332393
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.62793393
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61264420
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.60714320
54IGF1R_20145208_ChIP-Seq_DFB_Human1.59764486
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54972039
56AR_21909140_ChIP-Seq_LNCAP_Human1.48535501
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.48056161
58RNF2_27304074_Chip-Seq_NSC_Mouse1.47531215
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46179824
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.45151081
61STAT3_23295773_ChIP-Seq_U87_Human1.43629070
62FUS_26573619_Chip-Seq_HEK293_Human1.43121916
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.42955028
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.40726534
65SOX2_16153702_ChIP-ChIP_HESCs_Human1.39603586
66E2F1_21310950_ChIP-Seq_MCF-7_Human1.39455407
67TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.37582811
68WT1_19549856_ChIP-ChIP_CCG9911_Human1.37368831
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35170093
70GATA1_26923725_Chip-Seq_HPCs_Mouse1.34729168
71BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32425129
72TCF4_23295773_ChIP-Seq_U87_Human1.31729817
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31553411
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.31490714
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31310716
76AR_25329375_ChIP-Seq_VCAP_Human1.31009108
77SOX9_26525672_Chip-Seq_HEART_Mouse1.29862753
78EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29259126
79* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28808757
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26235060
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25950479
82IRF1_19129219_ChIP-ChIP_H3396_Human1.25805704
83* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.25785311
84SOX2_21211035_ChIP-Seq_LN229_Gbm1.24374703
85* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23245302
86YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23091635
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22096393
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22096393
89VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21652222
90E2F1_18555785_Chip-Seq_ESCs_Mouse1.21609660
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21586546
92AR_19668381_ChIP-Seq_PC3_Human1.21414039
93MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.20370770
94* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.20089910
95ARNT_22903824_ChIP-Seq_MCF-7_Human1.19388240
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19286232
97PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15942479
98RING1B_27294783_Chip-Seq_ESCs_Mouse1.15915374
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15730561
100KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.15667606
101ER_23166858_ChIP-Seq_MCF-7_Human1.15492292
102MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.15315908
103HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15226499
104PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15000136
105RUNX2_22187159_ChIP-Seq_PCA_Human1.14874333
106NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14354714
107ZNF274_21170338_ChIP-Seq_K562_Hela1.13510780
108VDR_22108803_ChIP-Seq_LS180_Human1.13066863
109* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13036804
110TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13015827
111NOTCH1_21737748_ChIP-Seq_TLL_Human1.12907049
112NANOG_16153702_ChIP-ChIP_HESCs_Human1.12322244
113CMYC_18555785_Chip-Seq_ESCs_Mouse1.12071279
114MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12042497
115P53_22387025_ChIP-Seq_ESCs_Mouse1.12002125
116ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11388730
117SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11281007
118AHR_22903824_ChIP-Seq_MCF-7_Human1.10975899
119TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10768517
120MYC_18940864_ChIP-ChIP_HL60_Human1.10719245
121POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.09793522
122SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.09709035
123* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.08904755
124FLI1_27457419_Chip-Seq_LIVER_Mouse1.07714095
125UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07133711
126SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07041128
127EST1_17652178_ChIP-ChIP_JURKAT_Human1.06587795
128RING1B_27294783_Chip-Seq_NPCs_Mouse1.05451025
129SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05179704
130NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04761980
131PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04481360
132PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04203753
133CREB1_15753290_ChIP-ChIP_HEK293T_Human1.04129500
134MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02612902
135ISL1_27105846_Chip-Seq_CPCs_Mouse1.02483528
136SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.01558569
137RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00859443
138* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99972159
139PRDM14_20953172_ChIP-Seq_ESCs_Human0.98450314
140WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98372405
141EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.97812966
142* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.96609521
143* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.94498039
144* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93846722
145* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93219274
146* CBP_20019798_ChIP-Seq_JUKART_Human0.93219274
147ELK1_19687146_ChIP-ChIP_HELA_Human0.92904482
148TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.91845142
149TTF2_22483619_ChIP-Seq_HELA_Human0.90855046

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.90964264
2MP0003880_abnormal_central_pattern4.20902447
3MP0003635_abnormal_synaptic_transmissio3.51578635
4MP0004270_analgesia3.02496499
5MP0009745_abnormal_behavioral_response3.00771593
6MP0009046_muscle_twitch2.98893454
7MP0005423_abnormal_somatic_nervous2.95901174
8MP0002063_abnormal_learning/memory/cond2.91311413
9MP0001486_abnormal_startle_reflex2.81230165
10MP0002064_seizures2.71824663
11MP0001968_abnormal_touch/_nociception2.71359630
12MP0002572_abnormal_emotion/affect_behav2.60811087
13MP0001188_hyperpigmentation2.49045754
14MP0005551_abnormal_eye_electrophysiolog2.46088148
15MP0002734_abnormal_mechanical_nocicepti2.35754143
16MP0003787_abnormal_imprinting2.35101521
17MP0002272_abnormal_nervous_system2.33159292
18MP0008789_abnormal_olfactory_epithelium2.28802542
19MP0005646_abnormal_pituitary_gland2.21110248
20MP0002735_abnormal_chemical_nociception2.12559883
21MP0002736_abnormal_nociception_after2.09705447
22MP0002067_abnormal_sensory_capabilities2.04900219
23MP0000778_abnormal_nervous_system2.04155542
24MP0001293_anophthalmia2.04153809
25MP0010094_abnormal_chromosome_stability2.02437402
26MP0005645_abnormal_hypothalamus_physiol1.97272588
27MP0001501_abnormal_sleep_pattern1.96221114
28MP0002822_catalepsy1.95702049
29MP0006292_abnormal_olfactory_placode1.91206522
30MP0001502_abnormal_circadian_rhythm1.84648137
31MP0001440_abnormal_grooming_behavior1.84396618
32MP0003937_abnormal_limbs/digits/tail_de1.83569300
33MP0002557_abnormal_social/conspecific_i1.82858988
34MP0002184_abnormal_innervation1.80921986
35MP0003111_abnormal_nucleus_morphology1.80167828
36MP0006276_abnormal_autonomic_nervous1.78494628
37MP0003693_abnormal_embryo_hatching1.78250659
38MP0010030_abnormal_orbit_morphology1.77524217
39MP0008058_abnormal_DNA_repair1.77423819
40MP0001984_abnormal_olfaction1.76714682
41MP0008057_abnormal_DNA_replication1.73896753
42MP0003123_paternal_imprinting1.72318300
43MP0000049_abnormal_middle_ear1.70186005
44MP0002733_abnormal_thermal_nociception1.68930353
45MP0000569_abnormal_digit_pigmentation1.68396608
46MP0005386_behavior/neurological_phenoty1.64622182
47MP0004924_abnormal_behavior1.64622182
48MP0001970_abnormal_pain_threshold1.64126091
49MP0003122_maternal_imprinting1.61332960
50MP0002233_abnormal_nose_morphology1.59561660
51MP0008569_lethality_at_weaning1.56251433
52MP0003119_abnormal_digestive_system1.54970417
53MP0002882_abnormal_neuron_morphology1.53195169
54MP0006072_abnormal_retinal_apoptosis1.53186108
55MP0004133_heterotaxia1.51467552
56MP0005253_abnormal_eye_physiology1.50115378
57MP0002638_abnormal_pupillary_reflex1.48123013
58MP0004885_abnormal_endolymph1.47936368
59MP0003385_abnormal_body_wall1.45136309
60MP0000955_abnormal_spinal_cord1.43945816
61MP0004811_abnormal_neuron_physiology1.43573036
62MP0003077_abnormal_cell_cycle1.42997833
63MP0009780_abnormal_chondrocyte_physiolo1.42581729
64MP0002697_abnormal_eye_size1.42292788
65MP0002938_white_spotting1.42097050
66MP0001286_abnormal_eye_development1.36146774
67MP0010386_abnormal_urinary_bladder1.35088915
68MP0004142_abnormal_muscle_tone1.34280541
69MP0001529_abnormal_vocalization1.34261435
70MP0004742_abnormal_vestibular_system1.34153395
71MP0000631_abnormal_neuroendocrine_gland1.33293703
72MP0003879_abnormal_hair_cell1.32301791
73MP0002084_abnormal_developmental_patter1.32054123
74MP0003755_abnormal_palate_morphology1.28585389
75MP0003567_abnormal_fetal_cardiomyocyte1.27779968
76MP0003942_abnormal_urinary_system1.24669540
77MP0002066_abnormal_motor_capabilities/c1.24354651
78MP0002092_abnormal_eye_morphology1.23033132
79MP0000537_abnormal_urethra_morphology1.22100700
80MP0008932_abnormal_embryonic_tissue1.22096305
81MP0005409_darkened_coat_color1.21932638
82MP0005187_abnormal_penis_morphology1.20395789
83MP0005171_absent_coat_pigmentation1.18943065
84MP0004858_abnormal_nervous_system1.17378833
85MP0002752_abnormal_somatic_nervous1.15246236
86MP0003935_abnormal_craniofacial_develop1.14846490
87MP0002229_neurodegeneration1.14835113
88MP0002152_abnormal_brain_morphology1.12797671
89MP0004197_abnormal_fetal_growth/weight/1.10856783
90MP0000428_abnormal_craniofacial_morphol1.10212811
91MP0002085_abnormal_embryonic_tissue1.10188932
92MP0002102_abnormal_ear_morphology1.08669298
93MP0002909_abnormal_adrenal_gland1.07796993
94MP0001963_abnormal_hearing_physiology1.07727595
95MP0003315_abnormal_perineum_morphology1.07060529
96MP0002090_abnormal_vision1.06830433
97MP0009672_abnormal_birth_weight1.05642230
98MP0003938_abnormal_ear_development1.05142237
99MP0002081_perinatal_lethality1.03163354
100MP0003121_genomic_imprinting1.02577165
101MP0001905_abnormal_dopamine_level1.02185994
102MP0005499_abnormal_olfactory_system1.00162558
103MP0005394_taste/olfaction_phenotype1.00162558
104MP0002210_abnormal_sex_determination1.00135450
105MP0003633_abnormal_nervous_system0.99669539
106MP0005380_embryogenesis_phenotype0.98492921
107MP0001672_abnormal_embryogenesis/_devel0.98492921
108MP0005391_vision/eye_phenotype0.97671885
109MP0004957_abnormal_blastocyst_morpholog0.96921858
110MP0009053_abnormal_anal_canal0.94808823
111MP0002116_abnormal_craniofacial_bone0.94150144
112MP0000026_abnormal_inner_ear0.93916855
113MP0009703_decreased_birth_body0.93230795
114MP0001177_atelectasis0.92928235
115MP0001986_abnormal_taste_sensitivity0.92348265
116MP0000534_abnormal_ureter_morphology0.91517804
117MP0001929_abnormal_gametogenesis0.91288468
118MP0002160_abnormal_reproductive_system0.91165948
119MP0003631_nervous_system_phenotype0.90857130
120MP0003718_maternal_effect0.89743475
121MP0005195_abnormal_posterior_eye0.88835024
122MP0001730_embryonic_growth_arrest0.88069600
123MP0002249_abnormal_larynx_morphology0.87704582
124MP0002111_abnormal_tail_morphology0.86618589
125MP0000566_synostosis0.86270167
126MP0001697_abnormal_embryo_size0.86178230
127MP0003984_embryonic_growth_retardation0.84069004
128MP0002088_abnormal_embryonic_growth/wei0.83398260
129MP0002069_abnormal_eating/drinking_beha0.83333649
130MP0003136_yellow_coat_color0.83306314
131MP0009250_abnormal_appendicular_skeleto0.82432651
132MP0004145_abnormal_muscle_electrophysio0.82428598
133MP0003115_abnormal_respiratory_system0.82412430
134MP0001485_abnormal_pinna_reflex0.82090779
135MP0003698_abnormal_male_reproductive0.81076021
136MP0000653_abnormal_sex_gland0.79439359
137MP0001145_abnormal_male_reproductive0.78370034
138MP0001346_abnormal_lacrimal_gland0.78365054
139MP0008877_abnormal_DNA_methylation0.78038937
140MP0003634_abnormal_glial_cell0.78001421
141MP0004085_abnormal_heartbeat0.74621160
142MP0003632_abnormal_nervous_system0.74584117
143MP0002876_abnormal_thyroid_physiology0.74056941
144MP0001299_abnormal_eye_distance/0.73028529
145MP0002653_abnormal_ependyma_morphology0.72777222
146MP0003861_abnormal_nervous_system0.71954409
147MP0005248_abnormal_Harderian_gland0.70321061
148MP0003329_amyloid_beta_deposits0.69351859
149MP0003890_abnormal_embryonic-extraembry0.69185955
150MP0003137_abnormal_impulse_conducting0.69135785
151MP0003690_abnormal_glial_cell0.66049244
152MP0004215_abnormal_myocardial_fiber0.64057324
153MP0002234_abnormal_pharynx_morphology0.63480439
154MP0002751_abnormal_autonomic_nervous0.62755755
155MP0000015_abnormal_ear_pigmentation0.61206293
156MP0003183_abnormal_peptide_metabolism0.58180125
157MP0001943_abnormal_respiration0.57812174
158MP0002082_postnatal_lethality0.57482390
159MP0010770_preweaning_lethality0.57482390

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.54105769
2Febrile seizures (HP:0002373)5.42183117
3Epileptic encephalopathy (HP:0200134)4.88610685
4Congenital stationary night blindness (HP:0007642)4.70026478
5Focal seizures (HP:0007359)4.56618584
6Myokymia (HP:0002411)4.28749900
7Hepatoblastoma (HP:0002884)3.86348662
8Progressive cerebellar ataxia (HP:0002073)3.77067013
9Atonic seizures (HP:0010819)3.59911617
10Cortical dysplasia (HP:0002539)3.44638286
11Abnormality of the labia minora (HP:0012880)3.44337146
12Absence seizures (HP:0002121)3.38707052
13Generalized tonic-clonic seizures (HP:0002069)3.34050791
14Broad-based gait (HP:0002136)3.29472040
15Visual hallucinations (HP:0002367)3.28956036
16Volvulus (HP:0002580)3.20555706
17Chromosomal breakage induced by crosslinking agents (HP:0003221)3.17331257
18Chromsome breakage (HP:0040012)3.15411964
19Dialeptic seizures (HP:0011146)3.12313977
20Central scotoma (HP:0000603)2.95909289
21Hyperventilation (HP:0002883)2.86297820
22Gaze-evoked nystagmus (HP:0000640)2.84524019
23Action tremor (HP:0002345)2.77332651
24Drooling (HP:0002307)2.75738377
25Excessive salivation (HP:0003781)2.75738377
26Decreased central vision (HP:0007663)2.72239076
27Abnormality of macular pigmentation (HP:0008002)2.69893295
28High anterior hairline (HP:0009890)2.68921922
29Hemiparesis (HP:0001269)2.68753743
30Supranuclear gaze palsy (HP:0000605)2.67571039
31Aplasia/Hypoplasia of the sternum (HP:0006714)2.53560935
32Dysdiadochokinesis (HP:0002075)2.52565851
33Absent speech (HP:0001344)2.52225115
34Bony spicule pigmentary retinopathy (HP:0007737)2.49851176
35Ankle clonus (HP:0011448)2.49845381
36Poor eye contact (HP:0000817)2.43730354
37Papillary thyroid carcinoma (HP:0002895)2.43146395
38Protruding tongue (HP:0010808)2.42756071
39Gait imbalance (HP:0002141)2.42461783
40Abnormal rod and cone electroretinograms (HP:0008323)2.39049427
41Urinary bladder sphincter dysfunction (HP:0002839)2.36780385
42Genetic anticipation (HP:0003743)2.35742646
43Truncal ataxia (HP:0002078)2.33909455
44Depression (HP:0000716)2.33432637
45Severe visual impairment (HP:0001141)2.31838156
46Facial hemangioma (HP:0000329)2.30812101
47Oligodactyly (hands) (HP:0001180)2.30474547
48Septo-optic dysplasia (HP:0100842)2.29293631
49Dyschromatopsia (HP:0007641)2.29259835
50Abnormality of the septum pellucidum (HP:0007375)2.26263259
51Absent septum pellucidum (HP:0001331)2.25055134
52Epileptiform EEG discharges (HP:0011182)2.24278984
53Fetal akinesia sequence (HP:0001989)2.23121777
54Impaired vibration sensation in the lower limbs (HP:0002166)2.21219441
55Blue irides (HP:0000635)2.20527229
56Hypoplastic pelvis (HP:0008839)2.19803055
57Scotoma (HP:0000575)2.17709407
58Ectopic kidney (HP:0000086)2.15227959
59EEG with generalized epileptiform discharges (HP:0011198)2.13950817
60Oligodactyly (HP:0012165)2.13328195
61Aplasia/Hypoplasia of the uvula (HP:0010293)2.08943183
62Medial flaring of the eyebrow (HP:0010747)2.08894064
63Meckel diverticulum (HP:0002245)2.08790439
64Abnormal hair whorl (HP:0010721)2.08748503
65Medulloblastoma (HP:0002885)2.07029380
66Postural instability (HP:0002172)2.06840022
67Congenital primary aphakia (HP:0007707)2.05704644
68Abnormal eating behavior (HP:0100738)2.04072986
69Impaired social interactions (HP:0000735)2.03885224
70Abnormal social behavior (HP:0012433)2.03885224
71Mutism (HP:0002300)2.03576459
72Absent rod-and cone-mediated responses on ERG (HP:0007688)2.03561682
73Polyphagia (HP:0002591)2.03425457
74Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.03159155
75Abnormality of the ileum (HP:0001549)2.02982096
76Nephrogenic diabetes insipidus (HP:0009806)2.00949643
77Amblyopia (HP:0000646)1.99917950
78Dysmetria (HP:0001310)1.99601394
79Nephroblastoma (Wilms tumor) (HP:0002667)1.98295601
80Abnormality of salivation (HP:0100755)1.96814741
81Abnormality of binocular vision (HP:0011514)1.95631257
82Diplopia (HP:0000651)1.95631257
83Abnormality of chromosome stability (HP:0003220)1.95230460
84Stereotypic behavior (HP:0000733)1.92968929
85Intestinal atresia (HP:0011100)1.91193517
86Patellar aplasia (HP:0006443)1.90714571
87Specific learning disability (HP:0001328)1.90697247
88Diastasis recti (HP:0001540)1.90566667
89Anxiety (HP:0000739)1.89724547
90Spastic gait (HP:0002064)1.89291823
91Progressive inability to walk (HP:0002505)1.88957000
92Agitation (HP:0000713)1.88904476
93Abnormal EKG (HP:0003115)1.88425693
94Optic nerve hypoplasia (HP:0000609)1.88344028
95Impaired smooth pursuit (HP:0007772)1.88131386
96Hypsarrhythmia (HP:0002521)1.87795715
97Pendular nystagmus (HP:0012043)1.87304457
98Embryonal renal neoplasm (HP:0011794)1.86550078
99Prolonged QT interval (HP:0001657)1.85598337
100Abnormality of the metopic suture (HP:0005556)1.84868138
101Inability to walk (HP:0002540)1.84673991
102Micropenis (HP:0000054)1.84620886
103Poor coordination (HP:0002370)1.84407736
104Increased nuchal translucency (HP:0010880)1.82172654
105Dynein arm defect of respiratory motile cilia (HP:0012255)1.81796934
106Absent/shortened dynein arms (HP:0200106)1.81796934
107Hemiplegia (HP:0002301)1.81473869
108Labial hypoplasia (HP:0000066)1.81276891
109Absent radius (HP:0003974)1.80614581
110Limb dystonia (HP:0002451)1.80381109
111Lissencephaly (HP:0001339)1.80123044
112Abnormality of ocular smooth pursuit (HP:0000617)1.80094420
113Scanning speech (HP:0002168)1.80004134
114Lower limb muscle weakness (HP:0007340)1.79756496
115Hypoplastic female external genitalia (HP:0012815)1.78658973
116Abnormal lung lobation (HP:0002101)1.78337839
117Partial agenesis of the corpus callosum (HP:0001338)1.78066573
118Inappropriate behavior (HP:0000719)1.77596671
119Cutaneous syndactyly (HP:0012725)1.76273135
120Supernumerary spleens (HP:0009799)1.75066062
121Aqueductal stenosis (HP:0002410)1.74201765
122Aplasia involving forearm bones (HP:0009822)1.74033306
123Absent forearm bone (HP:0003953)1.74033306
124Choroideremia (HP:0001139)1.73009371
125Genital tract atresia (HP:0001827)1.72689762
126Widely spaced teeth (HP:0000687)1.72224037
127Colon cancer (HP:0003003)1.71953263
128Midline defect of the nose (HP:0004122)1.71732335
129Exotropia (HP:0000577)1.71226761
130Chronic hepatic failure (HP:0100626)1.71077803
131Anophthalmia (HP:0000528)1.70709581
132Short 4th metacarpal (HP:0010044)1.70586466
133Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.70586466
134Obsessive-compulsive behavior (HP:0000722)1.70331771
135Vaginal atresia (HP:0000148)1.70263896
136Megalencephaly (HP:0001355)1.70016192
137Increased corneal curvature (HP:0100692)1.69779056
138Keratoconus (HP:0000563)1.69779056
139True hermaphroditism (HP:0010459)1.69637543
140Myelomeningocele (HP:0002475)1.69606649
141Autism (HP:0000717)1.68208521
142Torticollis (HP:0000473)1.67903598
143Status epilepticus (HP:0002133)1.67826764
144Abnormal pancreas size (HP:0012094)1.67466773
145Aplasia/Hypoplasia of the patella (HP:0006498)1.66993045
146Broad alveolar ridges (HP:0000187)1.66661140
147Bradykinesia (HP:0002067)1.66650172
148Birth length less than 3rd percentile (HP:0003561)1.66647148
149Abnormality of the corticospinal tract (HP:0002492)1.66206956
150Cutaneous finger syndactyly (HP:0010554)1.65245139
151Tented upper lip vermilion (HP:0010804)1.64875112
152Esotropia (HP:0000565)1.64466680
153Aplasia of the phalanges of the hand (HP:0009802)1.64355870
154Horseshoe kidney (HP:0000085)1.62629001
155Triphalangeal thumb (HP:0001199)1.61685693
156Trigonocephaly (HP:0000243)1.61614383
157Pachygyria (HP:0001302)1.61584643
158Urinary urgency (HP:0000012)1.59637057
159Embryonal neoplasm (HP:0002898)1.58902685
160Vertebral arch anomaly (HP:0008438)1.58676053
161Abnormality of the antihelix (HP:0009738)1.56948989
162Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.56871103
163Hemivertebrae (HP:0002937)1.56760601
164Renal hypoplasia (HP:0000089)1.54754497
165Esophageal atresia (HP:0002032)1.54343892
166Maternal diabetes (HP:0009800)1.54219681
167Preaxial hand polydactyly (HP:0001177)1.53720180
168Abnormality of the aortic arch (HP:0012303)1.51845833
169Abnormality of the carotid arteries (HP:0005344)1.51382955
170Truncal obesity (HP:0001956)1.51082313
171Shawl scrotum (HP:0000049)1.50498770
172Decreased lacrimation (HP:0000633)1.50490519
173Bifid tongue (HP:0010297)1.50240056
174Abnormality of the intervertebral disk (HP:0005108)1.50190714
175Abnormality of the 4th metacarpal (HP:0010012)1.49611144
176Thyroid carcinoma (HP:0002890)1.49461454
177Hypoplastic labia majora (HP:0000059)1.49152767
178Neoplasm of the oral cavity (HP:0100649)1.48276486
179Hypoplasia of the capital femoral epiphysis (HP:0003090)1.47865631
180Rib fusion (HP:0000902)1.47839474
181Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.47366019
182Absent epiphyses (HP:0010577)1.47366019
183Bicornuate uterus (HP:0000813)1.46643570
184Abnormal number of incisors (HP:0011064)1.46609154

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.14737587
2CASK3.68115722
3MARK13.66271742
4EPHA43.36337134
5TNIK3.04361017
6PRPF4B2.95561368
7MAP2K72.84992703
8MAP3K42.80894018
9CDC72.65069534
10NTRK22.59417995
11MAP3K92.42878444
12MAPK132.11959356
13PLK42.05169529
14WEE12.02915834
15MINK12.00035184
16TTK1.90451129
17NEK11.82183148
18DYRK21.73933722
19TRIM281.69473496
20PAK61.68113681
21SRPK11.67412175
22SIK31.60599435
23DAPK21.58584708
24CDK121.55888820
25SIK21.52749272
26KSR11.51185483
27SGK21.46832139
28PRKD31.46053184
29INSRR1.44882032
30DYRK31.42897356
31MAP3K101.38988389
32MKNK11.37243709
33SGK2231.33596371
34SGK4941.33596371
35RIPK41.32791583
36MAP2K41.31363051
37TAF11.31071984
38PLK21.28745152
39MAP3K121.28341402
40ERBB31.28320994
41CDK51.27635061
42BRSK21.21468432
43PRKCG1.21006907
44LATS11.16466947
45AKT31.15406355
46FES1.07981030
47PLK11.07925121
48PLK31.07901247
49DYRK1A1.07329320
50CAMKK11.05438528
51PHKG21.04207443
52PHKG11.04207443
53WNK31.02480109
54STK381.01922736
55CAMK1G1.00054255
56CAMK2A0.98769689
57SGK30.98618818
58EPHB20.98263489
59PNCK0.97870754
60EEF2K0.97521380
61TSSK60.97516450
62NEK20.96343853
63CHEK20.95772265
64SGK10.92890988
65OBSCN0.92596128
66ZAK0.92434897
67UHMK10.90249019
68DAPK10.89520189
69ATM0.89409217
70CHEK10.88627161
71CAMK10.86333031
72ATR0.85157007
73BCR0.83670884
74CDK190.83025304
75NEK60.81157467
76YES10.80643647
77PRKCE0.80362475
78RPS6KA40.80306297
79BMPR20.79831500
80GRK10.78995098
81FGFR20.78877846
82CDK30.77985688
83ERBB40.76479594
84BRSK10.75770927
85GRK50.75764434
86MUSK0.75305862
87NTRK10.75213062
88MARK30.74679929
89STK38L0.74595269
90PKN10.74419182
91PINK10.72695177
92VRK10.71765382
93AURKB0.70469992
94MKNK20.69269612
95TNK20.68928174
96CAMKK20.68861789
97MAP4K20.68133330
98ADRBK20.67144426
99MARK20.66186318
100CDK10.65662450
101CDK180.65583687
102PASK0.65557899
103CAMK2B0.65240144
104CDK20.65187687
105STK110.63868874
106WNK10.63821777
107CSNK1E0.63809990
108CAMK40.63227103
109BRD40.62368688
110CDC42BPA0.62327969
111CSNK1G10.61483067
112CCNB10.61376860
113CDK70.59750755
114AURKA0.59507713
115CDK90.58754461
116PRKCZ0.58575516
117MAP3K130.58441058
118CDK150.58296967
119CSNK1G20.57712291
120PRKCH0.57544358
121OXSR10.57360736
122FGFR10.57179261
123LATS20.56259376
124BUB10.56060808
125BMPR1B0.55954263
126CDK80.55875848
127PAK30.55135423
128GRK70.54529266
129PRKDC0.54130310
130PRKAA10.54077606
131TYRO30.53451963
132NUAK10.53226181
133CDK140.50539818
134CSNK1G30.50508179
135LMTK20.49901334
136CAMK2D0.49854691
137RPS6KA30.49423590
138PRKG10.48372011
139CDK11A0.47439577
140MTOR0.44937457
141MAPK100.44763805
142PRKCB0.44623167
143ICK0.44450878
144CSNK1D0.43718315
145BRAF0.42740292
146MELK0.41632004
147DYRK1B0.41588278
148ADRBK10.39019422
149GSK3B0.38681867
150CSNK1A1L0.38090614
151EIF2AK20.38030279
152PRKACA0.36570497
153CAMK1D0.35034815
154FYN0.33715726
155RPS6KA20.32597263
156ERBB20.32418608
157PRKCA0.31803242

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.30541036
2Synaptic vesicle cycle_Homo sapiens_hsa047213.01297299
3Phototransduction_Homo sapiens_hsa047442.83241754
4GABAergic synapse_Homo sapiens_hsa047272.81340086
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.79374784
6Circadian entrainment_Homo sapiens_hsa047132.73602546
7Morphine addiction_Homo sapiens_hsa050322.72653255
8Glutamatergic synapse_Homo sapiens_hsa047242.65561181
9Olfactory transduction_Homo sapiens_hsa047402.62475777
10Non-homologous end-joining_Homo sapiens_hsa034502.37854749
11Cell cycle_Homo sapiens_hsa041102.29614742
12Steroid biosynthesis_Homo sapiens_hsa001002.18795495
13Fanconi anemia pathway_Homo sapiens_hsa034602.18790904
14Basal transcription factors_Homo sapiens_hsa030222.14655565
15Long-term potentiation_Homo sapiens_hsa047202.09633759
16Amphetamine addiction_Homo sapiens_hsa050312.09229271
17Taste transduction_Homo sapiens_hsa047422.08943348
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.06747913
19Insulin secretion_Homo sapiens_hsa049112.01931260
20mRNA surveillance pathway_Homo sapiens_hsa030152.01851207
21Salivary secretion_Homo sapiens_hsa049702.00363079
22RNA transport_Homo sapiens_hsa030132.00164895
23Dopaminergic synapse_Homo sapiens_hsa047281.99890661
24Mismatch repair_Homo sapiens_hsa034301.90257133
25DNA replication_Homo sapiens_hsa030301.89133421
26Serotonergic synapse_Homo sapiens_hsa047261.87048623
27Cholinergic synapse_Homo sapiens_hsa047251.83637693
28Homologous recombination_Homo sapiens_hsa034401.81482576
29Renin secretion_Homo sapiens_hsa049241.73163929
30Hippo signaling pathway_Homo sapiens_hsa043901.70474206
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.65092668
32Calcium signaling pathway_Homo sapiens_hsa040201.62523654
33Cocaine addiction_Homo sapiens_hsa050301.61497701
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.60900567
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.60205465
36Spliceosome_Homo sapiens_hsa030401.59614285
37Long-term depression_Homo sapiens_hsa047301.55808621
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.52076530
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.51166757
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.50316620
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.48245917
42RNA degradation_Homo sapiens_hsa030181.47034754
43Base excision repair_Homo sapiens_hsa034101.46112390
44Oxytocin signaling pathway_Homo sapiens_hsa049211.43348051
45Gastric acid secretion_Homo sapiens_hsa049711.43023135
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.40857965
47Nucleotide excision repair_Homo sapiens_hsa034201.40802306
48Axon guidance_Homo sapiens_hsa043601.39525992
49Lysine degradation_Homo sapiens_hsa003101.37473609
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.36253917
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.34275100
52cAMP signaling pathway_Homo sapiens_hsa040241.33695969
53Type II diabetes mellitus_Homo sapiens_hsa049301.33137821
54Selenocompound metabolism_Homo sapiens_hsa004501.23853457
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23634679
56TGF-beta signaling pathway_Homo sapiens_hsa043501.21526669
57Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20187920
58Gap junction_Homo sapiens_hsa045401.16331465
59Propanoate metabolism_Homo sapiens_hsa006401.13085766
60Collecting duct acid secretion_Homo sapiens_hsa049661.12411354
61MicroRNAs in cancer_Homo sapiens_hsa052061.11466077
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11256368
63RNA polymerase_Homo sapiens_hsa030201.09438667
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.09435649
65Butanoate metabolism_Homo sapiens_hsa006501.07875141
66GnRH signaling pathway_Homo sapiens_hsa049121.05571220
67Adherens junction_Homo sapiens_hsa045201.05057679
68ErbB signaling pathway_Homo sapiens_hsa040121.00913218
69cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00104089
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.96852503
71Circadian rhythm_Homo sapiens_hsa047100.95387942
72Melanogenesis_Homo sapiens_hsa049160.93197203
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93184947
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84356229
75p53 signaling pathway_Homo sapiens_hsa041150.82954847
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82442541
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82148178
78Protein export_Homo sapiens_hsa030600.81935942
79Fatty acid biosynthesis_Homo sapiens_hsa000610.80398367
80Dilated cardiomyopathy_Homo sapiens_hsa054140.79805849
81Glioma_Homo sapiens_hsa052140.79285458
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.79006169
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.78384617
84Type I diabetes mellitus_Homo sapiens_hsa049400.78366550
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77823388
86Estrogen signaling pathway_Homo sapiens_hsa049150.76136698
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75765896
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75015083
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74834691
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73739304
91Prostate cancer_Homo sapiens_hsa052150.72949330
92Choline metabolism in cancer_Homo sapiens_hsa052310.72670852
93Vibrio cholerae infection_Homo sapiens_hsa051100.71623406
94MAPK signaling pathway_Homo sapiens_hsa040100.71560609
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69867434
96Pancreatic secretion_Homo sapiens_hsa049720.68941327
97Wnt signaling pathway_Homo sapiens_hsa043100.68439138
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68347044
99Fatty acid metabolism_Homo sapiens_hsa012120.67279899
100Thyroid cancer_Homo sapiens_hsa052160.66353846
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66042369
102AMPK signaling pathway_Homo sapiens_hsa041520.66014565
103Inositol phosphate metabolism_Homo sapiens_hsa005620.65818759
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65545904
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65116798
106Cardiac muscle contraction_Homo sapiens_hsa042600.64823970
107Dorso-ventral axis formation_Homo sapiens_hsa043200.64503736
108Pyruvate metabolism_Homo sapiens_hsa006200.63990295
109Tight junction_Homo sapiens_hsa045300.62698314
110Cysteine and methionine metabolism_Homo sapiens_hsa002700.62146852
111Ras signaling pathway_Homo sapiens_hsa040140.61438250
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60093194
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59587245
114Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58752666
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58567599
116Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54598869
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54387574
118FoxO signaling pathway_Homo sapiens_hsa040680.53530042
119Ovarian steroidogenesis_Homo sapiens_hsa049130.52551081
120Notch signaling pathway_Homo sapiens_hsa043300.52305048
121Oocyte meiosis_Homo sapiens_hsa041140.52141690
122Alcoholism_Homo sapiens_hsa050340.52104929
123Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50739729
124Endometrial cancer_Homo sapiens_hsa052130.50044696
125Rap1 signaling pathway_Homo sapiens_hsa040150.47825203
126Purine metabolism_Homo sapiens_hsa002300.47142027
127Rheumatoid arthritis_Homo sapiens_hsa053230.47139740
128Thyroid hormone synthesis_Homo sapiens_hsa049180.46434973
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.44715960
130Pyrimidine metabolism_Homo sapiens_hsa002400.44426227
131Chemokine signaling pathway_Homo sapiens_hsa040620.44385693
132Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44118797
133Biosynthesis of amino acids_Homo sapiens_hsa012300.43771485
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.42671342
135Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42176234
136Pathways in cancer_Homo sapiens_hsa052000.41648703
137Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39304715
138African trypanosomiasis_Homo sapiens_hsa051430.38470743
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38383484
140Colorectal cancer_Homo sapiens_hsa052100.37698970
141Hedgehog signaling pathway_Homo sapiens_hsa043400.36763155
142Mineral absorption_Homo sapiens_hsa049780.34929019
143Basal cell carcinoma_Homo sapiens_hsa052170.34510425
144Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34163157
145Glucagon signaling pathway_Homo sapiens_hsa049220.32808070
146mTOR signaling pathway_Homo sapiens_hsa041500.30921571
147Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28620151
148Sphingolipid metabolism_Homo sapiens_hsa006000.27120702
149Melanoma_Homo sapiens_hsa052180.26919093
150Autoimmune thyroid disease_Homo sapiens_hsa053200.26208138
151Endocytosis_Homo sapiens_hsa041440.24166950
152Non-small cell lung cancer_Homo sapiens_hsa052230.24065883
153Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.22436134

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