ZKSCAN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Kruppel C2H2-type zinc-finger family of proteins. This encoded protein may function as a transcription factor that regulates the expression of GABA type-A receptors in the brain. Transcripts from this gene have been shown to form stable and abundant circular RNAs. Elevated expression of this gene has been observed in gastric cancer and the encoded protein may stimulate migration and invasion of human gastric cancer cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.19074139
2presynaptic membrane assembly (GO:0097105)4.03429246
3neurotransmitter-gated ion channel clustering (GO:0072578)3.93278524
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.90504117
5negative regulation of dendrite morphogenesis (GO:0050774)3.88417976
6cellular glucuronidation (GO:0052695)3.70158626
7regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.63137056
8pyrimidine nucleobase catabolic process (GO:0006208)3.60879793
9glucuronate metabolic process (GO:0019585)3.60747872
10uronic acid metabolic process (GO:0006063)3.60747872
11histone H3-K4 trimethylation (GO:0080182)3.50975594
12metanephric mesenchyme development (GO:0072075)3.47484049
13negative regulation of dendrite development (GO:2000171)3.45138073
14presynaptic membrane organization (GO:0097090)3.41293795
15negative regulation of sodium ion transport (GO:0010766)3.40402448
16epithelial cilium movement (GO:0003351)3.39589135
17cilium movement (GO:0003341)3.36280663
18kidney mesenchyme development (GO:0072074)3.24318366
19nonmotile primary cilium assembly (GO:0035058)3.17981576
20postsynaptic membrane organization (GO:0001941)3.17515854
21auditory receptor cell differentiation (GO:0042491)3.13348072
22calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.13164162
23cilium or flagellum-dependent cell motility (GO:0001539)3.08143885
24dendritic spine morphogenesis (GO:0060997)3.06534313
25neural tube formation (GO:0001841)3.05441812
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.03839393
27nephron tubule morphogenesis (GO:0072078)3.02476489
28nephron epithelium morphogenesis (GO:0072088)3.02476489
29prostate gland growth (GO:0060736)3.02459396
30tryptophan metabolic process (GO:0006568)2.97281539
31complement activation, alternative pathway (GO:0006957)2.96193990
32renal tubule morphogenesis (GO:0061333)2.92547218
33exploration behavior (GO:0035640)2.92156681
34retinal ganglion cell axon guidance (GO:0031290)2.91820406
35nucleobase catabolic process (GO:0046113)2.89441522
36synaptic vesicle docking involved in exocytosis (GO:0016081)2.89409157
37synapse assembly (GO:0007416)2.88630647
38dentate gyrus development (GO:0021542)2.88310489
39axoneme assembly (GO:0035082)2.87769121
40cilium assembly (GO:0042384)2.85052446
41negative regulation of cytosolic calcium ion concentration (GO:0051481)2.84743865
42cilium organization (GO:0044782)2.81824495
43inner ear receptor cell differentiation (GO:0060113)2.80654990
44ketone body metabolic process (GO:1902224)2.80485059
45diterpenoid biosynthetic process (GO:0016102)2.80061738
46cell differentiation involved in kidney development (GO:0061005)2.79369388
47neuron cell-cell adhesion (GO:0007158)2.78278656
48midgut development (GO:0007494)2.75304934
49negative regulation of stem cell proliferation (GO:2000647)2.74722265
50tryptophan catabolic process (GO:0006569)2.73627386
51indole-containing compound catabolic process (GO:0042436)2.73627386
52indolalkylamine catabolic process (GO:0046218)2.73627386
53embryonic retina morphogenesis in camera-type eye (GO:0060059)2.72486607
54appendage development (GO:0048736)2.70466777
55limb development (GO:0060173)2.70466777
56glomerulus development (GO:0032835)2.68627247
57insulin-like growth factor receptor signaling pathway (GO:0048009)2.66888874
58limb bud formation (GO:0060174)2.66766412
59urea metabolic process (GO:0019627)2.65740173
60urea cycle (GO:0000050)2.65740173
61axonal fasciculation (GO:0007413)2.63231440
62cilium morphogenesis (GO:0060271)2.59551164
63auditory behavior (GO:0031223)2.58051644
64gamma-aminobutyric acid transport (GO:0015812)2.55503326
65regulation of axon guidance (GO:1902667)2.52444825
66mechanoreceptor differentiation (GO:0042490)2.52252583
67glycerophospholipid catabolic process (GO:0046475)2.50697088
68neurotransmitter catabolic process (GO:0042135)2.49600958
69lactate metabolic process (GO:0006089)2.49003552
70ganglion development (GO:0061548)2.48301394
71exogenous drug catabolic process (GO:0042738)2.47330874
72negative regulation of keratinocyte proliferation (GO:0010839)2.46874558
73eye photoreceptor cell differentiation (GO:0001754)2.45080817
74photoreceptor cell differentiation (GO:0046530)2.45080817
75gap junction assembly (GO:0016264)2.44725523
76regulation of protein activation cascade (GO:2000257)2.44455530
77central nervous system projection neuron axonogenesis (GO:0021952)2.44351280
78aromatic amino acid family catabolic process (GO:0009074)2.43171481
79interkinetic nuclear migration (GO:0022027)2.42964234
80positive regulation of muscle hypertrophy (GO:0014742)2.42807581
81positive regulation of cardiac muscle hypertrophy (GO:0010613)2.42807581
82regulation of cilium movement (GO:0003352)2.41082690
83neuronal stem cell maintenance (GO:0097150)2.40603299
84drug catabolic process (GO:0042737)2.40122424
85erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.40079818
86L-phenylalanine catabolic process (GO:0006559)2.40079818
87mechanosensory behavior (GO:0007638)2.40018583
88axonemal dynein complex assembly (GO:0070286)2.39895575
89cerebellar Purkinje cell differentiation (GO:0021702)2.39490342
90bile acid biosynthetic process (GO:0006699)2.39448605
91macroautophagy (GO:0016236)2.38668230
92negative regulation of fatty acid transport (GO:2000192)2.38133551
93inositol phosphate catabolic process (GO:0071545)2.36945101
94tyrosine metabolic process (GO:0006570)2.36372719
95detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.35608587
96smoothened signaling pathway (GO:0007224)2.34316265
97negative regulation of axon guidance (GO:1902668)2.34018062
98kidney morphogenesis (GO:0060993)2.33801289
99negative regulation of glycogen metabolic process (GO:0070874)2.32992815
100intraciliary transport (GO:0042073)2.32686759
101regulation of respiratory system process (GO:0044065)2.32356179
102regulation of complement activation (GO:0030449)2.30975670
103protein polyglutamylation (GO:0018095)2.30362721
104central nervous system neuron axonogenesis (GO:0021955)2.29319039
105cellular component assembly involved in morphogenesis (GO:0010927)2.29312885
106negative regulation of protein activation cascade (GO:2000258)2.29184802
107protein localization to cilium (GO:0061512)2.29105588
108positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.28555286
109dendrite morphogenesis (GO:0048813)2.28491571
110exocrine pancreas development (GO:0031017)2.27446507
111regulation of axon extension involved in axon guidance (GO:0048841)2.27443303
112vocalization behavior (GO:0071625)2.27380035
113photoreceptor cell maintenance (GO:0045494)2.26266834
114spinal cord motor neuron differentiation (GO:0021522)2.26195858
115homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.26123082
116regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.25476284
117protein localization to synapse (GO:0035418)2.24804984
118positive regulation of fatty acid beta-oxidation (GO:0032000)2.24549489
119ER overload response (GO:0006983)2.24522163
120phenylpropanoid metabolic process (GO:0009698)2.24107723
121hindbrain development (GO:0030902)2.23775070
122retina layer formation (GO:0010842)2.23571431
123anatomical structure arrangement (GO:0048532)2.23179431
124positive regulation of mesonephros development (GO:0061213)2.22848514
125cellular ketone body metabolic process (GO:0046950)2.22708889
126cornea development in camera-type eye (GO:0061303)2.21906092
127negative regulation of glycogen biosynthetic process (GO:0045719)2.21382017
128regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.21055302
129high-density lipoprotein particle remodeling (GO:0034375)2.20928516
130positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.20800347
131negative regulation of axon extension involved in axon guidance (GO:0048843)2.20718280
132establishment of protein localization to Golgi (GO:0072600)2.20469410
133indolalkylamine metabolic process (GO:0006586)2.20348478
134ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.19627453
135cell differentiation involved in metanephros development (GO:0072202)2.19547473
136neuron recognition (GO:0008038)2.18899792
137positive regulation of glycolytic process (GO:0045821)2.18729971
138regulation of bile acid biosynthetic process (GO:0070857)2.18700484
139positive regulation of glycogen biosynthetic process (GO:0045725)2.18662024
140detection of light stimulus involved in sensory perception (GO:0050962)2.18152917
141detection of light stimulus involved in visual perception (GO:0050908)2.18152917
142regulation of mesonephros development (GO:0061217)2.17161613
143sympathetic nervous system development (GO:0048485)2.16755545
144long-term synaptic potentiation (GO:0060291)2.16332264
145positive regulation of cardiac muscle cell differentiation (GO:2000727)2.16293563
146synapse organization (GO:0050808)2.15929058
147negative regulation of systemic arterial blood pressure (GO:0003085)2.14851882
148protein import into peroxisome matrix (GO:0016558)2.14804648
149regulation of short-term neuronal synaptic plasticity (GO:0048172)2.14493098
150positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.14010667
151pancreas development (GO:0031016)2.13340860
152inner ear receptor cell development (GO:0060119)2.13236678
153negative regulation of astrocyte differentiation (GO:0048712)2.13090438
154microtubule bundle formation (GO:0001578)2.12773554
155startle response (GO:0001964)2.12530735
156regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.12183632
157phospholipid homeostasis (GO:0055091)2.12110085
158cell migration in hindbrain (GO:0021535)2.11996078
159transmission of nerve impulse (GO:0019226)2.11414174
160neuronal action potential (GO:0019228)2.10323403
161L-fucose metabolic process (GO:0042354)2.10315502
162L-fucose catabolic process (GO:0042355)2.10315502
163fucose catabolic process (GO:0019317)2.10315502
164cranial nerve development (GO:0021545)2.08890443
165endocrine pancreas development (GO:0031018)2.08096670
166spinal cord development (GO:0021510)2.08000848
167negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.07983524
168negative regulation of translation, ncRNA-mediated (GO:0040033)2.07983524
169regulation of translation, ncRNA-mediated (GO:0045974)2.07983524
170astrocyte differentiation (GO:0048708)2.06916859
171olfactory bulb development (GO:0021772)2.06361514
172cerebral cortex radially oriented cell migration (GO:0021799)2.05422840
173negative regulation of oligodendrocyte differentiation (GO:0048715)2.04269116

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse5.08569753
2GBX2_23144817_ChIP-Seq_PC3_Human4.03474658
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.16541827
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.08502223
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.90490186
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.81976270
7ZNF274_21170338_ChIP-Seq_K562_Hela2.61614123
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.45922079
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.20433456
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.16566607
11TAF15_26573619_Chip-Seq_HEK293_Human2.14742604
12PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.04336771
13PIAS1_25552417_ChIP-Seq_VCAP_Human2.04252166
14P300_19829295_ChIP-Seq_ESCs_Human1.99902772
15SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.96603708
16EZH2_22144423_ChIP-Seq_EOC_Human1.95887650
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.95528850
18ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94377447
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.91640791
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90557755
21AR_21572438_ChIP-Seq_LNCaP_Human1.87522243
22SMAD4_21799915_ChIP-Seq_A2780_Human1.86891207
23ZNF217_24962896_ChIP-Seq_MCF-7_Human1.84569766
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78549208
25FUS_26573619_Chip-Seq_HEK293_Human1.76137903
26WT1_19549856_ChIP-ChIP_CCG9911_Human1.74882698
27VDR_22108803_ChIP-Seq_LS180_Human1.70866159
28* ARNT_22903824_ChIP-Seq_MCF-7_Human1.67012348
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.63561908
30EWS_26573619_Chip-Seq_HEK293_Human1.62059795
31REST_21632747_ChIP-Seq_MESCs_Mouse1.61460066
32SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.61447598
33* AHR_22903824_ChIP-Seq_MCF-7_Human1.59121736
34SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.56745945
35OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56541893
36TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53885919
37IGF1R_20145208_ChIP-Seq_DFB_Human1.50980859
38TP53_16413492_ChIP-PET_HCT116_Human1.50118918
39ESR1_20079471_ChIP-ChIP_T-47D_Human1.49030305
40DROSHA_22980978_ChIP-Seq_HELA_Human1.48813337
41STAT3_23295773_ChIP-Seq_U87_Human1.47143534
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46762561
43TP53_18474530_ChIP-ChIP_U2OS_Human1.45673331
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45377614
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.44225249
46NR3C1_21868756_ChIP-Seq_MCF10A_Human1.44111120
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.43853507
48EZH2_27304074_Chip-Seq_ESCs_Mouse1.43842969
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43496913
50* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43417038
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.43111455
52SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.43098539
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42883494
54TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.42057986
55AR_25329375_ChIP-Seq_VCAP_Human1.41276757
56TCF4_18268006_ChIP-ChIP_LS174T_Human1.38138250
57BCAT_22108803_ChIP-Seq_LS180_Human1.37353507
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36885447
59JARID2_20064375_ChIP-Seq_MESCs_Mouse1.36368967
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.32747236
61EP300_21415370_ChIP-Seq_HL-1_Mouse1.32439809
62SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.32363675
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31999460
64BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31586168
65ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.30613916
66NRF2_20460467_ChIP-Seq_MEFs_Mouse1.30471479
67NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.30471479
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.30422715
69NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.29603171
70CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28883981
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28069749
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28069749
73TCF4_23295773_ChIP-Seq_U87_Human1.26638329
74CBP_20019798_ChIP-Seq_JUKART_Human1.26066388
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26066388
76NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.25573150
77EZH2_27294783_Chip-Seq_ESCs_Mouse1.25073018
78E2F1_18555785_Chip-Seq_ESCs_Mouse1.23916915
79RNF2_18974828_ChIP-Seq_MESCs_Mouse1.23039069
80EZH2_18974828_ChIP-Seq_MESCs_Mouse1.23039069
81SOX2_21211035_ChIP-Seq_LN229_Gbm1.22676071
82EGR1_23403033_ChIP-Seq_LIVER_Mouse1.22478698
83ER_23166858_ChIP-Seq_MCF-7_Human1.21804266
84* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21560058
85TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21203489
86NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19714474
87PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18910809
88RNF2_27304074_Chip-Seq_NSC_Mouse1.17682602
89SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17247019
90REST_18959480_ChIP-ChIP_MESCs_Mouse1.16680372
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16481692
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15834944
93STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.14876507
94SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13914733
95CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.12582855
96P53_22387025_ChIP-Seq_ESCs_Mouse1.12325565
97FLI1_27457419_Chip-Seq_LIVER_Mouse1.11413994
98CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11196122
99CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10229941
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10005378
101YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09670730
102RUNX2_22187159_ChIP-Seq_PCA_Human1.08463434
103TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.07872886
104JARID2_20075857_ChIP-Seq_MESCs_Mouse1.07382596
105TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07140969
106TCF4_22108803_ChIP-Seq_LS180_Human1.07036107
107WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06850719
108RNF2_27304074_Chip-Seq_ESCs_Mouse1.06748828
109* AR_19668381_ChIP-Seq_PC3_Human1.06152191
110CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05887640
111CMYC_18555785_Chip-Seq_ESCs_Mouse1.05430498
112MTF2_20144788_ChIP-Seq_MESCs_Mouse1.05005685
113POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03994522
114LXR_22158963_ChIP-Seq_LIVER_Mouse1.03910467
115* FOXA2_19822575_ChIP-Seq_HepG2_Human1.03028117
116KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02633189
117KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00821404
118FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00659275
119PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99942761
120LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99799183
121PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98842095
122* TAL1_26923725_Chip-Seq_HPCs_Mouse0.97442488
123RING1B_27294783_Chip-Seq_ESCs_Mouse0.96824635

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia3.73961300
2MP0009697_abnormal_copulation3.15056173
3MP0009780_abnormal_chondrocyte_physiolo2.92444722
4MP0005646_abnormal_pituitary_gland2.87378030
5MP0003787_abnormal_imprinting2.84527575
6MP0002139_abnormal_hepatobiliary_system2.77606803
7MP0001984_abnormal_olfaction2.75925337
8MP0003122_maternal_imprinting2.73450675
9MP0003252_abnormal_bile_duct2.63381753
10MP0005085_abnormal_gallbladder_physiolo2.57193019
11MP0005365_abnormal_bile_salt2.41681966
12MP0005360_urolithiasis2.24052946
13MP0008875_abnormal_xenobiotic_pharmacok2.19191723
14MP0005248_abnormal_Harderian_gland2.16829450
15MP0005171_absent_coat_pigmentation2.14275012
16MP0009053_abnormal_anal_canal2.11411487
17MP0001188_hyperpigmentation2.03320666
18MP0000566_synostosis2.02960269
19MP0002909_abnormal_adrenal_gland2.01383929
20MP0000569_abnormal_digit_pigmentation2.00329839
21MP0004043_abnormal_pH_regulation1.90668165
22MP0005499_abnormal_olfactory_system1.82903000
23MP0005394_taste/olfaction_phenotype1.82903000
24MP0002638_abnormal_pupillary_reflex1.82353861
25MP0008789_abnormal_olfactory_epithelium1.80868026
26MP0003121_genomic_imprinting1.80211164
27MP0005367_renal/urinary_system_phenotyp1.75057766
28MP0000516_abnormal_urinary_system1.75057766
29MP0003283_abnormal_digestive_organ1.73649316
30MP0003942_abnormal_urinary_system1.71193226
31MP0003136_yellow_coat_color1.69789748
32MP0002876_abnormal_thyroid_physiology1.66998545
33MP0009046_muscle_twitch1.61870068
34MP0002938_white_spotting1.57633824
35MP0004133_heterotaxia1.55451161
36MP0003943_abnormal_hepatobiliary_system1.53266795
37MP0004885_abnormal_endolymph1.51941849
38MP0002822_catalepsy1.48198886
39MP0000955_abnormal_spinal_cord1.47831908
40MP0005503_abnormal_tendon_morphology1.46936787
41MP0003880_abnormal_central_pattern1.46350031
42MP0000778_abnormal_nervous_system1.43805799
43MP0006072_abnormal_retinal_apoptosis1.39418074
44MP0002928_abnormal_bile_duct1.38993777
45MP0002653_abnormal_ependyma_morphology1.37974844
46MP0002249_abnormal_larynx_morphology1.37643535
47MP0002272_abnormal_nervous_system1.31864565
48MP0000383_abnormal_hair_follicle1.31245911
49MP0000631_abnormal_neuroendocrine_gland1.31085352
50MP0010368_abnormal_lymphatic_system1.30224973
51MP0010030_abnormal_orbit_morphology1.29802811
52MP0005408_hypopigmentation1.27763839
53MP0005423_abnormal_somatic_nervous1.27565882
54MP0009384_cardiac_valve_regurgitation1.26833923
55MP0004859_abnormal_synaptic_plasticity1.26788146
56MP0005253_abnormal_eye_physiology1.25274730
57MP0009250_abnormal_appendicular_skeleto1.25254215
58MP0000372_irregular_coat_pigmentation1.24239378
59MP0001270_distended_abdomen1.23757699
60MP0010386_abnormal_urinary_bladder1.22678713
61MP0005409_darkened_coat_color1.20985819
62MP0003385_abnormal_body_wall1.20491170
63MP0002064_seizures1.20302210
64MP0002233_abnormal_nose_morphology1.17710164
65MP0004142_abnormal_muscle_tone1.16319777
66MP0001968_abnormal_touch/_nociception1.14718971
67MP0004924_abnormal_behavior1.14699544
68MP0005386_behavior/neurological_phenoty1.14699544
69MP0004134_abnormal_chest_morphology1.14636966
70MP0002736_abnormal_nociception_after1.14280404
71MP0006276_abnormal_autonomic_nervous1.14063524
72MP0005187_abnormal_penis_morphology1.13891484
73MP0004270_analgesia1.12164436
74MP0001177_atelectasis1.10916997
75MP0002234_abnormal_pharynx_morphology1.10735527
76MP0000678_abnormal_parathyroid_gland1.10071375
77MP0003183_abnormal_peptide_metabolism1.09099361
78MP0005220_abnormal_exocrine_pancreas1.08702604
79MP0001502_abnormal_circadian_rhythm1.08333493
80MP0000534_abnormal_ureter_morphology1.08006230
81MP0005647_abnormal_sex_gland1.07734642
82MP0010678_abnormal_skin_adnexa1.07607733
83MP0003935_abnormal_craniofacial_develop1.06863138
84MP0002063_abnormal_learning/memory/cond1.05776619
85MP0002557_abnormal_social/conspecific_i1.05288549
86MP0002882_abnormal_neuron_morphology1.04754763
87MP0003937_abnormal_limbs/digits/tail_de1.04071103
88MP0001919_abnormal_reproductive_system1.02783085
89MP0005551_abnormal_eye_electrophysiolog1.02458502
90MP0002102_abnormal_ear_morphology1.00543613
91MP0001944_abnormal_pancreas_morphology0.99215225
92MP0003938_abnormal_ear_development0.98863893
93MP0003890_abnormal_embryonic-extraembry0.98396420
94MP0002282_abnormal_trachea_morphology0.98250062
95MP0000538_abnormal_urinary_bladder0.97790648
96MP0002751_abnormal_autonomic_nervous0.97753427
97MP0008877_abnormal_DNA_methylation0.97451184
98MP0004264_abnormal_extraembryonic_tissu0.97113420
99MP0001485_abnormal_pinna_reflex0.97103378
100MP0002160_abnormal_reproductive_system0.96723398
101MP0002752_abnormal_somatic_nervous0.94589388
102MP0002734_abnormal_mechanical_nocicepti0.94581508
103MP0003115_abnormal_respiratory_system0.94490467
104MP0010329_abnormal_lipoprotein_level0.94062494
105MP0002152_abnormal_brain_morphology0.92820019
106MP0001986_abnormal_taste_sensitivity0.91948803
107MP0005389_reproductive_system_phenotype0.91671888
108MP0003635_abnormal_synaptic_transmissio0.91583962
109MP0005174_abnormal_tail_pigmentation0.91439429
110MP0000049_abnormal_middle_ear0.90095066
111MP0001756_abnormal_urination0.89916497
112MP0000026_abnormal_inner_ear0.89341222
113MP0005195_abnormal_posterior_eye0.88385163
114MP0009745_abnormal_behavioral_response0.87995630
115MP0001529_abnormal_vocalization0.87188401
116MP0006292_abnormal_olfactory_placode0.86012665
117MP0002138_abnormal_hepatobiliary_system0.85856718
118MP0001764_abnormal_homeostasis0.85646002
119MP0003868_abnormal_feces_composition0.85514327
120MP0003861_abnormal_nervous_system0.85293546
121MP0001324_abnormal_eye_pigmentation0.84847601
122MP0003195_calcinosis0.84680287
123MP0003755_abnormal_palate_morphology0.84561848
124MP0002572_abnormal_emotion/affect_behav0.84163787
125MP0001970_abnormal_pain_threshold0.83445353
126MP0000639_abnormal_adrenal_gland0.83164669
127MP0005645_abnormal_hypothalamus_physiol0.82596394
128MP0001286_abnormal_eye_development0.81752230
129MP0002735_abnormal_chemical_nociception0.80485755
130MP0001299_abnormal_eye_distance/0.80109644
131MP0005391_vision/eye_phenotype0.79643495
132MP0002184_abnormal_innervation0.78243915
133MP0001486_abnormal_startle_reflex0.77909986
134MP0003632_abnormal_nervous_system0.77800390
135MP0002067_abnormal_sensory_capabilities0.77421694
136MP0005379_endocrine/exocrine_gland_phen0.77342845
137MP0003123_paternal_imprinting0.74774869
138MP0009379_abnormal_foot_pigmentation0.73449078
139MP0000427_abnormal_hair_cycle0.72764050
140MP0003011_delayed_dark_adaptation0.72502739
141MP0001879_abnormal_lymphatic_vessel0.71437209
142MP0000163_abnormal_cartilage_morphology0.70757790
143MP0002109_abnormal_limb_morphology0.70533786
144MP0002166_altered_tumor_susceptibility0.69772387

Predicted human phenotypes

RankGene SetZ-score
1Hepatoblastoma (HP:0002884)4.22201716
2Papillary thyroid carcinoma (HP:0002895)3.66094349
3Pancreatic cysts (HP:0001737)3.53688055
4Pancreatic fibrosis (HP:0100732)3.39887431
5Neoplasm of the adrenal cortex (HP:0100641)3.32412835
6Nephronophthisis (HP:0000090)3.31662270
7Vitreoretinal degeneration (HP:0000655)3.19414927
8Volvulus (HP:0002580)3.14844404
9Neoplasm of the tracheobronchial system (HP:0100552)3.12778353
10Chronic hepatic failure (HP:0100626)3.12626147
11Submucous cleft hard palate (HP:0000176)3.12373285
12Asymmetry of the thorax (HP:0001555)3.06643732
13Absent eyebrow (HP:0002223)3.01094203
14Abnormality of the renal medulla (HP:0100957)2.99945354
15Chorioretinal atrophy (HP:0000533)2.97045835
16Molar tooth sign on MRI (HP:0002419)2.96707311
17Abnormality of midbrain morphology (HP:0002418)2.96707311
18Alveolar cell carcinoma (HP:0006519)2.96456089
19Hyperventilation (HP:0002883)2.95100279
20Hypothermia (HP:0002045)2.93357037
21Cystic liver disease (HP:0006706)2.85879502
22Blue irides (HP:0000635)2.82390060
23Abnormality of the renal cortex (HP:0011035)2.80114434
24Febrile seizures (HP:0002373)2.77399929
25Thyroid carcinoma (HP:0002890)2.75312703
26Tubular atrophy (HP:0000092)2.68316557
27Conjugated hyperbilirubinemia (HP:0002908)2.63815254
28Abnormal respiratory epithelium morphology (HP:0012253)2.60678577
29Abnormal respiratory motile cilium morphology (HP:0005938)2.60678577
30Short 4th metacarpal (HP:0010044)2.60487134
31Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.60487134
32Tubulointerstitial nephritis (HP:0001970)2.60002302
33Abnormality of the nasal septum (HP:0000419)2.54354959
34Neoplasm of the adrenal gland (HP:0100631)2.48482609
35Midline defect of the nose (HP:0004122)2.43998649
36Abnormal ciliary motility (HP:0012262)2.41485111
37Absent/shortened dynein arms (HP:0200106)2.40722508
38Dynein arm defect of respiratory motile cilia (HP:0012255)2.40722508
39Enlarged kidneys (HP:0000105)2.38602680
40Occipital encephalocele (HP:0002085)2.31805214
41Abnormal hair whorl (HP:0010721)2.31182619
42Hemiparesis (HP:0001269)2.29897209
43Protruding tongue (HP:0010808)2.24342540
44Fibular hypoplasia (HP:0003038)2.24209436
45Postaxial foot polydactyly (HP:0001830)2.20923272
46Atonic seizures (HP:0010819)2.19914083
47Progressive sensorineural hearing impairment (HP:0000408)2.19399894
48Polydipsia (HP:0001959)2.17198528
49Abnormal drinking behavior (HP:0030082)2.17198528
50Abnormality of incisor morphology (HP:0011063)2.17089994
51Postaxial hand polydactyly (HP:0001162)2.16382983
52Truncal obesity (HP:0001956)2.16371636
53Complement deficiency (HP:0004431)2.14461976
54Polyphagia (HP:0002591)2.13730502
55Hypochromic microcytic anemia (HP:0004840)2.12971012
56Facial shape deformation (HP:0011334)2.12805296
57Potter facies (HP:0002009)2.12805296
58Broad-based gait (HP:0002136)2.12713543
59Neoplasm of the liver (HP:0002896)2.10828575
60Tubulointerstitial abnormality (HP:0001969)2.10429185
61Absent eyelashes (HP:0000561)2.10199355
62Nephrogenic diabetes insipidus (HP:0009806)2.09506847
63Abnormal respiratory motile cilium physiology (HP:0012261)2.07262155
64EEG with generalized epileptiform discharges (HP:0011198)2.05723609
65Hypsarrhythmia (HP:0002521)2.05636111
66Stomach cancer (HP:0012126)2.05450355
67Fair hair (HP:0002286)2.03785396
68Specific learning disability (HP:0001328)2.03090950
69Cone-rod dystrophy (HP:0000548)2.02443601
70Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.02285648
71Epileptic encephalopathy (HP:0200134)2.01557468
72Epileptiform EEG discharges (HP:0011182)2.01411829
73Absent speech (HP:0001344)2.00848416
74Cutaneous finger syndactyly (HP:0010554)1.98364907
75Gait imbalance (HP:0002141)1.97654924
76Abnormality of the 4th metacarpal (HP:0010012)1.97507699
77Poor coordination (HP:0002370)1.97434907
78Macroorchidism (HP:0000053)1.97009043
79Lissencephaly (HP:0001339)1.96415800
80Gaze-evoked nystagmus (HP:0000640)1.95859296
81Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.95299905
82Pachygyria (HP:0001302)1.95107618
83Renal hypoplasia (HP:0000089)1.93989287
84Neonatal hypoglycemia (HP:0001998)1.92986706
85Progressive cerebellar ataxia (HP:0002073)1.91783432
86Congenital primary aphakia (HP:0007707)1.91486439
87Focal seizures (HP:0007359)1.90130489
88Intestinal atresia (HP:0011100)1.90037480
89Abnormality of the aortic arch (HP:0012303)1.89864621
90Generalized hypopigmentation of hair (HP:0011358)1.89062581
91Aplasia/Hypoplasia of the tongue (HP:0010295)1.88884907
92Congenital hepatic fibrosis (HP:0002612)1.87160772
93True hermaphroditism (HP:0010459)1.86941525
94Rhinitis (HP:0012384)1.86557450
95Short foot (HP:0001773)1.86197268
96Pigmentary retinal degeneration (HP:0001146)1.85069920
97Germ cell neoplasia (HP:0100728)1.84093338
98Labial hypoplasia (HP:0000066)1.82937431
99Renal cortical cysts (HP:0000803)1.82600607
100Ketoacidosis (HP:0001993)1.78911706
101Aplasia/Hypoplasia of the lens (HP:0008063)1.78845264
102Medial flaring of the eyebrow (HP:0010747)1.78462456
103Aqueductal stenosis (HP:0002410)1.77661442
104Exostoses (HP:0100777)1.77459584
105Drooling (HP:0002307)1.76289896
106Excessive salivation (HP:0003781)1.76289896
107Genetic anticipation (HP:0003743)1.76051252
108Ketosis (HP:0001946)1.76020422
109Morphological abnormality of the middle ear (HP:0008609)1.75997436
110Abnormal biliary tract physiology (HP:0012439)1.75476670
111Bile duct proliferation (HP:0001408)1.75476670
112Arthropathy (HP:0003040)1.74881424
113Cutaneous syndactyly (HP:0012725)1.74777729
114Abnormality of the ischium (HP:0003174)1.74416918
115Proximal tubulopathy (HP:0000114)1.74413483
116Exotropia (HP:0000577)1.73420196
117Hypoplastic ischia (HP:0003175)1.71992314
118Pheochromocytoma (HP:0002666)1.71419664
119Abnormality of the diencephalon (HP:0010662)1.70751458
120Vaginal atresia (HP:0000148)1.70690919
121Hip dysplasia (HP:0001385)1.70446126
122Genital tract atresia (HP:0001827)1.70207099
123Tented upper lip vermilion (HP:0010804)1.69613947
124Agitation (HP:0000713)1.68831695
125Furrowed tongue (HP:0000221)1.68458753
126Prominent nasal bridge (HP:0000426)1.68412801
127Focal motor seizures (HP:0011153)1.68098288
128Neoplasm of the lung (HP:0100526)1.68091318
129Male pseudohermaphroditism (HP:0000037)1.67235845
130Type II lissencephaly (HP:0007260)1.67057570
131Tubulointerstitial fibrosis (HP:0005576)1.66615032
132Hepatocellular carcinoma (HP:0001402)1.66210907
133Deep philtrum (HP:0002002)1.65696669
134Narrow forehead (HP:0000341)1.65229488
135Micropenis (HP:0000054)1.65092032
136Large for gestational age (HP:0001520)1.64947031
137Scanning speech (HP:0002168)1.63247183
138Aplasia/Hypoplasia of the fibula (HP:0006492)1.63023602
139Widely spaced teeth (HP:0000687)1.62995160
140Renal tubular acidosis (HP:0001947)1.62835459
141Epidermoid cyst (HP:0200040)1.62086733
142Sclerocornea (HP:0000647)1.61509001
143Anencephaly (HP:0002323)1.61086906
144Meningioma (HP:0002858)1.60630570
145Abnormal pancreas size (HP:0012094)1.59972910
146Anophthalmia (HP:0000528)1.59889654
147Embryonal neoplasm (HP:0002898)1.59848732
148Dyschromatopsia (HP:0007641)1.58804465
149Subacute progressive viral hepatitis (HP:0006572)1.58718811
150Smooth philtrum (HP:0000319)1.58289488
151Broad foot (HP:0001769)1.57574618
152Abnormality of the intervertebral disk (HP:0005108)1.57321757
153Heterochromia iridis (HP:0001100)1.55340192
154Decreased testicular size (HP:0008734)1.55157892
155Prolonged partial thromboplastin time (HP:0003645)1.55095691
156Long clavicles (HP:0000890)1.54718168
157Deep venous thrombosis (HP:0002625)1.54354615
158Omphalocele (HP:0001539)1.54333957
159Narrow nasal bridge (HP:0000446)1.54324677
160Scrotal hypoplasia (HP:0000046)1.54214466
161Downturned corners of mouth (HP:0002714)1.50918778
162Hypoglycemic seizures (HP:0002173)1.50858167
163Obsessive-compulsive behavior (HP:0000722)1.50721046
164Overgrowth (HP:0001548)1.50322599
165Accelerated skeletal maturation (HP:0005616)1.48817990
166Embryonal renal neoplasm (HP:0011794)1.48794247
167Urethral obstruction (HP:0000796)1.48346570

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.93993679
2FRK4.07994647
3AKT33.60733073
4SGK23.51788779
5NUAK13.47953064
6SGK32.61165828
7MAP4K22.60151160
8PIK3CA2.53554002
9SGK2232.43248283
10SGK4942.43248283
11SIK32.34323776
12STK38L2.20387565
13WNK42.01978353
14INSRR1.84168424
15FGFR21.81702666
16STK391.80735955
17PRPF4B1.80364076
18MAP2K71.74038207
19ERBB31.70572052
20EPHA31.68880849
21LATS11.66928042
22PAK31.64777873
23MAP3K41.62318894
24PINK11.61868354
25ZAK1.55804892
26MAPK131.54132459
27NEK61.48545993
28MAPK151.43849032
29NTRK31.31994573
30PLK21.28455047
31EPHB21.26514835
32NEK91.25856329
33EPHA41.24692497
34GRK11.23100026
35CDK81.16790185
36PNCK1.16745031
37FGFR31.15436106
38MARK11.13567619
39DYRK21.11177385
40MKNK21.10318544
41BMPR1B1.09904450
42SIK21.09769267
43YES11.06293088
44RPS6KB11.06096422
45CSNK1G21.01860263
46MAP3K121.01709825
47DAPK20.98945877
48WNK30.96305100
49CCNB10.93829210
50MAP3K20.92629482
51TEC0.88280820
52MKNK10.87892837
53SRPK10.87447544
54ADRBK20.86142003
55PLK30.86125147
56CSNK1G30.84638909
57ACVR1B0.84482582
58DMPK0.83246111
59PRKAA10.81636147
60MINK10.81203120
61KSR10.81036560
62MAP3K70.80462511
63NLK0.80415698
64BCR0.76561581
65FER0.75809610
66PHKG20.75788726
67PHKG10.75788726
68RPS6KA20.75261510
69SIK10.74052798
70MAP2K40.73897707
71SGK10.73429779
72TNIK0.73004315
73TGFBR10.70520964
74IRAK10.69856000
75WNK10.69737499
76PKN20.67631613
77ERBB20.67139814
78BRD40.64132689
79TSSK60.63562925
80PRKAA20.63189476
81PRKD30.63166081
82CAMK1G0.62459145
83FGFR40.62373778
84RET0.62009544
85CDK50.61487330
86PIK3CG0.61085760
87ERBB40.60010502
88CHUK0.59807347
89CDK30.55273292
90PRKCE0.54108458
91GRK70.53687628
92CAMK40.53327204
93BMPR20.52603853
94ROCK10.51640659
95ICK0.50868647
96STK30.50686568
97STK110.49982632
98PRKCH0.49613690
99OXSR10.49206097
100PRKCG0.47585862
101CSNK1E0.47339979
102TYRO30.46928358
103CSNK1A10.44897270
104STK380.44387691
105CSNK1D0.43924810
106MAPKAPK30.42388222
107NTRK20.42021424
108CAMK1D0.41115037
109PRKACB0.40956653
110LMTK20.40660336
111EEF2K0.40572722
112UHMK10.40259189
113MYLK0.40125251
114NTRK10.40041226
115RPS6KA30.38435732
116PRKACA0.38161558
117CSNK1A1L0.38068189
118DYRK30.38047006
119CAMKK20.37767025
120DDR20.37027701
121STK240.36950113
122CSNK1G10.34390556
123PRKG10.31808875
124PRKCZ0.31597662
125PDGFRB0.31506941
126FGFR10.31300433
127ADRBK10.31250236
128TAOK30.31045413
129DYRK1B0.30719948
130PDGFRA0.30683582
131MAPK70.30040918
132DAPK10.29795237
133RAF10.29388220
134ILK0.29367991
135EIF2AK20.29154363
136PRKCB0.28093969
137DYRK1A0.27624406
138PDK30.27508520
139PDK40.27508520
140MAP3K60.26650386
141TAOK20.26201635

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.91291215
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.66016591
3Sulfur metabolism_Homo sapiens_hsa009202.49757054
4Butanoate metabolism_Homo sapiens_hsa006502.31896204
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.15460297
6Nicotine addiction_Homo sapiens_hsa050332.11819217
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.02051776
8Phototransduction_Homo sapiens_hsa047441.98145623
9Steroid hormone biosynthesis_Homo sapiens_hsa001401.79578778
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.78100031
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.75390908
12Endometrial cancer_Homo sapiens_hsa052131.69909379
13Retinol metabolism_Homo sapiens_hsa008301.67677241
14Complement and coagulation cascades_Homo sapiens_hsa046101.67579047
15Linoleic acid metabolism_Homo sapiens_hsa005911.63861160
16Fatty acid degradation_Homo sapiens_hsa000711.56915983
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.54107666
18Histidine metabolism_Homo sapiens_hsa003401.53398886
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.51034639
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48269271
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.42812101
22Tryptophan metabolism_Homo sapiens_hsa003801.37417340
23Pyruvate metabolism_Homo sapiens_hsa006201.31186713
24Chemical carcinogenesis_Homo sapiens_hsa052041.31134553
25Steroid biosynthesis_Homo sapiens_hsa001001.26798719
26Tyrosine metabolism_Homo sapiens_hsa003501.26433814
27Arginine biosynthesis_Homo sapiens_hsa002201.25837143
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.25771388
29Starch and sucrose metabolism_Homo sapiens_hsa005001.25375442
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23291936
31Olfactory transduction_Homo sapiens_hsa047401.22848391
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.21388681
33Caffeine metabolism_Homo sapiens_hsa002321.21150444
34Synaptic vesicle cycle_Homo sapiens_hsa047211.20598872
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.16605547
36Circadian rhythm_Homo sapiens_hsa047101.14461927
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13090478
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.09647938
39Peroxisome_Homo sapiens_hsa041461.09088562
40Circadian entrainment_Homo sapiens_hsa047131.08010453
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07925301
42Fatty acid metabolism_Homo sapiens_hsa012121.07559625
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07334484
44Insulin secretion_Homo sapiens_hsa049111.06844950
45Lysine degradation_Homo sapiens_hsa003101.05825330
46Propanoate metabolism_Homo sapiens_hsa006401.03866754
47Ether lipid metabolism_Homo sapiens_hsa005651.02809267
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.02636772
49Adherens junction_Homo sapiens_hsa045201.02078691
50Axon guidance_Homo sapiens_hsa043601.00614092
51Cholinergic synapse_Homo sapiens_hsa047250.99793366
52Melanoma_Homo sapiens_hsa052180.98998871
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.97381847
54ABC transporters_Homo sapiens_hsa020100.95182255
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.94802378
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94605832
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.94555093
58Taste transduction_Homo sapiens_hsa047420.92188868
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.90949833
60Nitrogen metabolism_Homo sapiens_hsa009100.89942438
61Long-term depression_Homo sapiens_hsa047300.89301296
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88914978
63Morphine addiction_Homo sapiens_hsa050320.87925499
64Amphetamine addiction_Homo sapiens_hsa050310.87172260
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86515071
66GABAergic synapse_Homo sapiens_hsa047270.85638224
67Hedgehog signaling pathway_Homo sapiens_hsa043400.84617783
68Dopaminergic synapse_Homo sapiens_hsa047280.84527520
69Renin secretion_Homo sapiens_hsa049240.84066453
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81839791
71TGF-beta signaling pathway_Homo sapiens_hsa043500.80707383
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80389088
73Salivary secretion_Homo sapiens_hsa049700.80131565
74Type II diabetes mellitus_Homo sapiens_hsa049300.79664051
75Fatty acid biosynthesis_Homo sapiens_hsa000610.79069718
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72917968
77Long-term potentiation_Homo sapiens_hsa047200.72909833
78Protein export_Homo sapiens_hsa030600.72583374
79Bile secretion_Homo sapiens_hsa049760.70788587
80Selenocompound metabolism_Homo sapiens_hsa004500.69983346
81Thyroid hormone synthesis_Homo sapiens_hsa049180.69850928
82Dorso-ventral axis formation_Homo sapiens_hsa043200.69689590
83Insulin resistance_Homo sapiens_hsa049310.69417106
84Staphylococcus aureus infection_Homo sapiens_hsa051500.69346171
85N-Glycan biosynthesis_Homo sapiens_hsa005100.69262286
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67663769
87Basal cell carcinoma_Homo sapiens_hsa052170.67577643
88Collecting duct acid secretion_Homo sapiens_hsa049660.67282914
89Fat digestion and absorption_Homo sapiens_hsa049750.67102598
90AMPK signaling pathway_Homo sapiens_hsa041520.66273699
91Colorectal cancer_Homo sapiens_hsa052100.65756495
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65394461
93Glucagon signaling pathway_Homo sapiens_hsa049220.64963932
94Glutamatergic synapse_Homo sapiens_hsa047240.64923958
95Glioma_Homo sapiens_hsa052140.64766943
96Cocaine addiction_Homo sapiens_hsa050300.64646979
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64540360
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62337678
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61916661
100ErbB signaling pathway_Homo sapiens_hsa040120.60885043
101Prostate cancer_Homo sapiens_hsa052150.60583105
102Glycerolipid metabolism_Homo sapiens_hsa005610.58272330
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58215814
104Hippo signaling pathway_Homo sapiens_hsa043900.57216621
105beta-Alanine metabolism_Homo sapiens_hsa004100.57103152
106Wnt signaling pathway_Homo sapiens_hsa043100.56066072
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55743453
108Tight junction_Homo sapiens_hsa045300.54883395
109PPAR signaling pathway_Homo sapiens_hsa033200.54473599
110Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54318045
111Cyanoamino acid metabolism_Homo sapiens_hsa004600.54004237
112Gastric acid secretion_Homo sapiens_hsa049710.53787817
113Serotonergic synapse_Homo sapiens_hsa047260.53780118
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53763214
115Arginine and proline metabolism_Homo sapiens_hsa003300.52141185
116Sphingolipid metabolism_Homo sapiens_hsa006000.51810875
117Inositol phosphate metabolism_Homo sapiens_hsa005620.51647398
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51185010
1192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50954364
120Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50661476
121Non-small cell lung cancer_Homo sapiens_hsa052230.49748813
122Pancreatic secretion_Homo sapiens_hsa049720.49680433
123Arachidonic acid metabolism_Homo sapiens_hsa005900.49023105
124Melanogenesis_Homo sapiens_hsa049160.48863336
125cAMP signaling pathway_Homo sapiens_hsa040240.48631980
126Oxytocin signaling pathway_Homo sapiens_hsa049210.48609071
127Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47984996
128Galactose metabolism_Homo sapiens_hsa000520.45707709
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43897443
130Thyroid cancer_Homo sapiens_hsa052160.43427873
131Prolactin signaling pathway_Homo sapiens_hsa049170.43003238
132Phenylalanine metabolism_Homo sapiens_hsa003600.42399550
133Ovarian steroidogenesis_Homo sapiens_hsa049130.39337992
134SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38662533
135Insulin signaling pathway_Homo sapiens_hsa049100.38429588

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