ZIM3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of retinoic acid receptor signaling pathway (GO:0048387)8.28886449
2regulation of retinoic acid receptor signaling pathway (GO:0048385)7.07319208
3behavioral response to nicotine (GO:0035095)5.13422623
4fucose catabolic process (GO:0019317)4.73034478
5L-fucose metabolic process (GO:0042354)4.73034478
6L-fucose catabolic process (GO:0042355)4.73034478
7DNA deamination (GO:0045006)4.61026894
8protein-cofactor linkage (GO:0018065)4.32774818
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.98189707
10detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.87277228
11male meiosis I (GO:0007141)3.76547675
12tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.69712193
13RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.69712193
14water-soluble vitamin biosynthetic process (GO:0042364)3.52847568
15piRNA metabolic process (GO:0034587)3.50983691
16mitochondrial respiratory chain complex I assembly (GO:0032981)3.40553943
17NADH dehydrogenase complex assembly (GO:0010257)3.40553943
18mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.40553943
19preassembly of GPI anchor in ER membrane (GO:0016254)3.34129185
20maturation of 5.8S rRNA (GO:0000460)3.30926935
21exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.29722697
22nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.29014891
23protein complex biogenesis (GO:0070271)3.26078446
24respiratory chain complex IV assembly (GO:0008535)3.21906485
25pseudouridine synthesis (GO:0001522)3.18004420
26cellular ketone body metabolic process (GO:0046950)3.16126145
27platelet dense granule organization (GO:0060155)3.15196813
28epithelial cilium movement (GO:0003351)3.13501133
29neuron fate determination (GO:0048664)3.10618527
30mitochondrial respiratory chain complex assembly (GO:0033108)3.09614744
31negative regulation of telomere maintenance (GO:0032205)3.07579178
32nephron epithelium morphogenesis (GO:0072088)3.04260295
33nephron tubule morphogenesis (GO:0072078)3.04260295
34meiosis I (GO:0007127)3.03382724
35negative regulation of mast cell activation (GO:0033004)3.02451112
36rRNA modification (GO:0000154)3.00977513
37protein K6-linked ubiquitination (GO:0085020)3.00288654
38ketone body metabolic process (GO:1902224)3.00261147
39chaperone-mediated protein transport (GO:0072321)2.98039925
40indolalkylamine metabolic process (GO:0006586)2.95561905
41multicellular organism reproduction (GO:0032504)2.95493152
42ATP synthesis coupled proton transport (GO:0015986)2.94776456
43energy coupled proton transport, down electrochemical gradient (GO:0015985)2.94776456
44male meiosis (GO:0007140)2.93717739
45kidney morphogenesis (GO:0060993)2.90809081
46protein K11-linked deubiquitination (GO:0035871)2.90405480
47tRNA processing (GO:0008033)2.89277705
48DNA methylation involved in gamete generation (GO:0043046)2.86767835
49termination of RNA polymerase III transcription (GO:0006386)2.86059542
50transcription elongation from RNA polymerase III promoter (GO:0006385)2.86059542
51establishment of protein localization to mitochondrial membrane (GO:0090151)2.83943444
52ubiquinone biosynthetic process (GO:0006744)2.83396165
53regulation of nuclear cell cycle DNA replication (GO:0033262)2.83117796
54auditory receptor cell stereocilium organization (GO:0060088)2.82193172
55reciprocal DNA recombination (GO:0035825)2.77594196
56reciprocal meiotic recombination (GO:0007131)2.77594196
57indole-containing compound catabolic process (GO:0042436)2.74509469
58indolalkylamine catabolic process (GO:0046218)2.74509469
59tryptophan catabolic process (GO:0006569)2.74509469
60regulation of cilium movement (GO:0003352)2.73937942
61tRNA modification (GO:0006400)2.73167927
62positive regulation of protein homooligomerization (GO:0032464)2.70940670
63mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.70591097
64axoneme assembly (GO:0035082)2.70236737
65DNA double-strand break processing (GO:0000729)2.69836472
66rRNA catabolic process (GO:0016075)2.67800269
67mannosylation (GO:0097502)2.67714041
68peptidyl-histidine modification (GO:0018202)2.67578000
69cilium morphogenesis (GO:0060271)2.65148454
70ubiquinone metabolic process (GO:0006743)2.64159934
71rRNA methylation (GO:0031167)2.63619719
72cytochrome complex assembly (GO:0017004)2.63604845
73kynurenine metabolic process (GO:0070189)2.63531386
74recombinational repair (GO:0000725)2.62763296
75photoreceptor cell development (GO:0042461)2.62688989
76nonmotile primary cilium assembly (GO:0035058)2.62457254
77protein polyglutamylation (GO:0018095)2.60792283
78fucosylation (GO:0036065)2.60281206
79double-strand break repair via homologous recombination (GO:0000724)2.58661149
80response to pheromone (GO:0019236)2.57729818
81negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.55005884
82cilium movement (GO:0003341)2.54985669
83positive regulation of prostaglandin secretion (GO:0032308)2.54712873
84retinal cone cell development (GO:0046549)2.52844837
85mitochondrial RNA metabolic process (GO:0000959)2.52323630
86replication fork processing (GO:0031297)2.49585657
87intracellular protein transmembrane import (GO:0044743)2.48863869
88negative regulation of DNA-dependent DNA replication (GO:2000104)2.45142090
89regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.43845140
90GPI anchor metabolic process (GO:0006505)2.43067572
91detection of light stimulus involved in sensory perception (GO:0050962)2.43006867
92detection of light stimulus involved in visual perception (GO:0050908)2.43006867
93protein neddylation (GO:0045116)2.41670222
94negative regulation of transcription regulatory region DNA binding (GO:2000678)2.41420746
95tryptophan metabolic process (GO:0006568)2.41189297
96cornea development in camera-type eye (GO:0061303)2.40821151
97L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.39276491
98negative regulation of reactive oxygen species metabolic process (GO:2000378)2.38422718
99regulation of rhodopsin mediated signaling pathway (GO:0022400)2.38282706
100detection of mechanical stimulus involved in sensory perception (GO:0050974)2.37537924

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.50191295
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.41517609
3VDR_22108803_ChIP-Seq_LS180_Human3.31940208
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.02795844
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.87651737
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.84298468
7EZH2_22144423_ChIP-Seq_EOC_Human2.78473435
8NOTCH1_21737748_ChIP-Seq_TLL_Human2.64640788
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.55920435
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.46355562
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.14458645
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.12330701
13GBX2_23144817_ChIP-Seq_PC3_Human2.03605508
14EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.98137146
15ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95095343
16CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92530945
17EWS_26573619_Chip-Seq_HEK293_Human1.91713103
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.90160980
19IGF1R_20145208_ChIP-Seq_DFB_Human1.89599599
20TP53_22573176_ChIP-Seq_HFKS_Human1.89579642
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.89230207
22IRF1_19129219_ChIP-ChIP_H3396_Human1.89066820
23ETS1_20019798_ChIP-Seq_JURKAT_Human1.88490355
24VDR_23849224_ChIP-Seq_CD4+_Human1.85620828
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83972133
26MYC_18940864_ChIP-ChIP_HL60_Human1.80735604
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78673961
28P300_19829295_ChIP-Seq_ESCs_Human1.72819495
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67614270
30MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.64091936
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.61991127
32FUS_26573619_Chip-Seq_HEK293_Human1.59684449
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58234598
34ER_23166858_ChIP-Seq_MCF-7_Human1.51939923
35ELK1_19687146_ChIP-ChIP_HELA_Human1.51618247
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.45356994
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40398870
38NANOG_19829295_ChIP-Seq_ESCs_Human1.33287368
39SOX2_19829295_ChIP-Seq_ESCs_Human1.33287368
40BCAT_22108803_ChIP-Seq_LS180_Human1.32654184
41TAF15_26573619_Chip-Seq_HEK293_Human1.32060936
42HOXB7_26014856_ChIP-Seq_BT474_Human1.31724155
43GATA3_21878914_ChIP-Seq_MCF-7_Human1.31435777
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31254203
45FOXA1_25329375_ChIP-Seq_VCAP_Human1.30606579
46FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30606579
47FOXP3_21729870_ChIP-Seq_TREG_Human1.28808969
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.27323901
49GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26594637
50ETV2_25802403_ChIP-Seq_MESCs_Mouse1.26249577
51NCOR_22424771_ChIP-Seq_293T_Human1.25740083
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25636900
53CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.22138193
54AR_20517297_ChIP-Seq_VCAP_Human1.22132355
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18853740
56CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.18534011
57TCF4_22108803_ChIP-Seq_LS180_Human1.16336789
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14889262
59* STAT3_23295773_ChIP-Seq_U87_Human1.12504008
60REST_21632747_ChIP-Seq_MESCs_Mouse1.12114380
61CBP_20019798_ChIP-Seq_JUKART_Human1.12093535
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12093535
63AR_25329375_ChIP-Seq_VCAP_Human1.11250961
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.10471658
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.09255256
66PHF8_20622853_ChIP-Seq_HELA_Human1.09166848
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08383076
68MYC_19829295_ChIP-Seq_ESCs_Human1.08132945
69ETV1_20927104_ChIP-Seq_GIST48_Human1.07294453
70SALL1_21062744_ChIP-ChIP_HESCs_Human1.06817986
71KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06478959
72* NANOG_20526341_ChIP-Seq_ESCs_Human1.06272037
73RBPJ_21746931_ChIP-Seq_IB4_Human1.05694396
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.05651281
75NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05143580
76TCF4_23295773_ChIP-Seq_U87_Human1.04968631
77AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03918242
78SMAD4_21799915_ChIP-Seq_A2780_Human1.03758826
79PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03633920
80GATA6_21074721_ChIP-Seq_CACO-2_Human1.02859077
81SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02627841
82FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01145693
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00879344
84SMAD4_21741376_ChIP-Seq_EPCs_Human1.00282324
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99201005
86ERA_21632823_ChIP-Seq_H3396_Human0.98911728
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98664420
88RUNX2_22187159_ChIP-Seq_PCA_Human0.97970793
89POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97924004
90FOXH1_21741376_ChIP-Seq_EPCs_Human0.97808943
91RNF2_27304074_Chip-Seq_NSC_Mouse0.97413621
92EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97008191
93GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.96122234
94GATA3_26560356_Chip-Seq_TH2_Human0.95541668
95NFYB_21822215_ChIP-Seq_K562_Human0.94406979
96PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94177249
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94152656
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94152656
99CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93732768
100P53_21459846_ChIP-Seq_SAOS-2_Human0.93610484

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity3.47895740
2MP0008877_abnormal_DNA_methylation3.00527330
3MP0006292_abnormal_olfactory_placode2.99374626
4MP0002102_abnormal_ear_morphology2.83188469
5MP0002837_dystrophic_cardiac_calcinosis2.65557556
6MP0003646_muscle_fatigue2.50663185
7MP0000372_irregular_coat_pigmentation2.36799980
8MP0005551_abnormal_eye_electrophysiolog2.25229974
9MP0003195_calcinosis2.21094305
10MP0004147_increased_porphyrin_level2.17208429
11MP0006072_abnormal_retinal_apoptosis2.07314533
12MP0002638_abnormal_pupillary_reflex2.06506676
13MP0002938_white_spotting1.97477967
14MP0003136_yellow_coat_color1.95332236
15MP0001968_abnormal_touch/_nociception1.92749387
16MP0008872_abnormal_physiological_respon1.91479386
17MP0002163_abnormal_gland_morphology1.90518961
18MP0005084_abnormal_gallbladder_morpholo1.84099309
19MP0005645_abnormal_hypothalamus_physiol1.82333704
20MP0003787_abnormal_imprinting1.82066707
21MP0005646_abnormal_pituitary_gland1.77414424
22MP0008875_abnormal_xenobiotic_pharmacok1.76269547
23MP0005423_abnormal_somatic_nervous1.75843215
24MP0002138_abnormal_hepatobiliary_system1.71329882
25MP0004885_abnormal_endolymph1.69720804
26MP0005075_abnormal_melanosome_morpholog1.68263135
27MP0005253_abnormal_eye_physiology1.66164907
28MP0005379_endocrine/exocrine_gland_phen1.65458836
29MP0003718_maternal_effect1.64674039
30MP0002876_abnormal_thyroid_physiology1.60163776
31MP0004142_abnormal_muscle_tone1.57780121
32MP0003011_delayed_dark_adaptation1.55209774
33MP0006276_abnormal_autonomic_nervous1.51472961
34MP0001984_abnormal_olfaction1.48257022
35MP0009745_abnormal_behavioral_response1.46843886
36MP0002095_abnormal_skin_pigmentation1.45488861
37MP0004043_abnormal_pH_regulation1.45049987
38MP0008058_abnormal_DNA_repair1.42518593
39MP0000631_abnormal_neuroendocrine_gland1.41788978
40MP0000427_abnormal_hair_cycle1.40281547
41MP0002736_abnormal_nociception_after1.39941218
42MP0002653_abnormal_ependyma_morphology1.38673416
43MP0009046_muscle_twitch1.38558331
44MP0001501_abnormal_sleep_pattern1.35592758
45MP0005389_reproductive_system_phenotype1.35042310
46MP0002160_abnormal_reproductive_system1.33759999
47MP0002234_abnormal_pharynx_morphology1.32650948
48MP0003122_maternal_imprinting1.31895534
49MP0003121_genomic_imprinting1.28552049
50MP0000569_abnormal_digit_pigmentation1.25966093
51MP0001486_abnormal_startle_reflex1.23958099
52MP0004133_heterotaxia1.23241425
53MP0002272_abnormal_nervous_system1.22971449
54MP0003878_abnormal_ear_physiology1.20365135
55MP0005377_hearing/vestibular/ear_phenot1.20365135
56MP0008789_abnormal_olfactory_epithelium1.17422575
57MP0002928_abnormal_bile_duct1.15201319
58MP0002277_abnormal_respiratory_mucosa1.14667314
59MP0005174_abnormal_tail_pigmentation1.10933209
60MP0001919_abnormal_reproductive_system1.10658729
61MP0001529_abnormal_vocalization1.10098476
62MP0001293_anophthalmia1.09308416
63MP0000015_abnormal_ear_pigmentation1.08550040
64MP0003880_abnormal_central_pattern1.06341173
65MP0002572_abnormal_emotion/affect_behav1.03456773
66MP0003806_abnormal_nucleotide_metabolis1.01469498
67MP0000026_abnormal_inner_ear0.99306614
68MP0005394_taste/olfaction_phenotype0.98277726
69MP0005499_abnormal_olfactory_system0.98277726
70MP0001905_abnormal_dopamine_level0.96705807
71MP0001764_abnormal_homeostasis0.96468277
72MP0008995_early_reproductive_senescence0.96008041
73MP0001485_abnormal_pinna_reflex0.94378938
74MP0001324_abnormal_eye_pigmentation0.94306840
75MP0005195_abnormal_posterior_eye0.94017357
76MP0002210_abnormal_sex_determination0.93954835
77MP0006036_abnormal_mitochondrial_physio0.93915449
78MP0002735_abnormal_chemical_nociception0.93691299
79MP0005167_abnormal_blood-brain_barrier0.93131767
80MP0001929_abnormal_gametogenesis0.92007119
81MP0002557_abnormal_social/conspecific_i0.91777136
82MP0003186_abnormal_redox_activity0.91718031
83MP0004145_abnormal_muscle_electrophysio0.90254529
84MP0003283_abnormal_digestive_organ0.89714337
85MP0002733_abnormal_thermal_nociception0.87091161
86MP0005410_abnormal_fertilization0.84803928
87MP0003786_premature_aging0.84411724
88MP0002064_seizures0.82520387
89MP0004742_abnormal_vestibular_system0.82165597
90MP0005220_abnormal_exocrine_pancreas0.81940094
91MP0001970_abnormal_pain_threshold0.80510921
92MP0005386_behavior/neurological_phenoty0.80341111
93MP0004924_abnormal_behavior0.80341111
94MP0003698_abnormal_male_reproductive0.79339086
95MP0000049_abnormal_middle_ear0.78494059
96MP0002067_abnormal_sensory_capabilities0.77116076
97MP0001502_abnormal_circadian_rhythm0.76990962
98MP0002751_abnormal_autonomic_nervous0.76144306
99MP0005408_hypopigmentation0.75608177
100MP0000230_abnormal_systemic_arterial0.75272510

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.69988663
2Pancreatic fibrosis (HP:0100732)4.35984716
3Congenital stationary night blindness (HP:0007642)4.17697532
4Abnormality of midbrain morphology (HP:0002418)3.77487714
5Molar tooth sign on MRI (HP:0002419)3.77487714
6True hermaphroditism (HP:0010459)3.69491341
7Polydipsia (HP:0001959)3.31940960
8Abnormal drinking behavior (HP:0030082)3.31940960
9Nephronophthisis (HP:0000090)3.31067609
10Abnormality of alanine metabolism (HP:0010916)3.24203250
11Hyperalaninemia (HP:0003348)3.24203250
12Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.24203250
13Abnormality of the renal cortex (HP:0011035)3.20154873
14Type II lissencephaly (HP:0007260)3.14169399
15Tubular atrophy (HP:0000092)3.10428915
16Abnormality of the renal medulla (HP:0100957)3.05294351
17Attenuation of retinal blood vessels (HP:0007843)2.84580728
18Cystic liver disease (HP:0006706)2.80353025
19Lipid accumulation in hepatocytes (HP:0006561)2.79659196
20Abolished electroretinogram (ERG) (HP:0000550)2.75067375
21Abnormal biliary tract physiology (HP:0012439)2.71720730
22Bile duct proliferation (HP:0001408)2.71720730
23Medial flaring of the eyebrow (HP:0010747)2.68710003
24Pendular nystagmus (HP:0012043)2.67945131
25Acute necrotizing encephalopathy (HP:0006965)2.63026497
26Mitochondrial inheritance (HP:0001427)2.60140070
27Abnormal rod and cone electroretinograms (HP:0008323)2.59666483
28Increased hepatocellular lipid droplets (HP:0006565)2.57370620
29Increased CSF lactate (HP:0002490)2.57015370
30Polyuria (HP:0000103)2.54608226
31Aplasia/hypoplasia of the uterus (HP:0008684)2.45339229
32Chronic hepatic failure (HP:0100626)2.45113878
33Congenital, generalized hypertrichosis (HP:0004540)2.45077940
34Acute encephalopathy (HP:0006846)2.35849159
35Concave nail (HP:0001598)2.25879970
36Abnormal number of erythroid precursors (HP:0012131)2.24091209
37Sclerocornea (HP:0000647)2.23441909
38Congenital hepatic fibrosis (HP:0002612)2.23113595
39Decreased electroretinogram (ERG) amplitude (HP:0000654)2.22289383
40Aplasia/Hypoplasia of the spleen (HP:0010451)2.18574854
41Inability to walk (HP:0002540)2.18419716
42Progressive macrocephaly (HP:0004481)2.18228256
43Hypoplasia of the uterus (HP:0000013)2.17501561
44Abnormal mitochondria in muscle tissue (HP:0008316)2.17444446
45Aplasia/Hypoplasia of the tongue (HP:0010295)2.15996557
46Increased corneal curvature (HP:0100692)2.15522701
47Keratoconus (HP:0000563)2.15522701
48Methylmalonic acidemia (HP:0002912)2.13027205
49Progressive inability to walk (HP:0002505)2.11088010
50Optic nerve hypoplasia (HP:0000609)2.10755030
51Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.10159610
52Birth length less than 3rd percentile (HP:0003561)2.09148147
53Optic disc pallor (HP:0000543)2.06006461
54Abnormal respiratory motile cilium morphology (HP:0005938)2.05548453
55Abnormal respiratory epithelium morphology (HP:0012253)2.05548453
56Aplasia/Hypoplasia of the tibia (HP:0005772)2.05062064
57Lissencephaly (HP:0001339)2.04883743
58Methylmalonic aciduria (HP:0012120)2.04069981
59Male pseudohermaphroditism (HP:0000037)2.03980124
60Abnormal urine output (HP:0012590)2.03927476
61Glycosuria (HP:0003076)2.02820257
62Abnormality of urine glucose concentration (HP:0011016)2.02820257
63Aplasia/Hypoplasia of the fovea (HP:0008060)2.02318834
64Hypoplasia of the fovea (HP:0007750)2.02318834
65Hyperventilation (HP:0002883)2.02302243
66Decreased central vision (HP:0007663)2.02051855
67Absent rod-and cone-mediated responses on ERG (HP:0007688)2.01895779
68Increased serum lactate (HP:0002151)2.01135922
69Gait imbalance (HP:0002141)1.99732273
70Chorioretinal atrophy (HP:0000533)1.98878941
713-Methylglutaconic aciduria (HP:0003535)1.98303366
72Anencephaly (HP:0002323)1.98159641
73Nephrogenic diabetes insipidus (HP:0009806)1.97620508
74Congenital primary aphakia (HP:0007707)1.97432609
75Asplenia (HP:0001746)1.96307499
76Abnormality of cells of the erythroid lineage (HP:0012130)1.94673588
77Abnormality of the labia minora (HP:0012880)1.94098572
78Constricted visual fields (HP:0001133)1.93783970
79Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.92778159
80Renal Fanconi syndrome (HP:0001994)1.90030656
81Renal cortical cysts (HP:0000803)1.88697703
82Patellar aplasia (HP:0006443)1.88059967
83Aplasia/Hypoplasia of the patella (HP:0006498)1.87729720
84Retinal dysplasia (HP:0007973)1.87028249
85Hepatocellular necrosis (HP:0001404)1.86165114
86Abnormality of the renal collecting system (HP:0004742)1.85196685
87Duplicated collecting system (HP:0000081)1.85054961
88Hepatic necrosis (HP:0002605)1.84537325
89Cerebellar dysplasia (HP:0007033)1.83488468
90Abnormality of the pons (HP:0007361)1.83329340
91Postaxial foot polydactyly (HP:0001830)1.82049616
92Short tibia (HP:0005736)1.82045536
93Large for gestational age (HP:0001520)1.81707135
94Abnormality of the fovea (HP:0000493)1.78625780
95Supernumerary spleens (HP:0009799)1.76429016
96Abnormality of renal excretion (HP:0011036)1.76128783
97Polyphagia (HP:0002591)1.75129004
98Hypomagnesemia (HP:0002917)1.74781745
99Tubulointerstitial fibrosis (HP:0005576)1.73861622
100Hypoplasia of the pons (HP:0012110)1.73831017

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.97147701
2ADRBK23.54224631
3TAOK33.22509860
4TLK12.78075591
5MAP4K22.71058415
6WNK42.59607569
7ZAK2.56384047
8WNK32.47715463
9GRK12.43094675
10BMPR1B2.37677440
11PINK12.30079446
12NUAK12.27464464
13INSRR2.01053787
14ACVR1B1.86754028
15TXK1.79963256
16STK391.60768667
17TRIM281.55663626
18OXSR11.49042188
19CASK1.45715149
20CDK191.43810795
21DYRK21.39464892
22STK161.38169148
23DAPK21.36029884
24MST41.35510734
25MAPK131.33558902
26BCKDK1.29198288
27TIE11.25194268
28BUB11.25182263
29VRK21.23492539
30MAP3K41.22750684
31VRK11.17345400
32ADRBK11.11281068
33PLK31.09087824
34PASK1.04918817
35TSSK61.01235061
36TGFBR10.95897260
37MKNK20.90154353
38MAP2K70.88953195
39PLK20.88306655
40SRPK10.84874526
41PRKCG0.82228784
42PHKG20.81839627
43PHKG10.81839627
44EIF2AK30.81135542
45PLK40.80274966
46BRSK20.80197889
47PRKCE0.80131322
48NTRK20.77686394
49PAK30.76112352
50MAP2K60.75712819
51PLK10.74247424
52STK110.73853797
53BCR0.73268195
54IKBKB0.71848919
55EPHA30.71047979
56NME10.69552896
57KIT0.68972760
58CAMKK20.68780555
59PRKCQ0.68385516
60CSNK1G10.67821389
61MUSK0.65584572
62PIK3CA0.65111087
63NEK20.64099902
64ATR0.62351014
65CSNK1G30.62085920
66CSNK1G20.58831389
67MAPKAPK50.58681258
68RPS6KA50.58038640
69PRKCI0.57509813
70CSNK1A10.54517461
71MARK30.54087220
72STK30.53983621
73PDK20.53827225
74MAPKAPK30.53800263
75WEE10.52929599
76PRKACA0.50037977
77CAMK2A0.49003116
78CSNK1A1L0.47756803
79PTK2B0.47381042
80IRAK10.47006974
81MKNK10.46401335
82TEC0.46150846
83NTRK30.44074135
84MAPK150.42733778
85MARK10.41635438
86OBSCN0.40400894
87PRKG10.39881800
88CHEK20.39880470
89CSNK2A10.39270507
90MAP2K20.39157390
91PRKCA0.38756015
92PRKCZ0.37996084
93PKN10.37882365
94EPHA40.36809809
95NEK10.35282176
96TNIK0.34345397
97CDK30.30531452
98AURKB0.30019818
99EIF2AK20.29857566
100FGFR20.29790669

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030222.65243115
2RNA polymerase_Homo sapiens_hsa030202.63111519
3Oxidative phosphorylation_Homo sapiens_hsa001902.59423354
4Phototransduction_Homo sapiens_hsa047442.48093632
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.45404404
6Homologous recombination_Homo sapiens_hsa034402.40736897
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.34038586
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.26150975
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.24145063
10Linoleic acid metabolism_Homo sapiens_hsa005912.20877649
11Parkinsons disease_Homo sapiens_hsa050122.10941587
12Protein export_Homo sapiens_hsa030602.07730995
13Nitrogen metabolism_Homo sapiens_hsa009102.05017979
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.00043329
15Butanoate metabolism_Homo sapiens_hsa006501.97642345
16Ribosome_Homo sapiens_hsa030101.90728568
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.86862747
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.86837343
19Proteasome_Homo sapiens_hsa030501.77053011
20Fanconi anemia pathway_Homo sapiens_hsa034601.75971305
21RNA degradation_Homo sapiens_hsa030181.74657798
22Selenocompound metabolism_Homo sapiens_hsa004501.69754813
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.61060382
24One carbon pool by folate_Homo sapiens_hsa006701.59040401
25Caffeine metabolism_Homo sapiens_hsa002321.58472284
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.58252916
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.56752889
28Huntingtons disease_Homo sapiens_hsa050161.48959178
29Regulation of autophagy_Homo sapiens_hsa041401.48640731
30Ether lipid metabolism_Homo sapiens_hsa005651.47488990
31Sulfur relay system_Homo sapiens_hsa041221.46933207
32Nicotine addiction_Homo sapiens_hsa050331.39714855
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.37145025
34Tryptophan metabolism_Homo sapiens_hsa003801.30726077
35Olfactory transduction_Homo sapiens_hsa047401.25349397
36Cardiac muscle contraction_Homo sapiens_hsa042601.23049298
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.22399106
38Propanoate metabolism_Homo sapiens_hsa006401.17425619
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16454374
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15465334
41Alzheimers disease_Homo sapiens_hsa050101.15461134
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.14449228
43Taste transduction_Homo sapiens_hsa047421.12329915
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.10072913
45Pyrimidine metabolism_Homo sapiens_hsa002401.06269552
46Peroxisome_Homo sapiens_hsa041461.03156070
47Arachidonic acid metabolism_Homo sapiens_hsa005901.00217135
48Chemical carcinogenesis_Homo sapiens_hsa052040.98547828
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.97115916
50Morphine addiction_Homo sapiens_hsa050320.95840800
51Purine metabolism_Homo sapiens_hsa002300.95772517
52RNA transport_Homo sapiens_hsa030130.93480358
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93356408
54Asthma_Homo sapiens_hsa053100.88588683
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87846787
56Sulfur metabolism_Homo sapiens_hsa009200.85603256
57Primary immunodeficiency_Homo sapiens_hsa053400.85283189
58Collecting duct acid secretion_Homo sapiens_hsa049660.84056093
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81536221
60Insulin secretion_Homo sapiens_hsa049110.79820483
61Steroid biosynthesis_Homo sapiens_hsa001000.76321260
62Nucleotide excision repair_Homo sapiens_hsa034200.74920230
63Mismatch repair_Homo sapiens_hsa034300.73486976
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.72576991
65Serotonergic synapse_Homo sapiens_hsa047260.70156050
66ABC transporters_Homo sapiens_hsa020100.69184831
67Metabolic pathways_Homo sapiens_hsa011000.67908345
68Retinol metabolism_Homo sapiens_hsa008300.67220428
69GABAergic synapse_Homo sapiens_hsa047270.65273746
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64547813
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64292118
72Ovarian steroidogenesis_Homo sapiens_hsa049130.62074118
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.60489803
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59828189
75Type I diabetes mellitus_Homo sapiens_hsa049400.59001818
76Fat digestion and absorption_Homo sapiens_hsa049750.58813613
77Non-homologous end-joining_Homo sapiens_hsa034500.58659778
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55872556
79Circadian entrainment_Homo sapiens_hsa047130.55342211
80Spliceosome_Homo sapiens_hsa030400.54079910
81Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54020034
82Folate biosynthesis_Homo sapiens_hsa007900.51668375
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47472988
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46592489
85Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.45675830
86Mineral absorption_Homo sapiens_hsa049780.41602913
87beta-Alanine metabolism_Homo sapiens_hsa004100.40846761
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40530403
89Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40426900
90Glycerolipid metabolism_Homo sapiens_hsa005610.39180635
91Allograft rejection_Homo sapiens_hsa053300.38083505
92Base excision repair_Homo sapiens_hsa034100.37268810
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37210114
94DNA replication_Homo sapiens_hsa030300.37013664
95p53 signaling pathway_Homo sapiens_hsa041150.36935149
96Salivary secretion_Homo sapiens_hsa049700.35316366
97Autoimmune thyroid disease_Homo sapiens_hsa053200.35177966
98Rheumatoid arthritis_Homo sapiens_hsa053230.33084328
99Calcium signaling pathway_Homo sapiens_hsa040200.32834946
100Glutathione metabolism_Homo sapiens_hsa004800.32678757

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »