ZHX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1germinal center formation (GO:0002467)4.36758265
2regulation of interleukin-12 biosynthetic process (GO:0045075)4.09079682
3growth hormone receptor signaling pathway (GO:0060396)3.62294571
4type I interferon signaling pathway (GO:0060337)3.49208249
5cellular response to type I interferon (GO:0071357)3.49208249
6positive regulation of gamma-delta T cell activation (GO:0046645)3.48641726
7positive regulation of fatty acid beta-oxidation (GO:0032000)3.48187064
8response to type I interferon (GO:0034340)3.46869770
9regulation of T-helper 1 cell differentiation (GO:0045625)3.40990590
10regulation of T-helper 2 cell differentiation (GO:0045628)3.35291580
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.32196749
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.32196749
13valine metabolic process (GO:0006573)3.31941152
14antigen processing and presentation of endogenous antigen (GO:0019883)3.31538796
15regulation of cholesterol homeostasis (GO:2000188)3.28785194
16regulation of gamma-delta T cell differentiation (GO:0045586)3.24658558
17negative regulation of cytokine production involved in immune response (GO:0002719)3.21919314
18B cell receptor signaling pathway (GO:0050853)3.19494518
19regulation of gamma-delta T cell activation (GO:0046643)3.17664101
20positive regulation of histone deacetylation (GO:0031065)3.13325084
21cellular response to growth hormone stimulus (GO:0071378)3.10507721
22macrophage activation involved in immune response (GO:0002281)3.09869440
23positive thymic T cell selection (GO:0045059)3.05109924
24myeloid dendritic cell differentiation (GO:0043011)3.02832686
25JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.00820855
26positive regulation of p38MAPK cascade (GO:1900745)3.00229478
27CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.97912579
28T-helper cell differentiation (GO:0042093)2.97912579
29regulation of fatty acid beta-oxidation (GO:0031998)2.96237962
30regulation of interferon-beta biosynthetic process (GO:0045357)2.91917335
31positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.90870356
32negative regulation of interleukin-12 production (GO:0032695)2.90259340
33regulation of interferon-alpha production (GO:0032647)2.89986884
34defense response to protozoan (GO:0042832)2.87113021
35antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.87086803
36regulation of type I interferon-mediated signaling pathway (GO:0060338)2.86189884
37negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.85208905
38negative regulation of T-helper cell differentiation (GO:0045623)2.85208905
39response to peptidoglycan (GO:0032494)2.84510759
40histone H3-K36 demethylation (GO:0070544)2.84309248
41negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.83265222
42positive regulation of fatty acid oxidation (GO:0046321)2.80975935
43lipopolysaccharide-mediated signaling pathway (GO:0031663)2.80567314
44CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.80260684
45regulation of p38MAPK cascade (GO:1900744)2.79539032
46positive regulation of type 2 immune response (GO:0002830)2.75820811
472-oxoglutarate metabolic process (GO:0006103)2.69561446
48negative regulation of fatty acid transport (GO:2000192)2.69436441
49negative regulation of production of molecular mediator of immune response (GO:0002701)2.69121737
50low-density lipoprotein particle clearance (GO:0034383)2.68551637
51response to protozoan (GO:0001562)2.67244821
52positive regulation of interferon-alpha production (GO:0032727)2.66925200
53positive regulation of glycogen biosynthetic process (GO:0045725)2.65649302
54positive regulation of extracellular matrix organization (GO:1903055)2.65199568
55positive regulation of natural killer cell differentiation (GO:0032825)2.65057204
56positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.63691706
57negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.61326915
58positive regulation of lipid storage (GO:0010884)2.61224277
59interferon-gamma-mediated signaling pathway (GO:0060333)2.61118948
60cellular response to interleukin-15 (GO:0071350)2.61029780
61B cell proliferation (GO:0042100)2.60419435
62modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.60076203
63positive regulation by organism of defense response of other organism involved in symbiotic interact2.60076203
64modulation by symbiont of host immune response (GO:0052553)2.60076203
65positive regulation by symbiont of host defense response (GO:0052509)2.60076203
66modulation by symbiont of host defense response (GO:0052031)2.60076203
67modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.60076203
68myeloid dendritic cell activation (GO:0001773)2.59610086
69positive regulation of B cell proliferation (GO:0030890)2.59432551
70alpha-linolenic acid metabolic process (GO:0036109)2.59118089
71positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.57699909
72regulation of B cell receptor signaling pathway (GO:0050855)2.56922185
73regulation of dendritic cell antigen processing and presentation (GO:0002604)2.56246918
74regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.56081130
75positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.54677052
76sarcomere organization (GO:0045214)2.54549918
77thymic T cell selection (GO:0045061)2.53490140
78regulation of fatty acid oxidation (GO:0046320)2.52212190
79carnitine shuttle (GO:0006853)2.52088616
80regulation of cytokine secretion involved in immune response (GO:0002739)2.51430416
81fatty acid transmembrane transport (GO:1902001)2.50750127
82B cell homeostasis (GO:0001782)2.50348448
83immunoglobulin mediated immune response (GO:0016064)2.49851735
84regulation of vitamin D biosynthetic process (GO:0060556)2.49682887
85production of molecular mediator involved in inflammatory response (GO:0002532)2.48756959
86negative thymic T cell selection (GO:0045060)2.48036743
87alpha-beta T cell differentiation involved in immune response (GO:0002293)2.47763288
88alpha-beta T cell activation involved in immune response (GO:0002287)2.47763288
89T cell differentiation involved in immune response (GO:0002292)2.47763288
90response to laminar fluid shear stress (GO:0034616)2.47131288
91positive regulation of lipid catabolic process (GO:0050996)2.46103509
92tolerance induction (GO:0002507)2.45713753
93positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.45342520
94regulation of type 2 immune response (GO:0002828)2.45160619
95creatine metabolic process (GO:0006600)2.44294779
96detection of other organism (GO:0098543)2.42296532
97phospholipid homeostasis (GO:0055091)2.42034440
98regulation of cholesterol storage (GO:0010885)2.41820788
99positive T cell selection (GO:0043368)2.41516929
100modulation by symbiont of host cellular process (GO:0044068)2.40694950
101negative regulation of myeloid cell apoptotic process (GO:0033033)2.39930612
102negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.39920047
103positive regulation of humoral immune response (GO:0002922)2.39808654
104negative regulation of T cell mediated immunity (GO:0002710)2.39566235
105tricarboxylic acid metabolic process (GO:0072350)2.39292048
106detection of molecule of bacterial origin (GO:0032490)2.38565968
107regulation of T-helper cell differentiation (GO:0045622)2.37837539
108positive regulation of glycogen metabolic process (GO:0070875)2.37625522
109negative T cell selection (GO:0043383)2.37573080
110negative regulation of lymphocyte mediated immunity (GO:0002707)2.37525986
111negative regulation of lipid transport (GO:0032369)2.37361441
112regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.35918923
113neutrophil activation involved in immune response (GO:0002283)2.35390610
114positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.34033294
115lysine metabolic process (GO:0006553)2.33012395
116lysine catabolic process (GO:0006554)2.33012395
117regulation of extracellular matrix organization (GO:1903053)2.32800268
118T-helper 1 type immune response (GO:0042088)2.32740984
119regulation of necroptotic process (GO:0060544)2.32598157
120cellular response to virus (GO:0098586)2.32509131
121detection of bacterium (GO:0016045)2.32307475
122NIK/NF-kappaB signaling (GO:0038061)2.31269264
123granulocyte activation (GO:0036230)2.31002885
124fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.30657239
125T cell selection (GO:0045058)2.30330673
126skeletal muscle adaptation (GO:0043501)2.29012758
127regulation of sequestering of triglyceride (GO:0010889)2.28156959
128positive regulation of heat generation (GO:0031652)2.25316218
129negative regulation of lipid storage (GO:0010888)2.25295936
130positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.24450804
131striated muscle atrophy (GO:0014891)2.24247089
132regulation of membrane protein ectodomain proteolysis (GO:0051043)2.22485374
133embryonic retina morphogenesis in camera-type eye (GO:0060059)2.20036053
134regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.19138136
135regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.18553411
136oxaloacetate metabolic process (GO:0006107)2.18355800
137myofibril assembly (GO:0030239)2.18185375
138insulin-like growth factor receptor signaling pathway (GO:0048009)2.16073240
139leukocyte aggregation (GO:0070486)2.14700178
140cellular response to zinc ion (GO:0071294)2.14550181
141cardiac myofibril assembly (GO:0055003)2.13227295
142regulation of T cell tolerance induction (GO:0002664)2.12151515
143cellular response to nicotine (GO:0071316)2.09400915
144negative regulation of potassium ion transmembrane transport (GO:1901380)2.07857900
145regulation of endothelial cell chemotaxis (GO:2001026)2.06121607
146apoptotic cell clearance (GO:0043277)2.05472630
147response to interleukin-15 (GO:0070672)2.04817933
148cytoplasmic mRNA processing body assembly (GO:0033962)2.03468281
149regulation of lipid storage (GO:0010883)2.03442568
150bundle of His cell to Purkinje myocyte communication (GO:0086069)2.01986191
151regulation of lipid catabolic process (GO:0050994)2.00393575
152negative regulation of potassium ion transmembrane transporter activity (GO:1901017)1.99806902
153regulation of skeletal muscle contraction (GO:0014819)1.99270282
154plasma membrane repair (GO:0001778)1.97937471
155negative regulation of cell killing (GO:0031342)1.97403820
156negative regulation of leukocyte mediated cytotoxicity (GO:0001911)1.97403820
157muscle filament sliding (GO:0030049)1.96734601
158actin-myosin filament sliding (GO:0033275)1.96734601
159positive regulation of fatty acid metabolic process (GO:0045923)1.96649705
160negative regulation of cholesterol transport (GO:0032375)1.96430222
161negative regulation of sterol transport (GO:0032372)1.96430222
162activation of MAPKKK activity (GO:0000185)1.96147100
163positive regulation of steroid biosynthetic process (GO:0010893)1.95671914
164protein carboxylation (GO:0018214)1.95574946
165peptidyl-glutamic acid carboxylation (GO:0017187)1.95574946
166regulation of triglyceride biosynthetic process (GO:0010866)1.95570433
167response to muramyl dipeptide (GO:0032495)1.94748519
168fatty acid beta-oxidation (GO:0006635)1.94415128
169dicarboxylic acid biosynthetic process (GO:0043650)1.93730861
170positive regulation of interleukin-2 production (GO:0032743)1.93582447
171regulation of NFAT protein import into nucleus (GO:0051532)1.93352396
172macroautophagy (GO:0016236)1.92834460
173carnitine transmembrane transport (GO:1902603)1.92369742
174positive regulation of glycolytic process (GO:0045821)1.91830441
175positive regulation of tolerance induction (GO:0002645)1.90156675

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.53480237
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.27066965
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.11872059
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.09363004
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.67983852
6RXR_22158963_ChIP-Seq_LIVER_Mouse2.61036392
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.59504211
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.54103731
9* LXR_22158963_ChIP-Seq_LIVER_Mouse2.47534445
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.44018335
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.40563842
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.18482529
13CLOCK_20551151_ChIP-Seq_293T_Human2.12661244
14* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.07915344
15RUNX_20019798_ChIP-Seq_JUKART_Human2.02364273
16* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.99272948
17EGR1_19374776_ChIP-ChIP_THP-1_Human1.90775342
18STAT6_21828071_ChIP-Seq_BEAS2B_Human1.90538686
19FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.88929747
20* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.82259706
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.78278368
22RARG_19884340_ChIP-ChIP_MEFs_Mouse1.71461030
23TRIM28_21343339_ChIP-Seq_HEK293_Human1.70955415
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.65121121
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.64630186
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.56580988
27KDM2B_26808549_Chip-Seq_DND41_Human1.56395981
28ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.55599810
29CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.54852827
30* TCF7_22412390_ChIP-Seq_EML_Mouse1.54816559
31SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.54784595
32BP1_19119308_ChIP-ChIP_Hs578T_Human1.54235043
33ESR1_20079471_ChIP-ChIP_T-47D_Human1.53518839
34* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.52845891
35TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52786603
36* MYC_22102868_ChIP-Seq_BL_Human1.51716366
37TBX20_22328084_ChIP-Seq_HEART_Mouse1.49999891
38TBX20_22080862_ChIP-Seq_HEART_Mouse1.49999891
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.46541040
40* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.46337142
41* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.45411295
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.44337074
43GATA1_22025678_ChIP-Seq_K562_Human1.43370036
44GATA2_21666600_ChIP-Seq_HMVEC_Human1.41429842
45NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40577226
46TP63_17297297_ChIP-ChIP_HaCaT_Human1.40214505
47IRF8_27001747_Chip-Seq_BMDM_Mouse1.35924383
48Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.34595981
49FOXA2_19822575_ChIP-Seq_HepG2_Human1.33231267
50MAF_26560356_Chip-Seq_TH1_Human1.32216590
51FOXO3_23340844_ChIP-Seq_DLD1_Human1.31385965
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.28467026
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26386782
54* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26094354
55* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25863738
56EP300_21415370_ChIP-Seq_HL-1_Mouse1.25512175
57GATA1_19941827_ChIP-Seq_MEL_Mouse1.25461004
58SCL_19346495_ChIP-Seq_HPC-7_Human1.25200931
59* RUNX1_22412390_ChIP-Seq_EML_Mouse1.25180648
60VDR_24787735_ChIP-Seq_THP-1_Human1.22258161
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.21910393
62KDM2B_26808549_Chip-Seq_JURKAT_Human1.21745144
63PU_27001747_Chip-Seq_BMDM_Mouse1.20759001
64* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18046134
65ESR1_21235772_ChIP-Seq_MCF-7_Human1.17985147
66ELK3_25401928_ChIP-Seq_HUVEC_Human1.16186491
67NFIB_24661679_ChIP-Seq_LUNG_Mouse1.15230931
68KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15190561
69RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13748909
70KDM2B_26808549_Chip-Seq_K562_Human1.13664030
71EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12373941
72* MAF_26560356_Chip-Seq_TH2_Human1.12068771
73* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11389946
74PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09055476
75BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08439123
76CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06278151
77VDR_24763502_ChIP-Seq_THP-1_Human1.05312169
78UTX_26944678_Chip-Seq_JUKART_Human1.05044557
79TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04937639
80CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04628413
81RXR_22108803_ChIP-Seq_LS180_Human1.04116979
82MYB_26560356_Chip-Seq_TH2_Human1.03683257
83SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02875641
84LXR_22292898_ChIP-Seq_THP-1_Human1.02554100
85VDR_21846776_ChIP-Seq_THP-1_Human1.02475442
86NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02428429
87* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01284364
88GATA1_19941826_ChIP-Seq_K562_Human1.01159236
89FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.00848436
90BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00529988
91RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00419681
92TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.00261786
93MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.99845517
94* SPI1_23127762_ChIP-Seq_K562_Human0.99458852
95IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99381026
96SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98352320
97EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97684166
98SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97374957
99P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97330205
100RACK7_27058665_Chip-Seq_MCF-7_Human0.97252303
101* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96783022
102ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96007964
103* GATA2_19941826_ChIP-Seq_K562_Human0.95901481
104GATA3_27048872_Chip-Seq_THYMUS_Human0.95356593
105STAT4_19710469_ChIP-ChIP_TH1__Mouse0.93999149
106CJUN_26792858_Chip-Seq_BT549_Human0.93610023
107PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93520317
108MYB_21317192_ChIP-Seq_ERMYB_Mouse0.93443496
109NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92867304
110TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92422434
111RUNX1_27514584_Chip-Seq_MCF-7_Human0.92146934
112GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91909380
113* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90026866
114HIF1A_21447827_ChIP-Seq_MCF-7_Human0.89901974
115MYB_26560356_Chip-Seq_TH1_Human0.89857097
116SPI1_23547873_ChIP-Seq_NB4_Human0.88251710
117ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.87949732
118* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.86682190
119MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.84843208
120STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.84269112
121GATA2_22383799_ChIP-Seq_G1ME_Mouse0.80219263

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004510_myositis3.19495877
2MP0003300_gastrointestinal_ulcer3.09439957
3MP0002837_dystrophic_cardiac_calcinosis2.80663934
4MP0003303_peritoneal_inflammation2.79424662
5MP0005451_abnormal_body_composition2.44197753
6MP0002139_abnormal_hepatobiliary_system2.43762939
7MP0002254_reproductive_system_inflammat2.37792809
8MP0002148_abnormal_hypersensitivity_rea2.30308302
9MP0005360_urolithiasis2.18176487
10MP0000685_abnormal_immune_system2.16507388
11MP0002138_abnormal_hepatobiliary_system2.12522131
12MP0001790_abnormal_immune_system2.10891318
13MP0005387_immune_system_phenotype2.10891318
14MP0004130_abnormal_muscle_cell2.02068450
15MP0005365_abnormal_bile_salt1.99693546
16MP0002877_abnormal_melanocyte_morpholog1.98394380
17MP0003436_decreased_susceptibility_to1.98027865
18MP0003252_abnormal_bile_duct1.90778784
19MP0006082_CNS_inflammation1.85681391
20MP0008961_abnormal_basal_metabolism1.84194688
21MP0003646_muscle_fatigue1.76470235
22MP0003705_abnormal_hypodermis_morpholog1.75572823
23MP0003172_abnormal_lysosome_physiology1.73257179
24MP0005058_abnormal_lysosome_morphology1.73007805
25MP0003183_abnormal_peptide_metabolism1.67599580
26MP0000751_myopathy1.67589062
27MP0003724_increased_susceptibility_to1.63454067
28MP0003690_abnormal_glial_cell1.63124749
29MP0004084_abnormal_cardiac_muscle1.61474127
30MP0002398_abnormal_bone_marrow1.57575800
31MP0005670_abnormal_white_adipose1.57385021
32MP0000716_abnormal_immune_system1.55568675
33MP0004087_abnormal_muscle_fiber1.55269246
34MP0001800_abnormal_humoral_immune1.52141205
35MP0004036_abnormal_muscle_relaxation1.51055171
36MP0002166_altered_tumor_susceptibility1.49872950
37MP0005666_abnormal_adipose_tissue1.49273523
38MP0004947_skin_inflammation1.47104201
39MP0010329_abnormal_lipoprotein_level1.46439226
40MP0001835_abnormal_antigen_presentation1.46000210
41MP0009333_abnormal_splenocyte_physiolog1.45450284
42MP0000749_muscle_degeneration1.42727037
43MP0002332_abnormal_exercise_endurance1.42596097
44MP0005000_abnormal_immune_tolerance1.40318848
45MP0005076_abnormal_cell_differentiation1.37830277
46MP0010368_abnormal_lymphatic_system1.35337913
47MP0005375_adipose_tissue_phenotype1.34224970
48MP0000733_abnormal_muscle_development1.33560791
49MP0009840_abnormal_foam_cell1.31431509
50MP0010630_abnormal_cardiac_muscle1.31309347
51MP0005310_abnormal_salivary_gland1.30548949
52MP0003191_abnormal_cellular_cholesterol1.30530930
53MP0000689_abnormal_spleen_morphology1.30421930
54MP0001853_heart_inflammation1.29066192
55MP0003763_abnormal_thymus_physiology1.28769888
56MP0000609_abnormal_liver_physiology1.28506241
57MP0003045_fibrosis1.26537384
58MP0009785_altered_susceptibility_to1.25380947
59MP0005085_abnormal_gallbladder_physiolo1.25164423
60MP0004381_abnormal_hair_follicle1.22349856
61MP0000858_altered_metastatic_potential1.21078855
62MP0005330_cardiomyopathy1.20946166
63MP0002722_abnormal_immune_system1.20906866
64MP0000703_abnormal_thymus_morphology1.20324472
65MP0005167_abnormal_blood-brain_barrier1.20147011
66MP0003566_abnormal_cell_adhesion1.19806500
67MP0008875_abnormal_xenobiotic_pharmacok1.18733029
68MP0000750_abnormal_muscle_regeneration1.18697703
69MP0003656_abnormal_erythrocyte_physiolo1.18568400
70MP0004185_abnormal_adipocyte_glucose1.17740022
71MP0003828_pulmonary_edema1.17733251
72MP0001533_abnormal_skeleton_physiology1.15644017
73MP0002452_abnormal_antigen_presenting1.13530537
74MP0002972_abnormal_cardiac_muscle1.12746609
75MP0002723_abnormal_immune_serum1.12689309
76MP0000003_abnormal_adipose_tissue1.11545921
77MP0002429_abnormal_blood_cell1.11526619
78MP0003091_abnormal_cell_migration1.10842086
79MP0002933_joint_inflammation1.09851579
80MP0005671_abnormal_response_to1.08863171
81MP0003453_abnormal_keratinocyte_physiol1.08167391
82MP0002971_abnormal_brown_adipose1.07108712
83MP0009764_decreased_sensitivity_to1.07066013
84MP0002106_abnormal_muscle_physiology1.06183523
85MP0010155_abnormal_intestine_physiology1.05627270
86MP0009278_abnormal_bone_marrow1.05019616
87MP0006054_spinal_hemorrhage1.03935105
88MP0002006_tumorigenesis1.03608149
89MP0002118_abnormal_lipid_homeostasis1.03427982
90MP0004264_abnormal_extraembryonic_tissu1.03002929
91MP0002405_respiratory_system_inflammati1.02917989
92MP0002419_abnormal_innate_immunity1.02294209
93MP0002998_abnormal_bone_remodeling1.02094190
94MP0005166_decreased_susceptibility_to1.01724652
95MP0005025_abnormal_response_to1.00539963
96MP0003866_abnormal_defecation0.99630148
97MP0000759_abnormal_skeletal_muscle0.99075734
98MP0001845_abnormal_inflammatory_respons0.99016465
99MP0001851_eye_inflammation0.98774702
100MP0004883_abnormal_blood_vessel0.98672598
101MP0009780_abnormal_chondrocyte_physiolo0.98044556
102MP0005620_abnormal_muscle_contractility0.97898691
103MP0003279_aneurysm0.97118913
104MP0001879_abnormal_lymphatic_vessel0.96933821
105MP0002168_other_aberrant_phenotype0.96800507
106MP0000604_amyloidosis0.95693941
107MP0008004_abnormal_stomach_pH0.95511324
108MP0004215_abnormal_myocardial_fiber0.93993553
109MP0005385_cardiovascular_system_phenoty0.93893525
110MP0001544_abnormal_cardiovascular_syste0.93893525
111MP0000249_abnormal_blood_vessel0.93893307
112MP0002420_abnormal_adaptive_immunity0.92182402
113MP0005319_abnormal_enzyme/_coenzyme0.91925687
114MP0000465_gastrointestinal_hemorrhage0.91612608
115MP0005464_abnormal_platelet_physiology0.91591401
116MP0003195_calcinosis0.91267384
117MP0008260_abnormal_autophagy0.90712723
118MP0001819_abnormal_immune_cell0.90663583
119MP0003448_altered_tumor_morphology0.90563274
120MP0002234_abnormal_pharynx_morphology0.89411463
121MP0005248_abnormal_Harderian_gland0.88787020
122MP0000767_abnormal_smooth_muscle0.87436284
123MP0000920_abnormal_myelination0.87175706
124MP0002269_muscular_atrophy0.86690149
125MP0008775_abnormal_heart_ventricle0.86052355
126MP0005369_muscle_phenotype0.84594601
127MP0000747_muscle_weakness0.83563366
128MP0005334_abnormal_fat_pad0.83504535
129MP0008469_abnormal_protein_level0.83205735
130MP0001873_stomach_inflammation0.83095735
131MP0005023_abnormal_wound_healing0.82850194
132MP0005164_abnormal_response_to0.82485353
133MP0002078_abnormal_glucose_homeostasis0.82183708
134MP0002909_abnormal_adrenal_gland0.81887620
135MP0002009_preneoplasia0.81473466
136MP0003075_altered_response_to0.80694449
137MP0001915_intracranial_hemorrhage0.80312786
138MP0003221_abnormal_cardiomyocyte_apopto0.79290257
139MP0004233_abnormal_muscle_weight0.76919018
140MP0005397_hematopoietic_system_phenotyp0.76239661
141MP0001545_abnormal_hematopoietic_system0.76239661
142MP0004808_abnormal_hematopoietic_stem0.74408918
143MP0009115_abnormal_fat_cell0.72063928
144MP0003868_abnormal_feces_composition0.71906739
145MP0009763_increased_sensitivity_to0.69534597
146MP0001663_abnormal_digestive_system0.68412471

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)3.44858926
2Exercise-induced myalgia (HP:0003738)3.42550720
3T lymphocytopenia (HP:0005403)3.21852512
4Mediastinal lymphadenopathy (HP:0100721)3.21783697
5Hyporeflexia of lower limbs (HP:0002600)3.16398800
6Right ventricular cardiomyopathy (HP:0011663)3.16030687
7Myocardial infarction (HP:0001658)3.12583455
8Glomerulonephritis (HP:0000099)3.11023405
9Keratoconjunctivitis sicca (HP:0001097)3.04356325
10Meningitis (HP:0001287)3.01590002
11Sudden death (HP:0001699)2.96727833
12Abnormality of macrophages (HP:0004311)2.96114999
13Muscle fiber splitting (HP:0003555)2.92953699
14Eczematoid dermatitis (HP:0000976)2.81899554
15Mitral stenosis (HP:0001718)2.80696931
16Asymmetric septal hypertrophy (HP:0001670)2.79350833
17Increased density of long bones (HP:0006392)2.78780915
18Calf muscle hypertrophy (HP:0008981)2.73576674
19Exercise-induced muscle cramps (HP:0003710)2.72957461
20Abnormality of the left ventricular outflow tract (HP:0011103)2.70531834
21Subaortic stenosis (HP:0001682)2.70531834
22Increased connective tissue (HP:0009025)2.70053876
23Ventricular tachycardia (HP:0004756)2.69866456
24Persistence of primary teeth (HP:0006335)2.69082625
25Keratoconjunctivitis (HP:0001096)2.64570470
26Agammaglobulinemia (HP:0004432)2.64475527
27Myoglobinuria (HP:0002913)2.60036958
28Difficulty running (HP:0009046)2.58367823
29Recurrent bacterial skin infections (HP:0005406)2.57868485
30Hypoglycemic coma (HP:0001325)2.57577342
31Deep venous thrombosis (HP:0002625)2.55354860
32Pulmonary infiltrates (HP:0002113)2.52884813
33Ketoacidosis (HP:0001993)2.50299354
34Hemorrhage of the eye (HP:0011885)2.49720374
35Recurrent abscess formation (HP:0002722)2.48475098
36Abnormality of the calf musculature (HP:0001430)2.44397173
37Recurrent viral infections (HP:0004429)2.42500173
38Increased IgE level (HP:0003212)2.41843546
39Recurrent bronchitis (HP:0002837)2.40860079
40Muscle hypertrophy of the lower extremities (HP:0008968)2.39670391
41Cellulitis (HP:0100658)2.38631440
42Broad metatarsal (HP:0001783)2.37995179
43Autoimmune hemolytic anemia (HP:0001890)2.35333973
44Pulmonary embolism (HP:0002204)2.32685230
45Type 1 muscle fiber predominance (HP:0003803)2.29121908
46Xanthomatosis (HP:0000991)2.24354866
47Loss of speech (HP:0002371)2.23111107
48Gangrene (HP:0100758)2.22527083
49Dysostosis multiplex (HP:0000943)2.21759503
50Abnormality of the pleura (HP:0002103)2.20606303
51Autoimmune thrombocytopenia (HP:0001973)2.20533409
52Joint hemorrhage (HP:0005261)2.19534238
53Ketosis (HP:0001946)2.18977130
54Segmental peripheral demyelination/remyelination (HP:0003481)2.18134747
55Arterial thrombosis (HP:0004420)2.17998167
56Abnormal delayed hypersensitivity skin test (HP:0002963)2.17439445
57EMG: myopathic abnormalities (HP:0003458)2.17417710
58Encephalitis (HP:0002383)2.17331884
59Abnormality of proline metabolism (HP:0010907)2.15726461
60Hydroxyprolinuria (HP:0003080)2.15726461
61Abnormality of complement system (HP:0005339)2.15657988
62Abnormality of B cell number (HP:0010975)2.15551919
63Lipoatrophy (HP:0100578)2.14349544
64Esophageal varix (HP:0002040)2.13524884
65Gastrointestinal inflammation (HP:0004386)2.12911478
66Frequent falls (HP:0002359)2.12626785
67Inflammation of the large intestine (HP:0002037)2.11165504
68Atrial fibrillation (HP:0005110)2.10948831
69Interstitial pulmonary disease (HP:0006530)2.09000383
70Bundle branch block (HP:0011710)2.08284305
71Joint swelling (HP:0001386)2.04916652
72Lymphopenia (HP:0001888)2.04855995
73Hyperglycemia (HP:0003074)2.03621149
74Aneurysm (HP:0002617)2.03538113
75Aortic aneurysm (HP:0004942)2.03276578
76Obstructive sleep apnea (HP:0002870)2.01974178
77Abnormality of glutamine family amino acid metabolism (HP:0010902)2.01917320
78Abnormality of the common coagulation pathway (HP:0010990)2.00029259
79Restrictive lung disease (HP:0002091)1.99871885
80Stomatitis (HP:0010280)1.99823702
81Scapular winging (HP:0003691)1.99646081
82Panhypogammaglobulinemia (HP:0003139)1.98620553
83Prolonged partial thromboplastin time (HP:0003645)1.98318768
84Slow saccadic eye movements (HP:0000514)1.97432968
85B lymphocytopenia (HP:0010976)1.96590411
86Gastrointestinal stroma tumor (HP:0100723)1.96571832
87Orchitis (HP:0100796)1.95732527
88Primary atrial arrhythmia (HP:0001692)1.95586163
89Neurofibrillary tangles (HP:0002185)1.95412262
90Purpura (HP:0000979)1.95041732
91Abnormality of the fingertips (HP:0001211)1.94888512
92Abnormality of cells of the lymphoid lineage (HP:0012140)1.93816813
93Colitis (HP:0002583)1.93167952
94Gingivitis (HP:0000230)1.91724047
95Mucopolysacchariduria (HP:0008155)1.91704066
96Urinary glycosaminoglycan excretion (HP:0003541)1.91704066
97Hemoptysis (HP:0002105)1.91493476
98Osteomyelitis (HP:0002754)1.91296234
99Recurrent gram-negative bacterial infections (HP:0005420)1.90950958
100Nephritis (HP:0000123)1.90117072
101Spontaneous hematomas (HP:0007420)1.90028142
102Gastrointestinal infarctions (HP:0005244)1.89866542
103Cerebral aneurysm (HP:0004944)1.89785513
104Sepsis (HP:0100806)1.89101598
105Striae distensae (HP:0001065)1.88732173
106Polycythemia (HP:0001901)1.87780582
107Abnormality of polysaccharide metabolism (HP:0011012)1.86516194
108Abnormality of glycosaminoglycan metabolism (HP:0004371)1.86516194
109Abnormality of mucopolysaccharide metabolism (HP:0011020)1.86516194
110Amyloidosis (HP:0011034)1.86298364
111Macroorchidism (HP:0000053)1.85759262
112Chest pain (HP:0100749)1.85365280
113Papilloma (HP:0012740)1.85290960
114Verrucae (HP:0200043)1.85290960
115Hypoplasia of the thymus (HP:0000778)1.84785166
116Increased IgM level (HP:0003496)1.84264610
117Hyperinsulinemic hypoglycemia (HP:0000825)1.83701505
118Abnormality of the peritoneum (HP:0002585)1.83112636
119Atrioventricular block (HP:0001678)1.82897220
120Hypoalphalipoproteinemia (HP:0003233)1.82743403
121Recurrent fungal infections (HP:0002841)1.82570334
122Polyneuropathy (HP:0001271)1.82554867
123Epidermoid cyst (HP:0200040)1.81175743
124Subacute progressive viral hepatitis (HP:0006572)1.80676512
125Dysmetric saccades (HP:0000641)1.79459129
126Peritonitis (HP:0002586)1.78684146
127Recurrent skin infections (HP:0001581)1.78212047
128Abnormality of the endocardium (HP:0004306)1.77679191
129Supraventricular tachycardia (HP:0004755)1.76835499
130Severe combined immunodeficiency (HP:0004430)1.76590183
131Complement deficiency (HP:0004431)1.76405920
132Abnormality of glycolipid metabolism (HP:0010969)1.76356606
133Abnormality of liposaccharide metabolism (HP:0010968)1.76356606
134Abnormality of glycosphingolipid metabolism (HP:0004343)1.76356606
135Dilated cardiomyopathy (HP:0001644)1.75795031
136Supraventricular arrhythmia (HP:0005115)1.74916771
137Hypoplastic ischia (HP:0003175)1.74906342
138Increased cerebral lipofuscin (HP:0011813)1.74556448
139Intrahepatic cholestasis (HP:0001406)1.74370009
140Retrobulbar optic neuritis (HP:0100654)1.74215970
141Optic neuritis (HP:0100653)1.74215970
142Increased variability in muscle fiber diameter (HP:0003557)1.74141594
143Distal lower limb amyotrophy (HP:0008944)1.72328029
144Syncope (HP:0001279)1.72240166
145Difficulty climbing stairs (HP:0003551)1.72082077
146Mitral valve prolapse (HP:0001634)1.71877011
147Abnormality of T cells (HP:0002843)1.70865987
148Eosinophilia (HP:0001880)1.70550301
149Mildly elevated creatine phosphokinase (HP:0008180)1.70456740
150Abnormality of aromatic amino acid family metabolism (HP:0004338)1.70197838
151Viral hepatitis (HP:0006562)1.69601288
152Asymmetry of the thorax (HP:0001555)1.69300259
153Hypoglycemic seizures (HP:0002173)1.68987608
154Periodontitis (HP:0000704)1.68887277
155Myositis (HP:0100614)1.68435439
156Muscle fiber inclusion bodies (HP:0100299)1.67703977
157Abnormality of T cell number (HP:0011839)1.66826435
158Prolonged QT interval (HP:0001657)1.66647203
159Abnormal atrioventricular conduction (HP:0005150)1.66230206
160Ventricular arrhythmia (HP:0004308)1.66109234
161Heart block (HP:0012722)1.65710516
162Abnormality of skeletal muscle fiber size (HP:0012084)1.64820600
163Vasculitis (HP:0002633)1.64466623
164Gingival bleeding (HP:0000225)1.63790405
165Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.63596648
166Emphysema (HP:0002097)1.63582508
167Hematochezia (HP:0002573)1.63009164
168Abnormality of monocarboxylic acid metabolism (HP:0010996)1.62730536
169Limb-girdle muscle atrophy (HP:0003797)1.61127211
170Tetraparesis (HP:0002273)1.60943413

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.54868151
2SIK12.68816675
3FGFR42.60963689
4EPHB12.53416628
5PRPF4B2.48582212
6MAP3K142.46155572
7ERN12.44660854
8TTN2.43496250
9MAP4K12.42663752
10RIPK12.24689193
11EPHA32.15089595
12MAP3K102.09341133
13JAK11.98168803
14RIPK41.86680354
15IRAK41.83578237
16TBK11.82782144
17BLK1.82758344
18PKN21.73952232
19FGFR31.73067688
20JAK31.68377783
21DMPK1.64230982
22CHUK1.63536066
23PTK61.58019708
24MAP3K71.55179335
25TYK21.53928136
26LMTK21.52468681
27IKBKE1.41253432
28ICK1.38273870
29PHKG11.35784507
30PHKG21.35784507
31TXK1.25718333
32IKBKB1.25019020
33INSRR1.22774608
34SMG11.21844019
35TAOK21.18965770
36SGK31.18052178
37ITK1.17249554
38IRAK31.17225549
39PRKCH1.16681720
40TYRO31.15168372
41FGR1.13173257
42KSR21.13035307
43GRK61.08689120
44MATK1.08382106
45MAP3K31.06113357
46TNK21.05562703
47FES1.05362414
48MARK21.04351521
49LRRK21.02874077
50CSF1R1.02565600
51OBSCN1.02559537
52TAOK11.02068703
53CAMK1G1.01997183
54MAPK71.01993677
55FGFR21.01982045
56CSK1.00348837
57CAMK1D1.00329189
58HIPK20.99456444
59TAOK30.99364378
60DDR20.98800888
61BMX0.98396986
62TGFBR20.96274494
63JAK20.95543441
64MAP3K130.94836869
65CDK40.94024726
66EEF2K0.92544942
67ZAP700.91722582
68PDGFRA0.90895408
69LATS10.90823973
70MAPK150.90508444
71HCK0.86384257
72IRAK10.83768035
73LYN0.83747481
74CDK120.83134565
75NLK0.82151270
76STK100.81104006
77BTK0.78632131
78IRAK20.78211790
79RPS6KA40.76909063
80PDGFRB0.75419784
81SGK20.74055877
82MAP3K110.73332035
83PRKD10.71918311
84MAPK40.71126642
85GSK3A0.70474901
86MAP3K20.70441745
87MTOR0.69999660
88MAP3K10.69316465
89BRD40.68478042
90MAP2K30.67684346
91PRKAA20.66287906
92PIK3CA0.64588694
93PDK10.63375769
94GRK70.62466292
95FRK0.61895350
96PRKCQ0.59619088
97MAPKAPK20.58820949
98MAP2K20.57776393
99SYK0.57006190
100RET0.56592543
101PAK30.56516833
102SIK20.55229826
103MAPK110.55165094
104NEK90.54095091
105PTK20.53358326
106BMPR20.53256688
107MARK30.52838714
108ALK0.52541140
109RPS6KC10.52214159
110RPS6KL10.52214159
111PIK3CG0.51140796
112SIK30.50789657
113MELK0.49630147
114FGFR10.49409652
115CDK60.49223000
116PKN10.48905857
117MST1R0.48443037
118SGK4940.48420994
119SGK2230.48420994
120MOS0.47019513
121PRKAA10.46753236
122CAMK40.46674260
123RPS6KA10.45964772
124PRKD20.45308138
125CDC42BPA0.45178723
126KSR10.43999846
127MAPK120.42368530
128STK240.42356630
129BCKDK0.42250856
130PDPK10.41453030
131DYRK1B0.40917330
132EPHB20.40687426
133LCK0.40138795
134SGK10.38672233
135WNK10.38659468

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.47673238
2Nitrogen metabolism_Homo sapiens_hsa009102.10633238
3NF-kappa B signaling pathway_Homo sapiens_hsa040641.79573209
4Fatty acid degradation_Homo sapiens_hsa000711.71802671
5Adipocytokine signaling pathway_Homo sapiens_hsa049201.65882765
6Insulin resistance_Homo sapiens_hsa049311.64771806
7Osteoclast differentiation_Homo sapiens_hsa043801.58002671
8Leishmaniasis_Homo sapiens_hsa051401.54846616
9Autoimmune thyroid disease_Homo sapiens_hsa053201.47312112
10Other glycan degradation_Homo sapiens_hsa005111.44206777
11PPAR signaling pathway_Homo sapiens_hsa033201.42719280
12Primary bile acid biosynthesis_Homo sapiens_hsa001201.42541865
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.37527795
14B cell receptor signaling pathway_Homo sapiens_hsa046621.37133956
15Arginine biosynthesis_Homo sapiens_hsa002201.33833490
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33699359
17TNF signaling pathway_Homo sapiens_hsa046681.33516992
18Staphylococcus aureus infection_Homo sapiens_hsa051501.30494473
19Fatty acid metabolism_Homo sapiens_hsa012121.29020608
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.25172879
21Tryptophan metabolism_Homo sapiens_hsa003801.24288882
22Viral myocarditis_Homo sapiens_hsa054161.24015889
23Type II diabetes mellitus_Homo sapiens_hsa049301.23495712
24Lysine degradation_Homo sapiens_hsa003101.22693095
25Herpes simplex infection_Homo sapiens_hsa051681.22530104
26Toxoplasmosis_Homo sapiens_hsa051451.21814168
27Dilated cardiomyopathy_Homo sapiens_hsa054141.21038676
28Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.19745542
29T cell receptor signaling pathway_Homo sapiens_hsa046601.19527431
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.15429363
31Propanoate metabolism_Homo sapiens_hsa006401.13898299
32Prion diseases_Homo sapiens_hsa050201.13251187
33Caffeine metabolism_Homo sapiens_hsa002321.12771832
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12733645
35Prostate cancer_Homo sapiens_hsa052151.08933285
36Acute myeloid leukemia_Homo sapiens_hsa052211.06465495
37Prolactin signaling pathway_Homo sapiens_hsa049171.05751394
38Chronic myeloid leukemia_Homo sapiens_hsa052201.04631410
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03792210
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02146479
41Complement and coagulation cascades_Homo sapiens_hsa046101.00972100
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00117591
43Asthma_Homo sapiens_hsa053100.98692893
44NOD-like receptor signaling pathway_Homo sapiens_hsa046210.98305639
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.97063548
46Measles_Homo sapiens_hsa051620.96998083
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95879882
48Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95229776
49Primary immunodeficiency_Homo sapiens_hsa053400.94820144
50Jak-STAT signaling pathway_Homo sapiens_hsa046300.94628923
51VEGF signaling pathway_Homo sapiens_hsa043700.93552972
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92244475
53Antigen processing and presentation_Homo sapiens_hsa046120.91945561
54Starch and sucrose metabolism_Homo sapiens_hsa005000.89384812
55Intestinal immune network for IgA production_Homo sapiens_hsa046720.88761384
56Butanoate metabolism_Homo sapiens_hsa006500.86927685
57Amoebiasis_Homo sapiens_hsa051460.85086185
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82876012
59Allograft rejection_Homo sapiens_hsa053300.82776931
60Malaria_Homo sapiens_hsa051440.81420128
61Legionellosis_Homo sapiens_hsa051340.80767315
62Bladder cancer_Homo sapiens_hsa052190.80282073
63Insulin signaling pathway_Homo sapiens_hsa049100.79853274
64Graft-versus-host disease_Homo sapiens_hsa053320.79224849
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.78045457
66Colorectal cancer_Homo sapiens_hsa052100.76558155
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76374760
68Rheumatoid arthritis_Homo sapiens_hsa053230.76187150
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.75341799
70Glioma_Homo sapiens_hsa052140.75277137
71ABC transporters_Homo sapiens_hsa020100.75087196
72HIF-1 signaling pathway_Homo sapiens_hsa040660.74902429
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.74797130
74Circadian rhythm_Homo sapiens_hsa047100.74035295
75Focal adhesion_Homo sapiens_hsa045100.72258379
76Chemokine signaling pathway_Homo sapiens_hsa040620.71912193
77Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70941180
78Proteoglycans in cancer_Homo sapiens_hsa052050.70580944
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.70475327
80Bile secretion_Homo sapiens_hsa049760.70367585
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69766670
82Small cell lung cancer_Homo sapiens_hsa052220.69170373
83Epstein-Barr virus infection_Homo sapiens_hsa051690.68344668
84Phenylalanine metabolism_Homo sapiens_hsa003600.68262897
85Platelet activation_Homo sapiens_hsa046110.68128696
86beta-Alanine metabolism_Homo sapiens_hsa004100.68041523
87Hepatitis C_Homo sapiens_hsa051600.67902067
88Tuberculosis_Homo sapiens_hsa051520.67524552
89Lysosome_Homo sapiens_hsa041420.67402742
90Influenza A_Homo sapiens_hsa051640.67186958
91Salmonella infection_Homo sapiens_hsa051320.67090541
92Pancreatic cancer_Homo sapiens_hsa052120.66132297
93Dorso-ventral axis formation_Homo sapiens_hsa043200.65969221
94Choline metabolism in cancer_Homo sapiens_hsa052310.65812805
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65331911
96ErbB signaling pathway_Homo sapiens_hsa040120.65010097
97Type I diabetes mellitus_Homo sapiens_hsa049400.64677287
98Hepatitis B_Homo sapiens_hsa051610.64511524
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.64014029
100Glucagon signaling pathway_Homo sapiens_hsa049220.63886221
101Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63117622
102HTLV-I infection_Homo sapiens_hsa051660.62079070
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62019574
104AMPK signaling pathway_Homo sapiens_hsa041520.61828329
105Estrogen signaling pathway_Homo sapiens_hsa049150.61639616
106Thyroid cancer_Homo sapiens_hsa052160.61363883
107mTOR signaling pathway_Homo sapiens_hsa041500.60453684
108Adherens junction_Homo sapiens_hsa045200.59977969
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59648686
110Pertussis_Homo sapiens_hsa051330.59512613
111FoxO signaling pathway_Homo sapiens_hsa040680.59120390
112Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58899789
113Notch signaling pathway_Homo sapiens_hsa043300.57351086
114Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57110255
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55605275
116Apoptosis_Homo sapiens_hsa042100.55154743
117Fatty acid biosynthesis_Homo sapiens_hsa000610.55005948
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54671997
119Viral carcinogenesis_Homo sapiens_hsa052030.53019692
120Peroxisome_Homo sapiens_hsa041460.52419661
121GnRH signaling pathway_Homo sapiens_hsa049120.52281406
122MicroRNAs in cancer_Homo sapiens_hsa052060.51692395
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51662975
124African trypanosomiasis_Homo sapiens_hsa051430.49582183
125Renal cell carcinoma_Homo sapiens_hsa052110.48835515
126Shigellosis_Homo sapiens_hsa051310.48809720
127Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48305987
128Hematopoietic cell lineage_Homo sapiens_hsa046400.47583227
129MAPK signaling pathway_Homo sapiens_hsa040100.45746644
130Maturity onset diabetes of the young_Homo sapiens_hsa049500.45528524
131Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45239359
132Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45239261
133Non-small cell lung cancer_Homo sapiens_hsa052230.45206473
134Glycerolipid metabolism_Homo sapiens_hsa005610.43856370
135Endometrial cancer_Homo sapiens_hsa052130.43797906

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