ZHX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 1 of this gene family. In addition to forming homodimers, this protein heterodimerizes with members 2 and 3 of the zinc fingers and homeoboxes family. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 8 open reading frame 76 (C8orf76) gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of mitochondrial fission (GO:0090141)4.22252010
2cytoplasmic mRNA processing body assembly (GO:0033962)3.77673920
3COPI coating of Golgi vesicle (GO:0048205)3.53335400
4Golgi transport vesicle coating (GO:0048200)3.53335400
5negative regulation of neurotransmitter secretion (GO:0046929)3.31673037
6regulation of synaptic vesicle exocytosis (GO:2000300)3.29698875
7Golgi to endosome transport (GO:0006895)3.23696272
8activation of protein kinase A activity (GO:0034199)3.20768291
9locomotory exploration behavior (GO:0035641)3.08554624
10embryonic retina morphogenesis in camera-type eye (GO:0060059)3.01302262
11positive regulation of CREB transcription factor activity (GO:0032793)2.96180831
12regulation of synaptic vesicle transport (GO:1902803)2.95691003
13alpha-linolenic acid metabolic process (GO:0036109)2.95093472
14regulation of mitochondrial fission (GO:0090140)2.93278708
15gamma-aminobutyric acid transport (GO:0015812)2.88810361
16positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.86800744
17membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.86592128
18regulation of short-term neuronal synaptic plasticity (GO:0048172)2.86463721
19synaptic vesicle exocytosis (GO:0016079)2.85147388
20exocrine pancreas development (GO:0031017)2.84476985
21pyrimidine nucleobase catabolic process (GO:0006208)2.83119002
22piRNA metabolic process (GO:0034587)2.81931110
23positive regulation of fatty acid beta-oxidation (GO:0032000)2.77718810
24response to lipoprotein particle (GO:0055094)2.76868367
25regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.75395986
26antigen processing and presentation via MHC class Ib (GO:0002475)2.74104159
27retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.73690150
28cell morphogenesis involved in neuron differentiation (GO:0048667)2.72487724
29positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.72121769
30protein localization to synapse (GO:0035418)2.71534628
31regulation of glutamate receptor signaling pathway (GO:1900449)2.70120726
32biotin metabolic process (GO:0006768)2.69868911
33regulation of synapse structural plasticity (GO:0051823)2.66568138
34retrograde transport, vesicle recycling within Golgi (GO:0000301)2.65208072
35tricarboxylic acid cycle (GO:0006099)2.62948906
36neurotransmitter secretion (GO:0007269)2.61963258
37antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.61198701
38succinate metabolic process (GO:0006105)2.60978829
39positive regulation of glycolytic process (GO:0045821)2.60875290
40positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.60688620
41positive regulation of growth hormone secretion (GO:0060124)2.59990804
42regulation of protein glycosylation (GO:0060049)2.59671906
43response to pheromone (GO:0019236)2.59043934
44detection of calcium ion (GO:0005513)2.58633587
45exploration behavior (GO:0035640)2.58441692
46regulation of ARF protein signal transduction (GO:0032012)2.57376016
47intra-Golgi vesicle-mediated transport (GO:0006891)2.57153525
48regulation of pigment cell differentiation (GO:0050932)2.55626179
49lipid particle organization (GO:0034389)2.52618935
50cellular potassium ion homeostasis (GO:0030007)2.52055235
51regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.51947580
52potassium ion import (GO:0010107)2.51081100
53synaptic vesicle maturation (GO:0016188)2.50542726
54protein targeting to lysosome (GO:0006622)2.50517451
55establishment of protein localization to vacuole (GO:0072666)2.50517451
56protein targeting to vacuole (GO:0006623)2.50517451
57neurotransmitter-gated ion channel clustering (GO:0072578)2.49926615
58layer formation in cerebral cortex (GO:0021819)2.48282008
59nucleobase catabolic process (GO:0046113)2.47994044
60L-fucose catabolic process (GO:0042355)2.47482359
61fucose catabolic process (GO:0019317)2.47482359
62L-fucose metabolic process (GO:0042354)2.47482359
63righting reflex (GO:0060013)2.47253958
64COPII vesicle coating (GO:0048208)2.45424729
65axonal fasciculation (GO:0007413)2.45307631
66regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.44726262
67insulin secretion (GO:0030073)2.44053943
68glutamate secretion (GO:0014047)2.43460591
69regulation of long-term neuronal synaptic plasticity (GO:0048169)2.43283638
70negative regulation of cytosolic calcium ion concentration (GO:0051481)2.42981468
71regulation of cAMP-dependent protein kinase activity (GO:2000479)2.42579126
72microtubule anchoring (GO:0034453)2.42473454
73cell communication by electrical coupling (GO:0010644)2.42425178
74positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.41883865
75negative regulation of neurotransmitter transport (GO:0051589)2.41163435
76cerebral cortex radially oriented cell migration (GO:0021799)2.40763877
77synaptic vesicle docking involved in exocytosis (GO:0016081)2.40735326
78DNA methylation involved in gamete generation (GO:0043046)2.40695878
79cellular response to glucagon stimulus (GO:0071377)2.40092178
80positive regulation of DNA-templated transcription, initiation (GO:2000144)2.38607126
81positive regulation of fatty acid oxidation (GO:0046321)2.38381996
82peroxisome fission (GO:0016559)2.38331828
83lactate metabolic process (GO:0006089)2.37030242
84cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.36181354
85positive regulation of glycogen biosynthetic process (GO:0045725)2.35645230
86interkinetic nuclear migration (GO:0022027)2.33448490
87regulation of neuronal synaptic plasticity (GO:0048168)2.32215175
88nerve growth factor signaling pathway (GO:0038180)2.30957380
89regulation of Rac protein signal transduction (GO:0035020)2.30820967
90positive regulation of protein autophosphorylation (GO:0031954)2.30349495
91establishment of nucleus localization (GO:0040023)2.29333027
92vocalization behavior (GO:0071625)2.29140556
93positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.28360579
94neuron recognition (GO:0008038)2.27699639
95proline transport (GO:0015824)2.27694018
96vesicle coating (GO:0006901)2.27455154
97catecholamine transport (GO:0051937)2.27110847
98insulin-like growth factor receptor signaling pathway (GO:0048009)2.26981973
99regulation of RNA export from nucleus (GO:0046831)2.26793985
100regulation of glycogen (starch) synthase activity (GO:2000465)2.26154077
101monoubiquitinated protein deubiquitination (GO:0035520)2.25626482
102sodium ion export (GO:0071436)2.25552212
103protein targeting to Golgi (GO:0000042)2.24378823
104dendrite morphogenesis (GO:0048813)2.23586670
105positive regulation of dendritic spine morphogenesis (GO:0061003)2.22919707
106fucosylation (GO:0036065)2.22911689
107protein localization to Golgi apparatus (GO:0034067)2.22156427
108vesicle transport along microtubule (GO:0047496)2.22001171
109innervation (GO:0060384)2.21956752
110regulation of growth hormone secretion (GO:0060123)2.21631216
111auditory behavior (GO:0031223)2.20268307
112gene silencing by RNA (GO:0031047)2.20179201
113regulation of dendritic spine morphogenesis (GO:0061001)2.19793845
114cerebellar Purkinje cell differentiation (GO:0021702)2.19604010
115sympathetic nervous system development (GO:0048485)2.19399940
116regulation of fatty acid beta-oxidation (GO:0031998)2.19051093
117endoplasmic reticulum organization (GO:0007029)2.18667850
118positive regulation of muscle hypertrophy (GO:0014742)2.18628579
119positive regulation of cardiac muscle hypertrophy (GO:0010613)2.18628579
120relaxation of smooth muscle (GO:0044557)2.18507133
121Golgi to plasma membrane protein transport (GO:0043001)2.18287204
122Sertoli cell development (GO:0060009)2.17914159
123regulation of dendritic spine development (GO:0060998)2.16983804
124auditory receptor cell differentiation (GO:0042491)2.16820536
125positive regulation of dendritic spine development (GO:0060999)2.16781102
126establishment of protein localization to Golgi (GO:0072600)2.16518092
127ribonucleoprotein complex disassembly (GO:0032988)2.15390944
128ER overload response (GO:0006983)2.15140429
129nuclear pore organization (GO:0006999)2.13601364
130central nervous system projection neuron axonogenesis (GO:0021952)2.13362217
131establishment of mitochondrion localization (GO:0051654)2.13317747
132short-chain fatty acid metabolic process (GO:0046459)2.13317214
133omega-hydroxylase P450 pathway (GO:0097267)2.12504583
134positive regulation of glycogen metabolic process (GO:0070875)2.12252095
135synaptic vesicle endocytosis (GO:0048488)2.12103429
136retinal cone cell development (GO:0046549)2.11848952
137mechanosensory behavior (GO:0007638)2.11503049
138nucleus localization (GO:0051647)2.11470441
139inositol metabolic process (GO:0006020)2.11339371
140fatty acid homeostasis (GO:0055089)2.09855288
141negative regulation of sodium ion transport (GO:0010766)2.09826811
142valine metabolic process (GO:0006573)2.09772892
143neuronal action potential propagation (GO:0019227)2.08515842
144cellular sodium ion homeostasis (GO:0006883)2.08190983
145erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.06483117
146L-phenylalanine catabolic process (GO:0006559)2.06483117
147fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.05635033
148signal release (GO:0023061)2.05064283
149tricarboxylic acid metabolic process (GO:0072350)2.04806188
150type B pancreatic cell development (GO:0003323)2.03875362
151protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.02923404
152cellular zinc ion homeostasis (GO:0006882)2.02907161
153positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.02766160
154mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.02766160
155meiotic cell cycle (GO:0051321)2.01951314
156organelle transport along microtubule (GO:0072384)2.01947643
157long-term synaptic potentiation (GO:0060291)2.00918107
158regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)1.99535628
159regulation of synaptic transmission, glutamatergic (GO:0051966)1.99070909
160Golgi to plasma membrane transport (GO:0006893)1.98952579
161C4-dicarboxylate transport (GO:0015740)1.98530412
162clathrin coat assembly (GO:0048268)1.97863781
163positive regulation of potassium ion transport (GO:0043268)1.97613584
164ionotropic glutamate receptor signaling pathway (GO:0035235)1.97462333
165response to vitamin E (GO:0033197)1.97127793
166neuronal action potential (GO:0019228)1.96883559
167positive regulation of insulin secretion (GO:0032024)1.96747533
168regulation of timing of cell differentiation (GO:0048505)1.95728946
169central nervous system neuron axonogenesis (GO:0021955)1.95277339
170auditory receptor cell stereocilium organization (GO:0060088)1.94570981
171protein polyglutamylation (GO:0018095)1.94317790
172calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)1.93765584
173mitochondrion transport along microtubule (GO:0047497)1.93492646
174establishment of mitochondrion localization, microtubule-mediated (GO:0034643)1.93492646
175keratinocyte development (GO:0003334)1.92980584
176regulation of cell communication by electrical coupling (GO:0010649)1.91895596
177male sex determination (GO:0030238)1.91817807
178negative regulation of activin receptor signaling pathway (GO:0032926)1.90306334
179retinal metabolic process (GO:0042574)1.89851514

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.63023750
2IGF1R_20145208_ChIP-Seq_DFB_Human3.25640256
3GBX2_23144817_ChIP-Seq_PC3_Human2.90110761
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.49166019
5RBPJ_22232070_ChIP-Seq_NCS_Mouse2.28014688
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15011678
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.14471381
8FUS_26573619_Chip-Seq_HEK293_Human2.11189019
9TAF15_26573619_Chip-Seq_HEK293_Human2.08215721
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.97646831
11* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.95327733
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.93269110
13* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85362707
14DROSHA_22980978_ChIP-Seq_HELA_Human1.78928797
15GATA1_22025678_ChIP-Seq_K562_Human1.78598152
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.77678254
17VDR_22108803_ChIP-Seq_LS180_Human1.76483666
18JARID2_20064375_ChIP-Seq_MESCs_Mouse1.75354883
19* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.75045522
20CBX2_27304074_Chip-Seq_ESCs_Mouse1.73554910
21PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71603168
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71228077
23SMAD4_21799915_ChIP-Seq_A2780_Human1.71186722
24* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.69850885
25MTF2_20144788_ChIP-Seq_MESCs_Mouse1.66937615
26FOXM1_26456572_ChIP-Seq_MCF-7_Human1.66820654
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.64618957
28* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.63257147
29ESR1_20079471_ChIP-ChIP_T-47D_Human1.61861191
30NR3C1_23031785_ChIP-Seq_PC12_Mouse1.61205145
31EWS_26573619_Chip-Seq_HEK293_Human1.59361649
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58942186
33* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.58824024
34* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.58824024
35PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.57343935
36ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.55097151
37REST_21632747_ChIP-Seq_MESCs_Mouse1.53988906
38ZNF274_21170338_ChIP-Seq_K562_Hela1.51830303
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51499326
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51431775
41RARB_27405468_Chip-Seq_BRAIN_Mouse1.48683062
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.47096675
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.45847942
44EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.44290197
45P300_19829295_ChIP-Seq_ESCs_Human1.44166674
46JARID2_20075857_ChIP-Seq_MESCs_Mouse1.43812939
47* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.42830777
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.42494489
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41885138
50E2F1_18555785_Chip-Seq_ESCs_Mouse1.38874270
51NR3C1_21868756_ChIP-Seq_MCF10A_Human1.38301675
52P53_22387025_ChIP-Seq_ESCs_Mouse1.35723079
53* AR_25329375_ChIP-Seq_VCAP_Human1.34544239
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.34503969
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34442353
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34041915
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.33911989
58NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.33749865
59RNF2_27304074_Chip-Seq_NSC_Mouse1.33258154
60AR_21572438_ChIP-Seq_LNCaP_Human1.32720869
61TP53_16413492_ChIP-PET_HCT116_Human1.30905891
62RNF2_27304074_Chip-Seq_ESCs_Mouse1.30769419
63* STAT3_23295773_ChIP-Seq_U87_Human1.28902176
64CMYC_18555785_Chip-Seq_ESCs_Mouse1.28894877
65BCAT_22108803_ChIP-Seq_LS180_Human1.28840390
66EZH2_27294783_Chip-Seq_ESCs_Mouse1.28780399
67SUZ12_27294783_Chip-Seq_ESCs_Mouse1.28080018
68TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27752349
69EZH2_27304074_Chip-Seq_ESCs_Mouse1.27027518
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26905484
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26612816
72FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.25371309
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.24837653
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24134016
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24124705
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.22915743
77PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22564965
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20844438
79SUZ12_18555785_Chip-Seq_ESCs_Mouse1.20584218
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20179944
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19517620
82MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18593818
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.17691011
84CBP_20019798_ChIP-Seq_JUKART_Human1.16399685
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16399685
86JUN_21703547_ChIP-Seq_K562_Human1.16077472
87CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15910490
88TAL1_26923725_Chip-Seq_HPCs_Mouse1.15753296
89ARNT_22903824_ChIP-Seq_MCF-7_Human1.14063861
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13728352
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13728352
92SOX2_18555785_Chip-Seq_ESCs_Mouse1.13485434
93LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13460657
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12849096
95IKZF1_21737484_ChIP-ChIP_HCT116_Human1.12747823
96CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12529630
97AR_19668381_ChIP-Seq_PC3_Human1.11101036
98REST_18959480_ChIP-ChIP_MESCs_Mouse1.10583877
99TCF4_23295773_ChIP-Seq_U87_Human1.10525434
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09491650
101BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09400474
102CDX2_22108803_ChIP-Seq_LS180_Human1.08714279
103RUNX_20019798_ChIP-Seq_JUKART_Human1.07787774
104ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07488499
105STAT3_18555785_Chip-Seq_ESCs_Mouse1.06828415
106P300_18555785_Chip-Seq_ESCs_Mouse1.06483287
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06444733
108WT1_19549856_ChIP-ChIP_CCG9911_Human1.05678277
109FLI1_27457419_Chip-Seq_LIVER_Mouse1.04842932
110EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04661989
111RXR_22158963_ChIP-Seq_LIVER_Mouse1.04525453
112VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03078602
113SCL_19346495_ChIP-Seq_HPC-7_Human1.02998086
114RXR_22108803_ChIP-Seq_LS180_Human1.01698505
115TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01497628
116WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01189684
117OCT4_18555785_Chip-Seq_ESCs_Mouse1.01128584
118PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00907999
119ER_23166858_ChIP-Seq_MCF-7_Human1.00903840
120HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00670767
121* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00223060
122CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99884263
123AR_21909140_ChIP-Seq_LNCAP_Human0.99612515
124ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99481635
125NANOG_18555785_Chip-Seq_ESCs_Mouse0.99284445
126ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.99110121
127TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99103884
128AHR_22903824_ChIP-Seq_MCF-7_Human0.98919467
129RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98724538
130LXR_22158963_ChIP-Seq_LIVER_Mouse0.98350217
131CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98120363
132YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97054182
133TP53_18474530_ChIP-ChIP_U2OS_Human0.96779870
134GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96531106
135NRF2_20460467_ChIP-Seq_MEFs_Mouse0.95647283
136NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.95647283
137RUNX2_22187159_ChIP-Seq_PCA_Human0.95375988
138UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94195253
139PRDM14_20953172_ChIP-Seq_ESCs_Human0.93778421
140SMAD4_21741376_ChIP-Seq_HESCs_Human0.93662757
141EP300_21415370_ChIP-Seq_HL-1_Mouse0.93201602
142FLI1_21867929_ChIP-Seq_TH2_Mouse0.92426160
143IRF8_22096565_ChIP-ChIP_GC-B_Human0.92154371
144TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91574545

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.92495899
2MP0004859_abnormal_synaptic_plasticity3.22444541
3MP0009780_abnormal_chondrocyte_physiolo3.12851886
4MP0008057_abnormal_DNA_replication2.78444672
5MP0005645_abnormal_hypothalamus_physiol2.57224921
6MP0003635_abnormal_synaptic_transmissio2.48903843
7MP0003183_abnormal_peptide_metabolism2.41853834
8MP0008877_abnormal_DNA_methylation2.35138361
9MP0002139_abnormal_hepatobiliary_system2.35010725
10MP0005365_abnormal_bile_salt2.28623836
11MP0002063_abnormal_learning/memory/cond2.23367270
12MP0002909_abnormal_adrenal_gland2.21862107
13MP0005646_abnormal_pituitary_gland2.08877846
14MP0002876_abnormal_thyroid_physiology2.08441693
15MP0000566_synostosis2.03348428
16MP0003252_abnormal_bile_duct1.97561744
17MP0003300_gastrointestinal_ulcer1.95711374
18MP0010234_abnormal_vibrissa_follicle1.92580723
19MP0009745_abnormal_behavioral_response1.91688903
20MP0000427_abnormal_hair_cycle1.90138068
21MP0004270_analgesia1.87236029
22MP0000013_abnormal_adipose_tissue1.86635489
23MP0005360_urolithiasis1.83696045
24MP0004130_abnormal_muscle_cell1.82904762
25MP0004885_abnormal_endolymph1.81674406
26MP0003122_maternal_imprinting1.80567424
27MP0002064_seizures1.68695822
28MP0003724_increased_susceptibility_to1.65776958
29MP0002009_preneoplasia1.62035579
30MP0002572_abnormal_emotion/affect_behav1.61978523
31MP0010386_abnormal_urinary_bladder1.60109334
32MP0002557_abnormal_social/conspecific_i1.59196559
33MP0005535_abnormal_body_temperature1.52382384
34MP0001984_abnormal_olfaction1.50126879
35MP0001944_abnormal_pancreas_morphology1.49614919
36MP0010329_abnormal_lipoprotein_level1.48355983
37MP0006054_spinal_hemorrhage1.47400833
38MP0003787_abnormal_imprinting1.46476594
39MP0002166_altered_tumor_susceptibility1.43515555
40MP0003172_abnormal_lysosome_physiology1.43438246
41MP0006276_abnormal_autonomic_nervous1.42339326
42MP0003633_abnormal_nervous_system1.41028029
43MP0005423_abnormal_somatic_nervous1.40944768
44MP0001501_abnormal_sleep_pattern1.39997078
45MP0001486_abnormal_startle_reflex1.37362479
46MP0008569_lethality_at_weaning1.34455115
47MP0002693_abnormal_pancreas_physiology1.34330228
48MP0002078_abnormal_glucose_homeostasis1.31529870
49MP0003283_abnormal_digestive_organ1.30691740
50MP0001968_abnormal_touch/_nociception1.28473728
51MP0002272_abnormal_nervous_system1.26897323
52MP0002928_abnormal_bile_duct1.26117817
53MP0004147_increased_porphyrin_level1.23695723
54MP0003868_abnormal_feces_composition1.22385942
55MP0002877_abnormal_melanocyte_morpholog1.21673153
56MP0010678_abnormal_skin_adnexa1.21411647
57MP0004043_abnormal_pH_regulation1.21254442
58MP0004811_abnormal_neuron_physiology1.20066269
59MP0003880_abnormal_central_pattern1.19083008
60MP0003950_abnormal_plasma_membrane1.18927986
61MP0005551_abnormal_eye_electrophysiolog1.18125709
62MP0005408_hypopigmentation1.17939625
63MP0001879_abnormal_lymphatic_vessel1.16900098
64MP0002067_abnormal_sensory_capabilities1.14996546
65MP0005220_abnormal_exocrine_pancreas1.14858222
66MP0002638_abnormal_pupillary_reflex1.14791826
67MP0008875_abnormal_xenobiotic_pharmacok1.14332190
68MP0000383_abnormal_hair_follicle1.13944494
69MP0005085_abnormal_gallbladder_physiolo1.11987321
70MP0002734_abnormal_mechanical_nocicepti1.11454806
71MP0005174_abnormal_tail_pigmentation1.10090097
72MP0002160_abnormal_reproductive_system1.08014737
73MP0002837_dystrophic_cardiac_calcinosis1.06747265
74MP0010352_gastrointestinal_tract_polyps1.06393424
75MP0002822_catalepsy1.06279457
76MP0005379_endocrine/exocrine_gland_phen1.05200645
77MP0005386_behavior/neurological_phenoty1.05095820
78MP0004924_abnormal_behavior1.05095820
79MP0008961_abnormal_basal_metabolism1.03396312
80MP0003943_abnormal_hepatobiliary_system1.01470572
81MP0002090_abnormal_vision0.99650870
82MP0001177_atelectasis0.98602480
83MP0000462_abnormal_digestive_system0.97632383
84MP0003195_calcinosis0.96525219
85MP0000647_abnormal_sebaceous_gland0.96491367
86MP0005167_abnormal_blood-brain_barrier0.96068448
87MP0001502_abnormal_circadian_rhythm0.94827272
88MP0001666_abnormal_nutrient_absorption0.94145186
89MP0003385_abnormal_body_wall0.93065474
90MP0001299_abnormal_eye_distance/0.92207772
91MP0002118_abnormal_lipid_homeostasis0.92097978
92MP0004134_abnormal_chest_morphology0.91157478
93MP0002733_abnormal_thermal_nociception0.90469893
94MP0002751_abnormal_autonomic_nervous0.89792360
95MP0000778_abnormal_nervous_system0.89345116
96MP0009046_muscle_twitch0.89330081
97MP0005248_abnormal_Harderian_gland0.88772921
98MP0005448_abnormal_energy_balance0.88760604
99MP0002971_abnormal_brown_adipose0.88302066
100MP0005084_abnormal_gallbladder_morpholo0.87812513
101MP0003632_abnormal_nervous_system0.87691558
102MP0005670_abnormal_white_adipose0.87486140
103MP0002184_abnormal_innervation0.87005120
104MP0008789_abnormal_olfactory_epithelium0.84768917
105MP0002098_abnormal_vibrissa_morphology0.84215538
106MP0005584_abnormal_enzyme/coenzyme_acti0.84056197
107MP0000003_abnormal_adipose_tissue0.83404586
108MP0009697_abnormal_copulation0.83141935
109MP0005409_darkened_coat_color0.82706046
110MP0004215_abnormal_myocardial_fiber0.82141023
111MP0002735_abnormal_chemical_nociception0.81775782
112MP0001270_distended_abdomen0.80663128
113MP0003953_abnormal_hormone_level0.80531936
114MP0000631_abnormal_neuroendocrine_gland0.79243911
115MP0005334_abnormal_fat_pad0.78859673
116MP0003631_nervous_system_phenotype0.78748878
117MP0003690_abnormal_glial_cell0.77385534
118MP0000955_abnormal_spinal_cord0.76757753
119MP0003890_abnormal_embryonic-extraembry0.76561963
120MP0000230_abnormal_systemic_arterial0.76524484
121MP0002069_abnormal_eating/drinking_beha0.76126819
122MP0002234_abnormal_pharynx_morphology0.75477369
123MP0003123_paternal_imprinting0.75419287
124MP0001929_abnormal_gametogenesis0.75238868
125MP0002006_tumorigenesis0.75176062
126MP0000639_abnormal_adrenal_gland0.74658478
127MP0005332_abnormal_amino_acid0.74617437
128MP0003121_genomic_imprinting0.73826711
129MP0005187_abnormal_penis_morphology0.73749727
130MP0002882_abnormal_neuron_morphology0.73596339
131MP0009115_abnormal_fat_cell0.73198759
132MP0003075_altered_response_to0.72542043
133MP0003656_abnormal_erythrocyte_physiolo0.72023909
134MP0004084_abnormal_cardiac_muscle0.71530506
135MP0001970_abnormal_pain_threshold0.71061948
136MP0002210_abnormal_sex_determination0.71045593
137MP0005499_abnormal_olfactory_system0.70382961
138MP0005394_taste/olfaction_phenotype0.70382961
139MP0004085_abnormal_heartbeat0.63784444
140MP0003959_abnormal_lean_body0.63679775
141MP0003942_abnormal_urinary_system0.63640721

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic seizures (HP:0002173)3.88309769
2Visual hallucinations (HP:0002367)3.78927057
3Agitation (HP:0000713)3.70903806
4Focal motor seizures (HP:0011153)3.46914931
5Papilledema (HP:0001085)3.42744242
6Papillary thyroid carcinoma (HP:0002895)3.37945333
7Ketoacidosis (HP:0001993)3.36914971
8Volvulus (HP:0002580)3.20399134
9Hypoglycemic coma (HP:0001325)3.18457145
10Septate vagina (HP:0001153)3.13582498
11Symptomatic seizures (HP:0011145)3.07022742
12Hyperinsulinemic hypoglycemia (HP:0000825)2.93171794
13Hyperventilation (HP:0002883)2.90833732
14Truncal ataxia (HP:0002078)2.87599937
15Genetic anticipation (HP:0003743)2.73700493
16Methylmalonic aciduria (HP:0012120)2.71711193
17Ketosis (HP:0001946)2.70485511
18Progressive cerebellar ataxia (HP:0002073)2.66982487
19Oligomenorrhea (HP:0000876)2.62507495
20Focal seizures (HP:0007359)2.62428495
21Thyroid carcinoma (HP:0002890)2.61522442
22Macroorchidism (HP:0000053)2.61382894
23Action tremor (HP:0002345)2.60390392
24Generalized hypopigmentation of hair (HP:0011358)2.55454405
25Fair hair (HP:0002286)2.50373988
26Depression (HP:0000716)2.49202963
27Poor eye contact (HP:0000817)2.46561341
28Abnormality of the common coagulation pathway (HP:0010990)2.42789118
29Termporal pattern (HP:0011008)2.41745986
30Insidious onset (HP:0003587)2.41745986
31Abnormality of the corticospinal tract (HP:0002492)2.39876915
32Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.39068497
33Degeneration of the lateral corticospinal tracts (HP:0002314)2.39068497
34Cubitus valgus (HP:0002967)2.36823087
35Short chin (HP:0000331)2.32794544
36Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.32471035
37Impaired social interactions (HP:0000735)2.29027173
38Abnormal social behavior (HP:0012433)2.29027173
39Abnormal eating behavior (HP:0100738)2.27179598
40Febrile seizures (HP:0002373)2.24145343
41Curly hair (HP:0002212)2.23530824
42Generalized tonic-clonic seizures (HP:0002069)2.23305272
43Metaphyseal dysplasia (HP:0100255)2.22546040
44Polyphagia (HP:0002591)2.22301951
45Renal cortical cysts (HP:0000803)2.22229272
46Anxiety (HP:0000739)2.21857692
47Narrow nasal bridge (HP:0000446)2.19469790
48Blue irides (HP:0000635)2.17561750
49Limb hypertonia (HP:0002509)2.13126216
50Hamartoma of the eye (HP:0010568)2.11980287
51Abnormality of the intrinsic pathway (HP:0010989)2.09458333
52Increased serum pyruvate (HP:0003542)2.09172369
53Myokymia (HP:0002411)2.08817762
54Hemiplegia (HP:0002301)2.07140071
55Amyotrophic lateral sclerosis (HP:0007354)2.02430260
56Proximal tubulopathy (HP:0000114)2.01583067
57Tetraplegia (HP:0002445)2.01212904
58EEG with generalized epileptiform discharges (HP:0011198)1.99897356
59Facial hemangioma (HP:0000329)1.99863940
60Overlapping toe (HP:0001845)1.99718646
61Abnormality of aromatic amino acid family metabolism (HP:0004338)1.99094210
62Epileptiform EEG discharges (HP:0011182)1.98307596
63Pheochromocytoma (HP:0002666)1.97390347
64Excessive salivation (HP:0003781)1.97210513
65Drooling (HP:0002307)1.97210513
66Abnormality of the pancreatic islet cells (HP:0006476)1.96853453
67Abnormality of endocrine pancreas physiology (HP:0012093)1.96853453
68Neuroendocrine neoplasm (HP:0100634)1.95833968
69Deep venous thrombosis (HP:0002625)1.95125936
70Focal dystonia (HP:0004373)1.94314122
71Spinal canal stenosis (HP:0003416)1.94010252
72Abnormality of the renal cortex (HP:0011035)1.93968134
73Hypsarrhythmia (HP:0002521)1.93940095
74Complement deficiency (HP:0004431)1.92904163
75Growth hormone excess (HP:0000845)1.92903318
76Intention tremor (HP:0002080)1.91992674
77Absence seizures (HP:0002121)1.91981860
78Horizontal nystagmus (HP:0000666)1.91336138
79Increased CSF protein (HP:0002922)1.91132250
80Scanning speech (HP:0002168)1.90841406
81Decreased circulating renin level (HP:0003351)1.89176027
82Truncal obesity (HP:0001956)1.88637278
83Torticollis (HP:0000473)1.87936943
84Medial flaring of the eyebrow (HP:0010747)1.87631985
85Hypoalphalipoproteinemia (HP:0003233)1.87041666
86Striae distensae (HP:0001065)1.86792427
87Epileptic encephalopathy (HP:0200134)1.85835957
88Chronic hepatic failure (HP:0100626)1.85664578
89Impaired vibration sensation in the lower limbs (HP:0002166)1.84980579
90Neoplasm of the thyroid gland (HP:0100031)1.84962297
91Hypoventilation (HP:0002791)1.84192921
92Furrowed tongue (HP:0000221)1.83357309
93Gait imbalance (HP:0002141)1.83290942
94Menstrual irregularities (HP:0000858)1.82940189
95Craniofacial dystonia (HP:0012179)1.82773181
96Exotropia (HP:0000577)1.81747285
97Aplasia/Hypoplasia of the tibia (HP:0005772)1.81724734
98Mitral stenosis (HP:0001718)1.80579850
99Menorrhagia (HP:0000132)1.80051630
100Short 1st metacarpal (HP:0010034)1.79636631
101Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.79636631
102Fatigue (HP:0012378)1.79329292
103Conjunctival hamartoma (HP:0100780)1.79216983
104Abnormality of the astrocytes (HP:0100707)1.77928929
105Astrocytoma (HP:0009592)1.77928929
106Late onset (HP:0003584)1.77198141
107Gaze-evoked nystagmus (HP:0000640)1.77125575
108Abnormality of glycolysis (HP:0004366)1.75689525
109Dysdiadochokinesis (HP:0002075)1.75385328
110Psychosis (HP:0000709)1.75372732
111Heterotopia (HP:0002282)1.75330851
112Exocrine pancreatic insufficiency (HP:0001738)1.74260204
113Impaired smooth pursuit (HP:0007772)1.74071147
114Failure to thrive in infancy (HP:0001531)1.73252551
115Glioma (HP:0009733)1.72821840
116Hypoplasia of the thymus (HP:0000778)1.72131161
117Conjugated hyperbilirubinemia (HP:0002908)1.71894533
118Increased circulating renin level (HP:0000848)1.71794511
119Epidermoid cyst (HP:0200040)1.71455167
120Congenital primary aphakia (HP:0007707)1.71424459
121Open mouth (HP:0000194)1.70460136
122Thickened nuchal skin fold (HP:0000474)1.70297478
123Hypothermia (HP:0002045)1.67753736
124Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.67694586
125Atonic seizures (HP:0010819)1.67502054
126Abnormal hair whorl (HP:0010721)1.67153576
127Pancreatic islet-cell hyperplasia (HP:0004510)1.67120108
128Joint hemorrhage (HP:0005261)1.66645452
129Pancreatic cysts (HP:0001737)1.66185371
130Thick eyebrow (HP:0000574)1.66132541
131Dialeptic seizures (HP:0011146)1.64424455
132Prolonged bleeding time (HP:0003010)1.63747638
133Intestinal atresia (HP:0011100)1.63467762
134Sandal gap (HP:0001852)1.63354545
135Intrahepatic cholestasis (HP:0001406)1.63342076
136Abnormality of ocular smooth pursuit (HP:0000617)1.63013530
137Microglossia (HP:0000171)1.61893640
138Prolonged partial thromboplastin time (HP:0003645)1.61800367
139Hamartoma (HP:0010566)1.61558272
140Mucopolysacchariduria (HP:0008155)1.61555656
141Urinary glycosaminoglycan excretion (HP:0003541)1.61555656
142Protruding tongue (HP:0010808)1.61130626
143Progressive inability to walk (HP:0002505)1.61104836
144Abnormality of calcium-phosphate metabolism (HP:0100530)1.60997046
145Widely spaced teeth (HP:0000687)1.60987840
146Hyperglycemia (HP:0003074)1.60888575
147Osteomalacia (HP:0002749)1.60811442
148Congenital malformation of the right heart (HP:0011723)1.60548834
149Double outlet right ventricle (HP:0001719)1.60548834
150Absent speech (HP:0001344)1.60261389
151Short tibia (HP:0005736)1.59986937
152Cystic hygroma (HP:0000476)1.59915234
153Urinary urgency (HP:0000012)1.59553690
154Insulin-resistant diabetes mellitus (HP:0000831)1.59465127
155Hyperlipoproteinemia (HP:0010980)1.58877989
156Nephrogenic diabetes insipidus (HP:0009806)1.58838209
157Pancreatic fibrosis (HP:0100732)1.58492759
158Status epilepticus (HP:0002133)1.58410863
159Gait ataxia (HP:0002066)1.58382525
160Genital tract atresia (HP:0001827)1.55967325
161Hypolipoproteinemia (HP:0010981)1.55817668
162Abnormal biliary tract morphology (HP:0012440)1.54091225
163Deep philtrum (HP:0002002)1.53675680
164Meningioma (HP:0002858)1.53502624
165Intellectual disability, progressive (HP:0006887)1.53443479
166Aplasia/Hypoplasia of the tongue (HP:0010295)1.53219124
167Broad-based gait (HP:0002136)1.52819300
168Sparse lateral eyebrow (HP:0005338)1.52700001
169Inability to walk (HP:0002540)1.52096778
170Gonadotropin excess (HP:0000837)1.51927151

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR3.55641402
2SIK32.61741002
3CCNB12.48905108
4MAP3K122.43034256
5PNCK2.40439520
6ERBB32.33455470
7NTRK32.27283339
8MAP2K42.08709561
9MAP2K72.00356706
10CAMKK21.90457983
11MINK11.85723129
12SGK21.74685739
13FER1.72009606
14MAP3K41.71404237
15WNK31.69530938
16TAOK31.65377293
17SIK21.60655000
18EIF2AK31.57431163
19FGFR31.51651238
20MAP3K61.50486741
21CAMK1G1.47586274
22CDK81.43477950
23PRKCH1.40810227
24CSNK1G11.38503128
25CSNK1A1L1.38258675
26SIK11.35556298
27CSNK1G31.34745604
28JAK11.34114286
29SGK31.29536003
30STK31.27418388
31SGK4941.25912425
32SGK2231.25912425
33FRK1.24324882
34ERN11.24030504
35PIK3CA1.23061574
36PRKD31.21584274
37NEK61.21505521
38PAK31.19518141
39CAMKK11.18546373
40STK38L1.17412271
41RET1.16308046
42ZAP701.16292293
43NTRK21.16233428
44PKN11.15931413
45CLK11.15592546
46RIPK41.15472855
47FGFR21.11773351
48DAPK21.09649940
49ACVR1B1.08343190
50DAPK11.07836368
51TRIB31.07560715
52HIPK21.03678765
53CASK1.03435123
54MAPK131.02916224
55MAP4K21.01784625
56MARK11.01501631
57FES1.00745408
58SCYL21.00223249
59MAP3K90.99183231
60IRAK20.98474799
61KSR10.98156500
62TEC0.97216526
63EIF2AK10.97129669
64LATS10.97001382
65MET0.96914474
66EPHA40.94028829
67WNK10.92562865
68SYK0.91968942
69FLT30.91523725
70LMTK20.91499540
71RIPK10.91149666
72STK390.88136083
73FGFR40.87273320
74CDK50.85458403
75TRIM280.85197325
76MAPK150.84933992
77NEK90.84875513
78EPHA30.83343196
79BRSK20.82983863
80PINK10.81617158
81TXK0.81302934
82PIK3CG0.81024114
83TRPM70.80547636
84CAMK2B0.77750684
85PHKG10.77630858
86PHKG20.77630858
87PDGFRA0.77007769
88TNK20.75226447
89BMPR20.74229942
90RPS6KB10.73567260
91PDK10.72910952
92JAK20.72780089
93PRKCE0.72657417
94PASK0.71270318
95IRAK10.70979724
96PRKCG0.70550527
97KIT0.69724526
98TGFBR20.69549451
99CAMK2D0.69214183
100NTRK10.67278079
101CSNK1E0.66906206
102CAMK1D0.66637534
103CSNK1G20.66283608
104BCR0.65617457
105ITK0.63495668
106KSR20.63049952
107PKN20.62018111
108RPS6KA20.60878740
109SGK10.60486715
110TNIK0.59875572
111RAF10.58483549
112PRKAA10.57981650
113CAMK10.57002023
114PDPK10.56007304
115PLK20.55580362
116YES10.55136210
117FYN0.54191910
118PTK20.54115983
119TGFBR10.53377735
120CSNK1D0.53359816
121CAMK2A0.53063146
122DMPK0.52751645
123ATM0.50869625
124PRKCQ0.50427270
125BRD40.49927952
126CAMK2G0.49257926
127PRKCZ0.49177012
128IGF1R0.49094795
129DYRK1B0.48274235
130MAP3K20.48021240
131BMPR1B0.47416820
132BCKDK0.47246073
133JAK30.47143226
134MST1R0.46208179
135RPS6KA30.45127550
136BTK0.44765300
137UHMK10.43311347
138NEK10.43173883
139DYRK1A0.43052448
140HCK0.42632738
141ERBB20.42576683
142PRKACB0.42438882
143TIE10.42423487
144MAP3K50.42122141
145MAPK100.41417748
146MAP2K10.41115920
147AKT30.41093167
148ICK0.40339869
149CAMK40.40297032
150PRKCI0.39548732
151EIF2AK20.38649989
152MAPK140.36814702
153PAK20.36715566
154DYRK30.36601594
155* CDK10.35849740
156* GSK3B0.35035942

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.64977777
2Insulin secretion_Homo sapiens_hsa049111.98719653
3GABAergic synapse_Homo sapiens_hsa047271.91609849
4Maturity onset diabetes of the young_Homo sapiens_hsa049501.87799566
5Olfactory transduction_Homo sapiens_hsa047401.83185235
6Circadian entrainment_Homo sapiens_hsa047131.80992312
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.73535426
8Nicotine addiction_Homo sapiens_hsa050331.71662553
9Morphine addiction_Homo sapiens_hsa050321.71525962
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.64827030
11Type II diabetes mellitus_Homo sapiens_hsa049301.64007583
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.59872895
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.55179040
14Primary bile acid biosynthesis_Homo sapiens_hsa001201.52061490
15Dopaminergic synapse_Homo sapiens_hsa047281.51833445
16Long-term potentiation_Homo sapiens_hsa047201.46741578
17Amphetamine addiction_Homo sapiens_hsa050311.45952883
18Synaptic vesicle cycle_Homo sapiens_hsa047211.45110053
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.42697105
20Cholinergic synapse_Homo sapiens_hsa047251.40258184
21Glutamatergic synapse_Homo sapiens_hsa047241.39426418
22Vitamin B6 metabolism_Homo sapiens_hsa007501.35285499
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.34290839
24Carbohydrate digestion and absorption_Homo sapiens_hsa049731.32318583
25Basal transcription factors_Homo sapiens_hsa030221.31439560
26Taste transduction_Homo sapiens_hsa047421.30528257
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29999650
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.28962095
29Cocaine addiction_Homo sapiens_hsa050301.27308841
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.27080852
31Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.25694746
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22306842
33Renin secretion_Homo sapiens_hsa049241.20588469
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.17707468
35Steroid biosynthesis_Homo sapiens_hsa001001.12957885
36Retinol metabolism_Homo sapiens_hsa008301.11077706
37Salivary secretion_Homo sapiens_hsa049701.10967978
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10362140
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08053160
40Glucagon signaling pathway_Homo sapiens_hsa049221.07145704
41Gastric acid secretion_Homo sapiens_hsa049711.03929107
42Insulin resistance_Homo sapiens_hsa049311.01383271
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.00499112
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.98668134
45PPAR signaling pathway_Homo sapiens_hsa033200.95747063
46Thyroid hormone synthesis_Homo sapiens_hsa049180.95700289
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94980164
48ErbB signaling pathway_Homo sapiens_hsa040120.90021825
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89927516
50Fatty acid degradation_Homo sapiens_hsa000710.89637110
51Caffeine metabolism_Homo sapiens_hsa002320.87632463
52cAMP signaling pathway_Homo sapiens_hsa040240.86598943
53Sphingolipid metabolism_Homo sapiens_hsa006000.86560191
54Propanoate metabolism_Homo sapiens_hsa006400.85770970
55Sulfur metabolism_Homo sapiens_hsa009200.84922540
56Serotonergic synapse_Homo sapiens_hsa047260.84861837
57mTOR signaling pathway_Homo sapiens_hsa041500.84228192
58Bile secretion_Homo sapiens_hsa049760.84205498
59Glioma_Homo sapiens_hsa052140.83387889
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82619677
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81925854
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81139813
63Fatty acid metabolism_Homo sapiens_hsa012120.80262159
64Calcium signaling pathway_Homo sapiens_hsa040200.79862525
65Arginine biosynthesis_Homo sapiens_hsa002200.78561910
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78265470
67ABC transporters_Homo sapiens_hsa020100.78252940
68Butanoate metabolism_Homo sapiens_hsa006500.77333428
69beta-Alanine metabolism_Homo sapiens_hsa004100.75297952
70Pancreatic secretion_Homo sapiens_hsa049720.74933504
71Oocyte meiosis_Homo sapiens_hsa041140.74315907
72Oxytocin signaling pathway_Homo sapiens_hsa049210.71324274
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.70833299
74N-Glycan biosynthesis_Homo sapiens_hsa005100.69667066
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69263761
76Complement and coagulation cascades_Homo sapiens_hsa046100.68981382
77Prolactin signaling pathway_Homo sapiens_hsa049170.68967860
78Chemical carcinogenesis_Homo sapiens_hsa052040.68860445
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.68855991
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67928508
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67042426
82Estrogen signaling pathway_Homo sapiens_hsa049150.66830768
83Linoleic acid metabolism_Homo sapiens_hsa005910.66296675
84Circadian rhythm_Homo sapiens_hsa047100.66251758
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65311924
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64885202
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64489486
88Peroxisome_Homo sapiens_hsa041460.63904414
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63445900
90Non-homologous end-joining_Homo sapiens_hsa034500.63406807
91Dorso-ventral axis formation_Homo sapiens_hsa043200.63290158
92Insulin signaling pathway_Homo sapiens_hsa049100.62778783
93Protein export_Homo sapiens_hsa030600.62538476
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62137291
95Tryptophan metabolism_Homo sapiens_hsa003800.61843628
96Renal cell carcinoma_Homo sapiens_hsa052110.61681147
97Inositol phosphate metabolism_Homo sapiens_hsa005620.60828690
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60794912
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60421944
100Melanoma_Homo sapiens_hsa052180.60342800
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59292117
102Vibrio cholerae infection_Homo sapiens_hsa051100.59243954
103AMPK signaling pathway_Homo sapiens_hsa041520.59110600
104Mineral absorption_Homo sapiens_hsa049780.59009113
105Choline metabolism in cancer_Homo sapiens_hsa052310.58826200
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58605620
107GnRH signaling pathway_Homo sapiens_hsa049120.58306726
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57794113
109Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57168258
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56173103
111Non-small cell lung cancer_Homo sapiens_hsa052230.54305488
112Fatty acid biosynthesis_Homo sapiens_hsa000610.53734643
113TGF-beta signaling pathway_Homo sapiens_hsa043500.53359665
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53280602
115Starch and sucrose metabolism_Homo sapiens_hsa005000.52511506
116Carbon metabolism_Homo sapiens_hsa012000.52428169
117Long-term depression_Homo sapiens_hsa047300.52297105
118Folate biosynthesis_Homo sapiens_hsa007900.51515498
119Nucleotide excision repair_Homo sapiens_hsa034200.51418783
120Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50847787
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.50488551
122Pyruvate metabolism_Homo sapiens_hsa006200.50353157
123Type I diabetes mellitus_Homo sapiens_hsa049400.49571708
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49032480
125Lysine degradation_Homo sapiens_hsa003100.48951979
126Platelet activation_Homo sapiens_hsa046110.48950055
127Melanogenesis_Homo sapiens_hsa049160.47456881
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46671779
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45938760
130Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45840757
131Ovarian steroidogenesis_Homo sapiens_hsa049130.45594754
132Glycerolipid metabolism_Homo sapiens_hsa005610.44760721
133Collecting duct acid secretion_Homo sapiens_hsa049660.40615667
134Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39930448
135B cell receptor signaling pathway_Homo sapiens_hsa046620.39743744

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