ZGPAT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.72411278
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.72411278
3positive thymic T cell selection (GO:0045059)4.79606925
4negative thymic T cell selection (GO:0045060)4.72757686
5negative T cell selection (GO:0043383)4.71771505
6regulation of gamma-delta T cell differentiation (GO:0045586)4.71416235
7sodium ion export (GO:0071436)4.68138293
8positive regulation of gamma-delta T cell activation (GO:0046645)4.67586387
9synaptic vesicle maturation (GO:0016188)4.58136765
10locomotory exploration behavior (GO:0035641)4.57644440
11thymic T cell selection (GO:0045061)4.38596923
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.34111546
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.34111546
14regulation of ARF protein signal transduction (GO:0032012)4.22049746
15positive T cell selection (GO:0043368)4.11286332
16regulation of gamma-delta T cell activation (GO:0046643)4.00174517
17T cell selection (GO:0045058)3.97946839
18positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.94075781
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.85679230
20antigen processing and presentation of endogenous antigen (GO:0019883)3.75578447
21response to peptidoglycan (GO:0032494)3.74724638
22NIK/NF-kappaB signaling (GO:0038061)3.71822930
23positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.70410968
24neutrophil activation involved in immune response (GO:0002283)3.64128240
25regulation of short-term neuronal synaptic plasticity (GO:0048172)3.61315799
26negative regulation of interleukin-12 production (GO:0032695)3.58095176
27response to interleukin-15 (GO:0070672)3.55888220
28cellular potassium ion homeostasis (GO:0030007)3.55470385
29layer formation in cerebral cortex (GO:0021819)3.51566997
30detection of bacterium (GO:0016045)3.47998539
31positive regulation of histone deacetylation (GO:0031065)3.45727305
32positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.43617621
33negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.42731889
34detection of other organism (GO:0098543)3.42223050
35immunoglobulin mediated immune response (GO:0016064)3.40077378
36modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.38801719
37positive regulation by organism of defense response of other organism involved in symbiotic interact3.38801719
38modulation by symbiont of host immune response (GO:0052553)3.38801719
39positive regulation by symbiont of host defense response (GO:0052509)3.38801719
40modulation by symbiont of host defense response (GO:0052031)3.38801719
41modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.38801719
42macrophage activation involved in immune response (GO:0002281)3.31175076
43leukocyte aggregation (GO:0070486)3.26863578
44response to muramyl dipeptide (GO:0032495)3.23835870
45activation of protein kinase A activity (GO:0034199)3.23321658
46regulation of synapse structural plasticity (GO:0051823)3.21364593
47cellular response to type I interferon (GO:0071357)3.21019336
48type I interferon signaling pathway (GO:0060337)3.21019336
49response to type I interferon (GO:0034340)3.19832704
50potassium ion import (GO:0010107)3.17539926
51regulation of ARF GTPase activity (GO:0032312)3.17198710
52regulation of isotype switching to IgG isotypes (GO:0048302)3.16473199
53peptidyl-lysine dimethylation (GO:0018027)3.15575102
54cell communication by electrical coupling (GO:0010644)3.15268565
55positive regulation of Rap GTPase activity (GO:0032854)3.12822704
56lipopolysaccharide-mediated signaling pathway (GO:0031663)3.11933579
57cytoskeletal anchoring at plasma membrane (GO:0007016)3.09756289
58establishment of nucleus localization (GO:0040023)3.05895468
59negative regulation of cytokine production involved in immune response (GO:0002719)3.03792269
60synaptic vesicle docking involved in exocytosis (GO:0016081)3.00012625
61positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.98542360
62signal complex assembly (GO:0007172)2.96591278
63negative regulation of type 2 immune response (GO:0002829)2.96571118
64cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.95807917
65alanine transport (GO:0032328)2.95145496
66negative regulation of innate immune response (GO:0045824)2.92360466
67positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.92122198
68cellular response to interleukin-15 (GO:0071350)2.91644306
69regulation of dendritic cell antigen processing and presentation (GO:0002604)2.90840595
70negative regulation of cell size (GO:0045792)2.90436617
71negative regulation of leukocyte mediated immunity (GO:0002704)2.90420813
72negative regulation of erythrocyte differentiation (GO:0045647)2.89375260
73stress granule assembly (GO:0034063)2.88734077
74regulation of defense response to virus by virus (GO:0050690)2.88418124
75regulation of interferon-beta biosynthetic process (GO:0045357)2.87236619
76germinal center formation (GO:0002467)2.86058795
77detection of external biotic stimulus (GO:0098581)2.85431278
78regulation of T-helper 2 cell differentiation (GO:0045628)2.84255989
79T cell receptor signaling pathway (GO:0050852)2.82635087
80positive regulation of Cdc42 GTPase activity (GO:0043089)2.81380052
81positive regulation of lipoprotein lipase activity (GO:0051006)2.77930626
82positive regulation of triglyceride lipase activity (GO:0061365)2.77930626
83positive regulation of synapse maturation (GO:0090129)2.77393174
84regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.77222416
85cerebellar Purkinje cell differentiation (GO:0021702)2.76857841
86regulation of myeloid leukocyte mediated immunity (GO:0002886)2.76284123
87regulation of superoxide anion generation (GO:0032928)2.76202517
88myeloid dendritic cell differentiation (GO:0043011)2.75635639
89positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.75384568
90G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.74057750
91exploration behavior (GO:0035640)2.73970191
92positive regulation of isotype switching (GO:0045830)2.73818775
93lymphocyte migration (GO:0072676)2.73645069
94regulation of interleukin-12 biosynthetic process (GO:0045075)2.73604055
95positive regulation of antigen processing and presentation (GO:0002579)2.72914737
96negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.71155137
97regulation of leukocyte degranulation (GO:0043300)2.70797173
98negative regulation of myeloid cell apoptotic process (GO:0033033)2.70202560
99positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.70034082
100positive regulation of tolerance induction (GO:0002645)2.69970732
101regulation of T cell tolerance induction (GO:0002664)2.69582346
102neurotransmitter secretion (GO:0007269)2.68704438
103negative regulation of lymphocyte mediated immunity (GO:0002707)2.67847328
104dicarboxylic acid biosynthetic process (GO:0043650)2.67514646
105response to protozoan (GO:0001562)2.67160793
106natural killer cell differentiation (GO:0001779)2.67077900
107pre-miRNA processing (GO:0031054)2.66619932
108regulation of Rap GTPase activity (GO:0032317)2.66213003
109defense response to protozoan (GO:0042832)2.65973475
110regulation of T-helper 1 cell differentiation (GO:0045625)2.65563055
111cellular sodium ion homeostasis (GO:0006883)2.64982736
112myeloid cell activation involved in immune response (GO:0002275)2.64473822
113B cell mediated immunity (GO:0019724)2.63273648
114granulocyte activation (GO:0036230)2.62795013
115regulation of necroptotic process (GO:0060544)2.62623658
116myeloid dendritic cell activation (GO:0001773)2.62608744
117response to pheromone (GO:0019236)2.62397232
118neuromuscular process controlling balance (GO:0050885)2.60104132
119regulation of antigen processing and presentation (GO:0002577)2.59857527
120Arp2/3 complex-mediated actin nucleation (GO:0034314)2.57613305
121interferon-gamma-mediated signaling pathway (GO:0060333)2.57139117
122detection of biotic stimulus (GO:0009595)2.57135245
123activation of JUN kinase activity (GO:0007257)2.54717619
124positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.54501755
125regulation of type 2 immune response (GO:0002828)2.54376142
126regulation of cytokine secretion involved in immune response (GO:0002739)2.54308857
127T cell costimulation (GO:0031295)2.54187769
128cerebellar Purkinje cell layer development (GO:0021680)2.52677381
129neutrophil activation (GO:0042119)2.52472688
130pinocytosis (GO:0006907)2.52396295
131regulation of mast cell degranulation (GO:0043304)2.51724455
132gamma-aminobutyric acid transport (GO:0015812)2.51664452
133B cell receptor signaling pathway (GO:0050853)2.51614992
134prepulse inhibition (GO:0060134)2.51458909
135negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.51283716
136T cell migration (GO:0072678)2.49409329
137positive regulation of B cell differentiation (GO:0045579)2.49156382
138regulation of necrotic cell death (GO:0010939)2.48752972
139lymphocyte costimulation (GO:0031294)2.48441867
140positive regulation of RNA splicing (GO:0033120)2.47658714
141synaptic vesicle exocytosis (GO:0016079)2.47162375
142regulation of cholesterol homeostasis (GO:2000188)2.46806547
143respiratory burst (GO:0045730)2.46621413
144negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.46185624
145regulation of B cell receptor signaling pathway (GO:0050855)2.45906784
146antigen receptor-mediated signaling pathway (GO:0050851)2.45831310
147vocalization behavior (GO:0071625)2.44510734
148cellular extravasation (GO:0045123)2.44227230
149negative regulation of T-helper cell differentiation (GO:0045623)2.43626773
150negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.43626773
151interferon-gamma production (GO:0032609)2.41951519
152antigen processing and presentation via MHC class Ib (GO:0002475)2.41933162
153lymphocyte chemotaxis (GO:0048247)2.40454325
154dendrite morphogenesis (GO:0048813)2.39902991
155regulation of synaptic vesicle exocytosis (GO:2000300)2.39159627
156positive regulation of immunoglobulin mediated immune response (GO:0002891)2.38598703
157positive regulation of B cell mediated immunity (GO:0002714)2.38598703
158glutamate secretion (GO:0014047)2.38431991
159negative regulation of protein oligomerization (GO:0032460)2.38378002
160regulation of glutamate receptor signaling pathway (GO:1900449)2.38202515
161response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.37404988
162response to host immune response (GO:0052572)2.37404988
163regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.36665943
164regulation of natural killer cell mediated immunity (GO:0002715)2.36665943
165dendritic cell chemotaxis (GO:0002407)2.36601783
166receptor catabolic process (GO:0032801)2.36572664
167JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.36044935
168negative regulation of fibrinolysis (GO:0051918)2.35970545
169histone H4-K16 acetylation (GO:0043984)2.34570427
170glial cell proliferation (GO:0014009)2.33678462
171regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.30422115
172Golgi transport vesicle coating (GO:0048200)2.27748115
173COPI coating of Golgi vesicle (GO:0048205)2.27748115
174mannose metabolic process (GO:0006013)2.27264283
175regulation of type I interferon-mediated signaling pathway (GO:0060338)2.26513040
176long-term memory (GO:0007616)2.25611705
177regulation of clathrin-mediated endocytosis (GO:2000369)2.25181855
178positive regulation of protein deacetylation (GO:0090312)2.24716244
179adaptation of signaling pathway (GO:0023058)2.23987863
180clathrin coat assembly (GO:0048268)2.22882863

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human4.08111400
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.61537293
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.02900556
4KDM2B_26808549_Chip-Seq_DND41_Human2.99758448
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.97361639
6KDM2B_26808549_Chip-Seq_SUP-B15_Human2.88938403
7KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.81259862
8TCF7_22412390_ChIP-Seq_EML_Mouse2.73026511
9VDR_21846776_ChIP-Seq_THP-1_Human2.69406995
10KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.61591499
11LXR_22292898_ChIP-Seq_THP-1_Human2.45845480
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.42775959
13E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.37860792
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.29220630
15MAF_26560356_Chip-Seq_TH1_Human2.27161469
16UTX_26944678_Chip-Seq_JUKART_Human2.26705748
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.20353570
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.19347814
19KDM2B_26808549_Chip-Seq_JURKAT_Human2.14937691
20DNAJC2_21179169_ChIP-ChIP_NT2_Human2.06765519
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.02089942
22IRF8_21731497_ChIP-ChIP_J774_Mouse1.99489658
23GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.99319814
24RUNX_20019798_ChIP-Seq_JUKART_Human1.98992245
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.98123884
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.98070973
27ZFP281_18757296_ChIP-ChIP_E14_Mouse1.95739553
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.95574496
29* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.94391141
30KDM2B_26808549_Chip-Seq_K562_Human1.92849276
31SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90677971
32* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.89852577
33ELK3_25401928_ChIP-Seq_HUVEC_Human1.88824710
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.87217097
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.86541039
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.84666835
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.82368685
38DROSHA_22980978_ChIP-Seq_HELA_Human1.81488399
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.80279203
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.79193326
41DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.78686339
42ZFP281_27345836_Chip-Seq_ESCs_Mouse1.70703536
43TP63_17297297_ChIP-ChIP_HaCaT_Human1.69258551
44CIITA_25753668_ChIP-Seq_RAJI_Human1.67211252
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65090847
46EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.58111311
47P68_20966046_ChIP-Seq_HELA_Human1.57275820
48* SPI1_23547873_ChIP-Seq_NB4_Human1.56359290
49* SPI1_23127762_ChIP-Seq_K562_Human1.55866385
50MAF_26560356_Chip-Seq_TH2_Human1.55391662
51IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.55277564
52MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.54814997
53MYB_26560356_Chip-Seq_TH2_Human1.53811602
54WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.53371594
55IRF8_27001747_Chip-Seq_BMDM_Mouse1.53031991
56MYB_26560356_Chip-Seq_TH1_Human1.51825294
57VDR_24763502_ChIP-Seq_THP-1_Human1.51807629
58ZNF263_19887448_ChIP-Seq_K562_Human1.50535515
59* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.50135134
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.49936104
61GATA1_19941826_ChIP-Seq_K562_Human1.49252542
62MYB_21317192_ChIP-Seq_ERMYB_Mouse1.48133893
63RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.47640838
64CREB1_26743006_Chip-Seq_LNCaP_Human1.47357372
65* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.46873801
66TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.46870567
67SCL_19346495_ChIP-Seq_HPC-7_Human1.46645377
68* SMC4_20622854_ChIP-Seq_HELA_Human1.45747459
69TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.45135676
70TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44843966
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.44393109
72GATA1_22025678_ChIP-Seq_K562_Human1.41368225
73PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.41272224
74EZH2_22144423_ChIP-Seq_EOC_Human1.39848491
75VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39030793
76CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.38047758
77CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.37377771
78RACK7_27058665_Chip-Seq_MCF-7_Human1.34921096
79ELF1_20517297_ChIP-Seq_JURKAT_Human1.33162504
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.33034296
81P300_27058665_Chip-Seq_ZR-75-30cells_Human1.32245729
82CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31614363
83IRF8_22096565_ChIP-ChIP_GC-B_Human1.28547948
84STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28470243
85RXR_22158963_ChIP-Seq_LIVER_Mouse1.28321259
86TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27322127
87PU.1_20513432_ChIP-Seq_Bcells_Mouse1.27102242
88CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27027315
89SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25428909
90GATA3_27048872_Chip-Seq_THYMUS_Human1.24304474
91SA1_27219007_Chip-Seq_ERYTHROID_Human1.22903483
92PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21706630
93ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.21065427
94CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.20742482
95* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.20635365
96SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20405621
97CTCF_27219007_Chip-Seq_ERYTHROID_Human1.19795675
98REST_18959480_ChIP-ChIP_MESCs_Mouse1.18909642
99FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.18305574
100* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16461380
101RUNX1_22412390_ChIP-Seq_EML_Mouse1.16170802
102SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15118450
103BCOR_27268052_Chip-Seq_Bcells_Human1.15012387
104CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14329229
105STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.13770538
106TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13020194
107NCOR1_26117541_ChIP-Seq_K562_Human1.12938932
108TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12661498
109GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11970715
110CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11848470
111CTCF_21964334_ChIP-Seq_BJAB-B_Human1.11590458
112LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.11464717
113* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11427913
114CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11271823
115KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11210331
116BCL6_27268052_Chip-Seq_Bcells_Human1.10823411
117UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10013122
118BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08324660
119RUNX1_27514584_Chip-Seq_MCF-7_Human1.08190290
120KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08123016
121CTCF_26484167_Chip-Seq_Bcells_Mouse1.07923237
122FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.07731951
123CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.06471021
124CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06415887
125GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06257867
126ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04762139
127ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04376703
128CLOCK_20551151_ChIP-Seq_293T_Human1.03703314
129CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01772222
130IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00964742
131PHF8_20622854_ChIP-Seq_HELA_Human1.00669221
132SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.00334662
133NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.99075621
134PPARA_22158963_ChIP-Seq_LIVER_Mouse0.98673009
135ERG_21242973_ChIP-ChIP_JURKAT_Human0.97018538
136NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.96607498
137SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93985114
138SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.93005479
139REST_21632747_ChIP-Seq_MESCs_Mouse0.92497597
140CTCF_27219007_Chip-Seq_Bcells_Human0.91395859
141GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90325447
142SA1_27219007_Chip-Seq_Bcells_Human0.90099020
143SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.90030430
144TET1_21451524_ChIP-Seq_MESCs_Mouse0.88960669

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.03724578
2MP0003436_decreased_susceptibility_to3.78464353
3MP0008961_abnormal_basal_metabolism3.50180009
4MP0003763_abnormal_thymus_physiology3.32145991
5MP0005058_abnormal_lysosome_morphology3.21081937
6MP0006082_CNS_inflammation2.84684146
7MP0003300_gastrointestinal_ulcer2.70649651
8MP0003191_abnormal_cellular_cholesterol2.68772656
9MP0005451_abnormal_body_composition2.65453640
10MP0009785_altered_susceptibility_to2.58101446
11MP0003724_increased_susceptibility_to2.56445979
12MP0005025_abnormal_response_to2.51927490
13MP0002419_abnormal_innate_immunity2.50699362
14MP0002822_catalepsy2.50442724
15MP0000685_abnormal_immune_system2.48161977
16MP0002909_abnormal_adrenal_gland2.45012553
17MP0003635_abnormal_synaptic_transmissio2.38338054
18MP0002148_abnormal_hypersensitivity_rea2.34129877
19MP0003303_peritoneal_inflammation2.26735243
20MP0009333_abnormal_splenocyte_physiolog2.21900487
21MP0000569_abnormal_digit_pigmentation2.10956465
22MP0008260_abnormal_autophagy2.09344556
23MP0008569_lethality_at_weaning2.05094349
24MP0003329_amyloid_beta_deposits2.00689330
25MP0000858_altered_metastatic_potential1.97655534
26MP0002132_abnormal_respiratory_system1.94428183
27MP0003806_abnormal_nucleotide_metabolis1.91697226
28MP0003172_abnormal_lysosome_physiology1.85102374
29MP0002405_respiratory_system_inflammati1.83572827
30MP0002166_altered_tumor_susceptibility1.83231521
31MP0005671_abnormal_response_to1.80451869
32MP0004130_abnormal_muscle_cell1.80425057
33MP0001533_abnormal_skeleton_physiology1.79965660
34MP0003866_abnormal_defecation1.78974386
35MP0010234_abnormal_vibrissa_follicle1.75185811
36MP0005423_abnormal_somatic_nervous1.74209635
37MP0000013_abnormal_adipose_tissue1.70845830
38MP0001873_stomach_inflammation1.70132756
39MP0001845_abnormal_inflammatory_respons1.64353028
40MP0004510_myositis1.64346803
41MP0000703_abnormal_thymus_morphology1.63257850
42MP0002398_abnormal_bone_marrow1.63046075
43MP0005076_abnormal_cell_differentiation1.61452133
44MP0008469_abnormal_protein_level1.57902675
45MP0009745_abnormal_behavioral_response1.55504189
46MP0002063_abnormal_learning/memory/cond1.55247594
47MP0001800_abnormal_humoral_immune1.54726988
48MP0003705_abnormal_hypodermis_morpholog1.48196487
49MP0009764_decreased_sensitivity_to1.48150728
50MP0000604_amyloidosis1.46940260
51MP0002064_seizures1.45893937
52MP0002396_abnormal_hematopoietic_system1.45160341
53MP0009780_abnormal_chondrocyte_physiolo1.43610560
54MP0004811_abnormal_neuron_physiology1.40580757
55MP0005387_immune_system_phenotype1.36754313
56MP0001790_abnormal_immune_system1.36754313
57MP0001853_heart_inflammation1.34286407
58MP0003183_abnormal_peptide_metabolism1.28323913
59MP0002420_abnormal_adaptive_immunity1.26872261
60MP0002722_abnormal_immune_system1.24848656
61MP0001819_abnormal_immune_cell1.23110805
62MP0009278_abnormal_bone_marrow1.22793299
63MP0000716_abnormal_immune_system1.22662950
64MP0002998_abnormal_bone_remodeling1.22024297
65MP0004947_skin_inflammation1.20212365
66MP0003453_abnormal_keratinocyte_physiol1.18920622
67MP0003283_abnormal_digestive_organ1.18528593
68MP0005360_urolithiasis1.17882434
69MP0009046_muscle_twitch1.17231279
70MP0000465_gastrointestinal_hemorrhage1.16714922
71MP0000003_abnormal_adipose_tissue1.16682006
72MP0003045_fibrosis1.16314337
73MP0004270_analgesia1.16043880
74MP0000689_abnormal_spleen_morphology1.14652314
75MP0002089_abnormal_postnatal_growth/wei1.14257868
76MP0002723_abnormal_immune_serum1.14240055
77MP0005310_abnormal_salivary_gland1.10765704
78MP0000343_altered_response_to1.09773631
79MP0004885_abnormal_endolymph1.08983505
80MP0000751_myopathy1.08157898
81MP0004808_abnormal_hematopoietic_stem1.06811396
82MP0005166_decreased_susceptibility_to1.06689339
83MP0003448_altered_tumor_morphology1.06121855
84MP0005464_abnormal_platelet_physiology1.05125580
85MP0002006_tumorigenesis1.02903870
86MP0009840_abnormal_foam_cell1.02367233
87MP0002429_abnormal_blood_cell1.02244520
88MP0001849_ear_inflammation1.02194389
89MP0000747_muscle_weakness1.00505471
90MP0004233_abnormal_muscle_weight1.00365927
91MP0002452_abnormal_antigen_presenting0.99042425
92MP0002572_abnormal_emotion/affect_behav0.97789221
93MP0005365_abnormal_bile_salt0.97490970
94MP0008874_decreased_physiological_sensi0.97100865
95MP0003828_pulmonary_edema0.96836533
96MP0001835_abnormal_antigen_presentation0.96662469
97MP0003633_abnormal_nervous_system0.95565259
98MP0004381_abnormal_hair_follicle0.95054017
99MP0005375_adipose_tissue_phenotype0.94926718
100MP0004185_abnormal_adipocyte_glucose0.94789752
101MP0003690_abnormal_glial_cell0.94474780
102MP0003879_abnormal_hair_cell0.93197682
103MP0003075_altered_response_to0.92964243
104MP0002933_joint_inflammation0.92148759
105MP0003656_abnormal_erythrocyte_physiolo0.91227160
106MP0005000_abnormal_immune_tolerance0.89578322
107MP0004883_abnormal_blood_vessel0.88716059
108MP0009763_increased_sensitivity_to0.88329268
109MP0001663_abnormal_digestive_system0.87232740
110MP0000609_abnormal_liver_physiology0.86349822
111MP0010155_abnormal_intestine_physiology0.86075452
112MP0005164_abnormal_response_to0.84904583
113MP0000955_abnormal_spinal_cord0.84409970
114MP0000490_abnormal_crypts_of0.84315454
115MP0004858_abnormal_nervous_system0.83603863
116MP0005390_skeleton_phenotype0.83416873
117MP0005319_abnormal_enzyme/_coenzyme0.83210928
118MP0003252_abnormal_bile_duct0.82889925
119MP0001502_abnormal_circadian_rhythm0.80316132
120MP0005083_abnormal_biliary_tract0.79729078
121MP0003091_abnormal_cell_migration0.79333249
122MP0001545_abnormal_hematopoietic_system0.77722546
123MP0005397_hematopoietic_system_phenotyp0.77722546
124MP0002269_muscular_atrophy0.77320756
125MP0005023_abnormal_wound_healing0.77302874
126MP0001851_eye_inflammation0.77026097
127MP0002877_abnormal_melanocyte_morpholog0.76757584
128MP0008770_decreased_survivor_rate0.76621845
129MP0002653_abnormal_ependyma_morphology0.75978920
130MP0010329_abnormal_lipoprotein_level0.75026207
131MP0002254_reproductive_system_inflammat0.74804439
132MP0001348_abnormal_lacrimal_gland0.74735637
133MP0002139_abnormal_hepatobiliary_system0.74300760
134MP0002019_abnormal_tumor_incidence0.73986201
135MP0005666_abnormal_adipose_tissue0.73727532
136MP0003787_abnormal_imprinting0.72827476
137MP0002078_abnormal_glucose_homeostasis0.71757268
138MP0001501_abnormal_sleep_pattern0.71693285
139MP0008872_abnormal_physiological_respon0.71024930
140MP0000249_abnormal_blood_vessel0.71023544
141MP0002069_abnormal_eating/drinking_beha0.69290310
142MP0002138_abnormal_hepatobiliary_system0.69223932
143MP0005386_behavior/neurological_phenoty0.68762664
144MP0004924_abnormal_behavior0.68762664
145MP0002272_abnormal_nervous_system0.68477423
146MP0010352_gastrointestinal_tract_polyps0.67614870
147MP0001944_abnormal_pancreas_morphology0.66983385
148MP0008875_abnormal_xenobiotic_pharmacok0.64949971
149MP0003566_abnormal_cell_adhesion0.64287107
150MP0003795_abnormal_bone_structure0.61322775
151MP0004264_abnormal_extraembryonic_tissu0.60975410

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.41946941
2Abnormality of macrophages (HP:0004311)4.28553118
3Myositis (HP:0100614)4.19431265
4Recurrent abscess formation (HP:0002722)3.99210346
5Recurrent bacterial skin infections (HP:0005406)3.89271199
6Hyperacusis (HP:0010780)3.80320655
7Abnormality of liposaccharide metabolism (HP:0010968)3.77427100
8Abnormality of glycosphingolipid metabolism (HP:0004343)3.77427100
9Abnormality of glycolipid metabolism (HP:0010969)3.77427100
10Mediastinal lymphadenopathy (HP:0100721)3.70699783
11Systemic lupus erythematosus (HP:0002725)3.62433158
12Recurrent gram-negative bacterial infections (HP:0005420)3.57194946
13Abnormality of the lower motor neuron (HP:0002366)3.40588956
14Increased serum ferritin (HP:0003281)3.33650009
15Orchitis (HP:0100796)3.32255887
16Hemiplegia (HP:0002301)3.27214186
17Insomnia (HP:0100785)3.20899999
18Stomatitis (HP:0010280)3.20271617
19Abnormality of the fingertips (HP:0001211)3.20082659
20Visual hallucinations (HP:0002367)3.14255797
21Obstructive lung disease (HP:0006536)3.13934508
22Chronic obstructive pulmonary disease (HP:0006510)3.13934508
23Deep venous thrombosis (HP:0002625)3.08925128
24Cerebral aneurysm (HP:0004944)3.03724460
25Dysostosis multiplex (HP:0000943)3.02847717
26Increased cerebral lipofuscin (HP:0011813)2.99957446
27Optic neuritis (HP:0100653)2.99106346
28Retrobulbar optic neuritis (HP:0100654)2.99106346
29Abnormality of monocarboxylic acid metabolism (HP:0010996)2.95552163
30Macroorchidism (HP:0000053)2.89833511
31Myokymia (HP:0002411)2.89357344
32Pustule (HP:0200039)2.81723402
33Meningitis (HP:0001287)2.79246862
34Elfin facies (HP:0004428)2.75841982
35Loss of speech (HP:0002371)2.75019666
36Pointed chin (HP:0000307)2.73474503
37Purpura (HP:0000979)2.72561193
38T lymphocytopenia (HP:0005403)2.71761309
39Abnormal social behavior (HP:0012433)2.70907344
40Impaired social interactions (HP:0000735)2.70907344
41Vacuolated lymphocytes (HP:0001922)2.68873292
42Ankle clonus (HP:0011448)2.66833692
43Gingivitis (HP:0000230)2.62351446
44Increased IgM level (HP:0003496)2.62190371
45Abnormality of iron homeostasis (HP:0011031)2.61926986
46Increased IgE level (HP:0003212)2.61783241
47Abnormality of complement system (HP:0005339)2.60852425
48Complement deficiency (HP:0004431)2.56905103
49Neoplasm of the heart (HP:0100544)2.55863710
50Urinary urgency (HP:0000012)2.54252838
51Increased neuronal autofluorescent lipopigment (HP:0002074)2.52961024
52Depression (HP:0000716)2.52314227
53Dysmetric saccades (HP:0000641)2.50481704
54Interstitial pulmonary disease (HP:0006530)2.50466830
55Recurrent skin infections (HP:0001581)2.46921907
56Pulmonary infiltrates (HP:0002113)2.46570138
57Cellulitis (HP:0100658)2.45596311
58Abnormality of T cell number (HP:0011839)2.44695445
59Amyloidosis (HP:0011034)2.44539897
60Abnormal delayed hypersensitivity skin test (HP:0002963)2.44184119
61Abnormality of polysaccharide metabolism (HP:0011012)2.43381819
62Abnormality of glycosaminoglycan metabolism (HP:0004371)2.43381819
63Abnormality of mucopolysaccharide metabolism (HP:0011020)2.43381819
64Ragged-red muscle fibers (HP:0003200)2.40864672
65Panhypogammaglobulinemia (HP:0003139)2.39982031
66Heterotopia (HP:0002282)2.39045677
67Upper limb amyotrophy (HP:0009129)2.38146718
68Distal upper limb amyotrophy (HP:0007149)2.38146718
69Gastrointestinal inflammation (HP:0004386)2.37927257
70Urticaria (HP:0001025)2.36278144
71Focal seizures (HP:0007359)2.34257958
72Abnormality of oral frenula (HP:0000190)2.34198306
73Hemorrhage of the eye (HP:0011885)2.34149751
74Resting tremor (HP:0002322)2.32575681
75Amyotrophic lateral sclerosis (HP:0007354)2.31797356
76Hypertensive crisis (HP:0100735)2.30278030
77Impaired vibration sensation in the lower limbs (HP:0002166)2.30040215
78Fatigue (HP:0012378)2.30002622
79Vasculitis (HP:0002633)2.29014830
80Colitis (HP:0002583)2.28577916
81Renovascular hypertension (HP:0100817)2.28391313
82Encephalitis (HP:0002383)2.28222375
83Mucopolysacchariduria (HP:0008155)2.27981944
84Urinary glycosaminoglycan excretion (HP:0003541)2.27981944
85Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.27425518
86Ventricular fibrillation (HP:0001663)2.23374938
87Supranuclear gaze palsy (HP:0000605)2.21570477
88Hypergammaglobulinemia (HP:0010702)2.20660078
89Hand muscle atrophy (HP:0009130)2.19105622
90Gastrointestinal infarctions (HP:0005244)2.18660332
91Recurrent viral infections (HP:0004429)2.18464415
92Poor eye contact (HP:0000817)2.17779920
93Hypertriglyceridemia (HP:0002155)2.17388774
94J-shaped sella turcica (HP:0002680)2.15470597
95Spastic gait (HP:0002064)2.14514939
96Glomerulonephritis (HP:0000099)2.14263157
97Epistaxis (HP:0000421)2.14135944
98Abnormality of ocular smooth pursuit (HP:0000617)2.13769228
99Inflammation of the large intestine (HP:0002037)2.13467866
100Hepatosplenomegaly (HP:0001433)2.12245190
101Abnormality of pyrimidine metabolism (HP:0004353)2.12218990
102Impaired smooth pursuit (HP:0007772)2.11804252
103Overriding aorta (HP:0002623)2.10743983
104Bundle branch block (HP:0011710)2.10261779
105Progressive neurologic deterioration (HP:0002344)2.09590127
106Vertebral compression fractures (HP:0002953)2.09438062
107Papilloma (HP:0012740)2.08288146
108Verrucae (HP:0200043)2.08288146
109Papilledema (HP:0001085)2.07839525
110Striae distensae (HP:0001065)2.06403388
111Postural instability (HP:0002172)2.05429683
112Long toe (HP:0010511)2.05371062
113Petechiae (HP:0000967)2.05311541
114Chronic otitis media (HP:0000389)2.04634896
115Abnormality of transition element cation homeostasis (HP:0011030)2.03388486
116Keratoconjunctivitis sicca (HP:0001097)2.03166308
117Myocardial infarction (HP:0001658)2.02878267
118Granulocytopenia (HP:0001913)2.02326454
119Clonus (HP:0002169)2.01967200
120Truncal ataxia (HP:0002078)2.01808365
121Spinal canal stenosis (HP:0003416)1.99957756
122Abnormality of T cells (HP:0002843)1.99943050
123Recurrent bronchitis (HP:0002837)1.99622293
124Obsessive-compulsive behavior (HP:0000722)1.99171697
125Joint hemorrhage (HP:0005261)1.98709103
126Broad metatarsal (HP:0001783)1.97527196
127Annular pancreas (HP:0001734)1.96452720
128Status epilepticus (HP:0002133)1.95412380
129Nasal polyposis (HP:0100582)1.94638006
130Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.93060811
131Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.91257651
132Pseudobulbar signs (HP:0002200)1.90900313
133Deep palmar crease (HP:0006191)1.90847810
134Hemoptysis (HP:0002105)1.90159082
135Frequent falls (HP:0002359)1.90011787
136Prolonged bleeding time (HP:0003010)1.89963195
137Axonal loss (HP:0003447)1.89361613
138Gingival bleeding (HP:0000225)1.87643721
139Recurrent cutaneous fungal infections (HP:0011370)1.86574034
140Chronic mucocutaneous candidiasis (HP:0002728)1.86574034
141Stridor (HP:0010307)1.86197417
142Ependymoma (HP:0002888)1.85881998
143Gangrene (HP:0100758)1.85301854
144Renal duplication (HP:0000075)1.84457956
145Aneurysm (HP:0002617)1.83674083
146Pulmonary embolism (HP:0002204)1.83504964
147Tetraplegia (HP:0002445)1.83307603
148Abnormality of the nasal mucosa (HP:0000433)1.83071506
149Polycythemia (HP:0001901)1.82971482
150Upper motor neuron abnormality (HP:0002127)1.82958846
151Bowel diverticulosis (HP:0005222)1.82506511
152Nuclear cataract (HP:0100018)1.82483647
153Thoracic kyphosis (HP:0002942)1.81786688
154Arterial thrombosis (HP:0004420)1.81700033
155Aortic aneurysm (HP:0004942)1.81477056
156Xanthomatosis (HP:0000991)1.80393269
157Severe short stature (HP:0003510)1.79916584
158Joint swelling (HP:0001386)1.78910229
159Glomerulopathy (HP:0100820)1.78791510
160Prolonged neonatal jaundice (HP:0006579)1.78591191
161Radial bowing (HP:0002986)1.77039915
162Chest pain (HP:0100749)1.76582834
163Long palpebral fissure (HP:0000637)1.74608604
164Neuronal loss in central nervous system (HP:0002529)1.74519362
165Basal cell carcinoma (HP:0002671)1.74259653
166Abnormality of binocular vision (HP:0011514)1.73815899
167Diplopia (HP:0000651)1.73815899
168Narrow palate (HP:0000189)1.73612318
169Ankyloglossia (HP:0010296)1.73233797
170Action tremor (HP:0002345)1.71056968
171Dilatation of the ascending aorta (HP:0005111)1.70333580
172Recurrent fungal infections (HP:0002841)1.69395548
173Vertebral arch anomaly (HP:0008438)1.69391341
174Elevated erythrocyte sedimentation rate (HP:0003565)1.69191210
175Broad palm (HP:0001169)1.67353646
176Bradykinesia (HP:0002067)1.66621337
177Focal motor seizures (HP:0011153)1.66034728
178Sacral dimple (HP:0000960)1.64500517
179Agammaglobulinemia (HP:0004432)1.64289232
180Autoimmune thrombocytopenia (HP:0001973)1.62457573
181Polygenic inheritance (HP:0010982)1.61057588
182Urinary bladder sphincter dysfunction (HP:0002839)1.60066132
183Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.59475696
184Short 4th metacarpal (HP:0010044)1.59475696

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.81367473
2PKN23.20302873
3NME23.01968908
4MAP4K12.98838027
5MAP3K112.81223628
6RIPK12.72680877
7SIK22.69837863
8EEF2K2.65697038
9MAP3K102.59030774
10PRPF4B2.55886138
11IRAK32.52748549
12TESK22.47935704
13MAP3K142.17480859
14FGFR42.17068661
15MAP2K32.13717500
16RIPK42.07952760
17SMG12.07071779
18IRAK41.98971600
19MAP3K91.98428393
20TAOK21.75409532
21BLK1.74400538
22MAP3K31.72818973
23MAP3K131.70756375
24MAP3K71.69418058
25TYRO31.67711231
26ERN11.63878422
27SIK11.62661896
28TAOK11.55486804
29GRK61.53303029
30PRKCH1.52960625
31ITK1.51598474
32ZAP701.48387221
33JAK11.47949359
34DAPK21.45057331
35TYK21.40934675
36CAMKK11.39955175
37PAK61.38919093
38KSR21.38366218
39TTN1.35786384
40KDR1.33260697
41JAK31.31122469
42PTK61.30168476
43STK381.28058672
44MARK21.25002277
45ALK1.24527367
46IKBKB1.23916155
47EPHA41.23809500
48NTRK21.23395950
49PRKD31.23237985
50TESK11.21916146
51EPHB11.20241619
52PIM21.16790352
53PDGFRA1.16394118
54CAMK1G1.08382430
55CDC42BPA1.07601795
56MAP2K21.06969627
57MARK11.04520125
58MAP3K11.02296279
59LMTK21.01821160
60FLT31.01261385
61FES1.00750587
62MATK0.99639131
63FGR0.98338977
64IRAK20.97539930
65NTRK30.97250728
66DAPK10.95872350
67FGFR30.95695218
68RET0.95188897
69STK100.95063311
70JAK20.94897767
71EPHA20.91954651
72KSR10.90252043
73SCYL20.87996523
74ICK0.87258027
75HCK0.85851573
76PAK40.85803285
77LRRK20.85497658
78PDK10.83562556
79TXK0.82018822
80MINK10.81180312
81LYN0.80533495
82HIPK20.73754065
83BTK0.73010052
84SYK0.72925646
85IKBKE0.72594327
86MAPK70.71906250
87MAPK110.71190412
88TAOK30.70659511
89CDK50.70541847
90PHKG10.69181855
91PHKG20.69181855
92STK110.68962042
93UHMK10.67392558
94CDK120.65379085
95BCKDK0.64725189
96LCK0.64661214
97CAMK1D0.64548112
98MTOR0.64061614
99GRK70.63284113
100DYRK1B0.63159533
101PIM10.61741539
102CAMK40.61717951
103TBK10.61279715
104ARAF0.61161412
105PDGFRB0.60047340
106TGFBR20.60039281
107PRKD20.59850256
108CSF1R0.59832454
109CAMK10.59127267
110CHUK0.58808282
111SGK30.58244312
112KIT0.58077334
113TNK20.58047820
114RPS6KC10.56483693
115RPS6KL10.56483693
116FGFR20.54953886
117BMX0.54831423
118MARK30.54054356
119ABL20.53941504
120PTK20.53528773
121RAF10.53007252
122CSK0.52347754
123FYN0.51909401
124MAP2K60.51575807
125MAPKAPK20.49677816
126BRSK10.49627308
127DMPK0.47396053
128MOS0.46533681
129PRKD10.46522518
130MAP3K80.46099282
131RPS6KA20.45772423
132PDPK10.44422459
133NTRK10.44323238
134MAP3K40.43750108
135PAK30.43079746
136CAMKK20.42150203
137NEK20.41663891
138SIK30.41292048
139MAPKAPK30.40681428
140RPS6KA60.40354783
141WNK10.40128640
142CDK60.39312927
143CDK40.39252519
144RPS6KA30.39029405
145MAPK120.38914257
146MST1R0.35092481
147DDR20.34903651
148MAP3K60.33059120

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.30703129
2Nitrogen metabolism_Homo sapiens_hsa009102.79093269
3Staphylococcus aureus infection_Homo sapiens_hsa051502.52340620
4Graft-versus-host disease_Homo sapiens_hsa053322.44167726
5Leishmaniasis_Homo sapiens_hsa051402.39314448
6Allograft rejection_Homo sapiens_hsa053302.23151505
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.20207729
8Primary immunodeficiency_Homo sapiens_hsa053402.18542539
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.12593534
10RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.05172822
11Autoimmune thyroid disease_Homo sapiens_hsa053201.95676433
12T cell receptor signaling pathway_Homo sapiens_hsa046601.88536317
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.86833002
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.79266853
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.78676251
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.70089384
17Lysosome_Homo sapiens_hsa041421.69585755
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.64849460
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.63959207
20TNF signaling pathway_Homo sapiens_hsa046681.60444997
21Type II diabetes mellitus_Homo sapiens_hsa049301.58294319
22Malaria_Homo sapiens_hsa051441.58228657
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.56395978
24Long-term potentiation_Homo sapiens_hsa047201.56253532
25Tuberculosis_Homo sapiens_hsa051521.56139371
26Herpes simplex infection_Homo sapiens_hsa051681.53527043
27B cell receptor signaling pathway_Homo sapiens_hsa046621.52827965
28Complement and coagulation cascades_Homo sapiens_hsa046101.49774330
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.49518476
30Olfactory transduction_Homo sapiens_hsa047401.48977363
31Pertussis_Homo sapiens_hsa051331.48541223
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.48345029
33Gastric acid secretion_Homo sapiens_hsa049711.45338245
34Insulin secretion_Homo sapiens_hsa049111.44676062
35Influenza A_Homo sapiens_hsa051641.41418711
36Carbohydrate digestion and absorption_Homo sapiens_hsa049731.41318347
37Toxoplasmosis_Homo sapiens_hsa051451.40924185
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.40428068
39Circadian entrainment_Homo sapiens_hsa047131.40082479
40Legionellosis_Homo sapiens_hsa051341.39718493
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.38594605
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.36912764
43mTOR signaling pathway_Homo sapiens_hsa041501.36612106
44Hematopoietic cell lineage_Homo sapiens_hsa046401.34553327
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.34141863
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.33782098
47Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.33005927
48Lysine degradation_Homo sapiens_hsa003101.29896928
49Shigellosis_Homo sapiens_hsa051311.29066822
50Prion diseases_Homo sapiens_hsa050201.25366648
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24948288
52GABAergic synapse_Homo sapiens_hsa047271.24370023
53Type I diabetes mellitus_Homo sapiens_hsa049401.22286057
54Thyroid hormone signaling pathway_Homo sapiens_hsa049191.22226281
55Apoptosis_Homo sapiens_hsa042101.22147793
56Cholinergic synapse_Homo sapiens_hsa047251.20703816
57Neurotrophin signaling pathway_Homo sapiens_hsa047221.20318023
58Morphine addiction_Homo sapiens_hsa050321.19354206
59Rheumatoid arthritis_Homo sapiens_hsa053231.19292758
60VEGF signaling pathway_Homo sapiens_hsa043701.17621128
61Chronic myeloid leukemia_Homo sapiens_hsa052201.17094693
62Hepatitis C_Homo sapiens_hsa051601.16935877
63Salivary secretion_Homo sapiens_hsa049701.16907418
64Salmonella infection_Homo sapiens_hsa051321.16076953
65Glutamatergic synapse_Homo sapiens_hsa047241.15980056
66Asthma_Homo sapiens_hsa053101.14965739
67Estrogen signaling pathway_Homo sapiens_hsa049151.14532863
68African trypanosomiasis_Homo sapiens_hsa051431.14257336
69Synaptic vesicle cycle_Homo sapiens_hsa047211.14174974
70Insulin resistance_Homo sapiens_hsa049311.14144798
71Non-small cell lung cancer_Homo sapiens_hsa052231.13872408
72Drug metabolism - other enzymes_Homo sapiens_hsa009831.13673080
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12671065
74Dopaminergic synapse_Homo sapiens_hsa047281.12024104
75Amphetamine addiction_Homo sapiens_hsa050311.11969326
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.11773362
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.08495567
78Cocaine addiction_Homo sapiens_hsa050301.08326988
79Oxytocin signaling pathway_Homo sapiens_hsa049211.08163879
80Notch signaling pathway_Homo sapiens_hsa043300.99154925
81Bile secretion_Homo sapiens_hsa049760.98559040
82GnRH signaling pathway_Homo sapiens_hsa049120.98524152
83Pentose phosphate pathway_Homo sapiens_hsa000300.98004593
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.97215265
85Glioma_Homo sapiens_hsa052140.96587652
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.96160119
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.95373360
88Osteoclast differentiation_Homo sapiens_hsa043800.95124154
89Glucagon signaling pathway_Homo sapiens_hsa049220.93360501
90Galactose metabolism_Homo sapiens_hsa000520.93227545
91Fructose and mannose metabolism_Homo sapiens_hsa000510.93117591
92Epstein-Barr virus infection_Homo sapiens_hsa051690.90595220
93Thyroid hormone synthesis_Homo sapiens_hsa049180.89963224
94Colorectal cancer_Homo sapiens_hsa052100.89913474
95Insulin signaling pathway_Homo sapiens_hsa049100.89747926
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89331231
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88901042
98Phagosome_Homo sapiens_hsa041450.88372278
99Endometrial cancer_Homo sapiens_hsa052130.87531357
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87047371
101Jak-STAT signaling pathway_Homo sapiens_hsa046300.86854734
102Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.86252787
103Bladder cancer_Homo sapiens_hsa052190.86200686
104Platelet activation_Homo sapiens_hsa046110.84453366
105Prolactin signaling pathway_Homo sapiens_hsa049170.82731173
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.82433543
107Acute myeloid leukemia_Homo sapiens_hsa052210.82365772
108Chemokine signaling pathway_Homo sapiens_hsa040620.81601214
109Renin secretion_Homo sapiens_hsa049240.81501542
110cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81391682
111cAMP signaling pathway_Homo sapiens_hsa040240.80295437
112Nicotine addiction_Homo sapiens_hsa050330.79969221
1132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.79160763
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79086744
115Sulfur relay system_Homo sapiens_hsa041220.77872551
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.77135670
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75944154
118Gap junction_Homo sapiens_hsa045400.74779930
119Arginine biosynthesis_Homo sapiens_hsa002200.74180044
120Endocytosis_Homo sapiens_hsa041440.73960319
121Pancreatic secretion_Homo sapiens_hsa049720.73773019
122Inositol phosphate metabolism_Homo sapiens_hsa005620.73494526
123Pancreatic cancer_Homo sapiens_hsa052120.72146130
124Choline metabolism in cancer_Homo sapiens_hsa052310.71686876
125Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71621132
126Viral myocarditis_Homo sapiens_hsa054160.71219490
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71088197
128Antigen processing and presentation_Homo sapiens_hsa046120.69672992
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68940675
130Calcium signaling pathway_Homo sapiens_hsa040200.65006424
131Viral carcinogenesis_Homo sapiens_hsa052030.63515768
132ErbB signaling pathway_Homo sapiens_hsa040120.63444316
133AMPK signaling pathway_Homo sapiens_hsa041520.62719404
134AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62484455
135Fatty acid biosynthesis_Homo sapiens_hsa000610.62415212
136Leukocyte transendothelial migration_Homo sapiens_hsa046700.62186049
137ABC transporters_Homo sapiens_hsa020100.60792977
138MAPK signaling pathway_Homo sapiens_hsa040100.60481390
139Phenylalanine metabolism_Homo sapiens_hsa003600.59435369
140Measles_Homo sapiens_hsa051620.58525275
141Hepatitis B_Homo sapiens_hsa051610.58325779
142Dilated cardiomyopathy_Homo sapiens_hsa054140.58005838
143Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57070534
144Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56627215
145Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53153662
146Rap1 signaling pathway_Homo sapiens_hsa040150.53107596
147Renal cell carcinoma_Homo sapiens_hsa052110.53096559
148Melanogenesis_Homo sapiens_hsa049160.52690044
149Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52671389
150Amoebiasis_Homo sapiens_hsa051460.52429806
151Proteoglycans in cancer_Homo sapiens_hsa052050.52398049
152HTLV-I infection_Homo sapiens_hsa051660.50888602
153Sphingolipid signaling pathway_Homo sapiens_hsa040710.47665787
154Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47104129
155Biosynthesis of amino acids_Homo sapiens_hsa012300.44682883
156PPAR signaling pathway_Homo sapiens_hsa033200.42287827
157HIF-1 signaling pathway_Homo sapiens_hsa040660.35959107
158Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35794157
159Caffeine metabolism_Homo sapiens_hsa002320.35519447
160Systemic lupus erythematosus_Homo sapiens_hsa053220.34725541
161Base excision repair_Homo sapiens_hsa034100.34317843
162Small cell lung cancer_Homo sapiens_hsa052220.33796517
163Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31593270
164Glycerophospholipid metabolism_Homo sapiens_hsa005640.27663579
165SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27373277

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