ZFP37

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcription factor that belongs to a large family of zinc finger proteins. A similar protein in mouse is thought to play a role in regulating the structures of the nucleolus and centromere in neurons. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)6.07190742
2regulation of sarcomere organization (GO:0060297)6.04637601
3positive regulation of oligodendrocyte differentiation (GO:0048714)5.16898251
4pyrimidine nucleobase catabolic process (GO:0006208)4.74060725
5limb bud formation (GO:0060174)4.58446877
6cilium or flagellum-dependent cell motility (GO:0001539)4.33462702
7nucleobase catabolic process (GO:0046113)4.06067504
8neural tube formation (GO:0001841)4.03496411
9regulation of timing of cell differentiation (GO:0048505)3.96431264
10motile cilium assembly (GO:0044458)3.88306319
11sperm motility (GO:0030317)3.84396921
12epithelial cilium movement (GO:0003351)3.83763578
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.81582324
14regulation of development, heterochronic (GO:0040034)3.80969604
15glycosphingolipid biosynthetic process (GO:0006688)3.78845992
16behavioral response to nicotine (GO:0035095)3.78078955
17acrosome reaction (GO:0007340)3.67293208
18eyelid development in camera-type eye (GO:0061029)3.59049102
19cell wall macromolecule catabolic process (GO:0016998)3.57908592
20cell wall macromolecule metabolic process (GO:0044036)3.57908592
21inositol phosphate catabolic process (GO:0071545)3.42460671
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.39876972
23regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.37861794
24multicellular organism reproduction (GO:0032504)3.37215737
25microtubule depolymerization (GO:0007019)3.35987449
26axonemal dynein complex assembly (GO:0070286)3.35683813
27central nervous system neuron axonogenesis (GO:0021955)3.32604071
28presynaptic membrane assembly (GO:0097105)3.32099852
29negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.31539866
30gamma-aminobutyric acid transport (GO:0015812)3.29801802
31protein localization to synapse (GO:0035418)3.24562144
32sialylation (GO:0097503)3.24068134
33cilium movement (GO:0003341)3.24047543
34neuron cell-cell adhesion (GO:0007158)3.23702689
35fusion of sperm to egg plasma membrane (GO:0007342)3.23292711
36startle response (GO:0001964)3.20805131
37atrial cardiac muscle cell action potential (GO:0086014)3.20467553
38microtubule polymerization or depolymerization (GO:0031109)3.17736974
39hippocampus development (GO:0021766)3.16150664
40dendrite morphogenesis (GO:0048813)3.16132010
41negative regulation of synaptic transmission, GABAergic (GO:0032229)3.14080495
42negative regulation of dendrite development (GO:2000171)3.12652793
43resolution of meiotic recombination intermediates (GO:0000712)3.12471540
44negative regulation of heart growth (GO:0061117)3.11568458
45negative regulation of cardiac muscle tissue growth (GO:0055022)3.11568458
46acrosome assembly (GO:0001675)3.11464082
47water-soluble vitamin biosynthetic process (GO:0042364)3.10885299
48nonmotile primary cilium assembly (GO:0035058)3.10102383
49regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.07330219
50regulation of MHC class II biosynthetic process (GO:0045346)3.04160008
51regulation of oligodendrocyte differentiation (GO:0048713)3.02887277
52presynaptic membrane organization (GO:0097090)3.02352388
53synaptic vesicle endocytosis (GO:0048488)3.01658401
54regulation of glutamate receptor signaling pathway (GO:1900449)3.01419366
55synapse assembly (GO:0007416)3.00529444
56keratinocyte development (GO:0003334)2.96533262
57postsynaptic membrane organization (GO:0001941)2.94946918
58calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.94901448
59protein-cofactor linkage (GO:0018065)2.92569299
60kynurenine metabolic process (GO:0070189)2.92149284
61synaptic vesicle docking involved in exocytosis (GO:0016081)2.91670154
62retinal ganglion cell axon guidance (GO:0031290)2.89409237
63vocalization behavior (GO:0071625)2.89404087
64male meiosis (GO:0007140)2.88915407
65cell migration in hindbrain (GO:0021535)2.88291692
66detection of light stimulus involved in visual perception (GO:0050908)2.86828746
67detection of light stimulus involved in sensory perception (GO:0050962)2.86828746
68positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.86221559
69hindbrain development (GO:0030902)2.86019135
70somite development (GO:0061053)2.82259762
71G-protein coupled receptor internalization (GO:0002031)2.81356931
72locomotory exploration behavior (GO:0035641)2.79609021
73regulation of heat generation (GO:0031650)2.78882591
74inner ear receptor stereocilium organization (GO:0060122)2.78872549
75sperm-egg recognition (GO:0035036)2.78490755
76cornea development in camera-type eye (GO:0061303)2.78367408
77histone H2A acetylation (GO:0043968)2.76190065
78calcium ion-dependent exocytosis (GO:0017156)2.75881214
79protein localization to cilium (GO:0061512)2.75606072
80retina layer formation (GO:0010842)2.75153084
81DNA double-strand break processing (GO:0000729)2.73450293
82olfactory bulb development (GO:0021772)2.73024281
83neurofilament cytoskeleton organization (GO:0060052)2.72866059
84negative regulation of translation, ncRNA-mediated (GO:0040033)2.71122575
85regulation of translation, ncRNA-mediated (GO:0045974)2.71122575
86negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.71122575
87ionotropic glutamate receptor signaling pathway (GO:0035235)2.70837915
88plasma membrane fusion (GO:0045026)2.69461707
89sympathetic nervous system development (GO:0048485)2.68567396
90DNA methylation involved in gamete generation (GO:0043046)2.68279703
91cilium assembly (GO:0042384)2.66638884
92central nervous system projection neuron axonogenesis (GO:0021952)2.65814646
93regulation of cilium movement (GO:0003352)2.65800833
94urinary tract smooth muscle contraction (GO:0014848)2.65632931
95fucose catabolic process (GO:0019317)2.64798684
96L-fucose metabolic process (GO:0042354)2.64798684
97L-fucose catabolic process (GO:0042355)2.64798684
98positive regulation of receptor biosynthetic process (GO:0010870)2.64244613
99cerebellar Purkinje cell differentiation (GO:0021702)2.63147006
100cilium organization (GO:0044782)2.63004373
101regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.62156330
102ectodermal placode formation (GO:0060788)2.60487059
103cilium morphogenesis (GO:0060271)2.60466854
104cellular ketone body metabolic process (GO:0046950)2.59847165
105positive regulation of amino acid transport (GO:0051957)2.59019536
106mitotic sister chromatid cohesion (GO:0007064)2.57986876
107neuronal action potential propagation (GO:0019227)2.57502682
108prenylation (GO:0097354)2.57304517
109protein prenylation (GO:0018342)2.57304517
110gamma-aminobutyric acid signaling pathway (GO:0007214)2.57240251
111calcium ion import (GO:0070509)2.56781149
112spermatid development (GO:0007286)2.56675348
113protein complex biogenesis (GO:0070271)2.53190039
114regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.53145182
115regulation of mitotic spindle checkpoint (GO:1903504)2.53145182
116regulation of telomere maintenance (GO:0032204)2.52506622
117ventricular system development (GO:0021591)2.52418439
118neurotransmitter-gated ion channel clustering (GO:0072578)2.52211570
119protein localization to microtubule cytoskeleton (GO:0072698)2.52088652
120dendrite development (GO:0016358)2.51948748
121appendage development (GO:0048736)2.51727119
122limb development (GO:0060173)2.51727119
123sperm capacitation (GO:0048240)2.50593199
124establishment of mitochondrion localization (GO:0051654)2.50576546
125head development (GO:0060322)2.49911293
126intraciliary transport (GO:0042073)2.49903366
127polyol catabolic process (GO:0046174)2.49801413
128glutamate receptor signaling pathway (GO:0007215)2.49497430
129piRNA metabolic process (GO:0034587)2.49413188
130magnesium ion transport (GO:0015693)2.49338935
131negative regulation of JUN kinase activity (GO:0043508)2.48780516
132negative regulation of cytosolic calcium ion concentration (GO:0051481)2.48641978
133synaptic transmission, glutamatergic (GO:0035249)2.48081615
134G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.46726320
135synaptic vesicle exocytosis (GO:0016079)2.44746513
136tachykinin receptor signaling pathway (GO:0007217)2.44401530
137peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.43330826
138regulation of short-term neuronal synaptic plasticity (GO:0048172)2.43219037
139C4-dicarboxylate transport (GO:0015740)2.43211053
140cerebral cortex radially oriented cell migration (GO:0021799)2.43006366
141positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.42763600
142neuronal action potential (GO:0019228)2.42469116
143regulation of spindle checkpoint (GO:0090231)2.41989940
144membrane depolarization during action potential (GO:0086010)2.41915179
145reproduction (GO:0000003)2.40867111
146tRNA methylation (GO:0030488)2.40596170
147membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.40403665
148mitochondrial respiratory chain complex assembly (GO:0033108)2.40395641
149exploration behavior (GO:0035640)2.39630654
150spinal cord motor neuron differentiation (GO:0021522)2.38967717
151negative regulation of axon extension (GO:0030517)2.38283849
152otic vesicle formation (GO:0030916)2.37553409
153regulation of synaptic transmission, glutamatergic (GO:0051966)2.36554212
154histone H3-K4 trimethylation (GO:0080182)2.36547363
155cell-cell recognition (GO:0009988)2.36468603
156regulation of rhodopsin mediated signaling pathway (GO:0022400)2.36350657
157axonal fasciculation (GO:0007413)2.36271467
158photoreceptor cell development (GO:0042461)2.35505298
159behavioral response to ethanol (GO:0048149)2.34118141
160negative regulation of cardiac muscle tissue development (GO:0055026)2.33624105
161regulation of action potential (GO:0098900)2.32605854
162positive regulation of heat generation (GO:0031652)2.32220459
163neuron-neuron synaptic transmission (GO:0007270)2.31094148
164specification of organ identity (GO:0010092)2.30222669
165neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.29656569
166regulation of non-canonical Wnt signaling pathway (GO:2000050)2.29504426
167regulation of fever generation (GO:0031620)2.29248685
168eye photoreceptor cell development (GO:0042462)2.29044479
169protein K11-linked deubiquitination (GO:0035871)2.28997795
170neuron recognition (GO:0008038)2.28656483
171regulation of synaptic vesicle exocytosis (GO:2000300)2.28572270
172photoreceptor cell maintenance (GO:0045494)2.27851421

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.57851643
2GBX2_23144817_ChIP-Seq_PC3_Human3.94304984
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.27942071
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.16686931
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.84417489
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.63799668
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.43307408
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.37504466
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.29324946
10CBX2_27304074_Chip-Seq_ESCs_Mouse2.23140416
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.22873036
12IGF1R_20145208_ChIP-Seq_DFB_Human2.18870663
13TAF15_26573619_Chip-Seq_HEK293_Human2.17633894
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.13392065
15* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.10785787
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.10156426
17BMI1_23680149_ChIP-Seq_NPCS_Mouse2.09316799
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.01713411
19FUS_26573619_Chip-Seq_HEK293_Human1.99440777
20JARID2_20064375_ChIP-Seq_MESCs_Mouse1.98518497
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.97134881
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.95596102
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.91935827
24RNF2_27304074_Chip-Seq_NSC_Mouse1.91283026
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90063873
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.89647557
27P300_19829295_ChIP-Seq_ESCs_Human1.89082243
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.88811415
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.83230201
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.80415195
31REST_21632747_ChIP-Seq_MESCs_Mouse1.78441512
32TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.76704025
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75348874
34SMAD4_21799915_ChIP-Seq_A2780_Human1.74280794
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.73448888
36SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.73279929
37NANOG_18555785_Chip-Seq_ESCs_Mouse1.68930628
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.68317031
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.67251367
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.66655722
41SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.66479835
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.64892816
43JARID2_20075857_ChIP-Seq_MESCs_Mouse1.62010931
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60323206
45IRF1_19129219_ChIP-ChIP_H3396_Human1.59071630
46VDR_22108803_ChIP-Seq_LS180_Human1.56538515
47EZH2_18974828_ChIP-Seq_MESCs_Mouse1.54869293
48RNF2_18974828_ChIP-Seq_MESCs_Mouse1.54869293
49EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.54738110
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.52556313
51ER_23166858_ChIP-Seq_MCF-7_Human1.52045067
52EWS_26573619_Chip-Seq_HEK293_Human1.51043780
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.50344497
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.50266239
55SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.49556473
56E2F1_18555785_Chip-Seq_ESCs_Mouse1.49430682
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46568264
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45627275
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45148552
60TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45148552
61STAT3_23295773_ChIP-Seq_U87_Human1.44455575
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44424641
63SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.42897856
64P53_22387025_ChIP-Seq_ESCs_Mouse1.42793996
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42782446
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42211233
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41501653
68SUZ12_27294783_Chip-Seq_ESCs_Mouse1.41430197
69SUZ12_18555785_Chip-Seq_ESCs_Mouse1.41029159
70CMYC_18555785_Chip-Seq_ESCs_Mouse1.39610524
71KLF5_20875108_ChIP-Seq_MESCs_Mouse1.38463455
72PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38198176
73MTF2_20144788_ChIP-Seq_MESCs_Mouse1.37884028
74CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.37496148
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36285965
76TCF4_23295773_ChIP-Seq_U87_Human1.35944748
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.35025559
78CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33672391
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.32596596
80RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.32419284
81AR_21572438_ChIP-Seq_LNCaP_Human1.31249020
82ZNF274_21170338_ChIP-Seq_K562_Hela1.30102056
83* STAT3_18555785_Chip-Seq_ESCs_Mouse1.29078149
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28287932
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27787765
86IKZF1_21737484_ChIP-ChIP_HCT116_Human1.27772081
87FLI1_21867929_ChIP-Seq_TH2_Mouse1.27553411
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27436814
89TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.26068190
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25929675
91P53_22127205_ChIP-Seq_FIBROBLAST_Human1.25687580
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25062368
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24891883
94CBP_20019798_ChIP-Seq_JUKART_Human1.24891883
95AR_25329375_ChIP-Seq_VCAP_Human1.24867760
96EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.24548740
97KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.23396976
98P300_18555785_Chip-Seq_ESCs_Mouse1.23035578
99ELK1_19687146_ChIP-ChIP_HELA_Human1.22214142
100SOX2_18555785_Chip-Seq_ESCs_Mouse1.22122814
101MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.21990539
102TCF4_22108803_ChIP-Seq_LS180_Human1.21733796
103SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21703270
104DROSHA_22980978_ChIP-Seq_HELA_Human1.21183995
105NOTCH1_21737748_ChIP-Seq_TLL_Human1.21128132
106* TP63_19390658_ChIP-ChIP_HaCaT_Human1.20979194
107TAL1_26923725_Chip-Seq_HPCs_Mouse1.20150514
108SOX9_26525672_Chip-Seq_HEART_Mouse1.18437624
109OCT4_18555785_Chip-Seq_ESCs_Mouse1.17964311
110EST1_17652178_ChIP-ChIP_JURKAT_Human1.17915176
111NMYC_18555785_Chip-Seq_ESCs_Mouse1.17197857
112RUNX2_22187159_ChIP-Seq_PCA_Human1.16385771
113GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16188819
114CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14856196
115KDM2B_26808549_Chip-Seq_REH_Human1.14764284
116BCAT_22108803_ChIP-Seq_LS180_Human1.14553911
117TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14384157
118SOX2_21211035_ChIP-Seq_LN229_Gbm1.13788508
119YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11959488
120TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11055512
121RUNX1_27457419_Chip-Seq_LIVER_Mouse1.09520197
122STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09308197
123KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.09255237
124GABP_17652178_ChIP-ChIP_JURKAT_Human1.08648197
125TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07972829
126SOX2_19829295_ChIP-Seq_ESCs_Human1.07503358
127NANOG_19829295_ChIP-Seq_ESCs_Human1.07503358
128CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07386296
129EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06851596
130* REST_18959480_ChIP-ChIP_MESCs_Mouse1.06645925
131CRX_20693478_ChIP-Seq_RETINA_Mouse1.03120688
132PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02512392
133FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02232149
134TP53_22573176_ChIP-Seq_HFKS_Human1.01819238

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.38052218
2MP0000566_synostosis3.20651487
3MP0003122_maternal_imprinting2.93547044
4MP0005410_abnormal_fertilization2.90266462
5MP0001188_hyperpigmentation2.82958093
6MP0005257_abnormal_intraocular_pressure2.78127383
7MP0003787_abnormal_imprinting2.77585239
8MP0005645_abnormal_hypothalamus_physiol2.49311729
9MP0002234_abnormal_pharynx_morphology2.49239529
10MP0004859_abnormal_synaptic_plasticity2.48816779
11MP0005646_abnormal_pituitary_gland2.42160057
12MP0003880_abnormal_central_pattern2.42158601
13MP0006292_abnormal_olfactory_placode2.37617109
14MP0002822_catalepsy2.26660278
15MP0001486_abnormal_startle_reflex2.21175711
16MP0003567_abnormal_fetal_cardiomyocyte2.10885728
17MP0005423_abnormal_somatic_nervous2.08718519
18MP0003121_genomic_imprinting2.05898017
19MP0008877_abnormal_DNA_methylation2.03336538
20MP0005551_abnormal_eye_electrophysiolog2.01242474
21MP0002277_abnormal_respiratory_mucosa1.96095793
22MP0003635_abnormal_synaptic_transmissio1.89695491
23MP0009046_muscle_twitch1.86022261
24MP0002572_abnormal_emotion/affect_behav1.79651498
25MP0001986_abnormal_taste_sensitivity1.79367563
26MP0006072_abnormal_retinal_apoptosis1.78096047
27MP0002102_abnormal_ear_morphology1.76117828
28MP0005171_absent_coat_pigmentation1.69535735
29MP0009745_abnormal_behavioral_response1.67830222
30MP0002063_abnormal_learning/memory/cond1.67465002
31MP0000778_abnormal_nervous_system1.66929213
32MP0002938_white_spotting1.65790779
33MP0002734_abnormal_mechanical_nocicepti1.65755029
34MP0003698_abnormal_male_reproductive1.63160285
35MP0002163_abnormal_gland_morphology1.61588995
36MP0002735_abnormal_chemical_nociception1.56318186
37MP0004215_abnormal_myocardial_fiber1.54471690
38MP0008789_abnormal_olfactory_epithelium1.53031576
39MP0002638_abnormal_pupillary_reflex1.52290301
40MP0001968_abnormal_touch/_nociception1.52099166
41MP0002064_seizures1.48068919
42MP0004142_abnormal_muscle_tone1.47006627
43MP0002557_abnormal_social/conspecific_i1.46921570
44MP0005367_renal/urinary_system_phenotyp1.46721652
45MP0000516_abnormal_urinary_system1.46721652
46MP0005253_abnormal_eye_physiology1.44903930
47MP0000631_abnormal_neuroendocrine_gland1.43478172
48MP0004270_analgesia1.43208258
49MP0002272_abnormal_nervous_system1.39715545
50MP0001984_abnormal_olfaction1.38329085
51MP0002184_abnormal_innervation1.37035610
52MP0005499_abnormal_olfactory_system1.35868116
53MP0005394_taste/olfaction_phenotype1.35868116
54MP0001299_abnormal_eye_distance/1.35801831
55MP0005379_endocrine/exocrine_gland_phen1.32671130
56MP0006276_abnormal_autonomic_nervous1.31331832
57MP0009250_abnormal_appendicular_skeleto1.30764926
58MP0002067_abnormal_sensory_capabilities1.30281824
59MP0003195_calcinosis1.30010401
60MP0000049_abnormal_middle_ear1.28650459
61MP0004147_increased_porphyrin_level1.27804235
62MP0004742_abnormal_vestibular_system1.27735829
63MP0002736_abnormal_nociception_after1.27279159
64MP0001440_abnormal_grooming_behavior1.19530831
65MP0001929_abnormal_gametogenesis1.17078507
66MP0003221_abnormal_cardiomyocyte_apopto1.14416730
67MP0005409_darkened_coat_color1.13618285
68MP0004133_heterotaxia1.13526856
69MP0001346_abnormal_lacrimal_gland1.12988033
70MP0002876_abnormal_thyroid_physiology1.12690425
71MP0001529_abnormal_vocalization1.12680865
72MP0003890_abnormal_embryonic-extraembry1.12096586
73MP0000372_irregular_coat_pigmentation1.09708078
74MP0003385_abnormal_body_wall1.08931948
75MP0003136_yellow_coat_color1.08884203
76MP0000015_abnormal_ear_pigmentation1.08720239
77MP0002882_abnormal_neuron_morphology1.08249141
78MP0010386_abnormal_urinary_bladder1.07803520
79MP0001485_abnormal_pinna_reflex1.05763355
80MP0002733_abnormal_thermal_nociception1.04205255
81MP0004885_abnormal_endolymph1.04047890
82MP0001963_abnormal_hearing_physiology1.03053046
83MP0002127_abnormal_cardiovascular_syste1.01870223
84MP0003718_maternal_effect1.00793052
85MP0003937_abnormal_limbs/digits/tail_de1.00711760
86MP0002909_abnormal_adrenal_gland1.00443147
87MP0001501_abnormal_sleep_pattern0.98251130
88MP0000955_abnormal_spinal_cord0.98037074
89MP0001970_abnormal_pain_threshold0.97412210
90MP0005075_abnormal_melanosome_morpholog0.97244360
91MP0002116_abnormal_craniofacial_bone0.97237934
92MP0005084_abnormal_gallbladder_morpholo0.97038912
93MP0002210_abnormal_sex_determination0.96943097
94MP0001849_ear_inflammation0.96891258
95MP0004043_abnormal_pH_regulation0.96751310
96MP0002233_abnormal_nose_morphology0.96513406
97MP0002752_abnormal_somatic_nervous0.95934732
98MP0000647_abnormal_sebaceous_gland0.95543088
99MP0008872_abnormal_physiological_respon0.95542654
100MP0001502_abnormal_circadian_rhythm0.94167461
101MP0005187_abnormal_penis_morphology0.93590777
102MP0002249_abnormal_larynx_morphology0.93221696
103MP0002152_abnormal_brain_morphology0.88668549
104MP0002090_abnormal_vision0.88440994
105MP0004085_abnormal_heartbeat0.87765396
106MP0003137_abnormal_impulse_conducting0.87729836
107MP0000026_abnormal_inner_ear0.87510503
108MP0001293_anophthalmia0.87160781
109MP0005195_abnormal_posterior_eye0.86839890
110MP0003755_abnormal_palate_morphology0.86292383
111MP0009697_abnormal_copulation0.86139853
112MP0005391_vision/eye_phenotype0.83372836
113MP0003941_abnormal_skin_development0.83290702
114MP0004811_abnormal_neuron_physiology0.82360785
115MP0000678_abnormal_parathyroid_gland0.81591238
116MP0002229_neurodegeneration0.80449360
117MP0003861_abnormal_nervous_system0.80354512
118MP0002653_abnormal_ependyma_morphology0.80004242
119MP0002161_abnormal_fertility/fecundity0.79710343
120MP0002177_abnormal_outer_ear0.79461750
121MP0001324_abnormal_eye_pigmentation0.78043951
122MP0002751_abnormal_autonomic_nervous0.75856978
123MP0003938_abnormal_ear_development0.74210553
124MP0002109_abnormal_limb_morphology0.72501912
125MP0002066_abnormal_motor_capabilities/c0.72421968
126MP0003942_abnormal_urinary_system0.71964313
127MP0003935_abnormal_craniofacial_develop0.71799803
128MP0009780_abnormal_chondrocyte_physiolo0.71735029
129MP0005386_behavior/neurological_phenoty0.71204068
130MP0004924_abnormal_behavior0.71204068
131MP0000462_abnormal_digestive_system0.70572633
132MP0003950_abnormal_plasma_membrane0.70384428
133MP0005248_abnormal_Harderian_gland0.70122483

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)5.37672782
2Absent/shortened dynein arms (HP:0200106)5.37672782
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.40793589
4Lissencephaly (HP:0001339)3.91820379
5Focal motor seizures (HP:0011153)3.71000779
6Abnormal respiratory motile cilium morphology (HP:0005938)3.69959408
7Abnormal respiratory epithelium morphology (HP:0012253)3.69959408
8Febrile seizures (HP:0002373)3.52894623
9Abnormal respiratory motile cilium physiology (HP:0012261)3.44229571
10Medial flaring of the eyebrow (HP:0010747)3.38560085
11Abnormal ciliary motility (HP:0012262)3.34843668
12Nephronophthisis (HP:0000090)3.30814304
13Congenital stationary night blindness (HP:0007642)3.19346020
14Molar tooth sign on MRI (HP:0002419)3.09622558
15Abnormality of midbrain morphology (HP:0002418)3.09622558
16Pachygyria (HP:0001302)3.03313270
17Hepatoblastoma (HP:0002884)3.01835844
18Epileptic encephalopathy (HP:0200134)3.00051010
19Congenital sensorineural hearing impairment (HP:0008527)2.89808678
20Methylmalonic acidemia (HP:0002912)2.86217756
21True hermaphroditism (HP:0010459)2.78154950
22Pancreatic fibrosis (HP:0100732)2.76709244
23Gait imbalance (HP:0002141)2.76001457
24Nephrogenic diabetes insipidus (HP:0009806)2.71107520
25Abnormality of the renal medulla (HP:0100957)2.70741539
26Abnormal hair whorl (HP:0010721)2.68647480
27Decreased central vision (HP:0007663)2.67923293
28Colon cancer (HP:0003003)2.66659031
29Renal cortical cysts (HP:0000803)2.61943403
30Congenital primary aphakia (HP:0007707)2.61589622
31Absent eyebrow (HP:0002223)2.53337744
32Hyperglycinemia (HP:0002154)2.45893537
33Inability to walk (HP:0002540)2.44838812
34Chronic hepatic failure (HP:0100626)2.44309861
35Rhinitis (HP:0012384)2.41330726
36Tubulointerstitial nephritis (HP:0001970)2.41292734
37Broad alveolar ridges (HP:0000187)2.41015263
38Aplasia/Hypoplasia of the sternum (HP:0006714)2.39207252
39Hypsarrhythmia (HP:0002521)2.39040460
40Long clavicles (HP:0000890)2.38373552
41Sclerocornea (HP:0000647)2.37563218
42EEG with generalized epileptiform discharges (HP:0011198)2.33375198
43Abnormality of the renal cortex (HP:0011035)2.32069037
44Chromosomal breakage induced by crosslinking agents (HP:0003221)2.31924177
45Epileptiform EEG discharges (HP:0011182)2.28880567
46Genital tract atresia (HP:0001827)2.27040190
47Volvulus (HP:0002580)2.26499774
48Widely spaced teeth (HP:0000687)2.25171957
49Progressive inability to walk (HP:0002505)2.24567882
50Abnormal rod and cone electroretinograms (HP:0008323)2.23890098
51White forelock (HP:0002211)2.21838259
52Vaginal atresia (HP:0000148)2.21325995
53Midline defect of the nose (HP:0004122)2.21279252
54Patchy hypopigmentation of hair (HP:0011365)2.18659737
55Cystic liver disease (HP:0006706)2.18191037
56Progressive cerebellar ataxia (HP:0002073)2.16879991
57Myelomeningocele (HP:0002475)2.16695979
58Septo-optic dysplasia (HP:0100842)2.14653053
59Pendular nystagmus (HP:0012043)2.13731654
60Narrow nasal bridge (HP:0000446)2.08724681
61Dyschromatopsia (HP:0007641)2.06634867
62Pancreatic cysts (HP:0001737)2.06570853
63Abnormality of incisor morphology (HP:0011063)2.06278583
64Postaxial hand polydactyly (HP:0001162)2.05510343
65Decreased testicular size (HP:0008734)2.03987526
66Aplasia/Hypoplasia of the tongue (HP:0010295)2.03964336
67Type II lissencephaly (HP:0007260)2.03930884
68Abnormality of the metopic suture (HP:0005556)2.03853505
69Chromsome breakage (HP:0040012)2.00930153
70Aplasia/Hypoplasia of the lens (HP:0008063)1.99189744
71Intestinal atresia (HP:0011100)1.98666018
72Absent speech (HP:0001344)1.98594217
73Attenuation of retinal blood vessels (HP:0007843)1.98453646
74Hemiparesis (HP:0001269)1.98126259
75Large for gestational age (HP:0001520)1.97215227
76Impaired vibration sensation in the lower limbs (HP:0002166)1.96441781
77Methylmalonic aciduria (HP:0012120)1.96285977
78Bony spicule pigmentary retinopathy (HP:0007737)1.94966745
79Decreased lacrimation (HP:0000633)1.94683548
80Micropenis (HP:0000054)1.94227259
81Neoplasm of the adrenal cortex (HP:0100641)1.93718823
82Hyperventilation (HP:0002883)1.93457968
83Broad foot (HP:0001769)1.93136964
84Scrotal hypoplasia (HP:0000046)1.92762930
85Cutaneous finger syndactyly (HP:0010554)1.92692766
86Alacrima (HP:0000522)1.91860972
87Poor coordination (HP:0002370)1.91764504
88Tachypnea (HP:0002789)1.90643318
89Adactyly (HP:0009776)1.90470193
90Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89454648
91Abnormality of the nasal septum (HP:0000419)1.88614341
92Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.88138656
93Preaxial hand polydactyly (HP:0001177)1.87602030
94Atonic seizures (HP:0010819)1.86334873
95Retinal dysplasia (HP:0007973)1.85603510
96Osteomalacia (HP:0002749)1.84983372
97Postaxial foot polydactyly (HP:0001830)1.84613553
98Abnormality of macular pigmentation (HP:0008002)1.84390928
99Dialeptic seizures (HP:0011146)1.83679834
100Hip dysplasia (HP:0001385)1.83316501
101Prolonged QT interval (HP:0001657)1.82894957
102Tented upper lip vermilion (HP:0010804)1.82617884
103Abnormality of the labia minora (HP:0012880)1.81983906
104Hypothermia (HP:0002045)1.80883177
105Focal seizures (HP:0007359)1.80248207
106Abnormality of the intervertebral disk (HP:0005108)1.80040046
107Congenital hepatic fibrosis (HP:0002612)1.79968454
108Spastic tetraplegia (HP:0002510)1.79765346
109Large eyes (HP:0001090)1.79743909
110Optic nerve hypoplasia (HP:0000609)1.79605092
111Neoplasm of the oral cavity (HP:0100649)1.78880124
112Abnormality of vitamin B metabolism (HP:0004340)1.77488840
113Amyotrophic lateral sclerosis (HP:0007354)1.77341410
114Polyphagia (HP:0002591)1.77000058
115Aplasia/Hypoplasia of the tibia (HP:0005772)1.76245350
116Protruding tongue (HP:0010808)1.76064072
117Conjugated hyperbilirubinemia (HP:0002908)1.75560843
118Absent rod-and cone-mediated responses on ERG (HP:0007688)1.75422716
119Ectopic kidney (HP:0000086)1.73157431
120Increased density of long bones (HP:0006392)1.73077611
121Abnormality of the astrocytes (HP:0100707)1.72189490
122Astrocytoma (HP:0009592)1.72189490
123Alveolar cell carcinoma (HP:0006519)1.71824034
124Narrow forehead (HP:0000341)1.71319337
125Aganglionic megacolon (HP:0002251)1.71097242
126Drooling (HP:0002307)1.71030850
127Excessive salivation (HP:0003781)1.71030850
128Cutaneous syndactyly (HP:0012725)1.70472851
129Neoplasm of the tracheobronchial system (HP:0100552)1.70014885
130Short foot (HP:0001773)1.69823495
131Growth hormone deficiency (HP:0000824)1.68901158
132Retinitis pigmentosa (HP:0000510)1.67994571
133Broad-based gait (HP:0002136)1.67467183
134Chorioretinal coloboma (HP:0000567)1.66887216
135Chronic bronchitis (HP:0004469)1.65795208
136Rib fusion (HP:0000902)1.65583193
137Astigmatism (HP:0000483)1.65305680
138Occipital encephalocele (HP:0002085)1.65111263
139Anencephaly (HP:0002323)1.63522136
140Highly arched eyebrow (HP:0002553)1.62460214
141Gastroesophageal reflux (HP:0002020)1.62312633
142Aplasia cutis congenita (HP:0001057)1.60628979
143Papillary thyroid carcinoma (HP:0002895)1.60457549
144Infertility (HP:0000789)1.60023641
145Small hand (HP:0200055)1.58486701
146Specific learning disability (HP:0001328)1.58055704
147Renal dysplasia (HP:0000110)1.57551908
148Labial hypoplasia (HP:0000066)1.57043878
149Choroideremia (HP:0001139)1.54926925
150Gaze-evoked nystagmus (HP:0000640)1.53804982

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K25.85655791
2NTRK33.96527204
3CASK3.85480100
4SIK33.41958870
5FRK3.29730603
6CDK82.73496851
7PINK12.36809193
8AKT32.14681338
9TNIK2.10040000
10MAP2K72.09107059
11MARK12.05358689
12CDK122.05049407
13EPHA32.04337385
14TRIM281.98673051
15MAPK131.95945004
16GRK71.93330322
17CSNK1G21.86037687
18INSRR1.83456280
19MAP3K41.80340702
20EPHA41.75977577
21SIK21.68227582
22PLK21.64047358
23BRD41.63940706
24NTRK21.52218957
25CDK31.44227653
26UHMK11.38476224
27PRPF4B1.36870073
28CAMK1G1.35688027
29PAK31.30147923
30PRKD31.26135896
31CSNK1G31.24702239
32LATS11.24134684
33CSNK1G11.23543333
34BMPR1B1.22804727
35SGK21.22391194
36ERBB31.22301872
37PDK31.20360231
38PDK41.20360231
39ZAK1.19456189
40LMTK21.18948744
41ADRBK21.14005158
42DYRK1B1.13275216
43VRK21.12047984
44CAMK1D1.08143424
45CSNK1A1L1.07655989
46SGK4941.06293016
47SGK2231.06293016
48MKNK21.05825028
49MARK21.03347926
50OXSR10.98546669
51CHEK20.96988236
52KSR10.94674819
53SRPK10.93876879
54NUAK10.92403422
55PDK20.92362061
56EIF2AK20.91939181
57BCR0.89352457
58MARK30.88089372
59WNK10.86515270
60PNCK0.81914967
61WNK30.80074305
62PHKG10.79782811
63PHKG20.79782811
64FGFR20.78496778
65MINK10.76387001
66YES10.75643968
67TAF10.75043129
68PLK30.73926019
69MAP3K130.73549920
70BMPR20.71609698
71MAP3K90.71607012
72SGK10.70393402
73CCNB10.69948382
74PAK60.69667590
75PKN10.68335259
76STK380.67224796
77MKNK10.66945315
78STK38L0.65910820
79CAMKK20.65480793
80STK160.64181108
81CAMK2A0.63718140
82IRAK20.63514723
83CDC42BPA0.63495344
84TAOK30.63353247
85PTK2B0.63014359
86TSSK60.62643270
87SGK30.61371413
88VRK10.61295879
89MAP3K60.61127250
90CLK10.61082028
91NEK60.60956972
92MAPK150.60796407
93STK390.60724939
94PRKCG0.60013401
95MUSK0.59531357
96PRKCE0.58851254
97DYRK30.58656083
98DYRK1A0.57474041
99CAMK10.56238151
100PRKG10.55972826
101WNK40.55862527
102ATR0.55606466
103TXK0.55345728
104RPS6KA40.55077063
105WEE10.54107680
106CSNK1A10.54026221
107GRK10.53739566
108CAMK2B0.53309163
109EPHB20.53049975
110EIF2AK30.52929562
111BRSK10.52030891
112GSK3B0.51755964
113BRAF0.51558696
114MAPK100.50530766
115ATM0.49708231
116DAPK20.49019117
117DYRK20.48611609
118CSNK1E0.48386897
119MAPK70.48229903
120MAPK140.48067475
121CDK50.47502189
122CSNK1D0.47093238
123STK30.46816787
124CAMK40.46472467
125BCKDK0.46340622
126PLK40.45536265
127BRSK20.45032306
128PRKCZ0.44955134
129CDK190.44613809
130MAP2K40.43407923
131ADRBK10.43389801
132STK110.42582357
133PRKACB0.42202469
134RPS6KA30.42112606
135CDC70.40735434
136PRKAA10.40123102
137DMPK0.38271067
138STK240.38035308
139CDK10.37264268
140ICK0.36139665
141MAPKAPK50.36052039
142CDK90.35966881
143PRKAA20.35542322
144PLK10.34185717
145CDK180.34068216
146PRKACA0.34037406
147CDK140.32583729
148CDK150.29754098
149FER0.29498286

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.52987234
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.42956202
3Phototransduction_Homo sapiens_hsa047442.70385528
4Butanoate metabolism_Homo sapiens_hsa006502.61249320
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.39406173
6Morphine addiction_Homo sapiens_hsa050322.21175296
7Synaptic vesicle cycle_Homo sapiens_hsa047212.13817493
8Protein export_Homo sapiens_hsa030602.10264576
9Circadian entrainment_Homo sapiens_hsa047132.08574113
10Taste transduction_Homo sapiens_hsa047422.03201431
11Olfactory transduction_Homo sapiens_hsa047401.98099787
12Insulin secretion_Homo sapiens_hsa049111.97868969
13Amphetamine addiction_Homo sapiens_hsa050311.96272493
14GABAergic synapse_Homo sapiens_hsa047271.91671086
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.84202943
16Glutamatergic synapse_Homo sapiens_hsa047241.82618712
17Basal transcription factors_Homo sapiens_hsa030221.80366132
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.79623088
19Serotonergic synapse_Homo sapiens_hsa047261.70152330
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.62835436
21Renin secretion_Homo sapiens_hsa049241.61230060
22Homologous recombination_Homo sapiens_hsa034401.59060163
23Steroid biosynthesis_Homo sapiens_hsa001001.58241624
24Linoleic acid metabolism_Homo sapiens_hsa005911.57097655
25Dopaminergic synapse_Homo sapiens_hsa047281.55593151
26Long-term potentiation_Homo sapiens_hsa047201.55314029
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51465415
28Axon guidance_Homo sapiens_hsa043601.51024891
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.49374597
30Cholinergic synapse_Homo sapiens_hsa047251.48703017
31Oxidative phosphorylation_Homo sapiens_hsa001901.46964261
32Cocaine addiction_Homo sapiens_hsa050301.44081980
33Propanoate metabolism_Homo sapiens_hsa006401.40473297
34Tryptophan metabolism_Homo sapiens_hsa003801.38782460
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38778318
36Calcium signaling pathway_Homo sapiens_hsa040201.34358245
37Non-homologous end-joining_Homo sapiens_hsa034501.31789755
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28994493
39RNA polymerase_Homo sapiens_hsa030201.28430980
40Long-term depression_Homo sapiens_hsa047301.28102567
41Salivary secretion_Homo sapiens_hsa049701.26513753
42Collecting duct acid secretion_Homo sapiens_hsa049661.24342129
43Type II diabetes mellitus_Homo sapiens_hsa049301.24050859
44Aldosterone synthesis and secretion_Homo sapiens_hsa049251.21286358
45cAMP signaling pathway_Homo sapiens_hsa040241.18976990
46Wnt signaling pathway_Homo sapiens_hsa043101.17970578
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.17744277
48Fanconi anemia pathway_Homo sapiens_hsa034601.16670977
49Oxytocin signaling pathway_Homo sapiens_hsa049211.16658983
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.14917442
51Spliceosome_Homo sapiens_hsa030401.14357181
52Parkinsons disease_Homo sapiens_hsa050121.12701224
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.12268936
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.10198315
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.06086766
56beta-Alanine metabolism_Homo sapiens_hsa004101.04610827
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00116290
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99964734
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98201205
60Selenocompound metabolism_Homo sapiens_hsa004500.97201261
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.96341393
62Huntingtons disease_Homo sapiens_hsa050160.95506036
63Alcoholism_Homo sapiens_hsa050340.95042068
64Gastric acid secretion_Homo sapiens_hsa049710.92252766
65RNA degradation_Homo sapiens_hsa030180.92163764
66Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.90586860
67Regulation of autophagy_Homo sapiens_hsa041400.89924229
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89770721
69MAPK signaling pathway_Homo sapiens_hsa040100.88922281
70Melanoma_Homo sapiens_hsa052180.88890662
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88505159
72Histidine metabolism_Homo sapiens_hsa003400.86475703
73Hedgehog signaling pathway_Homo sapiens_hsa043400.86021228
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.85909664
75Nucleotide excision repair_Homo sapiens_hsa034200.85051202
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.84952660
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83744578
78ErbB signaling pathway_Homo sapiens_hsa040120.83673465
79Sulfur metabolism_Homo sapiens_hsa009200.82090865
80Basal cell carcinoma_Homo sapiens_hsa052170.82014850
81Peroxisome_Homo sapiens_hsa041460.81740441
82Vibrio cholerae infection_Homo sapiens_hsa051100.81416121
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81171266
84Rheumatoid arthritis_Homo sapiens_hsa053230.79336776
85Dilated cardiomyopathy_Homo sapiens_hsa054140.79218965
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77113785
87Nitrogen metabolism_Homo sapiens_hsa009100.76666260
88mRNA surveillance pathway_Homo sapiens_hsa030150.76610414
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75511332
90Estrogen signaling pathway_Homo sapiens_hsa049150.75241104
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.74669800
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73681617
93Melanogenesis_Homo sapiens_hsa049160.73357225
94Cardiac muscle contraction_Homo sapiens_hsa042600.73014673
95Ras signaling pathway_Homo sapiens_hsa040140.72543615
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72466253
97Oocyte meiosis_Homo sapiens_hsa041140.71502073
98Caffeine metabolism_Homo sapiens_hsa002320.71228931
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70674384
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.69341923
101Circadian rhythm_Homo sapiens_hsa047100.69018644
102Retinol metabolism_Homo sapiens_hsa008300.67667350
103Fat digestion and absorption_Homo sapiens_hsa049750.67516677
104Lysine degradation_Homo sapiens_hsa003100.66429244
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66362358
106Gap junction_Homo sapiens_hsa045400.66189933
107ABC transporters_Homo sapiens_hsa020100.65696400
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65262210
109GnRH signaling pathway_Homo sapiens_hsa049120.64788147
110Dorso-ventral axis formation_Homo sapiens_hsa043200.64333799
111Fatty acid degradation_Homo sapiens_hsa000710.63300300
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63290437
113Glioma_Homo sapiens_hsa052140.62699815
114Glucagon signaling pathway_Homo sapiens_hsa049220.62209974
115Colorectal cancer_Homo sapiens_hsa052100.60832941
116Ether lipid metabolism_Homo sapiens_hsa005650.60601541
117Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59597697
118Steroid hormone biosynthesis_Homo sapiens_hsa001400.59332162
119Sphingolipid metabolism_Homo sapiens_hsa006000.58831294
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58038367
121Mineral absorption_Homo sapiens_hsa049780.57730282
122Purine metabolism_Homo sapiens_hsa002300.57407143
123Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55151742
124Rap1 signaling pathway_Homo sapiens_hsa040150.55097506
125Hippo signaling pathway_Homo sapiens_hsa043900.54247037
126Mismatch repair_Homo sapiens_hsa034300.53837205
127Pancreatic secretion_Homo sapiens_hsa049720.53777484
128Arginine and proline metabolism_Homo sapiens_hsa003300.53194202
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53174388
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52798320
131Metabolic pathways_Homo sapiens_hsa011000.52184273
132Alzheimers disease_Homo sapiens_hsa050100.51593308
133Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50568350
134Choline metabolism in cancer_Homo sapiens_hsa052310.49470328
135Chemical carcinogenesis_Homo sapiens_hsa052040.48819390
136RNA transport_Homo sapiens_hsa030130.48595611
137Glycerolipid metabolism_Homo sapiens_hsa005610.47812588
138TGF-beta signaling pathway_Homo sapiens_hsa043500.47623875
139Ovarian steroidogenesis_Homo sapiens_hsa049130.47526501
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47406213
141Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47235649
142Thyroid hormone synthesis_Homo sapiens_hsa049180.45561458
143Inositol phosphate metabolism_Homo sapiens_hsa005620.45009272
144Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.44789204
145Cysteine and methionine metabolism_Homo sapiens_hsa002700.44156598
146Prostate cancer_Homo sapiens_hsa052150.44029046
147Renal cell carcinoma_Homo sapiens_hsa052110.43334827
148Autoimmune thyroid disease_Homo sapiens_hsa053200.43111522
149Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42812193
150Fatty acid elongation_Homo sapiens_hsa000620.42482117
151Prolactin signaling pathway_Homo sapiens_hsa049170.41564591
152Glycosaminoglycan degradation_Homo sapiens_hsa005310.41367915
153Endometrial cancer_Homo sapiens_hsa052130.41108272
154Fatty acid metabolism_Homo sapiens_hsa012120.40656857
155Fatty acid biosynthesis_Homo sapiens_hsa000610.40531646
156Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38125951

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