ZFAND5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of male gonad development (GO:2000020)5.13944984
2cellular response to follicle-stimulating hormone stimulus (GO:0071372)4.36159582
3regulation of male gonad development (GO:2000018)4.01567925
4regulation of cAMP-dependent protein kinase activity (GO:2000479)3.89200392
5definitive hemopoiesis (GO:0060216)3.77065998
6cellular response to gonadotropin stimulus (GO:0071371)3.76041571
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.75951697
8neuronal action potential propagation (GO:0019227)3.50039105
9hemoglobin metabolic process (GO:0020027)3.37435815
10pyrimidine nucleobase catabolic process (GO:0006208)3.29474173
11cellular response to thyroid hormone stimulus (GO:0097067)3.20792021
12regulation of transforming growth factor beta2 production (GO:0032909)3.19191863
13glucocorticoid biosynthetic process (GO:0006704)3.18001682
14presynaptic membrane organization (GO:0097090)3.08947573
15cellular response to epinephrine stimulus (GO:0071872)3.08357751
16response to follicle-stimulating hormone (GO:0032354)3.06205566
17regulation of cell communication by electrical coupling (GO:0010649)3.00516457
18sarcoplasmic reticulum calcium ion transport (GO:0070296)2.99304174
19presynaptic membrane assembly (GO:0097105)2.90440518
20glucocorticoid metabolic process (GO:0008211)2.89735403
21cardiac muscle adaptation (GO:0014887)2.87867713
22cardiac muscle hypertrophy in response to stress (GO:0014898)2.87867713
23muscle hypertrophy in response to stress (GO:0003299)2.87867713
24synaptic vesicle maturation (GO:0016188)2.85206678
25Rap protein signal transduction (GO:0032486)2.85186038
26negative regulation of systemic arterial blood pressure (GO:0003085)2.84940272
27response to epinephrine (GO:0071871)2.82384204
28ionotropic glutamate receptor signaling pathway (GO:0035235)2.79466143
29response to gonadotropin (GO:0034698)2.69899107
30microglial cell activation (GO:0001774)2.69039792
31regulation of relaxation of muscle (GO:1901077)2.68781008
32androgen biosynthetic process (GO:0006702)2.67827732
33neuron remodeling (GO:0016322)2.67384890
34synaptic vesicle docking involved in exocytosis (GO:0016081)2.66090240
35epithelial cell differentiation involved in kidney development (GO:0035850)2.65090945
36negative regulation of homotypic cell-cell adhesion (GO:0034111)2.63482316
37regulation of cardioblast differentiation (GO:0051890)2.62938588
38regulation of neuron projection regeneration (GO:0070570)2.61826679
39regulation of axon regeneration (GO:0048679)2.61826679
40amyloid precursor protein catabolic process (GO:0042987)2.60854160
41embryonic process involved in female pregnancy (GO:0060136)2.58539944
42negative regulation of interleukin-17 production (GO:0032700)2.57833273
43negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.56868149
44regulation of cardiac muscle cell contraction (GO:0086004)2.56781978
45cranial nerve morphogenesis (GO:0021602)2.56379674
46neurofilament cytoskeleton organization (GO:0060052)2.52565678
47long term synaptic depression (GO:0060292)2.52546870
48axonal fasciculation (GO:0007413)2.51098714
49regulation of germinal center formation (GO:0002634)2.50677693
50metanephric mesenchyme development (GO:0072075)2.50248793
51regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.49871986
52lymphoid progenitor cell differentiation (GO:0002320)2.49038920
53cellular response to fluid shear stress (GO:0071498)2.48650248
54striated muscle hypertrophy (GO:0014897)2.48156903
55cardiac muscle hypertrophy (GO:0003300)2.48071648
56regulation of female gonad development (GO:2000194)2.48066956
57germinal center formation (GO:0002467)2.47676387
58short-term memory (GO:0007614)2.45915679
59positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.45177563
60endocardial cushion development (GO:0003197)2.45021792
61nucleobase catabolic process (GO:0046113)2.44834445
62negative regulation of T-helper cell differentiation (GO:0045623)2.43034378
63negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.43034378
64skeletal muscle adaptation (GO:0043501)2.42044736
65vesicle transport along microtubule (GO:0047496)2.41115643
66regulation of dendritic spine development (GO:0060998)2.41031898
67regulation of actin filament-based movement (GO:1903115)2.40529588
68glutamate receptor signaling pathway (GO:0007215)2.40377658
69macrophage activation (GO:0042116)2.40361924
70regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.37747289
71skeletal muscle fiber development (GO:0048741)2.35623898
72positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.33432698
73sodium ion export (GO:0071436)2.32614580
74regulation of long-term neuronal synaptic plasticity (GO:0048169)2.31051779
75regulation of pigment cell differentiation (GO:0050932)2.30573042
76negative regulation of neurotransmitter transport (GO:0051589)2.30563640
77regulation of platelet aggregation (GO:0090330)2.30349594
78SMAD protein complex assembly (GO:0007183)2.30098404
79male genitalia development (GO:0030539)2.29294592
80cellular potassium ion homeostasis (GO:0030007)2.28602406
81regulation of short-term neuronal synaptic plasticity (GO:0048172)2.27886074
82cerebral cortex radially oriented cell migration (GO:0021799)2.27820819
83interleukin-6-mediated signaling pathway (GO:0070102)2.27496643
84macroautophagy (GO:0016236)2.27102791
85heparin metabolic process (GO:0030202)2.27000201
86heparin biosynthetic process (GO:0030210)2.27000201
87regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.26787225
88photoreceptor cell differentiation (GO:0046530)2.26687974
89eye photoreceptor cell differentiation (GO:0001754)2.26687974
90cell communication by electrical coupling (GO:0010644)2.26556937
91response to muramyl dipeptide (GO:0032495)2.26527505
92positive regulation of cardiac muscle cell differentiation (GO:2000727)2.26090780
93platelet dense granule organization (GO:0060155)2.25270196
94regulation of dendritic spine morphogenesis (GO:0061001)2.23958458
95cellular response to antibiotic (GO:0071236)2.23408566
96positive regulation of vasculogenesis (GO:2001214)2.22618780
97atrioventricular valve morphogenesis (GO:0003181)2.22306799
98regulation of synaptic vesicle exocytosis (GO:2000300)2.21806144
99cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.21082548
100regulation of gonadotropin secretion (GO:0032276)2.21050226
101positive regulation of cellular amide metabolic process (GO:0034250)2.20745691
102RNA destabilization (GO:0050779)2.17253420
103regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.16673914
104regulation of T-helper 2 cell differentiation (GO:0045628)2.16406649
105glial cell proliferation (GO:0014009)2.15635638
106membrane assembly (GO:0071709)2.14338535
107postsynaptic membrane organization (GO:0001941)2.14151677
108positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.12760488
109adhesion of symbiont to host (GO:0044406)2.12165040
110kidney mesenchyme development (GO:0072074)2.11834559
111regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.11691831
112regulation of synaptic vesicle transport (GO:1902803)2.10453565
113dendritic spine organization (GO:0097061)2.10225675
114nerve growth factor signaling pathway (GO:0038180)2.09117600
115response to monoamine (GO:0071867)2.08977215
116response to catecholamine (GO:0071869)2.08977215
117regulation of establishment of cell polarity (GO:2000114)2.08667047
118peptidyl-threonine dephosphorylation (GO:0035970)2.07648255
119negative regulation of neurotransmitter secretion (GO:0046929)2.07356075
120cellular response to catecholamine stimulus (GO:0071870)2.07266999
121cellular response to monoamine stimulus (GO:0071868)2.07266999
122cerebral cortex cell migration (GO:0021795)2.07045275
123megakaryocyte development (GO:0035855)2.06427162
124neuron recognition (GO:0008038)2.06290315
125gastrulation with mouth forming second (GO:0001702)2.06289127
126muscle hypertrophy (GO:0014896)2.06134867
127negative regulation of synaptic transmission, GABAergic (GO:0032229)2.06071270
128negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.05824959
129negative regulation of dendrite morphogenesis (GO:0050774)2.04919620
130phagocytosis, recognition (GO:0006910)2.04312915
131C21-steroid hormone biosynthetic process (GO:0006700)2.03894021
132muscle atrophy (GO:0014889)2.03728072
133regulation of skeletal muscle cell differentiation (GO:2001014)2.03569567
134striated muscle atrophy (GO:0014891)2.02930666
135positive regulation of macrophage cytokine production (GO:0060907)2.02560361
136positive regulation of p38MAPK cascade (GO:1900745)2.02289201
137positive regulation of nitric-oxide synthase activity (GO:0051000)2.02160090
138neuronal ion channel clustering (GO:0045161)2.01781519
139positive regulation of astrocyte differentiation (GO:0048711)2.01598556
140amino acid import (GO:0043090)2.01060169
141negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.00773535
142sex determination (GO:0007530)2.00724089
143gamma-aminobutyric acid signaling pathway (GO:0007214)2.00717642
144growth hormone secretion (GO:0030252)2.00338934
145G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.00063023
146transmission of nerve impulse (GO:0019226)1.99946298
147regulation of homotypic cell-cell adhesion (GO:0034110)1.99945760
148lipopolysaccharide-mediated signaling pathway (GO:0031663)1.99814894
149negative regulation of smooth muscle contraction (GO:0045986)1.99019250
150interferon-gamma-mediated signaling pathway (GO:0060333)1.98835892
151macrophage activation involved in immune response (GO:0002281)1.98689701
152regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)1.98644614
153regulation of p38MAPK cascade (GO:1900744)1.97950153
154organelle transport along microtubule (GO:0072384)1.96902823
155protein localization to synapse (GO:0035418)1.96263993
156glutamate secretion (GO:0014047)1.96196243
157negative regulation of exocytosis (GO:0045920)1.95959934
158response to corticosterone (GO:0051412)1.95221847
159lens morphogenesis in camera-type eye (GO:0002089)1.95184669
160neuron cell-cell adhesion (GO:0007158)1.95180907
161synaptic transmission, glutamatergic (GO:0035249)1.95131536
162vocalization behavior (GO:0071625)1.95055997
163axon extension (GO:0048675)1.94510256
164myeloid cell activation involved in immune response (GO:0002275)1.94484089
165response to protozoan (GO:0001562)1.94341436
166regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)1.94172447
167skeletal muscle tissue regeneration (GO:0043403)1.94102188
168myotube cell development (GO:0014904)1.93596645
169interleukin-1-mediated signaling pathway (GO:0070498)1.93513953
170regulation of T-helper 1 cell differentiation (GO:0045625)1.93311961
171synaptic vesicle exocytosis (GO:0016079)1.93202428
172neutrophil activation involved in immune response (GO:0002283)1.93086263
173endoplasmic reticulum organization (GO:0007029)1.92854738
174exploration behavior (GO:0035640)1.92732478
175angiogenesis involved in wound healing (GO:0060055)1.92251970
176monocyte chemotaxis (GO:0002548)1.92000259
177regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)1.91336275
178regulation of interleukin-12 biosynthetic process (GO:0045075)1.91185234
179layer formation in cerebral cortex (GO:0021819)1.90396958
180negative regulation of inclusion body assembly (GO:0090084)1.90384576
181regulation of neuronal synaptic plasticity (GO:0048168)1.90056604
182positive regulation of myoblast differentiation (GO:0045663)1.89416457
183negative regulation of erythrocyte differentiation (GO:0045647)1.89014506

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SMAD_19615063_ChIP-ChIP_OVARY_Human2.98844512
2STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.86020488
3BP1_19119308_ChIP-ChIP_Hs578T_Human2.80892434
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.53537627
5EZH2_22144423_ChIP-Seq_EOC_Human2.44071605
6GBX2_23144817_ChIP-Seq_PC3_Human2.42210240
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.17709850
8IGF1R_20145208_ChIP-Seq_DFB_Human2.14588432
9* CDX2_19796622_ChIP-Seq_MESCs_Mouse2.09103920
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.03067633
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.97915513
12POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93108795
13TAF15_26573619_Chip-Seq_HEK293_Human1.88419138
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.88088068
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.87732564
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.86196961
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85118658
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.84652918
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.83241397
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.79679233
21* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77858571
22RNF2_18974828_ChIP-Seq_MESCs_Mouse1.77573495
23EZH2_18974828_ChIP-Seq_MESCs_Mouse1.77573495
24AR_21572438_ChIP-Seq_LNCaP_Human1.73489694
25MTF2_20144788_ChIP-Seq_MESCs_Mouse1.68356328
26ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.68053843
27SCL_19346495_ChIP-Seq_HPC-7_Human1.67487566
28* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.65281513
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64372633
30GATA2_21666600_ChIP-Seq_HMVEC_Human1.63092123
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.61541828
32NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.60217404
33NRF2_20460467_ChIP-Seq_MEFs_Mouse1.60217404
34CLOCK_20551151_ChIP-Seq_293T_Human1.58562881
35WT1_19549856_ChIP-ChIP_CCG9911_Human1.56122989
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.55514897
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55370095
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.55202591
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.53150395
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50646068
41ESR1_20079471_ChIP-ChIP_T-47D_Human1.49788067
42IRF8_22096565_ChIP-ChIP_GC-B_Human1.49743146
43FUS_26573619_Chip-Seq_HEK293_Human1.49704926
44P300_19829295_ChIP-Seq_ESCs_Human1.49338971
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.49079105
46JARID2_20075857_ChIP-Seq_MESCs_Mouse1.47326129
47TP53_16413492_ChIP-PET_HCT116_Human1.44156931
48IRF8_21731497_ChIP-ChIP_J774_Mouse1.44020292
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.42281418
50SUZ12_27294783_Chip-Seq_ESCs_Mouse1.41555840
51IRF8_27001747_Chip-Seq_BMDM_Mouse1.40889070
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40353996
53STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.39574783
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38869803
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.38821786
56VDR_24787735_ChIP-Seq_THP-1_Human1.37849389
57* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36852923
58TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35267863
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.35221308
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.34914114
61* PIAS1_25552417_ChIP-Seq_VCAP_Human1.34873141
62SALL4_18804426_ChIP-ChIP_XEN_Mouse1.32763434
63AR_25329375_ChIP-Seq_VCAP_Human1.32594319
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29417053
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29415369
66RUNX_20019798_ChIP-Seq_JUKART_Human1.28874712
67SMAD4_21799915_ChIP-Seq_A2780_Human1.28733764
68STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.28177625
69SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.27819360
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27336053
71STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.22719148
72AHR_22903824_ChIP-Seq_MCF-7_Human1.21762566
73NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20949488
74* TP53_18474530_ChIP-ChIP_U2OS_Human1.20008980
75TRIM28_21343339_ChIP-Seq_HEK293_Human1.19979335
76MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.18745016
77* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18164599
78ER_23166858_ChIP-Seq_MCF-7_Human1.16969011
79* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16388270
80RNF2_27304074_Chip-Seq_NSC_Mouse1.16291665
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.16206743
82PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15651782
83TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14093306
84SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13106982
85* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.13019480
86LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12638466
87TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.12567509
88BCAT_22108803_ChIP-Seq_LS180_Human1.10704081
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10235584
90EP300_21415370_ChIP-Seq_HL-1_Mouse1.09795687
91* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09322715
92* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08863023
93FLI1_27457419_Chip-Seq_LIVER_Mouse1.08057701
94* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.07423696
95* RXR_22108803_ChIP-Seq_LS180_Human1.07413872
96NANOG_18555785_Chip-Seq_ESCs_Mouse1.06990399
97CJUN_26792858_Chip-Seq_BT549_Human1.06857348
98* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06326215
99VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04412963
100TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03489608
101RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02736149
102CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.02540476
103* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00979267
104CBX2_27304074_Chip-Seq_ESCs_Mouse1.00546221
105TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99300256
106BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98567131
107EWS_26573619_Chip-Seq_HEK293_Human0.98092333
108MYB_21317192_ChIP-Seq_ERMYB_Mouse0.98060469
109P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97888760
110SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97484369
111ISL1_27105846_Chip-Seq_CPCs_Mouse0.96732249
112SOX2_20726797_ChIP-Seq_SW620_Human0.96462201
113NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96338039
114* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96136169
115CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95749842
116E2F1_18555785_Chip-Seq_ESCs_Mouse0.94758662
117ESR1_21235772_ChIP-Seq_MCF-7_Human0.94442456
118EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93296354
119PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93068882
120SOX2_21211035_ChIP-Seq_LN229_Gbm0.92717484
121VDR_22108803_ChIP-Seq_LS180_Human0.92444800
122SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.92355496
123FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92335637
124MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92264225
125FLI1_21867929_ChIP-Seq_TH2_Mouse0.91952602
126ARNT_22903824_ChIP-Seq_MCF-7_Human0.91922068
127RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.91880381
128RUNX2_22187159_ChIP-Seq_PCA_Human0.91258393
129* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.91003132
130GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90764961
131RING1B_27294783_Chip-Seq_ESCs_Mouse0.90578291
132RARB_27405468_Chip-Seq_BRAIN_Mouse0.90148719
133EZH2_27294783_Chip-Seq_NPCs_Mouse0.89925672
134SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89908067
135TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89553542
136NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.89434843

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.82449400
2MP0003880_abnormal_central_pattern3.08489801
3MP0004145_abnormal_muscle_electrophysio3.02054538
4MP0002009_preneoplasia2.60369448
5MP0003724_increased_susceptibility_to2.55826127
6MP0004270_analgesia2.53050006
7MP0008004_abnormal_stomach_pH2.45395652
8MP0001188_hyperpigmentation2.35185640
9MP0004510_myositis2.22328793
10MP0004147_increased_porphyrin_level2.09696301
11MP0003635_abnormal_synaptic_transmissio2.05867793
12MP0003300_gastrointestinal_ulcer2.04068753
13MP0002102_abnormal_ear_morphology2.03734985
14MP0005171_absent_coat_pigmentation1.91209353
15MP0002332_abnormal_exercise_endurance1.91095578
16MP0001851_eye_inflammation1.87060038
17MP0001835_abnormal_antigen_presentation1.85531397
18MP0000639_abnormal_adrenal_gland1.84550714
19MP0004484_altered_response_of1.78936127
20MP0009384_cardiac_valve_regurgitation1.74600582
21MP0009379_abnormal_foot_pigmentation1.74350182
22MP0003221_abnormal_cardiomyocyte_apopto1.74322762
23MP0009745_abnormal_behavioral_response1.73704907
24MP0001501_abnormal_sleep_pattern1.72136842
25MP0005248_abnormal_Harderian_gland1.70628486
26* MP0003828_pulmonary_edema1.67361805
27MP0000383_abnormal_hair_follicle1.67005269
28MP0003303_peritoneal_inflammation1.65148146
29MP0002148_abnormal_hypersensitivity_rea1.64376383
30MP0003011_delayed_dark_adaptation1.63339346
31MP0008789_abnormal_olfactory_epithelium1.62573241
32MP0010678_abnormal_skin_adnexa1.60801462
33MP0000372_irregular_coat_pigmentation1.60359023
34MP0005499_abnormal_olfactory_system1.60013088
35MP0005394_taste/olfaction_phenotype1.60013088
36MP0003656_abnormal_erythrocyte_physiolo1.58021128
37MP0000920_abnormal_myelination1.56621969
38MP0001529_abnormal_vocalization1.54905014
39MP0009785_altered_susceptibility_to1.47597149
40MP0004215_abnormal_myocardial_fiber1.46193733
41MP0005409_darkened_coat_color1.45988800
42MP0001968_abnormal_touch/_nociception1.44701992
43MP0000751_myopathy1.43372232
44MP0003329_amyloid_beta_deposits1.42516341
45MP0002063_abnormal_learning/memory/cond1.42324971
46MP0001984_abnormal_olfaction1.41955242
47MP0006138_congestive_heart_failure1.34875118
48MP0001486_abnormal_startle_reflex1.33995679
49MP0000465_gastrointestinal_hemorrhage1.33787698
50MP0002734_abnormal_mechanical_nocicepti1.33052406
51MP0002272_abnormal_nervous_system1.32635707
52MP0004130_abnormal_muscle_cell1.32338917
53MP0002106_abnormal_muscle_physiology1.32092191
54MP0002064_seizures1.31692811
55MP0003279_aneurysm1.30872253
56MP0005174_abnormal_tail_pigmentation1.30869174
57MP0002419_abnormal_innate_immunity1.30688466
58MP0002254_reproductive_system_inflammat1.30613767
59MP0009046_muscle_twitch1.28500236
60MP0004084_abnormal_cardiac_muscle1.28338581
61MP0002896_abnormal_bone_mineralization1.28114047
62MP0002822_catalepsy1.27846393
63MP0001879_abnormal_lymphatic_vessel1.27386591
64MP0000013_abnormal_adipose_tissue1.26650160
65MP0001440_abnormal_grooming_behavior1.26442882
66MP0010386_abnormal_urinary_bladder1.26108100
67MP0005000_abnormal_immune_tolerance1.23556331
68MP0000015_abnormal_ear_pigmentation1.21980120
69MP0008569_lethality_at_weaning1.19839602
70MP0002166_altered_tumor_susceptibility1.19697369
71MP0005310_abnormal_salivary_gland1.17739895
72MP0003075_altered_response_to1.17481995
73MP0008995_early_reproductive_senescence1.17126378
74MP0002006_tumorigenesis1.17016541
75MP0000747_muscle_weakness1.16818674
76MP0005595_abnormal_vascular_smooth1.16080981
77MP0001545_abnormal_hematopoietic_system1.15146298
78MP0005397_hematopoietic_system_phenotyp1.15146298
79MP0005187_abnormal_penis_morphology1.15096790
80MP0005671_abnormal_response_to1.14490250
81MP0002067_abnormal_sensory_capabilities1.13367046
82MP0000749_muscle_degeneration1.13332873
83* MP0003091_abnormal_cell_migration1.13125651
84MP0005257_abnormal_intraocular_pressure1.12981431
85MP0002972_abnormal_cardiac_muscle1.11834198
86MP0002736_abnormal_nociception_after1.11211599
87MP0002095_abnormal_skin_pigmentation1.10926916
88MP0000750_abnormal_muscle_regeneration1.10189685
89MP0002735_abnormal_chemical_nociception1.08557961
90MP0010234_abnormal_vibrissa_follicle1.08500992
91MP0000778_abnormal_nervous_system1.07308055
92MP0004885_abnormal_endolymph1.06173436
93MP0001177_atelectasis1.05845555
94MP0002127_abnormal_cardiovascular_syste1.04184869
95MP0004742_abnormal_vestibular_system1.04092463
96MP0002452_abnormal_antigen_presenting1.03509405
97MP0004811_abnormal_neuron_physiology1.03270836
98MP0005025_abnormal_response_to1.02243153
99MP0005167_abnormal_blood-brain_barrier1.01842182
100MP0000049_abnormal_middle_ear1.01682836
101MP0002723_abnormal_immune_serum1.01421382
102MP0000569_abnormal_digit_pigmentation1.00278898
103MP0002877_abnormal_melanocyte_morpholog0.99411980
104MP0001986_abnormal_taste_sensitivity0.99344540
105MP0001502_abnormal_circadian_rhythm0.97373945
106MP0000681_abnormal_thyroid_gland0.97309585
107MP0003633_abnormal_nervous_system0.96073485
108* MP0002133_abnormal_respiratory_system0.95545259
109* MP0005388_respiratory_system_phenotype0.95545259
110MP0005369_muscle_phenotype0.95397580
111MP0005253_abnormal_eye_physiology0.93926161
112MP0003634_abnormal_glial_cell0.92421699
113MP0004133_heterotaxia0.90542762
114MP0001905_abnormal_dopamine_level0.90172788
115MP0004087_abnormal_muscle_fiber0.89637026
116MP0003690_abnormal_glial_cell0.89117719
117MP0002277_abnormal_respiratory_mucosa0.88740867
118MP0005620_abnormal_muscle_contractility0.88660529
119MP0006276_abnormal_autonomic_nervous0.88219812
120MP0002090_abnormal_vision0.87801715
121MP0001819_abnormal_immune_cell0.87623641
122MP0002572_abnormal_emotion/affect_behav0.87584563
123MP0000759_abnormal_skeletal_muscle0.87511749
124MP0003646_muscle_fatigue0.87005939
125MP0002420_abnormal_adaptive_immunity0.86873837
126MP0005166_decreased_susceptibility_to0.86662656
127MP0001542_abnormal_bone_strength0.86337229
128MP0000516_abnormal_urinary_system0.85933657
129MP0005367_renal/urinary_system_phenotyp0.85933657
130MP0002184_abnormal_innervation0.85626843
131MP0003890_abnormal_embryonic-extraembry0.84267896
132MP0006082_CNS_inflammation0.84163445
133MP0005464_abnormal_platelet_physiology0.83722074
134MP0006292_abnormal_olfactory_placode0.83443607
135MP0004085_abnormal_heartbeat0.83103961
136MP0002909_abnormal_adrenal_gland0.82678709
137MP0000343_altered_response_to0.82120438
138MP0002233_abnormal_nose_morphology0.81447857
139MP0002998_abnormal_bone_remodeling0.81161409
140MP0005646_abnormal_pituitary_gland0.80547899
141MP0004036_abnormal_muscle_relaxation0.80299548
142MP0002882_abnormal_neuron_morphology0.79447937
143MP0002557_abnormal_social/conspecific_i0.78983168
144MP0000462_abnormal_digestive_system0.78762523
145MP0002733_abnormal_thermal_nociception0.78353342
146MP0005386_behavior/neurological_phenoty0.78287512
147MP0004924_abnormal_behavior0.78287512
148MP0000537_abnormal_urethra_morphology0.77622846
149MP0010368_abnormal_lymphatic_system0.77589966
150MP0003941_abnormal_skin_development0.77099621
151MP0005423_abnormal_somatic_nervous0.76952059
152MP0003436_decreased_susceptibility_to0.76344882
153MP0004808_abnormal_hematopoietic_stem0.75738512
154MP0004883_abnormal_blood_vessel0.75490644
155MP0001970_abnormal_pain_threshold0.74662369
156MP0002066_abnormal_motor_capabilities/c0.73389127
157MP0000604_amyloidosis0.72437090
158MP0005164_abnormal_response_to0.72349317
159MP0000955_abnormal_spinal_cord0.72123649
160MP0001533_abnormal_skeleton_physiology0.70816658

Predicted human phenotypes

RankGene SetZ-score
1Anomalous pulmonary venous return (HP:0010772)5.09844743
2Abnormality of the pulmonary veins (HP:0011718)4.74518106
3Nemaline bodies (HP:0003798)4.65672366
4Focal motor seizures (HP:0011153)4.61177989
5Muscle fiber inclusion bodies (HP:0100299)4.55502611
6Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.52405079
7Mutism (HP:0002300)3.43970476
8Myositis (HP:0100614)3.39431369
9Distal arthrogryposis (HP:0005684)3.38566172
10Nonprogressive disorder (HP:0003680)3.33592361
11Testicular neoplasm (HP:0010788)3.28458267
12Muscle hypertrophy of the lower extremities (HP:0008968)3.23388786
13Visual hallucinations (HP:0002367)3.17191142
14Gonadal dysgenesis (HP:0000133)3.10488709
15Shoulder girdle muscle weakness (HP:0003547)3.07312885
16Optic neuritis (HP:0100653)3.06266347
17Retrobulbar optic neuritis (HP:0100654)3.06266347
18Recurrent abscess formation (HP:0002722)3.03326253
19Calf muscle hypertrophy (HP:0008981)2.83726422
20Large earlobe (HP:0009748)2.82694870
21Hematochezia (HP:0002573)2.70918503
22Sex reversal (HP:0012245)2.70606667
23Abnormal sex determination (HP:0012244)2.70606667
24Rimmed vacuoles (HP:0003805)2.69338708
25Progressive inability to walk (HP:0002505)2.68206371
26Febrile seizures (HP:0002373)2.65637501
27Recurrent bacterial skin infections (HP:0005406)2.64843496
28Inappropriate behavior (HP:0000719)2.62484307
29Relative macrocephaly (HP:0004482)2.62429685
30Lower limb muscle weakness (HP:0007340)2.59300293
31Atonic seizures (HP:0010819)2.58492014
32Disinhibition (HP:0000734)2.57102710
33EMG: myopathic abnormalities (HP:0003458)2.56764802
34Orchitis (HP:0100796)2.55657488
35Prostate neoplasm (HP:0100787)2.54960651
36Focal seizures (HP:0007359)2.52956039
37Growth hormone excess (HP:0000845)2.52294617
38Vitreoretinal degeneration (HP:0000655)2.51802952
39Inability to walk (HP:0002540)2.50684531
40Segmental peripheral demyelination/remyelination (HP:0003481)2.48958767
41Arterial tortuosity (HP:0005116)2.44907143
42Hypoplastic left heart (HP:0004383)2.44049933
43Broad-based gait (HP:0002136)2.43588144
44Neurofibrillary tangles (HP:0002185)2.43195144
45Abnormality of the corticospinal tract (HP:0002492)2.42834871
46Thick nail (HP:0001805)2.41512035
47Papillary thyroid carcinoma (HP:0002895)2.41249380
48Abnormality of the hip-girdle musculature (HP:0001445)2.40494967
49Abnormality of the musculature of the pelvis (HP:0001469)2.40494967
50Type 1 muscle fiber predominance (HP:0003803)2.38273706
51Amyotrophic lateral sclerosis (HP:0007354)2.37356864
52Absent speech (HP:0001344)2.35924677
53Exercise-induced muscle cramps (HP:0003710)2.34475181
54Metaphyseal dysplasia (HP:0100255)2.33686143
55Gaze-evoked nystagmus (HP:0000640)2.31893389
56Ulnar claw (HP:0001178)2.31574522
57Vertebral arch anomaly (HP:0008438)2.30959313
58Urinary urgency (HP:0000012)2.29997063
59Epileptic encephalopathy (HP:0200134)2.29836255
60Elevated erythrocyte sedimentation rate (HP:0003565)2.25862280
61Lower limb amyotrophy (HP:0007210)2.24486423
62Subaortic stenosis (HP:0001682)2.21992341
63Abnormality of the left ventricular outflow tract (HP:0011103)2.21992341
64Limb-girdle muscle weakness (HP:0003325)2.21781286
65Vascular tortuosity (HP:0004948)2.20253634
66Heterochromia iridis (HP:0001100)2.20168214
67Spastic gait (HP:0002064)2.18218169
68Fetal akinesia sequence (HP:0001989)2.17770179
69Impaired vibration sensation in the lower limbs (HP:0002166)2.16875400
70Myotonia (HP:0002486)2.15511480
71Abnormality of the lower motor neuron (HP:0002366)2.15193087
72Neck muscle weakness (HP:0000467)2.14815835
73Keratoconjunctivitis sicca (HP:0001097)2.13787728
74Muscle fiber splitting (HP:0003555)2.13585289
75Absent phalangeal crease (HP:0006109)2.12818795
76Progressive cerebellar ataxia (HP:0002073)2.12536301
77Abnormality of the neuromuscular junction (HP:0003398)2.12478617
78Fatigable weakness (HP:0003473)2.12478617
79Calcaneovalgus deformity (HP:0001848)2.12381593
80Choroideremia (HP:0001139)2.12275605
81Type 2 muscle fiber atrophy (HP:0003554)2.12098925
82Split foot (HP:0001839)2.11023080
83Weak cry (HP:0001612)2.04939998
84Abnormal eating behavior (HP:0100738)2.02957565
85Exercise-induced myalgia (HP:0003738)2.02906982
86Round ear (HP:0100830)2.02546107
87Pelvic girdle muscle weakness (HP:0003749)2.01384326
88Keratoconjunctivitis (HP:0001096)2.00923869
89Ankle clonus (HP:0011448)2.00310744
90Aortic aneurysm (HP:0004942)1.99767241
91Hypothermia (HP:0002045)1.99647141
92Neuronal loss in central nervous system (HP:0002529)1.98903792
93Papilledema (HP:0001085)1.98221916
94Acute myeloid leukemia (HP:0004808)1.96999385
95Hypoplastic heart (HP:0001961)1.95216478
96Peripheral hypomyelination (HP:0007182)1.94622781
97Urinary bladder sphincter dysfunction (HP:0002839)1.94113568
98Prolonged bleeding time (HP:0003010)1.94070644
99Absent frontal sinuses (HP:0002688)1.94030446
100Hyperpituitarism (HP:0010514)1.93201360
101Deformed tarsal bones (HP:0008119)1.92903718
102Abnormal finger flexion creases (HP:0006143)1.92365906
103Action tremor (HP:0002345)1.91398771
104Abnormality of the calf musculature (HP:0001430)1.90672576
105Protrusio acetabuli (HP:0003179)1.89836179
106Polyphagia (HP:0002591)1.89233213
107Vertigo (HP:0002321)1.89208943
108Supranuclear gaze palsy (HP:0000605)1.88689178
109Palpebral edema (HP:0100540)1.88657089
110Onion bulb formation (HP:0003383)1.87990133
111Myokymia (HP:0002411)1.87951012
112Gowers sign (HP:0003391)1.86991670
113Hyperphosphatemia (HP:0002905)1.86839663
114Limb dystonia (HP:0002451)1.86750055
115Facial diplegia (HP:0001349)1.85522004
116Distal lower limb amyotrophy (HP:0008944)1.83000424
117Limb-girdle muscle atrophy (HP:0003797)1.82464881
118Scanning speech (HP:0002168)1.82454579
119Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.82422313
120Degeneration of the lateral corticospinal tracts (HP:0002314)1.82422313
121Exotropia (HP:0000577)1.82165192
122Protruding tongue (HP:0010808)1.81540882
123Turricephaly (HP:0000262)1.81066848
124Asymmetric septal hypertrophy (HP:0001670)1.80698632
125Male infertility (HP:0003251)1.80341265
126Dialeptic seizures (HP:0011146)1.79896319
127Spinal cord lesions (HP:0100561)1.79503383
128Syringomyelia (HP:0003396)1.79503383
129Clumsiness (HP:0002312)1.78754233
130Hypercortisolism (HP:0001578)1.75757069
131Genetic anticipation (HP:0003743)1.75573148
132White forelock (HP:0002211)1.75293984
133Muscle fiber atrophy (HP:0100295)1.75250465
134Increased neuronal autofluorescent lipopigment (HP:0002074)1.74782455
135Diminished motivation (HP:0000745)1.74701260
136Capillary hemangiomas (HP:0005306)1.74583888
137Submucous cleft hard palate (HP:0000176)1.73652961
138Germ cell neoplasia (HP:0100728)1.73208983
139Patchy hypopigmentation of hair (HP:0011365)1.73136963
140Stridor (HP:0010307)1.72137662
141Myopathic facies (HP:0002058)1.72017071
142Apathy (HP:0000741)1.71923413
143Excessive salivation (HP:0003781)1.70236454
144Drooling (HP:0002307)1.70236454
145Steppage gait (HP:0003376)1.69355588
146Increased cerebral lipofuscin (HP:0011813)1.69217625
147Diplopia (HP:0000651)1.68936236
148Abnormality of binocular vision (HP:0011514)1.68936236
149Abnormality of macrophages (HP:0004311)1.68905304
150Mitral stenosis (HP:0001718)1.68450390
151Overgrowth (HP:0001548)1.68330290
152Accelerated skeletal maturation (HP:0005616)1.65885697
153Cupped ear (HP:0000378)1.64454394
154Periauricular skin pits (HP:0100277)1.64166088
155Preauricular pit (HP:0004467)1.64166088
156Rapidly progressive (HP:0003678)1.60335136
157Increased variability in muscle fiber diameter (HP:0003557)1.59975741
158Tetraparesis (HP:0002273)1.59680700
159Hypoventilation (HP:0002791)1.58589439
160Cubitus valgus (HP:0002967)1.58555687
161Hyperventilation (HP:0002883)1.56049511
162Postural instability (HP:0002172)1.55255063
163Narrow nasal bridge (HP:0000446)1.54506939
164Bronchomalacia (HP:0002780)1.54155848
165Abnormality of the shoulder girdle musculature (HP:0001435)1.53578866
166Spastic paraplegia (HP:0001258)1.53479819
167Gait ataxia (HP:0002066)1.53181658
168Intention tremor (HP:0002080)1.53080888

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.74061907
2TNIK3.05347411
3PRPF4B2.81061308
4CDK192.79455958
5TGFBR22.49552612
6MUSK2.29362356
7AKT32.28970519
8SIK32.15545863
9MAP2K72.04222857
10MAPKAPK52.00188150
11GRK71.96573044
12BMPR21.96210364
13BMPR1B1.93742276
14MAP3K131.88973845
15UHMK11.86798964
16RAF11.76191007
17BRD41.74418345
18IKBKE1.73021997
19KSR21.71733202
20MAP3K91.67106686
21MAP3K141.64801252
22NTRK31.64687936
23ERBB31.59890492
24TIE11.58381794
25KSR11.57310677
26KIT1.57226339
27LATS11.55127494
28MAPK151.50932809
29ARAF1.50123484
30CAMKK21.49830087
31SIK21.49344467
32MAP3K121.46399545
33FES1.42775058
34TEC1.41152986
35MAPK71.40383890
36TBK11.40349197
37DYRK1B1.38036089
38MOS1.37984745
39EPHA41.37227629
40TRPM71.25186007
41PAK31.25136606
42ADRBK21.23222049
43TAOK21.22140509
44EPHA31.21594961
45CASK1.20797900
46MKNK21.18303355
47DMPK1.17451277
48MAP3K61.17312947
49LMTK21.16049033
50GRK51.15465959
51OBSCN1.15373072
52MARK11.14768025
53CAMK41.13499772
54TTN1.13076878
55MKNK11.11980036
56PINK11.09255287
57IKBKB1.09121048
58TRIM281.08201620
59MAP3K71.04193455
60STK38L1.02075008
61STK381.02051686
62MINK11.01897135
63MAPK130.98898318
64PHKG20.98807341
65PHKG10.98807341
66SGK30.96935018
67MAP2K30.96843585
68TGFBR10.92617389
69MAP3K10.90806273
70STK240.90321700
71CSNK1G20.89744079
72MARK30.88838113
73ACVR1B0.86257683
74MAP4K20.83905725
75EPHB10.83683529
76WNK30.82624386
77MATK0.81108697
78YES10.79666890
79MAP3K50.79367493
80CSNK1A1L0.77737050
81MAPK120.77650758
82NUAK10.77367263
83DDR20.77240687
84MAP2K40.76723787
85ERBB40.76667155
86CDK30.76374260
87DYRK30.76234982
88DYRK1A0.75510397
89JAK10.73049361
90MARK20.72967181
91NEK90.71906911
92STK390.69947291
93FGR0.69387807
94PTK2B0.69203509
95CSNK1G30.68663282
96RPS6KA20.68622768
97MAP3K20.67966681
98CAMK2A0.67846235
99CDK90.66438675
100MYLK0.66245755
101CDK80.65849515
102RIPK10.65357943
103PAK60.64074000
104NEK60.63340307
105NTRK20.63269800
106PIK3CA0.63220676
107CDK60.62589036
108PLK20.62314393
109OXSR10.60795910
110SGK20.60758133
111CSNK1G10.60195765
112PDGFRA0.59687968
113LIMK10.59498971
114FER0.58983100
115ROCK20.58893889
116CAMK2B0.57774624
117RPS6KC10.57248760
118RPS6KL10.57248760
119NLK0.56821395
120PDGFRB0.56653312
121PDK20.56583513
122PRKD20.54896673
123PRKCE0.53922513
124ROCK10.53266150
125CSF1R0.52715092
126GSK3A0.52205971
127MAPK100.51646978
128NTRK10.50944135
129DYRK20.49963974
130CAMK10.49776792
131PDK10.49016240
132SGK10.48815759
133TAOK10.48760543
134CDK50.48426922
135IRAK30.48053006
136MAP3K40.48020861
137DAPK20.46043239
138FGFR20.45025271
139MAPKAPK30.42620313
140LATS20.42459742
141BCR0.41780542
142STK110.41438486
143SGK4940.40791866
144SGK2230.40791866
145FGFR30.40350187
146PRKG10.40262124
147RET0.40254366
148IRAK40.39942724
149PKN10.39321592

Predicted pathways (KEGG)

RankGene SetZ-score
1Long-term potentiation_Homo sapiens_hsa047201.61065949
2Nicotine addiction_Homo sapiens_hsa050331.53562749
3Long-term depression_Homo sapiens_hsa047301.50998837
4Osteoclast differentiation_Homo sapiens_hsa043801.45918519
5Circadian entrainment_Homo sapiens_hsa047131.44349676
6Leishmaniasis_Homo sapiens_hsa051401.43794590
7Glutamatergic synapse_Homo sapiens_hsa047241.42904515
8Oxytocin signaling pathway_Homo sapiens_hsa049211.42809762
9Toll-like receptor signaling pathway_Homo sapiens_hsa046201.39081995
10B cell receptor signaling pathway_Homo sapiens_hsa046621.38896869
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.37077597
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.34823512
13Salmonella infection_Homo sapiens_hsa051321.33274035
14Pertussis_Homo sapiens_hsa051331.32652967
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.31257535
16GnRH signaling pathway_Homo sapiens_hsa049121.31163180
17Renin secretion_Homo sapiens_hsa049241.30267393
18Steroid biosynthesis_Homo sapiens_hsa001001.29680929
19Salivary secretion_Homo sapiens_hsa049701.29638927
20TNF signaling pathway_Homo sapiens_hsa046681.27405771
21Rheumatoid arthritis_Homo sapiens_hsa053231.27128139
22Dorso-ventral axis formation_Homo sapiens_hsa043201.25166544
23Circadian rhythm_Homo sapiens_hsa047101.23568662
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.22637818
25Platelet activation_Homo sapiens_hsa046111.21773090
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19319966
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.17754468
28Serotonergic synapse_Homo sapiens_hsa047261.17647263
29African trypanosomiasis_Homo sapiens_hsa051431.17137083
30Morphine addiction_Homo sapiens_hsa050321.15773198
31Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.15135648
32Malaria_Homo sapiens_hsa051441.14705356
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.14108440
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12985536
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12843143
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.12253188
37Tuberculosis_Homo sapiens_hsa051521.11595132
38Amphetamine addiction_Homo sapiens_hsa050311.11225235
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10242375
40Calcium signaling pathway_Homo sapiens_hsa040201.08125474
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06433756
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05561786
43Cholinergic synapse_Homo sapiens_hsa047251.04976676
44Insulin secretion_Homo sapiens_hsa049111.04637218
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02345233
46Pancreatic secretion_Homo sapiens_hsa049721.02327153
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01899637
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01828988
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.01547331
50MAPK signaling pathway_Homo sapiens_hsa040101.00837967
51cAMP signaling pathway_Homo sapiens_hsa040241.00576963
52Gastric acid secretion_Homo sapiens_hsa049710.99817643
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.99192612
54Choline metabolism in cancer_Homo sapiens_hsa052310.98934636
55ErbB signaling pathway_Homo sapiens_hsa040120.98583433
56Adherens junction_Homo sapiens_hsa045200.98085872
57GABAergic synapse_Homo sapiens_hsa047270.97366213
58Regulation of autophagy_Homo sapiens_hsa041400.96795621
59NF-kappa B signaling pathway_Homo sapiens_hsa040640.96065885
60VEGF signaling pathway_Homo sapiens_hsa043700.94892794
61Shigellosis_Homo sapiens_hsa051310.94774653
62Axon guidance_Homo sapiens_hsa043600.94491451
63Chemokine signaling pathway_Homo sapiens_hsa040620.94143962
64Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92979849
65Dopaminergic synapse_Homo sapiens_hsa047280.92381926
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91842733
67Ras signaling pathway_Homo sapiens_hsa040140.89561892
68Renal cell carcinoma_Homo sapiens_hsa052110.89036416
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88284811
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.87830955
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87305962
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.86596526
73Prolactin signaling pathway_Homo sapiens_hsa049170.86519131
74Toxoplasmosis_Homo sapiens_hsa051450.85913483
75Estrogen signaling pathway_Homo sapiens_hsa049150.85712067
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.83806989
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83607799
78Influenza A_Homo sapiens_hsa051640.83455400
79Hepatitis B_Homo sapiens_hsa051610.83286209
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.83194305
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82932771
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.80628017
83Melanogenesis_Homo sapiens_hsa049160.79691830
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.79457617
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78259435
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.78139419
87Olfactory transduction_Homo sapiens_hsa047400.77999066
88Synaptic vesicle cycle_Homo sapiens_hsa047210.77365075
89Inositol phosphate metabolism_Homo sapiens_hsa005620.76870452
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76796650
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76653019
92Taste transduction_Homo sapiens_hsa047420.76154930
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75713032
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74814109
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.74523907
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74262590
97Pancreatic cancer_Homo sapiens_hsa052120.73533485
98AMPK signaling pathway_Homo sapiens_hsa041520.73340452
99Gap junction_Homo sapiens_hsa045400.72899883
100Glioma_Homo sapiens_hsa052140.72679299
101Apoptosis_Homo sapiens_hsa042100.72670513
102Bile secretion_Homo sapiens_hsa049760.72146314
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72077820
104TGF-beta signaling pathway_Homo sapiens_hsa043500.71567848
105Focal adhesion_Homo sapiens_hsa045100.70744561
106Measles_Homo sapiens_hsa051620.70717588
107Rap1 signaling pathway_Homo sapiens_hsa040150.70643646
108T cell receptor signaling pathway_Homo sapiens_hsa046600.69667736
109Hematopoietic cell lineage_Homo sapiens_hsa046400.69632550
110Hippo signaling pathway_Homo sapiens_hsa043900.69511637
111Tight junction_Homo sapiens_hsa045300.68277159
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67960570
113Cocaine addiction_Homo sapiens_hsa050300.67301538
114FoxO signaling pathway_Homo sapiens_hsa040680.67221369
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.66464388
116Wnt signaling pathway_Homo sapiens_hsa043100.66201679
117Phagosome_Homo sapiens_hsa041450.64868093
118Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64340235
119Dilated cardiomyopathy_Homo sapiens_hsa054140.64207994
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64055290
121Amoebiasis_Homo sapiens_hsa051460.63680811
122Type II diabetes mellitus_Homo sapiens_hsa049300.62527645
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62327874
124Endometrial cancer_Homo sapiens_hsa052130.61982243
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61936439
126Insulin signaling pathway_Homo sapiens_hsa049100.60915172
127Ovarian steroidogenesis_Homo sapiens_hsa049130.60877815
128Protein digestion and absorption_Homo sapiens_hsa049740.60245552
129Prion diseases_Homo sapiens_hsa050200.59637545
130Steroid hormone biosynthesis_Homo sapiens_hsa001400.56533864
131Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55024045
132Proteoglycans in cancer_Homo sapiens_hsa052050.53900521
133Hedgehog signaling pathway_Homo sapiens_hsa043400.53323192
134mTOR signaling pathway_Homo sapiens_hsa041500.52996852
135Glucagon signaling pathway_Homo sapiens_hsa049220.52843933
136Colorectal cancer_Homo sapiens_hsa052100.52272531
137Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51715624
138Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48129771
139Lysosome_Homo sapiens_hsa041420.47963660
140Endocytosis_Homo sapiens_hsa041440.45726117

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