ZDHHC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.16528446
2ribosomal small subunit assembly (GO:0000028)6.26576237
3regulation of mitochondrial translation (GO:0070129)4.86093278
4cytochrome complex assembly (GO:0017004)4.33774533
5viral transcription (GO:0019083)4.32573218
6translational termination (GO:0006415)4.14276630
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.05971759
8proteasome assembly (GO:0043248)4.04296377
9ribosomal small subunit biogenesis (GO:0042274)3.97322473
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.96446008
11cotranslational protein targeting to membrane (GO:0006613)3.95724702
12translational elongation (GO:0006414)3.92836264
13protein targeting to ER (GO:0045047)3.91583261
14maturation of SSU-rRNA (GO:0030490)3.85467182
15establishment of protein localization to mitochondrial membrane (GO:0090151)3.82370879
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.77600081
17deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.77024735
18chaperone-mediated protein transport (GO:0072321)3.73693705
19protein localization to endoplasmic reticulum (GO:0070972)3.73434735
20DNA strand elongation involved in DNA replication (GO:0006271)3.72122523
21sequestering of actin monomers (GO:0042989)3.71392769
22establishment of protein localization to endoplasmic reticulum (GO:0072599)3.67032905
23telomere maintenance via semi-conservative replication (GO:0032201)3.64798584
24L-phenylalanine metabolic process (GO:0006558)3.59649113
25erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.59649113
26metallo-sulfur cluster assembly (GO:0031163)3.53083073
27iron-sulfur cluster assembly (GO:0016226)3.53083073
28water-soluble vitamin biosynthetic process (GO:0042364)3.52710060
29respiratory electron transport chain (GO:0022904)3.52491122
30DNA strand elongation (GO:0022616)3.52432691
31L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.51139147
32formation of translation preinitiation complex (GO:0001731)3.50340235
33RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.48290472
34tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.48290472
35negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.47029594
36electron transport chain (GO:0022900)3.46487955
37pteridine-containing compound biosynthetic process (GO:0042559)3.44899487
38translational initiation (GO:0006413)3.40772702
39translation (GO:0006412)3.35925667
40ATP synthesis coupled proton transport (GO:0015986)3.32998171
41energy coupled proton transport, down electrochemical gradient (GO:0015985)3.32998171
42cellular protein complex disassembly (GO:0043624)3.32906400
43antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.29976325
44viral life cycle (GO:0019058)3.29339179
45negative regulation of ligase activity (GO:0051352)3.28933517
46negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.28933517
47erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.28866638
48L-phenylalanine catabolic process (GO:0006559)3.28866638
49rRNA modification (GO:0000154)3.28610615
50protein neddylation (GO:0045116)3.28288280
51DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.26335390
52regulation of cellular amino acid metabolic process (GO:0006521)3.24349697
53base-excision repair, AP site formation (GO:0006285)3.23547637
54pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.21623526
55L-methionine biosynthetic process (GO:0071265)3.20989497
56amino acid salvage (GO:0043102)3.20989497
57L-methionine salvage (GO:0071267)3.20989497
58nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.18893760
59signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.18663416
60intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.18663416
61signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.17550862
62signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.17550862
63signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.17550862
64mitochondrial respiratory chain complex I assembly (GO:0032981)3.16326803
65NADH dehydrogenase complex assembly (GO:0010257)3.16326803
66mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.16326803
67GTP biosynthetic process (GO:0006183)3.15947564
68positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.10690138
69regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.10485202
70termination of RNA polymerase III transcription (GO:0006386)3.10319923
71transcription elongation from RNA polymerase III promoter (GO:0006385)3.10319923
72protein targeting to mitochondrion (GO:0006626)3.09543390
73antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.07300759
74pseudouridine synthesis (GO:0001522)3.07143755
75signal transduction involved in DNA integrity checkpoint (GO:0072401)3.00831503
76signal transduction involved in DNA damage checkpoint (GO:0072422)3.00831503
77protein complex disassembly (GO:0043241)3.00092107
78regulation of metalloenzyme activity (GO:0048552)2.99776376
79UTP biosynthetic process (GO:0006228)2.99434188
80anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.98509490
81regulation of oxidative phosphorylation (GO:0002082)2.98380490
82signal transduction involved in cell cycle checkpoint (GO:0072395)2.97069075
83protein deneddylation (GO:0000338)2.95631591
84guanosine-containing compound biosynthetic process (GO:1901070)2.95146633
85platelet dense granule organization (GO:0060155)2.94567336
86telomere maintenance via recombination (GO:0000722)2.89025763
87oxidative phosphorylation (GO:0006119)2.87462253
88mitochondrial respiratory chain complex assembly (GO:0033108)2.87075900
89inner mitochondrial membrane organization (GO:0007007)2.86764400
90macromolecular complex disassembly (GO:0032984)2.86675257
91establishment of protein localization to mitochondrion (GO:0072655)2.86334548
92ribosomal large subunit biogenesis (GO:0042273)2.85780258
93protein complex biogenesis (GO:0070271)2.84697962
94mannosylation (GO:0097502)2.83342622
95ribonucleoprotein complex biogenesis (GO:0022613)2.82097414
96UTP metabolic process (GO:0046051)2.81260870
97replication fork processing (GO:0031297)2.81222059
98DNA replication initiation (GO:0006270)2.81186555
99cullin deneddylation (GO:0010388)2.81131236
100protein localization to mitochondrion (GO:0070585)2.79849992
101exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.79689897
102folic acid-containing compound biosynthetic process (GO:0009396)2.79500039
103peptidyl-histidine modification (GO:0018202)2.79497493
104binding of sperm to zona pellucida (GO:0007339)2.78507444
105rRNA processing (GO:0006364)2.77504232
106L-serine metabolic process (GO:0006563)2.75897516
107protein maturation by protein folding (GO:0022417)2.75523006
108pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.75161100
109nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.74397582
110pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.73983361
111telomere maintenance via telomere lengthening (GO:0010833)2.73210634
112sperm-egg recognition (GO:0035036)2.72917065
113cellular component biogenesis (GO:0044085)2.72568407
114chromatin remodeling at centromere (GO:0031055)2.71100443
115CENP-A containing nucleosome assembly (GO:0034080)2.70044545
116GDP-mannose metabolic process (GO:0019673)2.69444186
117pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.67444622
118lactate metabolic process (GO:0006089)2.67166654
119peroxisome fission (GO:0016559)2.66588059
120branched-chain amino acid catabolic process (GO:0009083)2.66283843
121intracellular protein transmembrane import (GO:0044743)2.64195292
122rRNA metabolic process (GO:0016072)2.63176548
123positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.61903549
124CTP biosynthetic process (GO:0006241)2.61646103
125CTP metabolic process (GO:0046036)2.61646103
126signal peptide processing (GO:0006465)2.61544161
127deoxyribonucleotide catabolic process (GO:0009264)2.61399853
128nuclear-transcribed mRNA catabolic process (GO:0000956)2.61230788
129fusion of sperm to egg plasma membrane (GO:0007342)2.60381497
130rRNA methylation (GO:0031167)2.60283031
131positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.60108924
132glutathione derivative biosynthetic process (GO:1901687)2.59831040
133glutathione derivative metabolic process (GO:1901685)2.59831040
134methionine biosynthetic process (GO:0009086)2.59014801
135nucleoside salvage (GO:0043174)2.58993450
136respiratory chain complex IV assembly (GO:0008535)2.58900397
137positive regulation of ligase activity (GO:0051351)2.58198588
138xenobiotic catabolic process (GO:0042178)2.56149722
139positive regulation of cell cycle arrest (GO:0071158)2.55686184
140deoxyribose phosphate catabolic process (GO:0046386)2.55531755
141anterograde synaptic vesicle transport (GO:0048490)2.54354952
142response to misfolded protein (GO:0051788)2.54116881
143DNA replication checkpoint (GO:0000076)2.53479607
144proline biosynthetic process (GO:0006561)2.53414428
145mitotic recombination (GO:0006312)2.52940997
146GMP metabolic process (GO:0046037)2.52935529
147aldehyde catabolic process (GO:0046185)2.52869261
148pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.52736524
149mRNA catabolic process (GO:0006402)2.51887829
1507-methylguanosine mRNA capping (GO:0006370)2.51718018
151pyrimidine nucleotide catabolic process (GO:0006244)2.51616558
152protein targeting to membrane (GO:0006612)2.51594274
153dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.51550179
154pteridine-containing compound metabolic process (GO:0042558)2.51285785
155adenosine metabolic process (GO:0046085)2.48797150
156ubiquinone biosynthetic process (GO:0006744)2.47632467
157purine nucleotide salvage (GO:0032261)2.47555502
158purine nucleoside triphosphate biosynthetic process (GO:0009145)2.46309114

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.85178260
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.62683166
3E2F7_22180533_ChIP-Seq_HELA_Human3.57081281
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.48948454
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.45145151
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.33715011
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.32832411
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.15771559
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.08592185
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.06952369
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.98883672
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.97395993
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.84407646
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.66704736
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.50926320
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.40156895
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.27128825
18VDR_23849224_ChIP-Seq_CD4+_Human2.26464354
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.24621423
20XRN2_22483619_ChIP-Seq_HELA_Human2.22733122
21* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.20479672
22* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.19562279
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.15126558
24FOXP3_21729870_ChIP-Seq_TREG_Human2.11419575
25* DCP1A_22483619_ChIP-Seq_HELA_Human2.09741294
26MYC_19079543_ChIP-ChIP_MESCs_Mouse2.07951816
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.00690006
28* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.00203029
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.95273028
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.92040389
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.91957283
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.91223671
33* GABP_19822575_ChIP-Seq_HepG2_Human1.91018101
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.87601654
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.85105753
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.78608583
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.76289083
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.72484476
39CIITA_25753668_ChIP-Seq_RAJI_Human1.71930546
40ERG_20887958_ChIP-Seq_HPC-7_Mouse1.68142704
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.65651935
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.64840257
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.63861044
44SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.62376559
45CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.60882266
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59692089
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.56105691
48E2F4_17652178_ChIP-ChIP_JURKAT_Human1.55554045
49* TTF2_22483619_ChIP-Seq_HELA_Human1.47425815
50VDR_21846776_ChIP-Seq_THP-1_Human1.47070307
51MYC_18940864_ChIP-ChIP_HL60_Human1.47064151
52CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.45946484
53HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.42600537
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42414958
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41324753
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39594406
57IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.38463017
58CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.37181869
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.35751549
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30892760
61MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29928001
62SPI1_23547873_ChIP-Seq_NB4_Human1.29134109
63* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27667231
64* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27193258
65PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.26867721
66ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.25774193
67FOXM1_23109430_ChIP-Seq_U2OS_Human1.23018250
68* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.22064018
69MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.21590900
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21297996
71GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20746620
72ELK1_19687146_ChIP-ChIP_HELA_Human1.19710468
73MYC_22102868_ChIP-Seq_BL_Human1.19442041
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.18616980
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17954734
76GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.16462846
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15801553
78YY1_22570637_ChIP-Seq_MALME-3M_Human1.15279382
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12581629
80STAT4_19710469_ChIP-ChIP_TH1__Mouse1.12413771
81AR_21909140_ChIP-Seq_LNCAP_Human1.11670580
82MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.11096812
83CTCF_26484167_Chip-Seq_Bcells_Mouse1.11070632
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09664066
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09106455
86IRF1_19129219_ChIP-ChIP_H3396_Human1.08060001
87HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07066011
88PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06997036
89EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04897207
90SCL_19346495_ChIP-Seq_HPC-7_Human1.04437751
91NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03858063
92E2F1_21310950_ChIP-Seq_MCF-7_Human1.03662411
93KDM5A_27292631_Chip-Seq_BREAST_Human1.03118059
94* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.03107684
95YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02973616
96CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01553778
97TFEB_21752829_ChIP-Seq_HELA_Human1.00525155
98* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.00499973
99NANOG_18555785_ChIP-Seq_MESCs_Mouse1.00070593
100ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.99816762
101POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99730193
102ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99691221
103RUNX1_22412390_ChIP-Seq_EML_Mouse0.98889929
104CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98639613
105IGF1R_20145208_ChIP-Seq_DFB_Human0.98032160
106ZNF274_21170338_ChIP-Seq_K562_Hela0.97839671
107BCL6_27268052_Chip-Seq_Bcells_Human0.97375926
108IRF8_22096565_ChIP-ChIP_GC-B_Human0.96722702
109CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96638212
110FOXP1_21924763_ChIP-Seq_HESCs_Human0.96320392
111RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.96158207
112* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95766950
113MYB_21317192_ChIP-Seq_ERMYB_Mouse0.95738843
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94384939
115SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94331120
116KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93823599
117EOMES_21245162_ChIP-Seq_HESCs_Human0.92432410
118CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.92398184
119DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92359904
120SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91684529
121* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91625108
122PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91025942
123TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.89169436
124ELK1_22589737_ChIP-Seq_MCF10A_Human0.88533869
125SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.85121085
126MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.84283203
127TP53_22573176_ChIP-Seq_HFKS_Human0.81572177
128ZNF263_19887448_ChIP-Seq_K562_Human0.79481244
129SOX17_20123909_ChIP-Seq_XEN_Mouse0.78828299
130TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78411360
131ERA_21632823_ChIP-Seq_H3396_Human0.75750469
132HTT_18923047_ChIP-ChIP_STHdh_Human0.71533535
133NANOG_16153702_ChIP-ChIP_HESCs_Human0.71307977
134SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.71211091
135NANOG_20526341_ChIP-Seq_ESCs_Human0.70803648
136ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.70456295

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.07252952
2MP0003693_abnormal_embryo_hatching3.97708483
3MP0005410_abnormal_fertilization3.34848507
4MP0003806_abnormal_nucleotide_metabolis3.07182196
5MP0003763_abnormal_thymus_physiology2.97413168
6MP0008058_abnormal_DNA_repair2.96042237
7MP0009840_abnormal_foam_cell2.79240210
8MP0008007_abnormal_cellular_replicative2.77353133
9MP0003186_abnormal_redox_activity2.59904587
10MP0002396_abnormal_hematopoietic_system2.46176161
11MP0006054_spinal_hemorrhage2.42056154
12MP0001661_extended_life_span2.41941007
13MP0005075_abnormal_melanosome_morpholog2.40071206
14MP0010094_abnormal_chromosome_stability2.39353412
15MP0003077_abnormal_cell_cycle2.38778214
16MP0009333_abnormal_splenocyte_physiolog2.34606485
17MP0003111_abnormal_nucleus_morphology2.30680129
18MP0005174_abnormal_tail_pigmentation2.23509085
19MP0002163_abnormal_gland_morphology2.16915744
20MP0009379_abnormal_foot_pigmentation2.13243989
21MP0003123_paternal_imprinting2.11753865
22MP0002132_abnormal_respiratory_system2.08320025
23MP0009785_altered_susceptibility_to2.07880585
24MP0000015_abnormal_ear_pigmentation2.07553622
25MP0003718_maternal_effect2.05361907
26MP0004957_abnormal_blastocyst_morpholog2.03659064
27MP0005671_abnormal_response_to2.01550869
28MP0002736_abnormal_nociception_after1.97344257
29MP0005646_abnormal_pituitary_gland1.93895787
30MP0008789_abnormal_olfactory_epithelium1.93124828
31MP0003136_yellow_coat_color1.92553013
32MP0000372_irregular_coat_pigmentation1.88724992
33MP0001853_heart_inflammation1.88452080
34MP0003656_abnormal_erythrocyte_physiolo1.83463167
35MP0003786_premature_aging1.80710049
36MP0003122_maternal_imprinting1.79845505
37MP0000685_abnormal_immune_system1.78916831
38MP0004147_increased_porphyrin_level1.75368875
39MP0001835_abnormal_antigen_presentation1.73283947
40MP0006036_abnormal_mitochondrial_physio1.71321284
41MP0002160_abnormal_reproductive_system1.70873847
42MP0001905_abnormal_dopamine_level1.67098830
43MP0001529_abnormal_vocalization1.66952658
44MP0002398_abnormal_bone_marrow1.65795435
45MP0003436_decreased_susceptibility_to1.62683178
46MP0003011_delayed_dark_adaptation1.57971873
47MP0004133_heterotaxia1.57309803
48MP0010030_abnormal_orbit_morphology1.52292693
49MP0000689_abnormal_spleen_morphology1.49320324
50MP0002722_abnormal_immune_system1.49256348
51MP0006072_abnormal_retinal_apoptosis1.48948551
52MP0005379_endocrine/exocrine_gland_phen1.48036945
53MP0005025_abnormal_response_to1.48023386
54MP0006292_abnormal_olfactory_placode1.47594975
55MP0002405_respiratory_system_inflammati1.47177062
56MP0001929_abnormal_gametogenesis1.45921796
57MP0008057_abnormal_DNA_replication1.44953641
58MP0005360_urolithiasis1.44710196
59MP0001545_abnormal_hematopoietic_system1.43568229
60MP0005397_hematopoietic_system_phenotyp1.43568229
61MP0002420_abnormal_adaptive_immunity1.43054060
62MP0001764_abnormal_homeostasis1.42326419
63MP0002429_abnormal_blood_cell1.42319399
64MP0000716_abnormal_immune_system1.42032926
65MP0000343_altered_response_to1.41798561
66MP0008775_abnormal_heart_ventricle1.41227833
67MP0001819_abnormal_immune_cell1.38864944
68MP0008995_early_reproductive_senescence1.38806167
69MP0001984_abnormal_olfaction1.38687622
70MP0002723_abnormal_immune_serum1.31139408
71MP0005499_abnormal_olfactory_system1.29114547
72MP0005394_taste/olfaction_phenotype1.29114547
73MP0000490_abnormal_crypts_of1.28817722
74MP0000703_abnormal_thymus_morphology1.27897156
75MP0005451_abnormal_body_composition1.27577853
76MP0000313_abnormal_cell_death1.27376430
77MP0002095_abnormal_skin_pigmentation1.25985443
78MP0003172_abnormal_lysosome_physiology1.25622392
79MP0010386_abnormal_urinary_bladder1.25275556
80MP0008932_abnormal_embryonic_tissue1.24489031
81MP0002019_abnormal_tumor_incidence1.24017591
82MP0005000_abnormal_immune_tolerance1.23576410
83MP0003121_genomic_imprinting1.22929422
84MP0001800_abnormal_humoral_immune1.21616257
85MP0008875_abnormal_xenobiotic_pharmacok1.21487207
86MP0002653_abnormal_ependyma_morphology1.18642863
87MP0002452_abnormal_antigen_presenting1.18327300
88MP0002233_abnormal_nose_morphology1.18186650
89MP0003279_aneurysm1.16417011
90MP0001968_abnormal_touch/_nociception1.16406418
91MP0008877_abnormal_DNA_methylation1.15871695
92MP0002234_abnormal_pharynx_morphology1.15763379
93MP0003195_calcinosis1.14661984
94MP0003315_abnormal_perineum_morphology1.13570302
95MP0004808_abnormal_hematopoietic_stem1.13460547
96MP0008872_abnormal_physiological_respon1.12322638
97MP0009384_cardiac_valve_regurgitation1.11574997
98MP0003698_abnormal_male_reproductive1.11170447
99MP0002938_white_spotting1.09824171
100MP0000858_altered_metastatic_potential1.07939659
101MP0002148_abnormal_hypersensitivity_rea1.06386497
102MP0005551_abnormal_eye_electrophysiolog1.05413368
103MP0004381_abnormal_hair_follicle1.05341251
104MP0002933_joint_inflammation1.04850098
105MP0002419_abnormal_innate_immunity1.03369123
106MP0005670_abnormal_white_adipose1.02193410
107MP0003724_increased_susceptibility_to1.02019311
108MP0005253_abnormal_eye_physiology1.00574390
109MP0000358_abnormal_cell_content/1.00477545
110MP0001756_abnormal_urination1.00040216
111MP0003890_abnormal_embryonic-extraembry0.98358023
112MP0002876_abnormal_thyroid_physiology0.97839398
113MP0005464_abnormal_platelet_physiology0.97366942
114MP0005220_abnormal_exocrine_pancreas0.96915948
115MP0005408_hypopigmentation0.95908273
116MP0000516_abnormal_urinary_system0.95702311
117MP0005367_renal/urinary_system_phenotyp0.95702311
118MP0000537_abnormal_urethra_morphology0.95009824
119MP0003937_abnormal_limbs/digits/tail_de0.92892187
120MP0008469_abnormal_protein_level0.92853886
121MP0000465_gastrointestinal_hemorrhage0.92510057
122MP0002090_abnormal_vision0.92250975
123MP0000653_abnormal_sex_gland0.91830874
124MP0003191_abnormal_cellular_cholesterol0.90322121
125MP0009697_abnormal_copulation0.89797533
126MP0001730_embryonic_growth_arrest0.88834536
127MP0000631_abnormal_neuroendocrine_gland0.88675107
128MP0002210_abnormal_sex_determination0.88385857
129MP0005636_abnormal_mineral_homeostasis0.87436201
130MP0001145_abnormal_male_reproductive0.86492298
131MP0000647_abnormal_sebaceous_gland0.85571035
132MP0001845_abnormal_inflammatory_respons0.84829474
133MP0001944_abnormal_pancreas_morphology0.84478241
134MP0005389_reproductive_system_phenotype0.84102107
135MP0010155_abnormal_intestine_physiology0.83716428
136MP0000749_muscle_degeneration0.82753250
137MP0004019_abnormal_vitamin_homeostasis0.82513229
138MP0000049_abnormal_middle_ear0.81667669
139MP0001542_abnormal_bone_strength0.80987152
140MP0003942_abnormal_urinary_system0.79991469
141MP0005332_abnormal_amino_acid0.79226702
142MP0009046_muscle_twitch0.78784894
143MP0003866_abnormal_defecation0.78668631
144MP0005058_abnormal_lysosome_morphology0.78651861
145MP0002102_abnormal_ear_morphology0.78380673
146MP0006276_abnormal_autonomic_nervous0.78321995
147MP0009643_abnormal_urine_homeostasis0.77546963
148MP0000350_abnormal_cell_proliferation0.77341808
149MP0005387_immune_system_phenotype0.76911099
150MP0001790_abnormal_immune_system0.76911099
151MP0005319_abnormal_enzyme/_coenzyme0.76646767
152MP0001293_anophthalmia0.76573894
153MP0005171_absent_coat_pigmentation0.76357506
154MP0004043_abnormal_pH_regulation0.76235121
155MP0004215_abnormal_myocardial_fiber0.76023000
156MP0001533_abnormal_skeleton_physiology0.70842990
157MP0003646_muscle_fatigue0.70511554
158MP0001873_stomach_inflammation0.68885774
159MP0001666_abnormal_nutrient_absorption0.68849597
160MP0005584_abnormal_enzyme/coenzyme_acti0.68456165
161MP0002638_abnormal_pupillary_reflex0.68087615
162MP0002089_abnormal_postnatal_growth/wei0.66686992
163MP0000538_abnormal_urinary_bladder0.66673957
164MP0006035_abnormal_mitochondrial_morpho0.66652940
165MP0005365_abnormal_bile_salt0.65443951
166MP0000747_muscle_weakness0.62495990
167MP0002295_abnormal_pulmonary_circulatio0.62257360

Predicted human phenotypes

RankGene SetZ-score
1Type I transferrin isoform profile (HP:0003642)4.17659998
2Reduced antithrombin III activity (HP:0001976)4.08678197
3Hyperglycinemia (HP:0002154)4.08247074
4Hepatocellular necrosis (HP:0001404)3.97808858
5Thrombocytosis (HP:0001894)3.95193719
6Abnormal number of erythroid precursors (HP:0012131)3.93204898
7Abnormality of cells of the erythroid lineage (HP:0012130)3.91436296
8Hepatic necrosis (HP:0002605)3.84700736
9Abnormal protein glycosylation (HP:0012346)3.66294003
10Abnormal glycosylation (HP:0012345)3.66294003
11Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.66294003
12Abnormal protein N-linked glycosylation (HP:0012347)3.66294003
13Decreased activity of mitochondrial respiratory chain (HP:0008972)3.62865398
14Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.62865398
15Reticulocytopenia (HP:0001896)3.50951965
16Abnormal mitochondria in muscle tissue (HP:0008316)3.30306179
17Cutaneous melanoma (HP:0012056)3.24807778
18Aplastic anemia (HP:0001915)3.24182646
19Mitochondrial inheritance (HP:0001427)3.23002163
20Acute necrotizing encephalopathy (HP:0006965)3.18218443
21Abnormality of aromatic amino acid family metabolism (HP:0004338)3.05865634
22Hyperinsulinemic hypoglycemia (HP:0000825)3.05792188
23Hypoglycemic coma (HP:0001325)3.01262067
24Increased CSF lactate (HP:0002490)2.96878962
25Increased intramyocellular lipid droplets (HP:0012240)2.93339033
26Increased muscle lipid content (HP:0009058)2.92005160
27Methylmalonic aciduria (HP:0012120)2.89071590
28IgM deficiency (HP:0002850)2.85554518
29Increased serum lactate (HP:0002151)2.79435451
30Aplasia/Hypoplasia of the sacrum (HP:0008517)2.75909998
31Abnormality of the heme biosynthetic pathway (HP:0010472)2.74641305
32Acute encephalopathy (HP:0006846)2.72834330
33Hypoglycemic seizures (HP:0002173)2.72826865
34Generalized aminoaciduria (HP:0002909)2.71501991
35Methylmalonic acidemia (HP:0002912)2.70477513
36Exertional dyspnea (HP:0002875)2.65531420
37Elevated erythrocyte sedimentation rate (HP:0003565)2.65481271
38Respiratory difficulties (HP:0002880)2.64174515
39Lipid accumulation in hepatocytes (HP:0006561)2.61872264
40Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.60194854
41Abnormality of serum amino acid levels (HP:0003112)2.59584099
42Increased hepatocellular lipid droplets (HP:0006565)2.57281717
43Ketosis (HP:0001946)2.56822148
44Renal Fanconi syndrome (HP:0001994)2.55800154
45Recurrent bronchitis (HP:0002837)2.52097672
46Lethargy (HP:0001254)2.51049493
4711 pairs of ribs (HP:0000878)2.49179219
48Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.46874562
49Abnormal spermatogenesis (HP:0008669)2.45359881
50Degeneration of anterior horn cells (HP:0002398)2.40865818
51Abnormality of the anterior horn cell (HP:0006802)2.40865818
52Ketoacidosis (HP:0001993)2.39597689
53Abnormality of serine family amino acid metabolism (HP:0010894)2.39322480
54Abnormality of glycine metabolism (HP:0010895)2.39322480
55Exercise intolerance (HP:0003546)2.36178950
56Lactic acidosis (HP:0003128)2.36062796
57Macrocytic anemia (HP:0001972)2.35722055
58Cerebral hypomyelination (HP:0006808)2.35522820
593-Methylglutaconic aciduria (HP:0003535)2.35242773
60Pallor (HP:0000980)2.34857808
61Poor head control (HP:0002421)2.31222088
62Chronic otitis media (HP:0000389)2.29652445
63Microretrognathia (HP:0000308)2.29480151
64Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.29163578
65Pancytopenia (HP:0001876)2.20890399
66Bronchitis (HP:0012387)2.20862896
67Beaking of vertebral bodies (HP:0004568)2.20626729
68Nasal polyposis (HP:0100582)2.20590531
69Oral leukoplakia (HP:0002745)2.19291892
70True hermaphroditism (HP:0010459)2.18982365
71Pancreatic fibrosis (HP:0100732)2.16580945
72Progressive macrocephaly (HP:0004481)2.13959330
73Glycosuria (HP:0003076)2.10449891
74Abnormality of urine glucose concentration (HP:0011016)2.10449891
75Abnormality of the nasal mucosa (HP:0000433)2.07066696
76Microvesicular hepatic steatosis (HP:0001414)2.02777648
77Selective tooth agenesis (HP:0001592)2.01706023
78Abnormality of T cell physiology (HP:0011840)2.00704589
79Petechiae (HP:0000967)2.00207244
80Rhinitis (HP:0012384)1.97629187
81Respiratory failure (HP:0002878)1.97477490
82Optic disc pallor (HP:0000543)1.97359919
83Pancreatic cysts (HP:0001737)1.96071769
84Type 2 muscle fiber atrophy (HP:0003554)1.95446680
85Abnormality of methionine metabolism (HP:0010901)1.94896496
86Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.94555216
87Metabolic acidosis (HP:0001942)1.94328324
88Pancreatic islet-cell hyperplasia (HP:0004510)1.93336209
89CNS demyelination (HP:0007305)1.93199958
90Carpal bone hypoplasia (HP:0001498)1.92193741
91Aplasia/hypoplasia of the uterus (HP:0008684)1.91475206
92Abnormal respiratory epithelium morphology (HP:0012253)1.89030038
93Abnormal respiratory motile cilium morphology (HP:0005938)1.89030038
94Rough bone trabeculation (HP:0100670)1.87773169
95Myositis (HP:0100614)1.86767602
96Tubulointerstitial nephritis (HP:0001970)1.86083581
97Symptomatic seizures (HP:0011145)1.85601465
98Sclerocornea (HP:0000647)1.85570309
99Abnormality of renal resorption (HP:0011038)1.85248223
100Cerebral edema (HP:0002181)1.84203772
101Abnormality of the pancreatic islet cells (HP:0006476)1.83909671
102Abnormality of endocrine pancreas physiology (HP:0012093)1.83909671
103Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83852586
104Abnormality of alanine metabolism (HP:0010916)1.83852586
105Hyperalaninemia (HP:0003348)1.83852586
106Enlarged kidneys (HP:0000105)1.83801506
107Neutropenia (HP:0001875)1.82214242
108Myoglobinuria (HP:0002913)1.81839368
109Absent rod-and cone-mediated responses on ERG (HP:0007688)1.81769204
110Hyperthyroidism (HP:0000836)1.81749641
111Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.81730208
112Redundant skin (HP:0001582)1.80265438
113Dicarboxylic aciduria (HP:0003215)1.79838063
114Abnormality of dicarboxylic acid metabolism (HP:0010995)1.79838063
115Abnormality of vitamin B metabolism (HP:0004340)1.78556453
116Rhabdomyolysis (HP:0003201)1.78442727
117Albinism (HP:0001022)1.78357619
118Nonimmune hydrops fetalis (HP:0001790)1.77984086
119Late onset (HP:0003584)1.77650819
120IgG deficiency (HP:0004315)1.77511410
121Spontaneous hematomas (HP:0007420)1.77200996
122Breast hypoplasia (HP:0003187)1.77003775
123Prominent metopic ridge (HP:0005487)1.76935176
124Muscle fiber atrophy (HP:0100295)1.76308798
125Opisthotonus (HP:0002179)1.76081159
126Abnormal respiratory motile cilium physiology (HP:0012261)1.75961015
127Medial flaring of the eyebrow (HP:0010747)1.75451553
128Neoplasm of the adrenal gland (HP:0100631)1.74789580
129Absent thumb (HP:0009777)1.74101118
130Chronic bronchitis (HP:0004469)1.74010731
131Hypokinesia (HP:0002375)1.73870140
132Severe visual impairment (HP:0001141)1.73762263
133Chromosomal breakage induced by crosslinking agents (HP:0003221)1.73147841
134Hypoplasia of the uterus (HP:0000013)1.73115113
135Abnormality of glycolysis (HP:0004366)1.72829017
136Increased serum pyruvate (HP:0003542)1.72829017
137Abnormality of fatty-acid metabolism (HP:0004359)1.72404099
138Irregular epiphyses (HP:0010582)1.72163049
139Leukodystrophy (HP:0002415)1.72126104
140Colon cancer (HP:0003003)1.71881071
141Hypoplasia of the capital femoral epiphysis (HP:0003090)1.71710334
142Emotional lability (HP:0000712)1.70427824
143Nephrogenic diabetes insipidus (HP:0009806)1.70211367
144Abnormality of T cells (HP:0002843)1.69993870
145Abnormal biliary tract physiology (HP:0012439)1.69668445
146Bile duct proliferation (HP:0001408)1.69668445
147Hepatosplenomegaly (HP:0001433)1.68814761
148Hyperglycinuria (HP:0003108)1.67997116
149Occipital encephalocele (HP:0002085)1.67986354
150Meningioma (HP:0002858)1.67731648
151Secondary amenorrhea (HP:0000869)1.67242831
152Gout (HP:0001997)1.66835176
153Male pseudohermaphroditism (HP:0000037)1.65961365
154Hyperammonemia (HP:0001987)1.65446533

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.77588040
2VRK23.75762846
3BUB13.43409061
4EIF2AK13.36459069
5NME23.15989197
6TESK13.10697400
7FRK2.90558689
8PINK12.80453134
9MAP4K12.59614372
10BCKDK2.29554451
11PIM22.24563999
12VRK12.10450671
13TESK22.00894534
14MAP4K21.98638540
15WEE11.98487487
16EIF2AK31.98240535
17CSNK1G31.95288962
18MAP2K31.89260062
19ZAP701.84546086
20KDR1.84351401
21SRPK11.78064556
22CSNK1G11.75853779
23TXK1.75098386
24MAP2K61.70696236
25TGFBR11.69430778
26CSNK1A1L1.68446157
27PDK41.62483106
28PDK31.62483106
29BTK1.61964447
30CDC71.59477025
31LIMK11.57937592
32PHKG21.56330518
33PHKG11.56330518
34MAP2K71.55790781
35LMTK21.50320771
36TLK11.47163764
37CSNK1G21.45994493
38PLK31.45195977
39TNIK1.42280606
40TEC1.38971478
41NLK1.34547790
42NEK21.34062481
43PASK1.33582992
44TRIM281.29141295
45MAP3K121.28719233
46TTK1.27063599
47DYRK21.23957570
48ACVR1B1.17938692
49CDK81.17495595
50TYK21.16956518
51BRSK21.15573675
52FGFR21.15365803
53GRK11.13104553
54IRAK41.13027550
55PRPF4B1.12590150
56MYLK1.11463799
57ABL21.11016615
58FLT31.07331523
59ERN11.01036424
60WNK31.00567283
61DYRK30.99779583
62LRRK20.99507562
63RPS6KA40.98635208
64BRSK10.98612049
65CLK10.97056743
66MAP3K30.96438069
67ZAK0.95801137
68MAPKAPK30.95517100
69NUAK10.94132822
70MUSK0.92951412
71RPS6KB20.92102444
72PAK40.91415409
73ILK0.90998255
74RPS6KA50.88964084
75KIT0.86913493
76NME10.85423346
77CDK70.85368081
78BMPR1B0.84427340
79EPHA20.84404704
80JAK30.84375294
81MKNK10.82696475
82YES10.82175431
83TBK10.81934184
84AURKB0.81355700
85INSRR0.80333571
86MARK30.79283146
87EPHB20.78339383
88TAOK20.78292325
89AURKA0.74305199
90ATR0.74285056
91CCNB10.72551649
92CHEK20.72214266
93SCYL20.72068533
94TRIB30.71527630
95PLK10.69979276
96PRKCI0.69859080
97ADRBK20.69577505
98STK38L0.67003906
99CSF1R0.66042052
100PAK10.65900284
101STK240.64957287
102SYK0.64802316
103PLK40.64265185
104LCK0.60797011
105STK390.58781330
106GRK60.57857552
107BRAF0.57779500
108CSNK1A10.55541418
109MAP3K110.53353849
110LYN0.52633669
111STK100.52435978
112EPHA40.51435411
113ARAF0.51199213
114NEK10.50917410
115PLK20.50691534
116CSNK2A10.50649426
117WNK40.50280301
118AKT20.50113584
119EPHB10.50108287
120EIF2AK20.49939210
121MAPK40.49650401
122CAMK2G0.49300276
123IKBKE0.48123720
124ATM0.46983766
125PKN10.46259017
126OXSR10.45676489
127MAP3K40.45573453
128PDK20.45533704
129DAPK30.42149962
130CDK190.41465745
131MST40.41192687
132DAPK10.40499510
133CAMK2D0.40109563
134CDK30.40004849
135IRAK10.39889320
136PBK0.39453317
137MAP2K20.39289919
138PRKCE0.37666154
139ERBB30.37000333
140PIM10.36743712
141TSSK60.35910804
142OBSCN0.35576753
143CSNK2A20.34356862
144TNK20.33704174
145FGFR40.33634499
146CDK90.32497411
147CSNK1E0.30933333
148ADRBK10.30694580
149STK30.29279663

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.16555671
2DNA replication_Homo sapiens_hsa030303.85641371
3Proteasome_Homo sapiens_hsa030503.60967036
4Base excision repair_Homo sapiens_hsa034103.10263429
5RNA polymerase_Homo sapiens_hsa030203.02581874
6Mismatch repair_Homo sapiens_hsa034302.73569971
7Pyrimidine metabolism_Homo sapiens_hsa002402.50914520
8Protein export_Homo sapiens_hsa030602.47865397
9Homologous recombination_Homo sapiens_hsa034402.20476057
10Spliceosome_Homo sapiens_hsa030402.09990039
11Sulfur relay system_Homo sapiens_hsa041221.84432792
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.82996809
13Nucleotide excision repair_Homo sapiens_hsa034201.82403773
14Pentose phosphate pathway_Homo sapiens_hsa000301.80547008
15Basal transcription factors_Homo sapiens_hsa030221.73706455
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.69586452
17Parkinsons disease_Homo sapiens_hsa050121.68876142
18RNA transport_Homo sapiens_hsa030131.63224625
19Oxidative phosphorylation_Homo sapiens_hsa001901.61800733
20Drug metabolism - other enzymes_Homo sapiens_hsa009831.61096930
21Butanoate metabolism_Homo sapiens_hsa006501.60823185
22Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.58852608
23Non-homologous end-joining_Homo sapiens_hsa034501.56519485
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55281807
25One carbon pool by folate_Homo sapiens_hsa006701.55074168
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.54185994
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47002655
28Purine metabolism_Homo sapiens_hsa002301.40669365
29Huntingtons disease_Homo sapiens_hsa050161.39243283
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.38104376
31Folate biosynthesis_Homo sapiens_hsa007901.31611058
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31296223
33RNA degradation_Homo sapiens_hsa030181.29272691
34Primary immunodeficiency_Homo sapiens_hsa053401.22498467
35N-Glycan biosynthesis_Homo sapiens_hsa005101.20985247
36Cell cycle_Homo sapiens_hsa041101.20700703
37Glutathione metabolism_Homo sapiens_hsa004801.19972698
38Selenocompound metabolism_Homo sapiens_hsa004501.09763450
39Fanconi anemia pathway_Homo sapiens_hsa034601.09154404
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08059883
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.07216299
42Fatty acid elongation_Homo sapiens_hsa000621.06426320
43Antigen processing and presentation_Homo sapiens_hsa046121.06259334
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.02237913
45Pyruvate metabolism_Homo sapiens_hsa006201.00970566
46Carbon metabolism_Homo sapiens_hsa012000.99819487
47Collecting duct acid secretion_Homo sapiens_hsa049660.99769066
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.97287220
49Cardiac muscle contraction_Homo sapiens_hsa042600.96148114
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91422845
51Biosynthesis of amino acids_Homo sapiens_hsa012300.90732998
52Alzheimers disease_Homo sapiens_hsa050100.90333117
53Vitamin B6 metabolism_Homo sapiens_hsa007500.88271939
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87355542
55Fatty acid degradation_Homo sapiens_hsa000710.86892394
56p53 signaling pathway_Homo sapiens_hsa041150.86663245
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85044931
58Arginine biosynthesis_Homo sapiens_hsa002200.85038189
59Tyrosine metabolism_Homo sapiens_hsa003500.83811400
60Other glycan degradation_Homo sapiens_hsa005110.82404497
61Peroxisome_Homo sapiens_hsa041460.82304806
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81430992
63Steroid biosynthesis_Homo sapiens_hsa001000.81387989
64Tryptophan metabolism_Homo sapiens_hsa003800.80480936
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79106068
66Phenylalanine metabolism_Homo sapiens_hsa003600.78986226
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78686098
68Arachidonic acid metabolism_Homo sapiens_hsa005900.78670717
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77457801
70Epstein-Barr virus infection_Homo sapiens_hsa051690.77310968
71Metabolic pathways_Homo sapiens_hsa011000.76052092
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75628470
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75364134
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75112086
75Propanoate metabolism_Homo sapiens_hsa006400.72764710
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.71924057
77Fructose and mannose metabolism_Homo sapiens_hsa000510.69815451
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65789793
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65525363
80Legionellosis_Homo sapiens_hsa051340.61554490
81Arginine and proline metabolism_Homo sapiens_hsa003300.61049853
82Galactose metabolism_Homo sapiens_hsa000520.59485823
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59229771
84Sulfur metabolism_Homo sapiens_hsa009200.58982938
85Herpes simplex infection_Homo sapiens_hsa051680.57824030
86Caffeine metabolism_Homo sapiens_hsa002320.57653523
87Fat digestion and absorption_Homo sapiens_hsa049750.56682848
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.56496416
89Nitrogen metabolism_Homo sapiens_hsa009100.55231173
90Shigellosis_Homo sapiens_hsa051310.55109336
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54727123
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53035784
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.52974936
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52742831
95Vibrio cholerae infection_Homo sapiens_hsa051100.52311333
96Retinol metabolism_Homo sapiens_hsa008300.51221103
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50349747
98Fatty acid metabolism_Homo sapiens_hsa012120.50149666
99Linoleic acid metabolism_Homo sapiens_hsa005910.50048134
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49469234
101Measles_Homo sapiens_hsa051620.47106474
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46907941
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45575186
104Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44802494
105Chemical carcinogenesis_Homo sapiens_hsa052040.43893867
106Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43033512
107Hematopoietic cell lineage_Homo sapiens_hsa046400.42840918
108Vitamin digestion and absorption_Homo sapiens_hsa049770.42438132
109Regulation of autophagy_Homo sapiens_hsa041400.41259072
110Starch and sucrose metabolism_Homo sapiens_hsa005000.40398892
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39373318
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.39279292
113Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38557448
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.37500778
115Glycerolipid metabolism_Homo sapiens_hsa005610.37011567
116mRNA surveillance pathway_Homo sapiens_hsa030150.35783213
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35223064
1182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34840594
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33547278
120beta-Alanine metabolism_Homo sapiens_hsa004100.31577675
121Renin-angiotensin system_Homo sapiens_hsa046140.30263768
122Systemic lupus erythematosus_Homo sapiens_hsa053220.29377598
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.27267607
124Sphingolipid metabolism_Homo sapiens_hsa006000.26827824
125Apoptosis_Homo sapiens_hsa042100.26308131
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26164014

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