ZCCHC8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.14742716
2protein localization to chromosome, centromeric region (GO:0071459)4.59192207
3DNA strand elongation involved in DNA replication (GO:0006271)4.51248368
4DNA unwinding involved in DNA replication (GO:0006268)4.48599515
5mitotic chromosome condensation (GO:0007076)4.47965243
6mitotic metaphase plate congression (GO:0007080)4.45776161
7DNA strand elongation (GO:0022616)4.31543042
8telomere maintenance via semi-conservative replication (GO:0032201)4.28980735
9kinetochore organization (GO:0051383)4.17362893
10mitotic sister chromatid segregation (GO:0000070)4.17291760
11DNA replication checkpoint (GO:0000076)4.14550106
12mitotic nuclear envelope disassembly (GO:0007077)4.14395382
13metaphase plate congression (GO:0051310)4.10756546
14DNA replication initiation (GO:0006270)4.08468935
15telomere maintenance via recombination (GO:0000722)4.01329585
16behavioral response to nicotine (GO:0035095)4.00833344
17sister chromatid segregation (GO:0000819)3.95505357
18mitotic recombination (GO:0006312)3.94051956
19chromatin remodeling at centromere (GO:0031055)3.93142740
20fucose catabolic process (GO:0019317)3.91841742
21L-fucose metabolic process (GO:0042354)3.91841742
22L-fucose catabolic process (GO:0042355)3.91841742
23CENP-A containing nucleosome assembly (GO:0034080)3.91653592
24establishment of chromosome localization (GO:0051303)3.91148941
25negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.85342103
26negative regulation of translation, ncRNA-mediated (GO:0040033)3.85342103
27regulation of translation, ncRNA-mediated (GO:0045974)3.85342103
28nuclear envelope disassembly (GO:0051081)3.81153505
29membrane disassembly (GO:0030397)3.81153505
30attachment of spindle microtubules to kinetochore (GO:0008608)3.80733556
31kinetochore assembly (GO:0051382)3.75754853
32DNA replication-independent nucleosome organization (GO:0034724)3.74457980
33DNA replication-independent nucleosome assembly (GO:0006336)3.74457980
34nuclear pore organization (GO:0006999)3.70154828
35nuclear pore complex assembly (GO:0051292)3.69888698
36piRNA metabolic process (GO:0034587)3.64394873
37nucleotide-excision repair, DNA gap filling (GO:0006297)3.60689641
38mitotic sister chromatid cohesion (GO:0007064)3.58989260
39positive regulation of chromosome segregation (GO:0051984)3.58466730
40meiotic chromosome segregation (GO:0045132)3.57862011
41positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.56407273
42positive regulation of mitotic sister chromatid separation (GO:1901970)3.56407273
43positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.56407273
44protein localization to chromosome (GO:0034502)3.55440737
45telomere maintenance via telomere lengthening (GO:0010833)3.55233717
46regulation of sister chromatid cohesion (GO:0007063)3.55128920
47regulation of spindle organization (GO:0090224)3.53867612
48centriole replication (GO:0007099)3.50019372
49DNA duplex unwinding (GO:0032508)3.47320846
50DNA geometric change (GO:0032392)3.46831831
51rRNA catabolic process (GO:0016075)3.46757526
52DNA replication-dependent nucleosome assembly (GO:0006335)3.43388595
53DNA replication-dependent nucleosome organization (GO:0034723)3.43388595
54chromatin assembly or disassembly (GO:0006333)3.38256957
55histone exchange (GO:0043486)3.34881467
56chromosome segregation (GO:0007059)3.32763462
57histone H2A acetylation (GO:0043968)3.28675913
58regulation of chromosome segregation (GO:0051983)3.26503358
59regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.26025427
60ribosomal small subunit assembly (GO:0000028)3.24694087
61negative regulation of DNA-dependent DNA replication (GO:2000104)3.24646084
62recombinational repair (GO:0000725)3.22538090
63double-strand break repair via homologous recombination (GO:0000724)3.21228509
64mismatch repair (GO:0006298)3.20628930
65RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.20340534
66monoubiquitinated protein deubiquitination (GO:0035520)3.19415380
67regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.19407430
68spindle checkpoint (GO:0031577)3.19251032
69regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.18022500
70negative regulation of histone methylation (GO:0031061)3.17196564
71negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.15617364
72protein K6-linked ubiquitination (GO:0085020)3.15241952
73negative regulation of chromosome segregation (GO:0051985)3.14555679
74DNA conformation change (GO:0071103)3.14512262
75regulation of gene silencing by RNA (GO:0060966)3.13281503
76regulation of posttranscriptional gene silencing (GO:0060147)3.13281503
77regulation of gene silencing by miRNA (GO:0060964)3.13281503
78regulation of mitotic metaphase/anaphase transition (GO:0030071)3.12783657
79translesion synthesis (GO:0019985)3.11903759
80regulation of double-strand break repair via homologous recombination (GO:0010569)3.11770109
81regulation of nuclear cell cycle DNA replication (GO:0033262)3.11084103
82DNA deamination (GO:0045006)3.10694515
83nucleobase biosynthetic process (GO:0046112)3.09446586
84ATP-dependent chromatin remodeling (GO:0043044)3.08733666
85negative regulation of mitotic sister chromatid separation (GO:2000816)3.08718111
86negative regulation of mitotic sister chromatid segregation (GO:0033048)3.08718111
87negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.08718111
88negative regulation of sister chromatid segregation (GO:0033046)3.08718111
89somatic hypermutation of immunoglobulin genes (GO:0016446)3.07023862
90somatic diversification of immune receptors via somatic mutation (GO:0002566)3.07023862
91negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.06468885
92IMP biosynthetic process (GO:0006188)3.05472558
93spindle assembly checkpoint (GO:0071173)3.05364916
94DNA topological change (GO:0006265)3.05058499
95regulation of histone H3-K9 methylation (GO:0051570)3.01932574
96regulation of sister chromatid segregation (GO:0033045)3.00841855
97regulation of mitotic sister chromatid separation (GO:0010965)3.00841855
98regulation of mitotic sister chromatid segregation (GO:0033047)3.00841855
99mitotic spindle assembly checkpoint (GO:0007094)3.00780116
100chromosome condensation (GO:0030261)3.00606530
101telomere maintenance (GO:0000723)2.99564217
102pore complex assembly (GO:0046931)2.99485580
103detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.97902748
104regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.97478139
105regulation of mitotic spindle checkpoint (GO:1903504)2.97478139
106telomere organization (GO:0032200)2.97310228
107maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.96876393
108mitotic spindle checkpoint (GO:0071174)2.96510549
109epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.94185220
110regulation of mitotic spindle organization (GO:0060236)2.93996128
111folic acid-containing compound biosynthetic process (GO:0009396)2.93582403
112synapsis (GO:0007129)2.93259777
113viral mRNA export from host cell nucleus (GO:0046784)2.92976155
114reciprocal DNA recombination (GO:0035825)2.91514825
115reciprocal meiotic recombination (GO:0007131)2.91514825
116nuclear envelope organization (GO:0006998)2.91507211
117negative regulation of RNA splicing (GO:0033119)2.89622321
118DNA methylation involved in gamete generation (GO:0043046)2.89304297
119dosage compensation (GO:0007549)2.89089330
120neural tube formation (GO:0001841)2.86984870
121protein K11-linked deubiquitination (GO:0035871)2.86917686
122postreplication repair (GO:0006301)2.85727948
123base-excision repair (GO:0006284)2.84305141
124regulation of centriole replication (GO:0046599)2.81897126
125chromatin assembly (GO:0031497)2.81725951
126histone H2A monoubiquitination (GO:0035518)2.81350135
127DNA synthesis involved in DNA repair (GO:0000731)2.80446983
128kynurenine metabolic process (GO:0070189)2.80304134
129regulation of centrosome cycle (GO:0046605)2.80041429
130DNA packaging (GO:0006323)2.79960077
131replication fork processing (GO:0031297)2.78239507
132maturation of SSU-rRNA (GO:0030490)2.77830286
133tryptophan catabolic process (GO:0006569)2.75999614
134indole-containing compound catabolic process (GO:0042436)2.75999614
135indolalkylamine catabolic process (GO:0046218)2.75999614
136indolalkylamine metabolic process (GO:0006586)2.72179887
137regulation of DNA endoreduplication (GO:0032875)2.71275335
138male meiosis I (GO:0007141)2.71148215
139protein-cofactor linkage (GO:0018065)2.66349023
140protein K63-linked deubiquitination (GO:0070536)2.62951134
141gene silencing by RNA (GO:0031047)2.60300125
142response to pheromone (GO:0019236)2.59174440
143DNA double-strand break processing (GO:0000729)2.56836324
144somite rostral/caudal axis specification (GO:0032525)2.56738525
145epithelial cilium movement (GO:0003351)2.56413065
146positive regulation of mRNA catabolic process (GO:0061014)2.55930377
147histone H3-K9 methylation (GO:0051567)2.55509650
148intra-S DNA damage checkpoint (GO:0031573)2.55453911
149detection of light stimulus involved in sensory perception (GO:0050962)2.55295061
150detection of light stimulus involved in visual perception (GO:0050908)2.55295061
151exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.54603737
152regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.54197968
153positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.54197968
154regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.53382965
155male meiosis (GO:0007140)2.53307784
156negative regulation by host of viral transcription (GO:0043922)2.52332185
157snRNA transcription (GO:0009301)2.52189601
158histone-serine phosphorylation (GO:0035404)2.50452353
159nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.50181218
160respiratory chain complex IV assembly (GO:0008535)2.50030710
161regulation of meiosis I (GO:0060631)2.49749525
162pseudouridine synthesis (GO:0001522)2.49528064
163regulation of hippo signaling (GO:0035330)2.47770538
164mitotic cell cycle arrest (GO:0071850)2.46490022
165water-soluble vitamin biosynthetic process (GO:0042364)2.46330912
166positive regulation of histone H3-K4 methylation (GO:0051571)2.44569323
167regulation of centrosome duplication (GO:0010824)2.43806147
168protein K48-linked deubiquitination (GO:0071108)2.43520779
169interkinetic nuclear migration (GO:0022027)2.42743600
170tryptophan metabolic process (GO:0006568)2.40775484
171mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.39738313
172mitochondrial respiratory chain complex I assembly (GO:0032981)2.39738313
173NADH dehydrogenase complex assembly (GO:0010257)2.39738313
174negative regulation of telomere maintenance (GO:0032205)2.36248070
175preassembly of GPI anchor in ER membrane (GO:0016254)2.36202631
176positive regulation of mRNA metabolic process (GO:1903313)2.35939445
177positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.34877927
178regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.34877927
179positive regulation of mRNA processing (GO:0050685)2.31438525
180cellular ketone body metabolic process (GO:0046950)2.31268389
181S-adenosylmethionine metabolic process (GO:0046500)2.30481081
182DNA demethylation (GO:0080111)2.29876427
183prenylation (GO:0097354)2.29846589
184protein prenylation (GO:0018342)2.29846589
185positive regulation of mRNA 3-end processing (GO:0031442)2.27695044
186regulation of mesoderm development (GO:2000380)2.26979039
187nephron tubule morphogenesis (GO:0072078)2.26801063
188nephron epithelium morphogenesis (GO:0072088)2.26801063
189positive regulation of defense response to virus by host (GO:0002230)2.26527022
190protein polyglutamylation (GO:0018095)2.26247507

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.50325159
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.22457010
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.83853442
4ZNF274_21170338_ChIP-Seq_K562_Hela3.77599176
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.30258296
6VDR_22108803_ChIP-Seq_LS180_Human3.07861770
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.68905052
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.51696663
9EWS_26573619_Chip-Seq_HEK293_Human2.45415562
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.43661064
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.42307810
12* E2F1_21310950_ChIP-Seq_MCF-7_Human2.34948239
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.33354675
14MYC_22102868_ChIP-Seq_BL_Human2.32754519
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.31598809
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.31077301
17FUS_26573619_Chip-Seq_HEK293_Human2.30192977
18* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.29898449
19* EST1_17652178_ChIP-ChIP_JURKAT_Human2.28366269
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.21964381
21CIITA_25753668_ChIP-Seq_RAJI_Human2.18310561
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.15169164
23* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.11710800
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09280112
25* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08255758
26AR_21909140_ChIP-Seq_LNCAP_Human2.07238914
27TAF15_26573619_Chip-Seq_HEK293_Human2.06235767
28ER_23166858_ChIP-Seq_MCF-7_Human2.01927918
29ZFP57_27257070_Chip-Seq_ESCs_Mouse2.01679751
30IGF1R_20145208_ChIP-Seq_DFB_Human2.01557700
31E2F7_22180533_ChIP-Seq_HELA_Human10.2816178
32* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.96753695
33* ETS1_20019798_ChIP-Seq_JURKAT_Human1.92737478
34* XRN2_22483619_ChIP-Seq_HELA_Human1.92449519
35BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.87386188
36VDR_23849224_ChIP-Seq_CD4+_Human1.86958831
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.86302987
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.85901573
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.85523862
40IRF1_19129219_ChIP-ChIP_H3396_Human1.85068294
41FOXP3_21729870_ChIP-Seq_TREG_Human1.84667002
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.83950278
43GBX2_23144817_ChIP-Seq_PC3_Human1.81838046
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80595885
45GABP_17652178_ChIP-ChIP_JURKAT_Human1.79846577
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79443868
47JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.79088804
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76848727
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.76064399
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.74557880
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.73069846
52* HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.66806297
53DCP1A_22483619_ChIP-Seq_HELA_Human1.66589571
54P300_19829295_ChIP-Seq_ESCs_Human1.65123191
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65072876
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65045609
57* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64833123
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64037978
59GATA1_22025678_ChIP-Seq_K562_Human1.63275947
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.58753963
61KDM5A_27292631_Chip-Seq_BREAST_Human1.55696916
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.55123244
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55116152
64GABP_19822575_ChIP-Seq_HepG2_Human1.53095270
65* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52080618
66TTF2_22483619_ChIP-Seq_HELA_Human1.51109501
67* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.50935252
68* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.49836681
69TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.49172446
70VDR_21846776_ChIP-Seq_THP-1_Human1.44410995
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37325740
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36984958
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36873536
74ELK1_19687146_ChIP-ChIP_HELA_Human1.36045471
75* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.35495267
76TP53_22573176_ChIP-Seq_HFKS_Human1.34229815
77CBP_20019798_ChIP-Seq_JUKART_Human1.33930527
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33930527
79SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32593178
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32433328
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32337522
82CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31456853
83ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30633828
84RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29968501
85* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.28946707
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27587408
87POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27587408
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27383181
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26607443
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25609004
91IRF8_22096565_ChIP-ChIP_GC-B_Human1.25452995
92STAT3_23295773_ChIP-Seq_U87_Human1.24025998
93YY1_21170310_ChIP-Seq_MESCs_Mouse1.23674333
94ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19834499
95ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18065650
96PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17506783
97TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16940762
98SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.16908085
99SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16867303
100* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.16834053
101BCAT_22108803_ChIP-Seq_LS180_Human1.16610400
102GATA3_26560356_Chip-Seq_TH2_Human1.16011762
103FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15574465
104FOXA1_25329375_ChIP-Seq_VCAP_Human1.15574465
105SCL_19346495_ChIP-Seq_HPC-7_Human1.14913835
106SALL1_21062744_ChIP-ChIP_HESCs_Human1.14878892
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13471274
108TCF4_23295773_ChIP-Seq_U87_Human1.12573702
109NANOG_19829295_ChIP-Seq_ESCs_Human1.12189667
110SOX2_19829295_ChIP-Seq_ESCs_Human1.12189667
111NANOG_21062744_ChIP-ChIP_HESCs_Human1.12047750
112CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11198291
113* SPI1_23547873_ChIP-Seq_NB4_Human1.11183297
114KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10736606
115SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.10510569
116E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.10060688
117* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.09848287
118AR_25329375_ChIP-Seq_VCAP_Human1.08087663
119NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06933848
120PIAS1_25552417_ChIP-Seq_VCAP_Human1.06778128
121EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06569974
122EZH2_27294783_Chip-Seq_NPCs_Mouse1.06421659
123* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06343750
124RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05897428
125SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05627273
126HOXB7_26014856_ChIP-Seq_BT474_Human1.05400882
127* TFEB_21752829_ChIP-Seq_HELA_Human1.05333944
128FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05205256
129SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03035069
130NFE2_27457419_Chip-Seq_LIVER_Mouse1.01862490
131* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01818139
132GATA3_21878914_ChIP-Seq_MCF-7_Human1.00285909
133CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00051132
134MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.99685787
135IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99443949
136PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99331017
137PRDM14_20953172_ChIP-Seq_ESCs_Human0.98313692
138POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98201119
139HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98129486
140TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97489766
141UTX_26944678_Chip-Seq_JUKART_Human0.96237318
142* TCF4_22108803_ChIP-Seq_LS180_Human0.95902850
143MYB_26560356_Chip-Seq_TH2_Human0.95440843
144SMAD4_21799915_ChIP-Seq_A2780_Human0.95235979
145SRF_21415370_ChIP-Seq_HL-1_Mouse0.94184373
146POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93560543
147FLI1_21867929_ChIP-Seq_TH2_Mouse0.93486905
148ETV1_20927104_ChIP-Seq_GIST48_Human0.93175772
149MYC_18940864_ChIP-ChIP_HL60_Human0.92458839
150RUNX2_22187159_ChIP-Seq_PCA_Human0.92277900
151NCOR_22424771_ChIP-Seq_293T_Human0.92172666
152DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91797336
153CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91345098
154TCF7_22412390_ChIP-Seq_EML_Mouse0.90465447
155EZH2_22144423_ChIP-Seq_EOC_Human0.90287543
156TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89368636
157* MYB_26560356_Chip-Seq_TH1_Human0.88032351
158NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.88012028
159MAF_26560356_Chip-Seq_TH1_Human0.86469150
160POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.85568218
161MYB_21317192_ChIP-Seq_ERMYB_Mouse0.84958074
162NOTCH1_21737748_ChIP-Seq_TLL_Human0.84802565
163BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.83386500
164PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.82173086
165STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81813378
166ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81215621
167BRD4_27068464_Chip-Seq_AML-cells_Mouse0.79643521
168RUNX1_22412390_ChIP-Seq_EML_Mouse0.78574793
169SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.78435570

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.97550332
2MP0010094_abnormal_chromosome_stability4.59212450
3MP0003111_abnormal_nucleus_morphology4.36921491
4MP0008057_abnormal_DNA_replication4.16999800
5MP0003077_abnormal_cell_cycle3.89475637
6MP0004957_abnormal_blastocyst_morpholog3.61572272
7MP0008058_abnormal_DNA_repair3.02194577
8MP0002396_abnormal_hematopoietic_system2.77030074
9MP0001986_abnormal_taste_sensitivity2.75673336
10MP0008007_abnormal_cellular_replicative2.62365684
11MP0003195_calcinosis2.57608330
12MP0008877_abnormal_DNA_methylation2.31426058
13MP0000350_abnormal_cell_proliferation2.21550935
14MP0008932_abnormal_embryonic_tissue2.13529711
15MP0010307_abnormal_tumor_latency2.03384446
16MP0001730_embryonic_growth_arrest2.00484064
17MP0004808_abnormal_hematopoietic_stem1.91161127
18MP0005084_abnormal_gallbladder_morpholo1.87498784
19MP0010352_gastrointestinal_tract_polyps1.84909863
20MP0003136_yellow_coat_color1.81962491
21MP0004133_heterotaxia1.80108914
22MP0003123_paternal_imprinting1.79876093
23MP0003121_genomic_imprinting1.79693920
24MP0001672_abnormal_embryogenesis/_devel1.76717194
25MP0005380_embryogenesis_phenotype1.76717194
26MP0008995_early_reproductive_senescence1.75434512
27MP0000427_abnormal_hair_cycle1.74636332
28MP0001697_abnormal_embryo_size1.72350448
29MP0000490_abnormal_crypts_of1.68910947
30MP0006072_abnormal_retinal_apoptosis1.66592693
31MP0004142_abnormal_muscle_tone1.65536893
32MP0008872_abnormal_physiological_respon1.64993850
33MP0005551_abnormal_eye_electrophysiolog1.64603998
34MP0003984_embryonic_growth_retardation1.61777713
35MP0003786_premature_aging1.60881345
36MP0003763_abnormal_thymus_physiology1.60406697
37MP0002088_abnormal_embryonic_growth/wei1.58329849
38MP0005076_abnormal_cell_differentiation1.56917731
39MP0002085_abnormal_embryonic_tissue1.52366865
40MP0005397_hematopoietic_system_phenotyp1.52205633
41MP0001545_abnormal_hematopoietic_system1.52205633
42MP0002928_abnormal_bile_duct1.50323350
43MP0002019_abnormal_tumor_incidence1.47905121
44MP0000313_abnormal_cell_death1.45713011
45MP0002138_abnormal_hepatobiliary_system1.44683748
46MP0005645_abnormal_hypothalamus_physiol1.44283922
47MP0002277_abnormal_respiratory_mucosa1.44132290
48MP0002080_prenatal_lethality1.43577291
49MP0000703_abnormal_thymus_morphology1.43106306
50MP0003646_muscle_fatigue1.42106527
51MP0002086_abnormal_extraembryonic_tissu1.41084746
52MP0009278_abnormal_bone_marrow1.40804244
53MP0002084_abnormal_developmental_patter1.40213048
54MP0005253_abnormal_eye_physiology1.37175798
55MP0002398_abnormal_bone_marrow1.36730164
56MP0008961_abnormal_basal_metabolism1.36727611
57MP0006292_abnormal_olfactory_placode1.35190044
58MP0000631_abnormal_neuroendocrine_gland1.35046212
59MP0002638_abnormal_pupillary_reflex1.34034571
60MP0004147_increased_porphyrin_level1.32386143
61MP0002837_dystrophic_cardiac_calcinosis1.31797163
62MP0001485_abnormal_pinna_reflex1.30891930
63MP0003718_maternal_effect1.30283583
64MP0003787_abnormal_imprinting1.28997614
65MP0002210_abnormal_sex_determination1.28668958
66MP0003567_abnormal_fetal_cardiomyocyte1.24257780
67MP0000569_abnormal_digit_pigmentation1.24156337
68MP0004197_abnormal_fetal_growth/weight/1.23602002
69MP0004264_abnormal_extraembryonic_tissu1.22064070
70MP0001929_abnormal_gametogenesis1.21884965
71MP0004043_abnormal_pH_regulation1.20324783
72MP0001119_abnormal_female_reproductive1.19411937
73MP0001915_intracranial_hemorrhage1.19329293
74MP0006054_spinal_hemorrhage1.17856349
75MP0000372_irregular_coat_pigmentation1.17653154
76MP0002722_abnormal_immune_system1.17637642
77MP0003890_abnormal_embryonic-extraembry1.17425274
78MP0003283_abnormal_digestive_organ1.16362020
79MP0000689_abnormal_spleen_morphology1.15567251
80MP0009333_abnormal_splenocyte_physiolog1.15254764
81MP0003943_abnormal_hepatobiliary_system1.13777761
82MP0000383_abnormal_hair_follicle1.13660198
83MP0001919_abnormal_reproductive_system1.12270303
84MP0002009_preneoplasia1.10908435
85MP0002653_abnormal_ependyma_morphology1.10592547
86MP0004742_abnormal_vestibular_system1.08513956
87MP0002132_abnormal_respiratory_system1.08059179
88MP0002234_abnormal_pharynx_morphology1.04713902
89MP0001145_abnormal_male_reproductive1.02866992
90MP0001293_anophthalmia1.02805294
91MP0010030_abnormal_orbit_morphology1.01806928
92MP0000653_abnormal_sex_gland1.01609610
93MP0002751_abnormal_autonomic_nervous1.01380603
94MP0002429_abnormal_blood_cell1.01237597
95MP0001873_stomach_inflammation1.00221161
96MP0001764_abnormal_homeostasis0.95821713
97MP0008875_abnormal_xenobiotic_pharmacok0.95177823
98MP0000685_abnormal_immune_system0.93841251
99MP0000716_abnormal_immune_system0.92754250
100MP0001835_abnormal_antigen_presentation0.92738057
101MP0001501_abnormal_sleep_pattern0.88819141
102MP0002693_abnormal_pancreas_physiology0.88395618
103MP0005384_cellular_phenotype0.87908693
104MP0005075_abnormal_melanosome_morpholog0.87724695
105MP0005621_abnormal_cell_physiology0.87392100
106MP0002102_abnormal_ear_morphology0.86284092
107MP0000015_abnormal_ear_pigmentation0.86123986
108MP0001800_abnormal_humoral_immune0.85433215
109MP0000647_abnormal_sebaceous_gland0.84774817
110MP0000858_altered_metastatic_potential0.84420233
111MP0005174_abnormal_tail_pigmentation0.82282833
112MP0001968_abnormal_touch/_nociception0.82023023
113MP0002405_respiratory_system_inflammati0.81140842
114MP0002420_abnormal_adaptive_immunity0.80895963
115MP0004885_abnormal_endolymph0.80700245
116MP0002876_abnormal_thyroid_physiology0.80380711
117MP0001819_abnormal_immune_cell0.79691451
118MP0003699_abnormal_female_reproductive0.78979994
119MP0000465_gastrointestinal_hemorrhage0.77640455
120MP0002452_abnormal_antigen_presenting0.77497440
121MP0005391_vision/eye_phenotype0.77373160
122MP0002736_abnormal_nociception_after0.77372466
123MP0005195_abnormal_posterior_eye0.74691640
124MP0001324_abnormal_eye_pigmentation0.72211951
125MP0003878_abnormal_ear_physiology0.71491697
126MP0005377_hearing/vestibular/ear_phenot0.71491697
127MP0003566_abnormal_cell_adhesion0.70733951
128MP0009046_muscle_twitch0.70309381
129MP0009672_abnormal_birth_weight0.69073979
130MP0003937_abnormal_limbs/digits/tail_de0.69038401
131MP0003252_abnormal_bile_duct0.69034076
132MP0001529_abnormal_vocalization0.68886518
133MP0001486_abnormal_startle_reflex0.68776845
134MP0005646_abnormal_pituitary_gland0.68193511
135MP0005023_abnormal_wound_healing0.68096575
136MP0002925_abnormal_cardiovascular_devel0.68058365
137MP0001944_abnormal_pancreas_morphology0.67805550
138MP0009785_altered_susceptibility_to0.67710826
139MP0005266_abnormal_metabolism0.67450834
140MP0002006_tumorigenesis0.67335881
141MP0005389_reproductive_system_phenotype0.67076017
142MP0002095_abnormal_skin_pigmentation0.66681832
143MP0005410_abnormal_fertilization0.66504815
144MP0002075_abnormal_coat/hair_pigmentati0.66283766
145MP0002166_altered_tumor_susceptibility0.65407279
146MP0009703_decreased_birth_body0.65064159
147MP0001286_abnormal_eye_development0.64705604
148MP0000358_abnormal_cell_content/0.64694104
149MP0003119_abnormal_digestive_system0.63521059
150MP0002092_abnormal_eye_morphology0.62931899
151MP0002161_abnormal_fertility/fecundity0.62799265
152MP0005671_abnormal_response_to0.62382838
153MP0002723_abnormal_immune_serum0.60352273
154MP0003698_abnormal_male_reproductive0.60092604
155MP0002160_abnormal_reproductive_system0.60090917
156MP0002938_white_spotting0.58878848
157MP0003436_decreased_susceptibility_to0.58716947
158MP0002111_abnormal_tail_morphology0.58151394
159MP0000477_abnormal_intestine_morphology0.56867882

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.86474170
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.70336162
3Pancreatic cysts (HP:0001737)4.10427465
4Birth length less than 3rd percentile (HP:0003561)3.81857449
5Abnormality of chromosome stability (HP:0003220)3.73490577
6Abnormality of the fingertips (HP:0001211)3.71175291
7Abnormality of midbrain morphology (HP:0002418)3.54173258
8Molar tooth sign on MRI (HP:0002419)3.54173258
9Aplasia/Hypoplasia of the uvula (HP:0010293)3.50921596
10Pancreatic fibrosis (HP:0100732)3.49600083
11Meckel diverticulum (HP:0002245)3.44460073
12Medulloblastoma (HP:0002885)3.44360739
13Abnormality of the ileum (HP:0001549)3.37614585
14Ectopic kidney (HP:0000086)3.30247310
15Reticulocytopenia (HP:0001896)3.28101388
16Abnormality of the preputium (HP:0100587)3.26223421
17Myelodysplasia (HP:0002863)3.22947057
18Patellar aplasia (HP:0006443)3.22626558
19Degeneration of anterior horn cells (HP:0002398)3.20528463
20Abnormality of the anterior horn cell (HP:0006802)3.20528463
21Nephronophthisis (HP:0000090)3.14336029
22Hypoplasia of the pons (HP:0012110)3.14288687
23Congenital stationary night blindness (HP:0007642)3.12832457
24True hermaphroditism (HP:0010459)3.08876760
25Abnormality of the pons (HP:0007361)3.07252008
26Ependymoma (HP:0002888)3.06683488
27Abnormality of the renal cortex (HP:0011035)2.99566183
28Chronic hepatic failure (HP:0100626)2.94555398
29Small intestinal stenosis (HP:0012848)2.94371619
30Duodenal stenosis (HP:0100867)2.94371619
31Abnormality of DNA repair (HP:0003254)2.93403905
32Volvulus (HP:0002580)2.90267087
33Aplasia/Hypoplasia of the patella (HP:0006498)2.89872610
34Stomach cancer (HP:0012126)2.82545272
35Rhabdomyosarcoma (HP:0002859)2.78534496
36Impulsivity (HP:0100710)2.75857969
37Abnormality of the renal medulla (HP:0100957)2.75369951
38Type II lissencephaly (HP:0007260)2.75283146
39Breast hypoplasia (HP:0003187)2.73395928
40Cerebellar dysplasia (HP:0007033)2.71700704
41Medial flaring of the eyebrow (HP:0010747)2.70566672
42Agnosia (HP:0010524)2.70412674
43Optic nerve coloboma (HP:0000588)2.69739071
44Aplastic anemia (HP:0001915)2.67005955
45Bone marrow hypocellularity (HP:0005528)2.60869008
46Abnormality of the carotid arteries (HP:0005344)2.55198853
47Congenital, generalized hypertrichosis (HP:0004540)2.55168085
48Sloping forehead (HP:0000340)2.54858104
49Clubbing of toes (HP:0100760)2.53999545
50Tubular atrophy (HP:0000092)2.52270130
51Absent thumb (HP:0009777)2.47802684
52Increased nuchal translucency (HP:0010880)2.44048429
53Colon cancer (HP:0003003)2.43762690
54Cafe-au-lait spot (HP:0000957)2.42135723
55Attenuation of retinal blood vessels (HP:0007843)2.41829213
56Abnormality of the duodenum (HP:0002246)2.39114828
57Nephroblastoma (Wilms tumor) (HP:0002667)2.38513588
58Hyperventilation (HP:0002883)2.36595198
59Renal cortical cysts (HP:0000803)2.36433517
60Protruding tongue (HP:0010808)2.31101143
61Abnormal lung lobation (HP:0002101)2.29467525
62Basal cell carcinoma (HP:0002671)2.26600267
63Neoplasm of the oral cavity (HP:0100649)2.24489143
64Abnormal drinking behavior (HP:0030082)2.24118405
65Polydipsia (HP:0001959)2.24118405
66Neoplasm of striated muscle (HP:0009728)2.22697492
67Fair hair (HP:0002286)2.21267355
68Selective tooth agenesis (HP:0001592)2.18412201
69Short 4th metacarpal (HP:0010044)2.17568659
70Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.17568659
71Absent radius (HP:0003974)2.17453664
72Oral leukoplakia (HP:0002745)2.17034539
73Embryonal renal neoplasm (HP:0011794)2.16967610
74Deep philtrum (HP:0002002)2.16288657
75Cystic liver disease (HP:0006706)2.14611034
76Abnormal number of erythroid precursors (HP:0012131)2.13575519
77Acute myeloid leukemia (HP:0004808)2.12113353
78Duplicated collecting system (HP:0000081)2.09878958
79Long eyelashes (HP:0000527)2.09850714
80Aplasia/Hypoplasia of the sternum (HP:0006714)2.09103862
81Thrombocytosis (HP:0001894)2.08861202
82Lipid accumulation in hepatocytes (HP:0006561)2.08574525
83Spinal muscular atrophy (HP:0007269)2.06026428
84High pitched voice (HP:0001620)2.04263304
85Progressive inability to walk (HP:0002505)2.03856834
86Short thumb (HP:0009778)2.03694835
87Abnormality of B cell number (HP:0010975)2.03189148
88Abnormality of the labia minora (HP:0012880)2.02960472
89Nephrogenic diabetes insipidus (HP:0009806)2.02481452
90Absent forearm bone (HP:0003953)2.02086719
91Aplasia involving forearm bones (HP:0009822)2.02086719
92Combined immunodeficiency (HP:0005387)1.99994544
93Abnormality of cells of the erythroid lineage (HP:0012130)1.98923470
94Lissencephaly (HP:0001339)1.98923373
95Aplasia/Hypoplasia of the tibia (HP:0005772)1.98434074
96Abnormality of the renal collecting system (HP:0004742)1.98288233
97Inability to walk (HP:0002540)1.97785019
98Abnormal number of incisors (HP:0011064)1.95776292
99Congenital primary aphakia (HP:0007707)1.95582638
100Tracheoesophageal fistula (HP:0002575)1.94988093
10111 pairs of ribs (HP:0000878)1.94691627
102Supernumerary spleens (HP:0009799)1.93723117
103Furrowed tongue (HP:0000221)1.92800206
104Carpal bone hypoplasia (HP:0001498)1.92674118
105Prominent nose (HP:0000448)1.92587175
106Gait imbalance (HP:0002141)1.89805638
107IgM deficiency (HP:0002850)1.89154439
108Triphalangeal thumb (HP:0001199)1.88817187
109Lymphoma (HP:0002665)1.87212588
110Sclerocornea (HP:0000647)1.87042606
111Small hand (HP:0200055)1.86999838
112Concave nail (HP:0001598)1.86479876
113Aplasia/Hypoplasia of the tongue (HP:0010295)1.86038036
114Homocystinuria (HP:0002156)1.85872625
115Abnormality of homocysteine metabolism (HP:0010919)1.85872625
1163-Methylglutaconic aciduria (HP:0003535)1.84653409
117Abolished electroretinogram (ERG) (HP:0000550)1.83954395
118Poikiloderma (HP:0001029)1.83430729
119Astrocytoma (HP:0009592)1.83225574
120Abnormality of the astrocytes (HP:0100707)1.83225574
121Amaurosis fugax (HP:0100576)1.82631803
122Squamous cell carcinoma (HP:0002860)1.82207300
123Bilateral microphthalmos (HP:0007633)1.81956005
124Abnormal biliary tract physiology (HP:0012439)1.81420400
125Bile duct proliferation (HP:0001408)1.81420400
126Abnormal rod and cone electroretinograms (HP:0008323)1.80393132
127Hypoplastic iliac wings (HP:0002866)1.79299356
128Increased CSF lactate (HP:0002490)1.79272949
129Horseshoe kidney (HP:0000085)1.78952638
130Congenital hepatic fibrosis (HP:0002612)1.78773599
131Gaze-evoked nystagmus (HP:0000640)1.78193670
132Atresia of the external auditory canal (HP:0000413)1.77193552
133Deviation of the thumb (HP:0009603)1.76623438
134Pendular nystagmus (HP:0012043)1.75657921
135Proximal placement of thumb (HP:0009623)1.75549668
136Cutis marmorata (HP:0000965)1.74211482
137Oligodactyly (hands) (HP:0001180)1.74134768
138Severe muscular hypotonia (HP:0006829)1.73914351
139Genital tract atresia (HP:0001827)1.72765066
140Clumsiness (HP:0002312)1.72634536
141Neoplasm of the pancreas (HP:0002894)1.72224534
142Anencephaly (HP:0002323)1.72216792
143Hypothermia (HP:0002045)1.72084232
144Neoplasm of the colon (HP:0100273)1.71327730
145Genetic anticipation (HP:0003743)1.71317671
146Bony spicule pigmentary retinopathy (HP:0007737)1.71300016
147Stomatitis (HP:0010280)1.70990566
148Increased hepatocellular lipid droplets (HP:0006565)1.70963359
149Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.69868966
150Skull defect (HP:0001362)1.69035095
151Glioma (HP:0009733)1.68927625
152Facial hemangioma (HP:0000329)1.68785113
153Abnormal delayed hypersensitivity skin test (HP:0002963)1.68717991
154Postaxial foot polydactyly (HP:0001830)1.68522690
155Abnormality of alanine metabolism (HP:0010916)1.68388578
156Hyperalaninemia (HP:0003348)1.68388578
157Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.68388578
158Febrile seizures (HP:0002373)1.68216554
159Arteriovenous malformation (HP:0100026)1.67937427
160Abnormality of the intervertebral disk (HP:0005108)1.67826586
161Cellular immunodeficiency (HP:0005374)1.67814608
162Poor coordination (HP:0002370)1.67091482
163Methylmalonic acidemia (HP:0002912)1.66892680
164Polyuria (HP:0000103)1.65511574
165Overlapping toe (HP:0001845)1.65117359
166Acute lymphatic leukemia (HP:0006721)1.64993679
167Abnormality of chromosome segregation (HP:0002916)1.64418218
168Widely spaced teeth (HP:0000687)1.63727843
169Hypoplasia of the capital femoral epiphysis (HP:0003090)1.63312975
170Premature graying of hair (HP:0002216)1.63197163
171Ovarian neoplasm (HP:0100615)1.61301611
172Recurrent viral infections (HP:0004429)1.61285400
173Sandal gap (HP:0001852)1.60672130

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.65792968
2CDC74.50855121
3BMPR1B3.36189655
4BUB13.18168044
5CDK123.01778747
6TTK2.96303612
7EEF2K2.93733661
8NEK22.89270237
9WEE12.86326602
10NUAK12.55442476
11STK102.29818371
12SRPK12.26068406
13EIF2AK12.17036694
14ADRBK22.13537998
15PLK12.04985279
16ACVR1B1.94660680
17ATR1.94514694
18CDK71.91178744
19PLK41.87180944
20WNK31.84156384
21RPS6KB21.74268160
22MAP3K101.71950163
23CHEK21.71166629
24BRSK21.71005830
25MAP4K11.70520364
26WNK41.67761945
27CDK41.65204258
28BRD41.63130839
29AURKB1.61035060
30STK41.56459137
31PNCK1.53732098
32PASK1.51981910
33TSSK61.49167120
34VRK11.45504808
35EIF2AK31.43100300
36TRPM71.40395282
37MAP3K81.39872541
38MAP3K41.38241473
39SIK21.37447009
40CHEK11.37246178
41MKNK11.32263027
42DYRK31.31673501
43PLK31.29813133
44OXSR11.27428315
45IKBKB1.26885750
46TAOK31.25022945
47RPS6KA41.24465002
48GRK11.22510682
49TAF11.21677071
50TGFBR11.21004306
51MST41.18557358
52STK31.17266662
53BRAF1.17154450
54MAP4K21.15766372
55ATM1.15724629
56SIK31.15140133
57TNIK1.14995664
58CCNB11.12483998
59MAPK151.12357107
60NEK11.11729313
61CLK11.10987921
62MKNK21.09358260
63MARK31.08412005
64STK38L1.05815565
65MAP3K141.04164011
66FLT31.03997842
67CAMKK21.03734311
68CDK81.02446028
69PIM11.02269181
70AURKA1.01283579
71CDK20.98344823
72AKT30.97154992
73TXK0.96849553
74PAK40.93747473
75MELK0.92900770
76MAPK130.91906547
77LATS10.91227018
78MAP3K60.90289491
79IRAK10.88267016
80GRK60.87858285
81TESK20.87148944
82BRSK10.86257318
83CDK60.85215682
84STK390.82604887
85INSRR0.81235713
86NLK0.77834826
87IKBKE0.76571972
88MAPKAPK30.74692610
89CDK10.74664494
90CAMK1D0.74331350
91CHUK0.74271136
92DYRK20.72250832
93IRAK40.72113028
94TRIM280.71853759
95STK240.71367335
96ERBB30.71285705
97PAK30.69493135
98ADRBK10.68842856
99BTK0.68040455
100KIT0.67452545
101PKN20.67035042
102JAK30.65556243
103TEC0.64331170
104MTOR0.62592082
105YES10.60521569
106CDK90.59995422
107SGK20.59963253
108MOS0.59173881
109CDK30.58683226
110BCR0.57721448
111CAMK1G0.57103433
112PINK10.56645157
113ZAK0.55464087
114CASK0.54225077
115CSF1R0.54198270
116LRRK20.52067212
117FGFR20.49846192
118PRKCQ0.47976281
119ZAP700.47049662
120TLK10.46165780
121KSR10.45375274
122CSNK2A10.44156696
123MAPK140.43911904
124SYK0.43878022
125SGK30.43834172
126RPS6KB10.43458062
127CDK190.43457197
128WNK10.43455396
129PIK3CG0.42477572
130STK110.41884565
131EIF2AK20.40471074
132ITK0.40212746
133MAPK110.39348304
134AKT10.39090437
135CSNK2A20.38559826
136VRK20.37849456
137PIK3CA0.37333116
138MAP2K30.37324072
139PAK10.36182654
140CSNK1G10.36129077
141PKN10.35918065
142EPHA20.35778532
143RPS6KA60.35217327
144STK160.34486188
145MUSK0.34439174
146PRKCG0.33372094
147PRKDC0.32785830
148RPS6KL10.32757102
149RPS6KC10.32757102
150TESK10.31653072
151MAP2K60.30972534
152MAPK10.30940997
153RPS6KA50.30770604
154CSNK1D0.28482209

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.94269790
2Mismatch repair_Homo sapiens_hsa034304.29638651
3Base excision repair_Homo sapiens_hsa034103.34051906
4Cell cycle_Homo sapiens_hsa041103.20117069
5Homologous recombination_Homo sapiens_hsa034403.19023383
6Spliceosome_Homo sapiens_hsa030403.00463083
7RNA transport_Homo sapiens_hsa030132.85105448
8Fanconi anemia pathway_Homo sapiens_hsa034602.84255146
9Nucleotide excision repair_Homo sapiens_hsa034202.79555659
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.78163352
11Phototransduction_Homo sapiens_hsa047442.33123714
12One carbon pool by folate_Homo sapiens_hsa006702.31132288
13Non-homologous end-joining_Homo sapiens_hsa034502.28989202
14mRNA surveillance pathway_Homo sapiens_hsa030152.22711761
15RNA degradation_Homo sapiens_hsa030182.22548149
16Linoleic acid metabolism_Homo sapiens_hsa005912.16232541
17Maturity onset diabetes of the young_Homo sapiens_hsa049502.15961247
18Basal transcription factors_Homo sapiens_hsa030222.14126597
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.11812509
20Protein export_Homo sapiens_hsa030602.07040430
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.03461678
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.98195542
23RNA polymerase_Homo sapiens_hsa030201.97235604
24Nitrogen metabolism_Homo sapiens_hsa009101.92421392
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.86874214
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.83747382
27Ribosome_Homo sapiens_hsa030101.82658080
28Pyrimidine metabolism_Homo sapiens_hsa002401.81743412
29p53 signaling pathway_Homo sapiens_hsa041151.67608629
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.64051677
31Asthma_Homo sapiens_hsa053101.63378014
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.56463816
33Oxidative phosphorylation_Homo sapiens_hsa001901.52656998
34Herpes simplex infection_Homo sapiens_hsa051681.42505795
35Graft-versus-host disease_Homo sapiens_hsa053321.39875720
36Ether lipid metabolism_Homo sapiens_hsa005651.37755909
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34370376
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.31401174
39Type I diabetes mellitus_Homo sapiens_hsa049401.27388766
40Allograft rejection_Homo sapiens_hsa053301.25961833
41Caffeine metabolism_Homo sapiens_hsa002321.20948458
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.19128000
43Autoimmune thyroid disease_Homo sapiens_hsa053201.15705010
44Epstein-Barr virus infection_Homo sapiens_hsa051691.14140688
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13721881
46Oocyte meiosis_Homo sapiens_hsa041141.13055897
47Primary immunodeficiency_Homo sapiens_hsa053401.12872839
48Proteasome_Homo sapiens_hsa030501.12475155
49Antigen processing and presentation_Homo sapiens_hsa046121.12204078
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.11264233
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10781852
52Butanoate metabolism_Homo sapiens_hsa006501.08238005
53MicroRNAs in cancer_Homo sapiens_hsa052061.08116812
54Thyroid cancer_Homo sapiens_hsa052161.05465280
55Viral carcinogenesis_Homo sapiens_hsa052031.05412958
56Regulation of autophagy_Homo sapiens_hsa041401.05258647
57Transcriptional misregulation in cancer_Homo sapiens_hsa052021.03859396
58Tryptophan metabolism_Homo sapiens_hsa003801.01619405
59HTLV-I infection_Homo sapiens_hsa051660.99418521
60Systemic lupus erythematosus_Homo sapiens_hsa053220.99347872
61Huntingtons disease_Homo sapiens_hsa050160.97925163
62Parkinsons disease_Homo sapiens_hsa050120.97567102
63Lysine degradation_Homo sapiens_hsa003100.94257474
64Purine metabolism_Homo sapiens_hsa002300.93854215
65Dorso-ventral axis formation_Homo sapiens_hsa043200.89677406
66Chronic myeloid leukemia_Homo sapiens_hsa052200.86672736
67Notch signaling pathway_Homo sapiens_hsa043300.84240851
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83614359
69Taste transduction_Homo sapiens_hsa047420.81950538
70Colorectal cancer_Homo sapiens_hsa052100.80486933
71Hepatitis B_Homo sapiens_hsa051610.80277694
72Measles_Homo sapiens_hsa051620.78252051
73Small cell lung cancer_Homo sapiens_hsa052220.78062811
74Influenza A_Homo sapiens_hsa051640.71712989
75NF-kappa B signaling pathway_Homo sapiens_hsa040640.69687825
76Legionellosis_Homo sapiens_hsa051340.68914539
77Pancreatic cancer_Homo sapiens_hsa052120.68885743
78Acute myeloid leukemia_Homo sapiens_hsa052210.67321024
79Apoptosis_Homo sapiens_hsa042100.64353560
80Non-small cell lung cancer_Homo sapiens_hsa052230.63715682
81Circadian rhythm_Homo sapiens_hsa047100.59564709
82Olfactory transduction_Homo sapiens_hsa047400.58823687
83African trypanosomiasis_Homo sapiens_hsa051430.58281632
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.57560272
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57322098
86Adherens junction_Homo sapiens_hsa045200.57167402
87ABC transporters_Homo sapiens_hsa020100.57065393
88Viral myocarditis_Homo sapiens_hsa054160.56453402
89B cell receptor signaling pathway_Homo sapiens_hsa046620.56115388
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55663796
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54842501
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.54800107
93Selenocompound metabolism_Homo sapiens_hsa004500.54394410
94Pentose phosphate pathway_Homo sapiens_hsa000300.54089725
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53498182
96TGF-beta signaling pathway_Homo sapiens_hsa043500.53428294
97Vitamin digestion and absorption_Homo sapiens_hsa049770.53366823
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.53321109
99Shigellosis_Homo sapiens_hsa051310.50904358
100Basal cell carcinoma_Homo sapiens_hsa052170.50450962
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50406009
102Ovarian steroidogenesis_Homo sapiens_hsa049130.50348001
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50131614
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49335828
105Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49270066
106Propanoate metabolism_Homo sapiens_hsa006400.48683119
107Prostate cancer_Homo sapiens_hsa052150.48159957
108Endometrial cancer_Homo sapiens_hsa052130.47284627
109Drug metabolism - other enzymes_Homo sapiens_hsa009830.47249947
110Alzheimers disease_Homo sapiens_hsa050100.47197158
111mTOR signaling pathway_Homo sapiens_hsa041500.47138526
112Nicotine addiction_Homo sapiens_hsa050330.46674250
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46585197
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46579516
115Bladder cancer_Homo sapiens_hsa052190.45743950
116FoxO signaling pathway_Homo sapiens_hsa040680.45010623
117Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43901388
118Hippo signaling pathway_Homo sapiens_hsa043900.43759710
119Pathways in cancer_Homo sapiens_hsa052000.42751943
120N-Glycan biosynthesis_Homo sapiens_hsa005100.41714181
121Hematopoietic cell lineage_Homo sapiens_hsa046400.41480198
122Leishmaniasis_Homo sapiens_hsa051400.41071401
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40620638
124Glycerolipid metabolism_Homo sapiens_hsa005610.40464439
125TNF signaling pathway_Homo sapiens_hsa046680.38363283
126Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38294470
127NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38238041
128Arachidonic acid metabolism_Homo sapiens_hsa005900.37937837
129Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37357418
130RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37353941
131Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37247236
132Cyanoamino acid metabolism_Homo sapiens_hsa004600.37020689
133Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35565277
134Chemical carcinogenesis_Homo sapiens_hsa052040.34868211
135Jak-STAT signaling pathway_Homo sapiens_hsa046300.34745678
136Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34239758
137T cell receptor signaling pathway_Homo sapiens_hsa046600.34030783
138Retinol metabolism_Homo sapiens_hsa008300.33426751
139HIF-1 signaling pathway_Homo sapiens_hsa040660.33006288
140Cardiac muscle contraction_Homo sapiens_hsa042600.31188169
141Biosynthesis of amino acids_Homo sapiens_hsa012300.30665869
142Central carbon metabolism in cancer_Homo sapiens_hsa052300.29867154
143Cysteine and methionine metabolism_Homo sapiens_hsa002700.29666941
144Leukocyte transendothelial migration_Homo sapiens_hsa046700.28627997
145Toxoplasmosis_Homo sapiens_hsa051450.28556600
146Alcoholism_Homo sapiens_hsa050340.27426564
147Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.27407579
148Neurotrophin signaling pathway_Homo sapiens_hsa047220.25672371
149Prolactin signaling pathway_Homo sapiens_hsa049170.24972732
150Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22965078
151Sulfur relay system_Homo sapiens_hsa041220.21183167
152Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.20539513
153Wnt signaling pathway_Homo sapiens_hsa043100.18567491
154Inositol phosphate metabolism_Homo sapiens_hsa005620.18488802

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