ZC3HC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an F-box-containing protein that is a component of an SCF-type E3 ubiquitin ligase complex that regulates the onset of cell division. The G2/M transition in the cell cycle requires the interaction of the proteins cyclin B1 and cyclin-dependent kinase 1. The activated ubiquitin ligase complex targets the protein cyclin B1 for degradation, preventing this transition to mitosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)4.56498260
2establishment of protein localization to mitochondrial membrane (GO:0090151)4.46199275
3purine nucleobase biosynthetic process (GO:0009113)4.35046074
4DNA replication checkpoint (GO:0000076)4.25018789
5rRNA modification (GO:0000154)4.24615995
6nucleobase biosynthetic process (GO:0046112)4.21026020
7ribosome biogenesis (GO:0042254)4.19719817
8DNA replication initiation (GO:0006270)4.16890983
9ribosome assembly (GO:0042255)4.12800762
10termination of RNA polymerase I transcription (GO:0006363)4.08364655
11regulation of nuclear cell cycle DNA replication (GO:0033262)4.08077670
12cullin deneddylation (GO:0010388)4.07703678
13transcription elongation from RNA polymerase I promoter (GO:0006362)4.02162661
14proteasome assembly (GO:0043248)4.01333620
15metaphase plate congression (GO:0051310)4.00989689
16DNA strand elongation involved in DNA replication (GO:0006271)3.97296616
17telomere maintenance via semi-conservative replication (GO:0032201)3.94943771
18protein deneddylation (GO:0000338)3.92824022
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.90556901
20transcription elongation from RNA polymerase III promoter (GO:0006385)3.86092416
21termination of RNA polymerase III transcription (GO:0006386)3.86092416
22DNA strand elongation (GO:0022616)3.83369129
23chaperone-mediated protein transport (GO:0072321)3.81378955
24DNA deamination (GO:0045006)3.80789407
25maturation of SSU-rRNA (GO:0030490)3.79208310
267-methylguanosine mRNA capping (GO:0006370)3.78292751
27RNA capping (GO:0036260)3.76774296
287-methylguanosine RNA capping (GO:0009452)3.76774296
29CENP-A containing nucleosome assembly (GO:0034080)3.76570755
30transcription from RNA polymerase I promoter (GO:0006360)3.76460215
31formation of translation preinitiation complex (GO:0001731)3.68948609
32ribonucleoprotein complex biogenesis (GO:0022613)3.67626495
33rRNA methylation (GO:0031167)3.66841511
34telomere maintenance via recombination (GO:0000722)3.65600103
35chromatin remodeling at centromere (GO:0031055)3.63975282
36kinetochore assembly (GO:0051382)3.62169731
37protein K6-linked ubiquitination (GO:0085020)3.60764721
38mitochondrial respiratory chain complex I assembly (GO:0032981)3.59019713
39NADH dehydrogenase complex assembly (GO:0010257)3.59019713
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.59019713
41establishment of integrated proviral latency (GO:0075713)3.58948788
42regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.58326785
43transcription initiation from RNA polymerase I promoter (GO:0006361)3.56889594
44spliceosomal snRNP assembly (GO:0000387)3.56412813
45ribosomal large subunit biogenesis (GO:0042273)3.56389085
46regulation of mitochondrial translation (GO:0070129)3.55800335
47energy coupled proton transport, down electrochemical gradient (GO:0015985)3.55499088
48ATP synthesis coupled proton transport (GO:0015986)3.55499088
49transcription-coupled nucleotide-excision repair (GO:0006283)3.53526377
50protein complex biogenesis (GO:0070271)3.51864179
51telomere maintenance via telomere lengthening (GO:0010833)3.47287633
52DNA damage response, detection of DNA damage (GO:0042769)3.47047756
53mitochondrial respiratory chain complex assembly (GO:0033108)3.44896054
54rRNA processing (GO:0006364)3.43342645
55kinetochore organization (GO:0051383)3.43018830
56regulation of double-strand break repair via homologous recombination (GO:0010569)3.41158352
57mitotic recombination (GO:0006312)3.41115791
58maturation of 5.8S rRNA (GO:0000460)3.41075710
59establishment of chromosome localization (GO:0051303)3.40711776
60DNA ligation (GO:0006266)3.37587906
61mitotic sister chromatid segregation (GO:0000070)3.36395390
62anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.36281081
63IMP biosynthetic process (GO:0006188)3.34376040
64rRNA metabolic process (GO:0016072)3.34334859
65IMP metabolic process (GO:0046040)3.32940585
66regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.32639620
67positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.32257422
68exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.32244356
69DNA replication-independent nucleosome organization (GO:0034724)3.31911842
70DNA replication-independent nucleosome assembly (GO:0006336)3.31911842
71DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.30250123
72nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.29658780
73microtubule depolymerization (GO:0007019)3.29608116
74negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.28478289
75mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.28332629
76intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.26559954
77signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.26559954
78regulation of cellular amino acid metabolic process (GO:0006521)3.22564653
79oxidative phosphorylation (GO:0006119)3.21326586
80positive regulation of ligase activity (GO:0051351)3.20630281
81nucleotide-excision repair, DNA gap filling (GO:0006297)3.16255077
82respiratory chain complex IV assembly (GO:0008535)3.15428447
83histone exchange (GO:0043486)3.15346222
84viral mRNA export from host cell nucleus (GO:0046784)3.15238446
85pseudouridine synthesis (GO:0001522)3.14886265
86tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.14755201
87RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.14755201
88protein targeting to mitochondrion (GO:0006626)3.14199788
89resolution of meiotic recombination intermediates (GO:0000712)3.13861461
90regulation of ubiquitin-protein transferase activity (GO:0051438)3.11158544
91protein localization to chromosome, centromeric region (GO:0071459)3.10927589
92protein localization to kinetochore (GO:0034501)3.10159439
93regulation of mitotic spindle checkpoint (GO:1903504)3.09158496
94regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.09158496
95inner mitochondrial membrane organization (GO:0007007)3.09096968
96sister chromatid segregation (GO:0000819)3.07447540
97spindle checkpoint (GO:0031577)3.07341905
98tRNA methylation (GO:0030488)3.06519082
99nuclear pore organization (GO:0006999)3.04887565
100respiratory electron transport chain (GO:0022904)3.04180424
101DNA synthesis involved in DNA repair (GO:0000731)3.03393696
102negative regulation of DNA-dependent DNA replication (GO:2000104)3.01267604
103regulation of ligase activity (GO:0051340)2.99665208
104DNA-dependent DNA replication (GO:0006261)2.99207852
105synapsis (GO:0007129)2.99036125
106DNA-templated transcription, termination (GO:0006353)2.98908240
107DNA-templated transcription, elongation (GO:0006354)2.98405665
108establishment of protein localization to mitochondrion (GO:0072655)2.98207933
109negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.97739708
110negative regulation of sister chromatid segregation (GO:0033046)2.97739708
111negative regulation of mitotic sister chromatid separation (GO:2000816)2.97739708
112negative regulation of mitotic sister chromatid segregation (GO:0033048)2.97739708
113transcription elongation from RNA polymerase II promoter (GO:0006368)2.97690281
114DNA double-strand break processing (GO:0000729)2.97418015
115mitotic spindle checkpoint (GO:0071174)2.97330388
116electron transport chain (GO:0022900)2.97271126
117negative regulation of chromosome segregation (GO:0051985)2.96172089
118DNA catabolic process, exonucleolytic (GO:0000738)2.95949907
119negative regulation of ligase activity (GO:0051352)2.95337591
120negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.95337591
121mismatch repair (GO:0006298)2.95327249
122regulation of spindle organization (GO:0090224)2.95177643
123establishment of viral latency (GO:0019043)2.94785026
124signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.93737365
125signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.93737365
126signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.93737365
127G1/S transition of mitotic cell cycle (GO:0000082)2.92207599
128cell cycle G1/S phase transition (GO:0044843)2.92207599
129positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.91684264
130mitotic spindle assembly checkpoint (GO:0007094)2.90827297
131ribosomal small subunit assembly (GO:0000028)2.90711189
132maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.90398789
133somatic hypermutation of immunoglobulin genes (GO:0016446)2.90313072
134somatic diversification of immune receptors via somatic mutation (GO:0002566)2.90313072
135DNA replication-dependent nucleosome assembly (GO:0006335)2.89782699
136DNA replication-dependent nucleosome organization (GO:0034723)2.89782699
137spindle assembly checkpoint (GO:0071173)2.89318012
138cellular component biogenesis (GO:0044085)2.89212653
139spliceosomal complex assembly (GO:0000245)2.89053284
140signal transduction involved in DNA damage checkpoint (GO:0072422)2.88597828
141signal transduction involved in DNA integrity checkpoint (GO:0072401)2.88597828
142negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.87621578
143signal transduction involved in cell cycle checkpoint (GO:0072395)2.87358834
144mitotic nuclear envelope disassembly (GO:0007077)2.87340545

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.04256664
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.12825420
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.98682216
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.64339954
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.52414770
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.42299682
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.34201775
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.32960177
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.23602228
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.04474099
11* ETS1_20019798_ChIP-Seq_JURKAT_Human3.02277440
12* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.96151734
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.86902843
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.83115051
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.69884073
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.69423994
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.63096509
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.55709796
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.53702570
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.48965541
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.44328268
22VDR_23849224_ChIP-Seq_CD4+_Human2.42040805
23* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.41786352
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.28131753
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.27088484
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.21647521
27TP63_19390658_ChIP-ChIP_HaCaT_Human2.19050318
28FOXP3_21729870_ChIP-Seq_TREG_Human2.17174619
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.15099054
30YY1_21170310_ChIP-Seq_MESCs_Mouse2.09700284
31NANOG_18555785_ChIP-Seq_MESCs_Mouse2.07988966
32XRN2_22483619_ChIP-Seq_HELA_Human2.05437381
33* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.98446575
34* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.96994061
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.96260145
36* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.95381645
37DCP1A_22483619_ChIP-Seq_HELA_Human1.94744889
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.89688373
39TTF2_22483619_ChIP-Seq_HELA_Human1.87776239
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.86226058
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.83369016
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.82322516
43* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.77324172
44GABP_19822575_ChIP-Seq_HepG2_Human1.76709511
45CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.76505544
46* ELK1_19687146_ChIP-ChIP_HELA_Human1.73948769
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.72678215
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70781974
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.68620486
50E2F1_21310950_ChIP-Seq_MCF-7_Human1.65719719
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.63922513
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.59892364
53AR_21909140_ChIP-Seq_LNCAP_Human1.51074999
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.48741823
55* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45179472
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42979182
57* CIITA_25753668_ChIP-Seq_RAJI_Human1.41675375
58SOX2_18555785_ChIP-Seq_MESCs_Mouse1.38784931
59SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.35042345
60* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.33155880
61KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.31038958
62KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.31038958
63KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.31038958
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27695265
65ZNF274_21170338_ChIP-Seq_K562_Hela1.25471364
66NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.21515774
67POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21376430
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19944461
69KDM5A_27292631_Chip-Seq_BREAST_Human1.19939830
70CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.18706491
71KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.18252882
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18216510
73FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17886929
74NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.17350289
75MYC_18940864_ChIP-ChIP_HL60_Human1.15267571
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13104086
77VDR_22108803_ChIP-Seq_LS180_Human1.09140648
78TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09080422
79PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06491793
80ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04588477
81TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02772189
82RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01920094
83IRF1_19129219_ChIP-ChIP_H3396_Human1.01143051
84EWS_26573619_Chip-Seq_HEK293_Human1.00161297
85ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98380594
86CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97668550
87ELK1_22589737_ChIP-Seq_MCF10A_Human0.91935861
88SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91819111
89CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89992685
90E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87635954
91SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87076274
92SOX2_16153702_ChIP-ChIP_HESCs_Human0.85570477
93HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.85482306
94DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84486960
95CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.84186885
96NANOG_16153702_ChIP-ChIP_HESCs_Human0.83837061
97TCF3_18692474_ChIP-Seq_MESCs_Mouse0.82065915
98CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.81861372
99EGR1_19374776_ChIP-ChIP_THP-1_Human0.80509045
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.79952474
101FLI1_27457419_Chip-Seq_LIVER_Mouse0.79582398
102TCF3_18692474_ChIP-Seq_MEFs_Mouse0.79170828
103STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79075034
104KAP1_22055183_ChIP-Seq_ESCs_Mouse0.78927215
105NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.78904241
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.78146719
107* SOX17_20123909_ChIP-Seq_XEN_Mouse0.77238966
108ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.77170894
109TFEB_21752829_ChIP-Seq_HELA_Human0.76941581
110PCGF2_27294783_Chip-Seq_ESCs_Mouse0.76769974
111NANOG_21062744_ChIP-ChIP_HESCs_Human0.75482451
112CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.75164850
113GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.74776194
114NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.74724628
115FUS_26573619_Chip-Seq_HEK293_Human0.74108765
116DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.71034870
117* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.69475601
118TBX5_21415370_ChIP-Seq_HL-1_Mouse0.67913292

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.98998572
2MP0003111_abnormal_nucleus_morphology4.46061377
3MP0010094_abnormal_chromosome_stability4.32685709
4MP0008058_abnormal_DNA_repair4.22753583
5MP0008057_abnormal_DNA_replication3.93515917
6MP0003077_abnormal_cell_cycle3.55315028
7MP0004957_abnormal_blastocyst_morpholog3.36388831
8MP0006292_abnormal_olfactory_placode3.21891123
9MP0008007_abnormal_cellular_replicative2.75692508
10MP0008877_abnormal_DNA_methylation2.67245549
11MP0003786_premature_aging2.55473539
12MP0003806_abnormal_nucleotide_metabolis2.54542025
13MP0008932_abnormal_embryonic_tissue2.52989922
14MP0003718_maternal_effect2.48796382
15MP0006036_abnormal_mitochondrial_physio2.22707200
16MP0003941_abnormal_skin_development2.17364317
17MP0006035_abnormal_mitochondrial_morpho2.08040729
18MP0003123_paternal_imprinting2.02079394
19MP0004147_increased_porphyrin_level1.99462362
20MP0008260_abnormal_autophagy1.93085033
21MP0002396_abnormal_hematopoietic_system1.91087098
22MP0002102_abnormal_ear_morphology1.87674427
23MP0001188_hyperpigmentation1.78932891
24MP0003121_genomic_imprinting1.67409215
25MP0000350_abnormal_cell_proliferation1.65341673
26MP0003136_yellow_coat_color1.54570345
27MP0006072_abnormal_retinal_apoptosis1.50085459
28MP0002132_abnormal_respiratory_system1.49534707
29MP0001730_embryonic_growth_arrest1.46738981
30MP0000566_synostosis1.45110289
31MP0003315_abnormal_perineum_morphology1.43626335
32MP0002210_abnormal_sex_determination1.39705362
33MP0005380_embryogenesis_phenotype1.37873494
34MP0001672_abnormal_embryogenesis/_devel1.37873494
35MP0001293_anophthalmia1.34594416
36MP0002277_abnormal_respiratory_mucosa1.33527201
37MP0003878_abnormal_ear_physiology1.31743396
38MP0005377_hearing/vestibular/ear_phenot1.31743396
39MP0000015_abnormal_ear_pigmentation1.28164618
40MP0000490_abnormal_crypts_of1.25777298
41MP0010030_abnormal_orbit_morphology1.23803056
42MP0002160_abnormal_reproductive_system1.22907013
43MP0002938_white_spotting1.22817248
44MP0000358_abnormal_cell_content/1.22768714
45MP0005253_abnormal_eye_physiology1.20635070
46MP0000313_abnormal_cell_death1.20630364
47MP0005084_abnormal_gallbladder_morpholo1.20106375
48MP0003646_muscle_fatigue1.20080819
49MP0008995_early_reproductive_senescence1.19810655
50MP0009697_abnormal_copulation1.19536299
51MP0009333_abnormal_splenocyte_physiolog1.19336039
52MP0002837_dystrophic_cardiac_calcinosis1.18211441
53MP0004133_heterotaxia1.17974733
54MP0003890_abnormal_embryonic-extraembry1.16796976
55MP0002085_abnormal_embryonic_tissue1.13704730
56MP0009379_abnormal_foot_pigmentation1.13189586
57MP0003984_embryonic_growth_retardation1.12384363
58MP0001764_abnormal_homeostasis1.12256715
59MP0003938_abnormal_ear_development1.11793057
60MP0001145_abnormal_male_reproductive1.11528456
61MP0001697_abnormal_embryo_size1.09814991
62MP0010307_abnormal_tumor_latency1.08847153
63MP0002088_abnormal_embryonic_growth/wei1.07732716
64MP0000749_muscle_degeneration1.07517895
65MP0005075_abnormal_melanosome_morpholog1.06635350
66MP0003122_maternal_imprinting1.05659388
67MP0002736_abnormal_nociception_after1.04923750
68MP0002080_prenatal_lethality1.04283837
69MP0005389_reproductive_system_phenotype1.03373835
70MP0003787_abnormal_imprinting1.03144481
71MP0001286_abnormal_eye_development1.02313274
72MP0001929_abnormal_gametogenesis1.01945343
73MP0001986_abnormal_taste_sensitivity1.01305325
74MP0004808_abnormal_hematopoietic_stem0.98912238
75MP0008789_abnormal_olfactory_epithelium0.98906939
76MP0001119_abnormal_female_reproductive0.97597887
77MP0000653_abnormal_sex_gland0.96750920
78MP0003011_delayed_dark_adaptation0.96299225
79MP0003937_abnormal_limbs/digits/tail_de0.95977659
80MP0002095_abnormal_skin_pigmentation0.94193303
81MP0003567_abnormal_fetal_cardiomyocyte0.94163495
82MP0002233_abnormal_nose_morphology0.93663476
83MP0002019_abnormal_tumor_incidence0.93101751
84MP0002084_abnormal_developmental_patter0.92783583
85MP0005391_vision/eye_phenotype0.92065609
86MP0006276_abnormal_autonomic_nervous0.87384316
87MP0002234_abnormal_pharynx_morphology0.86654804
88MP0002638_abnormal_pupillary_reflex0.82526445
89MP0001324_abnormal_eye_pigmentation0.81436912
90MP0004197_abnormal_fetal_growth/weight/0.81224307
91MP0001485_abnormal_pinna_reflex0.80821010
92MP0002086_abnormal_extraembryonic_tissu0.79192403
93MP0000049_abnormal_middle_ear0.78809219
94MP0002751_abnormal_autonomic_nervous0.78650707
95MP0005174_abnormal_tail_pigmentation0.78224192
96MP0001919_abnormal_reproductive_system0.77923000
97MP0000631_abnormal_neuroendocrine_gland0.77143564
98MP0000372_irregular_coat_pigmentation0.77078038
99MP0004215_abnormal_myocardial_fiber0.76906355
100MP0002161_abnormal_fertility/fecundity0.76549207
101MP0000703_abnormal_thymus_morphology0.76340151
102MP0003385_abnormal_body_wall0.75895715
103MP0002111_abnormal_tail_morphology0.73518366
104MP0005408_hypopigmentation0.73157274
105MP0003755_abnormal_palate_morphology0.72851987
106MP0003119_abnormal_digestive_system0.72575431
107MP0002697_abnormal_eye_size0.72439147
108MP0005395_other_phenotype0.71755878
109MP0001186_pigmentation_phenotype0.71084423
110MP0002653_abnormal_ependyma_morphology0.69194346
111MP0005410_abnormal_fertilization0.68532577
112MP0002163_abnormal_gland_morphology0.68413421
113MP0001529_abnormal_vocalization0.67686844
114MP0002075_abnormal_coat/hair_pigmentati0.67544411
115MP0003763_abnormal_thymus_physiology0.67540623
116MP0005645_abnormal_hypothalamus_physiol0.67416273
117MP0005499_abnormal_olfactory_system0.66454425
118MP0005394_taste/olfaction_phenotype0.66454425
119MP0004145_abnormal_muscle_electrophysio0.66028637
120MP0003698_abnormal_male_reproductive0.65750230
121MP0004233_abnormal_muscle_weight0.65259022
122MP0002398_abnormal_bone_marrow0.65156129
123MP0005384_cellular_phenotype0.64097196
124MP0005171_absent_coat_pigmentation0.63221720
125MP0002722_abnormal_immune_system0.62262928
126MP0000689_abnormal_spleen_morphology0.61519882
127MP0003186_abnormal_redox_activity0.60542886
128MP0005671_abnormal_response_to0.60004988
129MP0000432_abnormal_head_morphology0.57830842
130MP0005397_hematopoietic_system_phenotyp0.57752668
131MP0001545_abnormal_hematopoietic_system0.57752668
132MP0009672_abnormal_birth_weight0.57346297
133MP0005409_darkened_coat_color0.57060427

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.38990877
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.34048530
3Chromsome breakage (HP:0040012)4.96503470
4Acute necrotizing encephalopathy (HP:0006965)4.96420622
5Abnormal mitochondria in muscle tissue (HP:0008316)4.54627487
6Acute encephalopathy (HP:0006846)4.49592668
7Breast hypoplasia (HP:0003187)4.18964738
8Mitochondrial inheritance (HP:0001427)4.07668247
9Progressive macrocephaly (HP:0004481)3.98908413
10Increased CSF lactate (HP:0002490)3.89327373
11Meckel diverticulum (HP:0002245)3.61217207
12Hepatocellular necrosis (HP:0001404)3.52886503
13Abnormality of the preputium (HP:0100587)3.51606591
14Cerebral edema (HP:0002181)3.44908949
15Patellar aplasia (HP:0006443)3.42986831
16Abnormality of the ileum (HP:0001549)3.42418956
17Aplasia/Hypoplasia of the uvula (HP:0010293)3.35727538
18Hepatic necrosis (HP:0002605)3.31281438
19Increased hepatocellular lipid droplets (HP:0006565)3.30311261
20Aplasia/Hypoplasia of the patella (HP:0006498)3.27696950
21Rough bone trabeculation (HP:0100670)3.21321344
22Duplicated collecting system (HP:0000081)3.18690834
23Abnormality of chromosome stability (HP:0003220)3.16923408
24Reticulocytopenia (HP:0001896)3.13225920
25Increased serum pyruvate (HP:0003542)3.07161399
26Abnormality of the labia minora (HP:0012880)3.05054300
27Lipid accumulation in hepatocytes (HP:0006561)3.00207154
28Absent radius (HP:0003974)3.00013978
29Cerebral hypomyelination (HP:0006808)2.97048822
30Aplasia/Hypoplasia of the sacrum (HP:0008517)2.95226987
31Abnormality of the renal collecting system (HP:0004742)2.91668816
32Impulsivity (HP:0100710)2.84933388
33Carpal bone hypoplasia (HP:0001498)2.84204157
34Abnormality of glycolysis (HP:0004366)2.81556854
35Aplasia involving forearm bones (HP:0009822)2.80753439
36Absent forearm bone (HP:0003953)2.80753439
37Ectopic kidney (HP:0000086)2.77861445
38Degeneration of anterior horn cells (HP:0002398)2.74875086
39Abnormality of the anterior horn cell (HP:0006802)2.74875086
40Duodenal stenosis (HP:0100867)2.73602101
41Small intestinal stenosis (HP:0012848)2.73602101
42Absent thumb (HP:0009777)2.71048517
43Bone marrow hypocellularity (HP:0005528)2.70876701
44Renal Fanconi syndrome (HP:0001994)2.70247038
45Increased serum lactate (HP:0002151)2.69644569
46Lactic acidosis (HP:0003128)2.62357338
47Exercise intolerance (HP:0003546)2.59468813
48Abnormal trabecular bone morphology (HP:0100671)2.56575906
49Abnormal number of erythroid precursors (HP:0012131)2.54908148
50Oral leukoplakia (HP:0002745)2.51064420
51Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.50027039
52Decreased activity of mitochondrial respiratory chain (HP:0008972)2.50027039
53Premature graying of hair (HP:0002216)2.47935354
54Triphalangeal thumb (HP:0001199)2.47003391
55Respiratory failure (HP:0002878)2.46999772
56Supernumerary spleens (HP:0009799)2.45744894
57Increased intramyocellular lipid droplets (HP:0012240)2.42190934
58Abnormality of DNA repair (HP:0003254)2.40684580
59Abnormal number of incisors (HP:0011064)2.39609072
60Microvesicular hepatic steatosis (HP:0001414)2.39113128
61Horseshoe kidney (HP:0000085)2.38742144
62Clubbing of toes (HP:0100760)2.35903082
63Optic disc pallor (HP:0000543)2.32272763
64Ureteral duplication (HP:0000073)2.30387516
65Medulloblastoma (HP:0002885)2.28671108
66Myelodysplasia (HP:0002863)2.24170943
67Septo-optic dysplasia (HP:0100842)2.24061049
68Abnormal protein glycosylation (HP:0012346)2.23621188
69Abnormal glycosylation (HP:0012345)2.23621188
70Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.23621188
71Abnormal protein N-linked glycosylation (HP:0012347)2.23621188
72Hyperglycinemia (HP:0002154)2.22524497
73Prostate neoplasm (HP:0100787)2.21630386
74Abnormality of the duodenum (HP:0002246)2.20751299
75Short thumb (HP:0009778)2.20747308
76Tracheoesophageal fistula (HP:0002575)2.19825575
77Sloping forehead (HP:0000340)2.17689212
78Leukodystrophy (HP:0002415)2.17186513
79Abnormality of the carotid arteries (HP:0005344)2.15956564
80Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.15461804
81Facial cleft (HP:0002006)2.15068843
82Hypoplasia of the pons (HP:0012110)2.10958074
83Abnormality of the pons (HP:0007361)2.10758768
84Abnormal lung lobation (HP:0002101)2.10429018
85Cleft eyelid (HP:0000625)2.10311504
86Pancreatic fibrosis (HP:0100732)2.09694261
87Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.03413612
88Agnosia (HP:0010524)2.02487475
89Type 2 muscle fiber atrophy (HP:0003554)2.01702065
90Abnormality of midbrain morphology (HP:0002418)2.00963009
91Molar tooth sign on MRI (HP:0002419)2.00963009
92Type I transferrin isoform profile (HP:0003642)1.99762405
93Lethargy (HP:0001254)1.98855747
94Stomach cancer (HP:0012126)1.98626868
95Abnormality of methionine metabolism (HP:0010901)1.96805413
96Cortical dysplasia (HP:0002539)1.95400381
97Nephroblastoma (Wilms tumor) (HP:0002667)1.95299017
98Pendular nystagmus (HP:0012043)1.95018034
99Hypoplastic pelvis (HP:0008839)1.94601262
100Selective tooth agenesis (HP:0001592)1.93851527
101Respiratory difficulties (HP:0002880)1.93574602
102Abnormality of alanine metabolism (HP:0010916)1.92492795
103Hyperalaninemia (HP:0003348)1.92492795
104Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.92492795
105Increased muscle lipid content (HP:0009058)1.92452124
106Methylmalonic aciduria (HP:0012120)1.90491273
107Breast aplasia (HP:0100783)1.89903357
108Cellular immunodeficiency (HP:0005374)1.88538266
109Methylmalonic acidemia (HP:0002912)1.88532595
110Pancreatic cysts (HP:0001737)1.87787112
111Hypoplasia of the capital femoral epiphysis (HP:0003090)1.87780939
112Neoplasm of the pancreas (HP:0002894)1.86896542
113Abnormal spermatogenesis (HP:0008669)1.86101391
114Embryonal renal neoplasm (HP:0011794)1.85517631
115Adrenal hypoplasia (HP:0000835)1.84660320
116Aplasia/Hypoplasia involving the musculature (HP:0001460)1.84607658
1173-Methylglutaconic aciduria (HP:0003535)1.84502581
118Stenosis of the external auditory canal (HP:0000402)1.84248132
119CNS demyelination (HP:0007305)1.82715709
120Aplastic anemia (HP:0001915)1.82328596
121Abnormality of serum amino acid levels (HP:0003112)1.82298772
122Reduced antithrombin III activity (HP:0001976)1.79608895
123Postnatal microcephaly (HP:0005484)1.78781408
124Aplasia/Hypoplasia of the breasts (HP:0010311)1.78742345
125Multiple enchondromatosis (HP:0005701)1.78620374
126Muscle fiber atrophy (HP:0100295)1.77812252
127Aplasia/Hypoplasia of the earlobes (HP:0009906)1.76241162
128Premature ovarian failure (HP:0008209)1.74519536
129Hypoplasia of the radius (HP:0002984)1.74053275
130Exertional dyspnea (HP:0002875)1.73248755
131Macrocytic anemia (HP:0001972)1.73073366
132Sparse eyelashes (HP:0000653)1.71501088
133Duplication of thumb phalanx (HP:0009942)1.71240022
134Colon cancer (HP:0003003)1.71207009
135CNS hypomyelination (HP:0003429)1.70753770
136Abnormality of the septum pellucidum (HP:0007375)1.70496809
137Preaxial hand polydactyly (HP:0001177)1.69619195
138Intestinal atresia (HP:0011100)1.69411720
139Pancytopenia (HP:0001876)1.68823634
140X-linked dominant inheritance (HP:0001423)1.67641936
141Ependymoma (HP:0002888)1.67368222
142True hermaphroditism (HP:0010459)1.67039237
143Prominent metopic ridge (HP:0005487)1.66385916
144Bifid tongue (HP:0010297)1.66156002
145Progressive microcephaly (HP:0000253)1.65288546
146Abnormality of the umbilical cord (HP:0010881)1.64395945
14711 pairs of ribs (HP:0000878)1.64151874
148Pallor (HP:0000980)1.64105589
149Abnormality of cells of the erythroid lineage (HP:0012130)1.63714469
150Glioma (HP:0009733)1.63587759
151Abnormality of aspartate family amino acid metabolism (HP:0010899)1.63536053
152Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.62870161
153Microretrognathia (HP:0000308)1.61982901
154Emotional lability (HP:0000712)1.60507439
155Abnormality of the metopic suture (HP:0005556)1.60437365
156Generalized aminoaciduria (HP:0002909)1.59917814
157Optic nerve coloboma (HP:0000588)1.59448830
158Lymphoma (HP:0002665)1.59446544
159Tetralogy of Fallot (HP:0001636)1.58273889
160Rectal fistula (HP:0100590)1.57966651
161Rectovaginal fistula (HP:0000143)1.57966651
162Absent septum pellucidum (HP:0001331)1.57458590

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.44209957
2WEE13.85395455
3STK163.66469773
4ZAK3.42196726
5VRK23.26598175
6SRPK13.09541599
7PLK42.85620258
8TSSK62.78647556
9EIF2AK12.59787176
10CDC72.44306069
11MKNK22.41317270
12MKNK12.25228894
13TTK2.21122777
14VRK12.10763475
15ACVR1B2.10116730
16EPHA22.03179611
17PLK32.02917069
18BCKDK2.01649584
19IRAK31.96827673
20CDK191.90386464
21PLK11.89732183
22MST41.89064887
23EIF2AK31.86997569
24AKT31.67744302
25BRSK21.67671524
26EIF2AK21.67021058
27NEK21.67011961
28TLK11.66067348
29NME21.58835588
30ATR1.57571429
31CHEK21.54359380
32CDK71.51440807
33DYRK31.43184031
34WNK31.41027923
35STK38L1.39966584
36AURKB1.24899746
37BRD41.21380695
38IRAK41.16970735
39PNCK1.16398370
40CCNB11.15183258
41MAP2K71.13736718
42TRIM281.12925673
43PLK21.12240458
44CSNK1G11.11511722
45BRSK11.10156686
46CDK81.09963401
47AURKA1.07950696
48TXK1.07485911
49CDK121.05131511
50TIE11.01976831
51DYRK20.99816184
52ADRBK20.95300017
53BCR0.94469042
54* CHEK10.93962689
55PASK0.92525707
56TAOK20.92378352
57YES10.91403573
58TAF10.83883127
59STK40.83560263
60NEK60.83207108
61RPS6KB20.82372194
62CSNK1G20.82335150
63PBK0.82328911
64BRAF0.81215391
65BMPR1B0.81169118
66CASK0.81056347
67ERBB40.79373508
68ATM0.78600744
69SIK30.74859083
70PIM10.74163882
71OXSR10.72339824
72KDR0.70904880
73PIM20.69486675
74CSNK2A10.68408715
75PINK10.68156977
76PRKCI0.66947334
77TESK20.64388502
78TGFBR10.63660844
79NUAK10.61967673
80* CDK20.61752727
81NEK10.59967659
82CSNK2A20.58659054
83WNK40.58329940
84CDK40.57924966
85CDK30.57782251
86RPS6KA50.55274255
87TEC0.54868189
88PRPF4B0.54262618
89MAP4K20.53124103
90* CDK10.52500405
91PHKG20.51115398
92PHKG10.51115398
93IKBKB0.49946560
94RPS6KA40.47376138
95LIMK10.46882858
96GRK10.45751633
97PDK20.44994149
98IRAK20.44281234
99MAP3K80.44026082
100STK100.43396361
101ERBB30.42261805
102CLK10.41188167
103NME10.41115581
104FLT30.39501020
105STK240.39436600
106PAK10.39115762
107STK30.37867639
108IRAK10.35489059
109MELK0.34736233
110MAP3K40.32891888
111NLK0.31901917
112PKN10.30475960
113CSNK1A10.29683559
114OBSCN0.29036188
115CSNK1E0.28986117
116CSNK1G30.25782182
117MARK30.25369251
118AKT20.24681619
119FRK0.24365830
120CDK140.24046220
121INSRR0.23599033
122PRKDC0.23117634
123GRK70.22824159
124PAK40.22766831
125MAP3K140.22546891
126CSNK1A1L0.22137509
127TNIK0.22045697
128MAPK140.19126903
129MAPK130.18827376
130LYN0.18465059

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030204.10957015
2DNA replication_Homo sapiens_hsa030304.10031111
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.95198877
4Mismatch repair_Homo sapiens_hsa034303.75929669
5Proteasome_Homo sapiens_hsa030503.56747287
6Homologous recombination_Homo sapiens_hsa034403.14894088
7Spliceosome_Homo sapiens_hsa030403.01118744
8Base excision repair_Homo sapiens_hsa034102.93296630
9RNA transport_Homo sapiens_hsa030132.90379180
10Fanconi anemia pathway_Homo sapiens_hsa034602.83978070
11Nucleotide excision repair_Homo sapiens_hsa034202.80827804
12Ribosome_Homo sapiens_hsa030102.75843529
13Pyrimidine metabolism_Homo sapiens_hsa002402.62104703
14Basal transcription factors_Homo sapiens_hsa030222.57414351
15Cell cycle_Homo sapiens_hsa041102.47604624
16Vitamin B6 metabolism_Homo sapiens_hsa007502.25454327
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.24389898
18Non-homologous end-joining_Homo sapiens_hsa034502.12308964
19One carbon pool by folate_Homo sapiens_hsa006701.97816078
20RNA degradation_Homo sapiens_hsa030181.88553780
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.80931941
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.79086029
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72937557
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.72786350
25Purine metabolism_Homo sapiens_hsa002301.64770345
26mRNA surveillance pathway_Homo sapiens_hsa030151.63755067
27Propanoate metabolism_Homo sapiens_hsa006401.58474705
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57696730
29Pyruvate metabolism_Homo sapiens_hsa006201.57029316
30Alzheimers disease_Homo sapiens_hsa050101.55727914
31p53 signaling pathway_Homo sapiens_hsa041151.53695649
32Fatty acid elongation_Homo sapiens_hsa000621.36309983
33Epstein-Barr virus infection_Homo sapiens_hsa051691.30660461
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.28373411
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25245319
36Carbon metabolism_Homo sapiens_hsa012001.22828767
37Steroid biosynthesis_Homo sapiens_hsa001001.21486734
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.06989927
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.00054716
40Cardiac muscle contraction_Homo sapiens_hsa042600.98640305
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95242928
42Herpes simplex infection_Homo sapiens_hsa051680.95141722
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95043231
44Regulation of autophagy_Homo sapiens_hsa041400.92517879
45Butanoate metabolism_Homo sapiens_hsa006500.91489040
46Folate biosynthesis_Homo sapiens_hsa007900.90426813
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87583747
48Systemic lupus erythematosus_Homo sapiens_hsa053220.80362066
49Primary bile acid biosynthesis_Homo sapiens_hsa001200.79002515
50Peroxisome_Homo sapiens_hsa041460.78792419
51NF-kappa B signaling pathway_Homo sapiens_hsa040640.71981632
52Oocyte meiosis_Homo sapiens_hsa041140.69532753
53Intestinal immune network for IgA production_Homo sapiens_hsa046720.69526564
54Huntingtons disease_Homo sapiens_hsa050160.68952180
55Primary immunodeficiency_Homo sapiens_hsa053400.66085533
56Fatty acid metabolism_Homo sapiens_hsa012120.65835508
57Vitamin digestion and absorption_Homo sapiens_hsa049770.65000848
58Viral carcinogenesis_Homo sapiens_hsa052030.61881828
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58741365
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58581015
61Arachidonic acid metabolism_Homo sapiens_hsa005900.58506778
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57501750
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.57492699
64Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55849531
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54822294
66Allograft rejection_Homo sapiens_hsa053300.53990397
67Protein export_Homo sapiens_hsa030600.53101347
68Measles_Homo sapiens_hsa051620.53041705
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.52944795
70HTLV-I infection_Homo sapiens_hsa051660.52624651
71Pentose phosphate pathway_Homo sapiens_hsa000300.50870302
72Autoimmune thyroid disease_Homo sapiens_hsa053200.48764036
73Antigen processing and presentation_Homo sapiens_hsa046120.47552847
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44972036
75Fatty acid degradation_Homo sapiens_hsa000710.44677992
76Sulfur relay system_Homo sapiens_hsa041220.44557792
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43955485
78Basal cell carcinoma_Homo sapiens_hsa052170.40967096
79beta-Alanine metabolism_Homo sapiens_hsa004100.40616380
80Graft-versus-host disease_Homo sapiens_hsa053320.39979729
81Glutathione metabolism_Homo sapiens_hsa004800.39817637
82Sphingolipid metabolism_Homo sapiens_hsa006000.39758688
83Arginine and proline metabolism_Homo sapiens_hsa003300.39349313
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38782945
85Collecting duct acid secretion_Homo sapiens_hsa049660.37076866
86Hematopoietic cell lineage_Homo sapiens_hsa046400.36989432
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36610637
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36001516
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35764948
90Sulfur metabolism_Homo sapiens_hsa009200.35472330
91Hedgehog signaling pathway_Homo sapiens_hsa043400.35241990
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35050807
93Legionellosis_Homo sapiens_hsa051340.34871634
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34692220
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34412096
96Fructose and mannose metabolism_Homo sapiens_hsa000510.34073650
97Parkinsons disease_Homo sapiens_hsa050120.33892060
98Oxidative phosphorylation_Homo sapiens_hsa001900.32051757
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31620247
100Metabolic pathways_Homo sapiens_hsa011000.31511775
101Asthma_Homo sapiens_hsa053100.30691423
102Apoptosis_Homo sapiens_hsa042100.30354998
103Tryptophan metabolism_Homo sapiens_hsa003800.30096804
104Galactose metabolism_Homo sapiens_hsa000520.30053827
105MicroRNAs in cancer_Homo sapiens_hsa052060.29150673
106Influenza A_Homo sapiens_hsa051640.27893635
107Hippo signaling pathway_Homo sapiens_hsa043900.27479673
108Phototransduction_Homo sapiens_hsa047440.27101296
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27060137
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27058819
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.26737232
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.26397351
113Selenocompound metabolism_Homo sapiens_hsa004500.26087873
114Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.24504161
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24162396
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.23045000
117Olfactory transduction_Homo sapiens_hsa047400.22571965
118Biosynthesis of amino acids_Homo sapiens_hsa012300.22164369
119Alcoholism_Homo sapiens_hsa050340.21752471
120Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.21442849
121TGF-beta signaling pathway_Homo sapiens_hsa043500.20513671
122Notch signaling pathway_Homo sapiens_hsa043300.20085855
123Tyrosine metabolism_Homo sapiens_hsa003500.18881418
124Small cell lung cancer_Homo sapiens_hsa052220.18260406
125Linoleic acid metabolism_Homo sapiens_hsa005910.18011432
126Nitrogen metabolism_Homo sapiens_hsa009100.17418517
127Hepatitis B_Homo sapiens_hsa051610.15333995
128Rheumatoid arthritis_Homo sapiens_hsa053230.15184166
129Retinol metabolism_Homo sapiens_hsa008300.13770668
130Pathways in cancer_Homo sapiens_hsa052000.13539327
131Circadian rhythm_Homo sapiens_hsa047100.13206279
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.11608425
133Wnt signaling pathway_Homo sapiens_hsa043100.11465303
134N-Glycan biosynthesis_Homo sapiens_hsa005100.11226793
135Prostate cancer_Homo sapiens_hsa052150.11180814
136Fat digestion and absorption_Homo sapiens_hsa049750.10785715
137Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.10555268
138Renin-angiotensin system_Homo sapiens_hsa046140.09446201
139Vibrio cholerae infection_Homo sapiens_hsa051100.09332159
140Caffeine metabolism_Homo sapiens_hsa002320.09153220
141Lysine degradation_Homo sapiens_hsa003100.08367770
142Chemical carcinogenesis_Homo sapiens_hsa052040.06449767

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