ZC3H12D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.99961559
2antigen processing and presentation of endogenous antigen (GO:0019883)6.50963721
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.23465001
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.23465001
5negative T cell selection (GO:0043383)6.03656164
6negative thymic T cell selection (GO:0045060)5.99892936
7positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.55002627
8positive thymic T cell selection (GO:0045059)5.48777101
9response to interleukin-15 (GO:0070672)5.38407701
10regulation of B cell receptor signaling pathway (GO:0050855)5.37002698
11regulation of gamma-delta T cell differentiation (GO:0045586)5.27241043
12regulation of gamma-delta T cell activation (GO:0046643)5.08597366
13regulation of interleukin-12 biosynthetic process (GO:0045075)5.00687229
14thymic T cell selection (GO:0045061)4.93186464
15positive T cell selection (GO:0043368)4.90224226
16cellular response to interleukin-15 (GO:0071350)4.86609438
17T cell selection (GO:0045058)4.74242398
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.64333563
19regulation of interleukin-2 biosynthetic process (GO:0045076)4.56801474
20regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.51130386
21B cell receptor signaling pathway (GO:0050853)4.47232292
22regulation of alpha-beta T cell proliferation (GO:0046640)4.37109411
23regulation of isotype switching to IgG isotypes (GO:0048302)4.33426785
24tolerance induction (GO:0002507)4.31078151
25positive regulation of interleukin-2 production (GO:0032743)4.22273589
26T cell migration (GO:0072678)4.17937830
27regulation of T cell tolerance induction (GO:0002664)4.17050299
28interferon-gamma production (GO:0032609)4.12591114
29negative regulation of cell killing (GO:0031342)4.06180646
30negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.06180646
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.01211634
32leukocyte aggregation (GO:0070486)3.99274528
33regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.96644308
34regulation of B cell differentiation (GO:0045577)3.93293098
35T cell costimulation (GO:0031295)3.93242275
36DNA deamination (GO:0045006)3.88149220
37lymphocyte costimulation (GO:0031294)3.87126908
38NIK/NF-kappaB signaling (GO:0038061)3.80316884
39positive regulation of humoral immune response (GO:0002922)3.78690932
40antigen receptor-mediated signaling pathway (GO:0050851)3.75652606
41regulation of regulatory T cell differentiation (GO:0045589)3.74360702
42positive regulation of B cell differentiation (GO:0045579)3.69263366
43positive regulation of defense response to virus by host (GO:0002230)3.63505641
44positive regulation of isotype switching (GO:0045830)3.61369138
45T cell receptor signaling pathway (GO:0050852)3.56531421
46activated T cell proliferation (GO:0050798)3.52854731
47mature B cell differentiation (GO:0002335)3.52782699
48regulation of T cell receptor signaling pathway (GO:0050856)3.51637311
49positive regulation of natural killer cell differentiation (GO:0032825)3.50150821
50JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.45708511
51interferon-gamma-mediated signaling pathway (GO:0060333)3.45342775
52regulation of B cell proliferation (GO:0030888)3.45109535
53response to type I interferon (GO:0034340)3.43318775
54germinal center formation (GO:0002467)3.41812448
55negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.40567836
56cellular response to type I interferon (GO:0071357)3.37565301
57type I interferon signaling pathway (GO:0060337)3.37565301
58positive regulation of alpha-beta T cell proliferation (GO:0046641)3.37182474
59behavioral response to nicotine (GO:0035095)3.36384052
60negative regulation of T cell mediated immunity (GO:0002710)3.32462577
61regulation of interleukin-2 production (GO:0032663)3.29775758
62positive regulation of B cell proliferation (GO:0030890)3.27096475
63defense response to protozoan (GO:0042832)3.26467772
64lymphocyte homeostasis (GO:0002260)3.24950960
65positive regulation of cytokine biosynthetic process (GO:0042108)3.24504636
66positive regulation of immunoglobulin production (GO:0002639)3.22540255
67positive regulation of natural killer cell mediated immunity (GO:0002717)3.22234116
68positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.22234116
69B cell proliferation (GO:0042100)3.22200865
70myeloid dendritic cell activation (GO:0001773)3.21358236
71positive regulation of immunoglobulin mediated immune response (GO:0002891)3.21343912
72positive regulation of B cell mediated immunity (GO:0002714)3.21343912
73positive regulation of B cell activation (GO:0050871)3.21044320
74T cell homeostasis (GO:0043029)3.19111389
75positive regulation of DNA recombination (GO:0045911)3.18855355
76B cell homeostasis (GO:0001782)3.18545572
77mast cell activation (GO:0045576)3.15981919
78response to protozoan (GO:0001562)3.15092248
79CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.14673178
80fucose catabolic process (GO:0019317)3.14562539
81L-fucose metabolic process (GO:0042354)3.14562539
82L-fucose catabolic process (GO:0042355)3.14562539
83positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.13641856
84positive regulation of granulocyte differentiation (GO:0030854)3.10855658
85regulation of natural killer cell mediated immunity (GO:0002715)3.10183285
86regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.10183285
87negative regulation of B cell proliferation (GO:0030889)3.10177388
88regulation of type I interferon-mediated signaling pathway (GO:0060338)3.09347959
89myeloid dendritic cell differentiation (GO:0043011)3.08390419
90regulation of interferon-beta biosynthetic process (GO:0045357)3.08180726
91modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.08067900
92modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.08067900
93positive regulation by organism of defense response of other organism involved in symbiotic interact3.08067900
94modulation by symbiont of host immune response (GO:0052553)3.08067900
95positive regulation by symbiont of host defense response (GO:0052509)3.08067900
96modulation by symbiont of host defense response (GO:0052031)3.08067900
97regulation of isotype switching (GO:0045191)3.06569260
98negative regulation of interleukin-12 production (GO:0032695)3.05228990
99positive regulation of antigen processing and presentation (GO:0002579)3.04955116
100tyrosine phosphorylation of STAT protein (GO:0007260)3.03554141
101positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.02215613
102pyrimidine ribonucleoside catabolic process (GO:0046133)3.00297180
103cytidine deamination (GO:0009972)2.99959815
104cytidine metabolic process (GO:0046087)2.99959815
105cytidine catabolic process (GO:0006216)2.99959815
106regulation of response to interferon-gamma (GO:0060330)2.99568279
107immune response-activating cell surface receptor signaling pathway (GO:0002429)2.98850533
108regulation of B cell activation (GO:0050864)2.98066778
109mast cell activation involved in immune response (GO:0002279)2.98021581
110mast cell degranulation (GO:0043303)2.98021581
111regulation of B cell mediated immunity (GO:0002712)2.97711441
112regulation of immunoglobulin production (GO:0002637)2.95805579
113regulation of tolerance induction (GO:0002643)2.94547626
114T cell proliferation (GO:0042098)2.94304050
115regulation of T cell mediated cytotoxicity (GO:0001914)2.94273549
116regulation of alpha-beta T cell activation (GO:0046634)2.94251923
117positive regulation of T cell mediated cytotoxicity (GO:0001916)2.92583627
118alpha-beta T cell differentiation (GO:0046632)2.90733261
119negative regulation of lymphocyte mediated immunity (GO:0002707)2.83102438
120regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.81834937
121epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.81706843
122regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.78583274
123regulation of MHC class I biosynthetic process (GO:0045343)2.73934759
124mucosal-associated lymphoid tissue development (GO:0048537)2.73875318
125Peyers patch development (GO:0048541)2.73875318
126regulation of defense response to virus by host (GO:0050691)2.73364851
127regulation of cell killing (GO:0031341)2.71321869
128positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.69890253
129regulation of leukocyte mediated cytotoxicity (GO:0001910)2.69693381
130positive regulation of T cell differentiation in thymus (GO:0033089)2.68763392
131positive regulation of cell killing (GO:0031343)2.68563718
132negative regulation of telomere maintenance (GO:0032205)2.67769999
133cellular response to interferon-beta (GO:0035458)2.67503276
134alpha-beta T cell activation (GO:0046631)2.67181245
135negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.59859828
136negative regulation of alpha-beta T cell activation (GO:0046636)2.59661128
137negative regulation of mast cell activation (GO:0033004)2.59659458
138regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.59409203
139response to pheromone (GO:0019236)2.56538022
140indolalkylamine metabolic process (GO:0006586)2.56253550
141regulation of antigen processing and presentation (GO:0002577)2.55831791
142positive regulation of calcium-mediated signaling (GO:0050850)2.52170957
143immunoglobulin mediated immune response (GO:0016064)2.52011977
144regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.48373377
145negative regulation of adaptive immune response (GO:0002820)2.47527207
146cellular response to exogenous dsRNA (GO:0071360)2.46987944

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.55106098
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.88970016
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.41758910
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.68444434
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.05628771
6E2F7_22180533_ChIP-Seq_HELA_Human4.03328070
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.96177672
8* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.52704783
9MYC_22102868_ChIP-Seq_BL_Human3.44851828
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.33700060
11STAT4_19710469_ChIP-ChIP_TH1__Mouse3.31278603
12RUNX_20019798_ChIP-Seq_JUKART_Human3.21352088
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.13180115
14ZNF274_21170338_ChIP-Seq_K562_Hela3.10715474
15BP1_19119308_ChIP-ChIP_Hs578T_Human3.08216323
16* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.07172903
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.98543271
18* MYB_26560356_Chip-Seq_TH2_Human2.84681835
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.64344016
20* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.61856990
21* MAF_26560356_Chip-Seq_TH1_Human2.58017341
22* MYB_26560356_Chip-Seq_TH1_Human2.57166191
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.50009494
24VDR_22108803_ChIP-Seq_LS180_Human2.44417381
25* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.43594216
26NOTCH1_21737748_ChIP-Seq_TLL_Human2.35230987
27VDR_21846776_ChIP-Seq_THP-1_Human2.26711621
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.25168257
29UTX_26944678_Chip-Seq_JUKART_Human2.10753153
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.04331203
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.04229100
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.03216836
33SPI1_23547873_ChIP-Seq_NB4_Human2.02870315
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.02330855
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97936325
36EZH2_22144423_ChIP-Seq_EOC_Human1.87293720
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83840966
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.83134628
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.83117298
40MYB_21317192_ChIP-Seq_ERMYB_Mouse1.82750610
41VDR_24763502_ChIP-Seq_THP-1_Human1.77593881
42SCL_19346495_ChIP-Seq_HPC-7_Human1.77084307
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76366346
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.75808904
45* MAF_26560356_Chip-Seq_TH2_Human1.72978089
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.72241919
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.69642901
48GATA3_27048872_Chip-Seq_THYMUS_Human1.69529960
49BRD4_27068464_Chip-Seq_AML-cells_Mouse1.67987323
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.60955240
51TCF7_22412390_ChIP-Seq_EML_Mouse1.60659596
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.60266333
53IGF1R_20145208_ChIP-Seq_DFB_Human1.57607081
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55872211
55HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54729354
56BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.54163058
57KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.53940356
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53056185
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.51463782
60CIITA_25753668_ChIP-Seq_RAJI_Human1.51409272
61SPI1_23127762_ChIP-Seq_K562_Human1.50254535
62MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.46431029
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44674787
64IRF1_19129219_ChIP-ChIP_H3396_Human1.43444040
65* PU_27001747_Chip-Seq_BMDM_Mouse1.41628151
66ER_23166858_ChIP-Seq_MCF-7_Human1.36244803
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35880675
68BCAT_22108803_ChIP-Seq_LS180_Human1.31002412
69GATA3_26560356_Chip-Seq_TH2_Human1.28394957
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.28179356
71POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27816870
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27563127
73IKZF1_21737484_ChIP-ChIP_HCT116_Human1.27349182
74* EWS_26573619_Chip-Seq_HEK293_Human1.26582458
75GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26502001
76PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26056847
77EST1_17652178_ChIP-ChIP_JURKAT_Human1.25941850
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21636383
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.19802891
80KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18873739
81SMRT_27268052_Chip-Seq_Bcells_Human1.18759062
82VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.18738371
83PRDM14_20953172_ChIP-Seq_ESCs_Human1.17764015
84Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.17335604
85SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16910560
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16602615
87POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16602615
88SMAD_19615063_ChIP-ChIP_OVARY_Human1.16499691
89NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.16006333
90RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.15881464
91KDM2B_26808549_Chip-Seq_DND41_Human1.15800518
92CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15513208
93EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13941905
94FOXA1_25329375_ChIP-Seq_VCAP_Human1.12499361
95FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12499361
96GBX2_23144817_ChIP-Seq_PC3_Human1.11211885
97GATA3_21878914_ChIP-Seq_MCF-7_Human1.10834250
98HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09853610
99GABP_17652178_ChIP-ChIP_JURKAT_Human1.09820510
100FOXM1_23109430_ChIP-Seq_U2OS_Human1.09742132
101TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.08744670
102* TP53_22573176_ChIP-Seq_HFKS_Human1.07650747
103MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07257934
104GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06576698
105EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06568938
106FUS_26573619_Chip-Seq_HEK293_Human1.06225450
107E2F4_17652178_ChIP-ChIP_JURKAT_Human1.04809301
108* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03235137
109* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02912091
110P300_19829295_ChIP-Seq_ESCs_Human1.02552924
111LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01904656
112STAT3_23295773_ChIP-Seq_U87_Human1.01384207
113CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.00868544
114TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00769410
115UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00360542
116MYC_18940864_ChIP-ChIP_HL60_Human1.00070732
117* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98176910
118* EZH2_27294783_Chip-Seq_NPCs_Mouse0.97990914
119PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97737960
120EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.97721449
121AR_21572438_ChIP-Seq_LNCaP_Human0.97313776
122STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96082979
123ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95807920
124RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95633442
125CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95617552
126TAF15_26573619_Chip-Seq_HEK293_Human0.94964575
127CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93928217
128NCOR_22424771_ChIP-Seq_293T_Human0.93810689
129VDR_24787735_ChIP-Seq_THP-1_Human0.93770104
130PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93536924
131CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93321651
132SOX2_19829295_ChIP-Seq_ESCs_Human0.92066572
133NANOG_19829295_ChIP-Seq_ESCs_Human0.92066572
134* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92022313
135STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91615279
136IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91289143
137CBP_20019798_ChIP-Seq_JUKART_Human0.91289143
138TP63_19390658_ChIP-ChIP_HaCaT_Human0.91278985
139GATA1_22025678_ChIP-Seq_K562_Human0.89376911
140HOXB4_20404135_ChIP-ChIP_EML_Mouse0.88368426
141VDR_23849224_ChIP-Seq_CD4+_Human0.87552211
142SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85938299
143ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85329971
144GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84951171
145* FOXP3_21729870_ChIP-Seq_TREG_Human0.83549932
146PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80813990
147TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.79142908
148CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78651578
149LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.78350613
150GATA1_19941827_ChIP-Seq_MEL_Mouse0.75992299
151GATA3_26560356_Chip-Seq_TH1_Human0.73787965
152SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.71587281
153FLI1_27457419_Chip-Seq_LIVER_Mouse0.69954113
154GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.69624911
155PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.69215325
156PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.68092010
157ELK3_25401928_ChIP-Seq_HUVEC_Human0.66851002
158NCOR1_26117541_ChIP-Seq_K562_Human0.66067216
159KDM2B_26808549_Chip-Seq_JURKAT_Human0.65579713
160FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65323622
161THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.65091875
162ELK1_19687146_ChIP-ChIP_HELA_Human0.63625757
163ETS1_22383799_ChIP-Seq_G1ME_Mouse0.63006802
164KDM5A_27292631_Chip-Seq_BREAST_Human0.62678325

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.74590639
2MP0001790_abnormal_immune_system4.06544782
3MP0005387_immune_system_phenotype4.06544782
4MP0001800_abnormal_humoral_immune3.95107810
5MP0003763_abnormal_thymus_physiology3.81889953
6MP0005671_abnormal_response_to3.80103868
7MP0000685_abnormal_immune_system3.61127464
8MP0005000_abnormal_immune_tolerance3.21486736
9MP0002452_abnormal_antigen_presenting3.17978967
10MP0003436_decreased_susceptibility_to3.07701558
11MP0002723_abnormal_immune_serum3.02306209
12MP0002420_abnormal_adaptive_immunity2.90247876
13MP0001819_abnormal_immune_cell2.85785537
14MP0009785_altered_susceptibility_to2.73447030
15MP0002398_abnormal_bone_marrow2.69537100
16MP0005025_abnormal_response_to2.52823199
17MP0003303_peritoneal_inflammation2.45291982
18MP0000716_abnormal_immune_system2.44936480
19MP0001873_stomach_inflammation2.43635942
20MP0002148_abnormal_hypersensitivity_rea2.37975952
21MP0002396_abnormal_hematopoietic_system2.35606651
22MP0002405_respiratory_system_inflammati2.32296854
23MP0000689_abnormal_spleen_morphology2.30574814
24MP0002166_altered_tumor_susceptibility2.27808538
25MP0009333_abnormal_splenocyte_physiolog2.27649208
26MP0002419_abnormal_innate_immunity2.21728137
27MP0010155_abnormal_intestine_physiology2.17240017
28MP0001986_abnormal_taste_sensitivity2.16134421
29MP0003300_gastrointestinal_ulcer2.14326733
30MP0002722_abnormal_immune_system2.09798814
31MP0003866_abnormal_defecation2.08865838
32MP0006082_CNS_inflammation2.04541252
33MP0002429_abnormal_blood_cell2.00198245
34MP0004510_myositis1.99006168
35MP0000703_abnormal_thymus_morphology1.98731834
36MP0002006_tumorigenesis1.91054503
37MP0008877_abnormal_DNA_methylation1.90742109
38MP0002933_joint_inflammation1.88834610
39MP0001845_abnormal_inflammatory_respons1.81850188
40MP0005310_abnormal_salivary_gland1.78123744
41MP0001853_heart_inflammation1.74487067
42MP0004947_skin_inflammation1.70870768
43MP0005464_abnormal_platelet_physiology1.59607467
44MP0003724_increased_susceptibility_to1.57477393
45MP0005645_abnormal_hypothalamus_physiol1.46950917
46MP0003195_calcinosis1.45379671
47MP0008872_abnormal_physiological_respon1.45317074
48MP0004808_abnormal_hematopoietic_stem1.43469611
49MP0002102_abnormal_ear_morphology1.43419547
50MP0008057_abnormal_DNA_replication1.39792946
51MP0004142_abnormal_muscle_tone1.33645661
52MP0000372_irregular_coat_pigmentation1.31868657
53MP0008469_abnormal_protein_level1.24955123
54MP0001533_abnormal_skeleton_physiology1.22943801
55MP0005551_abnormal_eye_electrophysiolog1.22124818
56MP0003646_muscle_fatigue1.21450526
57MP0000465_gastrointestinal_hemorrhage1.17310205
58MP0001501_abnormal_sleep_pattern1.14962333
59MP0000490_abnormal_crypts_of1.14207503
60MP0002138_abnormal_hepatobiliary_system1.10214791
61MP0005379_endocrine/exocrine_gland_phen1.05690244
62MP0003448_altered_tumor_morphology1.05271337
63MP0009764_decreased_sensitivity_to1.05009403
64MP0000569_abnormal_digit_pigmentation1.04047054
65MP0001968_abnormal_touch/_nociception1.03027727
66MP0000858_altered_metastatic_potential1.01650515
67MP0004742_abnormal_vestibular_system1.01185306
68MP0002876_abnormal_thyroid_physiology0.97345410
69MP0001545_abnormal_hematopoietic_system0.95941998
70MP0005397_hematopoietic_system_phenotyp0.95941998
71MP0002638_abnormal_pupillary_reflex0.95358741
72MP0002019_abnormal_tumor_incidence0.93982821
73MP0009745_abnormal_behavioral_response0.91313383
74MP0003183_abnormal_peptide_metabolism0.88503559
75MP0005167_abnormal_blood-brain_barrier0.87018886
76MP0005451_abnormal_body_composition0.84187759
77MP0005076_abnormal_cell_differentiation0.84156737
78MP0010307_abnormal_tumor_latency0.83202305
79MP0005174_abnormal_tail_pigmentation0.82996437
80MP0005084_abnormal_gallbladder_morpholo0.82620873
81MP0002998_abnormal_bone_remodeling0.81762577
82MP0004381_abnormal_hair_follicle0.80633403
83MP0004043_abnormal_pH_regulation0.80579561
84MP0002277_abnormal_respiratory_mucosa0.79873018
85MP0001919_abnormal_reproductive_system0.79692957
86MP0001485_abnormal_pinna_reflex0.78630908
87MP0010094_abnormal_chromosome_stability0.78620383
88MP0008875_abnormal_xenobiotic_pharmacok0.76958276
89MP0003252_abnormal_bile_duct0.76801940
90MP0003077_abnormal_cell_cycle0.76086813
91MP0008995_early_reproductive_senescence0.75272932
92MP0000427_abnormal_hair_cycle0.75220503
93MP0003045_fibrosis0.74386739
94MP0010352_gastrointestinal_tract_polyps0.72407705
95MP0001663_abnormal_digestive_system0.71769255
96MP0005253_abnormal_eye_physiology0.71544668
97MP0002095_abnormal_skin_pigmentation0.71200936
98MP0000015_abnormal_ear_pigmentation0.70368475
99MP0005075_abnormal_melanosome_morpholog0.70100548
100MP0003136_yellow_coat_color0.70024292
101MP0003172_abnormal_lysosome_physiology0.69970160
102MP0002254_reproductive_system_inflammat0.69921136
103MP0009278_abnormal_bone_marrow0.69095430
104MP0002653_abnormal_ependyma_morphology0.68663553
105MP0003787_abnormal_imprinting0.68052189
106MP0009046_muscle_twitch0.67826604
107MP0003693_abnormal_embryo_hatching0.67804407
108MP0004885_abnormal_endolymph0.67773804
109MP0003011_delayed_dark_adaptation0.67635908
110MP0002009_preneoplasia0.67599012
111MP0002837_dystrophic_cardiac_calcinosis0.66201331
112MP0006072_abnormal_retinal_apoptosis0.65723073
113MP0008007_abnormal_cellular_replicative0.64863995
114MP0005448_abnormal_energy_balance0.64199232
115MP0002136_abnormal_kidney_physiology0.63973645
116MP0005381_digestive/alimentary_phenotyp0.63143567
117MP0002735_abnormal_chemical_nociception0.63055704
118MP0003111_abnormal_nucleus_morphology0.61972608
119MP0002132_abnormal_respiratory_system0.61587042
120MP0001851_eye_inflammation0.61428952
121MP0009763_increased_sensitivity_to0.60201611
122MP0005166_decreased_susceptibility_to0.58671508
123MP0008058_abnormal_DNA_repair0.56725155
124MP0009765_abnormal_xenobiotic_induced0.55503764
125MP0000609_abnormal_liver_physiology0.55404561
126MP0002163_abnormal_gland_morphology0.52418890
127MP0008961_abnormal_basal_metabolism0.51760471
128MP0003795_abnormal_bone_structure0.50022414
129MP0001881_abnormal_mammary_gland0.49168189
130MP0003091_abnormal_cell_migration0.48677592
131MP0000313_abnormal_cell_death0.47897924
132MP0002928_abnormal_bile_duct0.46927259
133MP0001191_abnormal_skin_condition0.46673507
134MP0003453_abnormal_keratinocyte_physiol0.46416308
135MP0001348_abnormal_lacrimal_gland0.46053187
136MP0004782_abnormal_surfactant_physiolog0.45476547
137MP0000371_diluted_coat_color0.45413517
138MP0005390_skeleton_phenotype0.44384279
139MP0000249_abnormal_blood_vessel0.44205327
140MP0002693_abnormal_pancreas_physiology0.42817240

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)5.26953703
2Recurrent bronchitis (HP:0002837)5.10565267
3Recurrent viral infections (HP:0004429)4.92740231
4Recurrent fungal infections (HP:0002841)4.88029869
5Chronic otitis media (HP:0000389)4.73499146
6Panhypogammaglobulinemia (HP:0003139)4.71545148
7T lymphocytopenia (HP:0005403)4.62744649
8Abnormality of T cell number (HP:0011839)4.56678728
9Eczematoid dermatitis (HP:0000976)4.53069536
10IgM deficiency (HP:0002850)4.51280988
11Chronic mucocutaneous candidiasis (HP:0002728)4.47836929
12Recurrent cutaneous fungal infections (HP:0011370)4.47836929
13Abnormal delayed hypersensitivity skin test (HP:0002963)4.45925673
14Inflammation of the large intestine (HP:0002037)4.19497136
15Chronic diarrhea (HP:0002028)4.16655933
16Elevated erythrocyte sedimentation rate (HP:0003565)4.13789123
17Recurrent sinusitis (HP:0011108)4.11181600
18Gastrointestinal stroma tumor (HP:0100723)4.08459956
19Meningitis (HP:0001287)4.03513936
20Myositis (HP:0100614)4.01028873
21Gastrointestinal inflammation (HP:0004386)3.98712400
22Vasculitis (HP:0002633)3.92903996
23Abnormality of T cells (HP:0002843)3.92848168
24Recurrent abscess formation (HP:0002722)3.89000069
25IgA deficiency (HP:0002720)3.82942856
26Abnormality of B cell number (HP:0010975)3.74636414
27B lymphocytopenia (HP:0010976)3.74636414
28Optic neuritis (HP:0100653)3.73457527
29Retrobulbar optic neuritis (HP:0100654)3.73457527
30Lymphopenia (HP:0001888)3.72152100
31Congenital stationary night blindness (HP:0007642)3.69792440
32Chronic sinusitis (HP:0011109)3.65931760
33Stomatitis (HP:0010280)3.63666432
34Abnormality of cells of the lymphoid lineage (HP:0012140)3.58702960
35Colitis (HP:0002583)3.57819949
36IgG deficiency (HP:0004315)3.55479395
37Nasal polyposis (HP:0100582)3.54906823
38Pancreatic cysts (HP:0001737)3.54066583
39Cellulitis (HP:0100658)3.50723210
40Mediastinal lymphadenopathy (HP:0100721)3.49554947
41Abnormality of the fingertips (HP:0001211)3.42621288
42Recurrent bacterial skin infections (HP:0005406)3.41737606
43Severe combined immunodeficiency (HP:0004430)3.28385030
44Recurrent skin infections (HP:0001581)3.27186174
45Orchitis (HP:0100796)3.26946070
46Abnormality of T cell physiology (HP:0011840)3.26089472
47Autoimmune thrombocytopenia (HP:0001973)3.23036570
48Pulmonary infiltrates (HP:0002113)3.21927977
49Pustule (HP:0200039)3.17685688
50Combined immunodeficiency (HP:0005387)3.13470270
51Emphysema (HP:0002097)3.12763374
52Verrucae (HP:0200043)3.09339478
53Papilloma (HP:0012740)3.09339478
54Chronic obstructive pulmonary disease (HP:0006510)3.04811150
55Obstructive lung disease (HP:0006536)3.04811150
56Recurrent pneumonia (HP:0006532)3.01493627
57Molar tooth sign on MRI (HP:0002419)2.96842990
58Abnormality of midbrain morphology (HP:0002418)2.96842990
59Encephalitis (HP:0002383)2.91612124
60Abnormality of the renal cortex (HP:0011035)2.86486030
61Eosinophilia (HP:0001880)2.84467499
62Thyroiditis (HP:0100646)2.82528025
63Pancreatic fibrosis (HP:0100732)2.81687077
64Abnormality of the nasal mucosa (HP:0000433)2.80111368
65Hemoptysis (HP:0002105)2.80022486
66Cheilitis (HP:0100825)2.78737810
67Recurrent lower respiratory tract infections (HP:0002783)2.76095034
68Bronchitis (HP:0012387)2.74216801
69Lymphoma (HP:0002665)2.72473295
70True hermaphroditism (HP:0010459)2.71551637
71Osteomyelitis (HP:0002754)2.63809512
72Increased IgE level (HP:0003212)2.63478984
73Arterial thrombosis (HP:0004420)2.54758107
74Granulocytopenia (HP:0001913)2.53460042
75Abnormality of eosinophils (HP:0001879)2.51083151
76Leukocytosis (HP:0001974)2.50725960
77Joint swelling (HP:0001386)2.49064827
78Gastrointestinal infarctions (HP:0005244)2.48965956
79Keratoconjunctivitis sicca (HP:0001097)2.48150437
80Attenuation of retinal blood vessels (HP:0007843)2.43717002
81Thrombocytosis (HP:0001894)2.42581778
82Recurrent otitis media (HP:0000403)2.42518371
83Abnormality of the prostate (HP:0008775)2.41522926
84Nephronophthisis (HP:0000090)2.35996276
85Abnormality of the renal medulla (HP:0100957)2.33962405
86Increased IgM level (HP:0003496)2.33568823
87Restrictive lung disease (HP:0002091)2.33463641
88Recurrent gram-negative bacterial infections (HP:0005420)2.32991069
89Spontaneous hematomas (HP:0007420)2.32930688
90Abnormality of macrophages (HP:0004311)2.31559986
91Keratoconjunctivitis (HP:0001096)2.29461769
92Leukopenia (HP:0001882)2.28620121
93Chronic hepatic failure (HP:0100626)2.28212289
94Abnormal rod and cone electroretinograms (HP:0008323)2.26112769
95Stomach cancer (HP:0012126)2.23152329
96Autoimmune hemolytic anemia (HP:0001890)2.23016540
97Gingivitis (HP:0000230)2.20808436
98Periodontitis (HP:0000704)2.19384055
99Abolished electroretinogram (ERG) (HP:0000550)2.16637315
100Skin ulcer (HP:0200042)2.15797040
101Congenital, generalized hypertrichosis (HP:0004540)2.12287691
102Chest pain (HP:0100749)2.10851589
103Skin rash (HP:0000988)2.10840161
104Polydipsia (HP:0001959)2.09942700
105Abnormal drinking behavior (HP:0030082)2.09942700
106Arthralgia (HP:0002829)2.07775802
107Myocardial infarction (HP:0001658)2.07341763
108Hypergammaglobulinemia (HP:0010702)2.06458219
109Sepsis (HP:0100806)2.06406517
110Hyperventilation (HP:0002883)2.06228555
111Genetic anticipation (HP:0003743)2.03102821
112Renal cortical cysts (HP:0000803)2.02704544
113Large for gestational age (HP:0001520)1.98894069
114Cystic liver disease (HP:0006706)1.97897208
115Gingival bleeding (HP:0000225)1.97649729
116Type II lissencephaly (HP:0007260)1.97290302
117Hypochromic anemia (HP:0001931)1.97123435
118Interstitial pulmonary disease (HP:0006530)1.96640910
119Inability to walk (HP:0002540)1.92261508
120Bile duct proliferation (HP:0001408)1.91836679
121Abnormal biliary tract physiology (HP:0012439)1.91836679
122Progressive cerebellar ataxia (HP:0002073)1.91539379
123Aplasia/Hypoplasia of the spleen (HP:0010451)1.91483075
124Tubular atrophy (HP:0000092)1.91442998
125Clumsiness (HP:0002312)1.90658852
126Progressive inability to walk (HP:0002505)1.90016677
127Absent rod-and cone-mediated responses on ERG (HP:0007688)1.87545881
128Pulmonary embolism (HP:0002204)1.87076570
129Abnormality of the pleura (HP:0002103)1.86740917
130Neutropenia (HP:0001875)1.85179289
131Hepatitis (HP:0012115)1.84431199
132Oligodactyly (hands) (HP:0001180)1.79714465
133Hypoplasia of the thymus (HP:0000778)1.79039197
134Pendular nystagmus (HP:0012043)1.78792498
135Gaze-evoked nystagmus (HP:0000640)1.77905226
136Bronchiectasis (HP:0002110)1.77864850
137Basal cell carcinoma (HP:0002671)1.77842469
138Concave nail (HP:0001598)1.77465388
139Decreased circulating renin level (HP:0003351)1.77304945
140Constricted visual fields (HP:0001133)1.75988836
141Polyuria (HP:0000103)1.75254604
142Fair hair (HP:0002286)1.74996530
143Furrowed tongue (HP:0000221)1.74176570

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K16.04695719
2FRK3.94197887
3TXK3.79781585
4MAP3K143.51220065
5JAK33.41434640
6TYK23.08672144
7ITK2.45557524
8FGFR42.41853074
9IKBKE2.38581768
10ZAP702.29292049
11TLK12.29207209
12JAK12.20351312
13IRAK42.06537761
14SYK2.05594112
15STK101.95103085
16BLK1.87666419
17IKBKB1.87486799
18MAP3K131.87227168
19SIK21.85874340
20FGFR31.85471819
21TBK11.85058642
22GRK61.83657377
23TEC1.81819328
24KIT1.81508485
25BTK1.78944580
26SIK31.74244847
27CAMKK21.73877133
28EEF2K1.70400502
29IRAK31.66365308
30LCK1.64631211
31ACVR1B1.63901218
32CSF1R1.63609350
33WNK41.62928160
34HCK1.61043847
35ZAK1.53485014
36BMPR1B1.51437559
37NLK1.51427259
38CSK1.46319727
39CHUK1.43153981
40MAP4K21.39987207
41CDK121.39175575
42EPHA31.32760674
43MAP2K61.31287250
44PRKCQ1.25062534
45MAPK131.23898198
46WNK31.23202642
47LYN1.20286704
48CLK11.16491894
49MAP3K101.11326294
50MARK31.10704386
51STK391.10702068
52EPHB11.09343214
53INSRR1.07928990
54MST41.07323461
55ERN11.06905076
56PIM11.06758044
57FES1.01014033
58OXSR10.98212608
59PRKCH0.98167579
60BRD40.94278129
61TGFBR10.91981299
62RIPK40.91262079
63SIK10.89171705
64CCNB10.83916762
65CAMKK10.82560385
66JAK20.81241034
67VRK10.81110235
68TAOK30.80749986
69LRRK20.79002114
70MAPK150.78967308
71DAPK20.78589290
72NME20.77608691
73ADRBK10.77573094
74STK240.74900597
75RPS6KA40.72812233
76TNK20.72502288
77STK110.70576200
78PINK10.68801020
79MAP3K70.67486485
80PIK3CG0.67225557
81IRAK10.61939222
82CDK40.58749735
83ALK0.57555994
84SGK30.57369761
85MAP3K40.56978059
86STK40.53552287
87PTK2B0.53253444
88TGFBR20.52357142
89GRK70.49644652
90MKNK20.49524223
91FGFR20.49251604
92MAP2K30.48898998
93TAOK20.47280922
94CDK190.46058524
95PRPF4B0.45836299
96CDK90.45748049
97HIPK20.45583488
98CAMK40.44139587
99ABL10.42910487
100RPS6KA60.42514054
101EGFR0.42496698
102SGK20.42281290
103KDR0.41428763
104MAPK70.40858903
105MAPK120.40756949
106TSSK60.40524671
107UHMK10.39947795
108PIM20.39738858
109NUAK10.38880948
110ATR0.37876178
111MAPKAPK30.37681490
112MAPK110.37107763
113INSR0.36694958
114TAOK10.35522141
115BMPR20.35521756
116TYRO30.35344272
117NEK90.34987609
118PAK30.34019887
119EIF2AK30.33923013
120EIF2AK20.33627050
121NTRK20.33555867
122IGF1R0.33261021
123MAP3K110.32284032
124DYRK20.32260048
125TNIK0.32254558
126PTK60.31810633
127PASK0.30811466
128PDK10.30487253
129MAPKAPK20.29491063
130MELK0.29246823
131NEK20.29065572
132CAMK10.28917170
133MAPK30.28250414
134CDK60.27302056
135RPS6KA50.26691070
136FYN0.26350866
137FLT30.25221254
138MAP3K80.24958584
139MARK20.24590127
140PRKCD0.23870262
141GRK10.23121471
142PDGFRB0.22587899
143PKN20.21809029
144ADRBK20.21630915

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.44333433
2NF-kappa B signaling pathway_Homo sapiens_hsa040643.27218650
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.26373055
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.17754709
5B cell receptor signaling pathway_Homo sapiens_hsa046622.99746040
6T cell receptor signaling pathway_Homo sapiens_hsa046602.81885972
7Measles_Homo sapiens_hsa051622.76408742
8Allograft rejection_Homo sapiens_hsa053302.48314588
9Leishmaniasis_Homo sapiens_hsa051402.38286862
10Antigen processing and presentation_Homo sapiens_hsa046122.23284558
11Hematopoietic cell lineage_Homo sapiens_hsa046402.22279055
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.21574677
13Graft-versus-host disease_Homo sapiens_hsa053322.21384088
14Osteoclast differentiation_Homo sapiens_hsa043802.19219590
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.92843464
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.90926910
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.90584526
18Herpes simplex infection_Homo sapiens_hsa051681.85512432
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.84708728
20Linoleic acid metabolism_Homo sapiens_hsa005911.81462471
21Phototransduction_Homo sapiens_hsa047441.80790249
22Autoimmune thyroid disease_Homo sapiens_hsa053201.73287340
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.66360008
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.55138304
25Influenza A_Homo sapiens_hsa051641.54024610
26Viral myocarditis_Homo sapiens_hsa054161.45703323
27Toxoplasmosis_Homo sapiens_hsa051451.45036745
28Type I diabetes mellitus_Homo sapiens_hsa049401.40445957
29Chemokine signaling pathway_Homo sapiens_hsa040621.36246147
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.36045275
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.34461361
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.33669135
33Hepatitis B_Homo sapiens_hsa051611.32217851
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.29489863
35TNF signaling pathway_Homo sapiens_hsa046681.28782374
36Tuberculosis_Homo sapiens_hsa051521.27284043
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.26944129
38Staphylococcus aureus infection_Homo sapiens_hsa051501.26752133
39Acute myeloid leukemia_Homo sapiens_hsa052211.20811146
40Ether lipid metabolism_Homo sapiens_hsa005651.20574372
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.19951256
42Apoptosis_Homo sapiens_hsa042101.17150754
43Nitrogen metabolism_Homo sapiens_hsa009101.15244313
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15126563
45Legionellosis_Homo sapiens_hsa051341.13322081
46Shigellosis_Homo sapiens_hsa051311.06241109
47Epstein-Barr virus infection_Homo sapiens_hsa051691.05985775
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05882536
49Non-homologous end-joining_Homo sapiens_hsa034501.03994116
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03880416
51Asthma_Homo sapiens_hsa053101.03369506
52Hepatitis C_Homo sapiens_hsa051601.03093887
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.00036103
54Malaria_Homo sapiens_hsa051440.98261285
55Pertussis_Homo sapiens_hsa051330.97918257
56HTLV-I infection_Homo sapiens_hsa051660.94478399
57RNA polymerase_Homo sapiens_hsa030200.94259584
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.94067558
59Chronic myeloid leukemia_Homo sapiens_hsa052200.93674748
60Butanoate metabolism_Homo sapiens_hsa006500.92312414
61Prolactin signaling pathway_Homo sapiens_hsa049170.90814352
62Base excision repair_Homo sapiens_hsa034100.89468262
63Pancreatic cancer_Homo sapiens_hsa052120.89283041
64Systemic lupus erythematosus_Homo sapiens_hsa053220.87555838
65Viral carcinogenesis_Homo sapiens_hsa052030.82752357
66Ribosome_Homo sapiens_hsa030100.79510749
67Oxidative phosphorylation_Homo sapiens_hsa001900.78979428
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.77551527
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74638891
70Rheumatoid arthritis_Homo sapiens_hsa053230.73914369
71Tryptophan metabolism_Homo sapiens_hsa003800.71533257
72Regulation of autophagy_Homo sapiens_hsa041400.70694275
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69812686
74One carbon pool by folate_Homo sapiens_hsa006700.68165813
75Basal transcription factors_Homo sapiens_hsa030220.67663685
76African trypanosomiasis_Homo sapiens_hsa051430.66677037
77Selenocompound metabolism_Homo sapiens_hsa004500.65981988
78Morphine addiction_Homo sapiens_hsa050320.65334109
79Salmonella infection_Homo sapiens_hsa051320.63699849
80Taste transduction_Homo sapiens_hsa047420.63036443
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62496073
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62410573
83Nicotine addiction_Homo sapiens_hsa050330.59042506
84Small cell lung cancer_Homo sapiens_hsa052220.58884093
85p53 signaling pathway_Homo sapiens_hsa041150.57343715
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57262929
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.57250309
88Dorso-ventral axis formation_Homo sapiens_hsa043200.57113650
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56487047
90Olfactory transduction_Homo sapiens_hsa047400.56147051
91Non-small cell lung cancer_Homo sapiens_hsa052230.55631284
92Arachidonic acid metabolism_Homo sapiens_hsa005900.55414812
93DNA replication_Homo sapiens_hsa030300.52078355
94Platelet activation_Homo sapiens_hsa046110.51790745
95Parkinsons disease_Homo sapiens_hsa050120.51608060
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51489175
97Mismatch repair_Homo sapiens_hsa034300.51444555
98Glycerolipid metabolism_Homo sapiens_hsa005610.50663435
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50338703
100Protein export_Homo sapiens_hsa030600.49606758
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48227375
102HIF-1 signaling pathway_Homo sapiens_hsa040660.47410766
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46742266
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45432314
105Notch signaling pathway_Homo sapiens_hsa043300.44457890
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43443940
107Homologous recombination_Homo sapiens_hsa034400.42006863
108Fanconi anemia pathway_Homo sapiens_hsa034600.41856739
109Inositol phosphate metabolism_Homo sapiens_hsa005620.41080559
110Lysine degradation_Homo sapiens_hsa003100.40542817
111MAPK signaling pathway_Homo sapiens_hsa040100.40313516
112Colorectal cancer_Homo sapiens_hsa052100.40177325
113Spliceosome_Homo sapiens_hsa030400.39574718
114Serotonergic synapse_Homo sapiens_hsa047260.39359762
115RNA degradation_Homo sapiens_hsa030180.39007337
116Prostate cancer_Homo sapiens_hsa052150.38321683
117MicroRNAs in cancer_Homo sapiens_hsa052060.37574083
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.37392850
119FoxO signaling pathway_Homo sapiens_hsa040680.36999812
120Other glycan degradation_Homo sapiens_hsa005110.35052136
121VEGF signaling pathway_Homo sapiens_hsa043700.33408183
122Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.32923380
123Glycosaminoglycan degradation_Homo sapiens_hsa005310.32093077
124Caffeine metabolism_Homo sapiens_hsa002320.31736913
125Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30141791
126Peroxisome_Homo sapiens_hsa041460.30005034
127Ovarian steroidogenesis_Homo sapiens_hsa049130.29019502
128ABC transporters_Homo sapiens_hsa020100.27976310
129Insulin resistance_Homo sapiens_hsa049310.27267187
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.24644375
131Regulation of actin cytoskeleton_Homo sapiens_hsa048100.24454384
132Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.22588609
133mTOR signaling pathway_Homo sapiens_hsa041500.21890420
134Calcium signaling pathway_Homo sapiens_hsa040200.21479799
135Renal cell carcinoma_Homo sapiens_hsa052110.21412780
136Primary bile acid biosynthesis_Homo sapiens_hsa001200.21310323
137Collecting duct acid secretion_Homo sapiens_hsa049660.20989575
138mRNA surveillance pathway_Homo sapiens_hsa030150.20493078
139Steroid hormone biosynthesis_Homo sapiens_hsa001400.20248999
140Endocytosis_Homo sapiens_hsa041440.19549896
141Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19355852
142Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18177052
143Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.18057841
144Cholinergic synapse_Homo sapiens_hsa047250.16960599
145Huntingtons disease_Homo sapiens_hsa050160.16602244
146Pathways in cancer_Homo sapiens_hsa052000.16599097
147Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.15386120

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