ZC3H12A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ZC3H12A is an MCP1 (CCL2; MIM 158105)-induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.10797581
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.10797581
3positive regulation by organism of defense response of other organism involved in symbiotic interact5.10797581
4modulation by symbiont of host immune response (GO:0052553)5.10797581
5positive regulation by symbiont of host defense response (GO:0052509)5.10797581
6modulation by symbiont of host defense response (GO:0052031)5.10797581
7response to muramyl dipeptide (GO:0032495)4.61832837
8regulation of vitamin metabolic process (GO:0030656)4.57509642
9positive regulation of gamma-delta T cell activation (GO:0046645)4.55848015
10response to peptidoglycan (GO:0032494)4.46035016
11NIK/NF-kappaB signaling (GO:0038061)4.36248265
12regulation of T-helper 1 cell differentiation (GO:0045625)4.19768938
13neutrophil activation involved in immune response (GO:0002283)4.16749635
14positive regulation of heat generation (GO:0031652)4.01760560
15leukocyte aggregation (GO:0070486)3.98667182
16regulation of interleukin-12 biosynthetic process (GO:0045075)3.97108166
17macrophage activation involved in immune response (GO:0002281)3.83604878
18positive regulation of chemokine biosynthetic process (GO:0045080)3.80369992
19regulation of fever generation (GO:0031620)3.80345090
20regulation of gamma-delta T cell activation (GO:0046643)3.74869019
21immunoglobulin mediated immune response (GO:0016064)3.70800396
22regulation of cytokine secretion involved in immune response (GO:0002739)3.69620785
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.67796658
24negative regulation of interleukin-12 production (GO:0032695)3.64227452
25T-helper 1 type immune response (GO:0042088)3.63012188
26granulocyte activation (GO:0036230)3.59470918
27positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.59305051
28tolerance induction (GO:0002507)3.56333703
29lipopolysaccharide-mediated signaling pathway (GO:0031663)3.51459802
30antigen processing and presentation of endogenous antigen (GO:0019883)3.51092754
31antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.48816724
32antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.48816724
33neutrophil activation (GO:0042119)3.48621463
34positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.48155665
35regulation of gamma-delta T cell differentiation (GO:0045586)3.47436600
36positive regulation of interferon-alpha production (GO:0032727)3.46625253
37positive regulation of type 2 immune response (GO:0002830)3.44515648
38regulation of interferon-alpha production (GO:0032647)3.41869453
39negative regulation of cytokine production involved in immune response (GO:0002719)3.41561511
40negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.41551785
41regulation of T-helper 2 cell differentiation (GO:0045628)3.40706366
42response to host immune response (GO:0052572)3.39920574
43response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.39920574
44regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.37854418
45regulation of chronic inflammatory response (GO:0002676)3.36087997
46positive regulation of antigen processing and presentation (GO:0002579)3.34054137
47myeloid dendritic cell differentiation (GO:0043011)3.31455181
48myeloid dendritic cell activation (GO:0001773)3.28250797
49interferon-gamma-mediated signaling pathway (GO:0060333)3.27520412
50regulation of dendritic cell antigen processing and presentation (GO:0002604)3.27082375
51respiratory burst (GO:0045730)3.24126820
52regulation of interferon-beta biosynthetic process (GO:0045357)3.22835708
53germinal center formation (GO:0002467)3.20474404
54branching involved in labyrinthine layer morphogenesis (GO:0060670)3.19914737
55regulation of membrane protein ectodomain proteolysis (GO:0051043)3.19396847
56activation of MAPKKK activity (GO:0000185)3.17683011
57response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.15770754
58response to host (GO:0075136)3.15770754
59response to host defenses (GO:0052200)3.15770754
60regulation of B cell receptor signaling pathway (GO:0050855)3.15708827
61response to type I interferon (GO:0034340)3.14792322
62type I interferon signaling pathway (GO:0060337)3.13682544
63cellular response to type I interferon (GO:0071357)3.13682544
64interferon-gamma production (GO:0032609)3.12122747
65negative regulation of cell killing (GO:0031342)3.11559296
66negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.11559296
67myeloid cell activation involved in immune response (GO:0002275)3.06577293
68positive thymic T cell selection (GO:0045059)3.06493686
69regulation of chemokine biosynthetic process (GO:0045073)3.06082358
70JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.04959759
71detection of other organism (GO:0098543)3.03493668
72positive regulation of interleukin-12 production (GO:0032735)3.02622828
73regulation of antigen processing and presentation (GO:0002577)3.02297439
74leukocyte cell-cell adhesion (GO:0007159)3.02254022
75modulation by symbiont of host cellular process (GO:0044068)3.01307766
76positive regulation of humoral immune response (GO:0002922)3.00973012
77regulation of interleukin-8 biosynthetic process (GO:0045414)3.00392038
78T cell migration (GO:0072678)2.99708737
79regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.99288148
80negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.99045017
81regulation of mononuclear cell migration (GO:0071675)2.98444928
82defense response to protozoan (GO:0042832)2.93760553
83positive regulation of acute inflammatory response (GO:0002675)2.92645173
84positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.92582295
85positive regulation of cytokine biosynthetic process (GO:0042108)2.92237575
86microglial cell activation (GO:0001774)2.92113652
87regulation of T-helper cell differentiation (GO:0045622)2.91722547
88regulation of interleukin-12 production (GO:0032655)2.90691336
89regulation of type I interferon-mediated signaling pathway (GO:0060338)2.90269229
90positive regulation of interferon-beta production (GO:0032728)2.89626719
91regulation of heat generation (GO:0031650)2.89171053
92regulation of podosome assembly (GO:0071801)2.88856277
93regulation of immunoglobulin secretion (GO:0051023)2.88820060
94regulation of vitamin D biosynthetic process (GO:0060556)2.88796206
95detection of bacterium (GO:0016045)2.88688230
96positive regulation of nitric oxide biosynthetic process (GO:0045429)2.87907737
97positive regulation of T-helper cell differentiation (GO:0045624)2.87801560
98positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.85726904
99* cellular response to lipopolysaccharide (GO:0071222)2.85392891
100response to protozoan (GO:0001562)2.85312914
101CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.84843394
102positive regulation of interleukin-2 production (GO:0032743)2.84405414
103regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.83424687
104regulation of type 2 immune response (GO:0002828)2.83417692
105positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.82745905
106mature B cell differentiation (GO:0002335)2.81316146
107B cell mediated immunity (GO:0019724)2.78305325
108positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.78275892
109macrophage activation (GO:0042116)2.78174898
110* cellular response to molecule of bacterial origin (GO:0071219)2.77972265
111cellular extravasation (GO:0045123)2.75358817
112negative regulation of lipid storage (GO:0010888)2.74400327
113cytokine secretion (GO:0050663)2.74051270
114positive regulation of immunoglobulin mediated immune response (GO:0002891)2.74024361
115positive regulation of B cell mediated immunity (GO:0002714)2.74024361
116regulation of NF-kappaB import into nucleus (GO:0042345)2.73912197
117positive regulation of interleukin-17 production (GO:0032740)2.73867651
118positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.73443485
119positive regulation of interleukin-6 production (GO:0032755)2.72657311
120positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.71326168
121monocyte chemotaxis (GO:0002548)2.71033702
122regulation of response to interferon-gamma (GO:0060330)2.70548029
123regulation of mast cell degranulation (GO:0043304)2.70322819
124negative regulation of production of molecular mediator of immune response (GO:0002701)2.70276015
125negative regulation of myeloid cell apoptotic process (GO:0033033)2.70162403
126positive regulation of NF-kappaB import into nucleus (GO:0042346)2.69265287
127detection of molecule of bacterial origin (GO:0032490)2.68554427
128mature B cell differentiation involved in immune response (GO:0002313)2.68502561
129regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.67598528
130myeloid leukocyte activation (GO:0002274)2.66705289
131regulation of interleukin-2 biosynthetic process (GO:0045076)2.66522380
132positive regulation of transcription factor import into nucleus (GO:0042993)2.65964980
133cellular response to interferon-gamma (GO:0071346)2.65261170
134T-helper cell differentiation (GO:0042093)2.64791719
135CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.64791719
136positive regulation of B cell differentiation (GO:0045579)2.64227833
137superoxide anion generation (GO:0042554)2.64204701
138regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.64059434
139positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.63440232
140negative regulation of erythrocyte differentiation (GO:0045647)2.63356066
141regulation of alpha-beta T cell proliferation (GO:0046640)2.63322637
142regulation of heterotypic cell-cell adhesion (GO:0034114)2.61469394

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.36591512
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.89666314
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.81839844
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.39602392
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.37538869
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.95512102
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.71597262
8* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.56041109
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.52103641
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.45231214
11TP63_17297297_ChIP-ChIP_HaCaT_Human3.44769522
12* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.24916252
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.24066414
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.10220941
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.07508976
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.01613005
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.86334825
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.70919356
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.64603544
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.64422907
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.36614631
22* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.28428127
23MYB_26560356_Chip-Seq_TH2_Human2.23395032
24RUNX_20019798_ChIP-Seq_JUKART_Human2.12921964
25BRD4_27068464_Chip-Seq_AML-cells_Mouse2.12019883
26* MAF_26560356_Chip-Seq_TH1_Human2.06516630
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.01115252
28SPI1_23547873_ChIP-Seq_NB4_Human1.99496350
29VDR_24763502_ChIP-Seq_THP-1_Human1.96901243
30MYC_22102868_ChIP-Seq_BL_Human1.96092172
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.91614759
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.88566449
33* VDR_21846776_ChIP-Seq_THP-1_Human1.88129953
34* MYB_26560356_Chip-Seq_TH1_Human1.86421622
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.81307718
36SCL_19346495_ChIP-Seq_HPC-7_Human1.78737544
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.75303022
38TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.68253065
39PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.64166122
40TCF7_22412390_ChIP-Seq_EML_Mouse1.63186160
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.62949097
42* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.62828182
43* UTX_26944678_Chip-Seq_JUKART_Human1.60591978
44STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.58477419
45* LXR_22292898_ChIP-Seq_THP-1_Human1.58360815
46PU_27001747_Chip-Seq_BMDM_Mouse1.54358163
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50705780
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50616595
49VDR_24787735_ChIP-Seq_THP-1_Human1.44486404
50SPI1_23127762_ChIP-Seq_K562_Human1.43337308
51CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.40767028
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.39968978
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39793162
54E2F7_22180533_ChIP-Seq_HELA_Human1.37684013
55CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35938921
56* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33312955
57* RACK7_27058665_Chip-Seq_MCF-7_Human1.30075430
58* ELK3_25401928_ChIP-Seq_HUVEC_Human1.28639202
59GATA3_27048872_Chip-Seq_THYMUS_Human1.26279535
60* MAF_26560356_Chip-Seq_TH2_Human1.26220049
61* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24518452
62PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24011314
63* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21967804
64NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.18464487
65* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.18392615
66* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.18341006
67FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.17848708
68* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17790046
69GATA1_19941826_ChIP-Seq_K562_Human1.16426790
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15882652
71* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14052897
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12929375
73CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12882576
74* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10520533
75* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.08961931
76* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.08961931
77* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08701457
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08643226
79GATA1_19941827_ChIP-Seq_MEL_Mouse1.08217949
80SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05762763
81CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05080683
82* KDM2B_26808549_Chip-Seq_JURKAT_Human1.04734227
83* KDM2B_26808549_Chip-Seq_DND41_Human1.03758159
84GATA3_26560356_Chip-Seq_TH2_Human1.02710110
85* KDM2B_26808549_Chip-Seq_K562_Human1.01860221
86GATA1_22025678_ChIP-Seq_K562_Human1.01152903
87GATA2_21666600_ChIP-Seq_HMVEC_Human1.00883917
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00618377
89PPARA_22158963_ChIP-Seq_LIVER_Mouse0.99291618
90RXR_22158963_ChIP-Seq_LIVER_Mouse0.98315759
91LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.97594930
92CLOCK_20551151_ChIP-Seq_293T_Human0.96270897
93PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95605961
94BCOR_27268052_Chip-Seq_Bcells_Human0.95201458
95RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94712127
96HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94125287
97* UBF1/2_26484160_Chip-Seq_HMECs_Human0.93925333
98PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.92888561
99GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91898922
100* ATF3_27146783_Chip-Seq_COLON_Human0.91675517
101* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91150782
102SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91117594
103GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89111487
104* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87728064
105TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.85996249
106* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.85850738
107* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85723154
108FOXO3_23340844_ChIP-Seq_DLD1_Human0.83733426
109EGR1_19032775_ChIP-ChIP_M12_Human0.83340087
110NCOR1_26117541_ChIP-Seq_K562_Human0.82289856
111* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.81001471
112* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77103644
113TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.76737785
114GATA2_19941826_ChIP-Seq_K562_Human0.76623599
115ESR1_21235772_ChIP-Seq_MCF-7_Human0.76024997
116LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.75020745
117PU.1_20513432_ChIP-Seq_Bcells_Mouse0.74657347
118P63_26484246_Chip-Seq_KERATINOCYTES_Human0.74074128
119* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.73675975
120TFEB_21752829_ChIP-Seq_HELA_Human0.72534395
121RARG_19884340_ChIP-ChIP_MEFs_Mouse0.68936805

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.79735915
2MP0001835_abnormal_antigen_presentation3.67544580
3MP0003436_decreased_susceptibility_to3.56145108
4MP0009785_altered_susceptibility_to3.44664001
5MP0005387_immune_system_phenotype3.16303582
6MP0001790_abnormal_immune_system3.16303582
7* MP0005000_abnormal_immune_tolerance3.11362069
8MP0003724_increased_susceptibility_to3.06662484
9MP0000685_abnormal_immune_system3.01277422
10MP0004510_myositis2.90344153
11MP0002148_abnormal_hypersensitivity_rea2.88962952
12* MP0001800_abnormal_humoral_immune2.85372393
13MP0002419_abnormal_innate_immunity2.76983067
14MP0005671_abnormal_response_to2.72949054
15* MP0002452_abnormal_antigen_presenting2.71668488
16MP0005025_abnormal_response_to2.70714096
17* MP0002723_abnormal_immune_serum2.62387782
18MP0004947_skin_inflammation2.51717869
19MP0006082_CNS_inflammation2.47131632
20* MP0001819_abnormal_immune_cell2.35238260
21* MP0002420_abnormal_adaptive_immunity2.34229377
22MP0002405_respiratory_system_inflammati2.23575688
23MP0009278_abnormal_bone_marrow2.18636972
24MP0003763_abnormal_thymus_physiology2.10494598
25MP0010155_abnormal_intestine_physiology2.08983635
26MP0005451_abnormal_body_composition2.03575315
27MP0008004_abnormal_stomach_pH2.00624757
28MP0001853_heart_inflammation2.00068103
29MP0001533_abnormal_skeleton_physiology1.94964479
30MP0009333_abnormal_splenocyte_physiolog1.86682495
31MP0003300_gastrointestinal_ulcer1.85845958
32* MP0001845_abnormal_inflammatory_respons1.85002461
33* MP0002398_abnormal_bone_marrow1.82776907
34* MP0000716_abnormal_immune_system1.80109767
35MP0003448_altered_tumor_morphology1.78430947
36MP0005464_abnormal_platelet_physiology1.77442866
37MP0002139_abnormal_hepatobiliary_system1.74928531
38MP0002006_tumorigenesis1.72710524
39MP0005397_hematopoietic_system_phenotyp1.54587831
40MP0001545_abnormal_hematopoietic_system1.54587831
41MP0005076_abnormal_cell_differentiation1.53558803
42* MP0000689_abnormal_spleen_morphology1.52443708
43MP0009764_decreased_sensitivity_to1.52225286
44MP0003453_abnormal_keratinocyte_physiol1.50319925
45MP0002332_abnormal_exercise_endurance1.49260609
46MP0002933_joint_inflammation1.49100940
47MP0000858_altered_metastatic_potential1.47780566
48MP0001873_stomach_inflammation1.46954729
49MP0002166_altered_tumor_susceptibility1.46419133
50* MP0002722_abnormal_immune_system1.45103887
51* MP0002429_abnormal_blood_cell1.44989092
52MP0008469_abnormal_protein_level1.41936521
53MP0000343_altered_response_to1.41598431
54MP0002998_abnormal_bone_remodeling1.40719588
55MP0010352_gastrointestinal_tract_polyps1.38701229
56MP0002277_abnormal_respiratory_mucosa1.35817509
57MP0005310_abnormal_salivary_gland1.35618210
58MP0002254_reproductive_system_inflammat1.32466520
59MP0001851_eye_inflammation1.31878845
60MP0005167_abnormal_blood-brain_barrier1.28998388
61MP0002138_abnormal_hepatobiliary_system1.24584302
62MP0004808_abnormal_hematopoietic_stem1.21896374
63MP0000604_amyloidosis1.21703160
64MP0003656_abnormal_erythrocyte_physiolo1.17994864
65MP0003866_abnormal_defecation1.16168347
66MP0000490_abnormal_crypts_of1.14647018
67MP0000703_abnormal_thymus_morphology1.13770678
68MP0005390_skeleton_phenotype1.09184293
69MP0005058_abnormal_lysosome_morphology1.05121547
70MP0003566_abnormal_cell_adhesion1.04553962
71MP0003075_altered_response_to1.03862866
72MP0009840_abnormal_foam_cell1.00930518
73MP0003828_pulmonary_edema0.99412172
74MP0000465_gastrointestinal_hemorrhage0.95885362
75MP0010307_abnormal_tumor_latency0.95770094
76MP0001216_abnormal_epidermal_layer0.93755588
77MP0005023_abnormal_wound_healing0.93692613
78MP0003191_abnormal_cellular_cholesterol0.92267841
79MP0005166_decreased_susceptibility_to0.91321063
80MP0006054_spinal_hemorrhage0.90586304
81MP0008260_abnormal_autophagy0.90095824
82MP0003690_abnormal_glial_cell0.87490232
83MP0009765_abnormal_xenobiotic_induced0.85895100
84MP0002396_abnormal_hematopoietic_system0.84725838
85MP0002796_impaired_skin_barrier0.83144701
86MP0003091_abnormal_cell_migration0.83074395
87MP0009763_increased_sensitivity_to0.80536674
88MP0001542_abnormal_bone_strength0.78391293
89MP0004782_abnormal_surfactant_physiolog0.77713356
90MP0003806_abnormal_nucleotide_metabolis0.77629973
91MP0002060_abnormal_skin_morphology0.75253696
92MP0002877_abnormal_melanocyte_morpholog0.74467241
93MP0003195_calcinosis0.74287567
94MP0005165_increased_susceptibility_to0.73926375
95MP0001191_abnormal_skin_condition0.73354322
96MP0003183_abnormal_peptide_metabolism0.73242728
97MP0000249_abnormal_blood_vessel0.73226759
98MP0003795_abnormal_bone_structure0.72734166
99MP0001881_abnormal_mammary_gland0.71144187
100MP0005666_abnormal_adipose_tissue0.70600792
101MP0005164_abnormal_response_to0.69903837
102MP0010234_abnormal_vibrissa_follicle0.69402894
103MP0005174_abnormal_tail_pigmentation0.68537714
104MP0001501_abnormal_sleep_pattern0.68050126
105MP0002136_abnormal_kidney_physiology0.67775908
106MP0004883_abnormal_blood_vessel0.67225769
107MP0003172_abnormal_lysosome_physiology0.67127340
108MP0001663_abnormal_digestive_system0.66235911
109MP0003045_fibrosis0.65943899
110MP0002019_abnormal_tumor_incidence0.65907909
111MP0004381_abnormal_hair_follicle0.65309631
112MP0000569_abnormal_digit_pigmentation0.64198608
113MP0008874_decreased_physiological_sensi0.63575713
114MP0000627_abnormal_mammary_gland0.63286992
115MP0009931_abnormal_skin_appearance0.61945481
116MP0001243_abnormal_dermal_layer0.61595071
117MP0000609_abnormal_liver_physiology0.60730388
118MP0005257_abnormal_intraocular_pressure0.60243860
119MP0008057_abnormal_DNA_replication0.57310467
120MP0003705_abnormal_hypodermis_morpholog0.57133776
121MP0008007_abnormal_cellular_replicative0.55629417
122MP0000767_abnormal_smooth_muscle0.54059681

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.01334100
2Recurrent abscess formation (HP:0002722)5.75670661
3Stomatitis (HP:0010280)5.52936132
4Retrobulbar optic neuritis (HP:0100654)5.28653566
5Optic neuritis (HP:0100653)5.28653566
6Recurrent bacterial skin infections (HP:0005406)5.22516415
7Myositis (HP:0100614)5.16812840
8Orchitis (HP:0100796)5.15131945
9Elevated erythrocyte sedimentation rate (HP:0003565)5.05073682
10Mediastinal lymphadenopathy (HP:0100721)4.50786073
11Recurrent fungal infections (HP:0002841)4.04905416
12Abnormality of macrophages (HP:0004311)4.04854102
13Recurrent gram-negative bacterial infections (HP:0005420)3.99227864
14Vasculitis (HP:0002633)3.93135106
15Dysostosis multiplex (HP:0000943)3.65315374
16Autoimmune thrombocytopenia (HP:0001973)3.63853852
17Loss of speech (HP:0002371)3.60130137
18Obstructive lung disease (HP:0006536)3.52101898
19Chronic obstructive pulmonary disease (HP:0006510)3.52101898
20Pulmonary infiltrates (HP:0002113)3.51571217
21Pustule (HP:0200039)3.47921246
22Recurrent skin infections (HP:0001581)3.46269260
23Gingivitis (HP:0000230)3.45125792
24Keratoconjunctivitis sicca (HP:0001097)3.40247228
25Recurrent viral infections (HP:0004429)3.35415038
26Keratoconjunctivitis (HP:0001096)3.16503364
27Increased IgE level (HP:0003212)3.14413523
28Arterial thrombosis (HP:0004420)3.09514120
29Interstitial pulmonary disease (HP:0006530)3.05963152
30Meningitis (HP:0001287)3.05568153
31Cellulitis (HP:0100658)3.01679029
32IgM deficiency (HP:0002850)2.98555603
33Recurrent cutaneous fungal infections (HP:0011370)2.98067999
34Chronic mucocutaneous candidiasis (HP:0002728)2.98067999
35Leukocytosis (HP:0001974)2.97840109
36Thick nail (HP:0001805)2.97479096
37Increased IgM level (HP:0003496)2.85183506
38Gastrointestinal infarctions (HP:0005244)2.80117368
39Abnormality of mucopolysaccharide metabolism (HP:0011020)2.77444952
40Abnormality of polysaccharide metabolism (HP:0011012)2.77444952
41Abnormality of glycosaminoglycan metabolism (HP:0004371)2.77444952
42Chronic otitis media (HP:0000389)2.76029374
43Hemoptysis (HP:0002105)2.75584927
44Malnutrition (HP:0004395)2.72154964
45Disinhibition (HP:0000734)2.71474727
46Increased serum ferritin (HP:0003281)2.66140567
47Urinary glycosaminoglycan excretion (HP:0003541)2.64376765
48Mucopolysacchariduria (HP:0008155)2.64376765
49Eosinophilia (HP:0001880)2.62467783
50Nuclear cataract (HP:0100018)2.60445046
51Autoimmune hemolytic anemia (HP:0001890)2.58951085
52Urticaria (HP:0001025)2.58017359
53Myocardial infarction (HP:0001658)2.57456325
54Abnormality of T cell number (HP:0011839)2.56675684
55Systemic lupus erythematosus (HP:0002725)2.56622795
56Gastrointestinal stroma tumor (HP:0100723)2.54819087
57Amyloidosis (HP:0011034)2.53016050
58Parakeratosis (HP:0001036)2.52020854
59Periodontitis (HP:0000704)2.50013065
60Osteomyelitis (HP:0002754)2.49801835
61Abnormal delayed hypersensitivity skin test (HP:0002963)2.48834465
62Inflammation of the large intestine (HP:0002037)2.48301336
63Prostate neoplasm (HP:0100787)2.46418446
64Hypergammaglobulinemia (HP:0010702)2.44723244
65T lymphocytopenia (HP:0005403)2.43747292
66Premature loss of primary teeth (HP:0006323)2.42759137
67Recurrent bronchitis (HP:0002837)2.42142985
68Colitis (HP:0002583)2.39659806
69Emphysema (HP:0002097)2.38996047
70Abnormality of eosinophils (HP:0001879)2.38994099
71Anorexia (HP:0002039)2.38807357
72Nasal polyposis (HP:0100582)2.36399211
73Neurofibrillary tangles (HP:0002185)2.36369837
74Vacuolated lymphocytes (HP:0001922)2.36229970
75Glomerulonephritis (HP:0000099)2.35647484
76Increased density of long bones (HP:0006392)2.33857024
77Abnormality of T cells (HP:0002843)2.33141653
78Encephalitis (HP:0002383)2.32214684
79Granulocytopenia (HP:0001913)2.30308759
80Spontaneous hematomas (HP:0007420)2.29478663
81Increased cerebral lipofuscin (HP:0011813)2.28833571
82Persistence of primary teeth (HP:0006335)2.27149543
83Gastrointestinal inflammation (HP:0004386)2.25612352
84Cheilitis (HP:0100825)2.25253613
85Basal ganglia calcification (HP:0002135)2.24999996
86Gangrene (HP:0100758)2.24518985
87Recurrent pneumonia (HP:0006532)2.24027033
88Thin bony cortex (HP:0002753)2.22925697
89Hematochezia (HP:0002573)2.21934052
90Skin ulcer (HP:0200042)2.21172742
91Gingival bleeding (HP:0000225)2.20418625
92Lymphopenia (HP:0001888)2.19964696
93IgA deficiency (HP:0002720)2.19111293
94Abnormality of cells of the lymphoid lineage (HP:0012140)2.19033502
95Abnormality of T cell physiology (HP:0011840)2.17088359
96Thyroiditis (HP:0100646)2.14908458
97Abnormality of the pleura (HP:0002103)2.14337002
98Increased neuronal autofluorescent lipopigment (HP:0002074)2.13642004
99Polyneuropathy (HP:0001271)2.10887126
100Petechiae (HP:0000967)2.10879407
101Arthralgia (HP:0002829)2.09694978
102Panhypogammaglobulinemia (HP:0003139)2.09212925
103Segmental peripheral demyelination/remyelination (HP:0003481)2.08804133
104Abnormality of the nasal mucosa (HP:0000433)2.06832466
105Recurrent lower respiratory tract infections (HP:0002783)2.06271732
106Severe combined immunodeficiency (HP:0004430)2.06158247
107Agammaglobulinemia (HP:0004432)2.06090121
108Restrictive lung disease (HP:0002091)2.04123126
109Combined immunodeficiency (HP:0005387)2.03733282
110Abnormality of iron homeostasis (HP:0011031)2.01951764
111Abnormality of the pericardium (HP:0001697)2.01315498
112Neuronal loss in central nervous system (HP:0002529)2.00141402
113IgG deficiency (HP:0004315)1.99724074
114Mutism (HP:0002300)1.99342132
115Purpura (HP:0000979)1.98898187
116Chronic diarrhea (HP:0002028)1.96580334
117Chest pain (HP:0100749)1.94925867
118Apathy (HP:0000741)1.93991364
119Axonal loss (HP:0003447)1.93915935
120Glomerulopathy (HP:0100820)1.93785201
121Thrombocytosis (HP:0001894)1.93550766
122Abnormality of glycolipid metabolism (HP:0010969)1.92160936
123Abnormality of liposaccharide metabolism (HP:0010968)1.92160936
124Abnormality of glycosphingolipid metabolism (HP:0004343)1.92160936
125Episodic fever (HP:0001954)1.91900910
126Peritonitis (HP:0002586)1.91832355
127Joint swelling (HP:0001386)1.90993454
128Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.89959819
129Diminished motivation (HP:0000745)1.87893757
130Hepatosplenomegaly (HP:0001433)1.86774265
131Asymmetric septal hypertrophy (HP:0001670)1.86390704
132Progressive neurologic deterioration (HP:0002344)1.86252697
133Acne (HP:0001061)1.83684380
134Pulmonary embolism (HP:0002204)1.82889412
135Keratitis (HP:0000491)1.79005045

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.73906705
2MAP3K144.70936291
3MAP4K13.86852755
4TXK3.53558737
5TBK13.18067781
6PRPF4B2.81259467
7TYK22.79508973
8IRAK42.65765245
9IKBKE2.62681238
10RIPK42.38945618
11* IKBKB2.36733513
12JAK32.35721286
13BLK2.17193686
14JAK12.06462791
15CHUK2.03078230
16GRK72.01596439
17DDR21.98761927
18EPHB11.87235565
19STK101.76881008
20ERN11.71985050
21MST41.71275098
22ZAP701.70324900
23PIM21.64842791
24MAP3K101.57962825
25CSK1.57825201
26PIM11.49435448
27TAOK31.48541110
28RPS6KA41.45066233
29HCK1.43259155
30KIT1.42165454
31CDC42BPA1.40176615
32BTK1.39570247
33IRAK21.37312124
34SIK11.33162820
35MOS1.31227991
36TEC1.29559148
37EPHA31.28473982
38TRIB31.27136367
39SYK1.22018065
40FGFR41.16988653
41ITK1.16492153
42MAP3K131.16079560
43LCK1.15768821
44CLK11.10556600
45TGFBR21.09677371
46PBK1.09081613
47CDK121.08778426
48BMX1.07509453
49GRK61.06267216
50MARK31.05896807
51NLK1.01180724
52FGFR30.98520399
53SIK30.94964955
54LYN0.94244302
55NME20.93627759
56CSF1R0.93171356
57JAK20.90420391
58MAP3K30.81616452
59IRAK10.80276834
60EPHA20.79884962
61MAP2K30.79805517
62EIF2AK20.77451990
63ICK0.76416381
64FES0.75756434
65BMPR20.74075558
66MAP3K110.73694748
67TESK20.72567812
68LRRK20.72099688
69SIK20.70784079
70LATS20.70052605
71TRPM70.67831523
72FGR0.66199575
73STK40.64511738
74ABL10.64264175
75SMG10.63562598
76STK240.61241776
77MAPK70.60563260
78RPS6KA50.59328210
79ABL20.55885138
80PTK60.55690483
81MATK0.54991777
82TAOK20.54799241
83PDGFRA0.54619704
84STK30.54575045
85TYRO30.53377675
86MAPKAPK20.53230470
87ALK0.52863094
88ARAF0.52369425
89NEK90.52250531
90MST1R0.51134203
91MARK20.49309046
92RIPK10.48987935
93PDPK10.48386397
94PDK10.46951521
95TNK20.46144664
96RPS6KA10.44649629
97EGFR0.43940458
98RPS6KA60.42771971
99ADRBK20.41970312
100YES10.41664847
101MAP2K60.41329703
102CDK60.41163633
103MAP3K50.39955332
104PRKD20.39666984
105PRKCD0.37707686
106MAPK150.36444210
107GSK3A0.35789250
108KSR20.33828272
109CDK40.33287384
110MAPK110.32847030
111PRKG20.32700203
112PAK40.32169149
113PRKCQ0.31907654
114RPS6KA20.31878865
115TSSK60.31576889
116TTN0.31173389
117MAP3K10.30568312
118MELK0.30048957
119ACVR1B0.28425034
120TAOK10.27161458
121RPS6KC10.26726527
122RPS6KL10.26726527
123INSR0.26252284
124PDGFRB0.25733302
125HIPK20.25291240
126MAPK40.24959286
127MAP3K80.23913233
128CDK90.23183224

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.21830151
2NF-kappa B signaling pathway_Homo sapiens_hsa040643.16577419
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.77795377
4Graft-versus-host disease_Homo sapiens_hsa053322.77002828
5Osteoclast differentiation_Homo sapiens_hsa043802.63890871
6NOD-like receptor signaling pathway_Homo sapiens_hsa046212.53050259
7Allograft rejection_Homo sapiens_hsa053302.41982549
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.29705834
9Legionellosis_Homo sapiens_hsa051342.27327787
10Measles_Homo sapiens_hsa051622.25994911
11TNF signaling pathway_Homo sapiens_hsa046682.18923206
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.17253913
13Malaria_Homo sapiens_hsa051442.17102042
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.10586672
15Intestinal immune network for IgA production_Homo sapiens_hsa046722.07612467
16Primary immunodeficiency_Homo sapiens_hsa053402.04945954
17Staphylococcus aureus infection_Homo sapiens_hsa051502.00127109
18Asthma_Homo sapiens_hsa053101.97115477
19B cell receptor signaling pathway_Homo sapiens_hsa046621.94768582
20Hematopoietic cell lineage_Homo sapiens_hsa046401.90393671
21Pertussis_Homo sapiens_hsa051331.87802109
22Toxoplasmosis_Homo sapiens_hsa051451.79269502
23Tuberculosis_Homo sapiens_hsa051521.78074401
24Influenza A_Homo sapiens_hsa051641.76774369
25Herpes simplex infection_Homo sapiens_hsa051681.70599399
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.66776255
27Rheumatoid arthritis_Homo sapiens_hsa053231.66558962
28T cell receptor signaling pathway_Homo sapiens_hsa046601.61237607
29Antigen processing and presentation_Homo sapiens_hsa046121.56924626
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.49893244
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.49395188
32Apoptosis_Homo sapiens_hsa042101.47034092
33African trypanosomiasis_Homo sapiens_hsa051431.44870901
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.44528279
35Type I diabetes mellitus_Homo sapiens_hsa049401.40393760
36Salmonella infection_Homo sapiens_hsa051321.39750233
37Shigellosis_Homo sapiens_hsa051311.32479925
38Hepatitis B_Homo sapiens_hsa051611.26766085
39Chemokine signaling pathway_Homo sapiens_hsa040621.25880125
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.22004913
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19522930
42Acute myeloid leukemia_Homo sapiens_hsa052211.18027985
43Autoimmune thyroid disease_Homo sapiens_hsa053201.15889487
44Bladder cancer_Homo sapiens_hsa052191.14042144
45Hepatitis C_Homo sapiens_hsa051601.13146786
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07370217
47Epstein-Barr virus infection_Homo sapiens_hsa051691.05696502
48Leukocyte transendothelial migration_Homo sapiens_hsa046701.03676758
49Viral myocarditis_Homo sapiens_hsa054160.96672000
50Chronic myeloid leukemia_Homo sapiens_hsa052200.94078832
51Small cell lung cancer_Homo sapiens_hsa052220.92809855
52Other glycan degradation_Homo sapiens_hsa005110.88233501
53Lysosome_Homo sapiens_hsa041420.85654909
54Amoebiasis_Homo sapiens_hsa051460.84680332
55Prolactin signaling pathway_Homo sapiens_hsa049170.83303492
56Phagosome_Homo sapiens_hsa041450.81460466
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80691473
58Pancreatic cancer_Homo sapiens_hsa052120.74105098
59HTLV-I infection_Homo sapiens_hsa051660.73128156
60Adipocytokine signaling pathway_Homo sapiens_hsa049200.72315706
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70517228
62Viral carcinogenesis_Homo sapiens_hsa052030.69085962
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67572209
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.65697682
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.64590847
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62480598
67p53 signaling pathway_Homo sapiens_hsa041150.61944509
68Platelet activation_Homo sapiens_hsa046110.56917606
69Systemic lupus erythematosus_Homo sapiens_hsa053220.56889951
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56575269
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55589438
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54596781
73Complement and coagulation cascades_Homo sapiens_hsa046100.52919747
74MicroRNAs in cancer_Homo sapiens_hsa052060.50230112
75HIF-1 signaling pathway_Homo sapiens_hsa040660.49784053
76Notch signaling pathway_Homo sapiens_hsa043300.48053014
77VEGF signaling pathway_Homo sapiens_hsa043700.45102184
78FoxO signaling pathway_Homo sapiens_hsa040680.42931002
79MAPK signaling pathway_Homo sapiens_hsa040100.39015577
80Fructose and mannose metabolism_Homo sapiens_hsa000510.37181207
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.34559855
82Mineral absorption_Homo sapiens_hsa049780.34520710
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34251685
84Proteoglycans in cancer_Homo sapiens_hsa052050.34093493
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32913581
86Insulin resistance_Homo sapiens_hsa049310.31977640
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31492364
88mTOR signaling pathway_Homo sapiens_hsa041500.31489337
89GnRH signaling pathway_Homo sapiens_hsa049120.31234529
90Galactose metabolism_Homo sapiens_hsa000520.30116924
91Prostate cancer_Homo sapiens_hsa052150.29074377
92Type II diabetes mellitus_Homo sapiens_hsa049300.28641544
93Prion diseases_Homo sapiens_hsa050200.28264444
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.27873100
95Endocytosis_Homo sapiens_hsa041440.27009620
96Sphingolipid metabolism_Homo sapiens_hsa006000.25918021
97ErbB signaling pathway_Homo sapiens_hsa040120.25810063
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.25746763
99Pathways in cancer_Homo sapiens_hsa052000.24743079
100Adherens junction_Homo sapiens_hsa045200.24391082
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.24152521
102Colorectal cancer_Homo sapiens_hsa052100.23368227
103Renal cell carcinoma_Homo sapiens_hsa052110.23261098
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.22001536
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21384466
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20128669
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.17954060
108Caffeine metabolism_Homo sapiens_hsa002320.17784121
109Dorso-ventral axis formation_Homo sapiens_hsa043200.17225763
110Renin-angiotensin system_Homo sapiens_hsa046140.14182078
111Arachidonic acid metabolism_Homo sapiens_hsa005900.13849154
112Non-small cell lung cancer_Homo sapiens_hsa052230.13767246

Most similar genes based on co-expression Upload to Enrichr

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